title: Creon forte 25,000 - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 420/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Creon forte 25,000: lipase, amylase, protease 25,000, 18,000, 1000
  Pancrease: lipase, amylase, protease 5,600, 3,200 350.
  Dilution :
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  Nil. Mix with a sugar free syrup or jam for administration on spoon.
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  Stability :
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  Do not administer with alkali or antacids
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  Storage :
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  Room temperature.
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  Compatibility:
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  Not Applicable.
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  Incompatibility :
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  Not Applicable.
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  Serum Levels :
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  Not Applicable.
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  Original version Date: 2014
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  Author: AK, JD
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  Current Version number: 2
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  Current Version Date: 30/12/2020
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  Risk Rating: Low
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  Due for Review: 30/12/2025
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  Approved by: DTC
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  Approval Date: TBA
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  Pancuronium |
  Revision Date : 2-3-2020
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  Approved: TC, KOH
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  Alert
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  High-alert medication: High risk of causing significant patient harm when used in error.
  This drug should be administered in the presence of personnel trained in advanced airway management.
  Suggest regular cessation of infusion for a few to several hours, possibly every 24 hours (commonly referred to as ‘drug holiday’7) to assess the need for continued paralysis and adequacy of sedation or analgesia.
  Line should be adequately flushed to avoid unintended paralysis during later use of the line.
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  Indication
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  1. Skeletal muscle relaxation or paralysis in mechanically ventilated infants
  2. For elective endotracheal intubation.
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  Action
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  Long acting non-depolarising muscle relaxant that competitively antagonises acetylcholine antagonist at nicotinic acetylcholine receptors at neuromuscular junctions. Also has autonomic anticholinergic effect resulting in increase in heart rate.
  Onset of action: 1–2 minutes. Duration of action: 45–60 minutes.
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  Drug Type
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  Long acting non-depolarising neuromuscular blocking agent.
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  Trade Name
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  Pancuronium Bromide Injection BP – Astra Zeneca
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  Presentation
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  Ampoules (Polyamp DuoFit), 4 mg/2 mL.
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