Where dietary allergens are responsible, mouth ulcers usually develop within about 12–24 hours of exposure.Sodium lauryl sulphate (SLS), a detergent present in some brands of toothpaste and other oral healthcare products, may produce oral ulceration in some individuals. It has been shown that aphthous stomatitis is more common in people using toothpastes containing SLS, and that some reduction in ulceration occurs when a SLS-free toothpaste is used. Some have argued that since SLS is almost ubiquitously used in oral hygiene products, there is unlikely to be a true predisposition for aphthous stomatitis caused by SLS. Systemic disease
Aphthous-like ulceration may occur in association with several systemic disorders (see table). These ulcers are clinically and histopathologically identical to the lesions of aphthous stomatitis, but this type of oral ulceration is not considered to be true aphthous stomatitis by some sources. Some of these conditions may cause ulceration on other mucosal surfaces in addition to the mouth such as the conjunctiva or the genital mucous membranes. Resolution of the systemic condition often leads to decreased frequency and severity of the oral ulceration.Behçets disease is a triad of mouth ulcers, genital ulcers and anterior uveitis. The main feature of Behçets disease is aphthous-like ulceration, but this is usually more severe than seen in aphthous stomatitis without a systemic cause, and typically resembles major or herpetiforme ulceration or both. Aphthous-like ulceration is the first sign of the disease in 25–75% of cases.
Colic or cholic () is a form of pain that starts and stops abruptly. It occurs due to muscular contractions of a hollow tube (small and large intestine, gall bladder, ureter, etc.) in an attempt to relieve an obstruction by forcing content out. It may be accompanied by sweating and vomiting. Types include:

Baby colic, a condition, usually in infants, characterized by incessant crying
Biliary colic, blockage by a gallstone of the common bile duct or cystic duct
Devon colic or painters colic, a condition caused by lead poisoning
Horse colic, a potentially fatal condition experienced by horses, caused by intestinal displacement or blockage
Renal colic, a pain in the flank, characteristic of kidney stonesThe term is from Greek κολικός kolikos, "relative to the colon". References


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