Lack of oxygen response may indicate other modalities such as heated humidified high-flow therapy, continuous positive airway pressure or (if severe) endotracheal intubation and mechanical ventilation. .Type 2 respiratory failure often requires non-invasive ventilation (NIV) unless medical therapy can improve the situation. Mechanical ventilation is sometimes indicated immediately or otherwise if NIV fails. Respiratory stimulants such as doxapram are now rarely used.There is tentative evidence that in those with respiratory failure identified before arrival in hospital, continuous positive airway pressure can be helpful when started before conveying to hospital. See also
Ventilation/perfusion ratio
Pulmonary shunt

References
External links
MedlinePlus: Respiratory Failure
Treatment
Up until the advent of modern therapies, favus was widespread worldwide; prior to Schönleins recognition of it as a fungal disease, it was frequently confused with Hansens disease, better known as leprosy, and affected Europeans were sometimes committed to leprosaria. Today, due to this species high susceptibility to the antifungal drug griseofulvin, it has been eliminated from most parts of the world except rural central Asia and scattered rural areas of Africa. It is mainly a disease connected to demographic poverty and isolation, but is so readily treatable that it is among the diseases most likely to be eliminated by modern medicine. References

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