title: Drug interactions - Neonatal Intensive Care Drug Manual
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  Neonatal Intensive Care Drug Manual
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  bet | 217/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Drug interactions
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  Erythromycin: Concurrent use increases the risk of cardiotoxicity (prolonged QT interval, torsades des pointes); therefore avoid combination.
  Barbiturates, caffeine, benzodiazepines and phenytoin: Serum concentrations increased by fluconazole, consider dose reduction and therapeutic drug monitoring where available.
  Hydrochlorothiazide: Increases fluconazole serum concentration, consider dose reduction of fluconazole.
  Zidovudine: Concentrations are increased by fluconazole; monitor for adverse reactions (anaemia, neutropenia) and extend dose interval.
  Cisapride: May precipitate arrhythmias, therefore contraindicated.
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