title: Dosage / Interval - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 222/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Dosage / Interval
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  IV or PO*: 1 to 2 mg/kg/dose. Dose interval as follows:
  Corrected gestational age/Postmenstrual age
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  Interval
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  Preterm infant ≤ 33 weeks
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  Every 24 hours
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  Preterm infant > 33 weeks
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  12–24 hours
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  Term infant 0–30 days
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  Every 12 hours
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  Term infant > 30 days
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  8–12 hours
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  *PO: Dose may be increased up to maximum 6 mg/kg/dose in term infants with heart failure.
  IV Infusion: 0.05 to 0.2 mg/kg/hour increased to maximum 0.4 mg/kg/hour if urine output < 1 mL/kg/hour.
  Diuresis renography: 1 mg/kg stat.
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  Maximum dose
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  IV: 2 mg/kg/dose
  IV infusion: 0.4 mg/kg/hour
  Oral: 6 mg/kg/dose
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  Route
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  IV or oral
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  Preparation/Dilution
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  IV bolus: Give undiluted. If dilution required draw up 0.5mL (5 mg of furosemide) and add 9.5mL sodium chloride 0.9% to make a final volume of 10 mL with a concentration of 0.5 mg/mL.
  IV infusion:
  Single-strength infusion: Draw up 0.5 mL/kg (5 mg/kg of furosemide) and make up to 10 mL with sodium chloride 0.9% or glucose 5% or glucose 10% or glucose 20% to make a 0.5 mg/kg/mL solution. Infusing at a rate of 0.1 mL/hour = 0.05 mg/kg/hour.
  Double-strength infusion: Draw up 1 mL/kg (10 mg/kg of furosemide) and make up to 10 mL with sodium chloride 0.9% or glucose 5% or glucose 10% or glucose 20% to make a 1 mg/kg/mL solution. Infusing at a rate of 0.1 mL/hour = 0.1 mg/kg/hour.
  Oral: Use as supplied undiluted.
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  Administration
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  IV bolus over 2–4 minutes: maximum rate not to exceed 0.5 mg/kg/minute or 4 mg/minute. For diuresis renography – dose should be given as a push.1
  IV infusion: Via syringe pump
  Oral: Solution may be administered without regard to feeds.
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  Monitoring
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  Urine output, weight, serum sodium and potassium. Screening for nephrocalcinosis may be required for preterm infants on prolonged therapy.
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