Demand became so great that within three years, Dr. Sappington founded a company known as Sappington and Sons to sell his pills nationwide. Society and culture
Natural occurrence
The bark of Remijia contains 0.5–2% of quinine. The bark is cheaper than bark of Cinchona. As it has an intense taste, it is used for making tonic water. Regulation in the US
From 1969, to 1992, the US Food and Drug Administration (FDA) received 157 reports of health problems related to quinine use, including 23 which had resulted in death. In 1994, the FDA banned the marketing of over-the-counter quinine as a treatment for nocturnal leg cramps. Pfizer Pharmaceuticals had been selling the brand name Legatrin for this purpose. Also sold as a Softgel (by SmithKlineBeecham) as Q-vel. Doctors may still prescribe quinine, but the FDA has ordered firms to stop marketing unapproved drug products containing quinine. The FDA is also cautioning consumers about off-label use of quinine to treat leg cramps. Quinine is approved for treatment of malaria, but was also commonly prescribed to treat leg cramps and similar conditions. Because malaria is life-threatening, the risks associated with quinine use are considered acceptable when used to treat that condition.Though Legatrin was banned by the FDA for the treatment of leg cramps, the drug manufacturer URL Mutual has branded a quinine-containing drug named Qualaquin. It is marketed as a treatment for malaria and is sold in the United States only by prescription. In 2004, the CDC reported only 1,347 confirmed cases of malaria in the United States.
In phonetics, denasalization is the loss of nasal airflow in a nasal sound, such as a nasal consonant or a nasal vowel. That may be due to speech pathology but also occurs when the sinuses are blocked from a common cold, when it is called a nasal voice, which is not a linguistic term. Acoustically, it is the "absence of the expected nasal resonance." The symbol in the Extended IPA is ⟨◌͊⟩. When one speaks with a cold, the nasal passages still function as a resonant cavity so a denasalized nasal [m͊] does not sound like a voiced oral stop [b], and a denasalized vowel [a͊] does not sound like an oral vowel [a]. However, there are cases of historical or allophonic denasalization that have produced oral stops. In some languages with nasal vowels, such as Paicĩ, nasal consonants may occur only before nasal vowels; before oral vowels, prenasalized stops are found. That allophonic variation is likely to be from a historical process of partial denasalization. Similarly, several languages around Puget Sound underwent a process of denasalization about 100 years ago. Except in special speech registers, such as baby talk, the nasals [m, n] became the voiced stops [b, d]. It appears from historical records that there was an intermediate stage in which the stops were prenasalized stops [ᵐb, ⁿd] or poststopped nasals [mᵇ, nᵈ]. Something similar has occurred with word-initial nasals in Korean; in some contexts, /m/, /n/ are denasalized to [b, d].