title: Presentation - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 208/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Presentation
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  IV:
  10 mg/mL injection.
  Oral:
  20 mg/mL suspension compounded by pharmacy.
  50 mg, 100 mg tablets.
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  Dose
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  Oral:
  Starting dose: 1 mg/kg/dose 8 or 12 hourly. Increase by 1 mg/kg/dose as necessary to achieve maintenance of sinus rhythm up to the maximum dose.
  IV:
  2 mg/kg over at least 10 minutes.
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  Dose adjustment
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  No information.
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  Maximum dose
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  8 mg/kg/day
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  Total cumulative dose
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  Route
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  Oral [preferred route] or IV
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  Preparation (for IV administration)
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  Draw up 1mL (10mg of flecainide) and add 9mL of glucose 5% to make a final volume of 10 mL with a concentration of 1mg/mL.
  It can also be administered undiluted.
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  Administration
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  Oral:
  Administer between milk feeds. Do not administer with milk. Milk decreases absorption of the drug.
  IV:
  Infusion over at least 10 minutes. Patient needs to be monitored very closely with the potential for an acute deterioration.
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  Monitoring
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  Initiate treatment in hospital with ECG monitoring in consultation with paediatric cardiologist.
  When intravenous route is used, continuous ECG monitoring is mandatory.
  Perform ECG when the dosage is increased – monitor QRS duration and dysrhythmia.
  Therapeutic trough concentrations are not routinely required (200–1000 microgram/L).
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