Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure. It contains lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. Typically, it becomes an option once a person is doing well on the individual components. It is taken by mouth.Common side effects include dizziness, headache, cough, and feeling tired. Severe side effects may include angioedema and low blood pressure. Use during pregnancy may harm the baby.The combination was approved for medical use in the United States in 1989. It is on the World Health Organizations List of Essential Medicines. It is available as a generic medication. In 2020, it was the 50th most commonly prescribed medication in the United States, with more than 13 million prescriptions. References
External links
"Hydrochlorothiazide mixture with lisinopril". Drug Information Portal. U.S. National Library of Medicine.
This has a direct effect on the amount of oxygen and nutrients being able to supply the brain, which causes brain cells to die within minutes. "The middle cerebral arteries supply blood to the cortical areas involved in speech, language and swallowing. The left middle cerebral artery provides Brocas area, Wernickes area, Heschls gyrus, and the angular gyrus with blood". Therefore, in patients with Wernickes aphasia, there is typically an occlusion to the left middle cerebral artery.As a result of the occlusion in the left middle cerebral artery, Wernickes aphasia is most commonly caused by a lesion in the posterior superior temporal gyrus (Wernickes area). This area is posterior to the primary auditory cortex (PAC) which is responsible for decoding individual speech sounds. Wernickes primary responsibility is to assign meaning to these speech sounds. The extent of the lesion will determine the severity of the patients deficits related to language. Damage to the surrounding areas (perisylvian region) may also result in Wernickes aphasia symptoms due to variation in individual neuroanatomical structure and any co-occurring damage in adjacent areas of the brain. Diagnosis
Aphasia is usually first recognized by the physician who treats the person for his or her brain injury. Most individuals will undergo a magnetic resonance imaging (MRI) or computed tomography (CT) scan to confirm the presence of a brain injury and to identify its precise location.