History of fatherhood
Many male animals do not participate in the rearing of their young. The development of human men as creatures which are involved in their offsprings upbringing took place during the stone age.In medieval and most of modern European history, caring for children was predominantly the domain of mothers, whereas fathers in many societies provide for the family as a whole. Since the 1950s, social scientists and feminists have increasingly challenged gender roles in Western countries, including that of the male breadwinner. Policies are increasingly targeting fatherhood as a tool of changing gender relations. Research from various societies suggest that since the middle of the 20th century fathers have become increasingly involved in the care of their children. Patricide
In early human history there have been notable instances of patricide. For example:

Tukulti-Ninurta I (r. 1243–1207 B.C.E. ), Assyrian king, was killed by his own son after sacking Babylon. Sennacherib (r. 704–681 B.C.E. ), Assyrian king, was killed by two of his sons for his desecration of Babylon. King Kassapa I (473 to 495 CE) creator of the Sigiriya citadel of ancient Sri Lanka killed his father king Dhatusena for the throne. Emperor Yang of Sui in Chinese history allegedly killed his father, Emperor Wen of Sui. Beatrice Cenci, Italian noblewoman who, according to legend, killed her father after he imprisoned and raped her. She was condemned and beheaded for the crime along with her brother and her stepmother in 1599.
Lung toxicity
Temsirolimus is associated with lung toxicity, and the risk of developing this complication may be increased among subjects with abnormal pre-treatment pulmonary functions or history of lung disease. The risk of interstitial lung disease is increased with temsirolimus doses greater than 25 mg, symptoms of which may include dry cough, fever, eosinophilia, chest pain, and dyspnea on exertion. Toxicity usually occurred early (within days to weeks) or late (months to years) after treatment. Dosing
Although infusion reactions can occur while temsirolimus is being administered, most hypersensitivity reactions occurring on the same day as temsirolimus administration were not severe. Antihistamine pretreatment (e.g. 25–50 mg diphenhydramine, 30 minutes prior to administration) is recommended to minimize the risk of an allergic reaction. See also
Discovery and development of mTOR inhibitors

References
External links
"Temsirolimus". Drug Information Portal. U.S. National Library of Medicine.