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Treatment of non-Hodkin´s lynphoma associated with acquired inmunodeficiency syndrome (AIDS) at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Gac Med Mex 2006; 142 (2)
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AIDS, non-Hodgkin’s lymphoma, antiretroviral treatment, EPOCH.
Background: Survival in patients with acquired immunodeficiency syndrome (AIDS) related non-Hodgkin’s Lymphoma has improved with the use of High Active Antiretroviral Therapy (HAART) and less toxic chemotherapy.
Material and methods: Clinical characteristics and outcome among patients treated for AIDS related non-Hodgkin’s Lymphoma are described. Nine patients were studied retrospectively. Overall survival (OS) and Free Disease Survival (FDS) using a Kaplan-Meier model were analyzed.
Results: Patients received (DA-EPOCH) etoposide, prednisone, vincristine, doxorubicin and cyclophosphamide. The overall Survival was 18 months and 13 month Free Disease Survival with a median follow-up of 16 months showing full response in 8/9 patients was observed.
Conclusions: A very satisfactory treatment response in this group of patients expressed as an increased Overall Survival was noted.
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