Protoscience
In European alchemy, the three primes (Latin: tria prima) were salt (), sulfur () and mercury (). The three doshas (weaknesses) and their antidotes are the basis of Ayurvedic medicine in India. Pseudoscience
Three is the symbolic representation for Mu, Augustus Le Plongeons and James Churchwards lost continent. In Pythagorean numerology the number 3 is the digit that represents the communication. It encourages the expansion of creativity, sociability between people and movement. For Pythagoras, the number 3 was a perfect number, representing harmony, perfection, and divine proportion. Philosophy
Philosophers such as Aquinas, Kant, Hegel, C. S. Peirce, and Karl Popper have made threefold divisions, or trichotomies, which have been important in their work. Hegels dialectic of Thesis + Antithesis = Synthesis creates three-ness from two-ness. Religion
Many world religions contain triple deities or concepts of trinity, including:

The Hindu Trimurti
The Hindu Tridevi
The Three Jewels of Buddhism
The Three Pure Ones of Taoism
The Christian Holy Trinity
The Triple Goddess of Wicca

Christianity
The threefold office of Christ is a Christian doctrine which states that Christ performs the functions of prophet, priest, and king. The ministry of Jesus lasted approximately three years. During the Agony in the Garden, Christ asked three times for the cup to be taken from him. Jesus rose from the dead on the third day after his death. The devil tempted Jesus three times. Saint Peter thrice denied Jesus and thrice affirmed his faith in Jesus. The Magi – wise men who were astronomers/astrologers from Persia – gave Jesus three gifts. There are three Synoptic Gospels and three epistles of John.
However, 40% went on to experience a new episode of mania or depression within 2 years of syndromal recovery, and 19% switched phases without recovery.Symptoms preceding a relapse (prodromal), especially those related to mania, can be reliably identified by people with bipolar disorder. There have been intents to teach patients coping strategies when noticing such symptoms with encouraging results. Suicide
Bipolar disorder can cause suicidal ideation that leads to suicide attempts. Individuals whose bipolar disorder begins with a depressive or mixed affective episode seem to have a poorer prognosis and an increased risk of suicide. One out of two people with bipolar disorder attempt suicide at least once during their lifetime and many attempts are successfully completed. The annual average suicide rate is 0.4%, which is 10–20 times that of the general population. The number of deaths from suicide in bipolar disorder is between 18 and 25 times higher than would be expected in similarly aged people without bipolar disorder. The lifetime risk of suicide has been estimated to be as high as 20% in those with bipolar disorder.Risk factors for suicide attempts and death from suicide in people with bipolar disorder include older age, prior suicide attempts, a depressive or mixed index episode (first episode), a manic index episode with psychotic symptoms, hopelessness or psychomotor agitation present during the episodes, co-existing anxiety disorder, a first degree relative with a mood disorder or suicide, interpersonal conflicts, occupational problems, bereavement or social isolation.