Such failure is called biochemical failure and is defined as a PSA reading of 2.0 ng/mL above nadir (the lowest reading taken post primary treatment).As of August 2014, a clinical trial administering sipuleucel-T in conjunction with ipilimumab (Yervoy) was tracking subjects but no longer enrolling new subjects; the trial evaluates the clinical safety and anti-cancer effects (quantified in PSA, radiographic and T cell response) of the combination therapy in patients with advanced prostate cancer. References
This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute. Further reading
Huber ML, Haynes L, Parker C, Iversen P (February 2012). "Interdisciplinary critique of sipuleucel-T as immunotherapy in castration-resistant prostate cancer". Journal of the National Cancer Institute. 104 (4): 273–9. doi:10.1093/jnci/djr514. PMC 3283534. PMID 22232132. "Sipuleucel-T: APC 8015, APC-8015, prostate cancer vaccine--Dendreon". Drugs in R&D. 7 (3): 197–201. 2006. doi:10.2165/00126839-200607030-00006. PMID 16752945. External links
"Sipuleucel-T". Drug Information Portal. U.S. National Library of Medicine.
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Punctate porokeratosis is a skin condition associated with either classic porokeratosis or linear porokeratosis types of porokeratosis, and is characterized by multiple, minute, and discrete punctate, hyperkeratotic, seed-like skin lesions surrounded by a thin, raised margin on the palms and soles. : 535 : 1668 
Porokeratosis plantaris discreta is a skin condition that occurs in adults, with a 4:1 female preponderance, characterized by a sharply marginated, rubbery, wide-based papules. : 213   It is also known as "Steinbergs lesion". It was characterized in 1970. Genetics
Linear porokeratosis has been associated with mutations in the PMVK and MVD genes. The PMVK gene encodes the enzyme phosphomevalonate kinase and the MVD gene encodes the enzyme diphosphomevalonate decarboxylase. Diagnosis
Pathology
Porokeratosis has a characteristic histomorphologic feature known as a cornoid lamella. Treatment
Dermabrasion

See also
List of cutaneous conditions
List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer

References
External links

Database of rare diseases at Orphanet
NIHs Genetic and Rare Diseases Information Center