Malignancies associated with these effects include gastric, colorectal, lung, bladder, and thyroid cancers, as well as squamous cell cancers of the cervix, vagina, penis, skin, and nasopharyrnx. Some hematological malignancies are likewise associated with secondary rises in blood eosinophil counts; these include Hodgkin disease, certain T-cell lymphomas, acute myeloid leukemia, the myelodysplastic syndromes, many cases of systemic mastocytosis, chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, myelofibrosis, chronic myelomonocytic leukemia, and certain cases of T-lymphoblastic leukemia/lymphoma-associated or myelodysplastic–myeloproliferative syndrome-associated eosinophilias.Hodgkin lymphoma (Hodgkins disease) often elicits severe eosinophilia; however, non-Hodgkin lymphoma and leukemia produce less marked eosinophilia. Of solid tumor neoplasms, ovarian cancer is most likely to provoke eosinophilia, though any other cancer can cause the condition. Solid epithelial cell tumors have been shown to cause both tissue and blood eosinophilia, with some reports indicating that this may be mediated by interleukin production by tumor cells, especially IL-5 or IL-3. This has also been shown to occur in Hodgkin lymphoma, in the form of IL-5 secreted by Reed-Sternberg cells. In primary cutaneous T cell lymphoma, blood and dermal eosinophilia are often seen. Lymphoma cells have also been shown to produce IL-5 in these disorders. Other types of lymphoid malignancies have been associated with eosinophilia, as in lymphoblastic leukemia with a translocation between chromosomes 5 and 14 or alterations in the genes which encode platelet-derived growth factor receptors alpha or beta. Patients displaying eosinophilia overexpress a gene encoding an eosinophil hematopoietin.
A brief trial of corticosteroids can be diagnostic for allergic causes, as the eosinophilia should resolve with suppression of the immune over-response. Neoplastic disorders are diagnosed through the usual methods, such as bone marrow aspiration and biopsy for the leukemias, MRI/CT to look for solid tumors, and tests for serum LDH and other tumor markers. Treatment
Treatment is directed toward the underlying cause. However, in primary eosinophilia, or if the eosinophil count must be lowered, corticosteroids such as prednisone may be used. However, immune suppression, the mechanism of action of corticosteroids, can be fatal in patients with parasitosis. List of causes
Eosinophilia can be idiopathic (primary) or, more commonly, secondary to another disease. In the Western World, allergic or atopic diseases are the most common causes, especially those of the respiratory or integumentary systems. In the developing world, parasites are the most common cause. A parasitic infection of nearly any bodily tissue can cause eosinophilia. Diseases that feature eosinophilia as a sign include:

Allergic disorders
Asthma
Hay fever
Drug allergies
Allergic skin diseasesPemphigus
Dermatitis herpetiformis
IgG4-related disease
Parasitic infections
Addisons disease and stress-induced suppression of adrenal gland function
Some forms of malignancy
Acute lymphoblastic leukemia
Chronic myelogenous leukemia
Eosinophilic leukemia
Clonal eosinophilia
Hodgkin lymphoma
Some forms of non-Hodgkin lymphoma
Lymphocyte-variant hypereosinophilia
Systemic mastocytosis
Systemic autoimmune diseasesSystemic lupus erythematosus
Kimura disease
Eosinophilic granulomatosis with polyangiitis
Eosinophilic fasciitis
Eosinophilic myositis
Eosinophilic myocarditis
Eosinophilic esophagitis
Eosinophilic gastroenteritis
Cholesterol embolism (transiently)
Coccidioidomycosis (Valley fever), a fungal disease prominent in the US Southwest. Human immunodeficiency virus infection
Interstitial nephropathy
Hyperimmunoglobulin E syndrome, an immune disorder characterized by high levels of serum IgE
Idiopathic hypereosinophilic syndrome.