Varying degree of symmetric T2 hyperintense signal changes in the basal ganglia (i.e., caudate and putamen), and to a lesser extent globus pallidus and occipital cortex. Cerebellar atrophyBrain FDG PET-CT tends to be markedly abnormal, and is increasingly used in the investigation of dementias. Patients with CJD will normally have hypometabolism on FDG PET. Histopathology
Testing of tissue remains the most definitive way of confirming the diagnosis of CJD, although it must be recognized that even biopsy is not always conclusive.In one-third of people with sporadic CJD, deposits of "prion protein (scrapie)", PrPSc, can be found in the skeletal muscle and/or the spleen. Diagnosis of vCJD can be supported by biopsy of the tonsils, which harbor significant amounts of PrPSc; however, biopsy of brain tissue is the definitive diagnostic test for all other forms of prion disease. Due to its invasiveness, biopsy will not be done if clinical suspicion is sufficiently high or low. A negative biopsy does not rule out CJD, since it may predominate in a specific part of the brain.The classic histologic appearance is spongiform change in the gray matter: the presence of many round vacuoles from one to 50 micrometers in the neuropil, in all six cortical layers in the cerebral cortex or with diffuse involvement of the cerebellar molecular layer. These vacuoles appear glassy or eosinophilic and may coalesce. Neuronal loss and gliosis are also seen. Plaques of amyloid-like material can be seen in the neocortex in some cases of CJD.However, extra-neuronal vacuolization can also be seen in other disease states.
Sinus may refer to:

Anatomy
Sinus (anatomy), a sac or cavity in any organ or tissue
Paranasal sinuses, air cavities in the cranial bones, especially those near the nose, including:
Maxillary sinus, is the largest of the paranasal sinuses, under the eyes, in the maxillary bones
Frontal sinus, superior to the eyes, in the frontal bone, which forms the hard part of the forehead
Ethmoid sinus, formed from several discrete air cells within the ethmoid bone between the eyes and under the nose
Sphenoidal sinus, in the sphenoid bone at the center of the skull base under the pituitary gland
Anal sinuses, the furrows which separate the columns in the rectum
Dural venous sinuses, venous channels found between layers of dura mater in the brain
Sinus (botany), a space or indentation, usually on a leaf

Heart
Sinus node, a structure in the superior part of the right atrium
Sinus rhythm, normal beating on an ECG
Coronary sinus, a vein collecting blood from the heart
Sinus venosus, a cavity in the heart of embryos
Sinus venarum, a part of the wall of the right atrium in adults, developed from the sinus venosus

Other uses
Sinus (Chalcidice), a town of ancient Chalcidice, Greece
Sinus, gulf or bay in Latin, used in numerous toponyms in ancient writing (e.g., Sinus Magnus, Sinus Flanaticus, etc.) Sine, a trigonometric math function (Latin sinus)

See also
Sinus Medii, a small lunar mare
Sinus Successus, a lunar feature
Sines, a municipality in Alentejo, Portugal (Latin Sinus)
Sinusitis, a common ailment resulting in the inflammation of the paranasal sinuses