It can be generated by treating potassium hydroxide (or other potassium bases) with hydrochloric acid:

  
    
      
        
          KOH
          +
          HCl
          ⟶
          KCl
          +
          
            H
            
              2
            
            
              
            
          
          O
        
      
    
    {\displaystyle {\ce {KOH + HCl -> KCl + H2O}}}
  This conversion is an acid-base neutralization reaction.
They are implicated in the development of aggressive periodontitis by triggering inflammatory response in periodontal tissue. There are abnormalities associated with phagocytes.Phagocytes are essential in resolving inflammation. The impairment of their phagocytic activity results in persistent inflammation in periodontal tissues. Hyper-responsive macrophage phenotype.Due to the increased responsiveness, the macrophages produce excessive levels of inflammatory mediator and cytokine, such as prostaglandin E2 (PGE2) and interleukin-1β (IL-1B). Their hyperactivity is associated with periodontal tissue destruction and bone loss. Progression of attachment loss and bone loss may be self-arresting.In some patients, the disease may burnout without any cause-related therapy. Caries levels have seen to be lower in cases of aggressive periodontitis.Staging
Cases of aggressive periodontitis have been staged into Stage I, II and III based on the severity of the cases. The staging index was proposed based on clinical features, radiological features and possible risk factors. The proposed index was validated with 10 cases of aggressive periodontitis followed for 10 years. Clinical and radiographic features
Localized aggressive periodontitis
Clinical features
LAP begins around the age of puberty where there is interproximal loss of attachment of the first molar, and or incisors. on at least two permanent teeth (one which is a first molar) and no involvement of more than two teeth other than the first molars and incisors, lack of inflammation and evidence of deep periodontal pocket with advanced bone loss.