Solifenacin, sold as the brand name Vesicare among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO). It may help with incontinence, urinary frequency, and urinary urgency. Benefits appear similar to other medications in the class. It is taken by mouth.Common side effects include dry mouth, constipation, and urinary tract infection. Severe side effects may include urinary retention, QT prolongation, hallucinations, glaucoma, and anaphylaxis. It is unclear if use is safe during pregnancy. It is of the antimuscarinic class and works by decreasing bladder contractions.Solifenacin was approved for medical use in the United States in 2004. In 2017, it was the 283rd most commonly prescribed medication in the United States, with more than one million prescriptions. Medical use
It is used to treat overactive bladder. It may help with incontinence, urinary frequency, and urinary urgency.Benefits appear similar to other antimuscarinics such as oxybutynin, tolterodine, and darifenacin.It is also used to treat neurogenic detrusor overactivity (NDO), a form of bladder dysfunction related to neurological impairment, in children ages two years and older. NDO is a dysfunction of the bladder that results from disease or injury in the nervous system. NDO may be related to congenital conditions (often-inherited conditions beginning at or before birth), such as spina bifida (myelomeningocele), or other conditions such as spinal cord injury. With NDO, there is overactivity of the bladder wall muscle, which normally relaxes to allow storage of urine.
Cost
A 2006 cost-effectiveness study found that 5 mg solifenacin had the lowest cost and highest effectiveness among anticholinergic drugs used to treat overactive bladder in the United States, with an average medical cost per successfully treated patient of $6863 per year. By 2019, with the introduction of generics, the retail cost of a months supply was down to $20 in the US. References
External links
"Solifenacin". Drug Information Portal. U.S. National Library of Medicine. "Solifenacin succinate". Drug Information Portal. U.S. National Library of Medicine.