WHO Drug Information advises against its use in primary sclerosing cholangitis in unapproved doses beyond 13–15 mg/kg/day.UDCA in a dose of 28-30mg/kg/day increases risk of death and need for liver transplant by 2.3 folds among those with primary sclerosing cholangitis, despite decrease in liver enzymes. Intrahepatic cholestasis of pregnancy
UDCA has been used for intrahepatic cholestasis of pregnancy. UDCA lessens itching in the mother and may reduce the number of preterm births. Effects on fetal distress and other adverse outcomes are unlikely to be great. Cholestasis
UDCA use is not licensed in children, as its safety and effectiveness have not been established. Evidence is accumulating that ursodeoxycholic acid is ineffective, unsafe and its use is associated with significant risk of morbidity and mortality in neonatal hepatitis and neonatal cholestasis. Other conditions
UDCA has been suggested to be an adequate treatment of bile reflux gastritis.In cystic fibrosis there is insufficient evidence to justify routine use of UDCA, especially as there is a lack of available data for long-term outcomes such as death or need for liver transplantation.UDCA has also been in effective in non-alcoholic fatty liver disease, in liver bile duct-paucity syndromes. It is contraindicated in obstruction of biliary tracts such as biliary atresia. Its not effective in liver allograft rejection, and in Graft-versus-host disease involving the liver. Adverse effects
Diarrhea was the most frequent adverse event seen in trial of UDCA in gallstone dissolution, occurring in 2 to 9%, which is less frequent than with chenodeoxycholic acid therapy.
Dissociation, in the wide sense of the word, is an act of disuniting or separating a complex object into parts. Dissociation may also refer to:

Dissociation (chemistry), general process in which molecules or ionic compounds (complexes, or salts) split into smaller particles, usually in a reversible manner
Dissociation (neuropsychology), identification of the neural substrate of a particular brain function through various methods
Dissociation (psychology), an experience of having ones attention and emotions detached from the environment
Dissociation (rhetoric), a rhetorical device in which the speaker separates a notion considered to form a unitary concept into two new notions to affect an audience in some way
Dissociation (album), by the Dillinger Escape Plan, 2016

See also
Dissociation: Progress in the Dissociative Disorders (1988-1997) published by International Society for the Study of Trauma and Dissociation
"Disassociation", a 2021 song by the Rions
Dissociative, a class of hallucinogen
All pages with titles beginning with Dissociation
All pages with titles containing Dissociation