This treatment may be necessary as globozoospermic sperm can be less likely to activate the oocyte, an important stage in fertilisation.The treatment options currently available focus on overcoming the prognosis of infertility which is associated with globozoospermia. So far there are no treatment options to prevent or cure globozoospermia. Research
Research into globozoospermia is aimed at improving understanding of its cause and developing treatment options. Genetics
The observation has been made many times that globozoospermia arises in siblings which points towards an underlying genetic cause. Recent progress has been made into determining what genes could be implicated in this pathology, with the previously mentioned genes being found to play a role. There are more genes which have been shown to be mutated in globozoospermia in mice, but these are yet to be connected to the human disease process. Examples of these include Gopc, Hrb and Csnka2. There are thousands of genes which guide the process of spermatogenesis, and knowing how they’re involved in globozoospermia is an important current area of research. ICSI
The development of intracytoplasmic sperm injection made conception a possibility for patients with a variety of male infertility conditions, including globozoospermia. However, fertility rates with this approach are still low, and research is ongoing into how this can be improved.It has been found that treating globozoospermia with ICSI along with oocyte activation by calcium ionophore (an ion carrier used to increase intracellular calcium is more likely to result in conception than ICSI alone.
It has also shown efficacy with rosacea, ocular rosacea which also presents as dry eyes for patients with co-occurrence with small intestinal bacterial overgrowth (SIBO). Special caution
Patients should avoid Rifaximin usage if they are allergic to Rifabutin, Rifampin and Rifapentine. It may cause attenuated vaccines (such as typhoid vaccine) to not work well. Health care professionals should be informed about its usage before having any immunizations. Pregnant or breastfeeding women should avoid taking it as it is a pregnancy category C drug and can harm the foetus. Cautious use is required in individuals with cirrhosis of the liver who have a Child-Pugh score of class C severity. Side effects
Rifaximin has an excellent safety profile due to its lack of systemic absorption. Clinical trials did not show any serious adverse events while using the drug. There were no deaths while using it in the clinical trials.The most common side effects includes nausea, stomach pain, dizziness, fatigue, headaches, muscle tightening and joint pain. It may also cause reddish discoloration of urine.The most serious side effects of Rifaximin are:

Clostridium difficile-associated diarrhea (CDAD)
Drug-resistant bacterial superinfection
Severe allergic reactions including hives, rashes and itching

Interactions
As Rifaximin is not significantly absorbed from the gut, the great majority of these drug interactions are negligible in people with healthy liver function, so healthcare providers usually do not worry about drug interactions unless liver impairment is present. It may decrease the effectiveness of warfarin, a commonly prescribed anticoagulant, in people with liver problems.