To reduce pain with intramuscular injections, ceftriaxone may be reconstituted with lidocaine.The syn-configuration of the methoxyoxime moiety confers resistance to beta-lactamase enzymes produced by many Gram-negative bacteria. The stability of this configuration results in increased activity of ceftriaxone against otherwise resistant Gram-negative bacteria. In place of the easily hydrolyzed acetyl group of cefotaxime, ceftriaxone has a metabolically stable thiotriazinedione moiety. Research
Ceftriaxone has also been investigated for efficacy in preventing relapse to cocaine addiction.Ceftriaxone seems to increase excitatory amino acid transporter-2 pump expression and activity in the central nervous system, so has a potential to reduce glutamatergic toxicity.Ceftriaxone has been shown to have neuroprotective properties in a number of neurological disorders, including spinal muscular atrophy and amyotrophic lateral sclerosis (ALS). Despite earlier negative results in the 1990s, a large clinical trial was undertaken in 2006 to test ceftriaxone in ALS patients, but was  stopped early after it became clear that the results would not meet the predetermined criteria for efficacy. References
External links
"Ceftriaxone". Drug Information Portal. U.S. National Library of Medicine.
Undifferentiated connective tissue disease (UCTD) is a disease in which the body mistakenly attacks its own tissues. It is diagnosed when there is evidence of an existing autoimmune condition which does not meet the criteria for any specific autoimmune disease, such as systemic lupus erythematosus or scleroderma. Latent lupus and incomplete lupus are alternative terms that have been used to describe this condition.The term is sometimes used interchangeably with mixed connective tissue disease, an overlap syndrome. However, MCTD is thought by some researchers to be a clinically distinct entity and is strongly associated with the presence of high titers of ribonucleoprotein (RNP) antibodies.It is estimated that up to 25 percent of people with systemic autoimmune disease could be considered to have UCTD. Signs and symptoms
Disease presentation varies widely from patient to patient, as UCTD is by definition nonspecific. Symptoms typically include constitutional complaints that are common to connective tissue diseases such as fatigue, a general sense of feeling unwell, and fever. Other symptoms associated with UCTD include:
dry eyes
dry mouth
hair loss
joint inflammation
joint pain
oral ulcers
positive ANA test
raynauds phenomenon
sun sensitive rashClinical presentation in some people diagnosed with UCTD may show: 
a decrease in white blood cell count in the blood
anemia
abnormal nerve sensations in the extremities
inflammation of the lining of the heart and/or lungs
a decrease in platelet countLung involvement, such as nonspecific interstitial pneumonia, is a possible disease complication. Diagnosis
There is no official diagnostic criteria for UCTD. Diagnostic testing generally aims to determine whether a patient has a definite or undifferentiated connective tissue disease.