Crotalidae polyvalent immune fab, sold under the brandname CroFab, is a snake antivenin, indicated for minimal or moderate North American Crotalid (Rattlesnake, Copperhead and Cottonmouth/Water moccasin) snake envenomation. CroFab is composed of several monovalent Fragment antigen-binding proteins (Fab) derived from the blood of sheep immunized with one of four snake venom: Crotalus atrox (western diamondback rattlesnake), Crotalus adamanteus (Eastern diamondback rattlesnake), Crotalus scutulatus (Mojave rattlesnake), or Agkistrodon piscivorus (Cottonmouth or Water Moccasin). Each monospecific antivenin is purified from sheep serum, digested with the enzyme papain, and purified further resulting in specific Fab fragments. The resulting four different Fab preparations are mixed to formulate the final product. Background
It was developed by the Venom Immunochemistry, Pharmacology and Emergency Response (VIPER) Institute, University of Arizona, and commercialized by BTG plc (formerly Protherics PLC). As reported in the Washington Post in July 2015, this was the only commercially available antivenin in the United States for the treatment of venomous snakebites until the release of a competing product, ANAVIP. Treatment
Crotalid snakebites can range from mild to life-threatening, depending on the size and type of snake, the amount of venom injected and the location of the bite. This in turn determines the number of vials of CroFab that are required by the patient. Untreated, the snake venom can cause severe pain and tissue damage that can result in the loss of a limb or even death. Prompt (within six hours of snake bite) treatment with CroFab is recommended. Fab refers to Fragment Antigen-Binding, the active mechanism for this antivenom.
For example, Albert Dubout depicted the Great Goddess as eliciting fear from a short man simply by displaying her large breasts and noting that her breasts survived World War II.In India, the goddess "Kali the Terrible" is the mother of the world and a fearsome, gruesome, and bloodthirsty destroyer of human life. She partially expresses her destruction through a wide array of female avatars (or "agents"). Kalis avatars and agents are regarded by believers as responsible for serious maladies such as typhoid fever, whooping cough, epilepsy, delirium, and convulsions. For example, Kalis agent goddess Vasurimala is mythologized as responsible for smallpox and cholera. Believers in the rural Indian town of Cranganore, make symbolic monetary offerings to Kali, to fulfill promises made in fear of being stricken with smallpox or cholera.Woman as "Great Goddess" was often depicted as a goddess of death in ancient Greek mythology as well. For example, in ancient Greek mythology, at least 7 female goddesses are depicted as both nursing mothers and as queens of the dead. Case studies
In his book Sadism and Masochism: The Psychology of Hatred and Cruelty, Wilhelm Stekel  discusses horror feminae of a male masochist. Proposed possible causes
Envy of mothers genitals
In The Dread of Woman (1932), Karen Horney proposed that gynophobia may be partially due to a boys fear that his genital is inadequate in relation to the mother. She also remarked that she was surprised at the lack of explicit recognition of gynophobia, after she allegedly found ample historical, clinical, mythological, and anthropological evidence of gynophobia.