Most meningococci from groups B and C, as well as gonococci, have been shown to have this trisaccharide as part of their LOS structure. The presence of these human cell surface mimics may, in addition to acting as a camouflage from the immune system, play a role in the abolishment of immune tolerance when infecting hosts with certain human leukocyte antigen (HLA) genotypes, such as HLA-B35.LPS can be sensed directly by hematopoietic stem cells (HSCs) through the bonding with TLR4, causing them to proliferate in reaction to a systemic infection. This response activate the TLR4-TRIF-ROS-p38 signaling within the HSCs and through a sustained TLR4 activation can cause a proliferative stress, leading to impair their competitive repopulating ability. Infection in mice using S. typhimurium showed similar results, validating the experimental model also in vivo. Effect of variability on immune response
O-antigens (the outer carbohydrates) are the most variable portion of the LPS molecule, imparting the antigenic specificity. In contrast, lipid A is the most conserved part. However, lipid A composition also may vary (e.g., in number and nature of acyl chains even within or between genera). Some of these variations may impart antagonistic properties to these LPS.
Sarna may refer to:

Sarna (Polish surname)
Sarna (Punjabi surname)
Sarna (clan), a Punjabi clan of India
Sarna, Warmian-Masurian Voivodeship, a village in northern Poland
Särna, a locality in Dalarna County, Sweden
SaRNA, small activating RNA
Sarna sthal – place of worship
Sarna (drug), a drug
Sarna (religion)

See also
All pages with titles containing Sarna
Sarnaism, the religious beliefs held by tribes in the state of Jharkhand, India, and other central Indian states
Srna (disambiguation)Sarna.net ("Sarna" for short) is the fan wiki project for the fictional BattleTech universe, named after the equally fictional star system therein.