for more details

Prognosis
Currently, there are no clinically established laboratory investigations available to predict prognosis or therapeutic response.Tumors in children who develop OMS tend to be more mature, showing favorable histology and absence of n-myc oncogene amplification than similar tumors in children without symptoms of OMS. Involvement of local lymph nodes is common, but these children rarely have distant metastases and their prognosis, in terms of direct morbidity and mortality effects from the tumor, is excellent. The three-year survival rate for children with non-metastatic neuroblastoma and OMS was 100% according to Childrens Cancer Group data (gathered from 675 patients diagnosed between 1980 and 1994); three-year survival in comparable patients with OMS was 77%. Although the symptoms of OMS are typically steroid-responsive and recovery from acute symptoms of OMS can be quite good, children often experience lifelong neurologic sequelae that impair motor, cognitive, language, and behavioral development.Most children will experience a relapsing form of OMS, though a minority will have a monophasic course and may be more likely to recover without residual deficits. Viral infection may play a role in the reactivation of disease in some patients who had previously experienced remission, possibly by expanding the memory B cell population. Studies have generally asserted that 70-80% of children with OMS will have long-term neurologic, cognitive, behavioral, developmental, and academic impairment.
There are no confirmed differences in safety, purity, or clinical efficacy among the various available urinary or recombinant gonadotropin products.”

List of hMG preparations
A number of drug companies have and had marketed hMG preparations that include:
Gynogen HP (Sanzyme (P) Limited)Highly purified urinary FSH and LH in 1:1 ratioHumog (Bharat Serums And Vaccines Ltd)highly purified urinary FSH and LH in 1:1 ratioHumegon (Organon)
Menopur (Ferring Pharmaceuticals), 75 IU FSH and 75 IU LH activity
Merional, Meriofert (IBSA Institut)
Menogon
Metrodin (Serono)highly purified urinary FSHRepronex (Ferring Pharmaceuticals), 75 IU FSH and 75 IU LH
Pergonal (Serono),Pergonal was the major hMG prior to the arrival of recombinant gonadotropins containing 75 IU FSH and 75 IU LH.HMG Massone, 75 IU FSH and 75 IU LH

See also
Gonadotropin preparations


== References ==