Prevention
After reporting a null finding from their randomized controlled trial of aspirin (acetylsalicylic acid – ASA) to prevent the colorectal neoplasia of Lynch syndrome, Burn and colleagues have reported new data, representing a longer follow-up period than reported in the initial NEJM paper. These new data demonstrate a reduced incidence in people with Lynch syndrome who were exposed to at least four years of high-dose aspirin, with a satisfactory risk profile. These results have been widely covered in the media; future studies will look at modifying (lowering) the dose (to reduce risk associated with the high dosage of ASA). Screening
Genetic counseling and genetic testing are recommended for families that meet the Amsterdam criteria, preferably before the onset of colon cancer. Colon cancer
Colonoscopies are recommended as a preventative method of surveillance for individuals who have Lynch syndrome, or LS-associated genes. Specifically, it is recommended that colonoscopies begin at ages 20–25 for MLH1 and MSH2 mutation carriers and 35 years for MSH6 and PMS2 mutation carriers. Colonoscopic surveillance should then be performed at a 1-2 year interval for Lynch Syndrome patients.Endometrial/Ovarian cancer
A transvaginal ultrasound with or without endometrial biopsy is recommended annually for ovarian and endometrial cancer screening.
Zarah may refer to:

Zarah (television personality), a Filipino-American, also a singer
Zarah Garde-Wilson (born 1978), Australian solicitor
Zarah Ghahramani (born 1981), Iranian-born author living in Australia
Zarah Leander (1907 – 1981), Swedish actress and singer
Zarah, or Ich weiss, es wird einmal ein Wunder geschehen, a song by Nina Hagen
Fort Zarah

See also
Zahra (name)
Zara (disambiguation)
Zaraah Abrahams, English actress