title: Pharmacokinetics - Neonatal Intensive Care Drug Manual
text: Practice points
  |
  There are safer and more effective interventions including insulin-glucose infusion and albuterol infusion to treat hyperkalaemia. (1)
  Resonium preparation in sorbitol enemas are hypertonic and associated with intestinal complications including necrosis and perforation. (6-9)
  To reduce the likelihood of intestinal complications, evacuation of rectal Resonium by irrigation with either glycerine or 1 to 2 mL of 0.9% sodium chloride can be performed. (10, 11)
  In children and neonates particular care should be observed with rectal administration, as excessive dosage or inadequate dilution could result in impaction of the resin.
  Due to the risk of digestive haemorrhage, colic necrosis or sodium overload, particular care should be observed in premature infants or low birth weight infants.
  |