title: Contraindications - Neonatal Intensive Care Drug Manual
text: Contraindications
  Liver disease.
  Precautions
  Short- and long-term safety data in infants are limited but there have been several safety concerns with long term usage in adults. Current FDA’s maximum recommended duration of therapy of PPIs is up to 8 weeks.
  Drug Interactions
  Concurrent use of ketoconazole may result in decreased ketoconazole exposure.
  Concurrent use of ampicillin may result in loss of ampicillin efficacy.
  Adverse Reactions
  Limited data available, though appears well tolerated and to have few side effects. Uncommon reports of nausea, vomiting and skin rash.
  Reported adverse events in adults:
  Abdominal pain (3% ), diarrhea (4% ), flatulence (4% )
  Neurologic: Headache (5% )
  Atrophic gastritis, Clostridium difficile diarrhea
  Haematological: Thrombocytopenia (less than 1% )
  Immunological: Stevens-Johnson syndrome, toxic epidermal necrolysis
  Musculoskeletal:, fracture of bone, osteoporosis-related hip fracture, rhabdomyolysis
  Renal: Interstitial nephritis, acute
  Compatibility
  Fluids: Glucose 5%, glucose 10%, sodium chloride 0.9%.
  Y site: Acetazolamide, alprostadil, aminophylline, amoxicillin sodium-clavulanate, amphotericin B phospholipid complex, amphotericin B liposomal, ampicillin, azithromycin, ceftriaxone, ganciclovir, imipenem-cilastatin, penicillin G, piperacillin, potassium chloride, theophylline, ticarcillin disodium, ticarcillin disodium-clavulanate, vasopressin, zidovudine.
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