Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and carboplatin. On the other hand, therapies with low risk of gonadotoxicity include plant derivatives such as vincristine and vinblastine, antibiotics such as bleomycin and dactinomycin and antimetabolites such as methotrexate, mercaptopurine and 5-fluorouracil.Female infertility by chemotherapy appears to be secondary to premature ovarian failure by loss of primordial follicles. This loss is not necessarily a direct effect of the chemotherapeutic agents, but could be due to an increased rate of growth initiation to replace damaged developing follicles. Antral follicle count decreases after three series of chemotherapy, whereas follicle stimulating hormone (FSH) reaches menopausal levels after four series. Other hormonal changes in chemotherapy include decrease in inhibin B and anti-Müllerian hormone levels.Women may choose between several methods of fertility preservation prior to chemotherapy, including cryopreservation of ovarian tissue, oocytes or embryos. Immune infertility
Antisperm antibodies (ASA) have been considered as infertility cause in around 10–30% of infertile couples. ASA production are directed against surface antigens on sperm, which can interfere with sperm motility and transport through the female reproductive tract, inhibiting capacitation and acrosome reaction, impaired fertilization, influence on the implantation process, and impaired growth and development of the embryo. Factors contributing to the formation of antisperm antibodies in women are disturbance of normal immunoregulatory mechanisms, infection, violation of the integrity of the mucous membranes, accidental rape and unprotected oral or anal sex. Other acquired factors
Adhesions secondary to surgery in the peritoneal cavity is the leading cause of acquired infertility.
Maceration  may refer to:

Maceration (food), in food preparation
Maceration (wine), a step in wine-making
Carbonic maceration, a wine-making technique
Maceration (sewage), in sewage treatment
Maceration (bone), a method of preparing bones
Acid maceration, the use of an acid to extract micro-fossils from rock
Maceration, in chemistry, the preparation of an extract by solvent extraction
Maceration, in biology, the mechanical breakdown of ingested food into chyme
Skin maceration, in dermatology, the softening and whitening of skin that is kept constantly wet
Maceration, in poultry farming, a method of chick culling