T1A – One vocal cord
T1B – Both vocal cordsT2: Tumour meets at least one of the following criteria:

extends to supra- or sub-glottis
impairs vocal cord mobilityT3: Tumour meets at least one of the following criteria:

causes fixation of the vocal cords
invades the paraglottic space
involves the thyroid cartilage’s inner cortexT4: Same as “Supraglottis”

Subglottis
T1: Tumour is only in the subglottis
T2: Tumour involves both subglottis and vocal cords (regardless of cord mobility)
T3: Same as “Glottis”
T4: Same as “Supraglottis”

N
If Using Clinical (Non-Pathological) Diagnosis
NX: Unable to assess
N0: No involvement of neighbouring lymph nodes
N1: Tumour meets ALL of the following criteria:

involves single lymph node
involved lymph node on the same side of the body as tumour
involved lymph node less than 3 cm in “greatest dimension”
lacks extension beyond the lymph nodeN2: Tumour meets ANY of the following criteria

N2A – Same as N1, except size can be between 3–6 cm
N2B – Same as N2A, except lymph nodes can be  multiple, and there is no minimum size
N2C – Same as N2B, except lymph nodes can be on any side of the bodyN3: Tumour meets ANY of the following criteria:

N3A – Same as N1, except size is greater than 6 cm
N3B – Tumour obviously extends beyond the lymph node border (regardless of number, size, or location of lymph nodes)If Using Pathological Diagnosis
NX: Same as “Clinical Diagnosis – NX”
N0:  Same as “Clinical Diagnosis – N0”
N1:  Same as “Clinical Diagnosis – N1”
N2: Tumour meets ANY of the following criteria

N2A – Same as “Clinical Diagnosis – N2A”, except tumour can extend beyond the involved lymph node
N2B – Same as “Clinical Diagnosis – N2B”
N2C – Same as “Clinical Diagnosis – N2C”N3: Tumour meets ANY of the following criteria:

N3A – Same as “Clinical Diagnosis – N3A”
N3B – Any provable presence of tumour extension beyond the lymph node

M
M0: No evidence of distant metastasis
M1: Evidence of distant metastasis

Treatment
Specific treatment depends on the location, type, and stage of the tumour.
It was a limiting factor in long-distance sea travel, often killing large numbers of people. During the Age of Sail, it was assumed that 50 percent of the sailors would die of scurvy on a major trip. A Scottish surgeon in the Royal Navy, James Lind, is generally credited with proving that scurvy can be successfully treated with citrus fruit in 1753. Nevertheless, it was not until 1795 that health reformers such as Gilbert Blane persuaded the Royal Navy to routinely give lemon juice to its sailors. Signs and symptoms
Early symptoms are malaise and lethargy. After one to three months, patients develop shortness of breath and bone pain. Myalgias may occur because of reduced carnitine production. Other symptoms include skin changes with roughness, easy bruising and petechiae, gum disease, loosening of teeth, poor wound healing, and emotional changes (which may appear before any physical changes). Dry mouth and dry eyes similar to Sjögrens syndrome may occur. In the late stages, jaundice, generalised edema, oliguria, neuropathy, fever, convulsions, and eventual death are frequently seen. Cause
Scurvy, including subclinical scurvy, is caused by a deficiency of dietary vitamin C since humans are unable to metabolically synthesize vitamin C. Provided the diet contains sufficient vitamin C, the lack of working L-gulonolactone oxidase (GULO) enzyme has no significance, and in modern Western societies, scurvy is rarely present in adults, although infants and elderly people are affected. Virtually all commercially available baby formulas contain added vitamin C, preventing infantile scurvy.