VPA also has a wide range of side effects, like high-frequency tremor, altered mental status, increased appetite and weight gain, pancreatitis, and hepatic failure, thrombocytopenia, teratogenesis during pregnancy, although serious side effects are rare and usually dose-dependent. Usual maintenance dose in children is 20–30 mg/kg/day. Lamotrigine (LTG) could be can be used as alternative add-on treatment for CAE along with VPA and ETX. Other possible treatments in the rare cases of pharmacoresistant include levetiracetam, clobazam, topiramate, zonisamide. Epidemiology
The occurrence of absence seizures varies from 0.7 to 4.6/100,000 in the overall population and from 6 to 8/100,000 in children up to 15 years old. There is some evidence showing that girls are more frequently affected by CAE than boys. See also
Generalized epilepsy with febrile seizures plus
Calcium channel
Spike and Wave

References
Perez-Reyes E (2006). "Molecular characterization of T-type calcium channels". Cell Calcium. 40 (2): 89–96. doi:10.1016/j.ceca.2006.04.012. PMID 16759699. Footnotes


== External links ==
Methyclothiazide is a thiazide diuretic. == References ==