title: Pharmacokinetics - Neonatal Intensive Care Drug Manual
text: General
  There are no data from randomised controlled trials to recommend or refute the use of heparin for treatment of neonatal thrombosis.2
  Dose
  Antithrombotic prophylaxis
  Loading doses and maintenance doses have been adapted from the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines 2012,1 which were based on paediatric data from a prospective cohort study.22 (LOE IV GOR D)
  Loading dose is safer to be infused over 30 minutes in neonates. (ANMF haematology expert group opinion)
  Initial maintenance dose is easier to be administered at 30 units/kg/hr, rather than 28 units/kg/hr. (ANMF haematology expert group opinion)
  Central vascular catheters
  Heparin infusions at 0.5 units/kg per hour are recommended to maintain CVAD patency.1,7 (LOE I, GOR B)
  Peripheral arterial catheters
  Heparin infusions at 0.5 units/mL at 1 mL/hour are recommended.1 (LOE II, GOR B)
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