A meta-analysis of seven clinical trials of critically ill COVID-19 participants, each treated with one of three different corticosteroids found a statistically significant reduction in death. The largest reduction was obtained with dexamethasone (36% compared to placebo).In September 2020, the European Medicines Agency (EMA) endorsed the use of dexamethasone in adults and adolescents, from twelve years of age and weighing at least 40 kilograms (88 lb), who require supplemental oxygen therapy. Dexamethasone can be taken by mouth or given as an injection or infusion (drip) into a vein.In November 2020, the Public Health Agency of Canadas Clinical Pharmacology Task Group recommended dexamethasone for hospitalized patients requiring mechanical ventilation. Although dexamethasone, and other glucocorticoids, reduce mortality in COVID-19 they have also been associated with an increased risk of secondary infections, secondary infections being a significant issue in critically ill COVID-19 patients.The mechanism of action of dexamethasone involves suppression of late-stage interferon type I programs in severe COVID-19 patients. Endocrine
Dexamethasone is the treatment for the very rare disorder of glucocorticoid resistance.In adrenal insufficiency and Addisons disease, dexamethasone is prescribed when the patient does not respond well to prednisone or methylprednisolone.It can be used in congenital adrenal hyperplasia in older adolescents and adults to suppress Adrenocorticotropic hormone (ACTH) production. It is typically given at night. Pregnancy
Dexamethasone may be given to women at risk of delivering prematurely to promote maturation of the fetus lungs.
A myoma is a type of tumor that involves muscle cells. There are two main types of myoma: 

Leiomyomas which occur in smooth muscle. They most commonly occur as uterine fibroids, but may also form in other locations. Rhabdomyomas which occur in striated muscle. They are rare tumors, occur in childhood and often become malignant.Whether or not angiomyomas are a type of leiomyoma or a separate entity is disputed as of 2014.Myomas are benign tumors of the uterus that can affect the fertility of a woman depending mainly on three factors:

Size (cut off value 4-5 cm)
Number
Location (they can be intramural, subserous or submucous). Submucous ones are worst from a fertility point of view, while subserous are less dangerous.Some of the most common symptoms are: abundant menstrual bleeding, longer menstrual periods, pelvic pressure, constipation, a need to urinate continuously. References


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