In particular, individuals who are homozygous for the G allele at the single nucleotide polymorphism (SNP) rs776746 (also known as CYP3A5 *3/*3) have a non-functional CYP3A5 protein. The frequency of the G allele varies worldwide, from 4% in some African populations to 80–90% in Caucasian populations. Across a large number of studies, individuals homozygous for the G allele have been shown to have higher concentrations of tacrolimus and require lower doses of the drug, as compared to individuals who are not homozygous for the G allele. Achieving target concentrations of tacrolimus is important – if levels are too low, then there is a risk of transplant rejection, if levels are too high, there is a risk of drug toxicities. There is evidence to suggest that dosing patients based on rs776746 genotype can result in faster and more frequent achievement of target tacrolimus levels. However, there is a lack of consistent evidence as to whether dosing based on rs776746 genotype results in improved clinical outcomes (such as a decreased risk for transplant rejection or drug toxicities), likely because patients taking tacrolimus are subject to therapeutic drug monitoring.Studies have shown that genetic polymorphisms of genes other than CYP3A5, such as NR1I2 (encoding PXR), also significantly influence the pharmacokinetics of tacrolimus. History
Tacrolimus was discovered in 1987; it was among the first macrolide immunosuppressants discovered, preceded by the discovery of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975. It is produced by a soil bacterium, Streptomyces tsukubensis.
Camila is the Portuguese and Spanish form of the given name Camilla and may refer to:

Film and television
Camila (TV series), a Mexican telenovela from 1998
Camila (film), a 1984 Argentine film by María Luisa Bemberg

Music
Camila (band), Mexican band
Camila (album), Camila Cabellos debut studio album released 2018
"Camila, Camila", a song by Brazilian rock band Nenhum de Nós

Other uses
Camila (Pontus), a town of ancient Pontus, in Anatolia
Camila Martins Pereira (born 1994), Brazilian footballer known by the mononym Camila
Camila, brand name of a progestogen-only pill containing norethisterone (norethindrone)

See also
Camilla (disambiguation)
Camilla (born 1947), Queen consort of Charles III of the United Kingdom