It is typically used after other antinausea drugs have failed.There appears to be a low risk of harm to the baby with use during pregnancy, though there may be an increase in heart problems among the babies.Ondansetron is in pregnancy category B in the US. It is not known if ondansetron is excreted in breast milk. Cyclic vomiting syndrome
Ondansetron is one of several antiemetic drugs used during the vomiting phase of cyclic vomiting syndrome. Gastroenteritis
Trials in emergency department settings support the use of ondansetron to reduce vomiting associated with gastroenteritis and dehydration. A retrospective review found it was used commonly for this purpose, being administered in over 58% of cases. Its use reduced hospital admissions, but was also associated with higher rates of return visits to the emergency department. Furthermore, people who had initially received ondansetron were more likely to be admitted on the return visit than people who had not received the drug. However, this effect may simply be due to the agent being used more frequently in people who present with more severe illness. Its use was not found to mask serious diagnoses. Special populations
Children
Ondansetron has rarely been studied in people under 4 years of age. As such, little data is available to guide dosage recommendations. Elderly
It is not necessary to adjust the dosage for people under 75 years of age. The use of ondansetron has not been studied in people older than 75 years of age, and it is not known if dosage should be adjusted for this group.
Bimatoprost, sold under the brand name Lumigan among others, is a medication used to treat high pressure inside the eye including glaucoma. Specifically it is used for open angle glaucoma when other agents are not sufficient. It may also be used to increase the size of the eyelashes. It is used as an eye drop and effects generally occur within four hours.Common side effects include red eyes, dry eyes, change in color of the eyes, blurry vision, and cataracts. Use during pregnancy or breastfeeding is generally not recommended. It is a prostaglandin analog and works by increasing the outflow of aqueous fluid from the eyes.Bimatoprost was approved for medical use in the United States in 2001. It is available as a generic medication. In 2018, it was the 274th most commonly prescribed medication in the United States, with more than 2 million prescriptions. Uses
Medical
Bimatoprost is used for the treatment of open-angle glaucoma and ocular hypertension in adults, either alone or in combination with a beta blocker, typically timolol.Studies have shown bimatoprost to be more effective than timolol in reduction of intraocular pressure (IOP) and at least as effective as the prostaglandin analogs latanoprost and travoprost in reducing IOP. Cosmetic
Bimatoprost may be used to treat small or underdeveloped eyelashes. The medical term for this is treatment of hypotrichosis; however, the U.S. Food and Drug Administration (FDA) approval is for purely cosmetic purposes (see Prostaglandin F receptor#Clinical significance). Side effects
Side effects are similar to other prostaglandin analogs applied to the eye.