U.S. National Library of Medicine.
Dextromethorphan, an N-methyl-D-aspartate receptor antagonist, inhibits glutamatergic transmission in the regions of the brainstem and cerebellum, which are hypothesized to be involved in pseudobulbar symptoms, and acts as a sigma ligand, binding to the sigma-1 receptors that mediate the emotional motor expression. See also
Corticobulbar tract
Bulbar palsy, a similar syndrome caused by the damage of lower motor neurons. Motor neuron disease

References


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