The clinical trial did show that bevacizumab reduced tumor volumes and showed an increase in progression free survival time. It was based on this data that the FDA chose to overrule the recommendation of the panel of advisers. This decision was lauded by patient advocacy groups and some oncologists. Other oncologists felt that granting approval for late-stage cancer therapies that did not prolong or increase the quality of life for patients would give license to pharmaceutical companies to ignore these important benchmarks when developing new late-stage cancer therapies.In 2010, before the FDA announcement, The National Comprehensive Cancer Network (NCCN) updated the NCCN Clinical Practice Guidelines for Oncology (NCCN Guidelines) for Breast Cancer to affirm the recommendation regarding the use of bevacizumab in the treatment of metastatic breast cancer.In 2011, the US Food and Drug Administration removed bevacizumab indication for metastatic breast cancer after concluding that the drug has not been shown to be safe and effective. The specific indication that was withdrawn was for the use of bevacizumab in metastatic breast cancer, with paclitaxel for the treatment of people who have not received chemotherapy for metastatic HER2-negative breast cancer. Counterfeit
On Tuesday, 14 February 2012, Roche and its U.S. biotech unit Genentech announced that counterfeit Avastin had been distributed in the United States. The investigation is ongoing, but differences in the outer packaging make identification of the bogus drugs simple for medical providers.
Magnesium (or sodium) sulfate is also used for testing aggregates for soundness in accordance with ASTM C88 standard, when there are no service records of the material exposed to actual weathering conditions. The test is accomplished by repeated immersion in saturated solutions followed by oven drying to dehydrate the salt precipitated in permeable pore spaces. The internal expansive force, derived from the rehydration of the salt upon re-immersion, simulates the expansion of water on freezing. Magnesium sulfate is also used to test the resistance of concrete to external sulfate attack (ESA). Aquaria
Magnesium sulfate heptahydrate is also used to maintain the magnesium concentration in marine aquaria which contain large amounts of stony corals, as it is slowly depleted in their calcification process. In a magnesium-deficient marine aquarium, calcium and alkalinity concentrations are very difficult to control because not enough magnesium is present to stabilize these ions in the saltwater and prevent their spontaneous precipitation into calcium carbonate. Double salts
Double salts containing magnesium sulfate exist. There are several known as sodium magnesium sulfates and potassium magnesium sulfates. A mixed copper-magnesium sulfate heptahydrate (Mg,Cu)SO4·7H2O was recently found to occur in mine tailings and has been given the mineral name alpersite. See also
Calcium sulfate
Magnesium chloride

References
External links
International Chemical Safety Cards—Magnesium Sulfate