title: Drug interactions - Neonatal Intensive Care Drug Manual
text: Diuretics – Ibuprofen may reduce the effect of diuretics; whilst the diuretic may increase the risk of nephrotoxicity of NSAIDs in dehydrated patients.
  Anticoagulants – ibuprofen may increase the effect of anticoagulants and enhance the risk of bleeding.
  Nitric oxide – as both medicinal products have an inhibitory effect on platelet function, their combination may in theory increase the risk of bleeding.
  Corticosteroids – ibuprofen may increase the risk of gastrointestinal bleeding.
  Other NSAIDs – the concomitant use of more than one NSAID may increase risk of adverse reactions.
  Aminoglycosides – since ibuprofen may decrease the clearance of aminoglycosides, their co-administration may increase the risk of nephrotoxicity and ototoxicity.
  Fluconazole - Metabolism of ibuprofen may be inhibited, increasing its concentration.
  Systemic corticosteroids - Intestinal perforation has been described in infants treated with early dexamethasone and indomethacin. Although not described with ibuprofen, caution is advised.
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