title: Contraindications - Neonatal Intensive Care Drug Manual
text: Potassium sparing diuretics, including spironolactone: Increase serum potassium.
  Amphotericin B Liposomal: – Can cause hypokalaemia.(4)
  Doxapram: Can cause hypokalaemia.(5)
  ACE inhibitors, including enalapril and captopril: Elevate serum potassium.
  Beta adrenergic blockers: - Increase both peak serum potassium and the time required for serum potassium to return to basal levels.
  Nonsteroidal anti-inflammatory drugs (NSAIDs): May cause hyperkalaemia by inducing secondary hypoaldosteronism.
  Heparin: Reduces the synthesis of aldosterone which may result in hyperkalaemia.
  Digitalis glycosides: Potassium supplements are not recommended for concurrent use in digitalised patients with severe or complete heart block. In treating hyperkalaemia in digitalised patients, too rapid a lowering of the serum potassium concentration can produce digitalis toxicity.(3)
  Sodium bicarbonate: Concurrent use may decrease serum potassium.
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