Children should receive a much lesser dose: 20,000–50,000 IU, per kg of body weight per day. However, if somebody is allergic to penicillin, streptomycin and tetracycline can be administered as they have also been observed to provide efficacious results. In case of complications such as endocarditis, a combination therapy with both intravenous penicillin G and streptomycin or gentamicin is necessary. References


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At least three out of five criteria yields sensitivity and specificity of 95 and 91%: 

Age at onset ≥ 50 years
New onset headache with localized tenderness
Temporal artery tenderness or decreased pulsation
Elevated ESR ≥ 50 mm/hour Westergren
Temporal artery biopsy showing vasculitis with mononuclear cell infiltrate or granulomatous inflammation, usually with multinucleated giant cells

Medium vessel vasculitis
These conditions are sometimes considered together with the small vessel vasculitides.Polyarteritis nodosa (PAN). Systemic necrotizing vasculitis and aneurysm formation affecting both medium and small arteries. If only small vessels are affected, it is called microscopic polyangiitis, although it is more associated with granulomatosis with polyangiitis than to classic PAN. At least 3 out of 10 criteria yields sensitivity and specificity of 82 and 87%:

Unexplained weight loss > 4 kg
Livedo reticularis
Testicular pain
Myalgias, weakness
Abdominal pain, diarrhea, and GI bleeding
Mononeuropathy or polyneuropathy
New onset diastolic blood pressure > 90 mmHg
Elevated serum blood urea nitrogen (> 40 mg/dL) or serum creatinine (> 1.5 mg/dL)
Hepatitis B infection
Arteriographic abnormalities
Arterial biopsy showing polymorphonuclear cellsKawasaki disease. Usually in children (age<4), it affects large, medium, and small vessels, prominently the coronary arteries. Associated with a mucocutaneous lymph node syndrome. Diagnosis requires fever lasting five days or more with at least four out of five criteria:

Bilateral conjunctival injection
Injected or fissured lips, injected pharynx, or strawberry tongue
Erythema of palms/soles, edema of hands/feet, periungual desquamation
Polymorphous rash
Cervical lymphadenopathy (at least one node > 1.5 cm)Isolated cerebral vasculitis. Affects medium and small arteries over a diffuse CNS area, without symptomatic extracranial vessel involvement. Patients have CNS symptoms as well as cerebral vasculitis by angiography and leptomeningeal biopsy.