Amoxapine is also a weak GlyT2 blocker, as well as a weak (Ki = 2.5 μM, EC50 = 0.98 μM) δ-opioid receptor partial agonist.7-Hydroxyamoxapine, a major active metabolite of amoxapine, is a more potent dopamine receptor antagonist and contributes to its neuroleptic efficacy, whereas 8-hydroxyamoxapine is a norepinephrine reuptake inhibitor but a stronger serotonin reuptake inhibitor and helps to balance amoxapines ratio of serotonin to norepinephrine transporter blockade. Pharmacokinetics
Amoxapine is metabolised into two main active metabolites: 7-hydroxyamoxapine and 8-hydroxyamoxapine. Where:
- t1/2 is the elimination half life of the compound. - tmax is the time to peak plasma levels after oral administration of amoxapine. - CSS is the steady state plasma concentration. - protein binding is the extent of plasma protein binding. - Vd is the volume of distribution of the compound. Society and culture
Brand names
Brand names for amoxapine include (where † denotes discontinued brands):
Adisen (KR)
Amolife (IN)
Amoxan (JP)
Asendin† (previously marketed in CA, NZ, US)
Asendis† (previously marketed in IE, UK)
Défanyl (FR)
Demolox (DK†, IN, ES†)
Oxamine (IN)
Oxcap (IN)

See also
Loxapine


== References ==
Early infection is characterized by a well demarcated, usually pale, skin lesion which has lost its hair, and there may be many of these lesions if the infection is more severe (most commonly found on the cooler parts of the body such as the elbows, knees, fingers, or scrotum, as the bacteria thrive in cooler environments). This early presentation is the same for both tuberculous and lepromatous forms of leprosy as they are a spectrum of the same disease (lepromatous being the more contagious and severe form in patients with impaired Th1 response). Disease progression is extremely slow, and signs of infection may not appear for years.Family members of those with the disease, and especially children, are most at risk. The disease is believed to be spread through respiratory droplets in close quarters like its relative Mycobacterium tuberculosis, and similarly requires extended exposure to an individual in most situations, so outsiders and healthcare workers are normally not infected (except with the most infective individuals such as those in the most progressed lepromatous forms, as those patients have the highest bacterial loads). See also
Tuberculoid leprosy
Diffuse leprosy of Lucio and Latapí

References


== External links ==