In particular, cases of bilateral Wilms tumor, as well as cases of Wilms tumor derived from certain genetic syndromes such as Denys-Drash syndrome, are strongly associated with nephrogenic rests. Most nephroblastomas are on one side of the body only and are found on both sides in less than 5% of cases, although people with Denys-Drash syndrome mostly have bilateral or multiple tumors. They tend to be encapsulated and vascularized tumors that do not cross the midline of the abdomen. In cases of metastasis it is usually to the lung. A rupture of Wilms tumor puts the patient at risk of bleeding and peritoneal dissemination of the tumor. In such cases, surgical intervention by a surgeon who is experienced in the removal of such a fragile tumor is imperative.Pathologically, a triphasic nephroblastoma comprises three elements:
blastema
mesenchyme (stroma)
epitheliumWilms tumor is a malignant tumor containing metanephric blastema, stromal and epithelial derivatives. Characteristic is the presence of abortive tubules and glomeruli surrounded by a spindled cell stroma. The stroma may include striated muscle, cartilage, bone, fat tissue, and fibrous tissue.
By employing the antibiotic actinomycin D in addition to surgery and radiation therapy, they boosted cure rates from 40 to 89 percent.The use of computed tomography scan for the diagnosis of Wilms tumor began in the early 1970s, thanks to the intuition of Dr. Mario Costici, an Italian physician. He discovered that in the direct radiograms and in the urographic images, you can identify determining elements for a differential diagnosis with the Wilms tumor. This possibility was a premise for starting a treatment. See also
Hemihypertrophy
National Wilms Tumor Study Group (NWTS)
Perlman syndrome
Virtual Karyotype for 1p and 16q LOH

References
External links

Wilms tumor at Curlie
GeneReviews/NCBI/NIH/UW entry on Wilms Tumor Overview
Information from National Cancer Institute
Cancer.Net Wilms Tumor – Childhood