How the impacts on the different dimensions of food security play out and affect the food security of different population groups depends on where in the food supply chain the reduction in losses or waste takes place as well as on where nutritionally vulnerable and food-insecure people are located geographically.In April and May 2020, concerns were expressed that the COVID-19 pandemic could result in a doubling in global hunger unless world leaders acted to prevent this. Agencies such as the WFP have warned that this could include the number of people facing acute hunger rising from 135 million to about 265 million by the end of 2020. Indications of extreme hunger have been seen in various cities, such as fatal stampedes when word spread that emergency food aid was being handed out. Letters calling for co-ordinated action to offset the effects of the COVID-19 pandemic have been written to the G20 and G7, by various actors including NGOs, UN staff, corporations, academics and former national leaders. Following the 2022 invasion of Ukraine, concerns have been raised over hunger resulting from rising food prices. This is forecast to risk civil unrest even in many middle income countries, where government capability to protect their populations was largely exhausted by the Covid pandemic, and has not yet recovered. Hunger relief organisations
Many thousands of hunger relief organisations exist across the world. Some but not all are entirely dedicated to fighting hunger. They range from independent soup kitchens that serve only one locality,  to global organisations.
The activity of this enzyme is reduced by 50 percent in most people with variegate porphyria. In severe cases that begin early in life, the enzyme is almost completely inactive. Nongenetic factors such as certain drugs, stress, and others listed above can increase the demand for heme and the enzymes required to make heme. The combination of this increased demand and reduced activity of protoporphyrinogen oxidase disrupts heme production and allows byproducts of the process to accumulate in the liver, triggering an acute attack.Variegate porphyria is inherited in an autosomal dominant pattern, which means the defective gene is located on an autosome, and inheriting one copy of the defective gene from an affected parent is sufficient to cause the disorder. More severe cases result from inheriting two copies of the defective gene.The entire PPOX gene has about 8kb with 13 exon sequences. It was successfully cloned from a cDNA library in 1995 revealing that, after processing, it is 477 nucleotides long. It has previously been thought that the PPOX gene was located on human chromosome 14, however mapping experiments (FISH) have shown that it is near 1q23. An additional aggravating mutation affecting  variegate porphyria can be found at 6p21.3 on the HFE gene.A 2006 clinical, biochemical and mutational study of eight Swiss variegate porphyria patients and their families found four novel PPOX gene mutations believed to be unique to the Swiss population. Diagnosis
Diagnosis is by finding raised urine porphyrins, raised faecal porphyrins, markedly raised plasma porphyrins (pathognomic) and finding photosensitive cutaneous lesions on clinical examination.