Film
Films attempting to depict characters with the disorder include A Thin Line Between Love and Hate (1996), Gia (1998), Filth (2013), Fatal Attraction (1987), The Crush (1993), Mad Love (1995), Malicious (1995), Interiors (1978), The Cable Guy (1996), Mr. Nobody (2009), Moksha (2001), Margot at the Wedding (2007), Cracks (2009), Welcome to Me (2014), and Tamasha (2015).Robert O. Friedel has suggested that the behavior of Theresa Dunn, the leading character of Looking for Mr. Goodbar (1975) is consistent with a diagnosis of borderline personality disorder.The films Play Misty for Me (1971) and Girl, Interrupted (1999, based on the memoir of the same name) both suggest the emotional instability of the disorder.The film Single White Female (1992), like the first example, also suggests characteristics, some of which are actually atypical of the disorder: the character Hedy had markedly disturbed sense of identity and reacts drastically to abandonment. : 235 Multiple commenters have noted that Clementine in Eternal Sunshine of a Spotless Mind (2004) shows classic borderline personality disorder behavior.In a review of the film Shame (2011) for the British journal The Art of Psychiatry, another psychiatrist, Abby Seltzer, praises Carey Mulligans portrayal of a character with the disorder even though it is never mentioned onscreen.Psychiatrists Eric Bui and Rachel Rodgers argue that the Anakin Skywalker/Darth Vader character in the Star Wars films meets six of the nine diagnostic criteria; Bui also found Anakin a useful example to explain BPD to medical students. In particular, Bui points to the characters abandonment issues, uncertainty over his identity, and dissociative episodes.
Adverse events
Serious adverse events, which can cause death and disability, include:
Severe infusion reaction
Cardiac arrest
Cytokine release syndrome
Tumor lysis syndrome, causing acute kidney injury
Infections
Hepatitis B reactivation
Other viral infections
Progressive multifocal leukoencephalopathy (PML) caused by JC virus reactivation
Invasive fungal infections 
Immune toxicity, with depletion of B cells in 70% to 80% of lymphoma patients
Pulmonary toxicity
Bowel obstruction and perforationTwo patients with systemic lupus erythematosus died of progressive multifocal leukoencephalopathy (PML) after being treated with rituximab. PML is caused by activation of JC virus, a common virus in the brain which is usually latent. Reactivation of the JC virus usually results in death or severe brain damage.At least one patient with rheumatoid arthritis developed PML after treatment with rituximab.Rituximab has been reported as a possible cofactor in a chronic hepatitis E infection in a person with lymphoma. Hepatitis E infection is normally an acute infection, suggesting the drug in combination with lymphoma may have weakened the bodys immune response to the virus.A major concern with continuous rituximab treatment is the difficulty to induce a proper vaccine response. This was brought into focus during the COVID-19 pandemic, where persons with multiple sclerosis and rituximab treatment had higher risk of severe COVID-19. In persons with rituximab treatment for multiple sclerosis, 9 of 10 patients with B cell counts of 40/µL or more developed protective levels of antibodies after vaccination with tozinameran. Mechanisms of action
The antibody binds to the cell surface protein CD20.