title: Total cumulative dose - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 216/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Total cumulative dose
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  Route
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  IV, Oral
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  Preparation
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  IV: Administer 2 mg/mL injection −no dilution necessary.
  Oral: Powder normally reconstituted by Pharmacy. If supplied as dry powder, reconstitute using water for injection with the volume specified on the bottle.
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  Administration
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  IV: Infusion over 30 minutes.
  Oral: Can be given with feeds. Shake reconstituted bottle well before drawing up dose.
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  Monitoring
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  Serum creatinine prior to starting therapy.
  Liver function, renal function and full blood count.
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  Contraindications
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  Cardiac rhythm problems as fluconazole may increase QT interval.
  Hypersensitivity to fluconazole or other constituents.
  Concurrent therapy with other drugs known to prolong the QT interval and those drugs which are metabolised via the enzyme CYP3A4 e.g., cisapride, erythromycin.
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  Precautions
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  Consider extending dose interval to 48 hourly if creatinine > 115 micromol/L.
  Use with caution in hepatic impairment.
  May precipitate or worsen hyperbilirubinaemia, use with caution.
  May increase QT interval.
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