1988: 10 families worldwide were identified as having CRV (now known as RVCL or RVCL-S)
1991: Related disease reported, HERNS (Hereditary Endiotheliopathy with Retinopathy, Nephropathy and Stroke – UCLA
1998: Related disease reported, HRV (Hereditary Retinal Vasculopathy) – Leiden University, Netherlands
2001: Localized to Chromosome 3. 2007: The specific genetic defect in all of these families was discovered in a single gene called TREX1 on chromosome 3. 2008: Name changed to AD-RVCL Autosomal Dominant-Retinal Vasculopathy with Cerebral Leukodystrophy
2009: Testing for the disease available to persons 21 and older
2011: 20 families worldwide were identified as having CRV
2012: Obtained mouse models for further research and to test therapeutic agents
2021: At least 42 families and 200 patients worldwide are known to have RVCL (or RVCL-S). [1]
2021: Dr. Jonathan Miner of the University of Pennsylvania (Penn) initiates the second clinical trial for RVCL, in collaboration with Dr. Andria Ford of WashU. Miner also establishes an International Registry in collaboration with colleagues. References


== External links ==
Sodium thiosulfate (sodium thiosulphate) is an inorganic compound with the formula Na2S2O3.xH2O. Typically it is available as the white or colorless pentahydrate, Na2S2O3·5H2O. The solid is an efflorescent (loses water readily) crystalline substance that dissolves well in water.Sodium thiosulfate is used in gold mining, water treatment, analytical chemistry, the development of silver-based photographic film and prints, and medicine. The medical uses of sodium thiosulfate include treatment of cyanide poisoning and pityriasis. It is on the World Health Organizations List of Essential Medicines. Uses
Sodium thiosulfate is used predominantly in industry. For example, it is used to convert dyes to their soluble leuco form. It is also used to bleach "wool, cotton, silk, ...soaps, glues, clay, sand, bauxite, and... edible oils, edible fats, and gelatin." Medical uses
Sodium thiosulfate is used in the treatment of cyanide poisoning. Other uses include topical treatment of ringworm and tinea versicolor, and treating some side effects of hemodialysis and chemotherapy. Photographic processing
Silver halides, e.g., AgBr, typical components of photographic emulsions, dissolve upon treatment with aqueous thiosulfate.This application as a photographic fixer was discovered by John Herschel. It is used for both film and photographic paper processing; the sodium thiosulfate is known as a photographic fixer, and is often referred to as hypo, from the original chemical name, hyposulphite of soda. Ammonium thiosulfate is typically preferred to sodium thiosulfate for this application.