Market
Vaniqa, granted marketing approval by the US FDA, as well as by the European Commission among others, is currently the only topical prescription treatment that slows the growth of facial hair. Besides being a non-mechanical and non-cosmetic treatment, it is the only non-hormonal and non-systemic prescription option available for women with facial hirsutism. Vaniqa is marketed by Almirall in Europe, SkinMedica in the US, Triton in Canada, Medison in Israel, and Menarini in Australia.Ornidyl, the injectable form of eflornithine hydrochloride, is licensed by Sanofi-Aventis, but is currently discontinued in the US. In other animals
Eflornithine is effective in mice. Bacchi et al. 1980 found the drug to be curative in T. b. brucei infection of mouse and it is generally without toxicity. Klug et al. 2016 are of the opinion that this demonstrates good promise for oral treatment. However although Jansson et al. 2008 also effectively treated mice with it they found the pharmacokinetics of oral administration in rats very negative. Brun et al. 2010 are of the opinion that Janssons results have killed the prospects for oral treatment. References
External links
History of Drug Development for African Sleeping Sickness
Frotteurism is a paraphilic interest in rubbing, usually ones pelvic area or erect penis, against a non-consenting person for sexual pleasure. It may involve touching any part of the body, including the genital area. A person who practices frotteuristic acts is known as a frotteur. Toucherism is sexual arousal based on grabbing or rubbing ones hands against an unexpecting (and non-consenting) person. It usually involves touching breasts, buttocks or genital areas, often while quickly walking across the victims path. Some psychologists consider toucherism a manifestation of frotteurism, while others distinguish the two. In clinical medicine, treatment of frotteuristic disorder involves cognitive behavioral therapy coupled with the administration of an SSRI. Etymology and history
Frotteuristic acts were probably first interpreted as signs of a psychological disorder by French psychiatrist Valentin Magnan, who described three acts of "frottage" in an 1890 study. "Frottage" derives from the French verb frotter, meaning "to rub". Frotteur is a French noun literally meaning "one who rubs". It was popularized by German sexologist Richard von Krafft-Ebing in his book Psychopathia Sexualis, borrowing from Magnans French terminology. Clifford Allen later coined frotteurism in his 1969 textbook of sexual disorders.The Diagnostic and Statistical Manual of Mental Disorders called this sexual disorder by the name frottage until the third edition (DSM III-R), but changed to frotteurism in the fourth edition, and now uses frotteuristic disorder in the fifth edition. Nevertheless, the term frottage still remains in some law codes where it is synonymous with the term frotteurism.