Scenario 4
Scenario 4
[Megan and Cueball are standing in front of a large graph, with "Time" along the horizontal axis and "Bad Stuff" along the vertical axis. The curve on the graph shows a generally shallow upward slope.] Megan: Our new models outline a few possible scenarios. Cueball: #1 is the best scenario.
[The graph now shows a much steeper curve, before flattening out far in the future, similar to a logistic curve.] Megan: Scenario 2 is not so great.
[The graph now climbs quite quickly, approximating an exponential curve.] Cueball: Scenario 3 would be pretty bad.
[The graph starts curling up, like the exponential curve, but continues curving back, so that it no longer qualifies as a function, and may indicate time-travel to the past.] Megan: Then there is scenario 4. Megan: We think it's a graphing error. Cueball: If not, we definitely want to avoid it.

Although not directly mentioned, this comic is probably the 14th comic in a row (not counting the April Fools' comic ) in a series of comics related to the COVID-19 pandemic .
In 2278: Scientific Briefing , Megan and Cueball were briefing White Hat on things that were getting bad, hoping to convince him to do something about them.  He chose to wait until things actually got bad.  Evidently, that has happened, and now Megan and Cueball are delivering another briefing on just how much "Bad Stuff" there might be, according to their models.
In the context of the information (and misinformation) explosion associated with the COVID-19 pandemic (ongoing at the time that this comic was published), many graphs have been shown highlighting the prevalence of the disease - the number of cases at any one time and place, and the change in the number of cases over time. That being said, the graphs shown could easily apply to any number of scenarios where an upward trend is bad.
Several of these graphs have attempted to predict the future, using statistical tools ("models") to process existing data and generate a forecast. Inputs to the model(s) may include different assessments of, for example, the number of COVID-19 cases that have been recorded. Four scenarios are presented here, presumably showing what a particular model (probably only one despite the reference to "new modelS" in the comic) forecasts given different, unspecified, inputs.
Megan and Cueball present four scenarios, only three of which are possible.
[Megan and Cueball are standing in front of a large graph, with "Time" along the horizontal axis and "Bad Stuff" along the vertical axis. The curve on the graph shows a generally shallow upward slope.] Megan: Our new models outline a few possible scenarios. Cueball: #1 is the best scenario.
[The graph now shows a much steeper curve, before flattening out far in the future, similar to a logistic curve.] Megan: Scenario 2 is not so great.
[The graph now climbs quite quickly, approximating an exponential curve.] Cueball: Scenario 3 would be pretty bad.
[The graph starts curling up, like the exponential curve, but continues curving back, so that it no longer qualifies as a function, and may indicate time-travel to the past.] Megan: Then there is scenario 4. Megan: We think it's a graphing error. Cueball: If not, we definitely want to avoid it.
