title: Contraindications - Neonatal Intensive Care Drug Manual
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  Neonatal Intensive Care Drug Manual
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  bet | 449/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Contraindications
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  Hypersensitivity to phenobarbital or any ingredients. Any forms of acute porphyria.
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  Precautions
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  Use with caution in renal or hepatic impairment.
  Dependence may develop with prolonged use – consider weaning instead of abrupt withdrawal (Refer to special comments section).
  Therapeutic hypothermia may increase the serum concentrations of phenobarbital
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  Drug interactions
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  Morphine, fentanyl, midazolam and other CNS depressants may have an additive effect with phenobarbital in causing respiratory depression. Consider starting phenobarbital at the lower end of the dose range in these patients. Blood concentrations of digoxin, metronidazole, corticosteroids (e.g. betamethasone, dexamethasone), vitamin D, and beta-blockers (e.g. propranolol, sotalol) may be reduced if administered concurrently with phenobarbital. Concurrent administration of phenytoin with phenobarbital has variable effects on serum concentrations of either drug. Serum concentrations should be monitored for both drugs.
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