Lepromatous leprosy is a form of leprosy characterized by pale macules in the skin. : 346 It results from the failure of Th1 cell activation which is necessary to eradicate the mycobacteria (Th1 response is required to activate macrophages that engulf and contain the disease). In lepromatous leprosy, TH2 response is turned on, and because of reciprocal inhibition (IL-4; IL-10), the cell-mediated response (TH1) is depressed. Lepromatous leprosy,  in contrast to the tuberculoid form of leprosy,  is characterized by the absence of epithelioid cells in the lesions. In this form of leprosy Mycobacterium leprae are found in lesion in  large numbers. This is the most unfavorable clinical variant of leprosy.This debilitating form of leprosy begins to spread causing the eyebrows to disappear and spongy tumor like swellings appear on the face and body. The disease attacks the internal organs, bones, joints and marrow of the body resulting in physical degeneration. The result is deformity with loss of feeling in the fingers and toes which eventually fall off. Contrary to popular belief, both forms of leprosy are curable, with the lepromatous form classically treated with antibiotics dapsone, rifampin and clofazimine for as long as 2–5 years, but if left untreated the person may die up to 20 or 30 years from its inception.Early detection of the disease is of utmost importance, since severe physical and neurological damage are irreversible even if cured (e.g. blindness, loss of digits/limbs/sensation).
Hematocolpos is a medical condition in which the vagina is pooled with menstrual blood due to multiple factors leading to the blockage of menstrual blood flow. The medical definition of hematocolpos is an accumulation of blood within the vagina. It is often caused by the combination of menstruation with an imperforate hymen. It is sometimes seen in Robinow syndrome, uterus didelphys, or other vaginal anomalies. A related disorder is hematometra, where the uterus fills with menstrual blood. It presents after puberty as primary amenorrhoea, recurrent pelvic pain with a pelvic mass. This can be caused by a congenital stenosis of the cervix, or by a complication of a surgical treatment. Mucometrocolpos is the accumulation of mucous secretions behind an imperforate hymen. Mucometrocolpos can sometimes cause abdominal distention. Symptoms
On and off lower abdominal pain lasting more than a week 
Pain with cramping, with episodes of worse pain in between
Vomiting without blood or bile
Abdominal bloating and distention 
Constipation and changes in urine output 
Tender breasts 
Vaginal bleeding or discharge
Severe cyclic pelvic pain
Urinary retention

Causes
There are four possible causes of hematocolpos
Imperforate hymen: An imperforate hymen is a medical condition where the female is born with a hymen that spans the entire diameter of the vagina, with no opening to the outside. An imperforate hymen may be diagnosed at any age. However, when a girl hits puberty, this type of hymen blocks the blood from flowing out and the bloods pools in the vagina.