Stimulation is somewhat more common than with other related antihistamines, and is especially common in the elderly. Common side effects include dry mouth, dizziness, drowsiness, constipation, urine retention, blurred vision, and headache. Its use in Parkinsons is especially limited by these factors.People with glaucoma, digestive problems such as peptic ulcers or bowel obstruction, or sphincter relaxation disorders, or with enlarged prostate, bladder problems, or myasthenia gravis, should not take this drug. Pharmacology
Orphenadrine is known to have this pharmacology:

Nonselective mACh receptor antagonist (anticholinergic, 58% as potent as atropine)  Various monographs and package inserts, nursing manuals, journal articles and so forth have proposed the theory that this anticholinergic (atropine-like) activity, NMDA antagonism and possible local anaesthetic and miscellaneous analgesic effects may be the reason for orphenadrines efficacy against muscle and other pain. These reasons are behind the use of orphenadrine and other drugs of a number of types which are used with paracetamol, aspirin, naproxen, and similar agents with or without opioid analgesics to more effectively manage pain of various types. H1 receptor antagonist (antihistamine)
NMDA receptor antagonist (Ki value of 6.0 ± 0.7 μM, one hundred times less potent than phencyclidine, which binds with a Ki of 59 nM)
NDRI (norepinephrine and dopamine reuptake inhibitor)
Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker
HERG potassium channel blocker

History
George Rieveschl was a professor of chemistry at the University of Cincinnati and led a research program working on antihistamines. In 1943, one of his students, Fred Huber, synthesized diphenhydramine.
Uses
Placement of a catheter into a particular part of the body may allow:

Draining urine from the urinary bladder as in urinary catheterization, using intermittent catheters or Foley catheter inserted through urethra. When the urethra is damaged, suprapubic catheterisation is used instead. The suprapubic catheter is inserted through the lower part of the abdomen directly into the urinary bladder. drainage of urine from the kidney by percutaneous (through the skin) nephrostomy
drainage of fluid collections, e.g. an abdominal abscess
pigtail catheter: used to drain air from around the lung (pneumothorax)
administration of intravenous fluids, medication or parenteral nutrition with a peripheral venous catheter or central venous catheter
angioplasty, angiography, balloon septostomy, balloon sinuplasty, cardiac electrophysiology testing, catheter ablation. Often the Seldinger technique is used. direct measurement of blood pressure in an artery or vein
direct measurement of intracranial pressure
administration of anaesthetic medication into the epidural space, the subarachnoid space, or around a major nerve bundle such as the brachial plexus
transfer of fertilized embryos, from in vitro fertilization, or sperm, during artificial insemination, into the uterus
administration of oxygen, volatile anesthetic agents, and other breathing gases into the lungs using a tracheal tube
subcutaneous administration of insulin or other medications, with the use of an infusion set and insulin pump

History
Ancient inventors
Ancient Chinese used onion stalks, the Romans, Hindus, and Greeks used tubes of wood or precious metals.The ancient Syrians created catheters from reeds. Modern
The earliest invention of the flexible catheter was during the 18th century.