A thyroid adenoma is a benign tumor of the thyroid gland, that may be inactive or active (functioning autonomously) as a toxic adenoma. Signs and symptoms
A thyroid adenoma may be clinically silent ("cold" adenoma), or it may be a functional tumor, producing excessive thyroid hormone ("warm" or "hot" adenoma). In this case, it may result in symptomatic hyperthyroidism, and may be referred to as a toxic thyroid adenoma. Diagnosis
Morphology
Thyroid follicular adenoma ranges in diameter from  3 cm on an average, but sometimes is larger (up to 10 cm) or smaller. The typical thyroid adenoma is solitary, spherical and encapsulated lesion that is well demarcated from the surrounding parenchyma. The color ranges from gray-white to red-brown, depending upon

the cellularity of the adenoma
the colloid content.Areas of hemorrhage, fibrosis, calcification, and cystic change, similar to what is found in multinodular goiters, are common in thyroid (follicular) adenoma, particularly in larger lesions. Types
Almost all thyroid adenomata are follicular adenomata. Follicular adenomata can be described as "cold", "warm" or "hot" depending on their level of function. Histopathologically, follicular adenomata can be classified according to their cellular architecture and relative amounts of cellularity and colloid into the following types:

Fetal (microfollicular) - these have the potential for microinvasion. These consist of small, closely packed follicles lined with epithelium. Colloid (macrofollicular) - these do not have any potential for microinvasion
Embryonal (atypical) - have the potential for microinvasion. Hürthle cell adenoma (oxyphil or oncocytic tumor) - have the potential for microinvasion. Hyalinizing trabecular adenomaPapillary adenomata are very rare.
A randomised control trial of misoprostol use found a 38% reduction in maternal deaths due to post partum haemorrhage in resource-poor communities. Misoprostol is recommended due to its cost, effectiveness, stability, and low rate of side effects. Oxytocin must also be given by injection, while misprostol can be given orally or rectally for this use, making it much more useful in areas where nurses and physicians are less available. Insertion of intrauterine contraceptive device
In women with prior caesarean section or prior failure of insertion of an intrauterine contraceptive device, pre-procedure administration of misoprostol reduces the rate of failure of insertion of intrauterine contraceptive device. However, due to a higher rate of adverse effects, routine use of misoprostol for this purpose in other women is not supported by the data. Other
For cervical ripening in advance of endometrial biopsy to reduce the need for use of a tenaculum or cervical dilator.There is limited evidence supporting the use of misoprostol for the treatment of trigeminal neuralgia in patients with multiple sclerosis. Adverse effects
The most commonly reported adverse effect of taking misoprostol by mouth for the prevention of stomach ulcers is diarrhea.