Didanosine (ddI, DDI), sold under the brand name Videx, is a medication used to treat HIV/AIDS. It is used in combination with other medications as part of highly active antiretroviral therapy (HAART). It is of the reverse-transcriptase inhibitor class. Didanosine was first described in 1975 and approved for use in the United States in 1991. Adverse effects
The most common adverse events with didanosine are diarrhea, nausea, vomiting, abdominal pain, fever, headache, and rash. Peripheral neuropathy occurred in 21-26% of participants in key didanosine trials.Pancreatitis is rarely observed but has caused occasional fatalities, and has black box warning status. Other reported serious adverse events are retinal changes, optic neuritis and alterations of liver functions. The risk of some of these serious adverse events is increased by drinking alcohol. In February 2010, the United States Food and Drug Administration issued a statement that patients using didanosine (Videx) are at risk for a rare but potentially fatal liver disorder, non-cirrhotic portal hypertension. Drug interactions
A significant interaction has also been recorded with allopurinol, and administration of these drugs together should be avoided. Reduction in indinavir and delavirdine plasma levels have been shown to occur when administered simultaneously with didanosine; these drugs should be administered at different times. Ketoconazole, itraconazole, ciprofloxacin should be administered at a different time from didanosine due to interactions with the buffering agent. Administration with drugs with overlapping toxicity, such as zalcitabine and stavudine, is not recommended. Alcohol can exacerbate didanosines toxicity, and avoiding drinking alcohol while taking didanosine is recommended.
A mesenteric cyst (MeSH C04.182.473) is a cyst in the mesenterium, and is one of the rarest abdominal tumors, with approximately 822 cases reported since 1507. The incidence is between 1 per 100,000 to 1 per 250,000 hospital admissions.Tillauxs triad named after the French surgeon Paul Jules Tillaux can be seen in cases of mesenteric cyst. It consists of the following signs:
a fluctuating swelling near the umbilicus,
freely mobile in the direction perpendicular to the attachment of mesentry,
with a zone of resonance around the swelling.It is basically of two types :
1. Chylolymphatic most common type, thin wall, lined by flat endotheliun, clear chylous fluid present, separate blood vessels
2. Enterogenous-thick wall, lined by columnar, mucinous fluid present common blood supply


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