Plerixafor (INN and USAN, trade name Mozobil) is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are then extracted from the blood and transplanted back to the patient. The drug was developed by AnorMED, which was subsequently bought by Genzyme. Medical uses
Peripheral blood stem cell mobilization, which is important as a source of hematopoietic stem cells for transplantation, is generally performed using granulocyte colony-stimulating factor (G-CSF), but is ineffective in around 15 to 20% of patients. Combination of G-CSF with plerixafor increases the percentage of persons that respond to the therapy and produce enough stem cells for transplantation. The drug is approved for patients with lymphoma and multiple myeloma.Phase 2 clinical trials started in 2021 exploring the combination of plerixafor and MGTA-145, a CXCL2 ligand. Contraindications
Pregnancy and lactation
Studies in pregnant animals have shown teratogenic effects. Plerixafor is therefore contraindicated in pregnant women except in critical cases. Fertile women are required to use contraception. It is not known whether the drug is secreted into the breast milk. Breast feeding should be discontinued during therapy. Adverse effects
Nausea, diarrhea and local reactions were observed in over 10% of patients. Other problems with digestion and general symptoms like dizziness, headache, and muscular pain are also relatively common; they were found in more than 1% of patients. Allergies occur in less than 1% of cases.
This strategy was used in Ireland, in Kenya, in Algeria and in Cyprus during their independence struggles.Stated motives for the September 11 attacks included inspiring more fighters to join the cause of repelling the United States from Muslim countries with a successful high-profile attack. The attacks prompted some criticism from domestic and international observers regarding perceived injustices in U.S. foreign policy that provoked the attacks, but the larger practical effect was that the United States government declared a War on Terror that resulted in substantial military engagements in several Muslim-majority countries. Various commentators have inferred that al-Qaeda expected a military response, and welcomed it as a provocation that would result in more Muslims fight the United States. Some commentators believe that the resulting anger and suspicion directed toward innocent Muslims living in Western countries and the indignities inflicted upon them by security forces and the general public also contributes to radicalization of new recruits. Despite criticism that the Iraqi government had no involvement with the September 11 attacks, Bush declared the 2003 invasion of Iraq to be part of the War on Terror. The resulting backlash and instability enabled the rise of Islamic State of Iraq and the Levant and the temporary creation of an Islamic caliphate holding territory in Iraq and Syria, until ISIL lost its territory through military defeats. Attacks used to draw international attention to struggles that are otherwise unreported have included the Palestinian airplane hijackings in 1970 and the 1975 Dutch train hostage crisis.