title: Drug interactions - Neonatal Intensive Care Drug Manual
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  Neonatal Intensive Care Drug Manual
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  bet | 261/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Drug interactions
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  Paracetamol, non-steroid anti-inflammatory drugs, alprostadil, thrombolytic agents, vitamin A may increase the risk of bleeding.
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  Adverse reactions
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  Haemorrhage and haematoma formation.
  Heparin-induced thrombocytopenia (HIT).
  Osteoporosis.
  Cholestatic liver reaction and elevation of transaminases.
  Hyperaldosteronism can occur after prolonged administration.8
  Treatment of Heparin-Induced Bleeding: (1) cease heparin and (2) if immediate reversal is required, administer protamine sulfate. The required dose of protamine sulfate is based on the amount of UFH received in the previous 2 hours as follows:1
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