Notable cases
A dwarf of Punt (ancient Somalia) was given by the Chief clans as partial tribute to the last ruler of Ancient Egypts Old Kingdom, Pepi II Neferkare (6th Dynasty, circa 2125–2080 BC); it could be inferred that this person was also microcephalic. In a letter preserved at the British Museum, the young king gives instructions by letter, "Harkhuf! The men in your service [escorts; soldiers; sailors; guards, etc.] ought pay sincere care with the dwarfs head while sleeping during the voyage to the palace" (so that it does not fall off). At the same time, it could be for other reasons unrelated to microcephaly, etc. Triboulet, a jester of duke René of Anjou (not to be confused with the slightly later Triboulet at the French court). Jenny Lee Snow and Elvira Snow, whose stage names were Pip and Flip, respectively, were sisters with microcephaly who acted in the 1932 film Freaks. Schlitze "Schlitzie" Surtees, possibly born Simon Metz, was a widely known sideshow performer and actor, who also appeared in Freaks. Lester "Beetlejuice" Green, a member of radio host Howard Sterns Wack Pack. See also
Anencephaly (Usually rapidly fatal)
Cerebral rubicon
Hydrocephaly
Macrocephaly
Seckel syndrome
Achalasia microcephaly

References
External links

Microcephaly at NINDS
NINDS Overview
As it is so heavily bound to plasma proteins haemodialysis is unlikely to be helpful in cases of overdose.Early symptoms of overdose can include:

It is worth noting, however, that may of these symptoms are also indicative of kidney failure and hence may be masked by the patients condition.Late symptoms of overdose include:

Mechanism of action
Like 1,25-dihydroxyergocalciferol, paricalcitol acts as an agonist at the vitamin D receptor and thereby lowers parathyroid hormone levels in the blood. Pharmacokinetics
The plasma concentration of paricalcitol decreases rapidly and log-linearly within two hours after initial intravenous administration. Therefore, it is not expected to accumulate with multiple dosing, since paricalcitol is usually given no more frequently than every other day (3 times per week). == References ==