title: Pulmonary hypertension - Neonatal Intensive Care Drug Manual
text: Pulmonary hypertension:
  Loading dose of 200 mg magnesium sulfate/kg IV over 60 minutes followed by continuous IV infusion 20–50 mg/kg/hour (target serum magnesium between 3.5 and 5.5 mmol/L)
  Perinatal asphyxia
  250 mg magnesium sulfate/kg/dose of over 1 hour to be commenced within 6 hours of birth. Total 3 doses at 24 hour intervals.
  Torsades de pointes with pulse
  25-50 mg magnesium sulfate/kg IV over 15–20 minutes.
  Pulseless torsades de pointes
  25–50 mg magnesium sulfate/kg IV/Intraosseous (IO) over several minutes.
  Intramuscular Route (Emergency management of Neonatal tetany/convulsions/Hypocalcaemic convulsion when no IV access)
  IM: 100 mg magnesium sulfate/kg (0.2 mL/kg of 50% magnesium sulfate). Can be repeated 12 hourly.
  Route
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  IV, IM, oral, Intraosseous.
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