This occurs through inappropriate activation of inactive enzyme precursors called zymogens (or proenzymes) inside the pancreas, most notably trypsinogen. Normally, trypsinogen is converted to its active form (trypsin) in the first part of the small intestine (duodenum), where the enzyme assists in the digestion of proteins. During an episode of acute pancreatitis, trypsinogen comes into contact with lysosomal enzymes (specifically cathepsin), which activate trypsinogen to trypsin. The active form trypsin then leads to further activation of other molecules of trypsinogen. The activation of these digestive enzymes lead to inflammation, edema, vascular injury, and even cellular death. The death of pancreatic cells occurs via two main mechanisms: necrosis, which is less organized and more damaging, or apoptosis, which is more controlled. The balance between these two mechanisms of cellular death is mediated by caspases which regulate apoptosis and have important anti-necrosis functions during pancreatitis: preventing trypsinogen activation, preventing ATP depletion through inhibiting polyADP-ribose polymerase, and by inhibiting the inhibitors of apoptosis (IAPs). If, however, the caspases are depleted due to either chronic ethanol exposure or through a severe insult then necrosis can predominate. Pathophysiology
The two types of acute pancreatitis are mild and severe, which are defined based on whether the predominant response to cell injury is inflammation (mild) or necrosis (severe). In mild pancreatitis, there is inflammation and edema of the pancreas. In severe pancreatitis, there is necrosis of the pancreas, and nearby organs may become injured.
The use of the word accident to describe car wrecks was promoted by the US National Automobile Chamber of Commerce in the middle of the 20th century, as a way to make vehicle-related deaths and injuries seem like an unavoidable matter of fate, rather than a problem that could be addressed. The automobile industry accomplished this by writing customized articles as a free service for newspapers that used the industrys preferred language. Since 1994, the US National Highway Traffic Safety Administration has asked media and the public to not use the word accident to describe vehicle collisions. Aviation
Bicycles
Sailing ships
Traffic collisions
Train wrecks
Trams

Domino effect accidents
In the process industry, a primary accident may propagate to nearby units, resulting in a chain of accidents, which is called domino effect accident. Common causes
Poisons, vehicle collisions and falls are the most common causes of fatal injuries. According to a 2005 survey of injuries sustained at home, which used data from the National Vital Statistics System of the United States National Center for Health Statistics, falls, poisoning, and fire/burn injuries are the most common causes of death.The United States also collects statistically valid injury data (sampled from 100 hospitals) through the National Electronic Injury Surveillance System administered by the Consumer Product Safety Commission. This program was revised in 2000 to include all injuries rather than just injuries involving products. Data on emergency department visits is also collected through the National Health Interview Survey. In The U.S. the Bureau of Labor Statistics has available on their website extensive statistics on workplace accidents.