Other
The muscles that control breathing and limb movements can also be affected; rarely do these present as the first symptoms of MG, but develop over months to years. In a myasthenic crisis, a paralysis of the respiratory muscles occurs, necessitating assisted ventilation to sustain life. Crises may be triggered by various biological stressors such as infection, fever, an adverse reaction to medication, or emotional stress. Pathophysiology
MG is an autoimmune synaptopathy. The disorder occurs when the immune system malfunctions and generates antibodies that attack the bodys tissues. The antibodies in MG attack a normal human protein, the nicotinic acetylcholine receptor, or a related protein called MuSK, a muscle-specific kinase. Other, less frequent antibodies are found against LRP4, agrin, and titin proteins.Human leukocyte antigen haplotypes are associated with increased susceptibility to myasthenia gravis and other autoimmune disorders. Relatives of people with myasthenia gravis have a higher percentage of other immune disorders.The thymus gland cells form part of the bodys immune system. In those with myasthenia gravis, the thymus gland is large and abnormal. It sometimes contains clusters of immune cells that indicate lymphoid hyperplasia, and the thymus gland may give wrong instructions to immune cells. In pregnancy
For women who are pregnant and already have MG, in a third of cases, they have been known to experience an exacerbation of their symptoms, and in those cases, it usually occurs in the first trimester of pregnancy. Signs and symptoms in pregnant mothers tend to improve during the second and third trimesters. Complete remission can occur in some mothers.
Lichen myxedematosus is a group of cutaneous disorders considered mucinoses. : 183   Conditions included in this group are:: 183 
Generalized lichen myxedematosus
Localized lichen myxedematosusDiscrete papular lichen myxedematosus
Acral persistent papular mucinosis
Self-healing papular mucinosisSelf-healing juvenile cutaneous mucinosisPapular mucinosis of infancy
Atypical lichen myxedematosus
Atypical tuberous myxedema

See also
List of cutaneous conditions

References


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