Note that it is often difficult to differentiate osteomyelitis from a Charcot joint, as they may have similar tagged WBC scan and MRI features (joint destruction, dislocation, edema). Definitive diagnosis may require bone or synovial biopsy. Radiologic findings
First, it is important to recognize that two types of abnormality may be detected. One is termed atrophic, in which there is osteolysis of the distal metatarsals in the forefoot. The more common form of destruction is hypertrophic joint disease, characterized by acute peri-articular fracture and joint dislocation. According to Yochum and Rowe, the "6 Ds" of hypertrophy are:  

Distended joint
Density increase
Debris production
Dislocation
Disorganization
DestructionThe natural history of the joint destruction process has a classification scheme of its own, offered by Eichenholtz decades ago:
Stage 0: Clinically, there is joint edema, but radiographs are negative. Note that a bone scan may be positive before a radiograph is, making it a sensitive but not very specific modality. Stage 1: Osseous fragmentation with joint dislocation seen on radiograph ("acute Charcot"). Stage 2: Decreased local edema, with coalescence of fragments and absorption of fine bone debris. Stage 3: No local edema, with consolidation and remodeling (albeit deformed) of fracture fragments. The foot is now stable. Atrophic features:

"Licked candy stick" appearance, commonly seen at the distal aspect of the metatarsals
Diabetic osteolysis
Bone resorption

Treatment
Once the process is recognized, it should be treated via the VIPs — vascular management, infection management and prevention, and pressure relief. Aggressively pursuing these three strategies will progress the healing trajectory of the wound.
Triamterene (trade name Dyrenium among others) is a potassium-sparing diuretic often used in combination with thiazide diuretics for the treatment of high blood pressure or swelling. The combination with hydrochlorothiazide, is known as hydrochlorothiazide/triamterene. Side effects
Common side effects may include a depletion of sodium, folic acid, and calcium, nausea, vomiting, diarrhea, headache, dizziness, fatigue, and dry mouth. Serious side effects may include heart palpitations, tingling/numbness, fever, chills, sore throat, rash, and back pain. Triamterene can also cause kidney stones through direct crystallization or by seeding calcium oxalate stones. Triamterene is best avoided in patients with chronic kidney disease due to the possibility of hyperkalemia. People using this drug should use salt substitute cautiously.Triamterene may impart a blue fluorescent color to the urine. Caution with certain disease states
Diabetes: Use with caution in people with prediabetes or diabetes mellitus as there may be a change in glucose control. Liver impairment: Use with caution in people with severe liver dysfunction; in cirrhosis, avoid electrolyte and acid/base imbalances that might lead to hepatic encephalopathy. Kidney failure: combined triamterene and indomethacin therapy caused reversible acute kidney injury in some people.Kidney stones: Use with caution in people with kidney stones. Use should be avoided if the creatinine clearance is less than 10 ml/minute. Mechanism of action
Triamterene directly blocks the epithelial sodium channel (ENaC) on the lumen side of the kidney collecting tubule.