title: Contraindications - Neonatal Intensive Care Drug Manual
text: |
  Neonatal Intensive Care Drug Manual
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  bet | 365/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Contraindications
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  Severe obstructive aortic or pulmonary valvular disease or hypertrophic subaortic stenosis. Hypersensitivity to milrinone, other 3,4'-bipyridines (inamrinone) or any other ingredient of the formulation.
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  Precautions
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  Ensure adequate circulating blood volume prior to commencement.
  Loading dose: Considered optional depending on clinical circumstances. May cause hypotension. Monitor BP and heart rate closely and ensure adequate volume replacement.
  Prematurity: Long half-life reported (10 hours) in very preterm infants.5 Avoid prolonged higher rate infusion ≥0.2 microgram/kg/minute.
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