Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. It is recommended that it be taken together with diet and exercise. It may be used with other antidiabetic medication. It is not recommended for use by itself in type 1 diabetes. It is taken by mouth.Common side effects include nausea and heartburn. Serious side effects may include angioedema and low blood sugar. It is generally not recommended during pregnancy but can be used during breastfeeding. It is in the sulfonylureas class of medications and works by increasing the release of insulin from the pancreas.Glibenclamide was discovered in 1969 and approved for medical use in the United States in 1984. It is available as a generic medication. In 2019, it was the 254th most commonly prescribed medication in the United States, with more than 1 million prescriptions. Medical uses
Glibenclamide is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.It is not as good as either metformin or insulin in those who have gestational diabetes. Side effects
Frequently reported side effects include: nausea, heartburn, weight gain, and bloating. The medication is also a major cause of medication-induced hypoglycemia. The risk is greater than with other sulfonylureas.Glibenclamide may be not recommended in those with G6PD deficiency, as it may cause acute hemolysis. Pregnancy and breastfeeding
It is generally not recommended during pregnancy but can be used during breastfeeding.
Image capturing in the eye
Solutions for presbyopia have advanced significantly in recent years due to widened availability of optometry care and over-the-counter vision correction options. Corrective lenses
Corrective lenses provide vision correction over a range as high as +4.0 diopters. People with presbyopia require a convex lens for reading glasses; specialized preparations of convex lenses usually require the services of an optometrist.Contact lenses can also be used to correct the focusing loss that comes along with presbyopia. Multifocal contact lenses can be used to correct vision for both the near and the far. Some people choose contact lenses to correct one eye for near and one eye for far with a method called monovision. Surgery
Refractive surgery has been done to create multifocal corneas. PresbyLASIK, a type of multifocal corneal ablation LASIK procedure may be used to correct presbyopia. Results are, however, more variable and some people have a decrease in visual acuity. Concerns with refractive surgeries for presbyopia include peoples eyes changing with time. Other side effects of multifocal corneal ablation include postoperative glare, halos, ghost images, and monocular diplopia. Image processing in the brain
A number of studies have claimed improvements in near visual acuity by the use of training protocols based on perceptual learning and requiring the detection of briefly presented low-contrast Gabor stimuli; study participants with presbyopia were enabled to read smaller font sizes and to increase their reading speed. Eye drops
Pilocarpine, eye drops that constrict the pupil, has been approved by the FDA for presbyopia. Research on other drugs is in progress.