However, the valganciclovir patent was rejected by the Indian Patent Office in 2010, although Roche may appeal the rejection. Names
Also known as Cymeval, Valcyt, Valixa, Darilin, Rovalcyte, Patheon, and Syntex. References
External links
"Valganciclovir". Drug Information Portal. U.S. National Library of Medicine.
Signs due to hyperactivity of stomach and intestines:
Poor feeding and sucking reflex
Vomiting
Diarrhea
Signs due to hyperactivity of autonomous nervous system:
Fever
Sweating
Yawning, stuffy nose, and sneezing
Fast breathing

Causes
The drugs involved can include opioids, selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitor (SNRIs), tricyclic antidepressants (TCAs), ethanol, and benzodiazepines. Opioids may be more likely to cause NAS than other substances due to an increase in its usage. Exposure to heroin and methadone claimed to be correlated with a 60 to 80% occurrence of neonatal withdrawal, whereas buprenorphine has been associated with a lower risk. Neonatal abstinence syndrome does not happen in prenatal cocaine exposure. Prematurity and exposure to other drugs may instead be the cause of symptoms.The main mechanistic pathway of prescribed and illicit substance-induced NAS is the hyperactivity of the central and autonomic nervous system and gastrointestinal tract There are several potential mechanisms and pathways that have been proposed, which includes the interaction between the neurotransmitters and lack of adequate expression of opioid receptors. However, the main pathophysiology of this syndrome remains unknown. Most of the opioid induced NAS are due to opioid exposure during pregnancy for pain relief, misuse, or abuse of prescribed opioids or other medication-assisted treatment of opioid use disorder. Diagnosis
The presence of withdrawal in the neonate can be confirmed by taking a detailed medical history from the mother.