As the larvae migrate through tissue and vessels, the bodys inflammatory response results in edema, muscle pain, fever, and weakness. A classic sign of trichinosis is periorbital edema, swelling around the eyes, which may be caused by vasculitis. Splinter hemorrhage in the nails is also a common symptom.They may very rarely cause enough damage to produce serious neurological deficits (such as ataxia or respiratory paralysis) from worms entering the central nervous system (CNS), which is compromised by trichinosis in 10–24% of reported cases of cerebral venous sinus thrombosis, a very rare form of stroke (three or four cases per million annual incidence in adults). Trichinosis can be fatal depending on the severity of the infection; death can occur 4–6 weeks after the infection, and is usually caused by myocarditis, encephalitis, or pneumonia. Cause
The classical agent is T. spiralis (found worldwide in many carnivorous and omnivorous animals, both domestic and sylvatic (wild), but seven primarily sylvatic species of Trichinella also are now recognized:

Species and characteristics
T. spiralis is most adapted to swine, most pathogenic in humans, and is cosmopolitan in distribution. T. britovi is the second-most common species to infect humans; it is distributed throughout Europe, Asia, and northern and western Africa, usually in wild carnivores, crocodiles, birds, wild boar, and domesticated pigs. T. murrelli also infects humans, especially from black bear meat; it is distributed among wild carnivores in North America.
Christina Rossetti, English Victorian-era poet
Dame Maggie Smith, British actress
Mary Webb, British novelist and poet
Wendy Williams, American TV show host
Act Yasukawa, Japanese Professional wrestler. Literature
In Italo Svevos novel Zenos Conscience, character Ada develops the disease. Ern Malley was an acclaimed Australian poet whose work was not published until after his death from Graves disease in 1943. However, Malleys existence and entire biography was actually later revealed to be a literary hoax. Research
Agents that act as antagonists at thyroid stimulating hormone receptors are currently under investigation as a possible treatment for Graves disease. References
External links
"Graves disease". Genetics Home Reference. U.S. National Library of Medicine. https://www.ncbi.nlm.nih.gov/gene/?term=graves about graves on ncbi