Researchers suspect it is caused by a pathology of the central nervous system, likely originating in those parts of the brain concerned with motor function—such as the basal ganglia and the GABA (gamma-aminobutyric acid) producing Purkinje neurons. The precise cause of primary dystonia is unknown. In many cases it may involve some genetic predisposition towards the disorder combined with environmental conditions.Secondary dystonia refers to dystonia brought on by some identified cause, such as head injury, drug side effect (e.g. tardive dystonia), or neurological disease (e.g. Wilsons disease, stroke).Meningitis and encephalitis caused by viral, bacterial, and fungal infections of the brain have been associated with dystonia. The main mechanism is inflammation of the blood vessels, causing restriction of blood flow to the basal ganglia. Other mechanisms include direct nerve injury by the organism or a toxin, or autoimmune mechanisms.Environmental and task-related factors are suspected to trigger the development of focal dystonias because they appear disproportionately in individuals who perform high precision hand movements such as musicians, engineers, architects, and artists. Chlorpromazine can also cause dystonia, which can be often misjudged as a seizure.Neuroleptic drugs often cause dystonia, including oculogyric crisis.Malfunction of the sodium-potassium pump may be a factor in some dystonias. The Na+-K+ pump has been shown to control and set the intrinsic activity mode of cerebellar Purkinje neurons. This suggests that the pump might not simply be a homeostatic, "housekeeping" molecule for ionic gradients; but could be a computational element in the cerebellum and the brain.
Cerocorticium molle is a species of crust fungus in the family Meruliaceae. Taxonomy
The fungus was first described by Miles Berkeley and Moses Ashley Curtis in 1868 as Corticium molle. They described the fruit body of the type specimen as resembling "a thin coating of wax poured over the surface". It was transferred to genus Cerocorticium by Walter Jülich in 1975. Habitat and distribution
Cerocorticium molle grows on the dead bark and wood of a variety of angiosperms, and it has occasionally been recorded growing on or under the bark of living trees. It is found in tropical and subtropical regions of Africa, Asia, North America, and South America. == References ==