1, 2, 3, 4, and 5), naproxen, indomethacin, diclofenac, and others, as well as more complex mixtures, including such mixtures as aspirin + paracetamol + codeine ± caffeine ± antihistamines and other agents, such as those mentioned above. Codeine-only products can be obtained with a prescription as a time release tablet. Codeine is also marketed in cough syrups with zero to a half-dozen other active ingredients, and a linctus (e.g., Paveral) for all of the uses for which codeine is indicated. Injectable codeine is available for subcutaneous or intramuscular injection only; intravenous injection is contraindicated, as this can result in nonimmune mast-cell degranulation and resulting anaphylactoid reaction. Codeine suppositories are also marketed in some countries. Side effects
Common adverse effects associated with the use of codeine include drowsiness and constipation. Less common are itching, nausea, vomiting, dry mouth, miosis, orthostatic hypotension, urinary retention, euphoria, and dysphoria. Rare adverse effects include anaphylaxis, seizure, acute pancreatitis, and respiratory depression. As with all opiates, long-term effects can vary, but can include diminished libido, apathy, and memory loss. Some people may have allergic reactions to codeine, such as the swelling of skin and rashes.Tolerance to many of the effects of codeine, including its therapeutic effects, develops with prolonged use. This occurs at different rates for different effects, with tolerance to the constipation-inducing effects developing particularly slowly for instance. A potentially serious adverse drug reaction, as with other opioids, is respiratory depression. This depression is dose-related and is a mechanism for the potentially fatal consequences of overdose.
Polyonychia also known as supernumerary nails is a condition in which two or more nails grow in the same finger or toe. Signs and symptoms
The signs/symptoms of polyonychia are very easy to detect: two or more nails growing on the same finger or toe. The nails can either be separate, small nails (micronychia) or one wide, almost complete nail, the digit affected could also be wider than normal

Causes
Polyonychia is generally caused by a congenital duplication of the distal phalange of the affected digit(s), this can be caused by congenital factors (sporadic without a genetic link) or by genetic factors (sporadic or familial with genetic link). It can also be caused by polysyndactyly, which is characterized as one normal digit being connected/webbed (syndactyly) to an extra digit (polydactyly). Polyonychia can also be acquired, such as after an accident that affected the nail bed causing it to split. This type of polyonychia is just referred to as "post-traumatic split nail" Polyonychias syndromic causes include:

Isolated congenital onychodysplasiaPolyonychias non-syndromic causes include:

Polyphalangism (more specifically of the distal phalange)
Polysyndactyly

See also
Polydactyly
Syndactyly
Polysyndactyly


== References ==