Natamycin, also known as pimaricin, is an antifungal medication used to treat fungal infections around the eye. This includes infections of the eyelids, conjunctiva, and cornea. It is used as eyedrops. Natamycin is also used in the food industry as a preservative.Allergic reactions may occur. It is unclear if medical use during pregnancy or breastfeeding is safe. It is in the macrolide and polyene families of medications. It results in fungal death by altering the cell membrane.Natamycin was discovered in 1955 and approved for medical use in the United States in 1978. It is on the World Health Organizations List of Essential Medicines. It is produced by fermentation of certain types of the bacterium Streptomyces. Uses
Medical
Natamycin is used to treat fungal infections, including Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium. It is applied topically as a cream, in eye drops, or (for oral infections) in a lozenge. Natamycin shows negligible absorption into the body when administered in these ways. When taken orally, little or none is absorbed from the gastrointestinal tract, making it inappropriate for systemic infections. Natamycin lozenges are also prescribed to treat yeast infections and oral thrush. Food
Natamycin has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. Potential advantages for the usage of natamycin might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives.
A syphilid is any of the cutaneous and mucous membrane lesions characteristic of secondary and tertiary syphilis.It appears about 10 weeks after infection. Patient may present with prodromal symptoms such as fever, acratia, myalgia arthralgia, headache, anorexia. Its eruption pattern is macular, papular,  follicular papules, or pustule, symmetrical, generalized and dense, round or oval in shape, and is red copper in color. See also
Id reactions
List of cutaneous conditions


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