Erectile dysfunction and hypogonadism, resulting in decreased libido, amenorrhea
Congestive heart failure, abnormal heart rhythms, or pericarditis
Arthritis of the hands (especially the second and third metacarpophalangeal joints), but also the knee and shoulder joints
Weight lossLess common findings including:

Memory loss
Hair loss
Splenomegaly
adrenal insufficiency
Deafness
Dyskinesias, including Parkinsonian symptoms
Dysfunction of certain endocrine organs:
Parathyroid gland (leading to hypocalcaemia)
Pituitary gland: secondary hypothyroidism, secondary hypogonadism
Adrenal gland
An increased susceptibility to certain infectious diseases caused by siderophilic microorganisms:
Vibrio vulnificus infections from eating seafood or wound infection
Listeria monocytogenes
Yersinia enterocolica
Salmonella enterica (serotype Typhymurium)
Klebsiella pneumoniae
Escherichia coli
Rhizopus arrhizus
Mucor species
Aspergillus fumigatus
Cytomegalovirus
Hepatitis B virus
Hepatitis C virusIn the hereditary hemochromatosis (HH or HHC), males are usually diagnosed after their forties and fifties, and women some decades later, during menopause. The severity of clinical disease varies considerably. Some evidence suggests that hereditary haemochromatosis patients affected with other liver ailments such as hepatitis or alcoholic liver disease have worse liver disease than those with either condition alone. Also, juvenile form of primary haemochromatosis (Hemochromatosis type 2) present in childhood with the same consequences of iron overload. End-organ damage
Iron is stored in the liver, pancreas and heart. Long-term effects of haemochromatosis on these organs can be serious, even fatal when untreated.Since the liver is a primary storage area for iron and naturally accumulates excess iron over time, it is likely to be damaged by iron overload. Toxins may accumulate in the blood and eventually affect mental functioning due to increased risk of hepatic encephalopathy. Together, they can increase the risk of liver cancer to one in three persons.
If excess iron in the heart interferes with its ability to circulate enough blood, a number of problems can occur, including (potentially fatal) congestive heart failure. The condition may be reversible when haemochromatosis is treated and excess iron stores are reduced. Arrhythmia or abnormal heart rhythm can cause heart palpitations, chest pain, and light-headedness, and is occasionally life-threatening. This condition can often be reversed with treatment.The pancreas, which also stores iron, is very important in the bodys mechanisms for sugar metabolism. Diabetes affects the way the body uses blood sugar (glucose), and diabetes is, in turn, the leading cause of new blindness in adults and may be involved in kidney failure.Haemochromatosis may lead to cirrhosis and its complications, including bleeding from dilated veins in the esophagus (esophageal varices) and stomach (gastric varices) and severe fluid retention in the abdomen (ascites). Severity of periodontal disease is associated with high transferrin saturation in haemochromatosis patients. Genetics
The regulation of dietary iron absorption is complex and understanding is incomplete. One of the better-characterized genes responsible for hereditary haemochromatosis is HFE on chromosome 6, which codes for hepcidin, a protein that participates in the regulation of iron absorption.