Severe sickle cell crises, in some cases resulting in death, have been associated with the use of filgrastim in patients with sickle cell disorders. Interactions
Increased hematopoietic activity of the bone marrow in response to growth factor therapy has been associated with transient positive bone imaging changes; this should be considered when interpreting bone-imaging results. Mechanism of action
G-CSF is a colony stimulating factor which has been shown to have minimal direct in vivo or in vitro effects on the production of other haematopoietic cell types. Neupogen (filgrastim) is the name for recombinant methionyl human granulocyte colony stimulating factor (r-metHuG-CSF). Society and culture
Biosimilars
In 2015, Sandozs filgrastim-sndz (trade name Zarxio), obtained the approval of the U.S. Food and Drug Administration (FDA) as a biosimilar. This was the first product to be passed under the Biologics Price Competition and Innovation Act of 2009 (BPCI Act), as part of the Affordable Care Act. Zarxio was approved as a biosimilar, not as an interchangeable product, the FDA notes. And under the BPCI Act, only a biologic that has been approved as an "interchangeable" may be substituted for the reference product without the intervention of the health care provider who prescribed the reference product.
Flashing may refer to:

Technology
Firmware#Flashing, overwriting an EEPROM module in a device
BIOS flashing, overwriting a BIOS image
Flashing (cinematography), a technique that desaturates the color so that one sees more in shadowed areas
Flashing (weatherproofing), construction material used to prevent the passage of water around objects
Flash evaporation, causing evaporation by lowering a fluids pressure below its vapour pressure
Flashing light, such as a light bulb or computers cursor
Flash (manufacturing), excess material attached to a moulded product which must usually be removed

Other
Flashing (horse)
Flashing, a 1981 album by Himiko Kikuchi
Exhibitionism, sexual body exposure
Indecent exposure, inappropriate public nudity
Headlight flashing, to alert other drivers
Facing (retail), moving shelved products to the front

See also
Flash (disambiguation)