Transdermal patches providing a combination of 50 μg/day estradiol and 0.14 or 0.25 mg/day NETA are available under the brand names CombiPatch and Estalis.NETA was previously available for use by intramuscular injection in the form of ampoules containing 20 mg NETA, 5 mg estradiol benzoate, 8 mg estradiol valerate, and 180 mg testosterone enanthate in oil solution under the brand name Ablacton to suppress lactation in postpartum women. Contraindications
Side effects
Side effects of NETA include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and others. Overdose
Interactions
Pharmacology
NETA is a prodrug of norethisterone in the body. Upon oral ingestion, it is rapidly converted into norethisterone by esterases during intestinal and first-pass hepatic metabolism. Hence, as a prodrug of norethisterone, NETA has essentially the same effects, acting as a potent progestogen with additional weak androgenic and estrogenic activity (the latter via its metabolite ethinylestradiol).In terms of dosage equivalence, norethisterone and NETA are typically used at respective dosages of 0.35 mg/day and 0.6 mg/day as progestogen-only contraceptives, and at respective dosages of 0.5–1 mg/day and 1–1.5 mg/day in combination with ethinylestradiol in combined oral contraceptives. Conversely, the two drugs have been used at about the same dosages in menopausal hormone therapy for the treatment of menopausal symptoms. NETA is of about 12% higher molecular weight than norethisterone due to the presence of its C17β acetate ester.Micronization of NETA has been found to increase its potency by several-fold in animals and women.
The following are a few references to stories including a character who does not speak despite being physically able to. In the book Cut by Patricia McCormick, the main character, Callie, is an elective mute. In The House of the Spirits by Isabel Allende, Clara Trueba is mute after witnessing her sisters molestation and autopsy. "She could not move until the first lights of dawn appeared. Only then did she slip back into her bed, feeling within her the silence of the entire world. Silence filled her utterly." In Hannibal Rising by Thomas Harris, Hannibal Lecter is mute after witnessing his sister killed and eaten. In the book Flying Solo, the character Rachel is mute for six months after a classmate dies. In The Piano, Ada is an elective mute. She chooses to learn to speak at the end of the film. In the 1993 movie, House of Cards, Sally Matthews chooses not to speak after her father dies. In the book Halo: Ghosts of Onyx, Lucy-B091 is mute after she is one of only two survivors from her unit of 300. In the movie The Prophet Kamilas daughter, Elmitra, is depicted as mute after the death of her father. In the 2014 video game Watch Dogs, Aiden Pearces nephew, Jackson, is electively mute after the death of his sister.