title: Pharmacokinetics - Neonatal Intensive Care Drug Manual
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  Neonatal Intensive Care Drug Manual
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  bet | 573/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Pharmacokinetics: Sotalol is mainly excreted unchanged, renally.7 Sotalol is rapidly absorbed, with mean peak concentrations 2 to 3 hours after administration; half-life 7 to 9 hours.8 Neonates have variable oral absorption of sotalol resulting in two-fold variation in plasma concentrations compared to children.9 Neonates show a higher sensitivity toward QTc interval prolongation compared with older patients.5 QTc and RR interval prolongation are linearly related to the sotalol plasma concentration.7
  Safety:
  Side effects of sotalol reported in infants include prolongation of QTc interval, bradycardia/pauses, and torsades de pointes.
  ANZCOR treatment recommendations for polymorphic ventricular tachycardia (torsades de pointes): Cease medication associated with cause; correct electrolyte abnormalities; give magnesium 0.1–0.2 mmol/kg = 25–50 mg/kg IV.1
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