SARS-CoV-2
{{Infobox spesies
| image             = Novel Coronavirus SARS-CoV-2.jpg
| image_alt         = 
| image_caption     = Gambaran mikroskop transmisi elektron yang menunjukkan virion SARS-CoV-2
| image2            = 2019-nCoV-CDC-23312.png
| image2_alt        = Ilustrasi koronavirus nang diulah ulih [[Pusat Pengendalian dan Pencegahan Penyakit]] (CDC).
| image2_caption    = Ilustrasi koronavirus nang diulah ulih [[Pusat Pengendalian dan Pencegahan Penyakit]] (CDC).
| parent            = 
| virus             = SARS-CoV-2
| synonyms          = 
* Koronavirus Wuhan
* Virus pneumonia pasar makanan laut Wuhan
| synonyms_ref      = 
| range_map         = {{Location map|China|float=center|caption=|lat_deg=30|lat_min=37|lat_sec=11|lat_dir=N|lon_deg=114|lon_min=15|lon_sec=26|lon_dir=E}}
| range_map_caption = Wuhan, Tiongkok, lukasi tajadinya wabah virus
| Death Toll        = 
* 1.018 per 10 Februari 2020 UTC+08.00
}}

'''Koronavirus sindrom pahinakan akut barat 2''' atawa '''SARS-CoV-2'''<ref name="Gorbalenya">{{Cite journal|last=Gorbalenya|first=Alexander E.|date=11 Februari 2020|title=Severe acute respiratory syndrome-related coronavirus – The species and its viruses, a statement of the Coronavirus Study Group|url=https://www.biorxiv.org/content/10.1101/2020.02.07.937862v1|journal=bioRxiv|language=en|pages=2020.02.07.937862}}</ref><ref name="ictv">{{Cite web|url=https://talk.ictvonline.org/|title=ICTV|access-date=12 Februari 2020|archive-date=2022-08-04|archive-url=https://web.archive.org/web/20220804195334/https://talk.ictvonline.org/|dead-url=yes}}</ref> ({{lang-en|Severe acute respiratory syndrome coronavirus 2}}) adalah sabuting angguta [[koronavirus]] nang maulah jangkitan pahinakan [[COVID-19]]. Virus ngini panambaian diidintipikasi di Kuta [[Wuhan]], [[Ripublik Rakyat Cina|Tiongkok]] wan maulah [[pandemi COVID-19]]. Virus naya jua dipinandui sebagai '''koronavirus Wuhan''' dan '''virus pneumonia pasar makanan laut Wuhan''' (''Wuhan seafood market pneumonia virus'').<ref name="MN908947">{{cite journal |last1=Zhang |first1=Y.-Z. |display-authors=etal |title=Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome |url=https://www.ncbi.nlm.nih.gov/nuccore/MN908947 |website=GenBank |accessdate=13 Januari 2020 |location=Bethesda MD |date=12 Januari 2020}}</ref>

[[Genom]] virus naya sudah diurutkan.<ref>{{cite web|url=http://www.chinacdc.cn/dfdt/201912/t20191226_209404.html|title=中国疾病预防控制中心|website=chinacdc.cn|access-date=9 Januari 2020|archive-date=2020-02-06|archive-url=https://web.archive.org/web/20200206072618/http://www.chinacdc.cn/dfdt/201912/t20191226_209404.html|dead-url=yes}}</ref><ref name=":0">{{cite web|url=http://www.xinhuanet.com/english/2020-01/09/c_138690570.htm|title=New-type coronavirus causes pneumonia in Wuhan: expert|agency=Xinhua|access-date=9 Januari 2020|archive-date=2020-01-09|archive-url=https://web.archive.org/web/20200109084208/http://www.xinhuanet.com/english/2020-01/09/c_138690570.htm|dead-url=yes}}</ref><ref name=":1">{{cite web|url=https://platform.gisaid.org/epi3/start/CoV2020|title=CoV2020|website=platform.gisaid.org|url-status=live|access-date=12 Januari 2020}}</ref> Pabandingan urutan genetik antara virus naya wan sampel virus lain manunjukkan tingkat kasamaan lawan [[SARS-CoV]] saganal 79,5% wan lawan koronavirus kalalawar saganal 96%.<ref name="sarscov">http://www.biorxiv.org/content/10.1101/2020.01.22.914952v1.full.pdf</ref> Beberapa teori menyimpulkan bahwa virus naya berasal dari kalalawar.<ref name=nexstrain>Sampel [https://www.ncbi.nlm.nih.gov/nuccore/MG772933 CoVZC45] and [https://www.ncbi.nlm.nih.gov/nuccore/MG772934 CoVZXC21], lihat [https://nextstrain.org/groups/blab/sars-like-cov visualisasi interaktif]</ref><ref name=evoevidence>{{cite journal|title=The 2019 new Coronavirus epidemic: evidence for virus evolution|url=https://www.biorxiv.org/content/10.1101/2020.01.24.915157v1}}</ref><ref>{{Cite journal|last=Callaway|first=Ewen|last2=Cyranoski|first2=David|date=2020-01-23|title=Why snakes probably aren’t spreading the new China virus|url=https://www.nature.com/articles/d41586-020-00180-8|journal=Nature|language=en}}</ref>

== Pangaranan ==
Salawas wabah nang haratan balangsung, virus ngni rancak disambat sacara umum sabagai "koronavirus", "koronavirus hanyar" wan "koronavirus Wuhan",<ref name=BBCname>{{cite news|url=https://www.bbc.com/news/world-asia-china-51371770|title=How the new coronavirus will finally get a proper name|last1=Taylor-Coleman|first1=Jasmine|publisher=BBC|date=5 Februari 2020|accessdate=12 Februari 2020|archive-url=https://web.archive.org/web/20200205190745/https://www.bbc.com/news/world-asia-china-51371770|archive-date=5 Februari 2020|language=en|url-status=live}}</ref><ref name=Fortune>{{Cite web |url=https://fortune.com/2020/02/08/wuhan-coronavirus-disease-names/ |title=Wuhan coronavirus? 2019 nCoV? Naming a new disease |last=Stobbe |first=Mike|date=8 Februari 2020|website=Fortune|language=en-US |access-date=12 Februari 2020|url-status=live }}</ref> amum WHO manyaranakan ngaran pahadangannya "2019-nCoV" di tangah katakutanan bahwa  kadada  ngaran rasmi nang kawa maulah pamakaian ngaran-ngaran infurmal nang marugiakan, per padjman WHO tahun 2015,<ref name=Fortune/><ref>[https://apps.who.int/iris/bitstream/handle/10665/163636/WHO_HSE_FOS_15.1_eng.pdf World Health Organization Best Practices for the Naming of New Human Infectious Diseases]. Organisasi Kesehatan Dunia. Mei 2015.</ref>

Kalumpok Studi Koronavirus matan [[Komite Internasional Taksonomi Virus]] (ICTV) mambari'i virus naya ngaran ''koronavirus sindrom pahinakan akut barat 2'' (SARS-CoV-2) nang marupakan galur dalam spesies [[SARS-CoV]].<ref name="ictv/> Panyakit nang disababakan ulih virus ngini dibari ngaran "penyakit koronavirus 2019" (COVID-19) ulih WHO.<ref>{{Cite web|url=https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020|title=WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020|website=www.who.int|agency=Organisasi Kesehatan Dunia|language=en|access-date=11 Februari 2020}}</ref>

=== Struktur biologi ===
[[Berkas:Coronavirus 2019-nCoV.3.png|jmpl|ka|Diagram pita Innophore [[Phyre|Phyre2]] matan [[Protease]] SARS-CoV-2, target prospektif gasan [[obat antivirus]].<ref name=inno-dock />]]
Publikasi genom mambari jalan gasan sapalihan [[Prediksi struktur protein|pemodelan protein]] gasan protein pangikat [[reseptor (biokimia)|reseptor]] (RBD), yaitu protein ''spike'' (S). Protein S dipinandui mampartahanakan afinitas nang cukup tahadap reseptor [[enzim pengubah angiotensin]] 2 (ACE2) wan mamakainya gasan masuk ka dalam sel.<ref>{{cite journal |title=Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission |url= http://engine.scichina.com/publisher/scp/journal/SCLS/doi/10.1007/s11427-020-1637-5 |journal=SCIENCE CHINA Life Sciences |accessdate=23 Januari 2020}}</ref> Pas 22 Januari, dua kalumpuk nang balaim (sabuting di Tiongkok nang bagawi lawan virus langkap wan sabuting di AS nang bagawi lawan genetik balik) sacara independen manampaiakan paranan ACE2 gasan reseptor di SARS-CoV-2.<ref>{{cite journal |last1=Letko |first1=Michael |last2=Munster |first2=Vincent |date=22 Januari 2020 |title=Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV |url= https://www.biorxiv.org/content/10.1101/2020.01.22.915660v1 |journal=BiorXiv |accessdate=28 Januari 2020}}</ref><ref>{{cite journal |last1=Zhou |first1=Peng |last2=Shi |first2=Zheng-Li |date=2020 |title=Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin |url=https://www.biorxiv.org/content/10.1101/2020.01.22.914952v2 |journal=BiorXiv |doi=10.1101/2020.01.22.914952 |accessdate=24 Januari 2020}}</ref><ref>{{cite journal |last1=Gralinski |first1=Lisa E. |last2=Menachery |first2=Vineet D. |date=2020 |title=Return of the Coronavirus: 2019-nCoV |journal=Viruses |volume=12 |issue=2 |pages=135}}</ref>

Gasan mencari protease inhibitor nang potensial, enzim [[endopeptidase C30]] mata poliprotein [[rangka baca terbuka]] 1a (Orf1a) dimodelkan jua gasan parcobaan [[docking (molekuler)|docking]] obat. Innophore sudaj mahasilkan dua model komputasi badasarkan protease SARS,<ref name=inno-dock>{{cite web |url=https://innophore.com/2019-ncov/ |title=Wuhan coronavirus 2019-nCoV - what we can find out on a structural bioinformatics level |last1=Gruber |first1=Christian |last2=Steinkellner |first2=Georg |date=23 Januari 2020 |website=Innophore Enzyme Discovery |publisher=Innophore GmbH}}</ref> wan Akademi Ilmu Pengetahuan Tiongkok sudah mahasilakan struktur eksperimental rekombinan protease SARS-CoV-2 nang balum dipublikasiakan <ref name=cas-dock>{{cite web |title=上海药物所和上海科技大学联合发现一批可能对新型肺炎有治疗作用的老药和中药 |url=http://www.cas.cn/syky/202001/t20200125_4732909.shtml |website=Akademi Ilmu Pengetahuan Tiongkok |date=25 Januari 2020}}</ref>

== Catatan Batis ==
<references/>

{{Stub}}

[[Tumbung:WikiBaiman]]
[[Tumbung:Virus]]
Koronavirus sindrom pahinakan akut barat 2 atawa SARS-CoV-2 () adalah sabuting angguta koronavirus nang maulah jangkitan pahinakan COVID-19. Virus ngini panambaian diidintipikasi di Kuta Wuhan, Tiongkok wan maulah pandemi COVID-19. Virus naya jua dipinandui sebagai koronavirus Wuhan dan virus pneumonia pasar makanan laut Wuhan (Wuhan seafood market pneumonia virus).

Genom virus naya sudah diurutkan. Pabandingan urutan genetik antara virus naya wan sampel virus lain manunjukkan tingkat kasamaan lawan SARS-CoV saganal 79,5% wan lawan koronavirus kalalawar saganal 96%.http://www.biorxiv.org/content/10.1101/2020.01.22.914952v1.full.pdf Beberapa teori menyimpulkan bahwa virus naya berasal dari kalalawar.Sampel CoVZC45 and CoVZXC21, lihat visualisasi interaktif

 Pangaranan 
Salawas wabah nang haratan balangsung, virus ngni rancak disambat sacara umum sabagai "koronavirus", "koronavirus hanyar" wan "koronavirus Wuhan", amum WHO manyaranakan ngaran pahadangannya "2019-nCoV" di tangah katakutanan bahwa  kadada  ngaran rasmi nang kawa maulah pamakaian ngaran-ngaran infurmal nang marugiakan, per padjman WHO tahun 2015,World Health Organization Best Practices for the Naming of New Human Infectious Diseases. Organisasi Kesehatan Dunia. Mei 2015.

Kalumpok Studi Koronavirus matan Komite Internasional Taksonomi Virus (ICTV) mambari'i virus naya ngaran koronavirus sindrom pahinakan akut barat 2 (SARS-CoV-2) nang marupakan galur dalam spesies SARS-CoV. Panyakit nang disababakan ulih virus ngini dibari ngaran "penyakit koronavirus 2019" (COVID-19) ulih WHO.

 Struktur biologi 
jmpl|ka|Diagram pita Innophore Phyre2 matan Protease SARS-CoV-2, target prospektif gasan obat antivirus.
Publikasi genom mambari jalan gasan sapalihan pemodelan protein gasan protein pangikat reseptor (RBD), yaitu protein spike (S). Protein S dipinandui mampartahanakan afinitas nang cukup tahadap reseptor enzim pengubah angiotensin 2 (ACE2) wan mamakainya gasan masuk ka dalam sel. Pas 22 Januari, dua kalumpuk nang balaim (sabuting di Tiongkok nang bagawi lawan virus langkap wan sabuting di AS nang bagawi lawan genetik balik) sacara independen manampaiakan paranan ACE2 gasan reseptor di SARS-CoV-2.

Gasan mencari protease inhibitor nang potensial, enzim endopeptidase C30 mata poliprotein rangka baca terbuka 1a (Orf1a) dimodelkan jua gasan parcobaan docking obat. Innophore sudaj mahasilkan dua model komputasi badasarkan protease SARS, wan Akademi Ilmu Pengetahuan Tiongkok sudah mahasilakan struktur eksperimental rekombinan protease SARS-CoV-2 nang balum dipublikasiakan 

 Catatan Batis 

Tumbung:WikiBaiman
Tumbung:Virus