Co-amilozide (BAN) is a non-proprietary combination of amiloride and hydrochlorothiazide. Co-amilozide is used in the treatment of hypertension and congestive heart failure with the tendency of the thiazide to cause low potassium levels (hypokalaemia) offset by the potassium-sparing effects of amiloride. Formulation
Two strengths of co-amilozide are currently available in the UK:
2.5 mg amiloride and 25 mg hydrochlorothiazide, BAN of Co-amilozide 2.5/25 (brand name Moduret 25)
5 mg amiloride and 50 mg hydrochlorothiazide, BAN of Co-amilozide 5/50 (brand name Moduretic)In North America:

Moduretic (U.S., Canada)
Moduretic 5-50 (U.S., Canada)
Novamilor (Canada)

Side effects
The most common side effect is headache (about 8% of people taking it) and nausea, loss of appetite, weakness, rash and dizziness (each about 3%).Common side effects (1/10 - 1/100) include:
General: weakness, fatigue, loss of appetite, headache, dizziness. Circulatory system: arrhythmia. Gastrointestinal: nausea, diarrhea, abdominal pain. Skin: exanthema, itching. Respiratory system: shortness of breath, cough. Metabolic: elevated blood sugar in diabetic patients, elevated uric acid levels in the blood. Musculoskeletal: pain in the limbs. == References ==
"A rise in reported cases occurred in the early 2000s: eight deaths from the syndrome in California in 2002 after three successive years of four deaths per year, and Schlieverts study found cases in part of Minnesota more than tripled from 2000 to 2003. Schlievert considers earlier onset of menstruation to be a cause of the rise; others, such as Philip M. Tierno and Bruce A. Hanna, blame new high-absorbency tampons introduced in 1999 and manufacturers discontinuing warnings not to leave tampons in overnight.TSS is more common during the winter and spring and occurs most often in the young and old.Toxic shock syndrome is commonly known to be an issue for females who menstruate. TSS although can occur in people of all ages and genders. Around fifty percent of Toxic Shock Syndrome cases are in non menstruating cases. TSS in these cases can be caused by skin wounds, surgical sites, nasal packing, and burns. History
Initial description
The term "toxic shock syndrome" was first used in 1978 by a Denver pediatrician, James K. Todd, to describe the staphylococcal illness in three boys and four girls aged 8–17 years. Even though S. aureus was isolated from mucosal sites in the patients, bacteria could not be isolated from the blood, cerebrospinal fluid, or urine, raising suspicion that a toxin was involved.