If Anodontia is present in the maternal or paternal side, the chances of this being inherited are increased. Mechanisms and Pathophysiology
Anodontia is a genetic disorder that is typically occurs in result of another syndrome. Different results can occur depending on which gene is inherited. It remains unclear which specific gene is the direct cause but it is known that several genes can play a role when inherited. Many genes are involved with this and other relating disorders. The main genes involved include: EDA, EDAR, and EDARADD genes. One working gene and one non-working gene are inherited, one from an affected parent and one from a non-affected parent, which then result in a 50% chance of the child inheriting the genetic disorder. Anodontia alone will not have an effect on any other body part besides teeth being missing. Associated syndromes
Hypodontia and anodontia are frequently associated with a multitude of genetic disorders and syndromes, approximately 70. Syndromes particularly involved with ectodermal involvement are a prime circumstance for anodontia to occur, some examples of these are: Riegers, Robinsons and focal dermal hypoplasia. Three syndromes which classically have signs of anodontia are oculomandibulodyscephaly, mesoectodermal dysplasia and ectodermal dysplasia. In cases of oculomandibulodyscephaly there are no permanent teeth but there are deciduous teeth present. In mesoectodermal dysplasia the symptoms are anodontia and hypodontia. In cases of ectodermal dysplasia oligodontia is also present. Other symptoms associated with anodontia include: Alopecia, loss of sweat glands, cleft lip or palate, or missing finger nails.
Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to interruption of the blood supply. Early on, there may be no symptoms. Gradually joint pain may develop which may limit the ability to move. Complications may include collapse of the bone or nearby joint surface.Risk factors include bone fractures, joint dislocations, alcoholism, and the use of high-dose steroids. The condition may also occur without any clear reason. The most commonly affected bone is the femur. Other relatively common sites include the upper arm bone, knee, shoulder, and ankle. Diagnosis is typically by medical imaging such as X-ray, CT scan, or MRI. Rarely biopsy may be used.Treatments may include medication, not walking on the affected leg, stretching, and surgery. Most of the time surgery is eventually required and may include core decompression, osteotomy, bone grafts, or joint replacement. About 15,000 cases occur per year in the United States. People 30 to 50 years old are most commonly affected. Males are more commonly affected than females. Signs and symptoms
In many cases, there is pain and discomfort in a joint which increases over time. While it can affect any bone, about half of cases show multiple sites of damage.Avascular necrosis most commonly affects the ends of long bones such as the femur. Other common sites include the humerus, knees, shoulders, ankles and the jaw. Causes
The main risk factors are bone fractures, joint dislocations, alcoholism, and the use of high-dose steroids. Other risk factors include radiation therapy, chemotherapy, and organ transplantation.