en en en fi en en fi en en zh fi fi en fi en en en id en fi en it en en zh en en de eo en en fi jbo en en es ru fr en es en en en en en da en uk en en en sv en en pl en uk it war en es war fi jbo fi fi jbo fi en es es fi jbo es en es fi fi jbo fi en es fi fi jbo fi en es en fi jbo en en es fi fr en fi en fi en en en en en fi jbo en en es en en en it en pt id de en en sl en en en en es fi en fi en en fi en en fi en en fi en en en en en en en en en en en en en en en fa en en en en fi en en en en en en en en en en en en en en
JYX - Validation of the breast cancer Analysis Protocol Packages (APPs) for the determination of estrogen and progesterone receptors (ER, PR), human epidermal growth factor recep- tor 2 (HER2) and proliferation index (Ki67) in breast cancer (full record)
University of Jyväskylä | JYX Digital Repository
English  | Give feedback |
JavaScript is disabled for your browser. Some features of this site may not work without it.
Breast cancer is the most common cancer among women worldwide. It has a signif- icant effect on the public health and thus it is widely studied and many prognostic and predictive factors have been identified. They are used to optimize the treatment for the patient. Aim of this Thesis work was to validate analysis protocol packages (APPs) in commercial digital image analysis software VIS by Visiopharm. Validation was done for the determination of prognostic factors for clinical use in the pathol- ogy department of Seinäjoki Central Hospital. The validation was done to estrogen receptor (ER APP), progesterone receptor (PR APP), proliferation index Ki67 (Ki67 APP) and human epidermal growth factor receptor 2 (HER2 APP) from 67 clinical cases by comparing the results the software analysis gave to the ones the pathologists had given. In ER 20, in PR 28 and in Ki67 only 14 cases were determined to have a result that differs maximum of +/- 2 % from the result given by pathologist. In HER2 the software analysis did not recognize statuses 0 and 2 as often as 1 and 3. The validation shows that the software cannot be taken into use for clinical diagnostics. However, the software can be used as a supportive tool in clinical diagnostics, if it is seen beneficial considering its time consumption, which was over 40 minutes in over half of the cases.
Validation of the breast cancer Analysis Protocol Packages (APPs) for the determination of estrogen and progesterone receptors (ER, PR), human epidermal growth factor recep- tor 2 (HER2) and proliferation index (Ki67) in breast cancer
Bio- ja ympäristötieteiden laitos
Department of Biological and Environmental Science
Cell and molecular biology
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
Tekijä ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyväskylän yliopiston kirjaston arkistotyösemalta. Ks. https://kirjasto.jyu.fi/kokoelmat/arkistotyoasema..
The author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyväskylä University Library (https://kirjasto.jyu.fi/collections/archival-workstation).
Files in this item
This item appears in the following Collection(s)
Pro gradu -tutkielmat [24101]
Show simple item record
Showing items with similar title or keywords.
Transformers for breast cancer classification
Rintasyöpä on maailmanlaajuisesti naisten yleisin syöpä, sen varhainen havaitseminen voi merkittävästi vähentää siihen liittyvää kuolleisuutta. Histopatologista analyysiä tarvitaan kasvainten laadun määrittämiseksi ...
Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women : Results from the prospective controlled BREX exercise study
Roine, Eija; Sintonen, Harri; Kellokumpu-Lehtinen, Pirkko-Liisa; Penttinen, Heidi; Utriainen, Meri; Vehmanen, Leena; Huovinen, Riikka; Kautiainen, Hannu; Nikander, Riku; Blomqvist, Carl; Hakamies-Blomqvist, Liisa; Saarto, Tiina (Elsevier, 2021)
Objective  To investigate long-term health-related quality of life (HRQoL) changes over time in younger compared to older disease-free breast cancer survivors who participated in a prospective randomized exercise ...
Neuromuscular, hormonal and molecular responses to heavy resistance training in strength trained men : with special reference to various resistance exercise protocols, serum hormones and gene expression of androgen receptor and insulin-like growth factor-I
Ahtiainen, Juha (University of Jyväskylä, 2006)
The present study was designed to obtain more information on mechanisms leading to muscle hypertrophy by determination of the effects of different heavy resistance exercise protocols on acute and chronic neuromuscular and ...
Does breast carcinoma belong to the Lynch syndrome tumor spectrum? : Somatic mutational profiles vs. ovarian and colorectal carcinomas
Porkka, Noora K.; Olkinuora, Alisa; Kuopio, Teijo; Ahtiainen, Maarit; Eldfors, Samuli; Almusa, Henrikki; Mecklin, Jukka-Pekka; Peltomäki, Päivi (Impact Journals LLC, 2020)
Inherited DNA mismatch repair (MMR) defects cause predisposition to colorectal, endometrial, ovarian, and other cancers occurring in Lynch syndrome (LS). It is unsettled whether breast carcinoma belongs to the LS tumor ...
Tissue microarray technology in breast cancer subtyping
Tunes and musical notes
All of JYXCollection listBy Issue DateAuthorsSubjectsPublished inDepartmentDiscipline
How to publish in JYX?
Publish Your Thesis Online
Open Science at the JYU
Unless otherwise specified, publicly available JYX metadata (excluding abstracts) may be freely reused under the CC0 waiver.