title: Drug Interactions - Neonatal Intensive Care Drug Manual
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  Neonatal Intensive Care Drug Manual
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  bet | 529/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Drug Interactions
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  Amiodarone — concurrent use of amiodarone and ranitidine may result in increased amiodarone exposure.
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  Adverse Reactions
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  Exposure to H2 receptor antagonists may be associated with increased risk of NEC in preterm infants.8,10,18 The use of ranitidine in infants admitted to the NICU increases the risk of late-onset sepsis.9,13,19 Use of H2 blockers was an independent risk factor for Candida parapsilosis.14 Exposure to gastric acid-suppression therapy is associated with health care- and community-associated Clostridium difficile infection in children.5,6 Transient and reversible changes in liver function tests may occur. In some infants, H2RA therapy causes irritability, head banging, headache, somnolence and other side effects which, if interpreted as persistent symptoms of GERD, could result in an inappropriate increase in dosage. Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children.13
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  Compatibility
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  Fluids: Glucose 5%, glucose 10%, Hartmann’s, sodium bicarbonate 4.2%, sodium chloride 0.9%
  Y-site: Aciclovir, adrenaline (epinephrine) hydrochloride, amifostine, aminophylline, anidulafungin, atracurium, aztreonam, bivalirudin, cefoxitin, ceftaroline fosamil, ciprofloxacin, cisatracurium, dexmedetomidine, dobutamine, dopamine, doripenem, esmolol, ethanol, filgrastim, fluconazole, foscarnet3, glyceryl trinitrate, granisetron, heparin sodium, labetalol, linezolid, lorazepam, midazolam, milrinone, pancuronium, piperacillin-tazobactam (EDTA-free), remifentanil, tigecycline, vecuronium, zidovudine
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