title: Phenobarbitone - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 446/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Phenobarbitone
  Revision Date : 16-11-2020
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  Approved: TC, KOH
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  Alert
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  S4 – High risk medicine.
  Phenobarbital is reported in mg/L. To convert to micromol/L, multiply by 4.306.
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  Indication
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  Treatment of neonatal seizures.
  Initial treatment of non-opioid neonatal abstinence syndrome (NAS).
  Add-on treatment of opioid NAS uncontrolled by morphine at maximum dose (if 3 consecutive NAS scores average ≥ 8 or 2 consecutive NAS scores average ≥12).
  Treatment of hyperbilirubinaemia (unclear role).
  Treatment of cholestasis (unclear role).
  Preparation for liver scintigraphy (unclear role).
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  Action
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  Enhances inhibitory neurotransmission via activation of GABA receptor.
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