For optimal use, if used as a suppository, it is recommended that bisacodyl be given after breakfast to synchronize with the gastrocolic reflex. Two suppositories can be inserted at once if a very strong, purgative, enema-like result is needed. A few hours after the initial evacuation, there can be a secondary action which will continue as long as there is unexpelled bisacodyl present in the rectum. As a commercially prepared micro-enema, it is usually effective in 5 to 20 minutes. Mechanism of action
Bisacodyl works by stimulating enteric neurons to cause peristalsis, i.e., colonic contractions. It is also a contact laxative; it increases fluid and salt secretion. The action of bisacodyl on the small intestine is negligible; stimulant laxatives mainly promote evacuation of the colon. See also
Diphenyl-2-pyridylmethane
Cyclofenil

References
External links
|Bisacodyl,00.html Bisacodyl at Drugdigest.org
Bisacodyl Consumer Drug Information
Dulcolax Laxative
Dulcoflex Tablet Uses in Hindi
Tramadol/paracetamol, also known as tramadol/acetaminophen and sold under the brand name Ultracet, is a fixed-dose combination medication used for the treatment of moderate to severe pain. It contains tramadol hydrochloride and paracetamol. It is taken by mouth. References
External links
"Acetaminophen mixture with tramadol". Drug Information Portal. U.S. National Library of Medicine.