This was noted in human tissue in 1974 and in animal models in 1985. In TLE, the sprouting mossy fibres are larger than in the normal brain and their connections may be aberrant. Mossy fibre sprouting continues from one week to two months after injury. : 416–431 Aberrant mossy fibre sprouting may create excitatory feedback circuits that lead to temporal lobe seizures. This is evident in intracellular recordings. Stimulation of aberrant mossy fibre areas increases the excitatory postsynaptic potential response.However, aberrant mossy fiber sprouting may inhibit excitatory transmission by synapsing with basket cells which are inhibitory neurons and by releasing GABA and neuropeptide Y which are inhibitory neurotransmitters. Also, in animal models, granule cell hyper-excitability is recorded before aberrant mossy fibre sprouting has occurred. Diagnosis
The diagnosis of temporal lobe epilepsy can include the following methods: Magnetic resonance imaging (MRI), CT scans, positron emission tomography (PET), EEG, and magnetoencephalography. Imaging
CT scan is useful as the emergency situations when the suspected cause of epilepsy is due to conditions such as intracerebral haemorrhage, or brain abscesses, or when MRI imaging is not readily available or there is any contraindications to MRI such as the presence of cardiac pacemakers or cochlear implants in the subjects body. CT scan also detect some abnormal calcifications in the brain that is characteristic of diseases such as tuberous sclerosis and Sturge-Weber syndrome.
Tight hamstrings and weak thigh muscles, required to stabilize the knee, risk development of runners knee. Food
The thigh meat of some animals such as chicken and cow is consumed as food in many parts of the world. Society and culture
Western societies generally tolerate clothing that displays thighs, such as short shorts and miniskirts. Beachwear and many athleisure styles often display thighs as well. Professional dress codes may require covering up bare thighs. Many Islamic countries disapprove of or prohibit the display of thighs, especially by women. Strategic covering or display of thighs is used in popular fashion around the world, such as thigh-high boots and zettai ryoiki. Additional images

		
		
		
		
		


== References ==