In a cohort of 35 patients with this type of pemphigoid (diagnosed with immunoprecipitation), 10 (29 percent) developed solid organ malignancies, 7 of which were diagnosed within 14 months after a diagnosis of MMP. Occurrences of non-Hodgkin lymphoma and cutaneous T cell lymphoma have also been reported in individual patients with anti-laminin 332 MMP. The pathophysiologic relationship of this subtype of MMP to cancer is unknown. However, expression of laminin 332 has been detected in malignant cells, and laminin 332 appears to be capable of promoting tumor cell growth, invasion, and metastasis.The clinical manifestations of MMP in patients with laminin 332 antibodies are similar to the features of MMP with other antibody profiles. Therefore, clinical examination cannot reliably distinguish anti-laminin 332 MMP from other forms of MMP. Additional studies are necessary to confirm the findings of a retrospective study of 154 patients with MPP that associated the detection of laminin 332 antibodies via a novel enzyme-linked immunosorbent assay (ELISA) with a greater likelihood for severe disease. Since diagnostic laboratory testing for laminin 332 antibodies is not commercially available, suspicion for laminin 332 primarily is based upon immunofluorescence microscopy findings. Although not exclusive to laminin 332 MPP, the detection of antibodies bound to the dermal side of basement membrane zone-split (salt-split) skin suggests the possibility of this diagnosis.
Microvasculitis refers to a range of diseases or presentations associated with a disease, where there is inflammation of small blood vessels:

Kawasaki disease
Susac syndrome

Nerve microvasculitis
Non-systemic vasculitic neuropathy (NSVN)
Hepatitis C-related cryoglobulinemia neuropathy (CRYOVASC)
Hepatitis B-associated PAN
Diabetic lumbosacral radiculoplexus neuropathy (DLRPN)
Non-diabetic lumbosacral radiculoplexus neuropathy (LRPN)
Diabetic cervical-radiculoplexus neuropathy (DCRPN)
Diabetic Cranio-Cervico-Radiculoplexus Neuropathy
Diabetic Cervical Neuropathy


== References ==