Occasionally, cocaine is mixed with adrenaline and sodium bicarbonate and used topically for surgery, a formulation called Moffetts solution.Cocaine hydrochloride (Goprelto), an ester local anesthetic, was approved for medical use in the United States in December 2017, and is indicated for the introduction of local anesthesia of the mucous membranes for diagnostic procedures and surgeries on or through the nasal cavities of adults. Cocaine hydrochloride (Numbrino) was approved for medical use in the United States in January 2020.The most common adverse reactions in people treated with Goprelto are headache and epistaxis. The most common adverse reactions in people treated with Numbrino are hypertension, tachycardia, and sinus tachycardia. Recreational
Cocaine is a central nervous system stimulant. Its effects can last from 15 minutes to an hour. The duration of cocaines effects depends on the amount taken and the route of administration. Cocaine can be in the form of fine white powder, bitter to the taste. Crack cocaine is a smokeable form of cocaine made into small "rocks" by processing cocaine with sodium bicarbonate (baking soda) and water.
The Musical, by David Massingham and Matthew Townend

Television
"Plague" (2003 Dead Zone episode)
"Plague" (2004 Deadwood episode)
"The Plague" (1994 Diagnosis: Murder episode)
"The Plague", second episode of the 1966 Doctor Who serial The Ark
"The Plague" (1996 Father Ted episode)
The Plague, English title of 2018 Spanish TV series La peste

Religion
Plagues of Egypt, the 10 calamities that God inflicted on Egypt in the book of Exodus
The seven plagues poured out from seven bowls in Revelation 15:5-16:21

Technology
Capacitor plague, a condition afflicting computer motherboards in which capacitors fail

See also
Plaque (disambiguation)