The positioning of this "sealing zone" appears to be mediated by integrins expressed on the osteoclast surface. With the sealing zone in place, the multinucleated osteoclast reorganizes itself. Developing the highly invaginated ruffled membrane apposing the resorption compartment allows massive secretory activity. In addition, it permits the vesicular transcytosis of the mineral and degraded collagen from the ruffled border to the free membrane of the cell, and its release into the extracellular compartment. This activity completes the bone resorption, and both the mineral components and collagen fragments are released to the general circulation. Regulation
Osteoclasts are regulated by several hormones, including parathyroid hormone (PTH) from the parathyroid gland, calcitonin from the thyroid gland,  and growth factor interleukin 6 (IL-6). This last hormone, IL-6, is one of the factors in the disease osteoporosis. Osteoporosis occurs when there is an imbalance between the bone resorption activities of osteoclasts and the bone formation activities of osteoblasts.Osteoclast activity is also mediated by the interaction of two molecules produced by osteoblasts, namely osteoprotegerin and RANK ligand. Note that these molecules also regulate differentiation of the osteoclast. Odontoclast
An odontoclast (/odon·to·clast/; o-don´to-klast) is an osteoclast associated with absorption of the roots of deciduous teeth. Alternate use of term
An osteoclast can also be an instrument used to fracture and reset bones (the origin is Greek osteon: bone and klastos: broken). To avoid confusion, the cell was originally termed osotoclast. When the surgical instrument went out of use, the cell became known by its present name.
Significance
Kerala state depends on migrant workers for the various jobs needed. The dependence on Migrant labourers in Kerala is found mainly in the field of construction. The city of Kollam and other places like Punalur, Paravur in Kollam district, Perumbavoor, Thrissur etc. are slowly becoming overwhelmed with a number of migrants from North India. The migrant labours in places like Kollam have started scoring top marks in literacy equivalent examination. So an institute for developing the unskilled domestic labours as well as migrant labourers has become an essential need in Kerala. The main aim behind this institute is to train masons to upgrade their skills and get a certification from the Britain-based organisation City and Guilds.The flagship project of KASE is the Centre of Excellence in Construction and Infrastructure by the name Indian Institute of Infrastructure and Construction (IIIC). Established in a 9-acre state-of the-art campus at Chavara, Kollam District, Kerala, the objectives of IIIC are broadly to:

Establish a world class Skill Centre, as centre of excellence, for imparting international quality skill sets to the personnel in construction industry of all cadres, right from the labourers to the top managerial personnel under three major categories viz., technician, supervisory and managerial categories. Maximize the reach of the Skill Centre in terms of capacity intake as well as sub sectors covered and the area of reach.