Adverse effects
Adverse effect incidence:Uncommon (0.1–1% incidence) adverse effects include:

Dry mouth
Anhidrosis (reduced ability to sweat to cool off)
Tachycardia (usually occurs at higher doses and is succeeded by bradycardia)
Bradycardia
Urticaria (hives)
Pruritus (itching)Rare (<0.1% incidence) adverse effects include:

Constipation
Urinary retention
Hallucinations
Agitation
Confusion
Restlessness
SeizuresUnknown frequency adverse effects include:

Anaphylactic shock or reactions
Dyspnea (shortness of breath)
Rash
Erythema
Other hypersensitivity reactions
Blurred vision
Mydriasis (dilated pupils)
Drowsiness
Dizziness
Somnolence

Overdose
Physostigmine, a cholinergic drug that readily crosses the blood-brain barrier, has been used as an antidote to treat the central nervous system depression symptoms of a scopolamine overdose. Other than this supportive treatment, gastric lavage and induced emesis (vomiting) are usually recommended as treatments for oral overdoses. The symptoms of overdose include:
Tachycardia
Arrhythmia
Blurred vision
Photophobia
Urinary retention
Drowsiness or paradoxical reaction, which can present with hallucinations
Cheyne-Stokes respiration
Dry mouth
Skin reddening
Inhibition of gastrointestinal motility

Interactions
Due to interactions with metabolism of other drugs, scopolamine can cause significant unwanted side effects or unpredictable synergies when taken with other medications or compounds. Specific attention should be paid to other medications in the same pharmacologic class as scopolamine, also known as anticholinergics. These additional compounds could also potentially interact with the metabolism of scopolamine: receptor-binding analgesic/pain medication such as gabapentinoids or opioids, ethanol, cannabinoids, zolpidem, thiazide diuretics, nicotine, benzodiazepines, buprenorphine, and especially anticholinergic drugs such as tiotropium, diphenhydramine, dimenhydrinate, etc. Route of administration
Scopolamine can be taken by mouth, subcutaneously, in the eye, and intravenously, as well as via a transdermal patch. Pharmacokinetic
Scopolamine undergoes first-pass metabolism and about 2.6% is excreted unchanged in urine. Grapefruit juice decreases metabolism of scopolamine consequently increasing plasma concentration.
A milium (plural milia), also called a milk spot or an oil seed, is a clog of the eccrine sweat gland. It is a keratin-filled cyst that can appear just under the epidermis or on the roof of the mouth. : 780  Milia are commonly associated with newborn babies, but can appear on people of all ages. : 680  They are usually found around the nose and eyes, and sometimes on the genitalia, often mistaken by those affected as warts or other sexually transmitted diseases. Milia can also be confused with stubborn whiteheads. In children, milia often disappear within two to four weeks. For adults, they can be removed by a physician (a dermatologist has specialist knowledge in this area). A common method that a dermatologist uses to remove a milium is to nick the skin with a #11 surgical blade and then use a comedone extractor to press the cyst out. See also
Eruptive vellus hair cyst
Sebaceous hyperplasia
Seborrheic keratosis


== References ==