Acrogeria (Gottrons syndrome) is a skin condition characterized by premature aging, typically in the form of unusually fragile, thin skin on the hands and feet (distal extremities). The prefix "acro" stems from the Greek  akros which alludes to "extremity, tip" while the suffix "geria" comes from the Greek gerôn which means "elder".This is one of the classic congenital premature aging syndromes, occurring early in life, others being pangeria (Werners syndrome) and progeria (Hutchinson–Gilfords syndrome), and was characterized in 1940. Acrogeria was originally described by Gottron in 1941, when he noticed premature cutaneous aging localized on the hands and feet in two brothers. The problem had been present since birth.Onset is often in early childhood, it progresses over the next few years and then remains stable over time with morphology, colour and site remaining constant. A bruising tendency has been observed. Mutations in the COL3A1 gene, located at chromosome 2q31–q32, have been reported in varied phenotypes, including acrogeria and vascular rupture in Ehlers-Danlos syndrome (more especially type IV). See also
Hutchinson–Gilford syndrome
List of cutaneous conditions

References
External links
Familial acrogeria in a brother and sister
Accessory breasts, also known as polymastia, supernumerary breasts, or mammae erraticae, is the condition of having an additional breast. Extra breasts may appear with or without nipples or areolae. It is a condition and a form of atavism which is most prevalent in male humans, and often goes untreated as it is mostly harmless. In recent years, many affected women have had a plastic surgery operation to remove the additional breasts, for purely aesthetic reasons. A related condition, in which extra nipples form, is called "supernumerary nipple" or "polythelia". Presentation
In some cases, the accessory breast may not be visible at the surface. In these cases, it may be possible to distinguish their appearance from normal breast tissue with MRI. In other cases, accessory breasts have been known to lactate, as illustrated in a drawing showing a child nursing at ectopic breast tissue on the lateral thigh. There is some evidence that the condition may be more common in Native American populations. Cause
Polymastia typically occurs in the womb during the development. During normal development, breast tissue will develop along the milk line, and additional tissue will disintegrate and be absorbed into the body. Polymastia occurs when the additional tissue does not disintegrate before birth. This condition can be inherited. See also
Artemis § As the Lady of Ephesus (fertility goddess with many breasts)
Fleischers syndrome

References

A Paper on the Appearance of Multiple Mammaries in Humans, R. Eghardt, Oxford University Press (1923)
Weird Diseases, B. Hargreaves and M. Wallette, Emu Publishing (2007)


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