The philosophical premise underlying the importance of rapid stroke intervention was summed up as Time is Brain! in the early 1990s. Years later, that same idea, that rapid cerebral blood flow restoration results in fewer brain cells dying, has been proved and quantified.Tight blood sugar control in the first few hours does not improve outcomes and may cause harm. High blood pressure is also not typically lowered as this has not been found to be helpful. Cerebrolysin, a mixture of pig-derived neurotrophic factors used to treat acute ischemic stroke in many Asian and European countries, does not improve outcomes and may increase the risk of severe adverse events. Thrombolysis
Thrombolysis, such as with recombinant tissue plasminogen activator (rtPA), in acute ischemic stroke, when given within three hours of symptom onset, results in an overall benefit of 10% with respect to living without disability. It does not, however, improve chances of survival. Benefit is greater the earlier it is used. Between three and four and a half hours the effects are less clear. The AHA/ASA recommend it for certain people in this time frame. A 2014 review found a 5% increase in the number of people living without disability at three to six months; however, there was a 2% increased risk of death in the short term. After four and a half hours thrombolysis worsens outcomes. These benefits or lack of benefits occurred regardless of the age of the person treated.
A leg is a weight-bearing and locomotive anatomical structure, usually having a columnar shape. During locomotion, legs function as "extensible struts". The combination of movements at all joints can be modeled as a single, linear element capable of changing length and rotating about an omnidirectional "hip" joint. As an anatomical animal structure it is used for locomotion. The distal end is often modified to distribute force (such as a foot). Most animals have an even number of legs. As a component of furniture, it is used for the economy of materials needed to provide the support for the useful surface such as the table top or chair seat. Terminology
Uniped: 1 leg, such as clams
Biped: 2 legs, such as humans and birds
Triped: 3 legs, which typically does not occur naturally in healthy animals
Quadruped: 4 legs, such as dogs and horsesMany taxa are characterized by the number of legs:

Tetrapods have four legs. Squamates of genus Bipes have only two. Caecilians and many squamate lineages convergently lost their legs. Panarthropoda: no less than 4 legs. Velvet worms and some arthropods have more than a dozen legs; a few species possess over 100. Despite what their names might suggest, centipedes ("hundred feet") may have fewer than 20 or more than 300 legs, and millipedes ("thousand feet") have fewer than 1,000 legs, but up to 750. Components
A leg is a structure of gross anatomy, meaning that it is large enough to be seen unaided. The components depend on the animal.