Obstruction  may refer to:

Places
Obstruction Island, in Washington state
Obstruction Islands, east of New Guinea

Medicine
Obstructive jaundice
Obstructive sleep apnea
Airway obstruction, a respiratory problem
Recurrent airway obstruction
Bowel obstruction, a blockage of the intestines. Gastric outlet obstruction
Distal intestinal obstruction syndrome
Congenital lacrimal duct obstruction
Bladder outlet obstruction

Politics and law
Obstruction of justice, the crime of interfering with law enforcement
Obstructionism, the practice of deliberately delaying or preventing a process or change, especially in politics
Emergency Workers (Obstruction) Act 2006

Science and mathematics
Obstruction set in forbidden graph characterizations, in the study of graph minors in graph theory
Obstruction theory, in mathematics
Propagation path obstruction
Single Vegetative Obstruction Model

Sports
Obstruction (baseball), when a fielder illegally hinders a baserunner
Obstructing the field

See also
The Five Obstructions, a 2003 film
USS Obstructor, an American minelayer ship used in World War II
Therefore, the mutation in the α4 subunit could lead to reduced GABA release, causing hyperexcitability. Pathophysiology
CHRNA4
The first mutation associated with ADNFLE is a serine to phenylalanine transition at position 248 (S248F), located in the second transmembrane spanning region of the gene encoding a nicotinic acetylcholine receptor α4 subunit. Using the numbering based on the human CHRNA4 protein, this mutation is called S280F. Receptors containing this mutant subunit are functional, but desensitize at a much faster pace compared to wild-type only receptors. These mutant containing receptors also recover from desensitization at a much slower rate than wild-type only receptors. These mutant receptors also have a decreased single channel conductance than wild-type and have a lower affinity for acetylcholine. Also importantly, this mutation along with the others in CHRNA4 produce receptors less sensitive to calcium.The second discovered ADNFLE mutation was also in CHRNA4. This mutation, L259_I260insL, is caused by the insertion of three nucleotides (GCT) between a stretch of leucine amino acids and an isoleucine. As with the S248F mutation, the L259_I260insL mutation is located in the second transmembrane spanning region. Electrophysiological experiments have shown that this mutant is tenfold more sensitive to acetylcholine than wild-type. Calcium permeability, however is notably decreased in mutant compared to wild-type containing receptors. Furthermore, this mutant shows slowed desensitization compared to both wild-type and S248F mutant receptors.Also located in the second transmembrane spanning region, the S252L mutation has also been associated with ADNFLE.