Fostamatinib, sold under the brand names Tavalisse and Tavlesse, is a tyrosine kinase inhibitor medication for the treatment of chronic immune thrombocytopenia (ITP). The drug is administered by mouth.Fostamatinib blocks the activity of the enzyme spleen tyrosine kinase (SYK). This enzyme is involved in stimulating parts of the immune system. By blocking SYKs activity, fostamatinib reduces the immune systems destruction of platelets, so allowing the platelet count to rise, which reduces the likelihood of excessive bleeding.The most commonly reported side effects are diarrhea, high blood pressure, nausea, respiratory infection, dizziness, increased liver enzymes, rash, abdominal pain, fatigue, chest pain and decreased white blood cell count.The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. Medical uses
Fostamatinib is a drug used to treat adults with low platelet count due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough. Chronic immune thrombocytopenia is an autoimmune bleeding disorder where the blood doesnt clot as it should because of a low platelet count. Pharmacology
Mechanism of action
The tablets are formulated as fostamatinib disodium hexahydrate, a disodium hexahydrate salt, and is a prodrug of the active compound tamatinib (R-406), which is an inhibitor of the enzyme spleen tyrosine kinase (Syk), hence it is an syk inhibitor. Syk is a protein tyrosine kinase associated with various inflammatory cells, including macrophages, which are presumed to be the cells responsible for ITP platelet clearance.
Incidence
Seabathers eruption is common throughout the range of Linuche unguiculata in the Caribbean, Florida, Mexico, and Gulf States. Cases were first identified in Brazil in 2001. The closely related Linuche aquila, found anywhere between Malaysia, the Philippines and the east coast of Africa, is also known to cause the condition.Swimmers in Queensland, Australia, have reported seabathers eruption during the summer months of the year. Swimmers at the east-coast beaches of Auckland and the rest of the Hauraki Gulf in New Zealand can develop seabathers eruption, typically during summer. References


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