The kidneys regulate the serum magnesium. About 2400 mg of magnesium passes through the kidneys daily, of which 5% (120 mg) is excreted through urine. The loop of Henle is the major site for magnesium homeostasis, and 60% is reabsorbed. Magnesium homeostasis comprises three systems: kidney, small intestine, and bone. In the acute phase of magnesium deficiency there is an increase in absorption in the distal small intestine and tubular resorption in the kidneys. When this condition persists, serum magnesium drops and is corrected with magnesium from bone tissue. The level of intracellular magnesium is controlled through the reservoir in bone tissue. Diagnosis
Magnesium deficiency is not easy to directly measure. Typically the diagnosis is based on finding low blood magnesium levels (hypomagnesemia). Specifically by finding a plasma magnesium concentration of less than 0.6 mmol/L (1.46 mg/dL). Severe disease generally has a level of less than 0.50 mmol/L (1.25 mg/dL).Magnesium deficiency (or depletion) refers to low total body levels of magnesium which is usually determined by finding low blood levels (hypomagnesemia). Hypomagnesemia refers only to blood levels of magnesium. Either of magnesium deficiency and hypomagnesemia can be present without the other. Electrocardiogram
The electrocardiogram (ECG) change may show a tachycardia with a prolonged QT interval. Other changes may include prolonged PR interval, ST segment depression, flipped T waves, and long QRS duration. Treatments
Treatment of hypomagnesemia depends on the degree of deficiency and the clinical effects.
Ecthyma( ec·​thy·​ma | \ ek-ˈthī-mə )is a variation of impetigo, presenting at a deeper level of tissue.It is usually associated with Group A (beta-hemolytic) Streptococcus (abbreviated GAS). See also
Ecthyma gangrenosum

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