Type 1 (D1) deiodinates T4 to the biologically active T3, as well as the hormonally inactive and possibly inhibitory rT3. Type 2 (D2) converts T4 into T3, and breaks down rT3. D3 produces rT3 from T4, and breaks down T3. The balance of D2 and D3 is important for overall T3/rT3 balance.In NTIS, the concentrations of these deiodinases are altered, although  whether NTIS is the cause or effect of this in peripheral tissues is unclear; in some studies, the alterations in thyroid hormone concentrations occurred before the changes in deiodinase activity. Typically, peripheral D1 and D2 are downregulated, while peripheral D3 is upregulated; this is associated with lower T4 and increased rT3. Hypothalamic-pituitary-thyroid axis downregulation
Thyrotropin releasing hormone (TRH) neurons in the hypothalamus integrate global signals about the bodys energy state. They may be stimulated by signals such as leptin, alpha-MSH, and catecholamines; and inhibited by glucocorticoids, neuropeptide Y, and agouti-related peptide. In critical illness, inflammation increases tanycyte D2 in the paraventricular nucleus (PVN) of the hypothalamus, leading to local tissue hyperthyroidism. There may also be decreased central D3. This causes negative feedback on the HPT axis, and therefore reduced TRH gene expression in the PVN. This is exemplified by the common NTIS phenotype of low TSH even in the face of peripheral hypothyroidism. Cytokines
Illness can cause inflammation, which often involves an increase in cytokines such as TNFa, IL-1, and IL-6. Cytokines are implicated in NTIS. IL-1β has been shown to decrease liver D1, as well as thyroid hormone receptor (THR) levels.
Botryoid odontogenic cyst is a variant of the lateral periodontal cyst. It is more often found in middle-aged and older adults, and the teeth more likely affected are mandibular (lower) canines and premolars. On radiographs, the cyst appears "grape-like". Often patients with this condition are symptomatic. Radiographic features
The botryoid odontogenic cyst is a multi-compartmentalized variant of the lateral periodontal cyst. It is similar to the lateral periodontal cyst in all its features except that its polycystic nature is often evident through its multilocular pattern on radiographs. Histologic features
Histologically also it resembles the lateral periodontal cyst which has a distinctive thin, nonkeratinized epithelium which is 1-5 cell layers thick and resembles the reduced enamel epithelium. Cuboidal or columnar cells may be found composing the lining. Focal thickened plaques of proliferating lining cells often project into the lumen areas which is commonly seen in this cyst. Large number of rests of dental lamina are found in the connective tissue composed of glycogen rich clear cells.reference can be made to the histologic details given by shear and pindborg

References

Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
shafers textbook of oral pathology 5th edition