In addition, affected individuals may have abnormally low levels of circulating red blood cells (anemia), a decrease in circulating blood platelets that assist in blood clotting functions (thrombocytopenia), abnormal liver function tests and/or inflammation of the blood vessels (vasculitis). Complications
Recurrent infection
Enlargement of the spleen causing too few red blood cells and platelets in the bloodstream
Enlarged lymph nodes
Skin hyperpigmentation
Cutaneous ulceration

Causes
The cause of Feltys syndrome is unknown, but it has been found to be more common in those with chronic rheumatoid arthritis. Some patients share the HLA-DR4 serotype. This syndrome is mostly present in people having extra articular manifestations of rheumatoid arthritis. People with this syndrome are at risk of infection because they have a low white blood cell count. Mechanism
The underlying pathogenesis of Feltys syndrome is not clear. Rheumatoid Arthritis
Rheumatoid arthritis is an autoimmune disease that is characterized by inflammation of the synovial joints due to attack by the bodys own immune system. In this condition, the white blood cells travel through the bloodstream to the synovial joints and release pro-inflammatory cytokines upon arrival. The result of this chemical release causes the synovial cells to release harmful chemicals in response as well as begin the growth of new blood vessels, forming a pannus. The pannus receives blood supply from the newly formed vessels and grows inward, invading the articular cartilage and bone within the joint. The damage to the once healthy tissue causes inflammation and ultimately fluid build-up in the joint.
Complication or complications may refer to:

Dramatic arts
"Complications" (CSI: Miami), an episode of CSI: Miami
"Complications" (Terminator: The Sarah Connor Chronicles), an episode of Terminator: The Sarah Connor Chronicles
Complications (TV series), a 2015 USA Network television series starring Jason OMara

Medicine
Complication (medicine), an unfavorable evolution of a disease, health condition or  medical treatment

Music
Albums
Complications - Trilogy of Intricacy, a 2005 EP by Norwegian progressive metal band Age of Silence
Complications (Dover album), a 2015 album by Spanish rock band Dover

Songs
"Complication", a 1999 song by Nine Inch Nails from The Fragile
"Complications", a 2008 song by deadmau5 from Random Album Title

Technology
Complication (horology), a clock display other than the time
Smartwatch complication Complication (horology)#Use in smartwatches