Homeless Sam & Sally, a 2020 dark comedy film and a television series with the same name released in 2019, is about a story regarding a mother named Sally Silver and her mentally ill son Sam Silver who comes up with ways to live normal lives while being homeless in Koreatown, Los Angeles. Dark Days, 2000, 81 minutes, documentary by Marc Singer, who followed the lives of people living in the Freedom Tunnel, an Amtrak tunnel in New York City. Homeless to Harvard: The Liz Murray Story, 2003 film about a homeless girl, Liz Murray, who works her way up to admission to Harvard University. 66 Months, a 2011 British documentary film about a homeless man who makes it on his own for 6 years without any government programs helping him. The Pursuit of Happyness, a 2006 biographical film where a father and son struggle to get a job and end up homeless after an eviction and later a tax garnishment. After several weeks living from place to place in 1981 San Francisco, he lands a permanent position in a brokerage firm after successfully completing an unpaid internship. Same Kind of Different as Me, 2017 American film about a successful art dealer, his wife and an initially violent member of a homeless shelter community. It is based on the 2006 book of the same name. Curly Sue, a 1991 comedy drama film that focuses on a homeless con artist and his friend who gets lucky with a roof over their heads by tricking a wealthy attorney.
Generalized epilepsy with febrile seizures plus (GEFS+) is a syndromic autosomal dominant disorder where affected individuals can exhibit numerous epilepsy phenotypes. GEFS+ can persist beyond early childhood (i.e., 6 years of age). GEFS+ is also now believed to encompass three other epilepsy disorders: severe myoclonic epilepsy of infancy (SMEI), which is also known as Dravets syndrome, borderline SMEI (SMEB), and intractable  epilepsy of childhood (IEC). There are at least six types of GEFS+, delineated by their causative gene. Known causative gene mutations are in the sodium channel α subunit genes SCN1A, an associated β subunit SCN1B, and in a GABAA receptor γ subunit gene, in GABRG2 and there is another gene related with calcium channel the PCDH19 which is also known as Epilepsy Female with Mental Retardation. Penetrance for this disorder is estimated at 60%. Signs and symptoms
Individuals with GEFS+ present with a range of epilepsy phenotypes. These include febrile seizures that end by age 6 (FS), such seizures extending beyond age 6 that may include afebrile tonic-clonic, myoclonic, absence, atonic seizures and myoclonic-astatic epilepsy. Individuals may also present with SMEI, characterized by generally tonic-clonic seizures, impaired psychomotor development, myoclonic seizures, ataxia, and poor response to many anticonvulsants. Pathophysiology
Type 1
GEFS+ type 1 is a subtype of GEFS+ in which there are mutations in SCN1B, a gene encoding a sodium channel β subunit. The β subunit is required for proper channel inactivation. There are two known mutations in SCN1B that lead to GEFS+ (Figure 1). The first and best characterized of these mutations is C121W.