These warning centres issue advisories which provide basic information and cover a systems present, forecast position, movement and intensity, in their designated areas of responsibility. Meteorological services around the world are generally responsible for issuing warnings for their own country, however, there are exceptions, as the United States National Hurricane Center and Fiji Meteorological Service issue alerts, watches and warnings for various island nations in their areas of responsibility. The United States Joint Typhoon Warning Center and Fleet Weather Center also publicly issue warnings, about tropical cyclones on behalf of the United States Government. The Brazilian Navy Hydrographic Center names South Atlantic tropical cyclones, however the South Atlantic is not a major basin, and not an official basin according to the WMO. Preparations
Ahead of the formal season starting, people are urged to prepare for the effects of a tropical cyclone by politicians and weather forecasters, amongst others. They prepare by determining their risk to the different types of weather, tropical cyclones cause, checking their insurance coverage and emergency supplies, as well as determining where to evacuate to if needed. When a tropical cyclone develops and is forecast to impact land, each member nation of the World Meteorological Organization issues various watches and warnings to cover the expected impacts. However, there are some exceptions with the United States National Hurricane Center and Fiji Meteorological Service responsible for issuing or recommending warnings for other nations in their area of responsibility.
It is thought that bimatoprost mimics the human bodys own prostamides (which are chemically similar), a class of substances related to prostaglandins, but with an unknown mechanism of action. No prostamide receptor has been identified as of 2015; the search is ongoing. As of 2019 it was thought that bimatoprost worked via the trabecular meshwork and uveoscleral pathways. Pharmacokinetics
Bimatoprost is well absorbed through the cornea. It starts lowering intraocular pressure after four hours, lasting for at least 24 hours. A low percentage enters the bloodstream. In the blood plasma, peak concentrations are reached after 10 minutes, then drop below the detection limit of 25 pg/ml after 1.5 hours. The substance does not accumulate in the body.Plasma protein binding is 88%. Bimatoprost is metabolized by oxidation, N-deethylation and glucuronidation, forming a variety of metabolites. Biological half-life was measured to be 45 minutes after intravenous infusion. 67% are eliminated via the kidney, and 25% via the feces. References
Further reading
"Prostaglandin Analogues for Ophthalmic Use: A Review of the Comparative Clinical Effectiveness and Cost-Effectiveness". CADTH Rapid Response Reports. July 2015. PMID 26985536. External links
"Bimatoprost". Drug Information Portal. U.S. National Library of Medicine.