To date, 200 people with hEDS have had whole genome sequencing, and 500 have had whole exome sequencing; this study aims to increase those numbers significantly.Promising outcomes of this increased screening have been reported by the Norris Lab, led by Russell Norris, in the Department of Regenerative Medicine and Cell Biology at Medical University of South Carolina. Using CRISPR Cas-9 mediated genome editing on mouse models of the disease, the lab has recently identified a "very strong candidate gene" for hEDS. This finding, and a greater understanding of cardiac complications associated with the majority of EDS subtypes, has led to the development of multiple druggable pathways involved in aortic and mitral valve diseases. While this candidate gene has not been publicly identified, the Norris lab has conducted several studies involving small population genome sequencing and come up with a working list of possible hEDS genes. A mutation in COL3A1 in a single family with autosomal dominant hEDS phenotype was found to cause reduced collagen secretion and an over-modification of collagen. In 35 families, copy number alterations in TPSAB1, encoding alpha-tryptase, were associated with increased basal serum tryptase levels, associated with autonomic dysfunction, gastrointestinal disorders, allergic and cutaneous symptoms, and connective tissue abnormalities, all concurrent with hEDS phenotype. Lastly, Tenascin X, an extracellular matrix protein important for collagen mutation encoded by the TNXB gene, has been associated with hEDS in patients with Tenascin X deficiency.
She uses a wheelchair and was the first full-time disabled actress on Coronation Street
Drag queen and winner of the 11th season of RuPauls Drag Race Yvie Oddly
Eric the Actor, a regular caller to The Howard Stern Show
Actress and activist Jameela Jamil
Writer and actress Lena Dunham
Australian singer Sia
Singer Halsey
YouTuber and disability rights activist Annie Elainey
Miss America 2020 Camille Schrier
Deaf singer/songwriter Mandy Harvey
Pornographic actress and writer Lorelei Lee
Reality show contestant Trevor Jones, dead from the vascular form of the disorder
Scrunchie creator Rommy Hunt Revson, dead from a ruptured aorta

Other species
Ehlers–Danlos-like syndromes have been shown to be hereditary in Himalayan cats, some domestic shorthair cats, and certain breeds of cattle. It is seen as a sporadic condition in domestic dogs. It has a similar treatment and prognosis. Animals with the condition should not be bred, as the condition can be inherited. Animal EDS
		
		
		
Degenerative suspensory ligament desmitis is a similar condition seen in many breeds of horses. It was originally notated in the Peruvian Paso and thought to be a condition of overwork and older age, but it is being recognized in all age groups and all activity levels. It has been noted in newborn foals. See also
Hypermobility spectrum disorder

References
External links

Ehlers–Danlos syndromes at Curlie