Genetics
Many genes play a role in inflammation and collagen production, therefore inherited genes may play a role in predisposing a person to PROM. Diagnosis
To confirm if a woman has experienced PROM, a clinician must prove that the fluid leaking from the vagina is amniotic fluid, and that labor has not yet started. To do this, a careful medical history is taken, a gynecological exam is conducted using a sterile speculum, and an ultrasound of the uterus is performed. History: a person with PROM typically recalls a sudden "gush" of fluid loss from the vagina, or steady loss of small amounts of fluid. Sterile speculum exam: a clinician will insert a sterile speculum into the vagina in order to see inside and perform the following evaluations. Digital cervical exams, in which gloved fingers are inserted into the vagina to measure the cervix, are avoided until the women is in active labor to reduce the risk of infection.Pooling test: Pooling is when a collection of amniotic fluid can be seen in the back of the vagina (vaginal fornix). Sometimes leakage of fluid from the cervical opening can be seen when the person coughs or performs a valsalva maneuver. Nitrazine test: A sterile cotton swab is used to collect fluid from the vagina and place it on nitrazine (phenaphthazine) paper. Amniotic fluid is mildly basic (pH 7.1–7.3) compared to normal vaginal secretions which are acidic (pH 4.5–6). Basic fluid, like amniotic fluid, will turn the nitrazine paper from orange to dark blue.
Fibrocystic breast changes
Also called:  fibrocystic breast disease, chronic cystic mastitis, diffuse cystic mastopathy, mammary dysplasia

Infections and inflammations
These may be caused among others by trauma, secretory stasis/milk engorgement, hormonal stimulation, infections or autoimmune reactions. Repeated occurrence unrelated to lactation requires endocrinological examination. bacterial mastitis
mastitis from milk engorgement or secretory stasis
mastitis
chronic subareolar abscess
tuberculosis of the breast
syphilis of the breast
retromammary abscess
actinomycosis of the breast
duct ectasia syndrome
breast engorgement

Other breast conditions
Mondors disease
Pagets disease of the breast
nipple discharge, galactorrhea
breast cyst
mastalgia
galactocoele

See also
Mammary gland

References
Further reading
Irshad, A.; Ackerman, S. J.; Pope, T. L.; Moses, C. K.; Rumboldt, T.; Panzegrau, B. (2008). "Rare Breast Lesions: Correlation of Imaging and Histologic Features with WHO Classification1". Radiographics. 28 (5): 1399–1414. doi:10.1148/rg.285075743. PMID 18794315. == External links ==