title: Contraindications - Neonatal Intensive Care Drug Manual
text: Significant acute illness or temperature greater than 38.5°C – postpone vaccine until neonatologist approves.
  If the infant has experienced an encephalopathy of unknown aetiology occurring within 7 days after previous vaccination with a pertussis containing vaccine.
  The following reactions to a previous dose may preclude further doses:
  - Convulsions within 3 days.
  - Persistent, severe, inconsolable screaming or crying for three or more hours within 48 hours.
  - Unexplained temperature > 40.5°C within 48 hours.
  Immunosuppressed patients
  Thrombocytopenia or bleeding disorders.
  Children who have had a hypotonic/hyporesponsive episode (HHE) within 48 hours of vaccination with a DTPa containing vaccine should receive further doses as advised by the Adverse Events after Immunisation Clinics.
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