title: Dosage/Interval - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 561/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Dosage/Interval
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  Severe hyponatraemia < 120 mmol/L or symptomatic hyponatraemia
  IV: CAUTION—CANNOT BE GIVEN UNDILUTED. REFER TO PREPARATION/DILUTION SECTION FOR DETAILS.
  Infuse sodium chloride at 0.4 mmol/kg/hour until symptoms abate or sodium ≥ 120 mmol/L.
  Then infuse sodium chloride at 0.15 mmol/kg/hour for 48 hours or until desired sodium is achieved.
  Therapeutic goal is to increase sodium by 7 mmol/L/day.
  IV supplementation
  Start at 2–4 mmol/kg/day and increase as required.
  Oral supplementation
  Start at 2–4 mmol/kg/day (0.6–1.2 mL/kg/day) and increase as required, divided into 3–12 doses.
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  Route
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  IV, PO
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  Maximum Dose
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  Preparation/Dilution
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  IV infusion:
  Draw up 5 mL (20 mmol sodium) of 23.4% sodium chloride and add 45 mL of WFI to make a final
  volume of 50 mL with a concentration of 0.4 mmol/mL. 1 mL/kg/hour = 0.4 mmol/kg/hour (9.6
  mmol/kg/day).
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