Interestingly, histologists were able to identify hyaline bodies within the tissue framework of the GOC. It is encouraged that the histological identification of at least seven of these biological characteristics is required to accurately distinguish the presence of the GOC. Intraepithelial Hemosiderin
Pathologists have identified hemosiderin pigments that are considered unique to the GOC. The discovery of this pigment can be pivotal to the differentiation of the GOC from other lesions. The staining at the epithelium is due to the haemorrhaging of the lining. The cause of the haemorrhaging can be triggered by the type of treatment, cellular degradation, or structural deformation inflicted during GOC expansion. Examination of the GOC tissue section indicated that red blood cells from the intraluminal space had combined with the extracellular constituents. This process is carried out through transepithelial elimination. This clinical procedure is beneficial to confirm the benign or malignant nature of the GOC. Immunocytochemistry
The examination of cytokeratin profiles is deemed useful when observing the differences between the GOC and the central MEC. These two lesions show individualised expression for cytokeratin 18 and 19. Past studies observed Ki-67, p53, and PCNA expression in common jaw cysts that shared similar characteristics. There was a lack of p53 expression found in radicular cysts. Similarly, Ki-67 was seen less in the central MEC compared to the other lesions, though this discovery is not essential to the process of differential diagnosis. Proliferating cell nuclear antigen readings were established to have no role in the differentiation process.
"Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case report: Central MEC arising from GOC". Pathology International. 68 (1): 31–35. doi:10.1111/pin.12609. PMID 29131467. S2CID 8932602. Neville, Brad W. (2016). "Cyst, Glandular Odontogenic". In Slootweg, Pieter (ed.). Dental and Oral Pathology. Encyclopedia of Pathology. Springer International Publishing. pp. 89–93. doi:10.1007/978-3-319-28085-1_677. ISBN 978-3-319-28084-4. Prabhu, Sudeendra; Rekha, K; Kumar, GS (2010). "Glandular odontogenic cyst mimicking central mucoepidermoid carcinoma". Journal of Oral and Maxillofacial Pathology. 14 (1): 12–5. doi:10.4103/0973-029X.64303. PMC 2996005. PMID 21180452. Momeni Roochi, Mehrnoush; Tavakoli, Iman; Ghazi, Fatemeh Mojgan; Tavakoli, Ali (1 July 2015). "Case series and review of glandular odontogenic cyst with emphasis on treatment modalities". Journal of Cranio-Maxillofacial Surgery. 43 (6): 746–750. doi:10.1016/j.jcms.2015.03.030. PMID 25971944. Patel, Govind; Shah, Monali; Kale, Hemant; Ranginwala, Amena (2014). "Glandular odontogenic cyst: A rare entity". Journal of Oral and Maxillofacial Pathology. 18 (1): 89–92. doi:10.4103/0973-029X.131922. PMC 4065455. PMID 24959044. Shah, AmishaA; Sangle, Amit; Bussari, Smita; Koshy, AjitV (2016). "Glandular odontogenic cyst: A diagnostic dilemma". Indian Journal of Dentistry. 7 (1): 38–43. doi:10.4103/0975-962X.179371. PMC 4836096. PMID 27134453. Shear, Mervyn; Speight, Paul, eds. (2007). "Glandular Odontogenic Cyst (Sialo-Odontogenic Cyst)". Cysts of the Oral and Maxillofacial Regions. pp. 94–99. doi:10.1002/9780470759769.ch7. ISBN 978-0-470-75976-9. == Further reading ==