Enamel-renal syndrome is a rare autosomal recessive condition. This condition is also known as idiopathic multicentric osteolysis with nephropathy. It is characterised by dental abnormalities and nephrocalcinosis. Presentation
The dental abnormalities include

hypoplastic amelogenesis imperfecta
microdontia
intra-pulpal calcification
impacted posterior teeth with hyperplastic pericoronal follicles
gingival fibromatosis
ectopic calcifications on gingival and pericoronal tissues

Genetics
This condition is caused by mutations in the FAM20A gene. This gene encodes a protein – the Golgi apparatus associated secretory pathway pseudokinase. The gene is located on the long arm of chromosome 17 (17q24.2). Pathogensis
The protein is an allosteric activator of the Golgi serine/threonine protein kinase and is involved in biomineralization of teeth. Diagnosis
The diagnosis may be suspected on the basis of the constellation of clinical features. It is made by sequencing the FAM20A gene. This condition is usually diagnosed in childhood but may not be recognised until early adulthood. The diagnosis is suspected on the combination of nephrocalcinosis and dental abnormalities. Differential diagnosis
Epidermolysis bullosa
Jalili syndrome
Raine syndrome
Tricho-dento-osseous syndrome

Treatment
There is no specific treatment for this condition currently known and management of its various features is the norm. History
This condition was first described in 1972. == References ==
She was first treated for a bacteria-associated folliculitis, to which she had some symptom relief. However, the continuation of the pruritic folliculitis still persisted. She was later diagnosised with pruritic folliculitis of pregnancy after a histopathologic test was done to confirm sterility and immune cells. She then started "narrowband ultraviolet (UV) B phototherapy at 70% of the minimal erythemal dose with 20% increments using a three times per week treatment schedule" at 11 weeks of her pregnancy. With this treatment, her skin greatly improved after 10 treatments and completely resolved after 20 treatments. She did not have pruritic folliculitis for the remainder of her pregnancy.Treatment, whether it is pharmacological or non-pharmacological, can vary in pregnant individuals with pruritic folliculitis. The patients choice to accept such treatment can vary as well. There have been case reports on resolution of pruritic folliculitis in patients who declined and accepted treatment. There was a case report on a 39-year-old woman who experienced a 2-month long manifestation of pruritic folliculitis during the 27th week of pregnancy. The signs, symptoms, and histology of physical presentation were consistent with pruritic folliculitis. Although benzoyl peroxide was prescribed, the patient declined treatment. Without any treatment, her pruritic folliculitis condition resolved after giving birth. In another case report, a 26 year old woman who was 31 weeks into her pregnancy, reported that these inflamed pustules formed over her upper torso especially around her linea nigra and changed over the course of the last 2 months.