title: Special comments - Neonatal Intensive Care Drug Manual
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  Neonatal Intensive Care Drug Manual
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  bet | 164/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Special comments
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  Concomitant use of a thiazide diuretic is recommended to counter sodium and fluid retention from use of diazoxide.4, 5
  Oral diazoxide preparations are not registered in Australia. Complete a Special Access Scheme - Category C form and obtain parental consent.
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  Evidence
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  Efficacy: There are no clinical trials of diazoxide for management of hyperinsulinaemic hypoglycaemia. Transient and syndromic hyperinsulinaemic hypoglycaemia tends to be diazoxide responsive, whereas other genetic forms affecting the K-ATP channel and incretin receptors, and infants with insulinomas, are variably responsive.2-4, 6-9 (LOE IV, GOR C)
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