title: Original version Date: 06/09/2017
text: Alert
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  Sotalol can prolong QTc interval. A 12-lead ECG is to be done before and after the commencement of sotalol (see adverse reactions section).
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  Indication
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  For the maintenance of sinus rhythm in conditions such as supraventricular tachycardia (SVT) and atrial tachycardia after consultation with cardiologist.
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  Action
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  Nonselective beta-blocking agent with class III effects at higher serum concentrations.
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  Drug Type
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  Antiarrhythmic.
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  Trade Name
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  Oral: Suspension prepared by pharmacy.
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  Presentation
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  Oral: 5 mg/mL suspension.
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  Dosage / Interval
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  If possible, treatment with the oral preparation is preferred.
  Oral: Starting dose 1 mg/kg/dose 12 hourly. Gradually increase every 3 to 4 days until adequate sinus rhythm is maintained. Doses greater than 4 mg/kg/day are best administered 8 hourly.
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  Maximum daily dose
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  4 mg/kg/day in neonatal period and 6 mg/kg/day beyond neonatal period. If dosing higher than this is being considered, consult a paediatric cardiologist.
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  Route
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  Oral
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  Preparation/Dilution
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  Oral: 5 mg/mL suspension (prepared by pharmacy).
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  Administration
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  Oral: Preferably administered on an empty stomach; at least 30 minutes before feeding.
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  Monitoring
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  Perform a 12 lead ECG before and after the first dose to assess for any increase in QTc interval from baseline. To be performed with the initial dose and after any increases in dose.
  For initiation of therapy and for intravenous treatment, infant should be on cardiorespiratory monitor.
  Monitor electrolytes, especially potassium and magnesium.
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