Diagnosis
The following diagnostic methods can be used to diagnose Wolfram-like syndrome

Genetic mutation responsible for Wolfram-like syndrome
Genetic testingWhole exome sequencing
Whole genome sequencing
Gene sequencing focused on the WFS1 gene

Diabetes
Blood testsBlood sugar test at a random time
Fasting blood sugar test
A1C test
Oral glucose tolerance testing

Hearing loss
At-homeHearing loss screening mobile apps
Whisper test
In clinical settingAudiometer tests
Tuning fork test
Physical examination

Optic atrophy
OphthalmoscopyOptic disc examination, paleness strongly indicates optic atrophy
Visual acuity examination

Psychiatric symptoms
Depression
Use of the DSM-5 depression diagnosis criteria
Physical examination
Laboratory studies
Psychiatric evaluation

Anxiety
Use of the DSM-5 criteria for anxiety disorder
Psychological evaluation

Hallucinations (with or without delusions and/or disconnection from reality)
Hallucinations dont necessarily need to have an official clinical diagnosis (although one can be useful for treatment to be performed), but it can be used as a diagnostic method for other conditions such as psychosis or schizophrenia. Hallucinations can be auditory, visual, tactile, olfactory, or gustatory, and they involve a false perception of stimuli where there is none. The same (no necessary need for official clinical diagnosis but can be used as a diagnostic method for other conditions) goes for delusions, there are various types of delusions, including somatic, persecutory/paranoid, grandiose, etc. They involve a false, fixed, often irrational belief a person fully believes in and is hard to convince out of. Treatment
There is no standard management method for Wolfram-like syndrome, however, the following treatment methods can be used to treat the symptoms Wolfram-like syndrome causes. Diabetes
Insulin intake
Regular blood sugar monitoring
The use of metformin medication
Healthy eating habits
Regular physical activity

Hearing loss
Hearing aids
Cochlear implants
Surgical procedures

Vision loss
Optical aids
Surgical procedures
Medication

Psychiatric symptoms
Therapy (for depression, anxiety, etc.) Use of medication (antidepressants, antipsychotics, etc.)
Bupivacaine/meloxicam, sold under the brand name Zynrelef, is a fixed-dose combination medication used to treat pain in small to medium-sized wounds after surgery. It contains bupivacaine and meloxicam.The most common side effects of bupivacaine/meloxicam are dizziness, constipation, vomiting, and headache.It was approved for medical use in the European Union in September 2020, and in the United States in May 2021. Medical uses
In the European Union, the combination bupivacaine/meloxicam is indicated for treatment of somatic postoperative pain from small- to medium-sized surgical wounds in adults.In the United States it is indicated for soft tissue or periarticular instillation to produce postsurgical analgesia for up to 72 hours after bunionectomy, open inguinal herniorrhaphy, and total knee arthroplasty in adults. References
External links
"Bupivacaine mixture with meloxicam". Drug Information Portal. U.S. National Library of Medicine. Clinical trial number NCT03295721 for "Bunionectomy Study for Postoperative Analgesia (EPOCH 1)" at ClinicalTrials.gov
Clinical trial number NCT03237481 for "Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)" at ClinicalTrials.gov
Clinical trial number NCT03015532 for "Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia" at ClinicalTrials.gov