Likewise, analogues of three-dimensional icosahedral symmetry 
  
    
      
        
          
            I
          
          
            h
          
        
      
    
    {\displaystyle \mathrm {I} _{h}}
   or  four-dimensional 
  
    
      
        
          
            H
          
          
            4
          
        
      
    
    {\displaystyle \mathrm {H} _{4}}
   symmetry do not exist in dimensions n ⩾ 5; however, there is the uniform prismatic group 
  
    
      
        
          
            H
          
          
            4
          
        
      
    
    {\displaystyle \mathrm {H} _{4}}
   × 
  
    
      
        
          
            A
          
          
            1
          
        
      
    
    {\displaystyle \mathrm {A} _{1}}
   in the fifth dimension which contains prisms of regular and uniform 4-polytopes that have 
  
    
      
        
          
            H
          
          
            4
          
        
      
    
    {\displaystyle \mathrm {H} _{4}}
   symmetry.
Therefore, multi-disciplinary approach is required including physical therapies, psychiatric and ophthalmologic consultations, nutrition and well-balanced diet. Physical therapy aims at improving the strength and ability using assisting tools such as ankle-foot orthitic braces, weight-bearing walkers and regular exercise. Eponym and nomenclature
It is named after the physicians John Zachariah Laurence and Robert Charles Moon who provided the first formal description of the condition in a paper published in 1866. In the past, LMS has also been referred to as Laurence–Moon–Bardet–Biedl or Laurence–Moon–Biedl–Bardet syndrome, but Bardet–Biedl syndrome (BBS) is now usually recognized as a separate entity.Recent advances in genetic typing of the phenotypically-wide variation in patients clinically diagnosed with either Bardet-Biedl Syndrome (BBS) or Laurence-Moon Syndrome (LMS) have questioned whether LMS and BBS are genetically distinct. For example, a 1999 epidemiological study of BBS and LMS reported that "BBS proteins interact and are necessary for the development of many organs." "Two patients [in the study] were diagnosed clinically as LMS but both had mutations in a BBS gene. The features in this population do not support the notion that BBS and LMS are distinct." A more recent 2005 paper also suggests that the two conditions are not distinct. References


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