Tarot: Witch of the Black Rose graphic novel debut the ghost twin, She/they are constant companion(s) of Skeleton Man, her protector. The Broadway musical Side Show depicts the lives of real-life conjoined twins Daisy and Violet Hilton, portrayed in the original Broadway production by Alice Ripley and Emily Skinner. Reiko the Zombie Shop, 1990s womens horror manga, bonus chapters focus on unexpectedly life of Noriko and her "sister". Summoners Dr. Zero can resurrect and control fuse zombies called medicinal death. MA GI & CA L., a conjoined magical alternative android, from psychology horror manga Magical Girl Apocalypse. In the TV series The Addams Family, there are extended family members of the Addams Family who are mentioned to have two heads. In "Mother Lurch Visits the Addams Family," Morticia Addams mentions that she has a Cousin Slimy who has two good heads on his shoulder. In "Progress and the Addams Family," Morticia was making a knitted hat for Cousin Plato where Gomez Addams has stated that his left head is size 6 and his right head is size 8 3/4. In "Lurchs Little Helper," Morticia made a portrait of Cousin Crimp who has a male head and a female head. Tamil actor Suriya portrays Vimalan and Akilan, conjoined twins in the 2012 film, Maattrraan. The book The Girls, by Canadian novelist Lori Lansens, published in 2005, is the fictional autobiography of Canadian craniopagus twins Rose and Ruby Darlen with Slovakian background. Irish author Sarah Crossan won the Carnegie Medal for her verse novel, One.
Verteporfin (trade name Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 689 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.Verteporfin is also used off-label for the treatment of central serous retinopathy. Administration
Verteporfin is usually injected intravenously into the largest arm vein. It is injected at a dose of 6 mg/m2 and light-activated. It is usually is given 15 minutes before laser treatment. This dose can be repeated 4 times per year. Contraindications
Porphyria. Side effects
Most common side effects are blurred vision, headache, and local effects at the injection site. Also, photosensitivity; it is strictly advised to avoid exposure to sunlight and unscreened lighting until 48 hours after verteporfin administration.Dogs and rats have been treated with inactivated daily doses 32–70 times higher than the dose advised for humans. The 4 weeks of treatment resulted in mild extravascular hemolysis and hematopoiesis in the animals. Interactions
Verteporfin is known to interact with the herbal remedy feverfew (Tanacetum parthenium), the latter of which seems to act as an antagonist to verteporfin for unknown reasons.