Those with the Setleis syndrome may be missing eyelashes on both the upper and lower lids or may have multiple rows of lashes on the upper lids but none on the lower lids.A possible association with intra abdominal cancer has been reported but to date this has not been confirmed in other studies. Genetics
Type II appears to be due to mutations in the transcription factor TWIST2 on chromosome 2.Type IV is due to mutations in the Cyp26c1 gene. Pathology
Under the temporal lesions the skeletal muscle is almost in direct continuity with the epidermis. Diagnosis
Classification
There are at least four types of FFDD:
Type I: autosomal dominant FFDD
Type II: autosomal recessive FFDD
Type III: FFDD with other facial features : Setleis syndrome
Type IV: facial lesions resembling aplasia cutis in a preauricular distribution along the line of fusion of the maxillary and mandibular prominences. Autosomal recessive. Treatment
History
The syndrome was first described by Brauer in 1929 in a large five generation family (38 members). The affected progenitor (Johann Jokeb Van Bargen) was a man who had migrated to Germany from Holland in the 16th century. As many as 155 family members were thought to have been affected. References


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Solitary cutaneous leiomyoma typically presents as a deeply circumscribed, freely movable, rounded nodule ranging from 2 to 15 mm in diameter, with overlying skin that may have a reddish or violaceous tint. : 627

See also
Multiple cutaneous leiomyoma
Leiomyoma
Skin lesion


== References ==