and as of 2004 it was recommended to treat bacterial prostatitis by the NIH research network studying the condition.Levofloxacin and other fluoroquinolones have also been widely used for the treatment of uncomplicated community-acquired respiratory and urinary tract infections, indications for which major medical societies generally recommend the use of older, narrower spectrum drugs to avoid fluoroquinolone resistance development. Due to its widespread use, common pathogens such as Escherichia coli and Klebsiella pneumoniae have developed resistance. In many countries as of 2013, resistance rates among healthcare-associated infections with these pathogens exceeded 20%.Levofloxacin is also used as antibiotic eye drops to prevent bacterial infection. Usage of levofloxacin eye drops, along with an antibiotic injection of cefuroxime or penicillin during cataract surgery, has been found to lower the chance of developing endophthalmitis, compared to eye drops or injections alone. Pregnancy and breastfeeding
According to the FDA approved prescribing information, levofloxacin is pregnancy category C. This designation indicates that animal reproduction studies have shown adverse effects on the fetus and there are no adequate and well-controlled studies in humans, but the potential benefit to the mother may in some cases outweigh the risk to the fetus. Available data point to a low risk for the unborn child. Exposure to quinolones, including levofloxacin, during the first-trimester is not associated with an increased risk of stillbirths, premature births, birth defects, or low birth weight.Levofloxacin does penetrate into breastmilk, though the concentration of levofloxacin in the breastfeeding infant is expected to be low.
A congenital lip pit or lip sinus is a congenital disorder characterized by the presence of pits and possibly associated fistulas in the lips. They are often hereditary, and may occur alone or in association with cleft lip and palate, termed Van der Woude syndrome. Diagnosis
Classification
They are divided into three types based on their location:
commissural pits, which are small pits near the labial commissure of the mouth,
a pit in the upper lip, in which case it may be called a midline sinus of the upper lip, and
pits in the lower lip, in which case it may be called a congenital sinus of the lower lip.In some cases commissural pits have been reported in combination with preauricaluar pits, which are near the ear. Treatment
Lip pits do not usually require any treatment, although in some reported cases surgical excision has been used or if associated with a draining sinus tract. See also
Skin dimple

References


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