If the neonatal IgG antibody titres are significantly higher than the mothers, then congenital syphilis can be confirmed. Specific IgM in the infant is another method of confirmation. CSF pleocytosis, raised CSF protein level and positive CSF serology suggest neurosyphilis. Treatment
If a pregnant mother is identified as being infected with syphilis, treatment can effectively prevent congenital syphilis from developing in the fetus, especially if she is treated before the sixteenth week of pregnancy. The fetus is at greatest risk of contracting syphilis when the mother is in the early stages of infection, but the disease can be passed at any point during pregnancy, even during delivery (if the child had not already contracted it). A woman in the secondary stage of syphilis decreases her fetuss risk of developing congenital syphilis by 98% if she receives treatment before the last month of pregnancy. An affected child can be treated using antibiotics much like an adult; however, any developmental symptoms are likely to be permanent.Kassowitzs law is an empirical observation used in context of congenital syphilis stating that the greater the duration between the infection of the mother and conception, the better the outcome for the infant. Features of a better outcome include less chance of stillbirth and of developing congenital syphilis.The Centers for Disease Control and Prevention recommends treating symptomatic or babies born to an infected mother with unknown treatment status with procaine penicillin G, 50,000 U/kg dose IM a day in a single dose for 10 days.
By definition, it occurs in children at or greater than 2 years of age who acquired the infection trans-placentally.Symptoms include:
Blunted upper incisor teeth known as Hutchinsons teeth
Deafness from auditory nerve disease
Frontal bossing (prominence of the brow ridge)
Hard palate defect
Inflammation of the cornea known as interstitial keratitis
Protruding mandible
Saber shins
Saddle nose (collapse of the bony part of nose)
Short maxillae
Swollen kneesA frequently-found group of symptoms is Hutchinsons triad, which consists of Hutchinsons teeth (notched incisors), keratitis and deafness and occurs in 63% of cases.Treatment (with penicillin) before the development of late symptoms is essential. Signs and symptoms
Abnormal x-rays
Anemia
Cerebral palsy
Du Bois sign, narrowing of the little finger
Enlarged liver
Enlarged spleen
Frontal bossing
Sensorineural hearing loss
Higouménakis sign, enlargement of the sternal end of clavicle in late congenital syphilis
Hutchinsons triad, a set of symptoms consisting of deafness, Hutchinsons teeth (centrally notched, widely spaced peg-shaped upper central incisors), and interstitial keratitis (IK), an inflammation of the cornea which can lead to corneal scarring and potential blindness
Hydrocephalus
Jaundice
Lymph node enlargement
Mulberry molars (permanent first molars with multiple poorly developed cusps)
Musculoskeletal deformities
Petechiae
Poorly developed maxillae
Pseudoparalysis
Rhagades, linear scars at the angles of the mouth and nose result from bacterial infection of skin lesions
Snuffles, aka "syphilitic rhinitis", which appears similar to the rhinitis of the common cold, except it is more severe, lasts longer, often involves bloody rhinorrhea, and is often associated with laryngitis
Sabre shins
Skin rashDeath from congenital syphilis is usually due to bleeding into the lungs. Diagnosis
Serological testing is carried out on the mother and the infant.