Pharmacokinetics
Molecular weight (daltons)             330.7
% Bioavailability    47-70%
Bioavailability with end-stage renal disease   43 - 46%
% Protein binding                      91–99
Volume of distribution (L/kg)          0.07 – 0.2Volume of distribution may be higher in patients with cirrhosis or nephrotic syndrome
Excretion
% Excreted in urine (% of total dose)   60 - 90
% Excreted unchanged in urine (% of total dose)         53.1 - 58.8 
% Excreted in feces (% of total dose) 7 - 9
% Excreted in bile (% of total dose) 6 - 9
Approximately 10% is metabolized by the liver in healthy individuals, but this percentage may be greater in individuals with severe kidney failure 
Renal clearance (mL/min/kg)  2.0
Elimination half-life (hrs)   2Prolonged in congestive heart failure (mean 3.4 hrs)
Prolonged in severe kidney failure (4 - 6 hrs) and anephric patients (1.5-9 hrs)
Time to peak concentration (hrs)
Intravenous administration    0.3
Oral solution    0.83
Oral tablet     1.45The pharmacokinetics of furosemide are apparently not significantly altered by food.No direct relationship has been found between furosemide concentration in the plasma and furosemide efficacy. Efficacy depends upon the concentration of furosemide in urine. Names
Furosemide is the INN and BAN. The previous BAN was frusemide.
Class I is the strongest, or superpotent. Class VII is the weakest and mildest. Class I
Very potent: up to 600 times stronger than hydrocortisone

Clobetasol propionate 0.05% (Dermovate)
Betamethasone dipropionate 0.25% (Diprolene)
Halobetasol propionate 0.05% (Ultravate, Halox)
Diflorasone diacetate 0.05% (Psorcon)

Class II
Fluocinonide 0.05% (Lidex)
Halcinonide 0.05% (Halog)
Amcinonide 0.05% (Cyclocort)
Desoximetasone 0.25% (Topicort)

Class III
Triamcinolone acetonide 0.5% (Kenalog, Aristocort cream)
Mometasone furoate 0.1% (Elocon, Elocom ointment)
Fluticasone propionate 0.005% (Cutivate)
Betamethasone dipropionate 0.05% (Diprosone)
Halometasone 0.05%

Class IV
Fluocinolone acetonide 0.01-0.2% (Synalar, Synemol, Fluonid)
Hydrocortisone valerate 0.2% (Westcort)
Hydrocortisone butyrate 0.1% (Locoid)
Flurandrenolide 0.05% (Cordran)
Triamcinolone acetonide 0.1% (Kenalog, Aristocort A ointment)
Mometasone furoate 0.1% (Elocon cream, lotion)

Class V
Fluticasone propionate 0.05% (Cutivate cream)
Desonide 0.05% (Tridesilon, DesOwen ointment)
Fluocinolone acetonide 0.025% (Synalar, Synemol cream)
Hydrocortisone valerate 0.2% (Westcort cream)

Class VI
Alclometasone dipropionate 0.05% (Aclovate cream, ointment)
Triamcinolone acetonide 0.025% (Aristocort A cream, Kenalog lotion)
Fluocinolone acetonide 0.01% (Capex shampoo, Dermasmooth)
Desonide 0.05% (DesOwen cream, lotion)

Class VII
The weakest class of topical steroids. Has poor lipid permeability, and can not penetrate mucous membranes well. Hydrocortisone 2.5% (Hytone cream, lotion, ointment)
Hydrocortisone 1% (Many over-the-counter brands)

Five-class System
Japan rates topical steroids from 1 to 5, with 1 being strongest. Four-class System
Many countries, such as the United Kingdom, Germany, the Netherlands, New Zealand, recognize 4 classes. In the United Kingdom and New Zealand I is the strongest, while in Continental Europe, class IV is regarded as the strongest.