Nadolol, a powerful non-selective beta blocker, has been shown to reduce the arrhythmic risk in all three main genotypes (LQT1, LQT2, and LQT3).Genotype and QT interval duration are independent predictors of recurrence of life-threatening events during beta-blocker therapy. To be specific, the presence of QTc >500 ms and LQT2 and LQT3 genotype are associated with the highest incidence of recurrence. In these patients, primary prevention with use of implantable cardioverter-defibrillators can be considered. Potassium supplementation: If the potassium content in the blood rises, the action potential shortens, so increasing potassium concentration could minimize the occurrence of arrhythmias. It should work best in LQT2, since the hERG channel is especially sensitive to potassium concentration, but the use is experimental and not evidence-based. Sodium channel blocking drugs such as mexiletine have been used to prevent arrhythmias in long QT syndrome. While the most compelling indication is for those whose long QT syndrome is caused by defective sodium channels producing a sustained late current (LQT3), mexiletine also shortens the QT interval in other forms of long QT syndrome including LQT1, LQT2 and LQT8. As the predominant action of mexiletine is on the early peak sodium current, there are theoretical reasons why drugs which preferentially suppress the late sodium current such as ranolazine may be more effective, although evidence that this is the case in practice is limited. Amputation of the cervical sympathetic chain (left stellectomy). This therapy is typically reserved for LQTS caused by JLNS, but may be used as an add-on therapy to beta blockers in certain cases.
Symphysiotomy is suggested for woman in isolated areas experiencing obstructed labor where other medical intervention is unavailable.This practice was carried out in Europe before the introduction of the Caesarean section. Historically, during obstructed labor, the skull of the fetus was also, at least occasionally, crushed in order to further facilitate the delivery. Society and culture
Use in forensic anthropology
Pubic symphyses have importance in the field of forensic anthropology, as they can be used to estimate the age of adult skeletons. Throughout life, the surfaces are worn at a fairly predictable rate. By examining the wear of the pubic symphysis, it is possible to estimate the age of the person at death. Additional images
See also
References
External links
Pelvic Instability Network Support (PINS)
Anatomy photo:17:st-0206 at the SUNY Downstate Medical Center – "Major Joints of the Lower Extremity – hip and sacrum (anterior view)"
Anatomy photo:44:03-0104 at the SUNY Downstate Medical Center – "The Male Pelvis: Hemisection of the Male Pelvis"
Cross section image: pelvis/pelvis-e12-15—Plastination Laboratory at the Medical University of Vienna