Background
Human malaria is native to 97 countries and is the worlds most prevalent vector-borne disease with 212 million new cases in 2015. Any occurrences outside endemic countries are largely imported cases or less commonly malaria with no recent travel history.Airport malaria is defined as malaria acquired at or near an airport through the bite of an infected tropical Anopheles mosquito by a person who has no history of being exposed to the mosquitoes in their natural habitat. Malaria transmission in-flight or on a stop-over is not considered airport malaria. Causes
Although most imported malaria is due to travel by infected humans, airport malaria is specifically caused by the transmission of malaria parasites to a human through the bite of a malaria infected mosquito that has travelled by aircraft on an international flight from a country where malaria is usually found to a country where malaria is usually not found. It occurs at or around the vicinity of the airport. Very few mosquitoes however enter aircraft and of those that do, less than 5% are likely to carry malaria. Of the four different species of the protozoan parasite Plasmodium; Plasmodium falciparum, Plasmodium malariae, Plasmodium vivax and Plasmodium ovale, airport malaria is most commonly the falciparum and less commonly the vivax type. These can only be transmitted by female Anopheles mosquitoes, which bite mainly between dusk and dawn.Five infection pathways have been described: inside the aircraft, inside the airport, around the airport, far from the airport and from luggage.
Children with CDD can experience a loss of expressive and receptive language skills, social and self-care skills, play skills, and/or motor skills. Regression commonly occurs at around 3 or 4 years old, but after at least two years of normal development and before age 10. Rett Syndrome
Rett syndrome is a neurodevelopmental disorder caused by a genetic mutation. It occurs almost exclusively in girls. A child with Rett syndrome experiences a loss of previously had intentional hand skills, and can experience a loss of language skills. Children can also experience a loss of social skills and autism-like symptoms. The regression typically occurs between 1–4 years of age. Landau-Kleffner Syndrome
Landau-Kleffner syndrome is a form of epilepsy associated with a loss of language skills. Those with LKS lose their ability to understand spoken language and to verbally express themselves. LKS typically has an onset of between the ages of 2 and 8 years old. Neuro-degenerative diseases
Neuro-degenerative diseases (disorders like Batten disease) can result in a child losing previously acquired motor, language, and speech skills. Signs and symptoms
Children with developmental regression lose developmental milestones they have previously gained. These can be motor, social, or language skills. The loss of motor skills could include loss of the ability to purposefully use hands, loss of the ability to feed oneself, loss of the ability to walk, loss of the ability to bathe oneself, and loss of the ability to dress oneself.