In sports
In many professional sports, the number 1 is assigned to the player who is first or leading in some respect, or otherwise important; the number is printed on his sports uniform or equipment. This is the pitcher in baseball, the goalkeeper in association football (soccer), the starting fullback in most of rugby league, the starting loosehead prop in rugby union and the previous years world champion in Formula One. 1 may be the lowest possible player number, like in the American–Canadian National Hockey League (NHL) since the 1990s or in American football. In other fields
Number One is Royal Navy informal usage for the chief executive officer of a ship, the captains deputy responsible for discipline and all normal operation of a ship and its crew. 1 is the value of an ace in many playing card games, such as cribbage. List of highways numbered 1
List of public transport routes numbered 1
1 is often used to denote the Gregorian calendar month of January. 1 CE, the first year of the Common Era
01, the former dialling code for Greater London (now 020)
For Pythagorean numerology (a pseudoscience), the number 1 is the number that means beginning, new beginnings, new cycles, it is a unique and absolute number. PRS One, a German paraglider design
+1 is the code for international telephone calls to countries in the North American Numbering Plan.
Neuroferritinopathy  is a genetic neurodegenerative disorder characterized by the accumulation of iron in the basal ganglia, cerebellum, and motor cortex of the human brain. Symptoms, which are extrapyramidal in nature, progress slowly and generally do not become apparent until adulthood. These symptoms include chorea, dystonia, and cognitive deficits which worsen with age.This disorder is autosomal dominant and is caused by mutations in the gene encoding the light chain subunit of the ferritin protein. Wild type ferritin functions as a buffer for iron, sequestering it and controlling its release. Thus, mutations in the light chain of ferritin result in the accumulation of iron in the brain which can be imaged using MRI. Currently, neuroferritinopathy is the only neurodegenerative disease with an iron accumulation in the brain classified as an autosomal dominant syndrome.Treatment of neuroferritinopathy is focused on managing symptoms associated with chorea and dystonia using standard medications for each. The disorder is progressive and symptoms become worse with age. Fewer than 100 cases of neuroferritinopathy have been reported since its identification in 2001. Its incidence has been largely localized to Northeast England suggesting a founder effect. Due to its genetic nature, current research is focused on therapeutic management of the symptoms caused by the disorder. Signs and symptoms
Neuroferritinopathy has several distinguishing signs and symptoms. These fall into two categories: diagnostic findings and physically visible symptoms. Diagnostic findings
Symptoms categorized as medically tested and diagnosed include iron accumulation in the brain, basal ganglia cavitation, and neurodegeneration.