A eunuch ( YOO-nək)  is a man who has been castrated. Throughout history, castration often served a specific social function.The earliest records for intentional castration to produce eunuchs are from the Sumerian city of Lagash in the 2nd millennium BCE. Over the millennia since, they have performed a wide variety of functions in many different cultures: courtiers or equivalent domestics, for espionage or clandestine operations, castrato singers, concubines, or sexual partners, religious specialists, soldiers, royal guards, government officials, and guardians of women or harem servants. Eunuchs would usually be servants or slaves who had been castrated to make them less threatening servants of a royal court where physical access to the ruler could wield great influence. Seemingly lowly domestic functions—such as making the rulers bed, bathing him, cutting his hair, carrying him in his litter, or even relaying messages—could, in theory, give a eunuch "the rulers ear" and impart de facto power on the formally humble but trusted servant. Similar instances are reflected in the humble origins and etymology of many high offices. Eunuchs supposedly did not generally have loyalties to the military, the aristocracy, or a family of their own (having neither offspring nor in-laws, at the very least). They were thus seen as more trustworthy and less interested in establishing a private "dynasty". Because their condition usually lowered their social status, they could also be easily replaced or killed without repercussion. In cultures that had both harems and eunuchs, eunuchs were sometimes used as harem servants.
Trimethoprims affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydropteroate synthase, an enzyme involved further upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly used in combination due to possible synergistic effects, and reduced development of resistance. This benefit has been questioned. History
Trimethoprim was first used in 1962. In 1972, it was used as a prophylactic treatment for urinary tract infections in Finland.Its name is derived from trimethyloxy-pyrimidine. See also
Tetroxoprim
Iclaprim

References
External links
"Trimethoprim". Drug Information Portal. U.S. National Library of Medicine.