Repair of DNA damaged by chemicals or irradiation is also inhibited by hydroxyurea, offering potential synergy between hydroxyurea and radiation or alkylating agents.Hydroxyurea has many pharmacological applications under the Medical Subject Headings classification system:
Antineoplastic Agents – Substances that inhibit or prevent the proliferation of neoplasms. Antisickling Agents – Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions. Nucleic Acid Synthesis Inhibitors – Compounds that inhibit cell production of DNA or RNA. Enzyme Inhibitors – Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. Cytochrome P-450 CYP2D6 Inhibitors – Acts as an inhibitor to one of the most important enzymes involved in the metabolism of xenobiotics in the body, CYP2D6 a member of the cytochrome P450 mixed oxidase system. Society and culture
Brand names
Brand names include: Hydrea, Litalir, Droxia, and Siklos. References
External links
"Hydroxyurea". Drug Information Portal. U.S. National Library of Medicine.
Researchers predict that if this upwards trend continues, the amount of food insecure seniors will increase by 50% by 2025.This age group suffers the most from chronic conditions, including heart disease, diabetes, and respiratory diseases. Eighty percent of this group has a minimum of one chronic condition, and almost 70% have two or more. These illnesses are exacerbated and are more likely to develop under the addition of hunger. A report from 2017 shows that seniors facing this issue are 60% more likely to experience depression than seniors who are not hungry, and 40% are more likely to develop congestive heart failure. The added stress of inconsistent and inadequate feedings make these conditions much more dangerous.Fixed incomes often limit the elderly’s ability to freely purchase food necessities. Medical costs and housing may take priority over quality foods. Limited mobility makes it difficult for these individuals to physically leave their homes, especially in areas lacking public transportation or transportation catering to a disabled body. The COVID-19 pandemic has made things even more difficult, as this group is extremely vulnerable to contracting variants. They are high-risk, and are faced with the threat of this disease, more so than other age groups, when they leave their homes. This continues to limit their food access. The Supplemental Nutrition Assistance Program (SNAP) provides aid to low-income seniors in relation to food security. This is an opportunity for seniors who receive benefits to allocate money in their budgets for other needs, such as medical or housing bills. However, participation is extremely low.