Risk factors
People who are immunocompromised — such as patients undergoing hematopoietic stem cell transplantation, chemotherapy for leukaemia, or AIDS — are at an increased risk for invasive aspergillosis infections. These people may have neutropenia or corticoid-induced immunosuppression as a result of medical treatments. Neutropenia is often caused by extremely cytotoxic medications such as cyclophosphamide. Cyclophosphamide interferes with cellular replication including that of white blood cells such as neutrophils. A decreased neutrophil count inhibits the ability of the body to mount immune responses against pathogens. Although tumor necrosis factor alpha (TNF-α) — a signaling molecule related to acute inflammation responses — is produced, the abnormally low number of neutrophils present in neutropenic patients leads to a depressed inflammatory response. If the underlying neutropenia is not fixed, rapid and uncontrolled hyphal growth of the invasive fungi will occur and result in negative health outcomes. In addition to decreased neutrophil degranulation, the antiviral response against Flu and SARS-CoV-2 viruses, mediated by type I and type II interferon, is diminished jointly with the local antifungal immune response measured in the lungs of patients with IAPA (Influenza-Associated Pulmonary Aspergillosis) and CAPA (COVID-19-Associated Pulmonary Aspergillosis). Diagnosis
On chest X-ray and CT, pulmonary aspergillosis classically manifests as a halo sign, and later, an air crescent sign. In hematologic patients with invasive aspergillosis, the galactomannan test can make the diagnosis in a noninvasive way.
{\displaystyle \sigma _{\mathrm {fracture} }={\sqrt {\frac {E\gamma \rho }{4ar_{o}}}}.} Sharp cracks (small 
  
    
      
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  ) both lower the fracture strength of the material. Recently, scientists have discovered supersonic fracture, the phenomenon of crack propagation faster than the speed of sound in a material. This phenomenon was recently also verified by experiment of fracture in rubber-like materials. The basic sequence in a typical brittle fracture is: introduction of a flaw either before or after the material is put in service, slow and stable crack propagation under recurring loading, and sudden rapid failure when the crack reaches critical crack length based on the conditions defined by fracture mechanics. Brittle fracture may be avoided by controlling three primary factors: material fracture toughness (Kc), nominal stress level (σ), and introduced flaw size (a). Residual stresses, temperature, loading rate, and stress concentrations also contribute to brittle fracture by influencing the three primary factors.Under certain conditions, ductile materials can exhibit brittle behavior. Rapid loading, low temperature, and triaxial stress constraint conditions may cause ductile materials to fail without prior deformation.