This clinical situation is known as Nelsons syndrome. Epidemiology
Cushings syndrome caused by treatment with corticosteroids is the most common form. Cushings disease is rare; a Danish study found an incidence of less than one case per million people per year. However, asymptomatic microadenomas (less than 10 mm in size) of the pituitary are found in about one in six individuals.People with Cushings syndrome have increased morbidity and mortality as compared to the general population. The most common cause of mortality in Cushings syndrome is cardiovascular events. People with Cushings syndrome have nearly 4 times increased cardiovascular mortality as compared to the general population.About 0.9 to 1% of those with Cushings syndrome has tendency to develop venous thrombosis. Other factors such as surgery and obesity also increases the chance of getting thrombosis. Other animals
For more information on the form in horses, see pituitary pars intermedia dysfunction. See also
Addisons disease
Adrenal insufficiency (hypocortisolism)
Corticosteroid-induced lipodystrophy

References
External links
"Cushings Syndrome". MedlinePlus. U.S. National Library of Medicine.
When children get older, they often realize and report to their parents that they do not actually possess a sense of smell, often to the surprise of their parents. Causes
A temporary loss of smell can be caused by a blocked nose or infection. In contrast, a permanent loss of smell may be caused by death of olfactory receptor neurons in the nose or by brain injury in which there is damage to the olfactory nerve or damage to brain areas that process smell (see olfactory system). The lack of the sense of smell at birth, usually due to genetic factors, is referred to as congenital anosmia. Family members of the patient with congenital anosmia are often found with similar histories; this suggests that the anosmia may follow an autosomal dominant pattern. Anosmia may very occasionally be an early sign of a degenerative brain disease such as Parkinsons disease and Alzheimers disease.Another specific cause of permanent loss could be from damage to olfactory receptor neurons because of use of certain types of nasal spray; i.e., those that cause vasoconstriction of the nasal microcirculation. To avoid such damage and the subsequent risk of loss of smell, vasoconstricting nasal sprays should be used only when absolutely necessary and then for only a short amount of time. Non-vasoconstricting sprays, such as those used to treat allergy-related congestion, are safe to use for prescribed periods of time. Anosmia can also be caused by nasal polyps. These polyps are found in people with allergies, histories of sinusitis, and family history.