Mariks own initial research, published in 2017, showed a dramatic evidence of benefit, leading to the protocol becoming popular among intensive care physicians, especially after the protocol received attention on social media and National Public Radio, leading to criticism of science by press conference from the wider medical community. Subsequent independent research failed to replicate Mariks positive results, indicating the possibility that they had been compromised by bias. A systematic review of trials in 2021 found that the claimed benefits of the protocol could not be confirmed. Another more recent review found that "HAT therapy significantly reduced the duration of vasopressor use and improved the SOFA score but appeared not to have significant benefits in other outcomes for patients with sepsis. "Overall, the evidence for any role for vitamin C in the treatment of sepsis remains unclear as of 2021. References
External links

Sepsis at Curlie
SIRS, Sepsis, and Septic Shock Criteria Archived 17 February 2015 at the Wayback Machine
"Sepsis". MedlinePlus. U.S. National Library of Medicine.
Fissure of the nipple, colloquially referred to as "joggers nipple", is a condition that is the result of chafing of one or both nipples. This can occur in both men and women during physical exercise such as long-distance running where there is prolonged friction between the nipple and clothing. The issue is also commonly seen in surfers who do not wear rash guards or wetsuits. See also
Cracked nipple
List of cutaneous conditions

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