title: Infants with post-haemorrhagic ventricular dilatation
text: The bioavailability of oral furosemide markedly reduced in preterm infants – estimated at 20%15 compared to ~60% in adults.16 94% is plasma protein bound.15 (LOE IV GOR C)
  Furosemide is primarily cleared via renal secretion (60–70%).16 Clearance is reduced in renal impairment.
  Safety: Furosemide results in renal excretion of calcium, sodium, chloride and potassium.17 Prolonged and high dose use of furosemide, especially in the context of other ototoxic treatments (including aminoglycosides), has been associated with ototoxicity.18–20 Blood concentrations exceeding 0.05 mg/mL may be associated with ototoxicity.14 (LOE III-2 GOR B). Prolonged furosemide treatment and treatment combined with acetazolamide is associated with nephrocalcinosis.10, 21 (LOE I GOR B)
  Alternate day furosemide may be associated with a lower risk of electrolyte and mineral abnormalities.23
  References
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