The symptoms of acute nitrogen dioxide poisoning is non-specific and have a semblance with ammonia gas poisoning, chlorine gas poisoning, and carbon monoxide poisoning. The symptoms also resembles that of pneumonia or viral infection and other inhalational injuries but common symptoms includes rhinitis wheezing or coughing, conjunctivitis, headache, throat irritation and dyspnea which may progress to nasal fissures, ulcerations, or perforation. The patient is usually ill-appearing and presents with hypoxemia coupled with shallow rapid breathing. Therapy is supportive and includes removal from further nitrogen dioxide exposure. Systemic symptoms include fever and anorexia. Electrocardiography and chest radiography can help in revealing diffuse, bilateral alveolar infiltrates. Chest radiography may be used in diagnosis and the baseline could be established with pulmonary function testing. There is no specific laboratory diagnostic test for acute nitrogen dioxide poisoning but analysis of arterial blood gas level, 
methemoglobin level, complete blood count, glucose test, lactate threshold measurement and r peripheral blood smear may be helpful in the diagnosis of nitrogen dioxide poisoning. The determination of nitrogen dioxide in urine or tissue does not establish the diagnosis, and there are technical and interpretive problems with these tests. Chronic poisoning
Prolonged exposure to high levels of nitrogen dioxide can have an inflammatory effect that principally targets the respiratory tracts leading to chronic nitrogen dioxide poisoning which can occur within days or weeks after the threshold limit value is excessively exceeded.This condition causes fever, rapid breathing coupled with rapid heart rate, labored breathing and severe shortness of breath.
Keratoderma is a hornlike skin condition. Classification
The keratodermas are classified into the following subgroups:: 506

Congenital
Simple keratodermas
Diffuse palmoplantar keratodermas
Diffuse epidermolytic palmoplantar keratoderma
Diffuse nonepidermolytic palmoplantar keratoderma
mal de Meleda
Focal palmoplantar keratoderma
Striate palmoplantar keratoderma
Punctate palmoplantar keratoderma
Keratosis punctata palmaris et plantaris
Spiny keratoderma
Focal acral hyperkeratosis
Complex keratodermas
Diffuse palmoplantar keratoderma
Erythrokeratodermia variabilis
Palmoplantar keratoderma of Sybert
Olmsted syndrome
Naegeli–Franceschetti–Jadassohn syndrome
Focal palmoplantar keratoderma
Papillon–Lefèvre syndrome
Pachyonychia congenita type I
Pachyonychia congenita type II
Focal palmoplantar keratoderma with oral mucosal hyperkeratosis
Camisa disease
Ectodermal dysplasias
Cloustons hidrotic ectodermal dysplasia
Acrokeratotic poikiloderma
Dermatopathic pigmentosa reticularis
Syndromic keratodermas
Vohwinkel syndrome
Palmoplantar keratoderma associated with esophageal cancer
Palmoplantar keratoderma and spastic paraplegia
Naxos disease
Striate palmoplantar keratoderma, woolly hair, and left ventricular dilated cardiomyopathy
Keratitis-ichthyosis-deafness syndrome
Corneodermatosseous syndrome
Huriez syndrome
Oculocutaneous tyrosinemia
Cardiofaciocutaneous syndrome
Schöpf–Schulz–Passarge syndrome

Acquired
Acquired keratodermas
AIDS-associated keratoderma
Arsenical keratoses
Calluses
Climacteric keratoderma
Clavi (Corns)
Eczema
Human papillomavirus
Keratoderma blenorrhagicum
Lichen planus
Norwegian scabies
Paraneoplastic keratoderma
Psoriasis
Reactive arthritis
Secondary syphilis
Tinea pedis
Sézary syndrome
Tuberculosis verrucosa cutis
Drug-induced keratoderma

See also
Palmoplantar keratoderma
Skin lesion
List of cutaneous conditions
List of conditions caused by problems with junctional proteins

References


== External links ==