Achondrogenesis is a number of disorders that are the most severe form of congenital chondrodysplasia (malformation of bones and cartilage). These conditions are characterized by a small body, short limbs, and other skeletal abnormalities. As a result of their serious health problems, infants with achondrogenesis are usually born prematurely, are stillborn, or die shortly after birth from respiratory failure. Some infants, however, have lived for a while with intensive medical support. Researchers have described at least three forms of achondrogenesis, designated as Achondrogenesis type 1A, achondrogenesis type 1B and achondrogenesis type 2. These types are distinguished by their signs and symptoms, inheritance pattern, and genetic cause. Other types of achondrogenesis may exist, but they have not been characterized or their cause is unknown. Achondrogenesis type 1A is caused by a defect in the microtubules of the Golgi apparatus. In mice, a nonsense mutation in the thyroid hormone receptor interactor 11 gene (Trip11), which encodes the Golgi microtubule-associated protein 210 (GMAP-210), resulted in defects similar to the human disease. When their DNA was sequenced, human patients with achondrogenesis type 1A also had loss-of-function mutations in GMAP-210. GMAP-210 moves proteins from the endoplasmic reticulum to the Golgi apparatus. Because of the defect, GMAP-210 is not able to move the proteins, and they remain in the endoplasmic reticulum, which swells up. The loss of Golgi apparatus function affects some cells, such as those responsible for forming bone and cartilage, more than others.Achondrogenesis type 1B is caused by a similar mutation in SLC26A2, which encodes a sulfate transporter.
Ophiasis is a form of alopecia areata characterized by the loss of hair in the shape of a wave at the circumference of the head.It gets its name from Greek ὄφις ophis snake because of the apparent similarity to a snake-shape and the pattern of hair loss.The term "sisaipho" is used to characterize the inverse pattern. Sisaipho is, almost, the reverse spelling of ophiasis. It is also called "ophiasis inversus".This form of hair loss "...targets the bodys own hair follicles, resulting in hair loss..." and although the immune system could be attacking hair follicle melanocytes, dermal papilla cells, and keratinocytes,” the foundational cause of this disease is yet to be confirmed. Pattern of hair loss
This is one among many types of patterns of hair loss, “in which they have band-link hair loss across the occiput.” Hair loss can take the form of patches of hair being removed and there can also be spontaneous regrowth as well. Duration of hair loss
Ophiasis hair loss is one form in which the hair loss can further deteriorate and can extend “for more than a year.”

References
External links

Cheng Tan, MD; Wen-Wuan Zhu, MD. "Mosaic Hair Regrowth Pattern of Ophiasis and Androgenic Alopecia in a Patient With Alopecia Areata Totalis". Medscape. {{cite web}}:  CS1 maint: uses authors parameter (link)