title: Contraindications - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 374/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Contraindications
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  Hypersensitivity to morphine hydrochloride or any component.
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  Precautions
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  Opioid-naïve infants are at risk of cardiorespiratory depression, particularly if they are breathing spontaneously.
  Use with caution in patients with hypersensitivity reactions to other opioids.
  Hypotension and bradycardia.
  Transient hypertonia.
  Ileus and delayed gastric emptying time.
  Urinary retention.
  Tolerance may develop after prolonged use − wean slowly.
  Convulsions.
  Renal or hepatic impairment – affect metabolism and excretion.
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  Drug Interactions
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  Concomitant use with other CNS depressants potentiates effects of opioids, increasing risk of respiratory depression, profound sedation or coma.
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