Ceftazidime/avibactam, sold under the brand name Avycaz among others, is a fixed-dose combination medication composed of ceftazidime, a cephalosporin antibiotic, and avibactam, a β-lactamase inhibitor. It is used to treat complicated intra-abdominal infections, urinary tract infections, and pneumonia. It is only recommended when other options are not appropriate. It is given by injection into a vein.Common side effect include nausea, fever, liver problems, headache, trouble sleeping, and pain at the site of injection. Severe side effects may include anaphylaxis, seizures, and Clostridioides difficile-associated diarrhea. While use appears to be safe in pregnancy the medication has not been well studied in this group. Doses should be adjusted in those with kidney problems. Ceftazidime works by interfering with the building of the bacterial cell wall while avibactam works by preventing ceftazidimes breakdown.The combination was approved for medical use in the United States and the European Union in 2015. It is on the World Health Organizations List of Essential Medicines. Resistances are increasingly been reported with United States, Greece and Italy accounting for 80% of cases. Medical use
Ceftazidime/avibactam is used to treat certain multidrug-resistant gram-negative infections.Ceftazidime/avibactam is used for the treatment of:

complicated intra-abdominal infections. In these cases it is often used in combination with metronidazole, which provides coverage for anaerobic pathogens. complicated urinary tract infections, including acute pyelonephritis, in adults. hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Bacterial activity
For many bacterial infections, it offers little or no advantage over ceftazidime monotherapy, due to the widespread expression of resistance mechanisms other than β-lactamase production.
Though brittle fracture is less common than other types of failure, the impacts to life and property can be more severe. The following notable historic failures were attributed to brittle fracture:

Pressure vessels: Great Molasses Flood in 1919, New Jersey molasses tank failure in 1973
Bridges: King Street Bridge span collapse in 1962, Silver Bridge collapse in 1967, partial failure of the Hoan Bridge in 2000
Ships: Titanic in 1912, Liberty ships during World War II, SS Schenectady in 1943

See also
Notes
References
Further reading
Dieter, G. E. (1988) Mechanical Metallurgy ISBN 0-07-100406-8
A. Garcimartin, A. Guarino, L. Bellon and S. Cilberto (1997) " Statistical Properties of Fracture Precursors ". Physical Review Letters, 79, 3202 (1997)
Callister, Jr., William D. (2002) Materials Science and Engineering: An Introduction. ISBN 0-471-13576-3
Peter Rhys Lewis, Colin Gagg, Ken Reynolds, CRC Press (2004), Forensic Materials Engineering: Case Studies. External links
Virtual museum of failed products at http://materials.open.ac.uk/mem/index.html
Fracture and Reconstruction of a Clay Bowl
Ductile fracture