title: Morphine Oral - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 371/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Morphine Oral
  Revision Date : 27-6-2019
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  Approved : TC, KOH
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  Alert
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  S8 – High-risk medication – may cause significant patient harm when used in error.
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  Indication
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  Analgesia/sedation:
  During assisted ventilation
  During procedures and post-surgery
  Neonatal abstinence syndrome secondary to opioids
  Analgesia and relief of dyspnoea including in context of palliative care
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  Action
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  Opioid analgesic − stimulates the μ-δ-opioid (Mu-Delta) receptor heteromer in the central nervous system.
  Modulates neurotransmitters.
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  Drug Type
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  Opioid analgesic.
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  Trade Name
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  Ordine (Morphine HYDROCHLORIDE).
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  Presentation
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  1 mg/mL oral solution of morphine HYDROCHLORIDE.
  Also commercially available as 2 mg/mL, 5 mg/mL and 10 mg/mL oral solution.
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  Dosage/Interval
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  Neonatal abstinence syndrome secondary to maternal opioid dependency:
  Starting dose: 0.5 mg/kg/day divided into 4–6 equal divided doses.
  Increase dose by 10−25% titrated to Neonatal Abstinence Syndrome scores (aiming for scores < 8) and clinical condition.
  Decrease dose by 10–25% every 2–4 days titrated to Neonatal Abstinence Syndrome scores (when scores ≤ 4) and clinical condition.
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