title: Contraindications - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 209/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Contraindications
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  Cardiogenic shock.
  Hypersensitivity to flecainide.
  Significant renal impairment (creatinine clearance < 50 mL/min).
  Reduced left ventricular ejection fraction.
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  Precautions
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  Use with caution in patients with congenital heart disease or conduction system disease (right bundle branch block, with left hemiblock and without pacemaker; second- or third-degree atrioventricular block, without pacemaker; sick sinus syndrome [bradycardia-tachycardia syndrome]).
  Milk decreases oral flecainide absorption. Consider decreasing oral dose or dose monitoring if change of milk diet.
  Dosing adjustments are required in infants with renal impairment because 10% to 50% of a flecainide dose is excreted in the urine.
  Use with caution in significant hepatic impairment.
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