title: Drug interactions - Neonatal Intensive Care Drug Manual
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  Neonatal Intensive Care Drug Manual
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  bet | 478/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Drug interactions
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  May potentially:
  Enhance the nephrotoxic effect of vancomycin.
  Affect the blood coagulation system when given with high doses of heparin and oral anticoagulants.
  Increase the serum concentration of flucloxacillin.
  Increase the prolongation of the neuromuscular blockade of vecuronium.
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  Adverse reactions
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  Generally well tolerated.
  Hypersensitivity reactions can occur.
  Rash (maculopapular), phlebitis, thrombophlebitis.
  Diarrhoea, nausea, vomiting, stomatitis and pseudomembranous colitis (Clostridium difficile).
  Black tongue, fever, anaphylactic shock, angioedema, bronchospasm.
  Leucopenia, thrombocytopenia, anaemia.
  Elevated transaminases.
  Renal impairment.
  Hypokalaemia, hypernatraemia, metabolic alkalosis.
  Candidiasis.
  High doses may lead to hypernatraemia (owing to sodium content of preparations)
  Uncommon - Hypotension.
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  Compatibility
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  Fluids: Sodium chloride 0.9%, glucose 5%, glucose 10%
  Y-site: EDTA-free brands only (NOT Tazocin EF): Amino acid solutions, aminophylline, anidulafungin, aztreonam, bivalirudin, buprenorphine, calcium folinate, calcium gluconate monohydrate, clindamycin, dexamethasone, dexmedetomidine, dopamine, fluconazole, furosemide (frusemide), granisetron, heparin sodium, hydrocortisone sodium succinate, hydromorphone, linezolid, magnesium sulfate heptahydrate, methylprednisolone sodium succinate, metoclopramide, metronidazole, morphine sulfate pentahydrate, pethidine, potassium chloride, ranitidine, remifentanil, tigecycline, trimethoprim + sulfamethoxazole, zidovudine.
  Y-site: Tazocin EF only: No information available.
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  Incompatibility
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  Fluids: Albumin, blood products, Hartmann’s and alkaline solutions. (AIDH)
  Y site: Aciclovir, albumin, amikacin, amiodarone, azithromycin, caspofungin, chlorpromazine, ciprofloxacin, dobutamine, droperidol, ganciclovir, gentamicin, glycopyrronium bromide (glycopyrrolate), haloperidol lactate, hydralazine, insulin (short-acting), labetalol, midazolam, mycophenolate mofetil, pentamidine isetionate, promethazine, rocuronium, sodium bicarbonate, thiopentone, tobramycin, tranexamic acid, vecuronium, verapamil.
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  Stability
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  Reconstituted solution is stable for 24 hours below 25°C or at 2−8°C. Immediate use is recommended.
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  Storage
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  Store vial below 25°C
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  Excipients
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  PiperTaz Sandoz, PipTaz AFT and Tazopip are EDTA-free. Contain 2.35 mmol of sodium for each 1 g of piperacillin.
  PipTaz AFT also contains sodium bicarbonate.
  Tazocin EF also contains citric acid monohydrate and disodium edetate (EDTA). Contains 2.84 mmol of sodium for each 1 g of piperacillin.
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