Thallium figures prominently in the 1995 film The Young Poisoners Handbook, a dark comedy loosely based on the life of Graham Frederick Young. In Big Nothing, Josie is the Wyoming Widow; a murderer who befriended men and killed them with whiskey laced with highly concentrated thallium. In the 2007 episode "Whatever It Takes" of House, a character uses thallium to poison a patient to mimic the effects of polio, then appear to cure it with ultra-high doses of vitamin C.
In the NCIS episode "Dead Man Walking" (2007), thallium-laced cigars are used to murder a Naval officer. "Page Turner", a 2008 episode of CSI: NY, has radioactive thallium poisoning as its central theme. In the 2010 film Edge of Darkness, thallium is used to poison both the main character and his daughter. In the 2015 James Bond film Spectre, the organisation of the same name used thallium to poison Mr. White by lacing his mobile phone with it. In Season 3 of Royal Pains, the mysterious German billionaire Boris Kuester von Jurgens-Ratenicz was poisoned by thallium added to his pools water. In Drop Dead Diva episode "Ashes to Ashes", thallium was used to murder a clients husband, affecting the client when she ate the cremation remains. In the 2016 TVB drama Two Steps From Heaven, thallium was used to poison Bosco Wongs character. In S6:E10 of the Father Brown Series, Hercule Flambeaus wife poisons Father Brown with thallium in order to induce Flambeau to exchange a religious relic for her giving Brown the antidote.
Similarly to oral administration of estradiol, but in contrast to the vaginal and transdermal routes, the ratio of estradiol to estrone is decreased with sublingual administration of either estradiol valerate or estradiol. Intramuscular injection
In contrast to oral administration, the bioavailability of estradiol valerate is complete (i.e., 100%) via intramuscular injection. Due to the far greater bioavailability of intramuscular estradiol valerate relative to oral, the former is substantially stronger (in terms of potency) than the latter. As an example, a single 4 mg intramuscular injection is said to be approximately equivalent to 2 mg/day of the medication administered orally over the course of 3 weeks. Estradiol valerate, when given intramuscularly in oil, has a relatively long duration due to the formation of an intramuscular depot from which the medication is slowly released and absorbed. Upon intramuscular injection of estradiol valerate in an oil solution, the solvent (i.e., oil) is absorbed, and a primary microcrystalline depot is formed within the muscle at the site of injection. In addition, a secondary depot may also be formed in adipose tissue. The slow release of estradiol valerate is caused by the increased lipophilicity of the medication, which in turn is due to its long fatty acid valeric acid ester moiety. The elimination half-life of estradiol valerate in oil by intramuscular injection (brand names Estradiol-Depot 10 mg, Progynon Depot-10) is about 3.5 days, with a range of 1.2 days to 7.2 days in different individuals.