genetic alleles), genetical-based T cell receptors, or variations in their efficiency to absorb, distribute to tissues, metabolize, or excrete (this combination is termed ADME) a drug are predisposed to develop SJS. Medications
Although SJS can be caused by viral infections and malignancies, the main cause is medications. A leading cause appears to be the use of antibiotics, particularly sulfa drugs. Between 100 and 200 different drugs may be associated with SJS. No reliable test exists to establish a link between a particular drug and SJS for an individual case. Determining what drug is the cause is based on the time interval between first use of the drug and the beginning of the skin reaction. Drugs discontinued more than 1 month prior to onset of mucocutaneous physical findings are highly unlikely to cause SJS and TEN. SJS and TEN most often begin between 4 and 28 days after culprit drug administration. A published algorithm (ALDEN) to assess drug causality gives structured assistance in identifying the responsible medication.SJS may be caused by the medications rivaroxaban, vancomycin, allopurinol, valproate, levofloxacin, diclofenac, etravirine, isotretinoin, fluconazole, valdecoxib, sitagliptin, oseltamivir, penicillins, barbiturates, sulfonamides, phenytoin, azithromycin, oxcarbazepine, zonisamide, modafinil, lamotrigine, nevirapine, pyrimethamine, ibuprofen, ethosuximide, carbamazepine, bupropion, telaprevir, and nystatin.Medications that have traditionally been known to lead to SJS, erythema multiforme, and toxic epidermal necrolysis include sulfonamide antibiotics, penicillin antibiotics, cefixime (antibiotic), barbiturates (sedatives), lamotrigine, phenytoin (e.g., Dilantin) (anticonvulsants) and trimethoprim.
Treatment
Non-surgical treatment of radial tunnel syndrome includes rest, NSAID, therapy with modalities, work modification, ergonomic modification, injection if associated with lateral epicondylitis.Patients whose conditions are more adapted to surgical intervention are those who do not respond to prolonged conservative treatment. The patient must have pain with resisted supination, positive middle finger test, positive electrodiagnostic findings, and pain relief after anesthetic injection into the radial tunnel. Based on 2002 data, surgical decompression leads to 60–70% good or excellent results. See also
Golfers elbow
Repetitive strain injury
Tennis elbow

References
Further reading
Books
Rind, Libi; Pobre, Thomas; Weiss, Frederick; Magyar, Yasha; Ruotolo, Charles; Aldad, Tamir; Mahboubian, Shahab; Knijnikov, Alexander; Asheld, Wilbur J. (2010). "Radial tunnel syndrome and supinator syndrome". In Weiss, Lyn D.; Weiss, Jay M.; Pobre, Thomas (eds.). Oxford American Handbook of Physical Medicine & Rehabilitation. Oxford University Press. pp. 96–7. ISBN 978-0-19-536777-5. Wertsch, Jacqueline J.; Hoch, Anne Zeni (2009). "Radial Tunnel Syndrome". In Akuthota, Venu; Herring, Stanley A. (eds.). Nerve and Vascular Injuries in Sports Medicine. Berlin: Springer. pp. 79–80. ISBN 978-0-387-76599-0. Russell, Stephen M. (2006). "Radial Tunnel Syndrome". Examination of peripheral nerve injuries: an anatomical approach. Stuttgart: Thieme. p. 62. ISBN 978-3-13-143071-7. Saladin, Kenneth S. (2012). Anatomy & Physiology: The Unity of Form and Function. McGraw Hill. p. 496. ISBN 978-0-07-337825-1. Journals
Dickerman, Rob D.; Stevens, Qualls E. J.; Cohen, Anders J.; Jaikumar, S. (2002). "Radial tunnel syndrome in an elite power athlete: a case of direct compressive neuropathy". Journal of the Peripheral Nervous System. 7 (4): 229–32. doi:10.1046/j.1529-8027.2002.02030.x. PMID 12477169.