Epidemiology
Incidence of Sanfilippo syndrome varies geographically, with approximately 1 case per 280,000 live births in Northern Ireland, 1 per 66,000 in Australia, and 1 per 50,000 in the Netherlands.The Australian study estimated the following incidence for each subtype of Sanfilippo syndrome:

History
The condition is named after Sylvester Sanfilippo, the pediatrician who first described the disease in 1963. Caregiver impact
Caregivers for children with Sanfilippo syndrome face a unique set of challenges because of the diseases complex nature. There is little understanding among clinicians of the family experience of caring for patients with Sanfilippo and how a caregivers experiences change and evolve as patients age. The burden and impact on caregivers quality of life is poorly defined and best-practice guidance for clinicians is lacking.A best-practice guidance to help clinicians understand the challenges caregivers face was published July 2019 in the Orphanet Journal of Rare Diseases by a group of international clinical advisors with expertise in the care of pediatric patients with Sanfilippo, lysosomal storage disorders, and life as a caregiver to a child with Sanfilippo.The group reviewed key aspects of caregiver burden associated with Sanfilippo B by identifying and quantifying the nature and impact of the disease on patients and caregivers. Recommendations were based on findings from qualitative and quantitative research.The articles authors reported, "Providing care for patients with Sanfilippo B impinges on all aspects of family life, evolving as the patient ages and the disease progresses.
Tuberculoid leprosy is a form of leprosy characterized by solitary skin lesions that are asymmetrically distributed with few lesions and well demarcated edges. There is also early and marked nerve damage. It tends to heal spontaneously. : 345  Tuberculoid leprosy is characterized by the formation of epithelioid cell granulomas with a large number of epithelioid cells. In this form of leprosy Mycobacterium leprae are either absent from the lesion or occur in very small numbers. This type of leprosy is the most benign and the least contagious. See also
Leprosy
Skin lesion

References


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