), and move to the proboscis and into the saliva in its third larval stage (J3.). Maturation takes about seven days. The black fly takes another blood meal, passing the larvae into the next human hosts blood. The larvae migrate to the subcutaneous tissue and undergo two more molts. They form nodules as they mature into adult worms over six to 12 months. After maturing, adult male worms mate with female worms in the subcutaneous tissue to produce between 700 and 1,500 microfilaria per day. The microfilaria migrate to the skin during the day, and the black flies only feed in the day, so the parasite is in a prime position for the female fly to ingest it. Black flies take blood meals to ingest these microfilaria to restart the cycle. Diagnosis
Diagnosis can be made by skin biopsy (with or without PCR) or antibody testing. Classification
Onchocerciasis causes different kinds of skin changes, which vary in different geographic regions; it may be divided into the following phases or types:: 440–441 
Erisipela de la costa
An acute phase, it is characterized by swelling of the face, with erythema and itching. : 440  This skin change, erisípela de la costa, of acute onchocerciasis is most commonly seen among victims in Central and South America.Mal morando
This cutaneous condition is characterized by inflammation accompanied by hyperpigmentation. : 440 
Sowda
A cutaneous condition, it is a localized type of onchocerciasis.
Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial infections such as impetigo, impetigo contagiosa, ecthyma, folliculitis, Bockharts impetigo, furuncle, carbuncle, tropical ulcer, etc. Autoimmune conditions include pyoderma gangrenosum. Pyoderma affects more than 111 million children worldwide, making it one of the three most common skin disorders in children along with scabies and tinea. See also
List of cutaneous conditions

References


== External links ==