Revlimid is available only in a restricted distribution setting to avoid its use during pregnancy. Further studies are being conducted to find safer compounds with useful qualities. Another more potent analog, pomalidomide, is now FDA approved. Additionally, apremilast was approved by the FDA in March 2014. These thalidomide analogs can be used to treat different diseases, or used in a regimen to fight two conditions.Interest turned to pomalidomide, a derivative of thalidomide marketed by Celgene. It is a very active anti-angiogenic agent   and also acts as an immunomodulator. Pomalidomide was approved in February 2013 by the U.S. Food and Drug Administration (FDA) as a treatment for relapsed and refractory multiple myeloma. It received a similar approval from the European Commission in August 2013, and is expected to be marketed in Europe under the brand name Imnovid. Clinical research
There is no conclusive evidence that thalidomide or lenalidomide is useful to bring about or maintain remission in Crohns disease.Thalidomide was studied in a Phase II trial for Kaposis sarcoma, a rare soft-tissue cancer most commonly seen in the immunocompromised, that is caused by the Kaposis sarcoma-associated herpesvirus (KSHV). References
Further reading
External links
"Thalidomide". Drug Information Portal. U.S. National Library of Medicine. Daemmrich A (7 December 2015). "Remind me again, what is thalidomide and how did it cause so much harm". The Conversation.
5 (5): CD006685. doi:10.1002/14651858.CD006685.pub4. PMC 7386458. PMID 27153153. Pearce, J. M. (2008). "Kleine–Levin Syndrome: History and Brief Review". European Neurology. 60 (4): 212–4. doi:10.1159/000148694. PMID 18667831. Ramdurg, Santosh (2010). "Kleine–Levin Syndrome: Etiology, Diagnosis, and Treatment". Annals of Indian Academy of Neurology. 13 (4): 241–6. doi:10.4103/0972-2327.74185. PMC 3021925. PMID 21264130. External links

kleine_levin at NINDS
Story of young man with Kleine–Levin syndrome at The New York Times