They were separated at birth by Dr. Hibbert and Hugo was imprisoned in the Simpsons attic. The Oblongs, depicts  Biff Oblong (Randy Sklar) and Chip Oblong (Jason Sklar)—17-year-old conjoined twins who are attached at the waist and share a middle leg due to their valleys pollution and radiation. In the DC Comics series Hitman, villain Moe and Joe Dubelz is a conjoined twin gangster. Moe was alive at the time of introduction, but Joe had already died and is, in fact, undergoing putrefaction. In the episode "Humbug" of The X-Files, Vincent Schiavelli portrayed a circus performer named Lanny, with an underdeveloped conjoined twin named Leonard. The episode also includes a reference to Chang and Eng. The Prophet of Yonwood has a reference to Chang and Eng when the main character, Nickie, finds a picture of them in her great-grandfathers old house in Siam. In the anime Naruto, Sakon (左近) and his conjoined twin brother Ukon (右近) are the strongest of the Sound Four and count as one member due to their abilities to merge bodies and kill an opponent at a cellular level. They both serve as antagonists. The Broadway musical Side Show depicts the lives of real-life conjoined twins Daisy and Violet Hilton, portrayed in the original Broadway production by Alice Ripley and Emily Skinner. The American medical drama Greys Anatomy featured several cases of conjoined twins. The 2001 movie Not Another Teen Movie depicts Kara and Sara Fratelli, conjoined twins portrayed by Samaire Armstrong and Nectar Rose.
In the fourth season of the American television series American Horror Story titled American Horror Story: Freak Show, the main character Bette and Dot Tattler (Sarah Paulson in a dual role) are a dicephalic parapagus twin where their two heads are side by side on one torso. This performance is done with the help of CGI. In season two, episode eight of Rick and Morty, Michael and Pichael Thompson (voiced by Justin Roiland) are depicted as conjoined twins hosting separate TV shows at the same time. In the Cirque Du Soleil show Kurios: Cabinetes des Curiosities, a pair of conjoined twins are among the Seekers collection. They later split during an aerial straps duo and reunite for the rest of the show. The bilingual film Chaarulatha stars Priyamani as a conjoined twin. In the Disney-distributed movie Jagga Jasoos, starring Ranbir Kapoor and Katrina Kaif, Basheer Alexander is shown with two heads. On the television series Ruby Gloom, the characters Frank and Len are conjoined twins who comprise a rock group called RIP. In the film Monsters University, two of the members of the fictitious fraternity Oozma Kappa are named Terri and Terry Perry (voiced by Sean Hayes and Dave Foley). They are dicephalic parapagus twins where they have four arms and share the same tentacles that are in place of their legs. In the childrens cartoon Steven Universe, the Rutile twins are conjoined. Fire and Water are conjoined twins in Chris Abanis 2014 novel The Secret History of Las Vegas.