Acute mania
As for its efficacy in the treatment of acute mania, a recent meta-analysis showed that it produces comparatively small improvements in manic symptoms in patients with acute mania and mixed episodes than most other antipsychotic drugs (with the exception of ziprasidone) such as risperidone and olanzapine. Drop-out rates (in clinical trials) were also unusually high with asenapine. According to a post-hoc analysis of two 3-week clinical trials it may possess some antidepressant effects in patients with acute mania or mixed episodes. Adverse effects
Adverse effect incidenceVery common (>10% incidence) adverse effects include:

SomnolenceCommon (1-10% incidence) adverse effects include:

Weight gain
Increased appetite
Extrapyramidal side effects (EPS; such as dystonia, akathisia, dyskinesia, muscle rigidity, parkinsonism)
Sedation
Dizziness
Dysgeusia
Oral hypoaesthesia
Increased alanine aminotransferase
FatigueUncommon (0.1-1% incidence) adverse effects include:

Hyperglycaemia — elevated blood glucose (sugar)
Syncope
Seizure
Dysarthria
sinus bradycardia
Bundle branch block
QTc interval prolongation (has a relatively low risk for causing QTc interval prolongation.)
Phoria are an English art rock band based in Brighton, consisting of Trewin Howard, Ed Sanderson, Jeb Hardwick, James "Cheese" Cheeseman, and Seryn Burden. Phoria released their debut EP, Yourself Still, in 2010, followed by Bloodworks (2013) and Display (2014). The records earned the band international critical and popular acclaim. The bands first full-length album, Volition, was released on 3 June 2016. Their second album, Caught a Black Rabbit, came out on 13 November 2020. Biography
Phoria members Trewin, Jeb and Ed went to primary as school together in Salisbury, where they learned cello, classical guitar, and violin respectively. As friends, they spent their youth making music together before leaving for university in 2005. Jeb and Ed both attended the University of Southampton. Ed continued to study music, specialising in violin and piano. Jeb studied for a sociology degree, though spent much of his time experimenting with music and visual arts. Trewin attended the Dartington College of Arts in Devon. He  had initially enrolled on as fine arts course but was soon drawn back to music. Having completed their studies, Trewin, Ed, and Jeb returned to Salisbury and took full time jobs. Jebs included a brief spell as an insurance agent. Ed, with a passion for acting, took large but unfulfilling parts in a series of niche-market films. It was not long before the three of them realised that their future lay elsewhere, and moved to Brighton to start their musical careers.