Unsuccessfully attacked Julius Caesar three times at Alexandria. Pothinus (1st century BCE): regent for pharaoh Ptolemy XII. First millennium CE
Sporus (died 69): an attractive Roman boy who was castrated by, and later married to, Emperor Nero. Unidentified "Ethiopian eunuch" (1st century AD), from the Kingdom of Kush in modern-day Sudan, described in the Acts of the Apostles (chapter 8). Philip the Evangelist, one of the original seven deacons, is directed by the Holy Spirit to catch up to the eunuchs chariot and hears him reading from the Book of Isaiah (chapter 53). Philip explained that the section prophesies Jesus crucifixion, which Philip described to the eunuch. The eunuch was baptized shortly thereafter. Halotus (c. 20–30 CE – c. 70–80 CE), servant to the Roman Emperor Claudius and suspected of poisoning him. Cai Lun (c. 50–62–121): Former attribution to Lun as the inventor of paper has been rescinded following discovery of many earlier manuscripts written on paper. It is now highly questionable if he was directly involved in making paper. Zhang Rang: head of the infamous "10 Changshi" (ten attendants) of the Eastern Han dynasty. Huang Hao: eunuch in the state of Shu; also appears in the Romance of the Three Kingdoms. Cen Hun (died 280): eunuch in the state of Wu during the Three Kingdoms Period. Origen (c. 185–c.
Tinidazole is a drug used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class.It is on the World Health Organizations List of Essential Medicines.Tinidazole is marketed by Mission Pharmacal under the brand name Tindamax, by Pfizer under the names Fasigyn and Simplotan, and in some Asian countries as Sporinex. Uses
Tinidazole may be a therapeutic alternative in the setting of metronidazole intolerance. Tinidazole is used to treat Helicobacter pylori, Amoebic dysentery, Giardia and Trichomonas vaginalis. Side effects
Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath. Half-life
Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours. References
External links
MedlinePlus Drug Information: Tinidazole
Drug Bank Facts on Tinidazole