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Comparative Metabolomics Analysis of Juvenile Takifugu obscurus serum and Liver Samples after Exposure to Tributyltin Chloride
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Comparative Metabolomics Analysis of Juvenile Takifugu obscurus serum and Liver Samples after Exposure to Tributyltin Chloride
Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, Jiangsu 214081, China
Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, Jiangsu 214081, China
Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, 214081, Wuxi, China
Final revision date: 2020-11-17
Online publication date: 2021-05-21
Pol. J. Environ. Stud. 2021;30(4):3849–3875
Tributyltin chloride (TBT-Cl), one of the most representative chemical compounds of tributyltin (TBT), is a threat to aquatic organisms due to evidence of fatal toxicity, which has attracted much interest in the scientific community. We studied the effects of acute TBT-Cl exposure on the juvenile Takifugu obscurus metabolism by investigating the metabolite contents in the serum and liver at three TBT-Cl concentrations and in a control group using the LC-MS technology. The metabolites that showed different levels in the serum and liver under different TBT-C1 concentrations were primarily related to sphingolipid metabolism, phosphoglyceride metabolism, and the biosynthesis of unsaturated fatty acids. Moreover, we found that TBT-Cl exposure increased the concentration of lysophosphatidylcholine and prostaglandin E2, resulting in higher detoxification capacity and inhibiting inflammation. These results may explain the higher tolerance of juvenile T. obscurus to TBT-Cl compared with other fish species. Overall, the present study contributes new information of the influences of TBT-Cl on juvenile T. obscurus metabolism.
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