They have been classified into the following types:: 596

Epidermolysis bullosa simplex
Epidermolysis bullosa simplex (EBS) is a form of EB that causes blisters at the site of rubbing. It typically affects the hands and feet, and is typically inherited in an autosomal dominant manner, affecting the keratin genes KRT5 and KRT14. Therefore, there is a failure in keratinization, which affects the integrity and the ability of the skin to resist mechanical stresses. Junctional epidermolysis bullosa
Junctional epidermolysis bullosa (JEB) is an inherited disease affecting laminin and collagen. This disease is characterized by blister formation within the lamina lucida of the basement membrane zone: 599  and is inherited in an autosomal recessive manner. It also presents with blisters at the site of friction, especially on the hands and feet, and has variants that can occur in children and adults. Less than one person per million people is estimated to have this form of EB. Dystrophic epidermolysis bullosa
Dystrophic epidermolysis bullosa (DEB) is an inherited variant affecting the skin and other organs. DEB is caused by genetic defects (or mutations) within the human COL7A1 gene encoding the protein type VII collagen (collagen VII). DEB-causing mutations can be either autosomal dominant or autosomal recessive. Epidermis bullosa pruriginosa and albopapuloid epidermolysis bullosa (Pasinis disease) are rare subtypes of this disease. Other genetic
Epidermolysis bullosa acquisita
Acral peeling
Pathophysiology
The human skin consists of two layers: an outermost layer called the epidermis and a layer underneath called the dermis.
On March 1, 2019, heavyweight boxer Luis Ortiz was named an honorary ambassador for the EB community by the EB Research Partnership. Ortizs daughter, Lismercedes, was born with EB. Movies
The condition was brought to public attention in 2004 in the UK through the Channel 4 documentary The Boy Whose Skin Fell Off, chronicling the life and death of Jonny Kennedy, an Englishman with EB. In the United States, the same could be said of the HBO documentary My Flesh and Blood from 2003. Additionally, the film Butterfly Girl follows Abigail Evans with the disease. In Canada, The Sports Networks award-winning documentary on Jonathan Pitre led to extensive coverage on the boys disease, treatment, and death. Other names
Other terms used to describe those affected include "butterfly children" as the skin is fragile as a butterflys wings, "cotton wool babies", or "crystal skin children". References
External links

GeneReviews/NCBI/UW/NIH entry on Epidermolysis Bullosa Simplex
Questions and Answers about Epidermolysis Bullosa - US National Institute of Arthritis and Musculoskeletal and Skin Diseases