In the past, life expectancy was said to be around two years of age. However, with advances in seizure control, and treatments for respiratory illness, most children live well beyond that age. With other advances in therapy and the broader availability of services and equipment, some children with lissencephaly are able to walk with varying degrees of assistance and to perform other functions once thought too advanced. See also
Gyrification
CEP85L - gene associated with posterior predominant lissencephaly in a 2020 study

References
External links

Lissencephaly at NINDS
GeneReviews/NCBI/NIH/UW entry on DCX-Related Disorders
OMIM entries on DCX-Related Disorders
GeneReview/NIH/UW entry on LIS1 Lissencephaly
Posthitis (pronounced pos-THI-tis) is the inflammation of the foreskin (prepuce) of the penis. It is characterised by swelling and redness on the skin and it may be accompanied by a smelly discharge. The term posthitis comes from the Greek "posthe", meaning foreskin, and "-itis", meaning inflammation. Causes
Posthitis can have infectious causes such as bacteria or fungi, or non-infectious causes such as contact dermatitis or psoriasis. The inflammation may be caused by irritants in the environment. Common causative organisms include candida, chlamydia, and gonorrhea. The cause must be properly diagnosed before a treatment can be prescribed. A common risk factor is diabetes. Posthitis can lead to phimosis, the tightening of the foreskin which makes it difficult to retract over the glans. Posthitis can also lead to superficial ulcerations and diseases of the inguinal lymph nodes. Prevention
Hygiene, in particular the regular cleaning of the glans, is generally considered sufficient to prevent infection and inflammation of the foreskin. Full retraction of the foreskin may not be possible in boys younger than about ten years and some may not be able to fully retract their foreskin for cleaning until their late teens. Treatment
If contact dermatitis is suspected, soaps and other external irritants should be discontinued and a latex allergy should be investigated. The treatment depends on identification of the cause. Irritants in the environment should be removed.