Pharmacology
Mechanism of action
Like other members of the anthranilic acid derivatives (or fenamate) class of NSAIDs, it inhibits both isoforms of the enzyme cyclooxygenase (COX-1 and COX-2). This prevents formation of prostaglandins, which play a role in pain sensitivity, inflammation and fever, but also in hemostasis, kidney function, sustaining of pregnancy, and protection of the gastric mucosa. Pharmacokinetics
Mefenamic acid is rapidly absorbed from the gut and reaches highest concentrations in the blood plasma after one to four hours. When in the bloodstream, over 90% of the substance are bound to plasma proteins. It probably crosses the placenta, and is found in the breast milk in small amounts.It is metabolized by the liver enzyme CYP2C9 to the only weakly active 3-hydroxymethylmefenamic acid. 3-carboxymefenamic acid has also been identified as a metabolite, as well as carboxy glucuronides of all three substances. Mefenamic acid and its metabolites are excreted via the urine (52–67%) and the faeces (20–25%, or less than 20% following another source). The parent substance has a biological half-life of two hours; the half-life of its metabolites may be longer. History
Scientists led by Claude Winder from Parke-Davis invented mefenamic acid in 1961, along with fellow members of the class of anthranilic acid derivatives, flufenamic acid in 1963 and meclofenamate sodium in 1964.: 718   U.S. Patent 3,138,636 on the drug was issued in 1964.: 918–919 It was approved in the UK in 1963 as Ponstan, in West Germany in 1964 as Ponalar and in France as Ponstyl, and the US in 1967 as Ponstel.
Activity may refer to:

Action (philosophy), in general
Human activity: human behavior, in sociology behavior may refer to all basic human actions, economics may study human economic activities and along with cybernetics and psychology may study their modulation
Recreation, or activities of leisure
The Aristotelian concept of energeia, Latinized as actus
Activity (UML), a major task in Unified Modeling Language
Activity, the rate of catalytic activity, such as enzyme activity (enzyme assay), in physical chemistry and enzymology
Thermodynamic activity, the effective concentration of a solute for the purposes of  mass action
Activity (project management)
Activity, the number of radioactive decays per second
Activity (software engineering)
Activity (soil mechanics)
HMS Activity (D94), an aircraft carrier of the Royal Navy
"Activity", a song by Way Out West from Intensify
Cultural activities, activities referred to culture. See also
Activity theory, a learning theory in education
Social activity (disambiguation), several concepts in the social sciences
Activiti (software), an open source Business Process Management platform
Active (disambiguation)