Wildervanck syndrome or cervico-oculo-acoustic syndrome comprises a triad of:
Duane syndrome
Klippel-Feil anomaly (fused cervical vertebrae)
congenital hearing lossWildervanck syndrome is a developmental disorder that may be characterized by accessory tragi. References


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The mean terminal half-life was similar between pediatric and adult patients and ranged from 15.7 to 22.5 hours. The mean volume of distribution of rasburicase ranged from 110 to 127 mL/kg in pediatric patients and from 75.8 to 138 mL/kg in adult patients, respectively. Minimal accumulation of rasburicase ( < 1.3 fold) was observed between days 1 and 5 of dosing. In adults, age, gender, baseline liver enzymes and creatinine clearance did not impact the pharmacokinetics of rasburicase. A cross-study comparison revealed that after administration of rasburicase at 0.15 or 0.20 mg/kg, the geometric mean values of body-weight normalized clearance were approximately 40% lower in Japanese (n=20) than that in Caucasians (n=22). Society and culture
Economics
Rasburicase is much more expensive than the conventional uric acid lowering treatment for tophaceous gout. References
External links
"Rasburicase". Drug Information Portal. U.S. National Library of Medicine.