title: Contraindications - Neonatal Intensive Care Drug Manual
text: Contraindications
  Known hypersensitivity to midazolam.
  Precautions
  In preterm infants, especially in extreme preterm, midazolam half-life is increased from 4−6 hours in term neonates up to 22 hours in premature infants. It is longer with impaired liver function.
  Caution when concurrently used with opioids − midazolam interacts with other central nervous system depressants and may increase the risk of drowsiness, respiratory depression and hypotension. Withdraw slowly after chronic administration as abrupt discontinuation may precipitate withdrawal seizures.
  Caution in neonates with renal and hepatic impairment − increased sensitivity to central nervous system (CNS) effects; use doses at lower end of the range.
  Rapid IV infusion may result in hypotension, respiratory depression or seizure.
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