This subtype is characterized by a trajectory in which some developmental skills are gained, then they stabilize and delays occur, and these are followed by regression. Early symptoms include difficulty crawling and walking, hypotonia, speech and swallowing problems, and seizures. Neurological symptoms include ataxia, seizures, dementia, and difficulties with speech. Adult GM1
Onset of adult GM1 is typically in adolescence or adulthood and is the slowest progressing of the subtypes. Symptoms include muscle atrophy, neurological complications that are less severe and progress at a slower rate than in other forms of the disorder, corneal clouding in some patients, and dystonia (sustained muscle contractions that cause twisting and repetitive movements or abnormal postures). Angiokeratomas may develop on the lower part of the trunk of the body. Most patients have a normal size liver and spleen. Prenatal diagnosis is possible by measurement of Acid Beta Galactosidase in cultured amniotic cells. Treatment
There is no cure for GM1, although several gene therapy trials are underway. More information for these can be found at ClinicalTrials.gov. Treatment for GM1 is symptom-based and palliative. References
External links
CureGM1 Foundations mission is to fund research for the benefit of all those who suffer from GM1 gangliosidosis. National Tay-Sachs & Allied Diseases Association (NTSAD) provides support for families Tay-Sachs, Canavan, GM1, and Sandhoff diseases by driving research, forging collaboration, and fostering community. MPS Society is based in the UK and provides support and resources for families with MPS (Mucopolysaccharide), Fabry and related disorders, including GM1.
Another procedure is posterior colporrhaphy, which involves suturing of vaginal tissue. Surgery may also involve insertion of a supporting mesh (that is, a patch). There are also surgical techniques directed at repairing or strengthening the rectovaginal septum, rather than simple excision or plication of vaginal skin which provides no support. Both gynecologists and colorectal surgeons can address this problem. Potential complications of surgical correction of a rectocele include bleeding, infection, dyspareunia (pain during intercourse), as well as recurrence or even worsening of the rectocele symptoms. The use of synthetic or biologic grafts has been questioned. References
External links

Rectocele details, description, video (in Russia)