Clostridium difficile Infection (CDI)
Rifaximin may also be a useful addition to vancomycin when treating patients with relapsing C. difficile infection. However, the quality of evidence of these studies was judged to be low. Because exposure to rifamycins in the past may increase risk for resistance, rifaximin should be avoided in such cases. Hepatic Encephalopathy (HE)
Rifaximin is used to prevent episodes of hepatic encephalopathy (changes in thinking, behavior, and personality caused by a build-up of toxins in the brain in people who have liver disease) in adults who have liver disease. It treats hepatic encephalopathy by stopping the growth of bacteria that produce toxins and that may worsen the liver disease. Although high-quality evidence is still lacking, it appears to be as effective as, or more effective than, other available treatments for hepatic encephalopathy (such as lactulose), is better tolerated, and may work faster. It prevents reoccurring encephalopathy and is associated with high patient satisfaction. People are more compliant and satisfied to take this medication than any other due to minimal side effects, prolonged remission, and overall cost. The drawbacks are increased cost, and lack of robust clinical trials for HE without combination lactulose therapy. Other uses
Other uses include treatment of: infectious diarrhea, small intestinal bacterial overgrowth, inflammatory bowel disease, and diverticular disease. It is effective in treating small intestinal bacterial overgrowth regardless of whether it is associated with irritable bowel syndrome or not.
Cause
Maffucci syndrome is most commonly caused by mutations in the IDH1 or IDH2 gene. Diagnosis
Differential diagnosis
In Ollier disease isolated enchondromas are present without the presence of hemangiomas. Management
Management entails careful examination and monitoring for malignant degenerations. Surgical interventions can correct or minimize deformities. See also
Ollier disease
Njolstad syndrome
List of cutaneous conditions
List of radiographic findings associated with cutaneous conditions

References
External links
Malfucci syndrome at Genetics Home Reference
Gupta N, Kabra M (February 2007). "Maffucci syndrome" (PDF). Indian Pediatr. 44 (2): 149–50. PMID 17351310.