Each mL of brexanolone solution contains 5 mg allopregnanolone, 250 mg sulfobutyl ether β-cyclodextrin, 0.265 mg citric acid monohydrate, 2.57 mg sodium citrate dihydrate, and water for injection. The solution is hypertonic and must be diluted to a target concentration of 1 mg/mL with sterile water and sodium chloride prior to administration. Five infusion bags are generally required for the full infusion. More than five infusion bags are necessary for patients weighing more than 90 kg (200 lbs). Research
Brexanolone was under development as an intravenously administered medication for the treatment of major depressive disorder, super-refractory status epilepticus, and essential tremor, but development for these indications was discontinued.Exogenous progesterone, such as oral progesterone, elevates allopregnanolone levels in the body with good dose-to-serum level correlations. Due to this, it has been suggested that oral progesterone could be described as a prodrug of sorts for allopregnanolone. As a result, there has been some interest in using oral progesterone to treat catamenial epilepsy, as well as other menstrual cycle-related and neurosteroid-associated conditions. In addition to oral progesterone, oral pregnenolone has also been found to act as a prodrug of allopregnanolone, though also of pregnenolone sulfate. References
Further reading
External links
"Brexanolone". Drug Information Portal. U.S. National Library of Medicine.
In addition to the issue of lindane pollution, some concerns are related to the other isomers of HCH, namely alpha-HCH and beta-HCH, which are notably more toxic than lindane, lack its insecticidal properties, and are byproducts of lindane production. In the 1940s and 1950s, lindane producers stockpiled these isomers in open heaps, which led to ground and water contamination. The International HCH and Pesticide Forum has since been established to bring together experts to address the clean-up and containment of these sites. Modern manufacturing standards for lindane involve the treatment and conversion of waste isomers to less toxic industrial chemicals, a process known as "cracking". Today, only a few production plants remain active worldwide to accommodate public-health uses of lindane and declining agricultural needs. Lindane has not been manufactured in the U.S. since the mid-1970s, but continues to be imported. See also
Benzene hexachloride (disambiguation)

References
External links
Government and organizations
FDA Information on Lindane
EPA Information on Lindane
Gamma Hexachlorocyclohexane Fact Sheet
Agency for Toxics and Disease Registry: Toxicological Profile for Hexachlorocyclohexane
Lindane in the Pesticide Properties DataBase (PPDB)
World Health Organization Background Document on Lindane for Drinking-Water Quality Guidelines
Lindane Chemistry and Uses
World Health Organization: Lindane (EHC 124)
"Lindane Facts" - Website run by Morton Grove Pharmaceuticals
U.S. National Library of Medicine: Hazardous Substances Databank – Lindane

News stories and opinion articles
"Mom and Pros Tackle Lice" - NPR story from 2006
Pepsi and Coca-Cola - Lindane in drinks in India - news story from 2006
India - Pesticides in Coke & Pepsi drinks - news story from 2003