Genetic Counselling
Diagnosis of ADNFLE, however, is not only based on neuroimaging, and ictal and interictal EEGs, but also on family history and genetic counseling. Certain molecular and genomics testing that can include multi-gene panel of CHRNA4, CHRNB2, CHRNA2, KCNT1, DEPDC5, CRH, serial single gene testing of pathogenic variants, and can also be comprehensive genomic testing. There has to be continuous neuroimaging and EEGs, for reevaluation at regular intervals, to keep a check on disease progression. Video EEG
As the FLE occurred during sleep video EEG is one of the useful tools for diagnosis of FLE. The monitoring can be done in the sleep lab in the hospital overnight. Both brain activity, as well as behavioral movement, can be captured by using video EEG. PET Scan
Positron emission tomography (PET) helps to locate epileptogenic loci. If the MRI were normal the PET scan could locate some abnormalities. Common misdiagnoses
Episodes that include complex hyperactivity of the proximal portions of the limbs that lead to increased overall motor activity are called hypermotor seizures. When associated with bizarre movements and vocalizations these seizures are often misdiagnosed as psychogenic or functional sezures or other episodic movement disorders such as psychogenic movement disorders, familial paroxysmal dystonic choreoathetosis, paroxysmal kinesogenic choreoathetosis, or episodic ataxia type 1. Hypermotor seizure in children are often confused with pavor nocturnus (night terrors).
A classic example is Phineas Gage, who exhibited a change in behavior after one or both frontal lobes were destroyed by a large iron bar accidentally driven through his head (though Gage, despite conventional presentations of his case, did not exhibit the aggression, antisocial behavior, or loss of impulse control sometimes reported in patients with similar injuries). There are two main regions of the prefrontal cortex that each control various aspects of behavior and personality:

Dorsolateral prefrontal cortex
This area is associated with the impairment of the cognitive abilities that control and regulate behavior and long-term memory formation (especially relating to procedural sequence memory) when either brain damage or a lesion is present. Orbitofrontal cortex
The orbitofrontal cortex has similar functions as the dorsolateral prefrontal cortex but is thought to be mainly responsible for the ability to make choices and determine right from wrong. Social effects and quality of life
Epilepsy has a substantial impact on the quality of life of the individuals that are affected by it, yet there is lack of proper examination of social cognitive functions. Physicians and researchers are coming to understand that the impact on the quality of life of the patient is as important as the effects of the seizures. Quality of life questionnaires and other assessment tools have been created to help quantify quality of life for individual patients. They consider such factors as physical health (including numbers and severity of seizures, medication side effects etc. ), mental health, social relationships, lifestyle, role activities and life fulfillment.