Frequently, a differential diagnosis for CBD is performed, in which other diseases are eliminated based on specific symptoms that do not overlap. However, some of the symptoms of CBD used in this process are rare to the disease, and thus the differential diagnosis cannot always be used.Postmortem diagnosis provides the only true indication of the presence of CBD. Most of these diagnoses utilize the Gallyas-Braak staining method, which is effective in identifying the presence of astroglial inclusions and coincidental tauopathy. Overlap with other diseases
Progressive supranuclear palsy (PSP) is frequently the disease most often confused with CBD. Both PSP and CBD result in similar symptoms, and both display tauopathies upon histological inspection. However, it has been noted that tauopathy in PSP results in tuft-shaped astrocytes in contrast with the ring-shaped astrocytic plaques found as a result of CBD.Individuals diagnosed with PD often exhibit similar movement dysfunction as those diagnosed with CBD, which adds complexity to its diagnosis. Some other neurodegenerative diseases including Alzheimers disease (AD), dementia with Lewy bodies (DLB), chronic traumatic encephalopathy (CTE) and frontotemporal dementia (FTD) also show commonalities with CBD. Neuroimaging
The types of imaging techniques that are most prominently utilized when studying and/or diagnosing CBD are:
magnetic resonance imaging (MRI)
single-photon emission computed tomography (SPECT)
fluorodopa positron emission tomography (FDOPA PET)Developments or improvements in imaging techniques provide the future possibility for definitive clinical diagnosis prior to death.
Society and culture
The Salt Path by Raynor Winn is an inspiring account of walking Englands 630 mile South West Coast Path with her husband who had corticobasal degeneration. See also
Frontotemporal lobar degeneration

References

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