Dinutuximab beta also has these adverse effects.More than 25% of children taking these drugs experienced pain, fever, hives, vomiting, diarrhea, bone marrow suppression causing loss of platelets, red blood cells, white blood cells, and albumin, hypotension, electrolyte imbalance including low sodium, potassium, and calcium, elevated transaminases, infusion reactions, and capillary leak syndrome.Other common adverse effects include retention or urine for weeks to months after receiving the drugs, protein in urine, blurred vision or dilated pupils, infections, edema, high blood pressure, bleeding that wont stop, tachycardia, and weight gain. Pharmacology
Dinutuximab and dinutuximab beta each work by binding to GD2, a glycolipid found on cells originating from the neuroectoderm during prenatal development, including neurons in the central nervous system and in the peripheral nervous system. Neuroblastoma cells have this as well. When dinutuximab binds to any cell that has GD2, that cell is destroyed via cell-mediated cytotoxicity and complement-dependent cytotoxicity.In clinical trials of dinutuximab, the maximum plasma concentration was 11.5 mcg/mL; the mean steady state volume distribution was 5.4 L; the clearance rate was 0.21 L/day; and the average half-life was 10 days. Chemistry
Ch14.18 is a chimeric monoclonal antibody in which the variable heavy and light chain regions come from a mouse, with a human constant region for the heavy chain IgG1 and light chain kappa.The version of dinutuximab made by United Therapeutics, and marketed under the brand name Unituxin, is manufactured via industrial fermentation using a murine myeloma cell line, SP2/0.
Lace bite is an irritation of the tibialis anterior and toe extensor tendons. The medical term for the condition is "tibialis anterior tendinopathy." This irritation, felt on the front of the foot or ankle, is often experienced by ice hockey players and figure skaters. It is caused by friction between the tendon and tongue of the ice skate.Common symptoms of lace bite include:
Pain, tenderness, and swelling where the front of the ankle meets the foot
Discomfort with ankle motion, especially when pulling the foot up or turning it inward
A cracking sound when the front of the foot or ankle is moved or touchedTreatment options include adjusting tongue positioning, additional padding, alternative lacing, and placing an orthoplast between the leather of the boot and its padding. == References ==