Research Direction
Well-designed clinical trials for stroke treatment in neonates are lacking  Recent clinical trials show that therapeutic intervention by brain cooling beginning up to 6 hours after perinatal asphyxia reduces cerebral injury and may improve outcome in term infants, indicating cell death is both delayed and preventable Pancaspase inhibition and Casp3-selective inhibition have been found to be neuroprotective in neonatal rodents with models of neonatal brain injury, which may lead to pharmacological intervention  In a study done by Chauvier, et al., it is suggested that a Caspase inhibitor, TRP601, is a candidate for neuroprotective strategy in prenatal brain injury conditions. They found a lack of detectable side effects in newborn rodents and dogs. This may be a useful treatment in combination with hypothermia.MRI has proven valuable for defining brain injury in the neonate, but animal models are still needed to identify causative mechanisms and to develop neuroprotective therapies. In order to model human fetal or neonatal brain injury, one needs a species in which a similar proportion of brain development occurs in utero, the volume of white to grey matter is similar to the human brain, an insult can be delivered at an equivalent stage of development, the physiological outcome of the insult can be monitored, and neurobehavioral parameters can be tested.
They have shown that approximately 1 in 3 cattle farms and 1 in 4 sheep or goat farms are infected. However, there are wide variations between studies and countries. In China, Iran, Great Britain, Germany, Hungary, the Netherlands, Spain, the US, Belgium, Denmark, Croatia, Slovakia, the Czech Republic, Serbia, Slovenia and Jordan, for example, it has been shown that more than 50% of cattle herds were infected with Q fever.Infected animals shed the bacteria by three routes: genital discharge, faeces and milk. Excretion is greatest at the time of parturition or abortion and placentas and aborted fetuses are the main sources of bacteria, particularly in goats. As Coxiella burnetii is small and resistant in the environment, it is easily airborne and can be transmitted from one farm to another, even if it is several kilometres away. Control
Biosecurity measures
Based on the epidemiological data, biosecurity measures can be derived:
The spread of manure from infected farm should be avoided in windy conditions
The level of hygiene must be very high during parturition and fetal annexes and fetuses must be collected and destroyed as soon as possible

Medical measures
A vaccine for cattle and goats exists. It reduces clinical expression such as abortions and decreases excretion of the bacteria by the animals leading to control of Q fever in herds.In addition, vaccination of herds against Q fever has been shown to reduce the risk of human infection. References
External links

Q fever at the CDC
Coxiella burnetii genomes and related information at PATRIC, a Bioinformatics Resource Center funded by NIAID