It does not, however, replace the current treatment regimen.It is not useful in chronic neurological disorders, such as cerebral palsy or other dyskinesias.Currently, there is some suggestion that muscle relaxants may improve the symptoms of rheumatoid arthritis; however, there is insufficient data to prove its effectiveness as well as answer concerns regarding optimal dosing, choice of muscle relaxant, adverse effects, and functional status. Comparison to similar agents
The clinical effectiveness of methocarbamol compared to other muscle relaxants is not well-known. One trial of methocarbamol versus cyclobenzaprine, a well-studied muscle relaxant, in those with localized muscle spasm found there was no significant differences in their effects on improved muscle spasm, limitation of motion, or limitation of daily activities. Contraindications
There are few contraindications to methocarbamol. They include:

Hypersensitivity to methocarbamol or to any of the injection components. For the injectable form, suspected kidney failure or renal pathology, due to large content of polyethylene glycol 300 that can increase pre-existing acidosis and urea retention. Side effects
Methocarbamol is a centrally acting skeletal muscle relaxant that has significant adverse effects, especially on the central nervous system.Potential side effects of methocarbamol include:

Most commonly drowsiness, blurred vision, headache, nausea, and skin rash. Possible clumsiness (ataxia), upset stomach, flushing, mood changes, trouble urinating, itchiness, and fever. Both tachycardia (fast heart rate) and bradycardia (slow heart rate) have been reported. Hypersensitivity reactions and anaphylatic reactions are also reported. May cause respiratory depression when combined with benzodiazepines, barbiturates, codeine, or other muscle relaxants.
Marketing
Methocarbamol without other ingredients is sold under the brand name Robaxin in the U.K., U.S., Canada and South Africa; it is marketed as Lumirelax in France, Ortoton in Germany and many other names worldwide. In combination with other active ingredients it is sold under other names: with acetaminophen (paracetamol), under trade names Robaxacet and Tylenol Body Pain Night; with ibuprofen as Robax Platinum; with acetylsalicylic acid as Robaxisal in the U.S. and Canada. However, in Spain the tradename Robaxisal is used for the paracetamol combination instead of Robaxacet. These combinations are also available from independent manufacturers under generic names. Research
Although opioids are a typically first line in treatment of severe pain, several trials suggest that methocarbamol may improve recovery and decrease hospital length of stay in those with muscles spasms associated with rib fractures. However, methocarbamol was less useful in the treatment of acute traumatic pain in general.Long-term studies evaluating the risk of development of cancer in using methocarbamol have not been performed. There are currently no studies evaluating the effect of methocarbamol on mutagenesis or fertility.The safety and efficacy of methocarbamol has not been established in pediatric individuals below the age of 16 except in tetanus. References
External links
"Methocarbamol". Drug Information Portal. U.S. National Library of Medicine.