Acceptable empiric regimens include, but are not limited to, the following . :
•Ampicillin plus gentamicin (or amikacin) plus metronidazole
•Ampicillin plus gentamicin (or amikacin) plus clindamycin
•Ampicillin plus an expanded-spectrum cephalosporin (eg, cefotaxime [where available], ceftazidime, or cefepime) plus metronidazole
•Monotherapy with piperacillin-tazobactam
•Monotherapy with meropenem
Vancomycin should be included in the regimen (ie, replacing ampicillin or added to monotherapy) in centers where there is a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) or ampicillin-resistant enterococcal infections. Centers with significant gentamicin resistance patterns should consider amikacin in place of gentamicin. We do not recommend the use of oral aminoglycosides because this treatment can result in the development of resistant bacterial strains, and has not been shown to be more beneficial than standard care. Other clostridial toxemias
Leukemia patients, cancer chemotherapy recipients and others suffering from suppressed white blood cells (neutropenia) can be afflicted by a similar syndrome, neutropenic enterocolitis, in which the cecum is targeted by Clostridium septicum in much the same way. In neonatal intensive-care units, the syndrome of neonatal necrotizing enterocolitis may be caused in a similar way by C. perfringens, C. butyricum, and C. difficile, but this has not been proved. See also
Protein poisoning refers to a different diet-induced phenomenon. References


== External links ==
The term "chemical cosh"
The term "chemical cosh" (a club) is sometimes used popularly for a strong sedative, particularly for:

widespread dispensation of antipsychotic drugs in residential care to make people with dementia easier to manage. use of methylphenidate to calm children with attention deficit hyperactivity disorder, though paradoxically this drug is known to be a stimulant. See also Antipsychotic controversy

Types of sedatives
Therapeutic use
Doctors and veterinarians often administer sedatives to patients in order to dull the patients anxiety related to painful or anxiety-provoking procedures. Although sedatives do not relieve pain in themselves, they can be a useful adjunct to analgesics in preparing patients for surgery, and are commonly given to patients before they are anaesthetized, or before other highly uncomfortable and  invasive procedures like cardiac catheterization, colonoscopy or MRI. Risks
Sedative dependence
Some sedatives can cause psychological and physical dependence when taken regularly over a period of time, even at therapeutic doses. Dependent users may get withdrawal symptoms ranging from restlessness and insomnia to convulsions and death. When users become psychologically dependent, they feel as if they need the drug to function, although physical dependence does not necessarily occur, particularly with a short course of use. In both types of dependences, finding and using the sedative becomes the focus in life. Both physical and psychological dependence can be treated with therapy. Misuse
Many sedatives can be misused, but barbiturates and benzodiazepines are responsible for most of the problems with sedative use due to their widespread recreational or non-medical use.