This led in 1976 to the development and introduction of Progestasert, a progesterone-containing product and the first progestogen-containing IUD. Unfortunately, the product had various problems that limited its use. These included a short duration of efficacy of only one year, a high cost, a relatively high 2.9% failure rate, a lack of protection against ectopic pregnancy, and difficult and sometimes painful insertions that could necessitate use of a local anesthetic or analgesic. As a result of these issues, Progestasert never became widely used, and was discontinued in 2001. It was used mostly in the United States and France while it was marketed. Transdermal and topical
A topical gel formulation of progesterone, for direct application to the breasts as a local therapy for breast disorders such as breast pain, was introduced under the brand name Progestogel in Europe by 1972. No transdermal formulations of progesterone for systemic use have been successfully marketed, in spite of efforts of pharmaceutical companies towards this goal. The low potency of transdermal progesterone has thus far precluded it as a possibility. Although no formulations of transdermal progesterone are approved for systemic use, transdermal progesterone is available in the form of creams and gels from custom compounding pharmacies in some countries, and is also available over-the-counter without a prescription in the United States. However, these preparations are unregulated and have not been adequately characterized, with low and unsubstantiated effectiveness.
Out may refer to:

Arts, entertainment, and media
Films
Out (1957 film), a documentary short about the Hungarian Revolution of 1956
Out (1982 film), an American film directed by Eli Hollander
Out (2002 film), a Japanese film based on the novel by Natsuo Kirino and directed by Hideyuki Hirayama
Out (2013 film), a Canadian short comedy film directed by Jeremy LaLonde
Out (2017 film), a Slovak film directed by György Kristóf
Out (2020 film), an American animated film produced by Pixar

Music
Out (jazz) or outside, an approach to jazz improvisation
OUT, a band produced by Adam Walton
OUT, a 1994 album by Nav Katze
Out (In Essence), a 1991 album by Fluke

Television
Out (miniseries), a 1978 British television crime drama starring Tom Bell
"Out" (Dark Angel), a television episode

Other uses in arts, entertainment, and media
Out (magazine), an LGBT fashion, entertainment, and lifestyle magazine
Out (novel), a 1997 novel by Natsuo Kirino
OUTeverywhere, a community website for LGBT people around the world

Sports and recreation
Out (baseball), a play which retires the batter or a base runner
Out (cricket), the loss of a wicket by a batsman; also known as "dismissal"
Out (poker), an unseen card which is expected to win a hand, if drawn
Out (route), a pattern run by a receiver in American football

Sexuality
Coming out, publicly revealing ones own LGBT status
Outing, publicly revealing someone elses LGBT status

Mathematics
Out(Fn), the outer automorphism group of a free group on n generators
Outer automorphism group, a quotient Out(G) of the automorphism group

Transport
Outwood railway station, West Yorkshire, National Rail station code

Other uses
Out, a procedure word in voice radio communication

See also
Outing (disambiguation)
Outside (disambiguation)
All pages with titles containing Out
All pages with titles beginning with Out