Spasticity
Clonidine has some role in the treatment of spasticity, acting principally by inhibiting excessive sensory transmission below the level of injury. Its use, however, is mainly as a second or third line agent, due to side effects such as hypotension, bradycardia, and drowsiness. Other uses
Clonidine also has several off-label uses, and has been prescribed to treat psychiatric disorders including stress, sleep disorders,  hyperarousal caused by post-traumatic stress disorder, borderline personality disorder, and other anxiety disorders. Clonidine is also a mild sedative, and can be used as premedication before surgery or procedures. Its epidural use for pain during heart attack, and postoperative and intractable pain has also been studied extensively. Clonidine can be used in restless legs syndrome. It can also be used to treat facial flushing and redness associated with rosacea. It has also been successfully used topically in a clinical trial as a treatment for diabetic neuropathy. Clonidine can also be used for migraine headaches and hot flashes associated with menopause. Clonidine has also been used to treat refractory diarrhea associated with irritable bowel syndrome, fecal incontinence, diabetes, diarrhea associated with opioid withdrawal, intestinal failure, neuroendocrine tumors, and cholera. Clonidine can be used in the treatment of Tourette syndrome (specifically for tics).
Serostim (recombinant DNA somatropin) is Seronos brand name prescription drug form of synthetic growth hormone, marketed for HIV-associated wasting.In December 2007, the U.S. District Court of Massachusetts - in a class-action lawsuit that involved Merck Serono and Serostim - fined Serono a total of $704 million in criminal and civil liabilities for enacting "illegal schemes to promote, market and sell its drug." References
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