cobalt, or additives and preservatives in foods, including benzoates, benzoic acid, cinnamaldehyde, metabisulfates, butylated hydroxyanisole, dodecyl gallate, tartrazine, or menthol, Examples of foods which may contain these substances include margarine,  cinnamon, eggs, chocolate or peppermint oil.Some suggest that infection with atypical mycobacteria could be involved, (paratuberculosis), and that OFG is a reaction to mycobacterial stress protein mSP65 acting as an antigen.In response to an antigen, a chronic, submucosal, T cell mediated inflammatory response occurs, which involves cytokines (e.g. tumor necrosis factor alpha), protease-activated receptors, matrix metalloproteinases and cyclooxygenases. The granulomas in OFG form in the lamina propria, and may form adjacent to or within lymphatic vessels. This is thought to cause obstruction of lymphatic drainage and lymphedema which is manifest as swelling clinically.There may be a genetic predisposition to the condition. People who develop OFG often have a history of atopy, such as childhood asthma or eczema. Diagnosis
The diagnosis is usually made by tissue biopsy, however this cannot reliably distinguish between the granulomas of OFG and those of Crohn disease or sarcoidosis. Other causes of granulomatous inflammation are ruled out, such as sarcoidosis,
Crohn disease, allergic or foreign body reactions and mycobacterial infections. Classification
OFG could be classified as a type of cheilitis (lip inflammation), hence the alternative names for the condition using the word cheilitis, and a granulomatous condition. Treatment
Anti-tumour necrosis factor α drugs (e.g. infliximab) Dietary restriction of a particular suspected or proven antigen may be involved in the management of OFG, such as cinnamon or benzoate-free diets.
Lipoblastoma is a type of rare, subcutaneous, benign, fatty tumor, found in infants, and children, more common in males with tendency of local recurrence. Local recurrence can happen in up to 80% of incompletely resected tumours. Therefore, complete surgical resection is required to prevent recurrence. It arises from embyronic white fat that is rapidly enlarging. Most common locations are at the trunk and extremities.Types include:
Benign lipoblastomatosis, a tumor, also known as an embryonic lipoma, which usually occurs in children under three years old. This is the tumor of brown fat cells. Myxoid lipoblastoma, a cutaneous condition characterized by excess mucin

Specimen
Macroscopic
Grossly, it has a pale yellow, myxoid cut surface with small cystic foci. Microscopic
It has lobules consists of immature adipose tissue separated by fibrous septa and lipoblasts at different stages of maturation, without atypia or mitosis. Plexiform capillary network and mature adipose tissue are seen at the central part of the lobule. See also
Lipoblast
Lipoma


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