Attempts have been made to see whether it is possible to risk stratify newborns in order to decide if a newborn can be safely monitored at home without treatment despite having a fever. One such attempt is the Rochester criteria. Signs and symptoms
The signs of sepsis are non-specific and include:
Body temperature changes
Breathing problems
Diarrhea
Low blood sugar (hypoglycemia)
Reduced movements
Reduced sucking
Seizures
Bradycardia
Swollen belly area
Vomiting
Yellow skin and whites of the eyes (jaundice). hemorrhagic rashA heart rate above 160 can also be an indicator of sepsis, this tachycardia can present up to 24 hours before the onset of other signs. Risk factors
A study performed at Strong Memorial Hospital in Rochester, New York, showed that infants ≤ 60 days old meeting the following criteria were at low-risk for having a serious bacterial illness:
generally well-appearing
previously healthy
full term (at ≥37 weeks gestation)
no antibiotics perinatally
no unexplained hyperbilirubinemia that required treatment
no antibiotics since discharge
no hospitalizations
no chronic illness
discharged at the same time or before the mother
no evidence of skin, soft tissue, bone, joint, or ear infection
White blood cells (WBCs) count 5,000-15,000/mm3
absolute band count ≤ 1,500/mm3
urine WBC count ≤ 10 per high power field (hpf)
stool WBC count ≤ 5 per high power field (hpf) only in infants with diarrheaThose meeting these criteria likely do not require a lumbar puncture, and are felt to be safe for discharge home without antibiotic treatment, or with a single dose of intramuscular antibiotics, but will still require close outpatient follow-up. One risk for Group B streptococcal infection (GBS) is preterm rupture of membranes.
There are two forms:

A few non-hereditary diseases formerly categorized as olivopontocerebellar atrophy have been reclassified as forms of multiple system atrophy as well as to four hereditary types, that have been currently reclassified as four different forms of spinocerebellar ataxia:

Diagnosis
A diagnosis of olivopontocerebellar atrophy (OPCA) may be based on a thorough medical exam; the presence of signs and symptoms; imaging studies; various laboratory tests; and an evaluation of the family history.MRI of the brain may show characteristics of OPCA, such as specific changes in the size of affected parts of the brain. This is more likely as the disease progresses; it is possible to have OPCA and have a normal brain MRI (especially within the first year of symptom onset).Hereditary OPCA may be suspected based on having a family history, and may be diagnosed by genetic testing (when available) for the condition suspected or known to be present in the family. Sporadic OPCA may be diagnosed if hereditary forms of OPCA, and other conditions associated with OPCA, have been ruled out. Treatment
Physiotherapy intervention aims to improve balance and gait of OPCA patients, by stimulating neuroplastic changes in the atrophied neural structure. A challenge-oriented treatment program has previously been shown to be beneficial for individuals with ataxia from OPCA. The treatment program was composed of repetitive training with task challenges (e.g. obstacle course) and/or novel motor skills acquisition over a 12-week period under the supervision of a physiotherapist.