They emerge from the anus, and while moving on the skin near the anus, the female pinworms deposit eggs either through (1) contracting and expelling the eggs, (2) dying and then disintegrating, or (3) bodily rupture due to the host scratching the worm. After depositing the eggs, the female becomes opaque and dies. The reason the female emerges from the anus is to obtain the oxygen necessary for the maturation of the eggs. Diagnosis
Diagnosis relies on finding the eggs or the adult pinworms. Individual eggs are invisible to the naked eye, but they can be seen using a low-power microscope. On the other hand, the light-yellowish thread-like adult pinworms are clearly visually detectable, usually during the night when they move near the anus, or on toilet paper. Shining a flashlight on the infected individuals anus about one hour after they fall asleep is one form of detection and may show worms crawling out of the anus. Another form of detection is the use of transparent adhesive tape (e.g. Scotch Tape) applied on the anal area which will pick up deposited eggs, and diagnosis can be made by examining the tape with a microscope. This test is most successful if done every morning for several days, because the females do not lay eggs every day, and the number of eggs varies.
History
Brinzolamide/brimonidine was approved for medical use in the United States in April 2013, and in the European Union in July 2014. References
Further reading
Li T, Lindsley K, Rouse B, Hong H, Shi Q, Friedman DS, Wormald R, Dickersin K (January 2016). "Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis". Ophthalmology. 123 (1): 129–40. doi:10.1016/j.ophtha.2015.09.005. PMC 4695285. PMID 26526633. Lusthaus JA, Goldberg I (September 2017). "Brimonidine and brinzolamide for treating glaucoma and ocular hypertension; a safety evaluation". Expert Opin Drug Saf. 16 (9): 1071–1078. doi:10.1080/14740338.2017.1346083. PMID 28656780. S2CID 205825340. External links
"Brinzolamide". Drug Information Portal. U.S. National Library of Medicine. "Brimonidine". Drug Information Portal. U.S. National Library of Medicine. "Brimonidine tartrate". Drug Information Portal. U.S. National Library of Medicine.