vitamins and antioxidants
vasodilators
betahistine (Betaserc), an anti-vertigo drug
hyperbaric oxygen
rheologic agents that reduce blood viscosity (such as hydroxyethyl starch, dextran and pentoxifylline)
anti-inflammatory agents, primarily oral corticosteroids such as prednisone, methylprednisone
Intratympanic administration – Gel formulations are under investigation to provide more consistent drug delivery to the inner ear. Local drug delivery can be accomplished through intratympanic administration, a minimally invasive procedure where the ear drum is anesthetized and a drug is administered into the middle ear. From the middle ear, a drug can diffuse across the round window membrane into the inner ear. Intratympanic administration of steroids may be effective for sudden sensorineural hearing loss for some patients, but high quality clinical data has not been generated. Intratympanic administration of an anti-apoptotic peptide (JNK inhibitor) is currently being evaluated in late-stage clinical development. Epidemiology
General hearing loss affects close to 10% of the global population. In the United States alone, it is expected that 13.5 million Americans have sensorineural hearing loss. Of those with sensorineural hearing loss, approximately 50% are congenitally related. The other 50% are due to maternal or fetal infections, post-natal infections, viral infections due to rubella or cytomegalovirus, ototoxic drugs, exposure to loud sounds, severe head trauma, and premature births Of the genetically related sensorineural hearing loss cases, 75% are autosomal recessive, 15-20% autosomal dominant, and 1-3% sex-linked.
Triplegia is a medical condition characterized by the paralysis of three limbs. While there is no typical pattern of involvement, it is usually associated with paralysis of both legs and one arm—but can also involve both arms and one leg. Triplegia can sometimes be considered a combination of hemiplegia (paralysis of arm and leg of one side of the body) overlaying diplegia (paralysis of both legs), or as quadriplegia (paralysis of four limbs) with less involvement in one extremity.The condition is commonly associated with cerebral palsy, although conditions such as strokes can also lead to it. Triplegia has also been found to be due to an increase in intracranial pressure associated with hydrocephalus resulting from traumatic brain injury.A similar condition is triparesis, in which a person has paresis in three limbs, meaning that the limbs are very weak, but not completely paralyzed. In a case reported only due to its rarity, triplegia was reported following a surgical removal of the tonsils. An eight-year-old boy was sent to Willard Parker Hospital on August 12, 1929, and had been diagnosed with poliomyelitis. After an unrelated, and routine, tonsillectomy there was complete flaccid paralysis and loss of feeling in both the legs, right arm, and muscles in the trunk. == References ==