As of 2008 and 2017, over-the-counter antihistamines were not recommended by the American Academy of Sleep Medicine for treatment of chronic insomnia "due to the relative lack of efficacy and safety data". Neither version of their guidelines explicitly included or mentioned doxylamine, although diphenhydramine was discussed. A 2015 systematic review of over-the-counter sleep aids including doxylamine found little evidence to inform the use of doxylamine for treatment of insomnia.A major systematic review and network meta-analysis of medications for the treatment of insomnia published in 2022 found that doxylamine had an effect size (standardized mean difference (SMD)) against placebo for treatment of insomnia at 4 weeks of 0.47 (95% CI 0.06 to 0.89). The certainty of evidence was rated as moderate. No data were available for doxylamine in terms of longer-term treatment (3 months). For comparison, the other sedating antihistamines assessed, doxepin and trimipramine, had effect sizes (SMD) at 4 weeks of 0.30 (95% CI –0.05 to 0.64) (very low certainty evidence) and 0.55 (95% CI –0.11 to 1.21) (very low certainty evidence), respectively.Doses of doxylamine that have been used for sleep range from 5 to 50 mg, with 25 mg being the typical dose. Morning sickness
Doxylamine is used in the combination drug pyridoxine/doxylamine to treat morning sickness (nausea and vomiting of pregnancy). It is the only medication approved by the United States Food and Drug Administration for the treatment of morning sickness.
The posterior division gives off only one branch, which is the saphenous nerve. Articular branches
Hip joint is supplied by nerve to the rectus femoris. Knee joint is supplied by the nerves to the three vasti. The nerve to vastus medialis is particularly thick because it contains the proprioceptive fibres from the knee joint. This is in accordance to the Hiltons law. Vascular branches
Branches to the femoral artery and its branches. Clinical significance
Signals from the femoral nerve and its branches can be blocked to interrupt transmission of pain signal from the innervation area, by performing a regional nerve blockage. Some of the nerve blocks that work by affecting the femoral nerve are the femoral nerve block, the fascia iliac block and the 3-in-1 nerve block. Femoral nerve blocks are very effective.During pelvic surgery and abdominal surgery, the femoral nerve must be identified early on to protect it from iatrogenic nerve injury.The femoral nerve stretch test can be performed to identify the compression of spinal nerve roots. The test is positive if thigh pain increases.