This may be done by using formate to reduce electron carriers and supply the ATP required in anabolic pathways inside of these synthetic autotrophs.E. coli have three native glycolytic pathways: EMPP, EDP, and OPPP. The EMPP employs ten enzymatic steps to yield two pyruvates, two ATP, and two NADH per glucose molecule  while OPPP serves as an oxidation route for NADPH synthesis. Although the EDP is the more thermodynamically favourable of the three pathways, E. coli do not use the EDP for glucose metabolism, relying mainly on the EMPP and the OPPP. The EDP mainly remains inactive except for during growth with gluconate. Catabolite repression
When growing in the presence of a mixture of sugars, bacteria will often consume the sugars sequentially through a process known as catabolite repression. By repressing the expression of the genes involved in metabolizing the less preferred sugars, cells will usually first consume the sugar yielding the highest growth rate, followed by the sugar yielding the next highest growth rate, and so on. In doing so the cells ensure that their limited metabolic resources are being used to maximize the rate of growth. The well-used example of this with E. coli involves the growth of the bacterium on glucose and lactose, where E. coli will consume glucose before lactose. Catabolite repression has also been observed in E. coli in the presence of other non-glucose sugars, such as arabinose and xylose, sorbitol, rhamnose, and ribose.
Hair loss may be present in the family, highlighting genetic causes. Causes
Causes of noncicatricial alopecia can be separated based on focal or diffuse hair loss:Diffuse:

Androgenetic alopecia: androgenic DHT leads to catagenic miniaturization of hair follicles. Diffuse alopecia areata: diffuse autoimmune destruction of hair follicles
Alopecia totalis: unknown but thought to be autoimmune
Telogen effluvium: emotional or physiologic stress
Anagen effluvium: cancer treatments such as radiation and alkylating agents
Dermatopathia pigmentosa reticularis: genetic autosomal dominant conditionFocal:

Alopecia areata: autoimmune destruction of hair follicles
Tinea capitis: fungal infection
Traction alopecia: pulling force applied to hair
Trichotillomania (Trichotillosis)

Diagnosis
There are a number of conditions that may cause non scarring hair loss and the first step is to determine the pattern: focal or diffuse. The next step is to identify if the hair loss is scarring or non scarring. A history and physical examination is necessary as this will provide clues to the ultimate diagnosis. It is essential to ask about the onset, observed pattern, hairstyles, family history, diet, and social history.Diffuse:

Androgenetic alopecia: history of gradual thinning of hair and characteristic pattern. Males start to lose hair in the front and temples while females lose hair at the top of the head
Diffuse alopecia areata: exclamation point hairs
Alopecia totalis: concomitant loss of facial and skull hair
Telogen effluvium: history of emotional or physiologic stress
Anagen effluvium: history cancer treatments such as radiation and alkylating agents
Dermatopathia pigmentosa reticularis: genetic autosomal dominant conditionFocal:

Alopecia areata: smooth and round lesions
Tinea capitis: black dots with broken hair strands, may see red, scaly lesions and swollen lymph nodes on the back of head.