title: Contraindications - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 232/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Contraindications
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  Hypersensitivity to ganciclovir, valganciclovir, aciclovir or valacyclovir.
  Patients with:
  absolute neutrophil count below 0.5 x 109/L or
  platelet count below 25 x 109/L unless thrombocytopenia is related to CMV disease, or
  haemoglobin less than 80 g/L (8 g/dL).
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  Precautions
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  Ganciclovir has both gonadal toxicity and carcinogenicity in animal models and its long-term safety after administration to young children is not established.1
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  Drug interactions
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  Convulsions have been reported in patients receiving ganciclovir and imipenem-cilastatin concurrently.
  Concurrent use of tacrolimus and ganciclovir increases nephrotoxicity.
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