In her earliest appearances, the character was drawn with a closed-cropped hairdo which had two small white streaks originating above her temples and reaching back over her ears to the back of her head. Over time, she came to be drawn with a larger section of white hair at her forelock, although its size varies greatly from artist to artist. This visual aspect of Rogues appearance has been consistently portrayed in every adaptation of the character, however, in the 2000 X-Men live action film, Rogue is shown to initially have all brown hair, developing the permanent white streak after being forced to absorb a significant amount of power from Magneto.The characters Percy Jackson and Annabeth Chase each develop a white streak in their hair from the strain of holding up the sky in The Titans Curse, the third novel in the book series Percy Jackson and the Olympians.Cruella De Vil is thought of to have this condition with her half black / half white hair.The main character Jio Fleed of the Satan 666 manga series seems to have the condition.During his Christmas special, Jeff Dunham was doing a bit with Achmed the Dead Terrorist and mistakenly combined scoliosis with polio, making poliosis.A Mallen streak is a minor plot point in the 2021 film Dont Breathe 2.In the popular web series Dream SMP, the character Wilbur Soot - played by the content creator of the same name - develops a prominent Mallen streak from the stress of being magically revived.
The applicant for this medicinal product is Merck Europe B.V. Tepotinib (Tepmetko) was approved for medical use in the European Union in February 2022. References
Further reading
Paik PK, Felip E, Veillon R, Sakai H, Cortot AB, Garassino MC,  et al. (September 2020). "Tepotinib in Non-Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations". N Engl J Med. 383 (10): 931–43. doi:10.1056/NEJMoa2004407. PMC 8422679. PMID 32469185. External links
"Tepotinib". Drug Information Portal. U.S. National Library of Medicine. "Tepotinib hydrochloride". Drug Information Portal. U.S. National Library of Medicine. "Tepotinib hydrochloride". NCI Drug Dictionary. National Cancer Institute. Clinical trial number NCT02864992 for "Tepotinib Phase II in Non-small Cell Lung Cancer (NSCLC) Harboring MET Alterations (VISION)" at ClinicalTrials.gov