All three of the compounds share a common 3-trifluoromethylaniline moiety. Bicalutamide is a modification of flutamide in which a 4-fluorophenylsulfonyl moiety has been added and the nitro group on the original phenyl ring has been replaced with a cyano group. Topilutamide, also known as fluridil, is another NSAA that is closely related structurally to the first-generation NSAAs, but, in contrast to them, is not used in the treatment of prostate cancer and is instead used exclusively as a topical antiandrogen in the treatment of pattern hair loss. The second-generation NSAAs enzalutamide and apalutamide were derived from and are analogues of the first-generation NSAAs, while another second-generation NSAA, darolutamide, is said to be structurally distinct and chemically unrelated to the other NSAAs. Enzalutamide is a modification of bicalutamide in which the inter-ring linking chain has been altered and cyclized into a 5,5-dimethyl-4-oxo-2-thioxo imidazolidine moiety. In apalutamide, the 5,5-dimethyl groups of the imidazolidine ring of enzalutamide are cyclized to form an accessory cyclobutane ring and one of its phenyl rings is replaced with a pyridine ring. The first nonsteroidal androgens, the arylpropionamides, were discovered via structural modification of bicalutamide. Unlike bicalutamide (which is purely antiandrogenic), these compounds show tissue-selective androgenic effects and were classified as selective androgen receptor modulators (SARMs). Lead SARMs of this series included acetothiolutamide, enobosarm (ostarine; S-22), and andarine (acetamidoxolutamide or androxolutamide; S-4).
In the case of normal faults, the rock mass is pushed down in a vertical direction, thus the pushing force (greatest principal stress) equals the weight of the rock mass itself. In the case of thrusting, the rock mass "escapes" in the direction of the least principal stress, namely upward, lifting the rock mass, and thus, the overburden equals the least principal stress. Strike-slip faulting is intermediate between the other two types described above. This difference in stress regime in the three faulting environments can contribute to differences in stress drop during faulting, which contributes to differences in the radiated energy, regardless of fault dimensions. Energy released
For every unit increase in magnitude, there is a roughly thirtyfold increase in the energy released. For instance, an earthquake of magnitude 6.0 releases approximately 32 times more energy than a 5.0 magnitude earthquake and a 7.0 magnitude earthquake releases 1,000 times more energy than a 5.0 magnitude earthquake. An 8.6 magnitude earthquake releases the same amount of energy as 10,000 atomic bombs of the size used in World War II.This is so because the energy released in an earthquake, and thus its magnitude, is proportional to the area of the fault that ruptures and the stress drop. Therefore, the longer the length and the wider the width of the faulted area, the larger the resulting magnitude. The most important parameter controlling the maximum earthquake magnitude on a fault, however, is not the maximum available length, but the available width because the latter varies by a factor of 20.