In 1999, topiramate trials showed that topiramate decreased seizure occurrence by more than 50%.Felbamate is the treatment of last resort in the event that everything else fails, and was found to be superior to placebo in controlling treatment resistant partial seizures and atonic seizures. However, it has been known to cause aplastic anemia and liver toxicity. First-line drugs
valproate (valproic acid, sodium valproate and valproate semisodium)

Second-line drugs
lamotrigineThird-line drugs

rufinamide
topiramateTreatment of last resort

felbamate

Adjuvant drugs
Are the following:
benzodiazepines, specifically clonazepam, nitrazepam, and clobazam
zonisamide
cannabidiol

Surgery
In the past, LGS patients were not eligible for surgery, as the medical community thought it to involve the whole brain as a generalized epilepsy in all cases. Since 2010, this assumption has been challenged. Two studies on LGS patients series who underwent curative surgery in Korea and China, showed very good results, up to seizure freedom for 80% of these patients below 5 years old, and 40% above 5 years old. Like all epilepsy curative surgeries, seizures may recur in the years following surgery, but surgery allows the child to have better brain development during the seizure free period.There are several procedures that have shown efficacy:
vagus nerve stimulation, which involves implantation of battery-operated generator of intermittent electrical stimuli to an electrode wrapped around left vagus nerve. Some studies have been shown it to have greater than 50% reduction in seizures reported in more than half of patients. corpus callosotomy, which has shown to be effective with atonic seizures.
Neonatal hypoglycaemia can be a stand-alone condition or a clinical manifestation of other conditions. Signs and symptoms
The way in which neonatal hypoglycemia symptoms may be presented is vague or hard to tell apart from other conditions. The symptoms can be confused with:

hypocalcemia
Sepsis
CNS disorders
Cardiorespiratory problemsNeonatal hypoglycemia can also show no symptoms in some newborns or may be life-threatening.Some observed symptoms are (these symptoms may be transient but reoccurring):

Jitteriness
hypothermia 
irritability 
pallor 
tremors
twitching
weak or high pitched cry
lethargy
hypotonia
generalized seizures
coma
cyanosis
apnea
rapid and irregular respirations
diaphoresis
eye rolling
refusal to feed
hunger

Causes
Risk Factors
Mother
Risk factors in the mother that increased the risk of developing hypoglycemia shortly after birth include:

Type 1 diabetes
Gestational diabetes mellitus (Transient)
Intrapartum glucose administration (Transient)
Gestational hypertension
Preeclampsia
Terbutaline administration (Transient)
Intrauterine growth restriction (Transient)
Perinatal stress or asphyxia (Transient)

Baby
Babies which have an increased risk of developing hypoglycemia shortly after birth are:

hypothermia (Transient)
polycythemia (Transient)
hyperinsulinism (Recurrent)
IEMs (Recurrent)
Beckwith-Wiedmann syndrome (Recurrent)
nesidioblastosis (Recurrent)
Rh isoimmunization (Recurrent)
Certain endocrine disorders (Recurrent)
fetal hydrops
Prematurity (Transient)
congenital malformations
small for gestational age (Transient)
Large for gestational age (Transient)

Hyperinsulinism
The most common cause on neonatal hypoglycemia is hyperinsulinism. Hyperinsulinism is also called persistent hyperinsulemic hypoglycemia of infancy (PHHI). This is seen very frequently to the neonates born from mothers with diabetes. Congenital hyperinsulinism is correlated with the abnormality of beta-cell regulation within the pancreas. Isolated islet adenoma, which is a focal disease, is often the cause of congenital hyperinsulism. Drug-induced hyperinsulisim is correlated with the administration insulin or use of hypoglycemic medication. In critical cases, a drug called Diazoxide is availed to stop any secretion of insulin. Limited glycogen stores
Limited glycogen storage occurs in premature newborns or newborns that had intrauterine growth retardation.