Diagnosis
Treatment
Treatment is symptomatic, often addressing indicators associated with peripheral pulmonary artery stenosis. Laryngotracheal calcification resulting in dyspnea and forceful breathing can be treated with bronchodilators including the short and long-acting β2-agonists, and various anticholinergics. Prognosis
Prognosis is  good, yet life expectancy depends on the severity and extent of diffuse pulmonary and arterial calcification. History
Keutel Syndrom was first described by the pediatric Cardiologist Jürgen Keutel and Colleagues in 1972 in Göttingen, Germany. References
External links
Keutel syndrome at NIHs Office of Rare Diseases
Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). It is on the World Health Organizations List of Essential Medicines.Salts of this anion, especially  docusate sodium, are widely used in medicine as laxatives and as stool softeners, by mouth or rectally. In 2019, it was the 187th most commonly prescribed medication in the United States, with more than 3 million prescriptions. Some studies claim that docusate is not more effective than a placebo for improving constipation. Other docusate salts with medical use include those of calcium and potassium.Docusate salts are also used as food additives, emulsifiers, dispersants, and wetting agents, among other uses. History
Sodium docusate was patented in 1937 by Coleman R. Caryl and Alphons O. Jaeger for American Cyanamid, which commercialized it for many years as a detergent under the brand name Aerosol OT. Its use for the treatment of constipation was first proposed in 1955 by James L. Wilson and  David G. Dickinson, and quickly popularized under the name Doxinate. Medical use
Constipation
The main medical use of docusate sodium is to treat constipation, acting as a laxative and stool softener. In painful anorectal conditions such as hemorrhoid and anal fissures, it can help avoid pain caused by straining during bowel movements. When administered by mouth, a bowel movement often occurs in 1 to 3 days, while rectal use may be effective within 20 minutes.Sodium docusate is recommended as a stool softener for children.However, its effectiveness for constipation is poorly supported by evidence.