Hailey–Hailey disease, or familial benign chronic pemphigus: 559  or familial benign pemphigus,: 622  was originally described by the Hailey brothers (Hugh Edward and William Howard) in 1939. It is a genetic disorder that causes blisters to form on the skin. Signs and symptoms
HHD is characterized by outbreaks of rashes and blisters on the skin. Affected areas of skin undergo repeated blistering and inflammation, and may be painful to the touch. Areas where the skin folds, as well as the armpits, groin, neck, buttocks and under the breasts are most commonly affected. In addition to blistering, other symptoms which accompany HHD include acantholysis, erythema and hyperkeratosis. Causes
The cause of the disease is a haploinsufficiency of the enzyme ATP2C1; the ATP2C1 gene is located on chromosome 3, which encodes the protein hSPCA1. A mutation on one copy of the gene causes only half of this necessary protein to be made and the cells of the skin do not adhere together properly due to malformation of intercellular desmosomes, causing acantholysis, blisters and rashes. There is no known cure. Diagnosis
Classification
While the term pemphigus typically refers to "a rare group of blistering autoimmune diseases" affecting "the skin and mucous membranes", Hailey–Hailey disease is not an autoimmune disorder and there are no autoantibodies. According to Pemphigus Pemphigoid Foundation (IPPF), "familial benign chronic pemphigus, or Hailey-Hailey disease, is a different condition from Pemphigus". Differential diagnosis
The differential diagnosis includes intertrigo, candidiasis, frictional or contact dermatitis, and inverse psoriasis. A biopsy and/or family history can confirm.
One-day cricket
an abbreviated form of the game, with just one innings per team, usually with a limited number of overs and played over one day. One Day International (ODI)
a match between two national sides limited to 50 overs per innings, played over at most one day. One down
a batsman who bats at No. 3 i.e. when the team is "down by one wicket", a crucial position in the teams batting innings. One short
when a batsman fails to make contact with the ground beyond the popping crease, and turns back for an additional run. Opener
1.  an opening batsman
2.  an opening bowler

Opening batsman
One of the two batsmen who are in at the start of the innings. They must face the opening bowlers and new ball, so require good defensive technique to avoid getting out, especially in a timed match. In a limited overs match an opening batsman must also score quickly during the power play. Opening bowler
One of the two bowlers who begin the innings using the new ball. They are usually the fastest or most aggressive bowlers in the side. Opposite number
A player on the other team who plays the same role. Often used for captains and wicket keepers. Orthodox
1.  shots played in the accepted "textbook" manner, and batsmen who play in this manner. 2.  see left-arm orthodox spin. Out
1.  the state of a batsman who has been dismissed.