title: Paracetamol - Neonatal Intensive Care Drug Manual
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  Neonatal Intensive Care Drug Manual
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  bet | 435/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Paracetamol
  Revision Date : 18-2-2021
  TC, KOH
  Alert
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  Intravenous paracetamol should be considered a high-risk medicine when administered to infants and young children.
  Use of paracetamol should always be preceded by a comprehensive risk assessment and reviewed every 24 hours.
  Safety data for paracetamol in extreme preterm infants (< 28 weeks) is limited. It should be used with caution, particularly in the treatment of patent ductus arteriosus.
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  Indication
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  Analgesia
  Antipyretic
  Adjunct to post-operative analgesia
  Treatment of patent ductus arteriosus (PDA)
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  Action
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  Centrally acting analgesic and antipyretic with minimal anti-inflammatory properties. The mechanism of action of paracetamol in reducing pain is not completely defined. Potential mechanisms include inhibition of central prostaglandin synthesis and inhibition of the cyclooxygenase (COX) isoenzyme, particularly the COX-2 isoform.
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