See also
Germinal center B-cell like diffuse large B-cell lymphoma

References
Sources
Swerdlow SH, Campo E, Jaffe ES, Pileri SA, eds. (2008). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC. ISBN 978-92-832-2431-0. Goldman L, Schafer AI (2012). Goldmans Cecil Medicine (24th ed.). ISBN 978-1-4377-1604-7. Turgeon ML (2005). Clinical hematology: theory and procedures. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-5007-3. == External links ==
The first occurrence of a clinical event characteristic of MS in nearly half of the children examined was 2 years, though in a majority of cases, radiologic evolution, i.e. the increase in the number of size of lesions as detected in subsequent MRI, developed after one year. The presence of oligoclonal bands in the CSF and spinal cord lesions were associated with an increased risk of a first clinical event characteristic of MS. It was found that children with RIS had a substantial risk of subsequent clinical symptoms and/or radiologic evolution. Research directions
Calls have been made for longer prospective studies, tracking the development of potential disease progression over a longer period of time are warranted. This would ensure criteria in RIS is satisfactory and whether consideration should be given to treating individuals with RIS on current MS medication.RIS has been linked to prodromal multiple sclerosis. Etymology
The acronym RIS was coined in 2009 by Okuda and colleagues. Siva and colleagues suggested an alternate name, radiologically uncovered asymptomatic possible inflammatory-demyelinating disease (RAPIDD). == References ==