Progressive pseudorheumatoid disyplasia (PPD or PPAC) is a disorder of bone and cartilage that affects many joints. The disorder leads to stiff joints, short stature and widening of the ends of the finger and toe bones as well as other tubular bones. Cause
PPD is due to a mutation in the Wnt1-inducible signalling protein 3 (WISP3) gene, which encodes a signalling factor involved in cartilage homeostasis. Symptoms
Symptoms are present typically between ages three and six years. Abnormal walking pattern
Weakness/fatigue
Stiffness in the joints of the fingers and knees

Diagnosis
Treatment
Prognosis
PPD has no severe effect on life span. Epidemiology
PPD is an extremely rare disease. In the United States the disease is estimated to affect less than 5,000 people and approximately 1 per million people in the United Kingdom however it is believed to be more common in Turkey and the Middle East. == References ==
A placental infarction results from the interruption of blood supply to a part of the placenta, causing its cells to die. Small placental infarcts, especially at the edge of the placental disc, are considered to be normal at term. Large placental infarcts are associated with vascular abnormalities, e.g. hypertrophic decidual vasculopathy, as seen in hypertension. Very large infarcts lead to placental insufficiency and may result in fetal death. Relation to maternal floor infarct
Maternal floor infarcts are not considered to be true placental infarcts, as they result from deposition of fibrin around the chorionic villi, i.e. perivillous fibrin deposition. See also
Placental disease

References
External links

Gross pathology of a placental infarct (utah.edu)