Margaret Sullavan, American stage and film actress, suffered from the congenital hearing defect otosclerosis that worsened as she aged, making her more and more hard of hearing. Howard Hughes the pioneering American aviator, engineer, industrialist, and film producer also suffered from otosclerosis. Frankie Valli, lead singer of The Four Seasons, suffered from it in the late 1960s and early 1970s, forcing him to "sing from memory" in the latter part of the 70s (surgery restored most of his hearing by 1980). Pittsburgh Penguins forward Steve Downie suffers from otosclerosis. The British queen Alexandra of Denmark suffered from it, leading to her social isolation; Queen Alexandras biographer, Georgina Battiscombe, was able to have "some understanding of Alexandras predicament" because she too had otosclerosis. Adam Savage, co-host of MythBusters, uses a hearing aid due to otosclerosis. Sir John Cornforth, Australian-British Nobel Prize in Chemistry laureate

References
External links
NIH/Medline
In case of emergency, plasmapheresis may be tried
In PAN associated with a hepatitis virus: combination therapy of prednisone along with a virustatic, such as lamivudine (Hepatitis B) or interferon-alpha and ribavirin (Hepatitis C)

Granulomatosis with polyangiitis (GPA)
Symptoms
Men are affected twice as often as women
Compression of structures surrounding the nose and paranasal sinuses
Diabetes insipidus
Abnormal protrusion of the eyeball(s)
Nonseptic meningitis
Affection of the lung and kidney due to destruction of the arteries and veins
Ischemic stroke, hemorrhages, or encephalopathy with possible seizures

Diagnostic Criteria
Two or more of the following four criteria are required:

Necrotizing ulcerating inflammation of nose, sinuses, mouth or pharynx
Irregular lung infiltrates
Nephritis
Granulomatous vascular and perivascular inflammation

Treatment Therapy
Corticosteroids (e.g., Prednisolone)
Cyclophosphamide
Azathioprine
Mycophenolate mofetil

References


== External links ==