Amifostine is believed to radioprotect normal tissue via Warburg-type effects. Adverse effects
Common side effects of amifostine include hypocalcemia, diarrhea, nausea, vomiting, sneezing, somnolence, and hiccups. Serious side effects include: hypotension (found in 62% of patients), erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis, immune hypersensitivity syndrome, erythroderma, anaphylaxis, and loss of consciousness (rare). Contraindications
Contraindications to receiving amifostine include hypersensitivity to amifostine and aminothiol compounds like WR-1065. Ethyol contains mannitol. == References ==
Terminology
Because prothrombin is also known as factor II, the mutation is also sometimes referred to as the factor II mutation or simply the prothrombin mutation; in either case, the names may appear with or without the accompanying G20210A location specifier (unhelpfully, since prothrombin mutations other than G20210A are known). Notes
References
External links

Mannucci, P. M. & Franchini, M. (2015). "Classic thrombophilic gene variants". Thrombosis and Haemostasis. 114 (5): 885–889. doi:10.1160/th15-02-0141. PMID 26018405. Archived from the original (review) on 10 June 2016. Retrieved 21 May 2016.