In humans, the AR gene, located on the X chromosome at Xq11-12, may affect penis size. The SRY gene located on the Y chromosome may have a role to play. Variance in size can often be attributed to de novo mutations. Deficiency of pituitary growth hormone or gonadotropins or mild degrees of androgen insensitivity can cause small penis size in males and can be addressed with growth hormone or testosterone treatment in early childhood. Conditions
An adult penis with an erect length of less than 7 cm or 2.76 inches but otherwise formed normally is referred to in a medical context as having the micropenis condition. The condition affects 0.6% of men. Some of the identifiable causes are deficiency of pituitary growth hormone or gonadotropins, mild degrees of androgen insensitivity, a variety of genetic syndromes and variations in certain homeobox genes. Some types of micropenis can be addressed with growth hormone or testosterone treatment in early childhood. Operations are also available to increase penis size in cases of micropenis in adults. Environmental influence
It has been suggested that differences in penis size between individuals are caused not only by genetics, but also by environmental factors such as culture, diet and chemical or pollution exposure. Endocrine disruption resulting from chemical exposure has been linked to genital deformation in both sexes (among many other problems). Chemicals from both synthetic (e.g., pesticides, anti-bacterial triclosan, plasticizers for plastics) and natural (e.g., chemicals found in tea tree oil and lavender oil) sources have been linked to various degrees of endocrine disruption.
They found a few statistically significant Spearmans correlations: between flaccid length and height of 0.208, −0.140 with weight, and −0.238 with BMI, flaccid circumference and height 0.156, stretched length and height 0.221, weight −0.136, BMI −0.169. They also reported a few non-significant correlations. Erect
Scientific studies have been performed on the erect length of the adult penis. Studies that have relied on self-measurement, including those from Internet surveys, consistently reported a higher average length than those that used medical or scientific methods to obtain measurements.The following staff-measured studies are composed of different subgroups of the human population (in other words, specific age range or race; selection of those with sexual medical concerns or self-selection) that could cause a sample bias. In a study of 80 healthy males published in the September 1996 Journal of Urology an average erect penis length of 12.9 cm (5.1 in) was measured. The purpose of the study was to "provide guidelines of penile length and circumference to assist in counseling patients considering penile augmentation." Erection was pharmacologically induced in 80 physically normal American men (varying ethnicity, average age 54). It was concluded: "Neither patient age nor size of the flaccid penis accurately predicted erectile length." A study published in the December 2000 International Journal of Impotence Research found that average erect penis length in 50 Jewish Caucasian males was 13.6 cm (5.4 in) (measured by staff). The study intended "to identify clinical and engineering parameters of the flaccid penis for prediction of penile size during erection."