Families report that affected individuals are more at ease when restrained.The Matheny Medical and Educational Center [2] in Peapack, NJ, has six Lesch–Nyhan syndrome patients, believed to be the largest concentration of LNS cases in one location, and is recognized as the leading source of information on care issues. Treatment for LNS patients, according to Gary E. Eddey, MD, medical director, should include: 1) Judicious use of protective devices; 2) Utilization of a behavioral technique commonly referred to as selective ignoring with redirection of activities; and 3) Occasional use of medications.An article in the August 13, 2007 issue of The New Yorker magazine, written by Richard Preston, discusses "deep-brain stimulation" as a possible treatment. It has been performed on a few patients with Lesch–Nyhan syndrome by Dr. Takaomi Taira in Tokyo and by a group in France led by Dr. Philippe Coubes. Some patients experienced a decrease in spastic self-injurious symptoms. The technique was developed for treating people with Parkinsons disease, according to Preston, over 20 years ago. The treatment involves invasive surgery to place wires that carry a continuous electric current into a specific region of the brain.An encouraging advance in the treatment of the neurobehavioural aspects of LNS was the publication in the October, 2006 issue of Journal of Inherited Metabolic Disease of an experimental therapy giving oral S-adenosyl-methionine (SAMe). This drug is a nucleotide precursor that provides a readily absorbed purine, which is known to be transported across the blood–brain barrier.
[3]

Epidemiology
Transient neonatal pustular melanosis occurs in as much as 15% of black newborns. [3] but in less than 1% of white newborns. [2]

See also
List of cutaneous conditions

References

1. OConnor NR, McLaughlin, MR, Ham P (2008). "Newborn Skin: Part I. Common Newborn Rashes". American Family Physician. 77 (1): 47–52. 2. Patrizi A, Neri I, Virid A, Gurioli C.(2016). "Frequent newborn skin diseases". Clinical Dermatology. 4 (3-4): 82–86. doi: 10.11138/cderm/2016.4.3.082. 3. Ghosh S. (2015). "Neonatal Pustular Dermatosis: An Overview". Indian Journal of Dermatology. 60 (2): 211. doi: 10.4103/0019-5154.152558
4. Ferrándiz C, Coroleu W, Ribera M, Lorenzo JC, Natal A (1992). "Sterile transient neonatal pustulosis is a precocious form of erythema toxicum neonatorum". Dermatology. 185:18–22. 5. Mebazaa A, Khaddar-Kort R, Cherif M, Mokni S, Haouet A, Osman B (2011). "Transient pustular eruption in neonates". Archives de Pediatrie. 18 (3) 291–293.