Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. For heart failure, it is generally used with a diuretic, such as furosemide. It is given by mouth or by injection into a vein. Onset of effects are typically within an hour when taken by mouth and last for up to a day.Common side effects include headache, tiredness, feeling lightheaded with standing, and cough. Serious side effects include angioedema and low blood pressure. Use during pregnancy is believed to result in harm to the baby. It is in the angiotensin-converting-enzyme (ACE) inhibitor family of medications.Enalapril was patented in 1978, and came into medical use in 1984. It is on the World Health Organizations List of Essential Medicines. In 2019, it was the 137th most commonly prescribed medication in the United States, with more than 4 million prescriptions. As of August 2021, enalapril is available as a generic medicine in the US. Structure Activity Relationship
Enalapril has an L-proline moiety as a part of the molecule which is responsible for the oral bioavailability of the drug. It is a pro-drug, which means that it exerts its function after being metabolized. The "-OCH2CH3" part of the molecule will split during the metabolism and at the carbon will be a carboxylate, which then interacts with the Zn+2 site of the ACE Enzyme.
Elephantiasis is the enlargement and hardening of limbs or body parts due to tissue swelling. It is characterised by edema, hypertrophy, and fibrosis of skin and subcutaneous tissues, due to obstruction of lymphatic vessels. It may affect the genitalia. The term elephantiasis is often used in reference to (symptoms caused by) parasitic worm infections, but may refer to a variety of diseases where parts of a persons body swell to massive proportions. Cause
Some conditions that present with elephantiasis include:

Elephantiasis nostras, due to longstanding chronic lymphangitis
Elephantiasis tropica (known as lymphatic filariasis), caused by a number of parasitic worms, particularly Wuchereria bancrofti. More than 120 million people, mostly in Africa and Southeast Asia, are affected. Nonfilarial elephantiasis (or podoconiosis), an immune disease affecting the lymph vessels
Leishmaniasis
Elephantiasis, Grade 3 lymphedema which may occur in people with breast cancer
Genital elephantiasis, result of lymphogranuloma venereum
Proteus syndrome, a genetic disorder best known as the condition possibly experienced by Joseph Merrick, the so-called "Elephant Man. "Other causes may include:

Repeated streptococcal infection
Lymphadenectomy
Hereditary birth defects
Pretibial myxedema

References
External links

"Lymphatic filariasis". World Health Organization. Retrieved 1 June 2018.