title: Post-operative apnoeas in preterm infants
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  Post-operative apnoeas in preterm infants
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  bet | 387/654 | Sana | 03.01.2022 | Hajmi | 1,5 Mb. | | #14803 |
  Post-operative apnoeas in preterm infants: The combined effect of anaesthetics and prematurity, each of which itself results in raised endorphin activity, may result in apnoeas in preterm infants in the perioperative period. Naloxone at a dose of 5–10 microgram/kg has been used to reverse respiratory effects of anaesthetics and narcotics in the post-operative period.[14–16]
  Safety: There are few data regarding adverse effects of naloxone in newborn infants. There is concern regarding precipitating opioid withdrawal in patients with prolonged opioid exposure.[1, 2] Naloxone should not be administered to babies whose mothers are known or suspected to be addicted to opioids. In such cases, an abrupt and complete reversal of opioid effects may precipitate an acute withdrawal syndrome.[3,17] There is a case report of
  a preterm neonate who developed cardiac arrest following treatment with naloxone (dose 100 mcg/kg) for a ten-fold morphine overdose.[18]
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