Indiana vesiculovirus, formerly Vesicular stomatitis Indiana virus (VSIV or VSV) is a virus in the family Rhabdoviridae; the well-known Rabies lyssavirus belongs to the same family. VSIV can infect insects, cattle, horses and pigs. It has particular importance to farmers in certain regions of the world where it infects cattle. This is because its clinical presentation is identical to the very important foot and mouth disease virus.The virus is zoonotic and leads to a flu-like illness in infected humans. It is also a common laboratory virus used to study the properties of viruses in the family Rhabdoviridae, as well as to study viral evolution. Properties
Indiana vesiculovirus is the prototypic member of the genus Vesiculovirus of the family Rhabdoviridae. VSIV is an arbovirus, and its replication occurs in the cytoplasm. Natural VSIV infections encompass two steps, cytolytic infections of mammalian hosts and transmission by insects. In insects, infections are noncytolytic persistent. One confirmed vector of the virus is the phlebotomine sand fly Lutzomyia shannoni. The genome of VSIV is on a single molecule of negative-sense RNA that has 11,161 nucleotides in length, that encodes five major proteins: G protein (G), large protein (L), phosphoprotein (P), matrix protein (M) and nucleoprotein (N):
The VSIV G protein, aka VSVG, enables viral entry. It mediates viral attachment to an LDL receptor (LDLR) or an LDLR family member present on the host cell. Following binding, the VSIV-LDLR complex is rapidly endocytosed. It then mediates fusion of the viral envelope with the endosomal membrane.
Klismaphilia (or klysmaphilia), from the Greek words κλύσμα ("enema", from κατακλυσμός, "deluge, flood") and φιλία ("love"), is a paraphilia involving enjoyment of, and sexual arousal from, enemas. History
The term klismaphilia was coined in 1973 by Dr. Joanne Denko, an early investigator in this field, in her article "Klismaphilia: Enema as a Sexual Preference[:] Report of Two Cases," to describe the activities of some of her patients, whom she referred to as klismaphiliacs. Klismaphile has come into use as a synonym for klismaphiliac. Manifestation
Klismaphiles might gain pleasure from a large, water distended belly or the feeling of internal pressure. An enema fetish may include the sexual attraction to the equipment, processes, environments, situations, or scenarios, and some may be sexually aroused by the preparations, such as by the feel and smell of a latex rubber or plastic syringe, by the smell of soapsuds enema solution, or by preparing the recipient. Often, klismaphiles report discovering these desires after a chance administration of an enema sometime in their childhood, but some do report discovering these feelings later on. Klismaphiles can gain satisfaction of enemas through fantasies, by actually receiving or giving one, or through the process of eliminating steps to being administered one (e.g., under the pretense of being constipated). Usually, klismaphiles carry out normal lives and successfully engage in this behavior secretly. An enema can be an auxiliary to, or a substitute for, genital sexual activity.That some women use enemas while masturbating was documented by Alfred Kinsey in "Sexual Behavior in the Human Female."