title: Fluconazole - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 215/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Fluconazole
  Revision Date : 13-1-2021
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  Approved : TC, KOH
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  Alert
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  The Antimicrobial Stewardship Team recommends this drug as: Restricted.
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  Indication
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  Treatment of systemic infection and meningitis caused by susceptible Candida species.
  Prophylaxis from Candida infection.
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  Action
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  Triazole antifungal which selectively inhibits fungal cytochrome P-450 sterol C-14 alpha demethylation.
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  Drug type
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  Antifungal.
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  Trade name
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  IV: Aspen Fluconazole, Diflucan, Fluconazole Alphapharm, Fluconazole Claris, Fluconazole Hexal, Fluconazole Sandoz, Fluconazole Solution (Baxter). ORAL: Diflucan
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  Presentation
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  IV: 2 mg/mL injection
  ORAL: 50 mg/ 5 mL powder for reconstitution
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  Dose
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  TREATMENT
  Loading dose: 25 mg/kg
  Maintenance dose: 12 mg/kg DAILY to start 24 hours after loading dose.
  The regimen without a loading dose may take up to 5 days to reach steady state. Steady state can be reached in 2 days if a loading dose is used.
  PROPHYLAXIS*
  6 mg/kg TWICE per week
  *Fluconazole prophylaxis may be considered in high risk infants following completion of treatment for Candida sepsis but still carrying risk of recurrence – e.g., presence of indwelling catheters and ongoing skin thrush.
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  Dose adjustment
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  No information.
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  Maximum dose
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