The following are specific characteristics:
Malformed or absent (aplasia) thumb
A thumb that looks more like a finger
Partial or complete absence of a radius
Shortening and radial deviation of the forearms
Triphalangeal thumb
Duplication of the thumb (preaxial polydactyly)

Other Various Symptoms
People with the combination of Duane anomaly and radial ray malformations may have a variety of other signs and symptoms. These features include:
Unusually shaped ears
Hearing loss
Heart and kidney defects
A distinctive facial appearance
An inward- and downward-turning foot (a clubfoot)
Fused vertebrae. Causes
Genetics
Duane-radial ray syndrome is caused by mutations in the SALL4 gene which is a part of a group of genes called the SALL family. This gene plays an important role in embryonic development by providing instructions to make proteins that are involved in the formation of tissues and organs. SALL proteins act as transcription factors in that they attach themselves to certain regions in DNA in order to help control certain gene activities. Due to the mutations in the SALL4 gene, proteins can not be made because one copy of the gene in each cell is stopped from performing its duty. These mutations are heterozygous and can be nonsense, short duplications, or deletions. At this time, there is no clear reason as to why a reduced amount of the SALL4 protein causes the symptoms of Duane-radial ray syndrome and similar conditions.Duane-radial ray syndrome is inherited through autosomal dominance meaning that a mutation in one copy of the SALL 4 gene is all it takes to cause this syndrome.
Imaging
MRI imaging can be used to detect whether the abducens nerve is present. Treatment
Typically, treatment for this condition requires a team of specialists and surgery. Below are the treatments based on the symptom. Duane Anomaly
Surgery for correction of severe strabismus

Radial Ray Malformations
Surgery for correction of severe malformations of the forearms
Construction of a functional thumb via surgery if aplasia of the thumb is present

Heart defects
If a congenital heart defect is present, cardiac surgery may be necessary
If a severe heart block is present, a pacemaker may have to be implanted
Antiarrhythmic medications and surgery as necessitated by a cardiologist

Hearing deficits
Hearing aids

Growth Retardation
Growth hormone therapy

Recent Research
There is currently recruitment for a clinical trial at Bostons Children Hospital. References
External links

Duane-radial ray syndrome at NLM Genetics Home Reference