For example, reduced levels of neurosteroids may be seen in SLOS. These are lipids which take part in signaling within the brain, and must be produced within the brain itself. They are responsible for interacting with nuclear steroid receptors, and bind to neurotransmitter-gated ion channels. Specifically, they modulate the effects of GABA and NMDA receptors, resulting in calming effects, improved memory, and more. Thus, given that some characteristics of SLOS are the opposite of these effects (hyperactivity, anxiety), a reduction in neurosteroids could influence both neurological development and behaviour. Furthermore, as outlined above, cholesterol is an important aspect in Hedgehog signaling. With lower levels of cholesterol, hedgehog proteins would not undergo the necessary covalent modification and subsequent activation. This would result in impaired embryonic development, and may contribute to the observed physical birth defects in SLOS. One particular hedgehog signaling protein, sonic hedgehog (SHH), is important in the pattern of the central nervous system, facial features, and limbs. Other hedgehog proteins may be involved in the development of the genital tract and the skeleton.The altered sterol levels in SLOS are particularly relevant to cell membranes, which are made primarily of lipids. SLOS patients may show cell membranes with abnormal properties or composition, and reduced cholesterol levels greatly affect the stability and proteins of lipid rafts. Despite their structural similarity, 7DHC is unable to replace cholesterol in lipid rafts. In addition, a lack of cholesterol contributes to the increased fluidity of the cell membrane, and may cause abnormal granule secretions.
Italian Journal of Psychopathology, 17 (3): 265–276.http://www.gipsicopatol.it/issues/2011/vol17-3/02Spiti.pdf
Agoraphobia Without a History or Panic Disorder May Be Part of the Panic Disorder Syndrome. Journal of Nervous & Mental Disease, 190(9):624-630, September 2002. The Relationship of Agoraphobia and Panic in a Community Sample of Adolescents and Young Adults. External links

Anxiety Disorders Association of America Information for families, clinicians & researchers
Anxiety Disorders Association of Canada Registered Canadian non-profit organization, promotes prevention, treatment & management of anxiety disorders
ANXIETY UK (Formerly the National Phobics Society) Nationally registered charity in the UK; provides information, support & understanding
The Phobic Trust (Of New Zealand) Registered charitable trust in New Zealand; provides information about treatment, education & support to people with anxiety disorders
South African Depression and Anxiety group (National Charity) Counseling, mental health awareness programs: media & public speaking outreach & rural outreach initiatives
Agoraphobia without history of panic disorder at Curlie
Self help guide (NHS Direct)