The drug is a member of the diphenylmethylpiperazine group of antihistamines. Analogues include cyclizine and hydroxyzine. Synthesis
The 1-(4-chlorophenylmethyl)-piperazine is alkylated with methyl (2-chloroethoxy)-acetate in the presence of sodium carbonate and xylene solvent to produce the Sn2 substitution product in 28% yield. Saponification of the acetate ester is done by refluxing with potassium hydroxide in absolute ethanol to afford a 56% yield of the potassium salt intermediate. This is then hydrolyzed with aqueous HCl and extracted to give an 81% yield of the carboxylic acid product. Availability
Formerly prescription-only in many countries, cetirizine is now available without prescription in most countries. In some countries it is available over-the-counter only in packages containing seven or ten 10 mg doses.Like many other antihistamine medications, cetirizine is commonly prescribed in combination with pseudoephedrine, a decongestant. These combinations are often marketed using the same brand name as the cetirizine with a "-D" suffix (Zyrtec-D, Virlix-D, etc. )Cetirizine is marketed under the brand names Alatrol, Alerid, Alzene, Cerchio, Cetirin, Cetriz, Cetzine, Cezin, Cetgel, Cirrus, Histec, Histazine, Humex, Letizen, Okacet (Cipla), Piriteze, Reactine, Razene, Rigix, Sensahist (Oethmann, South Africa), Triz, Zetop, Zirtec, Zirtek, Zodac, Zyllergy, Zynor, Zyrlek, and Zyrtec (Johnson & Johnson), among others. References
External links
"Cetirizine". Drug Information Portal. U.S. National Library of Medicine. Cetirizine Tablet Uses In Hindi
A nuchal cord is when the umbilical cord becomes wrapped around the fetuss neck. Symptoms present in the baby shortly after birth from a prior nuchal cord may include duskiness of face, facial petechia, and bleeding in the whites of the eye. Complications can include meconium, respiratory distress, anemia, and stillbirth. Multiple wraps are associated with greater risk.The diagnosis may be suspected if there is a decrease in the babys heart rate during delivery. Nuchal cords are typically checked for by running the finger over the babys neck once the head has delivered. Ultrasound may pick up the condition before labor.If detected during delivery, management includes trying to unwrap the cord or if this is not possible clamping and cutting the cord. Delivery can typically take place as normal and outcomes are generally good. Rarely long term brain damage or cerebral palsy may occur. Nuchal cords occur in about a quarter of deliveries. The condition has been described at least as early as 300 BC by Hippocrates. Signs and symptoms
Symptoms of a prior nuchal cord shortly after birth in the baby may include duskiness of face, facial petechia, and bleeding in the whites of the eye. Complications can include meconium, respiratory disease, anemia, and still birth. Diagnosis
In 1962, J. Selwyn Crawford MD from the British Research Council defined a nuchal cord as one that is wrapped 360 degrees around the fetal neck. Crawford commented "It is all the more remarkable, therefore, that little work has been done. to analyze its effects during labor and delivery".