Interactions
Interactions with other drugs:

Antidepressants (e.g. Elavil, Prozac)
Monoamine oxidase inhibitors (e.g. Nardil, Parnate)
Opioid analgesics
Sedatives (e.g. Ambien, Sonata)Diarrhea that is caused by some antibiotics such as cefaclor, erythromycin or tetracycline can worsen. Toxicity
It may cause serious health problems when overdosed. Signs and symptoms of adverse effects may include any or several of the following: convulsions, respiratory depression (slow or stopped breathing), dilated eye pupils, nystagmus (rapid side-to-side eye movements), erythema (flushed skin), gastrointestinal constipation, nausea, vomiting, paralytic ileus, tachycardia (rapid pulse), drowsiness and hallucinations. Symptoms of toxicity may take up to 12 hours to appear. Treatment of overdose must be initiated immediately after diagnosis and may include the following: ingestion of activated charcoal, laxative and a counteracting medication (narcotic antagonist). Mechanism of action
Diphenoxylate is anti-diarrheal and atropine is anticholinergic. A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage. Atropine has no anti-diarrheal properties, but will cause tachycardia when overused. The medication diphenoxylate works by slowing down the movement of the intestines. In some cases it has been shown to ease symptoms of opiate withdrawal. History
Diphenoxylate was developed in 1954 as part of US Navy and CIA-funded research on nonaddictive substitutes for codeine. Society and culture
Names
The UK British Approved Name (BAN) generic name for diphenoxylate and atropine is co-phenotrope.As of 2018, the combination drug is marketed in the US and some other countries under the following brands: Atridol, Atrolate, Atrotil, Co-Phenotrope, Dhamotil, Dimotil, Intard, Logen, Lomanate, Lomotil, Lonox, and Reasec.
Legal status
In the United States, it is classified as a Schedule V controlled substance by federal law, and is available only for a medical purpose. References
External links
"Atropine sulfate mixture with diphenoxylate hydrochloride". Drug Information Portal. U.S. National Library of Medicine.