One evaluation of the different stresses in peoples lives is the Holmes and Rahe stress scale. General adaptation syndrome
Physiologists define stress as how the body reacts to a stressor - a stimulus, real or imagined. Acute stressors affect an organism in the short term; chronic stressors over the longer term. The general adaptation syndrome (GAS), developed by Hans Selye, is a profile of how organisms respond to stress; GAS is characterized by three phases: a nonspecific mobilization phase, which promotes sympathetic nervous system activity; a resistance phase, during which the organism makes efforts to cope with the threat; and an exhaustion phase, which occurs if the organism fails to overcome the threat and depletes its physiological resources. Stage 1
Alarm is the first stage, which is divided into two phases: the shock phase and the antishock phase. Shock phase: During this phase, the body can endure changes such as hypovolemia, hypoosmolarity, hyponatremia, hypochloremia, hypoglycemia—the stressor effect. This phase resembles Addisons disease. The organisms resistance to the stressor drops temporarily below the normal range and some level of shock (e.g. circulatory shock) may be experienced. Antishock phase: When the threat or stressor is identified or realized, the body starts to respond and is in a state of alarm. During this stage, the locus coeruleus and sympathetic nervous system activate the production of catecholamines including adrenaline, engaging the popularly-known fight-or-flight response. Adrenaline temporarily provides increased muscular tonus, increased blood pressure due to peripheral vasoconstriction and tachycardia, and increased glucose in blood.
Monostotic fibrous dysplasia is a form of fibrous dysplasia where only one bone is involved. It comprises a majority of the cases of fibrous dysplasia (approximately 70–80%).It is a rare bone disease characterized by the replacement of normal elements of the bone by fibrous connective tissue, which can cause very painful swellings and bone deformities, and make bone abnormally fragile and prone to fracture.A congenital, noninherited, benign anomaly of bone development in a single bone, it consists of the replacement of normal marrow and cancellous bone by immature bone with fibrous stroma. Monostotic fibrous dysplasia occurs with equal frequency in both sexes and normally develops early in life, with lesions frequently identified late in the first and early second decades. Most patients are asymptomatic, with the diagnosis often established after an incidental finding or with pain, swelling, or fracture. Lesions usually enlarge in proportion to skeletal growth and the abnormal replacement remain active only until skeletal maturity.Monostotic fibrous dysplasia does not convert into the polyostotic type. When symptoms are present, they often are nonspecific, including pain, swelling, or pathologic fracture. It most often affects the ribs (28%), proximal femur (23%), tibia, craniofacial bones (10-25%) and humerus (10-25%). See also
Polyostotic fibrous dysplasia

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