travel)Evaluation of past medical history includes:
Family history
Conditions such as inflammatory bowel disease, cystic fibrosis, and celiac diseasePhysical examination involves:
Abdominal examination (tenderness, distention, and/or bowel sounds)
Genital examination (rashes, anal fissures, and/or ulcerative lesions)
General assessment and vital signs (any signs of dehydration such as tachycardia and low blood pressure)
Examination of extremities and head (any signs of dehydration such as dry mucous membranes and skin turgor)

Diagnostic Tests
The following tests can also be performed to assist in the diagnosis of toddlers diarrhea and evaluation of any associated complications/underlying conditions:
Stool tests provide further information about bleeding, infectious agents, and/or anatomical problems. Blood tests allow assessment of inflammatory markers and/or other criterion for causative diseases. X-rays provide evaluations of any problems that may originate in the gastrointestinal tract/liver/etc. Upper endoscopy or colonoscopy allows visualization of the gastrointestinal tract to assess location of inflammation. Breath hydrogen tests are utilized to determine lactose, fructose, and/or sucrose intolerance. Small intestinal bacterial overgrowth (SIBO) may also be indicated by this test. Genetic Testing
Most commonly, chronic diarrhea in infants and children are classified as acquired diarrhea, identified with the general diagnostic tests mentioned above. The other classification of chronic diarrhea, congenital diarrheas and enteropathies (CODEs), are rare diagnoses of exclusion. With recent advances in genome sequencing, the addition of targeted genetic testing to diagnostic algorithms has been proposed to allow faster diagnoses and earlier treatment of CODEs. While certain genes and mutations have been associated with various CODEs, further research and studies are necessary to support the role of diagnostic genetic testing.
Canadian Family Physician issued a correction stating of previous articles which stated Diclectin should be used as a first line therapy where incorrect and were based upon undisclosed conflicts of interest with the manufacturer and where not peer reviewed studies:"Recommendations in 2 articles published in Canadian Family Physician, “Nausea and vomiting of pregnancy. Evidence-based treatment algorithm” and “Treatment of nausea and vomiting in pregnancy. An updated algorithm,” have subsequently come under critical scrutiny. These articles were not subjected to standard peer review, and Canadian Family Physician acknowledges that upon closer inspection these articles did not provide satisfactory evidence that would have justified the recommendation of doxylamine-pyridoxine as a sole first-line treatment for nausea and vomiting in pregnancy (NVP). More recent Canadian NVP guidelines have been published; however, a subsequent re-analysis questions the conclusions of 1 of the studies cited in these guidelines to justify doxylamine-pyridoxine as a recommended first-line treatment for NVP. Additionally, for the articles in Canadian Family Physician there was an undisclosed conflict of interest with Duchesnay, the manufacturer of Diclectin, the combination of doxylamine-pyridoxine. Canadian Family Physician encourages readers to interpret previously published NVP recommendations with caution. Readers are also referred to the commentary “Motherisk and Canadian Family Physician” in the January 2017 issue of Canadian Family Physician." [Ed: bolding to help summarize information, note please follow link to article to see the footnotes from this article]

Adverse effects
Pyridoxine, vitamin B6, is a water-soluble vitamin and is generally recognized as having no adverse effects.