It is also used in pregnancy as a second choice for treatment of hyperemesis gravidarum (severe nausea and vomiting of pregnancy).It is also used preventatively by some EMS providers when transporting people who are conscious and spinally immobilized. Migraine
In migraine headaches, metoclopramide may be used in combination with paracetamol (acetaminophen) or in combination with aspirin. Gastroparesis
Evidence also supports its use for gastroparesis, a condition that causes the stomach to empty poorly, and as of 2010 it was the only drug approved by the FDA for that condition.It is also used in gastroesophageal reflux disease. Lactation
While metoclopramide is used to try to increase breast milk production, evidence for its effectiveness for this is poor. Its safety for this use is also unclear. Procedures
Intravenous metoclopramide is used in small-bowel follow-through, small-bowel enema, and radionuclide gastric-emptying studies to reduce the time taken for barium to go through the intestines, thus reducing the total time needed for the procedures. Metoclopramide also prevents vomiting after oral ingestion of barium. Contraindications
Metoclopramide is contraindicated in pheochromocytoma. It should be used with caution in Parkinsons disease since, as a dopamine antagonist, it may worsen symptoms. Long-term use should be avoided in people with clinical depression, as it may worsen ones mental state.
The Yash Gandhi Foundation is a US non-profit organization which funds research for I-Cell disease

References
External links

mucolipidoses at NINDS — article derived from detail sheet available here
I cell disease at NIHs Office of Rare Diseases
GeneReview/NIH/UW entry on Mucolipidosis II