title: Dobutamine IV Infusion - Neonatal Intensive Care Drug Manual
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  Neonatal Intensive Care Drug Manual
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  bet | 183/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Dobutamine IV Infusion
  Revision Date : 18-2-2021
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  Approved : TC, KOH
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  Alert
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  In conditions with low systemic vascular resistance (SVR) (e.g., septic shock) dobutamine is not the appropriate first drug of choice
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  Indication
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  Inotrope to increase cardiac output in neonates with myocardial dysfunction and unchanged or increased systemic vascular resistance.
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  Action
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  Catecholamine with beta-1 and beta-2 receptor actions which increases myocardial contractility, heart rate and conduction velocity and decreases SVR 1.
  Dose dependent effects:
  • Low dose, 2.5 microgram/kg/min – no significant hemodynamic effects in neonates with cardiovascular compromise
  • Moderate dose, 5–7.5 microgram/kg/min – increases cardiac output
  • Higher dose, 5–20 microgram/kg/min – increases cardiac output and blood pressure in hypotensive preterm infants
  An additional effect of dobutamine on increasing cardiac output has been demonstrated in hypotensive preterm infants receiving dopamine.
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