Treatment
Supervised exercise programs have been shown in small studies to improve exercise capacity by several measures.Oral sucrose treatment (for example a sports drink with 75 grams of sucrose in 660 ml.) taken 30 minutes prior to exercise has been shown to help improve exercise tolerance including a lower heart rate and lower perceived level of exertion compared with placebo.A low dosage treatment with creatine showed a significant improvement of muscle problems compared to placebo in a small clinical study. History
The deficiency was the first metabolic myopathy to be recognized, when Dr. McArdle described the first case in a 30-year-old man who always experienced pain and weakness after exercise. Dr. McArdle noticed this patients cramps were electrically silent and his venous lactate levels failed to increase upon ischemic exercise. (The ischemic exercise consists of the patient squeezing a hand dynamometer at maximal strength for a specific period of time, usually a minute, with a blood pressure cuff, which is placed on the upper arm and set at 250 mmHg, blocking blood flow to the exercising arm.) Notably, this is the same phenomenon that occurs when muscle is poisoned by iodoacetate, a substance that blocks breakdown of glycogen into glucose and prevents the formation of lactate. Dr. McArdle accurately concluded that the patient had a disorder of glycogen breakdown that specifically affected skeletal muscle. The associated enzyme deficiency was discovered in 1959 by W. F. H. M. Mommaerts et al.
This renders eight possible categories, six of which Mellor was able to find multiple criminal offenders to exemplify:

This typology is compatible with the necrophilia typology, producing hybrid categories which help to understand the totality of the offenders paraphilic desires. See also
Sexual masochism disorder
Biastophilia
Lust murder
Marquis de Sade, after whom sadism is named
Sadistic personality disorder

References


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