Once nucleus accumbens ΔFosB is sufficiently overexpressed, it begins to increase the severity of addictive behavior (i.e., compulsive drug-seeking) with further increases in its expression. While there are currently no effective drugs for treating amphetamine addiction, regularly engaging in sustained aerobic exercise appears to reduce the risk of developing such an addiction. Sustained aerobic exercise on a regular basis also appears to be an effective treatment for amphetamine addiction; exercise therapy improves clinical treatment outcomes and may be used as an adjunct therapy with behavioral therapies for addiction. Biomolecular mechanisms
Chronic use of amphetamine at excessive doses causes alterations in gene expression in the mesocorticolimbic projection, which arise through transcriptional and epigenetic mechanisms. The most important transcription factors that produce these alterations are Delta FBJ murine osteosarcoma viral oncogene homolog B (ΔFosB), cAMP response element binding protein (CREB), and nuclear factor-kappa B (NF-κB). ΔFosB is the most significant biomolecular mechanism in addiction because ΔFosB overexpression (i.e., an abnormally high level of gene expression which produces a pronounced gene-related phenotype) in the D1-type medium spiny neurons in the nucleus accumbens is necessary and sufficient for many of the neural adaptations and regulates multiple behavioral effects (e.g., reward sensitization and escalating drug self-administration) involved in addiction. Once ΔFosB is sufficiently overexpressed, it induces an addictive state that becomes increasingly more severe with further increases in ΔFosB expression.
The epoophoron or epoöphoron (also called organ of Rosenmüller or the parovarium) is a remnant of the mesonephric tubules that can be found  next to the ovary and fallopian tube. Anatomy
It may contain 10–15 transverse small ducts or tubules that lead to the Gartner’s duct (also longitudinal duct of epoophoron) that represents the caudal remnant of the mesonephric duct and  passes through the broad ligament and the lateral wall of the cervix and vagina. The epoophoron is a homologue to the epididymis in the male. While the epoophoron is located in the lateral portion of the mesosalpinx and mesovarium, the paroophoron (residual remnant of that part of the mesonephric duct that forms the paradidymis in the male) lies more medially in the mesosalpinx. Histology
It has a unique histological profile. Clinical significance
Clinically the organ may give rise to a local paraovarian cyst or adenoma. See also
List of homologues of the human reproductive system
Vesicular appendages of epoophoron

References
External links
figures/chapter_35/35-8.HTM: Basic Human Anatomy at Dartmouth Medical School
genital-016a—Embryo Images at University of North Carolina
Swiss embryology (from UL, UB, and UF) ugenital/genitinterne05