Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the fatty layer under the skin – panniculus adiposus). Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue. Restated, an inflammatory disorder primarily localized in the subcutaneous fat is termed a "panniculitis", a group of disorders that may be challenging both for the clinician and the dermatopathologist. : 487  The general term for inflammation of any adipose tissue is steatitis. Signs and symptoms
Panniculitis can also be classified based on the presence or absence of systemic symptoms. Panniculitis without systemic disease can be a result of trauma or cold. Panniculitis with systemic disease can be caused by:

connective tissue disorders such as lupus erythematosus or scleroderma;
lymphoproliferative disease such as lymphoma or histiocytosis;
pancreatitis or pancreatic cancer;
sarcoidosis with cutaneous involvement (seen in up to 20 percent);
Alpha 1-antitrypsin deficiency
Crohns diseaseThis is not a complete list of possible causes. Associated conditions
Lipoatrophy or lipodystrophy (the loss of subcutaneous adipose tissue) can occur in any of these conditions.
Amitriptyline/chlordiazepoxide, sold under the brand names Limbitrol and Limbitrol DS, is a combination of amitriptyline (Elavil), a tricyclic antidepressant, and chlordiazepoxide (Librium), a benzodiazepine, which is approved for the treatment of moderate to severe depression associated with moderate to severe anxiety in the United States. It contains 12.5 to 25 mg amitriptyline and 5 to 10 mg chlordiazepoxide per tablet. == References ==