For example, arthritic symptoms might make it difficult for a person to move around and/or exercise, which can lead to secondary effects, such as:

Muscle weakness
Loss of flexibility
Decreased aerobic fitnessThese changes, in addition to the primary symptoms, can have a huge impact on quality of life. Disability
Arthritis is the most common cause of disability in the United States. More than 20 million individuals with arthritis have severe limitations in function on a daily basis. Absenteeism and frequent visits to the physician are common in individuals who have arthritis. Arthritis can make it difficult for individuals to be physically active and some become home bound. It is estimated that the total cost of arthritis cases is close to $100 billion of which almost 50% is from lost earnings. Each year, arthritis results in nearly 1 million hospitalizations and close to 45 million outpatient visits to health care centers.Decreased mobility, in combination with the above symptoms, can make it difficult for an individual to remain physically active, contributing to an increased risk of obesity, high cholesterol or vulnerability to heart disease. People with arthritis are also at increased risk of depression, which may be a response to numerous factors, including fear of worsening symptoms. Risk factors
There are common risk factors that increase a persons chance of developing arthritis later in adulthood. Some of these are modifiable while others are not. Smoking has been linked to an increased susceptibility of developing arthritis, particularly rheumatoid arthritis.
The term was first used by Foreign Ministry spokesman Gennadi Gerasimov in 1987, who was quoted as saying "We now have the Frank Sinatra doctrine. He has a song, I Did It My Way. So every country decides on its own which road to take". References
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