A small assessment of sustained release of 0.4 mg belladonna alkaloids and ~60 mg phenobarbital (1 grain) was performed in patients with functional GI disorders (i.e., gastric hyperacidity, dyspepsia, pyrosis, gas pains and epigastric distress. Overall, 23 of 25 patients reported complete or significant relief of symptoms. Hock also examined the effect of 0.25 mg belladonna alkaloids and 50 mg phenobarbital sustained release formulation in 82 clinical practice patients with various gastrointestinal disturbances including “functional distress” over 27 months. Of the 82 total patients, 33 patients reported a 50-75% and 20 reported a 75-100% improvement. There were specific reports of improvements in pain and bowel habits in over half of the patients. One of the earliest randomized double-blind clinical trials of belladonna alkaloids + phenobarbital was in 1959 by Lichstein et al. The study involved 75 patients with unstable bowel (whose symptoms are typical or similar to a current diagnosis of IBS) to investigate the combination therapy of an anticholinergic with the addition of phenobarbital against placebo over 15 months. Of these patients, 20 were treated with placebo, 43 were treated with 50 mg phenobarbital in combination with 0.25 mg Belladonna alkaloids, and 12 received both therapies (patients who lacked a response were switched therapy). Of those receiving the belladonna alkaloids / phenobarbital only, 75.6% reported a mean improvement (2+ or better) in all categories. Among the placebo patients only, only 29.8% reported mean improvement in symptoms.
Out may refer to:

Arts, entertainment, and media
Films
Out (1957 film), a documentary short about the Hungarian Revolution of 1956
Out (1982 film), an American film directed by Eli Hollander
Out (2002 film), a Japanese film based on the novel by Natsuo Kirino and directed by Hideyuki Hirayama
Out (2013 film), a Canadian short comedy film directed by Jeremy LaLonde
Out (2017 film), a Slovak film directed by György Kristóf
Out (2020 film), an American animated film produced by Pixar

Music
Out (jazz) or outside, an approach to jazz improvisation
OUT, a band produced by Adam Walton
OUT, a 1994 album by Nav Katze
Out (In Essence), a 1991 album by Fluke

Television
Out (miniseries), a 1978 British television crime drama starring Tom Bell
"Out" (Dark Angel), a television episode

Other uses in arts, entertainment, and media
Out (magazine), an LGBT fashion, entertainment, and lifestyle magazine
Out (novel), a 1997 novel by Natsuo Kirino
OUTeverywhere, a community website for LGBT people around the world

Sports and recreation
Out (baseball), a play which retires the batter or a base runner
Out (cricket), the loss of a wicket by a batsman; also known as "dismissal"
Out (poker), an unseen card which is expected to win a hand, if drawn
Out (route), a pattern run by a receiver in American football

Sexuality
Coming out, publicly revealing ones own LGBT status
Outing, publicly revealing someone elses LGBT status

Mathematics
Out(Fn), the outer automorphism group of a free group on n generators
Outer automorphism group, a quotient Out(G) of the automorphism group

Transport
Outwood railway station, West Yorkshire, National Rail station code

Other uses
Out, a procedure word in voice radio communication

See also
Outing (disambiguation)
Outside (disambiguation)
All pages with titles containing Out
All pages with titles beginning with Out