18q deletion syndrome
Acrodermatitis enteropathica
Acrogeria (Gottron syndrome)
Acrokeratosis verruciformis (acrokeratosis verruciformis of Hopf)
Adams–Oliver syndrome
Adducted thumbs syndrome
Albrights hereditary osteodystrophy
Angelman syndrome
Apert syndrome (acrocephalosyndactyly)
Arthrogryposis–renal dysfunction–cholestasis syndrome
Ataxia telangiectasia (Louis–Bar syndrome)
Atrichia with papular lesions (papular atrichia)
Atrophodermia vermiculata (acne vermoulante, acne vermoulanti, atrophoderma reticulata symmetrica faciei, atrophoderma reticulatum, atrophoderma vermiculata, atrophoderma vermiculatum, atrophodermia reticulata symmetrica faciei, atrophodermia ulerythematosa, atrophodermie vermiculée des joues avec kératoses folliculaires, folliculitis ulerythema reticulata, folliculitis ulerythematous reticulata, folliculitis ulerythemosa, honeycomb atrophy, ulerythema acneforme, ulerythema acneiforme)
Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy syndrome
Bart syndrome
Bazex–Dupré–Christol syndrome (Bazex syndrome, follicular atrophoderma and basal cell carcinomas)
Beare–Stevenson cutis gyrata syndrome
Bloom syndrome (Bloom–Torre–Machacek syndrome)
Blue rubber bleb nevus syndrome
Brittle hair–intellectual impairment–decreased fertility–short stature syndrome
Cantú syndrome
Cardio-facio-cutaneous syndrome (cardiofaciocutaneous syndrome)
Cartilage–hair hypoplasia (McKusick type metaphyseal chondrodysplasia)
Cerebral dysgenesis–neuropathy–ichthyosis–keratoderma syndrome
Childhood tumor syndrome
Chondrodysplasia punctata
Cicatricial junctional epidermolysis bullosa
Craniosynostosis–anal anomalies–porokeratosis syndrome
Cockayne syndrome
Colobomas of the eye–heart defects–ichthyosiform dermatosis–mental retardation–ear defects syndrome (CHIME syndrome, Zunich neuroectodermal syndrome, Zunich–Kaye syndrome)
Congenital hemidysplasia with ichthyosiform erythroderma and limb defects syndrome (CHILD syndrome)
Conradi–Hünermann syndrome (Conradi–Hünermann–Happle syndrome, Happle syndrome, X-linked dominant chondrodysplasia punctata)
Costello syndrome
Cronkhite–Canada syndrome
Crouzon syndrome
Cutis verticis gyrata
Dariers disease (Darier–White disease, dyskeratosis follicularis, keratosis follicularis) 
DeSanctis–Cacchione syndrome
Disseminated superficial actinic porokeratosis
Disseminated superficial porokeratosis
Dolichol kinase deficiency
Dominant dystrophic epidermolysis bullosa
Dyskeratosis congenita (Zinsser–Cole–Engman syndrome)
Dystrophic epidermolysis bullosa
Ectodermal dysplasia
Ectodermal dysplasia with corkscrew hairs
Ectrodactyly–ectodermal dysplasia–cleft syndrome (EEC syndrome, split hand–split foot–ectodermal dysplasia–cleft syndrome)
Epidermolysis bullosa herpetiformis (Dowling–Meara epidermolysis bullosa simplex)
Epidermolysis bullosa simplex
Epidermolysis bullosa simplex of Ogna
Epidermolysis bullosa simplex with mottled pigmentation
Epidermolysis bullosa simplex with muscular dystrophy
Epidermolytic hyperkeratosis (bullous congenital ichthyosiform erythroderma, bullous ichthyosiform erythroderma)
Erythrokeratodermia with ataxia (Giroux–Barbeau syndrome)
Familial benign chronic pemphigus (familial benign pemphigus, Hailey–Hailey disease)
Fanconi syndrome (familial pancytopenia, familial panmyelophthisis)
Fibrodysplasia ossificans progressiva
Focal dermal hypoplasia (Goltz syndrome)
Follicular atrophoderma
Franceschetti–Klein syndrome (mandibulofacial dysostosis)
Gardners syndrome (familial colorectal polyposis)
Gastrocutaneous syndrome
Generalized atrophic benign epidermolysis bullosa
Generalized epidermolysis bullosa simplex (Koebner variant of generalized epidermolysis bullosa simplex)
Generalized trichoepithelioma
Giant axonal neuropathy with curly hair
Gingival fibromatosis with hypertrichosis
Haber syndrome
Hallerman–Streiff syndrome
Harlequin-type ichthyosis (harlequin baby, harlequin fetus, harlequin ichthyosis, ichthyosis congenita, ichthyosis congenita gravior)
Hay–Wells syndrome (AEC syndrome, ankyloblepharon filiforme adnatum–ectodermal dysplasia–cleft palate syndrome, ankyloblepharon–ectodermal defects–cleft lip and palate syndrome, ankyloblepharon–ectodermal dysplasia–clefting syndrome)
Hereditary sclerosing poikiloderma 
Heterochromia iridum
Holocarboxylase synthetase deficiency
Hypohidrotic ectodermal dysplasia (anhidrotic ectodermal dysplasia, Christ–Siemens–Touraine syndrome)
Hypotrichosis–acro-osteolysis–onychogryphosis–palmoplantar keratoderma–periodontitis syndrome
Hypotrichosis–lymphedema–telangiectasia syndrome
Ichthyosis–brittle hair–impaired intelligence–decreased fertility–short stature syndrome (IBIDS syndrome, sulfur-deficient brittle hair syndrome, Tays syndrome, trichothiodystrophy, trichothiodystrophy with ichthyosis)
Ichthyosis bullosa of Siemens (ichthyosis exfoliativa)
Ichthyosis follicularis (ichthyosis follicularis with alopecia and photophobia syndrome)
Ichthyosis linearis circumflexa
Ichthyosis prematurity syndrome
Ichthyosis vulgaris (autosomal dominant ichthyosis, ichthyosis simplex)
Ichthyosis with confetti
Neonatal ichthyosis–sclerosing cholangitis syndrome (ichthyosis–sclerosing cholangitis syndrome, NISCH syndrome)
Incontinentia pigmenti achromians (hypomelanosis of Ito)
Immune dysfunction–polyendocrinopathy–enteropathy–X-linked syndrome
Jaffe–Campanacci syndrome
Johanson–Blizzard syndrome
Johnson–McMillin syndrome
Joubert syndrome
Junctional epidermolysis bullosa
Junctional epidermolysis bullosa gravis (epidermolysis bullosa letalis, Herlitz disease, Herlitz epidermolysis bullosa, Herlitz syndrome, lethal junctional epidermolysis bullosa)
Junctional epidermolysis bullosa with pyloric atresia
Kabuki syndrome (Kabuki makeup syndrome, Niikawa–Kuroki syndrome)
Keratolytic winter erythema (erythrokeratolysis hiemalis, Oudtshoorn disease, Oudtshoorn skin)
Keratosis follicularis spinulosa decalvans (Siemens-1 syndrome)
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma syndrome
Keratosis pilaris atrophicans faciei (folliculitis rubra, keratosis pilaris rubra atrophicans faciei, lichen pilare, lichen pilaire ou xerodermie pilaire symmetrique de la face, ulerythema ophryogenes, xerodermi pilaire symmetrique de la face)
Keratosis pilaris
Kindler syndrome (acrokeratotic poikiloderma, bullous acrokeratotic poikiloderma of Kindler and Weary, congenital poikiloderma with blisters and keratoses, congenital poikiloderma with bullae and progressive cutaneous atrophy, hereditary acrokeratotic poikiloderma, hyperkeratosis–hyperpigmentation syndrome, Weary–Kindler syndrome)
Klinefelter syndrome
Klippel–Feil syndrome
Lamellar ichthyosis (collodion baby)
Legius syndrome (neurofibromatosis type 1-like syndrome)
Lelis syndrome
Lenz–Majewski syndrome
Leschke syndrome
Lethal acantholytic epidermolysis bullosa
Lhermitte–Duclos disease
Linear and whorled nevoid hypermelanosis (linear nevoid hyperpigmentation, progressive cribriform and zosteriform hyperpigmentation, reticulate and zosteriform hyperpigmentation, reticulate hyperpigmentation of Iijima and Naito and Uyeno, zebra-like hyperpigmentation in whorls and streaks, zebra-line hyperpigmentation)
Linear Darier disease (acantholytic dyskeratotic epidermal nevus)
Linear porokeratosis
Localized epidermolysis bullosa simplex (Weber–Cockayne syndrome, Weber–Cockayne variant of generalized epidermolysis bullosa simplex)
Mandibuloacral dysplasia
Marinesco–Sjögren syndrome
McCune–Albright syndrome
McCusick syndrome
Metageria
Microphthalmia–dermal aplasia–sclerocornea syndrome
Mitis junctional epidermolysis bullosa (nonlethal junctional epidermolysis bullosa)
Mitochondrial myopathy–encephalopathy–lactic acidosis–stroke syndrome
Multiple lentigines syndrome (cardiocutaneous syndrome, Gorlin syndrome II, lentiginosis profusa syndrome, LEOPARD syndrome, progressive cardiomyopathic lentiginosis)
Multiple pterygium syndrome
Multiple sulfatase deficiency (Austin disease, mucosulfatidosis)
Naegeli–Franceschetti–Jadassohn syndrome (chromatophore nevus of Naegeli)
Netherton syndrome
Neurofibromatosis type 1 (von Recklinghausens disease) 
Neurofibromatosis type 3 (neurofibromatosis mixed type)
Neurofibromatosis type 4 (neurofibromatosis variant type)
Neutral lipid storage disease (Dorfman–Chanarin syndrome)
Nonbullous congenital ichthyosiform erythroderma (congenital ichthyosiform erythroderma)
Noonan syndrome
Oculocerebrocutaneous syndrome (Delleman–Oorthuys syndrome)
Oculodentodigital dysplasia
Odonto–Tricho–Ungual–Digital–Palmar syndrome
Oliver–McFarlane syndrome
Orofaciodigital syndrome
Pachydermoperiostosis (idiopathic hypertrophic osteoathorpathy, Touraine–Solente–Gole syndrome)
Peeling skin syndrome (acral peeling skin syndrome, continual peeling skin syndrome, familial continual skin peeling, idiopathic deciduous skin, keratolysis exfoliativa congenita)
Pfeiffer syndrome
Photosensitivity–ichthyosis–brittle sulfur-deficient hair–impaired intelligence–decreased fertility–short stature syndrome
Pityriasis rotunda (pityriasis circinata, tinea circinata)
Plate-like osteoma cutis
Plaque-type porokeratosis (classic porokeratosis, porokeratosis of Mibelli)
Polyneuropathy–organomegaly–endocrinopathy–monoclonal gammopathy–skin changes syndrome (Crow–Fukase syndrome)
Polyostotic fibrous dysplasia (Albrights disease)
Popliteal pterygium syndrome
Porokeratosis
Porokeratosis palmaris et plantaris disseminata
Prader–Willi syndrome
Progeria (Hutchinson–Gilford progeria syndrome, Hutchinson–Gilford syndrome, progeria syndrome)
Progressive osseous heteroplasia
Progressive symmetric erythrokeratodermia (erythrokeratodermia progressiva symmetrica)
Proteus syndrome
Proteus-like syndrome
Punctate porokeratosis
Rapp–Hodgkin syndrome (Rapp–Hodgkin ectodermal dysplasia syndrome)
Recessive dystrophic epidermolysis bullosa (Hallopeau–Siemens variant of epidermolysis bullosa, Hallopeau–Siemens disease)
Refsums disease (heredopathia atactica polyneuritiformis, phytanic acid storage disease)
Relapsing linear acantholytic dermatosis
Restrictive dermopathy 
Rhizomelic chondrodysplasia punctata (autosomal recessive chondrodysplasia punctata type 1, chondrodystrophia calcificans punctata, peroxisomal biogenesis disorder complementation group 11)
Rombo syndrome
Rothmund–Thomson syndrome (poikiloderma congenitale)
Rud syndrome
Say syndrome
Scalp–ear–nipple syndrome (Finlay–Marks syndrome)
Schindler disease (Kanzaki disease, alpha-N-acetylgalactosaminidase deficiency)
Schinzel–Giedion syndrome
Scleroatrophic syndrome of Huriez (Huriez syndrome, palmoplantar keratoderma with scleroatrophy, palmoplantar keratoderma with sclerodactyly, scleroatrophic and keratotic dermatosis of the limbs, sclerotylosis)
Segmental neurofibromatosis
Senter syndrome (Desmons syndrome)
Shabbir syndrome (laryngo–onycho–cutaneous syndrome)
Silver–Russell syndrome
Sjögren–Larsson syndrome
Skin fragility syndrome (plakophilin 1 deficiency)
Smith–Lemli–Opitz syndrome
Sturge–Weber syndrome
Supernumerary nipples–uropathies–Beckers nevus syndrome
Terminal osseous dysplasia with pigmentary defects
Tooth and nail syndrome (hypodontia with nail dysgenesis, Witkop syndrome)
Townes–Brocks syndrome
Transient bullous dermolysis of the newborn 
Treacher Collins syndrome (Treacher Collins–Franceschetti syndrome)
Tricho–dento–osseous syndrome
Tricho–rhino–phalangeal syndrome
Tuberous sclerosis (Bourneville disease, epiloia)
Turner syndrome
Ulnar–mammary syndrome
Van Der Woude syndrome
Von Hippel–Lindau syndrome
Watson syndrome
Werner syndrome (adult progeria)
Westerhof syndrome
Whistling syndrome (craniocarpotarsal syndrome, distal arthrogryposis type 2, Freeman–Sheldon syndrome, Windmill–Vane–Hand syndrome)
Wilson–Turner syndrome
Wolf–Hirschhorn syndrome (4p- syndrome)
X-linked ichthyosis (steroid sulfatase deficiency, X-linked recessive ichthyosis)
X-linked recessive chondrodysplasia punctata
Xeroderma pigmentosum (Cockayne syndrome complex)
XXYY genotype
Zimmermann–Laband syndrome

Infection-related
Infection-related cutaneous conditions may be caused by bacteria, fungi, yeast, viruses, or parasites.
It is  unknown whether there is a relationship between hypersexuality, pornography addiction, compulsive sexual behavior and POIS. Some evidence indicates that POIS patients have a history of excessive masturbation, suggesting that POIS could be a consequence of sex addiction. There is anecdotal evidence on porn addiction internet forums, that many men experience POIS like symptoms after ejaculation. Other possibilities
POIS could be caused by hyperglycemia or by chemical imbalances in the brain.Sexual activity for the first time may set the stage for an associated asthma attack or may aggravate pre-existing asthma. Intense emotional stimuli during sexual intercourse can lead to autonomic imbalance with parasympathetic over-reactivity, releasing mast cell mediators that can provoke postcoital asthma and / or rhinitis in these patients.It is also possible that the causes of POIS are different in different individuals. POIS could represent "a spectrum of syndromes of differing" causes.None of the proposed causes for POIS fully explain the connection between POIS and lifelong premature ejaculation. Diagnosis
There is no generally agreed upon diagnostic criteria for POIS. One group has developed five preliminary criteria for diagnosing POIS. These are:

POIS is prone to being erroneously ascribed to psychological factors such as hypochondriasis or somatic symptom disorder.An online survey study suggested that only a small number of self-reported POIS fulfill entirely the five criteria. This study proposed to change the Criterion 3 with “In at least one ejaculatory setting (sex, masturbation, or nocturnal emission), symptoms occur after all or almost all ejaculations.”

Management
There is no standard method of treating or managing POIS.