Following this, a similar phenotype was noted in patients with critical illness, tumors, and uremia.The alternative phenotype of type-2 thyroid allostasis was first predicted in 1968, when John W. Mason expected the concentrations of thyroid hormones to rise in situations of psychosocial stress. Masons postulate was later confirmed by numerous studies. See also
Thyroid storm

References
Further reading
McIver B, Gorman CA (February 1997). "Euthyroid sick syndrome: an overview". Thyroid. 7 (1): 125–32. doi:10.1089/thy.1997.7.125. PMID 9086580. == External links ==
Given the abnormalities of the microvasculature and other side effects of diabetes, these wounds take a long time to heal and require a specialized treatment approach for proper healing. As many as 75% of diabetic patients will eventually develop foot ulcers, and recurrence within five years is 70%. If not aggressively treated, these wounds can lead to amputations. It is estimated that every 30 seconds a lower limb is amputated somewhere in the world because of a diabetic wound. Amputation often triggers a downward spiral of declining quality of life, frequently leading to disability and death. In fact, only about one third of diabetic amputees will live more than five years, a survival rate equivalent to that of many cancers. Many of these lower extremity amputations can be prevented through an interdisciplinary approach to treatment involving a variety of advanced therapies and techniques, such as debridement, hyperbaric oxygen treatment therapy, dressing selection, special shoes, and patient education. When wounds persist, a specialized approach is required for healing. Pathophysiology
To heal a wound, the body undertakes a series of actions collectively known as the wound healing process. Diagnosis
A wound may be recorded for follow-up and observing progress of healing with different techniques which include:
Photographs, with subsequent area quantification using computer processing
Wound tracings on acetate sheets
Kundin wound gauge

Management
The overall treatment depends on the type, cause, and depth of the wound, and whether other structures beyond the skin (dermis) are involved. Treatment of recent lacerations involves examining, cleaning, and closing the wound.