Erdafitinib, sold under the brand name Balversa, is an anti-cancer medication. It is a small molecule inhibitor of fibroblast growth factor receptor (FGFR) used for the treatment of cancer. FGFRs are a subset of tyrosine kinases which are unregulated in some tumors and influence tumor cell differentiation, proliferation, angiogenesis, and cell survival. Astex Pharmaceuticals discovered the drug and licensed it to Janssen Pharmaceuticals for further development.Researchers have investigated erdafitinib for safety and efficacy in treatment of bile duct cancer, gastric cancer, non-small cell lung cancer, and esophageal cancer.In March 2018, erdafitinib was granted breakthrough therapy designation by the U.S. Food and Drug Administration (FDA) for treatment of urothelial cancer.In April 2019, erdafitinib was granted approval by the FDA for treatment of metastatic or locally advanced bladder cancer with an FGFR3 or FGFR2 alteration that has progressed beyond traditional platinum-based therapies, subject to a confirmatory trial. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. Side effects
Common side effects include increased phosphate level, mouth sores, feeling tired, change in kidney function, diarrhea, dry mouth, nails separating from the bed or poor formation of the nail, change in liver function, low salt (sodium) levels, decreased appetite, change in sense of taste, low red blood cells (anemia), dry skin, dry eyes and hair loss.
Unlike other extraction techniques based on solubility of a compound in either water or oil, distillation will separate components regardless of their solubility. The distillate will contain compounds that vaporize at or below the temperature of distillation. The actual chemical components of these orange herbal distillates have not yet been fully identified, but plant distillates will usually contain essential oil compounds as well as organic acids and other water-soluble plant components. Compounds with a higher vaporization point will remain behind and will include many of the water-soluble plant pigments and flavonoids.Because hydrosols are produced at high temperatures and are somewhat acidic, they tend to inhibit bacterial growth but not fungal growth. They are not sterile, and should be kept refrigerated to preserve freshness. Herbal distillates degrade over time and will degrade faster than essential oils, which are more stable and will degrade slower. Small-scale producers of hydrosols must be particularly aware of the risk of bacterial contamination and take steps to prevent it. Despite concerns that there may be significant amounts of heavy metals in popular herbal distillates, this has not shown to be the case. See also
Orange flower water
Rose water
Witch hazel (astringent)

References
Books
Firth, Grace. Secrets of the Still. Epm Pubns Inc; First edition (June 1983)
Price, Len and Price, Shirley. Understanding Hydrolats: The Specific Hydrosols for Aromatherapy: A Guide for Health Professional. Churchill Livingstone 2004
Rose, Jeanne. 375 Essential Oils & Hydrosols. Frog, Ltd, Berkeley, CA, 1999. ISBN 1-883319-89-7
Rose, Jeanne. Hydrosols & Aromatic Waters. Institute of Aromatic & Herbal Study, 2007.