The presence of the inner oblique layer is distinct from other parts of the gastrointestinal tract, which do not possess this layer. Stomach contains the thickest muscularis layer consisting of three layers, thus maximum peristalsis occurs here. The inner oblique layer: This layer is responsible for creating the motion that churns and physically breaks down the food. It is the only layer of the three which is not seen in other parts of the digestive system. The antrum has thicker skin cells in its walls and performs more forceful contractions than the fundus. The middle circular layer: At this layer, the pylorus is surrounded by a thick circular muscular wall, which is normally tonically constricted, forming a functional (if not anatomically discrete) pyloric sphincter, which controls the movement of chyme into the duodenum. This layer is concentric to the longitudinal axis of the stomach. Auerbachs plexus (myenteric plexus) is found between the outer longitudinal and the middle circular layer and is responsible for the innervation of both (causing peristalsis and mixing).The outer longitudinal layer is responsible for moving the bolus towards the pylorus of the stomach through muscular shortening. To the outside of the muscularis externa lies a serosa, consisting of layers of connective tissue continuous with the peritoneum. Glands
The mucosa lining the stomach is lined with a number of these pits, which receive gastric juice, secreted by between 2 and 7 gastric glands. Gastric juice is an acidic fluid containing hydrochloric acid and the digestive enzyme pepsin.
A liver biopsy may be used, which is the most accurate diagnostic technique. The level of siderosis seen in a liver biopsy can be graded by severity. Treatment
Transfusional hemosiderosis is treated with a number of therapies. Venipuncture (phlebotomy) removes blood. Erythrocytapheresis filters red blood cells from the blood. Chelation therapy removes iron from the blood. This involves delivering iron chelating agents such as deferoxamine, deferiprone or deferasirox. If iron overload has caused damage to end-organs, this is generally irreversible and may require transplantation. Prognosis
Transfusion hemosiderosis can cause permanent damage to tissues that may lead to death. Tissue damage can remain even after chelation therapy. Outcomes are usually worse in patients who require blood transfusions compared to those who can have alternative therapies. Cardiomyopathy and cardiac arrhythmia are often a cause of death. Society
Ted DeVita died of transfusional iron overload from too many blood transfusions. See also
Hemosiderosis

References

Lu JP, Hayashi K (1994). "Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases". Pathol. Int. 44 (3): 194–9. doi:10.1111/j.1440-1827.1994.tb02592.x. PMID 8025661. S2CID 25357672.