A total of 310 people, including 10 from Cuba, perished during this storm. The storm cost $6 to $10 billion in damages. List of blizzards
North America
1700 to 1799
The Great Snow 1717 series of four snowstorms between February 27 and March 7, 1717. There were reports of about five feet of snow already on the ground when the first of the storms hit. By the end, there were about ten feet of snow and some drifts reaching 25 feet (7.6 m), burying houses entirely. In the colonial era, this storm made travel impossible until the snow simply melted. Blizzard of 1765. March 24, 1765. Affected area from Philadelphia to Massachusetts. High winds and over 2 feet (61 cm) of snowfall recorded in some areas. Blizzard of 1772. "The Washington and Jefferson Snowstorm of 1772". January 26–29, 1772. One of largest D.C. and Virginia area snowstorms ever recorded. Snow accumulations of 3 feet (91 cm) recorded. The "Hessian Storm of 1778". December 26, 1778. Severe blizzard with high winds, heavy snows and bitter cold extending from Pennsylvania to New England. Snow drifts reported to be 15 feet (4.6 m) high in Rhode Island. Storm named for stranded Hessian troops in deep snows stationed in Rhode Island during the Revolutionary War. The Great Snow of 1786. December 4–10, 1786. Blizzard conditions and a succession of three harsh snowstorms produced snow depths of 2 feet (61 cm) to 4 feet (120 cm) from Pennsylvania to New England. Reportedly of similar magnitude of 1717 snowstorms. The Long Storm of 1798.
Experiments on transgenic mice are investigating the initial sites of viral replication in the host and how the virus moves from the bloodstream into the central nervous system. Research into the host range of the virus has also been of interest. The host range of a virus is determined by the interaction of the virus with host cellular receptors such as CD155. Comparison of the amino acid sequence in the binding domain of the host cell receptor is highly variable among mammalian species. Rapid changes in the sequence of the binding domain have restricted the host range of the poliovirus. Targeting of the brain and spinal cord have also come under investigation. The restricted tropism maybe due to organ specific differences in the initiation of translation by the virus internal ribosome entry site. == References ==