title: Phenytoin - Neonatal Intensive Care Drug Manual
text: Phenytoin
  Revision Date : 16-12-2020
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  Approved : TC, KOH
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  Alert
  Rapid IV infusion can cause cardiovascular collapse. Phenytoin concentration is reported in mg/L.
  To convert mg/L (microgram/mL) to micromol/L:multiply by 3.964.
  Indication
  Treatment of neonatal seizures.1-4
  Action
  Inhibition of neuronal sodium influx, suppression of sodium action-potentials, inhibition of neuronal calcium influx, enhancement of GABA neurotransmission, and blockade of inotropic receptors for glutamic acid.
  Drug type
  Hydantoin derivative anticonvulsant
  Trade name
  Dilantin, DBL Phenytoin Injection, Phenytoin Sandoz Injection
  Dilantin Paediatric Suspension
  Presentation
  100 mg/2 mL ampoule
  30 mg/5 mL oral suspension
  Dose
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