Paradoxical reactions
Although unusual, the following paradoxical reactions have been shown to occur:

Aggression
Mania, agitation, hyperactivity, and restlessness
Rage, hostility
Twitches and tremor

Food and drug interactions
Alprazolam is primarily metabolized via CYP3A4. Combining CYP3A4 inhibitors such as cimetidine, erythromycin, norfluoxetine, fluvoxamine, itraconazole, ketoconazole, nefazodone, propoxyphene, and ritonavir delay the hepatic clearance of alprazolam, which may result in its accumulation and increased severity of its side effects.Imipramine and desipramine have been reported to increase an average of 31% and 20% respectively by the concomitant administration of alprazolam tablets. Combined oral contraceptive pills reduce the clearance of alprazolam, which may lead to increased plasma levels of alprazolam and accumulation.Alcohol is one of the most common interactions; alcohol and alprazolam taken in combination have a synergistic effect on one another, which can cause severe sedation, behavioral changes, and intoxication. The more alcohol and alprazolam taken, the worse the interaction. Combination of alprazolam with the herb kava can result in the development of a semi-comatose state. Plants in the genus Hypericum (including St. Johns wort) conversely can lower the plasma levels of alprazolam and reduce its therapeutic effect. Pregnancy and breastfeeding
Benzodiazepines cross the placenta, enter the fetus, and are also excreted in breast milk. Chronic administration of diazepam, another benzodiazepine, to nursing mothers has been reported to cause their infants to become lethargic and to lose weight.The use of alprazolam during pregnancy is associated with congenital abnormalities, and use in the last trimester may cause fetal drug dependence and withdrawal symptoms in the post-natal period as well as neonatal flaccidity and respiratory problems.
Then the cannulas and the catheter are placed, cardiopulmonary bypass is commenced (venous deoxygenated blood arriving to the heart is forwarded to the CBP machine to get oxygenated and delivered to aorta to keep rest of the body saturated, and often cooled to 32 - 34 degrees celsius in order to slow down the metabolism and minimize as much as possible the demand for oxygen. A clamp is placed on the Aorta between the cardioplegic catheter and aortic cannula, so the cardioplegic solution that the flow is controlled by the surgeon that clamps Aorta. Within minutes, heart stops beating. Anastomosis (grafting)With the heart still, the tip of the heart is taken out of pericardium, so the native arteries lying in the posterior side of the heart are accessible. Usually, distal anastomosis are constructed first (first to right coronary system, then to the circumflex) and then the sequential anastomosis if necessary. Surgeons check the anastomosis for patency or leaking and if everything is as it should be, surgeons insert the graft within the pericardium, sometimes attached to the cardioplegic catheter. The anastomosis of LIMA to LAD is usually the last one of the distal anastomoses to be constructed, while it is being constructed the rewarming process starts (by the CPB).. After the anastomosis is completed and checked for leaks, the proximal anastomoses of the conduits, if any, are next.