Esophageal squamous cell carcinoma risk is also increased; therefore, it is considered a premalignant condition. Epidemiology
PVS is an extremely rare condition, though its exact prevalence is unknown. While it is becoming less common in developed countries, the condition is increasingly found in developing countries, particularly in Asia. However, it is very rarely seen in African countries, despite the relatively high prevalence of iron deficiency. History
The disease is named after two Americans working at the Mayo Clinic -- the physician Henry Stanley Plummer and the surgeon Porter Paisley Vinson. It is occasionally known as Paterson-Kelly or Paterson-Brown Kelly syndrome in the UK, after Derek Brown-Kelly and Donald Ross Paterson. However, Plummer–Vinson syndrome is still the most commonly used name. See also
List of hematologic conditions

References
External links
00325 at CHORUS
In the absence of heart failure, hypertension, with or without enlargement of the heart (left ventricular hypertrophy) is usually symptomless.Symptoms, signs and consequences of congestive heart failure can include:

Fatigue
Irregular pulse or palpitations
Swelling of feet and ankles
Weight gain
Nausea
Shortness of breath
Difficulty sleeping flat in bed (orthopnea)
Bloating and abdominal pain
Greater need to urinate at night
An enlarged heart (cardiomegaly)
Left ventricular hypertrophy and left ventricular remodeling
Diminished coronary flow reserve and silent myocardial ischemia
Coronary heart disease and accelerated atherosclerosis
Heart failure with normal left ventricular ejection fraction (HFNEF), often termed diastolic heart failure
Atrial fibrillation, other cardiac arrhythmias, or sudden cardiac deathHeart failure can develop insidiously over time or patients can present acutely with acute heart failure or acute decompensated heart failure and pulmonary edema due to sudden failure of pump function of the heart. Sudden failure can be precipitated by a variety of causes, including myocardial ischemia, marked increases in blood pressure, or cardiac arrhythmias. Diagnosis
Differential diagnosis
Other conditions can share features with hypertensive heart disease and need to be considered in the differential diagnosis. For example:
Coronary artery disease or ischemic heart diseases due to atherosclerosis
Hypertrophic cardiomyopathy
Left ventricular hypertrophy in athletes
Congestive heart failure or heart failure with normal ejection fraction due to other causes
Atrial fibrillation or other disorders of cardiac rhythm due to other causes
Sleep apnea

Prevention
Because there are no symptoms with high blood pressure, people can have the condition without knowing it.