Increased expression of ICAM-1 has been observed within the inflamed intestinal mucosa of people with ulcerative colitis, pouchitis and Crohns, where ICAM-1 over production correlated with disease activity. This suggests that ICAM-1 is a potential therapeutic target in the treatment of these diseases.Cannabinoid CB2 receptor agonists are found to decrease the induction of ICAM-1 and VCAM-1 surface expression in human brain tissues and primary human brain endothelial cells (BMVEC) exposed to various pro-inflammatory mediators.In 2014, an alliance among the Broad Institute, Amgen and Massachusetts General Hospital formed with the intention to "collect and analyze patient DNA samples to identify and further validate genetic targets. "In 2015, a meta-analysis on 938 IBD patients and 953 controls, IBD was significantly associated with having higher odds of vitamin D deficiency.Gram-positive bacteria present in the lumen could be associated with extending the time of relapse for ulcerative colitis.Bidirectional pathways between depression and IBD have been suggested  and psychological processes have been demonstrated to influence self-perceived physical and psychological health over time. IBD-disease activity may impact quality of life and over time may significantly affect individuals mental well-being, which may be related to the increased risk to develop anxiety and/or depression. On the other hand, psychological distress may also influence IBD activity.Higher rates of anxiety and depression are observed among those with IBD compared to healthy individuals, which correlated with disease severity. Moreover, anxiety and depression rates increase during active disease compared with inactive phases. See also
Inflammatory bowel disease-22
World Inflammatory Bowel Disease Day

References
External links
Inflammatory bowel disease at Curlie
Brand names
Brand names of nortriptyline include Allegron, Aventyl, Noritren, Norpress, Nortrilen, Norventyl, Norzepine, Pamelor, and Sensoval, among many others. References
External links
"Nortriptyline". Drug Information Portal. U.S. National Library of Medicine.