Prevalence
According to OMIM, around 15-20 cases from 4 affected families with Wolfram-like syndrome have been described in medical lirerature. All of the families studied were European, both by ancestry and by nacionality, the countries said families originated from were Denmark, the Netherlands, France, and Sweden, respectively. History
The disorder was seemingly first described in 1940 by Samuelson et al, their patients were 4 members from a Swedish family with an apparently never-described-before combination of autosomal dominant sensorineural deafness and optic atrophy. Said family was later re-examined in 2011 by Rendtorff et al
In 2006, Eiberg et al. described 4 affected members from a 3-generation Danish family, said individuals showed a phenotype similar to that shown by patients with Wolfram syndrome, the pair of symptoms associated with the familys unique disorder was inherited following an autosomal dominant manner. All individuals had progressive hearing loss starting in childhood and optic atrophy with onset in either childhood or middle age. 3 out of the 4 individuals were found to have irregular glucose regulation, 1 had reduced glucose tolerance, another one was found to have diabetes which was previously undiagnosed, and yet another one of the patients was found to have decreased function of the pancreas beta cells. 1 out of the 4 individuals had a diagnosed anxiety disorder as well as a sleep disorder.
Wolfram-like syndrome is a rare autosomal dominant genetic disorder which shares some of the features shown by those affected with the autosomal recessive Wolfram syndrome. It is a type of WFS1-related disorder. Signs and symptoms
Individuals with this condition usually exhibit early-onset progressive hearing loss which starts around the age of 10 years old, early-onset optic atrophy which usually manifests in a persons mid teenage–late adulthood years of life, and adult-onset diabetes mellitus.Although rarely, psychiatric symptoms can also manifest in people with the condition, this group of symptoms consists of hallucinations, depression, anxiety, and sleep disorders.Psychosis and autism are sometimes seen as features of the disorder.Other symptoms include nephrocalcinosis, psychomotor delay, glaucoma, and megalocornea. Complications
The psychiatric features that may appear in patients with this condition, particularly depression, can cause a patient to be live in a constantly miserable state of mind, which can lead some patients to develop suicidal tendencies and, which can ultimately lead to making the decision of commiting suicide.