It was developed by NeXstar Pharmaceuticals (acquired by Gilead Sciences in 1999). It was approved by the FDA in 1997. It is marketed by Gilead in Europe and licensed to Astellas Pharma (formerly Fujisawa Pharmaceuticals) for marketing in the US, and Sumitomo Pharmaceuticals in Japan. Lipid complex formulations
A number of lipid complex preparations are also available. Abelcet was approved by the FDA in 1995. It consists of amphotericin B and two lipids in a 1:1 ratio that form large ribbon-like structures. Amphotec is a complex of amphotericin and sodium cholesteryl sulfate in a 1:1 ratio. Two molecules of each form a tetramer that aggregate into spiral arms on a disk-like complex. It was approved by the FDA in 1996. By mouth
An oral preparation exists but is not widely available. The amphipathic nature of amphotericin along with its low solubility and permeability has posed major hurdles for oral administration given its low bioavailability. In the past it had been used for fungal infections of the surface of the GI tract such as thrush, but has been replaced by other antifungals such as nystatin and fluconazole.However, recently novel nanoparticulate drug delivery systems such as AmbiOnp, nanosuspensions, lipid-based drug delivery systems including cochleates, self-emulsifying drug delivery systems, solid lipid nanoparticles and polymeric nanoparticles—such as Amphotericin B in pegylated polylactide coglycolide copolymer nanoparticles—have demonstrated potential for oral formulation of amphotericin B. Side effects
Amphotericin B is well known for its severe and potentially lethal side effects.
A synovial bursa (plural bursae or bursas) is a small fluid-filled sac lined by synovial membrane with an inner capillary layer of viscous synovial fluid (similar in consistency to that of a raw egg white). It provides a cushion between bones and tendons and/or muscles around a joint. This helps to reduce friction between the bones and allows free movement. Bursae are found around most major joints of the body. Structure
There are four types of bursa: adventitious, subcutaneous, synovial, and sub-muscular. Among these, only adventitious is non-native. When any surface of the body is subjected to repeated stress, an adventitious bursa develops under it. Examples are Students elbow and bunion. Clinical significance
Infection or irritation of a bursa leads to bursitis (inflammation of a bursa). The general term for disease of bursae is "bursopathy." History
Etymology
Bursa is Medieval Latin for "purse", so named for the resemblance of an anatomical bursa to a purse. Bursae or bursas is its plural form. See also
Bursa of Fabricius (a lymphatic organ in birds)
Bursectomy
Knee bursae
Shoulder joint#Bursae

External links

Hirji, Zameer; Hunjun, Jaspal S; Choudur, Hema N (2 May 2011). "Imaging of the Bursae". Journal of Clinical Imaging Science. 1: 22. doi:10.4103/2156-7514.80374. PMC 3177464. PMID 21966619. Bursa
Diagram of elbow with olecranon bursa