Trichophyton is a genus of fungi, which includes the parasitic varieties that cause tinea, including athletes foot, ringworm, jock itch, and similar  infections of the nail, beard, skin and scalp. Trichophyton fungi are molds characterized by the development of both smooth-walled macro- and microconidia. Macroconidia are mostly borne laterally directly on the hyphae or on short pedicels, and are thin- or thick-walled, clavate to fusiform, and range from 4 to 8 by 8 to 50 μm in size. Macroconidia are few or absent in many species. Microconidia are spherical, pyriform to clavate or of irregular shape, and range from 2 to 3 by 2 to 4 μm in size. Species and their habitat preference
According to current classification, the genus includes anthropophilic and zoophilic species. Anthropophilic fungi prefer to infect humans. Zoophilic fungi prefer to infect animals other than humans. Humans and animals are natural reservoirs for parasitic or dermatophytic fungi. Other accepted species;

Mating and meiosis
Trichophyton mentagrophytes (Family Arthrodermataceae, Genus Trichophyton) is capable of both mating and meiosis. Effect on humans
The anthropophilic varieties cause forms of dermatophytosis, that is, fungal infection of the skin. They are keratinophilic: they feed on the keratin in nails, hair, and dead skin. Trichophyton concentricum causes "Malabar itch", a skin infection consisting of an eruption of a number of concentric rings of overlapping scales forming papulosquamous patches.Trichophyton rubrum and Trichophyton interdigitale cause athletes foot (tinea pedis), toenail fungal infections (a.k.a. tinea unguium, a.k.a. onychomycosis), crotch itch (a.k.a.
Emedastine (trade name Emadine) is a second generation antihistamine used in eye drops to alleviate the symptoms of allergic conjunctivitis. It acts as a H1 receptor antagonist. It works by blocking the action of histamine that causes allergic symptoms. It is used in form of the difumarate. The emedastine difumarate is a white, crystalline, water-soluble fine powder. Emedastine eye drops is usually applied twice a day to the affected eye. When the patients with allergic conjunctivitis were treated with 0.05% emedastine difumarate ophthalmic solution for six weeks, the signs and symptoms such as redness, itching and swelling of the eyes were relieved. Emedastine appears to be devoid of effects on adrenergic, dopaminergic and serotonin receptors. This drug was developed by Alcon, which is global medical company specializing in eye care products. Pharmacodynamics
Emedastine is significantly selective to H1 histamine receptors (Ki = 1.3 nM), whereas its affinities for other histamine receptors were low (H2: Ki = 49067 nM and H3: Ki = 12430 nM) ub in vitro study. Topical ocular administration of emedastine inhibits histamine-stimulated vascular permeability in the conjunctiva as a concentration-dependent manner in in vitro study. Pharmacokinetics
The human oral bioavailability is approximately 50% and maximum plasma concentration was achieved within 1–2 hours after dosing. Emedastine is mainly metabolized by the liver. There are two primary metabolites: 5-hydroxyemedastine and 6-hydroxyemedastine. They are excreted in the urine as both free and conjugated forms. The 5-oxoanalogs of 5-hydroxyemedastine, 6-hydroxyemedastine and the N-oxide are also formed as minor metabolites.