Ranolazine, sold under the brand name Ranexa among others, is a medication used to treat heart related chest pain. Typically it is used together with other medications when those are insufficient. Benefits appear smaller in women than men. It is taken by mouth.Common side effects include constipation, headache, nausea, and dizziness. Serious side effects may include QT prolongation. Use is not recommended in those with liver cirrhosis. How it works is not clear but may involve adenosine triphosphate.Ranolazine was approved for medical use in the United States in 2006. In 2019, it was the 211th most commonly prescribed medication in the United States, with more than 2 million prescriptions. Medical uses
Ranolazine is used to treat chronic angina. It may be used concomitantly with β blockers, nitrates, calcium channel blockers, antiplatelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers. It is also effective at preventing atrial fibrillation, and has been studied as monotherapy as well as in combination with other medications used to treat irregular heartbeat.Its use is not recommended in Scotland as of 2019. Contraindications
Some contraindications for ranolazine are related to its metabolism and are described under Drug Interactions. Additionally, in clinical trials ranolazine slightly increased QT interval in some patients and the FDA label contains a warning for doctors to beware of this effect in their patients. The drugs effect on the QT interval is increased in the setting of liver dysfunction; thus it is contraindicated in persons with mild to severe liver disease.
Physical abuse can be detected by visible signs on the body including bruises, scratches, scars, sprains, or broken bones. More subtle indications of physical abuse include signs of restraint such as rope marks on the  wrist or broken eyeglasses. Emotional abuse often accompanies the other types of abuse and can usually be detected by changes in the persons personality or behavior. The elder may also exhibit behavior mimicking dementia, such as rocking or mumbling. Emotional abuse is the most under reported abuse of elder abuse. Elder abuse occurs when a person fails to treat an elder with respect and includes verbal abuse. The elder experiences social isolation or lack of acknowledgement in this type of abuse. Some indicators of the emotional effects of elder abuse is the elder adult being unresponsive or uncommunicative. Also they can be unreasonably suspicious or fearful, more isolated, and not wanting to be as social as they may have been before. Emotional abuse is under reported but can have the most damaging effects because it leads to more physical and mental health problems. Financial exploitation is a more subtle form of abuse, in comparison to other types, and may be more challenging to notice. Signs of financial exploitation include significant withdrawals from accounts, belongings or money missing from the home, unpaid bills, and unnecessary goods or services. Sexual abuse, like physical abuse, can be detected by visible signs on the body, especially around the breasts or genital area. Other signs include inexplicable infections, bleeding, and torn underclothing.