Conversely, they are thought to produce reward and addiction via activation of the MOR in the mesolimbic reward pathway, including in the ventral tegmental area, nucleus accumbens, and ventral pallidum. Tolerance to the analgesic and rewarding effects of opioids is complex and occurs due to receptor-level tolerance (e.g., MOR downregulation), cellular-level tolerance (e.g., cAMP upregulation), and system-level tolerance (e.g., neural adaptation due to induction of ΔFosB expression).Taken orally, 20 mg of immediate-release oxycodone is considered to be equivalent in analgesic effect to 30 mg of morphine, while extended release oxycodone is considered to be twice as potent as oral morphine.Similarly to most other opioids, oxycodone increases prolactin secretion, but its influence on testosterone levels is unknown. Unlike morphine, oxycodone lacks immunosuppressive activity (measured by natural killer cell activity and interleukin 2 production in vitro); the clinical relevance of this has not been clarified. Active metabolites
A few of the metabolites of oxycodone have also been found to be active as MOR agonists, some of which notably have much higher affinity for (as well as higher efficacy at) the MOR in comparison. Oxymorphone possesses 3- to 5-fold higher affinity for the MOR than does oxycodone, while noroxycodone and noroxymorphone possess one-third of and 3-fold higher affinity for the MOR, respectively, and MOR activation is 5- to 10-fold less with noroxycodone but 2-fold higher with noroxymorphone relative to oxycodone. Noroxycodone, noroxymorphone, and oxymorphone also have longer biological half-lives than oxycodone.
Differences in gendered-morality, and female hostility toward societal ideals
The author of The Fear of Women, Wolfgang Lederer, makes the argument in his book that gynophobia is partially the result of men and women allegedly having different attitudes toward societally-based morality. He argues that women were mostly absent and also sometimes explicitly excluded from the meaningful aspects of the creation of society. He further argues that this contributes to what he sees as historically-universal female hostility toward societal goals such as justice, goals which exist outside practical and immediate interpersonal affairs. Wolfgang argues that this is not just his idea, but projected into religion through all historical communities that have both a father-deity and a mother-deity, where, he argues, the mother-deity is always morally indifferent. Because Wolfgang thinks that men generally have societal ideals, while women generally do not, Wolfgang argues that real women intrude obstinately and necessarily on an imagined ideal of women that men have of them. He states that this births a male fear that women will forever, or sooner or later, be his disappointment. Basic resource access barriers and population expansion limitations
Extreme examples of universal, cultural gypnohobia have been found in the highlands of New Guinea, where widespread anti-masturbation propaganda coincides with notions of, "perilous female sexuality". The anthropologist Carol Ember argues that such fears were likely caused by limited availability of basic resources that would be required to increase the population. See also

List of phobias


== References ==