title: Reduction of side effects of opioids
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  Reduction of side effects of opioids
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  bet | 386/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Reduction of side effects of opioids: There are no trials in newborns specifically for this indication. There are case reports of response to naloxone in newborn infants with morphine-induced muscle rigidity and hypoxaemia during mechanical ventilation. [6, 7] In an RCT, low dose naloxone infusion 0.25 microgram/kg/hour did not decrease fentanyl requirements in critically ill, mechanically ventilated children aged 1 day to 18 years. [8] In 23 children aged 5 months to 18 years in intensive care receiving opioid therapy, enteral naloxone for treating constipation increased stool output but induced withdrawal symptoms. [9] Conclusion: There is no role for naloxone for reducing the side effects of opioids in newborn infants. (GOR B – evidence for harm)
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