Collins bodies form in cortical and subcortical neurons where they disrupt the cells normal functioning and ultimately lead to cell death. Progressive dementia results from this gradual loss of nerve cells in certain parts of the brain. Researchers believe that a buildup of related, potentially toxic substances in nerve cells may also contribute to the signs and symptoms of this condition.This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In many cases, an affected person has a parent with the condition. References

National Library of Medicine. Genetics Home Reference - Familial encephalopathy with neuroserpin inclusion bodies


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Dyschromatosis universalis hereditaria is a rare genodermatosis characterized by reticulate hyper- and hypo- pigmentated macules in a generalized distribution. : 856 Both autosomal dominant and recessive inheritance have been reported with the disorder.It has been associated with mutations in genes SASH1 and ABCB6. References
External links

Dyschromatosis universalis hereditaria: Two cases, Dermatology Online Journal.