In the United Kingdom, co-amoxiclav carries a warning from the Committee on Safety of Medicines to this effect.As all aminopenicillins, amoxicillin has been associated with Stevens–Johnson syndrome/toxic epidermal necrolysis, although these reactions are very rare. History
British scientists working at Beecham (now part of GlaxoSmithKline), filed for patent protection for the drug combination in 1977, which was granted in 1982. It was sold under the brand name Augmentin. Preparations
Amoxicillin/clavulanic acid is the International Nonproprietary Name (INN) and co-amoxiclav is the British Approved Name (BAN).Many branded products indicate their strengths as the quantity of amoxicillin. Augmentin 250, for example, contains 250 mg of amoxicillin and 125 mg of clavulanic acid.An intravenous preparation has been available in the UK since 1985, but no parenteral preparation is available in the US; the nearest equivalent is ampicillin/sulbactam.Suspensions of amoxicillin/clavulanic acid are available for use in children. They must be refrigerated to maintain effectiveness. Veterinary use
Amoxicillin/clavulanic acid is used in numerous animals for a variety of conditions:

Dogs: periodontitis, kennel cough
Cats: urinary tract infections, skin and soft tissue infections
Calves: enteritis, navel ill
Cattle: respiratory tract infections, soft tissue infections, metritis, mastitis
Pigs: respiratory tract infections, colibacillosis, mastitis, metritis, agalactiaIn combination with prednisolone, it is used for intramammary infusion for the treatment of mastitis in lactating cows. Trade names include Clavaseptin, Clavamox, and Synulox.Amoxicillin/clavulanic acid is banned from use in domestic-food animals (cattle, swine, etc.) in both the US and Europe; in the UK, Synulox can be used in domestic-food animals as long as a specified withdrawal period is observed.
Secnidazole (trade names Flagentyl, Sindose, Secnil, Solosec) is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported. It has also been tested against Atopobium vaginae.In the United States, secnidazole is approved for the treatment of bacterial vaginosis and trichomoniasis in adult women. References


== Further reading ==