title: In syringe: Insulin NPH. 
      
  Incompatibility 
    
  Y-site administration
text: |
  In syringe: Insulin NPH.
  Incompatibility
  Y-site administration
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  bet | 318/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  In syringe: Insulin NPH.
  Incompatibility
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  Y-site administration: Cefoxitin; chlorpromazine; diazepam; diazoxide; dopamine; glycopyrronium bromide (glycopyrrolate); isoprenaline; ketamine; labetalol; noradrenaline (norepinephrine); phentolamine; phenylephrine; phenytoin; piperacillin sodium-tazobactam sodium; polymyxin; propranolol; protamine; quinidine; rocuronium; sulfamethoxazole-trimethoprim;
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  Stability
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  Actrapid: Prepared solutions are stable at room temperature (< 25°C) for 24 hours.
  Humulin R: Prepared infusions can be stored refrigerated for 48 hours and may be used at room temperature for an additional 48 hours.
  Novolin R: Prepared solutions are stable for 24 hours at room temperature [Micromedex].
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  Storage
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  Store human insulin preparations between 2 and 8°C. The shelf life is 30 months when stored between 2 and 8°C. Do not freeze. Human insulin preparations which have been frozen must not be used. Protect from excessive heat and light. Should appear clear and colourless. After first use, the vials may be kept at room temperature (below 25°C) for 4 weeks.
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  Special Comments
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  Insulin is incompatible with many drugs and hence should be administered via a single, dedicated line.
  Insulin is adsorbed to the plastic of intravenous bags, syringes, and tubing which reduces the delivery of insulin [3-5].
  Twenty mL of insulin priming solution at concentrations of 0.1 Unit/mL and 0.05 Unit/mL were found to deliver 80% and 26.5% of the expected insulin. Insulin concentrations ≤ 0.05 Unit/mL are not reliably delivered even after preconditioning and flushing [3,4].
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  Evidence summary
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  Efficacy
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