The Midwest and Northeast likely had a higher prevalence of ALS because they have a higher proportion of whites than the South and West. Ethnically mixed populations may be at a lower risk of developing ALS; a study in Cuba found that people of mixed ancestry were less likely to die from ALS than whites or blacks. There are also differences in the genetics of ALS between different ethnic groups; the most common ALS gene in Europe is C9orf72, followed by SOD1, TARDBP, and FUS, while the most common ALS gene in Asia is SOD1, followed by FUS, C9orf72, and TARDBP. ALS can affect people at any age, but the peak incidence is between 50 and 75 years and decreases dramatically after 80 years. The reason for the decreased incidence in the elderly is unclear. One thought is that people who survive into their 80s may not be genetically susceptible to developing ALS; alternatively, ALS in the elderly might go undiagnosed because of comorbidities (other diseases they have), difficulty seeing a neurologist, or dying quickly from an aggressive form of ALS. In the United States in 2015, the lowest prevalence was in the 18–39 age group, while the highest prevalence was in the 70–79 age group. Sporadic ALS usually starts around the ages of 58 to 63 years, while familial ALS starts earlier, usually around 47 to 52 years. The number of ALS cases worldwide is projected to increase from 222,801 in 2015 to 376,674 in 2040, an increase of 69%.
Intraocular hemorrhage is bleeding (hemorrhage) inside the eye (oculus in Latin) . It may be the result of physical trauma (direct injury to the eye) or other diseases, injuries or disorders (such as diabetes, hypertension, or shaken baby syndrome). Severe bleeding may cause high pressures inside the eye, leading to blindness. Types
The types of ocular hemorrhages are classified based on where the bleeding is occurring:

Subconjunctival hemorrhage (bleeding just underneath the conjunctiva)
Intraocular hemorrhages:
Hyphema (in the anterior chamber)
In the posterior segment of eyeball:
Vitreous hemorrhage (into the vitreous)
Subretinal hemorrhage (under the retina)
Submacular hemorrhage (under the macula)

Causes
Different causes may cause bleeding in different locations. Tersons syndrome (as a result of subarachnoid hemorrhage)
Hemophilia (a severe bleeding disorder, usually hereditary)
Anticoagulants and thrombolysis (medication to reduce blood clotting tendency or to disperse blood clots, respectively)The major causes of bleeding are injury diabetes mellitus hypertension. Diagnosis
Intraocular hemorrhage is typically diagnosed with slit lamp examination. Treatment
References


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