Other significant issues involve the difficulty in crossing the blood–brain barrier, as well as the great expense, as each unit of cord blood costs $25,000, and adult recipients need many units. Gene therapy
On 10 February 2022, the first ever gene therapy was announced, it uses an adeno-associated virus (AAV) to deliver the correct instruction for the HEXA gene on brain cells which causes the disease. Only two children were part of a compassionate trial presenting improvements over the natural course of the disease and no vector-related adverse events. References
External links

GeneReviews/NCBI/NIH/UW entry on hexosaminidase A deficiency, Tay–Sachs disease
NINDS Tay–Sachs Disease Information Page
Tay–Sachs disease at NLM Genetics Home Reference
Tay–Sachs on NCBI
In general, these trucks are composed of a chassis, a motor, a transmission, a cabin, an area for the placement of the load and the equipment, axles of transmission, suspensions, direction, tires, electrical, pneumatic, hydraulic, engine cooling systems, and brakes. They can be operated with a gasoline engine or with a diesel engine, there are four-wheel drive (4x4) vehicles, six wheeled (6x6), eight wheeled (8x8), ten wheeled (10x10) and even twelve wheeled vehicles (12x12). Types of military vehicles
Land combat and military transport vehicles include:

See also
Military transport (equipment) not primarily used on land:
Military aircraft
Military spacecraft
Naval ships
Warships
Camouflage
List of military vehicles


== References ==