In humans, early clinical trials (phase I) have been conducted in non-Hodgkin lymphoma, blast crisis, and a wide range of advanced or refractory solid tumors, including colon cancer, head and neck cancer, melanoma, ovarian cancer, and prostate cancer. Compassionate use in patients with acute myeloid leukemia has also been reported.The pivotal clinical trial which served to support approval of selinexor for people with relapsed/refractory multiple myeloma was an open-label study of 122 patients known as the STORM trial. In all of the enrolled patients, patients had been treated with a median of seven prior treatment regimens including conventional chemotherapy, targeted therapy with bortezomib, carfilzomib, lenalidomide, pomalidomide, and a monoclonal antibody (daratumumab or isatuximab); nearly all had also undergone hematopoietic stem cell transplantation but had disease that continued to progress. The overall response rate was 26%, including two stringent complete responses; 39% of patients had a minimal response or better. The median duration of response was 4.4 months, median progression-free survival was 3.7 months, and median overall survival was 8.6 months.As of 2019, phase I/II and III trials are ongoing, including the use of selinexor in other cancers and in combinations with other drugs used for multiple myeloma.In November 2020, results from the multi-center, Phase III, randomized study (NCT03110562) which evaluated 402 participants with relapsed or refractory multiple myeloma who had received one to three prior lines of therapy were published in The Lancet.
Cambia can mean:

Cambia, Haute-Corse, a commune in the Haute-Corse department of France
Cambia (non-profit organization), an open science and biology non-profit institute based in Australia
Cambia Health Solutions, an American health insurance company
Cambia or cambiums, the four humours in medicine
Cambia, a trade name for the anti-inflammatory drug diclofenac
the plural of cambium (botany), a type of tissue found in plants

See also
Cambio (disambiguation)
Cambria (disambiguation)
Kambia (disambiguation)
Cumbia, a style of music and dance
Cumbria, a county of England