These include: 

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; fast or slow heartbeat; nausea; new or worsening chest pain; vomiting. Impaired biotransformation of ISDN to its active principle NO (or a NO-related species)
Neurohormonal activation, causing sympathetic activation and release of vasoconstrictors such as endothelin and angiotensin II which counteract the vasodilation induced by ISDN
Plasma volume expansion
The oxidative stress hypothesis (proposed by Munzel et al. in 1995)The last hypothesis might represent a unifying hypothesis, and an ISDN-induced inappropriate production of oxygen free radicals might induce a number of abnormalities which include the ones described above. Furthermore, nitrate tolerance is shown to be associated with vascular abnormalities which have the potential to worsen patients prognosis: these include endothelial and autonomic dysfunction. In the short run, ISDN can cause severe headaches, necessitating analgesic (very rarely up to morphine)  administration for relief of pain, as well as severe hypotension, and, in certain cases, bradycardia. This makes some physicians nervous and should prompt caution when starting nitrate administration. Mechanism of action
Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3,5-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber.
Methyl cellulose is also an important emulsifier, preventing the separation of two mixed liquids because it is an emulsion stabilizer. Food
The E number of methyl cellulose as food additive is E461. E464 is hydroxypropylcellulose and more soluble in water.Methyl cellulose, as a gel, has the unique property of setting when hot and melting when cold.Methyl cellulose is used as an ingredient in some meat analogues that are intended to replicate the texture of meat. Lubricant
Methyl cellulose may be used in personal lubricant. Construction materials
Methyl cellulose finds a major application as a performance additive in construction materials. It is added to mortar dry mixes to improve the mortars properties such as workability, open and adjustment time, water retention, viscosity, adhesion to surfaces etc. Construction grade methyl cellulose is not to be identified with food and pharmaceutical grade methyl cellulose and hydroxypropyl methyl cellulose, as it may be cross-linked with glyoxal for easy dispersion in water. The construction materials can be cement-based or gypsum-based. Notable examples of dry mixture mortars which utilize methyl cellulose include tile adhesives, EIFS, insulating plasters, hand-trowelled and machine-sprayed plaster, stucco, self-leveling flooring, extruded cement panels, skim coats, joint & crack fillers, and tile grouts. Typical usage is about 0.2% – 0.5% of total dry powder weight for dry mixtures. Derivatives of methyl cellulose which improve performance characteristics include hydroxypropyl methyl cellulose (HPMC) and hydroxyethyl methyl cellulose (HEMC). These derivatives typically improve the characteristics such as water retention, vertical surface slip resistance, open time, etc.