Possible adverse effects of use of benzodiazepines such as clonazepam during pregnancy include: miscarriage, malformation, intrauterine growth retardation, functional deficits, carcinogenesis, and mutagenesis. Neonatal withdrawal syndrome associated with benzodiazepines include hypertonia, hyperreflexia, restlessness, irritability, abnormal sleep patterns, inconsolable crying, tremors, or jerking of the extremities, bradycardia, cyanosis, suckling difficulties, apnea, risk of aspiration of feeds, diarrhea and vomiting, and growth retardation. This syndrome can develop between three days to three weeks after birth and can have a duration of up to several months. The pathway by which clonazepam is metabolized is usually impaired in newborns. If clonazepam is used during pregnancy or breastfeeding, it is recommended that serum levels of clonazepam are monitored and that signs of central nervous system depression and apnea are also checked for. In many cases, non-pharmacological treatments, such as relaxation therapy, psychotherapy, and avoidance of caffeine, can be an effective and safer alternative to the use of benzodiazepines for anxiety in pregnant women. Pharmacology
Mechanism of action
Clonazepam enhances the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system to give its anticonvulsant, skeletal muscle relaxant, and anxiolytic effects. It acts by binding to the benzodiazepine site of the GABA receptors, which enhances the electric effect of GABA binding on neurons, resulting in an increased influx of chloride ions into the neurons. This further results in an inhibition of synaptic transmission across the central nervous system.Benzodiazepines do not have any effect on the levels of GABA in the brain.
Snatiation is a term coined to refer to the a medical condition originally termed "stomach sneeze reflex", which is characterized by uncontrollable bursts of sneezing brought on by fullness of the stomach, typically immediately after a large meal. The type of food consumed does not appear to affect its occurrence. It is reported, based on a preliminary study, to be passed along genetically as an autosomal dominant trait, as first described by Ahmad Teebi and Qasem Al-Saleh in 1989. The term "snatiation", coined shortly thereafter in a humorous letter to the Journal of Medical Genetics by Judith G. Hall, is a portmanteau of the words sneeze and satiation. Similar in nature to this condition is gustatory rhinitis, which involves rhinorrhea induced by certain foods, such as spicy foods. See also
Photic sneeze reflex

References
External links
Online Mendelian Inheritance in Man (OMIM): Gastric Sneezing - 137130