This video is then shown to the child over a series of several weeks, and every time the child sees themself verbally answering the teacher/other adult, the tape is stopped and the child is given positive reinforcement.Such videos can also be shown to affected childrens classmates to set an expectation in their peers that they can speak. The classmates thereby learn the sound of the childs voice and, albeit through editing, have the opportunity to see the child conversing with the teacher. Mystery motivators
Mystery motivation is often paired with self-modeling. An envelope is placed in the childs classroom in a visible place. On the envelope, the childs name is written along with a question mark. Inside is an item that the childs parent has determined to be desirable to the child. The child is told that when they ask for the envelope loudly enough for the teacher and others in the classroom to hear, the child will receive the mystery motivator. The class is also told of the expectation that the child ask for the envelope loudly enough that the class can hear. Stimulus fading
Affected subjects can be brought into a controlled environment with someone with whom they are at ease and can communicate. Gradually, another person is introduced into the situation. One example of stimulus fading is the sliding-in technique, where a new person is slowly brought into the talking group.
Stimulation is somewhat more common than with other related antihistamines, and is especially common in the elderly. Common side effects include dry mouth, dizziness, drowsiness, constipation, urine retention, blurred vision, and headache. Its use in Parkinsons is especially limited by these factors.People with glaucoma, digestive problems such as peptic ulcers or bowel obstruction, or sphincter relaxation disorders, or with enlarged prostate, bladder problems, or myasthenia gravis, should not take this drug. Pharmacology
Orphenadrine is known to have this pharmacology:

Nonselective mACh receptor antagonist (anticholinergic, 58% as potent as atropine)  Various monographs and package inserts, nursing manuals, journal articles and so forth have proposed the theory that this anticholinergic (atropine-like) activity, NMDA antagonism and possible local anaesthetic and miscellaneous analgesic effects may be the reason for orphenadrines efficacy against muscle and other pain. These reasons are behind the use of orphenadrine and other drugs of a number of types which are used with paracetamol, aspirin, naproxen, and similar agents with or without opioid analgesics to more effectively manage pain of various types. H1 receptor antagonist (antihistamine)
NMDA receptor antagonist (Ki value of 6.0 ± 0.7 μM, one hundred times less potent than phencyclidine, which binds with a Ki of 59 nM)
NDRI (norepinephrine and dopamine reuptake inhibitor)
Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker
HERG potassium channel blocker

History
George Rieveschl was a professor of chemistry at the University of Cincinnati and led a research program working on antihistamines. In 1943, one of his students, Fred Huber, synthesized diphenhydramine.