As such, it appears that similarly to depot medroxyprogesterone acetate, combined injectable contraceptives with 5 mg estradiol cypionate and 25 mg medroxyprogesterone acetate have less or no procoagulant effect relative to combined birth control pills. Pharmacokinetics
Intramuscular injection
In contrast to oral administration, which is associated with very low bioavailability (<10%), the bioavailability of both estradiol and estradiol esters like estradiol valerate is complete (i.e., 100%) via intramuscular injection. In addition, estradiol esters like estradiol cypionate and estradiol valerate when given as an injection of oil solution or microcrystalline aqueous suspension have a relatively long duration due to the formation of an intramuscular depot from which they are slowly released and absorbed. Upon intramuscular injection of estradiol cypionate in an oil solution, the solvent (i.e., oil) is absorbed, and a primary microcrystalline depot is formed within the muscle at the site of injection. In addition, a secondary depot may be formed in adipose tissue. The slow release of estradiol cypionate from the tissue depot is caused by the high lipophilicity of the estradiol ester, which in turn is due to its long fatty acid cypionic acid ester moiety. Estradiol cypionate is formulated for use alone and in combination with testosterone cypionate as an oil solution, and for use in combination with medroxyprogesterone acetate as a microcrystalline aqueous suspension.
Seal finger, also known as sealers finger and spekkfinger (from the Norwegian for "blubber"), is an infection that afflicts the fingers of seal hunters and other people who handle seals, as a result of bites or contact with exposed seal bones; it has also been contracted by exposure to untreated seal pelts. The State of Alaska Section of Epidemiology defines it as "a finger infection associated with bites, cuts, or scratches contaminated by the mouths, blood, or blubber of certain marine mammals".It can cause cellulitis, joint inflammation, and swelling of the bone marrow; untreated, the course of "seal finger" is slow and results often in thickened contracted joint. Historically, seal finger was treated by amputation of the affected digits once they became unusable. It was first described scientifically in 1907.The precise nature of the organism responsible for seal finger is unknown, as it has resisted culturing because most cases are promptly treated with antibiotics; however, as seal finger can be treated with tetracycline or similar antibiotics, the causative organism is most likely bacterial, or possibly fungal; in 1998, Baker, Ruoff, and Madoff showed that the organism is most likely a species of Mycoplasma called Mycoplasma phocacerebrale. This Mycoplasma was isolated in an epidemic of seal disease occurring in the Baltic Sea. Notes
External links
Working with Marine Mammals and Your Health, NOAA brochure on zoonoses, including seal finger. (requires Acrobat Reader (via archive.org))