Diphtheria is an infection caused by the bacterium Corynebacterium diphtheriae. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks more than 10% of those diagnosed with the disease may die. Signs and symptoms may vary from mild to severe and usually start two to five days after exposure. Symptoms often come on fairly gradually, beginning with a sore throat and fever. In severe cases, a grey or white patch develops in the throat. This can block the airway and create a barking cough as in croup. The neck may swell in part due to enlarged lymph nodes. A form of diphtheria which involves the skin, eyes or genitals also exists. Complications may include myocarditis, inflammation of nerves, kidney problems, and bleeding problems due to low levels of platelets. Myocarditis may result in an abnormal heart rate and inflammation of the nerves may result in paralysis.Diphtheria is usually spread between people by direct contact or through the air. It may also be spread by contaminated objects. Some people carry the bacterium without having symptoms, but can still spread the disease to others. The three main types of C. diphtheriae cause different severities of disease. The symptoms are due to a toxin produced by the bacterium. Diagnosis can often be made based on the appearance of the throat with confirmation by microbiological culture. Previous infection may not protect against infection.A diphtheria vaccine is effective for prevention and available in a number of formulations.
The effect of ephedrine is delayed and the improvement occurs over a period of months.Salbutamol, a selective β(2)-adrenergic receptor agonist, has been found, in adults, to have fewer side effects than Ephedrine and to be more easily obtained in some countries. It has been trialed in children with positive resultsAs of 2022, the standard of care for DOK7  CMS is either ephedrine or salbutamol. People
Two brothers with apparent myasthenic syndrome with a seemingly circadian off/on cycle, living near Quetta, Pakistan were nicknamed the solar kids, because their condition resulted in an inability to move from approximately sunset to sunrise, while their daytime motor abilities were seemingly normal. Doctors observed that some "factor" seemed to become exhausted in the course of normal diurnal activities, and was "recharged" over the period of inertia and sleep. The father first sought help from spiritual healers, then turned to Western medicine. A younger brother of the two had also begun to manifest the same symptoms. The family had other children, two daughters and one son, who were unaffected. The "solar kids" condition, despite extensive testing, was said to be undiagnosed as of 2016, and assumed to be genetic, as their parents were cousins. Samples of their genetic material were to be sent to the UK for analysis. See also
Congenital disorder
Myasthenia gravis
Lambert-Eaton syndrome

References
External links
Congenital Myasthenic Syndromes
About Congenital Myasthenic Syndrome From the Mayo Clinic
Treatment for Congenital Myasthenic Syndromes From the Mayo Clinic