These individuals are also at far greater risk of severe hypoglycemia.While the exact cause of hypoglycemic unawarenss is still under research, it is thought that these individuals progressively begin to develop fewer adrenergic-type symptoms, resulting in the loss of  neuroglycopenic-type symptoms. Neuroglycopenic symptoms are caused by low glucose in the brain, and can result in tiredness, confusion, difficulty with speech, seizures, and loss of consciousness. Adrenergic symptoms are caused by the bodys reaction to low glucose in the brain, and can result in fast heart rate, sweating, nervousness, and hunger. See section above on Signs and Symptoms for further explanation of neuroglycopenic symptoms and adrenergic symptoms. In terms of epidemiology, hypoglycemic unawarenss occurs in 20-40% of type 1 diabetics. Other causes
Other causes of hypoglycemia in diabetics include the following:

Fasting, whether it be a planned fast or overnight fast, as there is a long period of time without glucose intake
Exercising more than usual as it leads to more use of glucose, especially by the muscles
Drinking alcohol, especially when combined with diabetic medications, as alcohol inhibits glucose production
Kidney disease, as insulin cannot be cleared out of circulation well

Non-diabetics
Serious illness
Serious illness may result in low blood sugar. Severe disease of many organ systems can cause hypoglycemia as a secondary problem. Hypoglycemia is especially common in those in the intensive care unit or those in whom food and drink is withheld as a part of their treatment plan.Sepsis, a common cause of hypoglycemia in serious illness, can lead to hypoglycemia through many ways.
Treatment in humans consists of anti-inflammatory medication, cortisone injections, strapping to immobilize the big toe, and orthotics with special accommodations to keep pressure off the affected bone. In horses, sesamoiditis is generally caused by excess stress on the fetlock joint. Conformation that promotes sesamoiditis include long pasterns, or horses with long toes and low heels. Notable cases
Josh Zeid, major league baseball pitcher
Melvin Upton, major league baseball player 
JJ ODonnell, football player for Gateshead FC

References


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