Of these one, Benjamin Bell (1749-1806) was to achieve international fame largely through the success of his best selling textbook A System of Surgery first published in 1783. Hill’s early writing
Hill a number of articles for the medical journal Medical Essays and Observations which had been launched in 1733 by the Society for the Improvement of Medical Knowledge, which would eventually become the Royal Society of Edinburgh. This was one of the earliest regular medical journals and it provided a vehicle for case reports and other types of article. Hills articles give an insight into the range of conditions with which he dealt as a surgeon-apothecary, and his understanding of their causes and treatment. He contributed a case report about a patient who was temporarily ‘cured’ of syphilis by a ‘mercurial suffumigation’. After various therapies including laudanum, tonics, claret and Dr Plummers pills were unsuccessful, he resorted to mercury,  a recognised treatment for syphilis and fumes were thought to be the fastest mode of delivery. The symptoms eventually and she survived for more than a year. This report demonstrates that surgeons in Scotland at this time truly acted as surgeon-apothecaries. His report on two cases of hydatid disease describes one patient discharging hydatid cysts via a chronic cutaneous fistula from the liver and the other discharging cysts in the sputum. Both recovered without active treatment.
Ethylmalonic encephalopathy (EE) is a rare autosomal recessive inborn error of metabolism. Patients affected with EE are typically identified shortly after birth, with symptoms including diarrhea, petechiae and seizures. The genetic defect in EE is thought to involve an impairment in the degradation of sulfide intermediates in the body. Hydrogen sulfide then builds up to toxic levels. EE was initially described in 1994. Most cases of EE have been described in individuals of Mediterranean or Arabic origin. Signs and symptoms
Neurologic signs and symptoms include progressively delayed development, weak muscle tone (hypotonia), seizures, and abnormal movements. The bodys network of blood vessels is also affected. Children with this disorder may experience rashes of tiny red spots (petechiae) caused by bleeding under the skin and blue discoloration in the hands and feet due to reduced oxygen in the blood (acrocyanosis). Chronic diarrhea is another common feature of ethylmalonic encephalopathy. EE is often identified by urine organic acid analysis, the excretion of ethylmalonic acid, methylsuccinic acid, isobutyrylglycine and isovalerylglucine. Patients will also often have elevated thiosulphate concentration in their urine.The signs and symptoms of ethylmalonic encephalopathy are apparent at birth or begin in the first few months of life. Problems with the nervous system typically worsen over time, and most affected individuals survive only into early childhood. A few children with a milder, chronic form of this disorder have been reported, and there can be considerable phenotypic variation, even within families. The life expectancy of individuals with EE is less than ten years.