title: Reversal of opioid effect to facilitate extubation
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  Reversal of opioid effect to facilitate extubation
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  bet | 385/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Reversal of opioid effect to facilitate extubation: A single case series reported the outcomes of 31 infants with a mean birth weight of 1178 grams and mean gestational age 28.4 weeks who were intubated after IV atropine 0.02 mg/kg, fentanyl 3 micrograms/kg and succinylcholine 2 mg/kg for surfactant administration. Infants with an adequate respiratory drive were immediately extubated while those with apnoea or hypopnoeaa received naloxone 0.1 mg/kg/dose, repeated if needed. Twelve of thirteen (92%) infants in the naloxone group were extubated within 30 minutes of surfactant administration while 12/18 (67%) in the non-naloxone group were extubated within the same time frame. No adverse reactions were noted.[4] Conclusion: Naloxone may be effective in reversing the respiratory depression from opioid administration and facilitate extubation in preterm infants intubated for the InSurE procedure. Clinical trials are required to confirm this finding and its safety. (LOE IV GOR D).
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