Taking rifampicin usually causes certain bodily fluids, such as urine, sweat, and tears, to become orange-red in color, a benign side effect that nonetheless can be frightening if it is not expected. This may also be used to monitor effective absorption of the drug (if drug color is not seen in the urine, the patient may wish to move the drug dose farther in time from food or milk intake). The discolorization of sweat and tears is not directly noticeable, but sweat may stain light clothing orange, and tears may permanently stain soft contact lenses. Since rifampicin may be excreted in breast milk, breastfeeding should be avoided while it is being taken.Other adverse effects include:

Liver toxicity—hepatitis, liver failure in severe cases
Respiratory—breathlessness
Cutaneous—flushing, pruritus, rash, hyperpigmentation, redness and watering of eyes
Abdominal — nausea, vomiting, abdominal cramps, diarrhea
Flu-like symptoms—chills, fever, headache, arthralgia, and malaise. Rifampicin has good penetration into the brain, and this may directly explain some malaise and dysphoria in a minority of users. Allergic reaction—rashes, itching, swelling of the tongue or throat, severe dizziness, and trouble breathing

Chemical structure
Rifampicin is a polyketide belonging to the chemical class of compounds termed ansamycins, so named because of their heterocyclic structure containing a naphthoquinone core spanned by an aliphatic ansa chain.
The FDA also required manufacturers on all paracetamol containing products to issue a black box warning indicating the potential risk for severe liver injury and a warning highlighting potential for allergic reactions.On 22 August 2014, the Drug Enforcement Administration (DEA) announced that all hydrocodone combination products (HCPs) will be rescheduled from Schedule III to Schedule II of the Controlled Substances Act (CSA), effective on 6 October 2014. In 2010, more than 16,000 deaths were attributed to abuse of opioid drugs. Even though there are legitimate medical uses for HCPs, data suggest that a significant number of individuals misuse them. Popular culture
Vicodin is mentioned in songs such as Juice Wrlds "Already Dead" Eminems "Kill You", Blackbears "Sniffing Vicodin in Paris", Kendrick Lamars "A.D.H.D", Futures "Lay Up", Lupe Fiascos "Mural", Queens of the Stone Ages "Feel Good Hit of the Summer", A Winged Victory for the Sullens "Steep Hills of Vicodin Tears", Death Gripss "Anne Bonny" and The Wombats "Give Me a Try". Vicodin use is a central theme in the 2004–2012 medical TV drama House, in which the lead character Dr. Gregory House is addicted to the drug combination. Brand names
Brand names include Adol, Hycet, Lortab, Lorcet, Norco, and Vicodin among others. See also
Hydrocodone/aspirin
Hydrocodone/ibuprofen
Oxycodone/paracetamol

References
External links
"Acetaminophen mixture with Hydrocodone bitartrate". Drug Information Portal. U.S. National Library of Medicine. Vicodin U.S. Federal Regulations Archived 18 January 2017 at the Wayback Machine