Erectile dysfunction and hypogonadism, resulting in decreased libido, amenorrhea
Congestive heart failure, abnormal heart rhythms, or pericarditis
Arthritis of the hands (especially the second and third metacarpophalangeal joints), but also the knee and shoulder joints
Weight lossLess common findings including:

Memory loss
Hair loss
Splenomegaly
adrenal insufficiency
Deafness
Dyskinesias, including Parkinsonian symptoms
Dysfunction of certain endocrine organs:
Parathyroid gland (leading to hypocalcaemia)
Pituitary gland: secondary hypothyroidism, secondary hypogonadism
Adrenal gland
An increased susceptibility to certain infectious diseases caused by siderophilic microorganisms:
Vibrio vulnificus infections from eating seafood or wound infection
Listeria monocytogenes
Yersinia enterocolica
Salmonella enterica (serotype Typhymurium)
Klebsiella pneumoniae
Escherichia coli
Rhizopus arrhizus
Mucor species
Aspergillus fumigatus
Cytomegalovirus
Hepatitis B virus
Hepatitis C virusIn the hereditary hemochromatosis (HH or HHC), males are usually diagnosed after their forties and fifties, and women some decades later, during menopause. The severity of clinical disease varies considerably. Some evidence suggests that hereditary haemochromatosis patients affected with other liver ailments such as hepatitis or alcoholic liver disease have worse liver disease than those with either condition alone. Also, juvenile form of primary haemochromatosis (Hemochromatosis type 2) present in childhood with the same consequences of iron overload. End-organ damage
Iron is stored in the liver, pancreas and heart. Long-term effects of haemochromatosis on these organs can be serious, even fatal when untreated.Since the liver is a primary storage area for iron and naturally accumulates excess iron over time, it is likely to be damaged by iron overload. Toxins may accumulate in the blood and eventually affect mental functioning due to increased risk of hepatic encephalopathy. Together, they can increase the risk of liver cancer to one in three persons.
However, a phobia is an irrational fear as opposed to a rational fear.By ensuring that their surroundings were free from spiders, arachnophobes would have had a reduced risk of being bitten in ancestral environments, giving them a slight advantage over non-arachnophobes in terms of survival. However, having a disproportionate fear of spiders in comparison to other, potentially dangerous creatures present during Homo sapiens environment of evolutionary adaptiveness may have had drawbacks.In The Handbook of the Emotions (1993), psychologist Arne Öhman studied pairing an unconditioned stimulus with evolutionarily-relevant fear-response neutral stimuli (snakes and spiders) versus evolutionarily-irrelevant fear-response neutral stimuli (mushrooms, flowers, physical representation of polyhedra, firearms, and electrical outlets) on human subjects and found that ophidiophobia (fear of snakes) and arachnophobia required only one pairing to develop a conditioned response while mycophobia, anthophobia, phobias of physical representations of polyhedra, firearms, and electrical outlets required multiple pairings and went extinct without continued conditioning while the conditioned ophidiophobia and arachnophobia were permanent.Psychiatrist Randolph M. Nesse notes that while conditioned fear responses to evolutionarily novel dangerous objects such as electrical outlets is possible, the conditioning is slower because such cues have no prewired connection to fear, noting further that despite the emphasis of the risks of speeding and drunk driving in drivers education, it alone does not provide reliable protection against traffic collisions and that nearly one-quarter of all deaths in 2014 of people aged 15 to 24 in the United States were in traffic collisions.