Four out of five cases occur on the legs, although historically the face was a more frequent site.Risk factors for developing the disease include
Arteriovenous fistula
Chronic skin conditions such as psoriasis, athletes foot, and eczema
Excising the saphenous vein
Immune deficiency or compromise, such as
Diabetes
Alcoholism
Obesity
Human immunodeficiency virus (HIV)
In newborns, exposure of the umbilical cord and vaccination site injury
Issues in lymph or blood circulation
Leg ulcers
Lymphatic edema
Lymphatic obstruction
Lymphoedema
Nasopharyngeal infection
Nephrotic syndrome
Pregnancy
Previous episode(s) of erysipelas
Toe web intertrigo
Traumatic wounds
Venous insufficiency or disease

Preventative measures
Individuals can take preventative steps to increase the chance they do not catch the disease. Properly cleaning and covering wounds is important for people battling an open wound. Effectively treating athletes foot or eczema if they were the cause for the initial infection will decrease the chance of the infection occurring again. People with diabetes should pay attention to maintaining good foot hygiene. It is also important to follow up with doctors to make sure the disease has not come back or spread. About one-third of people who have had erysipelas will be infected again within three years. Rigorous antibiotics may be needed in the case of recurrent bacterial skin infections. Notable cases
History
It was historically known as St. Anthonys fire. Citations


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Up to 12% of pentamidine is eliminated in the urine unchanged.Elimination: Pentamidine has an average half-life of 5–8 hours when given intravenously and 7–11 hours when given intramuscularly. However, these may increase with severe kidney problems. Pentamidine can remain in the system for as long as 8 months after the first injection. Chemistry
Pentamidine isethionate for injection is commercially available as a lyophilized, white crystalline powder for reconstitution with sterile water or 5% Dextrose. After reconstitution, the mixture should be free from discoloration and precipitation. Reconstitution with sodium chloride should be avoided due to formation of precipitates. Intravenous solutions of pentamidine can be mixed with intravenous HIV medications like zidovidine and intravenous heart medications like diltiazem. However, intravenous solutions of antiviral foscarnet and antifungal fluconazole are incompatible with pentamidine. To avoid side-effects associated with intravenous administration, the solution should be slowly infused to minimize the release of histamine. History
Pentamidine was first used to treat African trypanosomiasis in 1937 and leishmaniasis in 1940 before it was registered as pentamidine mesylate in 1950. Its efficacy against Pneumocystis jirovecii was demonstrated in 1987, following its re-emergence on the drug market in 1984 in the current isethionate form.