These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine. The macular changes are potentially serious. Advanced retinopathy is characterized by reduction of visual acuity and a "bulls eye" macular lesion which is absent in early involvement. Overdose
Overdoses of hydroxychloroquine are extremely rare, but extremely toxic. Eight people are known to have overdosed since the drugs introduction in the mid-1950s, of which three have died. Chloroquine has a risk of death in overdose in adults of about 20%, while hydroxychloroquine is estimated to be two or threefold less toxic.Serious signs and symptoms of overdose generally occur within an hour of ingestion. These may include sleepiness, vision changes, seizures, coma, stopping of breathing, and heart problems such as ventricular fibrillation and low blood pressure. Loss of vision may be permanent. Low blood potassium, to levels of 1 to 2 mmol/L, may also occur. Cardiovascular abnormalities such as QRS complex widening and QT interval prolongation may also occur.Treatment recommendations include early mechanical ventilation, heart monitoring, and activated charcoal. Supportive treatment with intravenous fluids and vasopressors may be required with epinephrine being the vasopressor of choice. Stomach pumping may also be used. Sodium bicarbonate and hypertonic saline may be used in cases of severe QRS complex widening. Seizures may be treated with benzodiazepines. Intravenous potassium chloride may be required, however this may result in high blood potassium later in the course of the disease. Dialysis does not appear to be useful.
He also opines that he thinks half his children are freaks, blaming this and the fact that there were so many at once, on the fact that they were artificially inseminated. Carol Chase (Rebecca Creskoff) – The mother maintains the large family and house in "typical sitcom homemaker" mode. In one episode she attempts to go back to work, but nobody wants her because shes been raising kids for 15 years. She goes back to being a homemaker and remains one for the rest of the show. She enforces the house rules. Parker Chase (Jake McDorman) – The popular boy. Tallest of the children, good-looking, successful in academics and sports. He teases his brothers mercilessly, especially Pearce, but is also quick to defend them. The male quints share a deep bond, probably from sharing the womb. At one point the youngest and shortest, Patton, says that Parker took all the good genes and left him with the short ones and Pearce with the weird ones. Pearce Chase (Johnny K. Lewis) – The curly-haired weirdest quint. He boldly shares with anyone his strange perspective on just about any subject, and is so odd that he no longer responds to rejection. Penny Chase (April Matson) – The intellectual, who is vigorously nonconformist. Her taste in clothing and hairstyle frequently gets her mistaken for the typical goth. She enjoys reading and sometimes feels inadequate to Paige. Paige Chase (Sarah Wright) – The beautiful girl. She spends most of her time thinking of and attending to her appearance.