Epidemiology
There are only about 14 reported cases of Morvans syndrome in the English literature. With only a limited number of reported cases, the complete spectrum of the central nervous system (CNS) symptomatology has not been well established. The natural history of Morvans is highly variable. Two cases have been reported to remit spontaneously. Others have required a combination of plasmapheresis and long term immunosuppression, although in one of these cases the patient died shortly after receiving plasma exchange (PE). Other fatalities without remission have been described by, amongst others, Morvan himself. References


== External links ==
Chemistry
Vitamin K is a fat-soluble vitamin that is stable in air and moisture but decomposes in sunlight. It is a polycyclic aromatic ketone, based on 2-methyl-1,4-naphthoquinone, with a 3-phytyl substituent. It is found naturally in a wide variety of green plants, particularly in leaves, since it functions as an electron acceptor during photosynthesis, forming part of the electron transport chain of photosystem I. Biological function
The best-known function of vitamin K in animals is as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX, and X by the liver. It is also required for the formation of anticoagulant factors protein C and S. It is commonly used to treat warfarin toxicity, and as an antidote for coumatetralyl. Vitamin K is required for bone protein formation. Biosynthesis
Vitamin K1 is synthesized from chorismate, a compound produced from shikimate via the shikimate pathway. The conversion of chorismate to vitamin K1 comprises a series of nine steps:
Chorismate is isomerized to isochorismate by isochorismate synthase, or MenF (menaquinone enzyme). Addition of 2-oxoglutarate to isochorismate by PHYLLO, a multifunctional protein comprising three different enzymatic activities         (MenD, H, and C). Elimination of pyruvate by PHYLLO. Aromatization to yield o-succinyl benzoate by PHYLLO. O-succinylbenzoate activation to corresponding CoA ester by MenE. Naphthoate ring formation by naphthoate synthase (MenB/NS). Thiolytic release of CoA by a thioesterase (MenH). Attachment of phytol chain to the naphthoate ring (MenA/ABC4). Methylation of the precursor at position 3 (MenG).