The target of ravulizumab-cwvz is the same eculizumab (Soliris) with changes to the structure of the antibody resulting in a longer serum half life and therefore reduced dosing regimen. Dialysis
Patients with aHUS who have ESRD are generally consigned to lifelong dialysis, which carries a 5-year survival rate of 34–38%, with infections accounting for 14% of deaths. These patients also remain at ongoing risk of non-kidney systemic complications of the disease. Kidney transplantation
Despite its history of use in patients with aHUS, kidney transplantation does not address the continued and uncontrolled complement activation that leads to progressive, systemic TMA. As many as 90% of patients with aHUS and who are not treated with Soliris or Ultomiris, experience TMA in the transplanted organ, leading to transplant failure. Patients who have undergone kidney transplantation are still at continued risk of neurological, gastrointestinal, and cardiovascular complications and, importantly, premature mortality. Following kidney transplantation, the ongoing, uncontrolled, chronic complement activation associated with aHUS causes graft loss in 66% of children and 55% of adults, as well as continued inflammatory and TMA insult to other organs. Combined liver-kidney transplantation is only available to very few patients, due to the limited supply of solid organs. In addition, there is a substantial near-term risk of mortality, which many physicians and patients consider excessive. In recent years, some transplant centers have begun to administer eculizumab to patients with TMA who receive a kidney transplant. This strategy has been effective in preventing TMA recurrences in these patients.
Snatiation is a term coined to refer to the a medical condition originally termed "stomach sneeze reflex", which is characterized by uncontrollable bursts of sneezing brought on by fullness of the stomach, typically immediately after a large meal. The type of food consumed does not appear to affect its occurrence. It is reported, based on a preliminary study, to be passed along genetically as an autosomal dominant trait, as first described by Ahmad Teebi and Qasem Al-Saleh in 1989. The term "snatiation", coined shortly thereafter in a humorous letter to the Journal of Medical Genetics by Judith G. Hall, is a portmanteau of the words sneeze and satiation. Similar in nature to this condition is gustatory rhinitis, which involves rhinorrhea induced by certain foods, such as spicy foods. See also
Photic sneeze reflex

References
External links
Online Mendelian Inheritance in Man (OMIM): Gastric Sneezing - 137130