Cortisol is thus better thought of as stimulating glucose/glycogen turnover in the liver. This is in contrast to cortisols effect in the skeletal muscle where glycogenolysis is promoted indirectly through catecholamines. Metabolism of proteins and lipids
Elevated levels of cortisol, if prolonged, can lead to proteolysis (breakdown of proteins) and muscle wasting. The reason for proteolysis is to provide the relevant tissue with a feedstock for gluconeogenesis; see glucogenic amino acids. The effects of cortisol on lipid metabolism are more complicated since lipogenesis is observed in patients with chronic, raised circulating glucocorticoid (i.e. cortisol) levels, although an acute increase in circulating cortisol promotes lipolysis. The usual explanation to account for this apparent discrepancy is that the raised blood glucose concentration (through the action of cortisol) will stimulate insulin release. Insulin stimulates lipogenesis, so this is an indirect consequence of the raised cortisol concentration in the blood but it will only occur over a longer time scale. Immune response
Cortisol prevents the release of substances in the body that cause inflammation. It is used to treat conditions resulting from overactivity of the B-cell-mediated antibody response. Examples include inflammatory and rheumatoid diseases, as well as allergies. Low-dose topical hydrocortisone, available as a nonprescription medicine in some countries, is used to treat skin problems such as rashes and eczema. Cortisol inhibits production of interleukin 12 (IL-12), interferon gamma (IFN-gamma), IFN-alpha, and tumor necrosis factor alpha (TNF-alpha) by antigen-presenting cells (APCs) and T helper cells (Th1 cells), but upregulates interleukin 4, interleukin 10, and interleukin 13 by Th2 cells.
To be initiated under a guru, one must have had no caffeine, alcohol, nicotine or other drugs, for at least a year.Caffeinated beverages are widely consumed by Muslims today. In the 16th century, some Muslim authorities made unsuccessful attempts to ban them as forbidden "intoxicating beverages" under Islamic dietary laws. Other organisms
Recently discovered bacteria Pseudomonas putida CBB5 can live on pure caffeine and can cleave caffeine into carbon dioxide and ammonia.Caffeine is toxic to birds and to dogs and cats, and has a pronounced adverse effect on mollusks, various insects, and spiders. This is at least partly due to a poor ability to metabolize the compound, causing higher levels for a given dose per unit weight. Caffeine has also been found to enhance the reward memory of honey bees. Research
Caffeine has been used to double chromosomes in haploid wheat. See also
Theobromine
Theophylline
Methylliberine
Adderall
Amphetamine
Cocaine
Nootropic
Wakefulness-promoting agent

References
Notes
Citations

Bibliography
Bersten I (1999). Coffee, Sex & Health: A history of anti-coffee crusaders and sexual hysteria. Sydney: Helian Books. ISBN 978-0-9577581-0-0. Carpenter M (2015). Caffeinated: How Our Daily Habit Helps, Hurts, and Hooks Us. Plume. ISBN 978-0142181805. Pendergrast M (2001) [1999]. Uncommon Grounds: The History of Coffee and How It Transformed Our World. London: Texere. ISBN 978-1-58799-088-5. Pollan M (2021). This Is Your Mind on Plants. Penguin Press. ISBN 9780593296905. External links

GMD MS Spectrum
Caffeine: ChemSub Online
Caffeine at The Periodic Table of Videos (University of Nottingham)