General asthenia occurs in many chronic wasting diseases (such as tuberculosis and cancer), sleep disorders or chronic disorders of the heart, lungs or kidneys, and is probably most marked in diseases of the adrenal gland. Asthenia may be limited to certain organs or systems of organs, as in asthenopia, characterized by ready fatiguability. Asthenia is also a side effect of some medications and treatments, such as Ritonavir (a protease inhibitor used in HIV treatment). Differentiating psychogenic (perceived) asthenia and true asthenia from myasthenia is often difficult, and in time apparent psychogenic asthenia accompanying many chronic disorders is seen to progress into a primary weakness.Myasthenia (my- from Greek μυο meaning "muscle" + -asthenia ἀσθένεια meaning "weakness"), or simply muscle weakness, is a lack of muscle strength. The causes are many and can be divided into conditions that have either true or perceived muscle weakness. True muscle weakness is a primary symptom of a variety of skeletal muscle diseases, including muscular dystrophy and inflammatory myopathy. It occurs in neuromuscular diseases, such as myasthenia gravis. Types
Muscle fatigue can be central, neuromuscular, or peripheral muscular. Central muscle fatigue manifests as an overall sense of energy deprivation, and peripheral muscle weakness manifests as a local, muscle-specific inability to do work. Neuromuscular fatigue can be either central or peripheral. Central fatigue
The central fatigue is generally described in terms of a reduction in the neural drive or nerve-based motor command to working muscles that results in a decline in the force output.
In adults, evidence of the effectiveness of various non-surgical interventions is less clear.Both positive fusional vergence (PFV) and negative fusional vergence (NFV) can be trained, and vergence training should normally include both. Surgical correction options are also available, but the decision to proceed with surgery should be made with caution as convergence insufficiency generally does not improve with surgery. Bilateral medial rectus resection is the preferred type of surgery. However, the patient should be warned about the possibility of uncrossed diplopia at distance fixation after surgery. This typically resolves within one to three months postoperatively. The exophoria at near often recurs after several years, although most patients remain asymptomatic. Reading difficulty
In some cases, convergence Insufficiency can be the underlying cause of difficulty learning to read. As a result of the eyes not converging on the same point for sustained periods of time when reading, words can appear blurry or double because the brain is receiving two different images. Convergence insufficiency is not a learning disability. However, some children with the condition who are struggling to learn to read can be confused for having dyslexia due to difficulty learning to read. Children struggling with symptoms such as letters appearing blurry or double and experience tiredness or headaches when reading should consult an optometrist. Prevalence
Among fifth and sixth grade children convergence insufficiency is 13%. In studies that used standardized definitions of convergence insufficiency, investigators have reported a prevalence of 4.2% to 6% in school and clinic settings.