For example, rifampicin reduced the AUC by 60% in a study.Upadacitinib seems to be a weak inducer of CYP3A4, as it lowers concentrations of other substrates of this enzyme (such as the midazolam AUC by 26%). It has no effect on substrates of CYP1A2, CYP2B6, CYP2C9, CYP2C19 or CYP2D6. Side effects
Common side effects are upper respiratory tract infections such as common cold and sinus infections (13.5% of patients in studies), nausea (3.5%), cough (2.2%), fever, and increased liver enzymes. Serious side effects include infections, including life-threatening ones, such as pneumonia, cellulitis, tuberculosis, as well as shingles and other herpes infections. Pharmacology
Mechanism of action
The Janus kinases (JAKs) are a family of cytoplasmic tyrosine kinases whose function is to transduce cytokine-mediated signals via the JAK-STAT pathway. There are four JAK subtypes, each of which has overlapping receptor responsibilities. Inhibitors of this enzyme family (jakinibs) have shown efficacy in treating certain inflammatory and autoimmune diseases such as rheumatoid arthritis and Crohns disease. However, the first generation of these drugs, tofacitinib and ruxolitinib, lacked subtype selectivity, affecting JAK1/JAK3 and JAK1/JAK2 respectively. This has led to dose-limiting side effects in this otherwise promising class of drugs. Upadacitinib is a second generation Janus kinase inhibitor that is selective for the JAK1 subtype of this enzyme over the JAK2 (74-fold), JAK3 (58-fold) and tyrosine kinase 2 subtypes. Pharmacokinetics
After oral intake, upadacitinib reaches highest concentrations in the blood plasma after two to four hours. A fatty meal has no clinically relevant effect on its resorption.
Significance
Kerala state depends on migrant workers for the various jobs needed. The dependence on Migrant labourers in Kerala is found mainly in the field of construction. The city of Kollam and other places like Punalur, Paravur in Kollam district, Perumbavoor, Thrissur etc. are slowly becoming overwhelmed with a number of migrants from North India. The migrant labours in places like Kollam have started scoring top marks in literacy equivalent examination. So an institute for developing the unskilled domestic labours as well as migrant labourers has become an essential need in Kerala. The main aim behind this institute is to train masons to upgrade their skills and get a certification from the Britain-based organisation City and Guilds.The flagship project of KASE is the Centre of Excellence in Construction and Infrastructure by the name Indian Institute of Infrastructure and Construction (IIIC). Established in a 9-acre state-of the-art campus at Chavara, Kollam District, Kerala, the objectives of IIIC are broadly to:

Establish a world class Skill Centre, as centre of excellence, for imparting international quality skill sets to the personnel in construction industry of all cadres, right from the labourers to the top managerial personnel under three major categories viz., technician, supervisory and managerial categories. Maximize the reach of the Skill Centre in terms of capacity intake as well as sub sectors covered and the area of reach.