Density
Density
[Cueball is in a bed with Megan.] Cueball: Sup dawg, I herd you didn't liek forming babby, but I accidentally in your base. [Below the frame:] Cons: Ruined life. Pros: Sentence set the new meme density record.

This comic depicts a sex scene with Cueball in bed together with Megan , and a sentence being spoken by Cueball.  The sentence's overt meaning suggests Megan doesn't wish to become pregnant, but Cueball has prematurely or unintentionally ejaculated inside her.  The sentence contains five popular (at the time) memes :
In plain English, the sentence roughly means:
Hey girl, I heard that you don't want to have a baby but I accidentally came inside you.
The comic then goes to describe the pros and cons of the situation.  "Ruined life" is listed as a major downside, as he may have caused a girl to become pregnant against her wishes, and may have to father a child with her.  The usage of memes in response to the situation also conveys an uncaring attitude that is likely to put a damper on their relationship even if she did not get pregnant.  On the other hand, it is noted that the sentence could set a new record for the density of memes (most memes packed into the fewest number of words) which can be considered a positive.  This explains the title of the comic, though it will be a very superficial and meaningless record, especially when weighed against the downsides.
The reason Cueball chose to construct the sentence with so many memes is not clear.  Since the comic lists "ruined life" as one of the cons of this scene, it would seem that the accident, as well as the subsequent use of memes, were not planned.  It's possible that Cueball had too many memes in his head and couldn't think of anything else to say amid the nervous tension.  If this were another character, say Black Hat, then it would be easier to believe that the entire night could have been staged just to give him an opportunity to use the sentence and set a record.
The title text references 4chan , a site known for its memes, trolls and other assorted Internet clutter, and sarcastically implies that any advice they might give would in any way be at all helpful. Due to its population of trolls and other unhelpful sorts, advice given by 4chan would normally be useless at best and actively detrimental at worst; however, the title text implies that Cueball regrets that he did not ask 4chan for advice, and maybe have used them for this earlier.
[Cueball is in a bed with Megan.] Cueball: Sup dawg, I herd you didn't liek forming babby, but I accidentally in your base. [Below the frame:] Cons: Ruined life. Pros: Sentence set the new meme density record.
