Progressive supranuclear palsy (PSP) is a late-onset degenerative disease involving the gradual deterioration and death of specific volumes of the brain. The condition leads to symptoms including loss of balance, slowing of movement, difficulty moving the eyes, and cognitive impairment. PSP may be mistaken for other neurodegenerative diseases such as Parkinsons, frontotemporal dementia and Alzheimers. The cause of the condition is uncertain, but involves accumulation of tau protein within the brain. Medications such as levodopa and amantadine may be useful in some cases.PSP affects about six people per 100,000. The first symptoms typically occur at 60–70 years of age. Males are slightly more likely to be affected than females. No association has been found between PSP and any particular race, location, or occupation. Signs and symptoms
The initial symptoms in two-thirds of cases are loss of balance, lunging forward when mobilizing, fast walking, bumping into objects or people, and falls. Dementia symptoms are also initially seen in about one in five cases of frontotemporal dementia.Other common early symptoms are changes in personality, general slowing of movement, and visual symptoms. The most common behavioural  symptoms in patients with PSP include  apathy, disinhibition, anxiety, and dysphoria.Later symptoms and signs can include, but do not necessarily include dementia (typically including loss of inhibition and ability to organize information), slurring of speech, difficulty swallowing, and difficulty moving the eyes, particularly in the vertical direction.
Maceration  may refer to:

Maceration (food), in food preparation
Maceration (wine), a step in wine-making
Carbonic maceration, a wine-making technique
Maceration (sewage), in sewage treatment
Maceration (bone), a method of preparing bones
Acid maceration, the use of an acid to extract micro-fossils from rock
Maceration, in chemistry, the preparation of an extract by solvent extraction
Maceration, in biology, the mechanical breakdown of ingested food into chyme
Skin maceration, in dermatology, the softening and whitening of skin that is kept constantly wet
Maceration, in poultry farming, a method of chick culling