title: Dosage/Interval - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 421/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Dosage/Interval
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  Muscle relaxation
  IV bolus: 0.1 mg/kg followed by
  Either IV infusion 0.05 mg/kg/hour (0.025–0.075 mg/kg/hour) OR
  Intermittent IV bolus 0.05 mg/kg (0.05–0.1 mg/kg) every 1–2 hours.
  Note: IV infusion dose can be increased or decreased by 0.01 mg/kg/hour to a maximum of 0.1 mg/kg/hour.
  Intubation
  IV bolus: 0.1 mg/kg.
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  Maximum dose
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  IV bolus: 0.1 mg/kilogram/dose.
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  Route
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  IV
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  Preparation/Dilution
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  IV bolus:
  Draw up 2 mL (4 mg of pancuronium) and add 6 mL water for injection to make a final volume of 8 mL with a concentration of 0.5 mg/mL
  IV infusion:
  Infusion rate
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  Prescribed amount
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  1 mL/hour = 50 microgram/kg/hour
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  2.5 mg/kg of pancuronium and make up to 50 mL
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  Draw up 1.25 mL/kg (2.5 mg/kg of pancuronium) and add sodium chloride 0.9% to make a final volume of 50 mL. Infusing at a rate of 1 mL/hour = 50 microgram/kg/hour.
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  Administration
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  IV bolus: Administer as a rapid intravenous injection over several seconds.
  Line should be adequately flushed to avoid unintended paralysis during later use of the line.
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  Monitoring
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  Continuous cardio-respiratory and pulse oximetry monitoring. Close monitoring of neuromuscular function, sedation and blood pressure (invasive or non-invasive) is essential. Monitoring of fluid balance is essential due to of risk of fluid retention. Monitor hepatic and renal function with prolonged use.
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