Its diagnoses must meet all four of the following criteria: biopsy-proven tumor consisting of clonal plasma cells; no evidence of any other plasmacytomas based on bone survey and MRI (or in place of MRI, CT scan); normal bone marrow examination; and absence end organ damage, CRAB features, or other signs or symptoms of systemic disease attributable to a plasma cell dyscrasia. Blood or urine myeloma proteins are usually undetectable or low in solitary plasmacytomas. Solitary plasmacytoma is a rare disease with an incidence in the USA of <450 cases per year. In a review of 1,691 cases in the US, the median age at diagnosis was 63 with males representing ~60% of all cases. The most common site of plasmacytoma involvement was bone (~58%) followed by upper or lower airway tract (~16%), soft tissue or connective tissue (~5%), central nervous system (~3%), gastrointestinal tract (~3%), skin (~1%), and all other sites (~3%). Overall median survival was 8.12 years with survival decreasing with age from 12.4 years for patients <40 to 5.2 years for patients of 60 years or older. Risk of its recurrence or progression to overt multiple myeloma within 3 years is ~10%.A subset of solitary plasmacytomas, termed solitary plasmacytoma with minimal bone marrow involvement, has the same criteria for diagnosis as solitary plasmacytoma except that bone marrow examination shows an increase in plasma cells from a normal value of ~0% to 1.5% to >~1.6% but less than 10% of total nucleated cells.
Lipoblastoma is a type of rare, subcutaneous, benign, fatty tumor, found in infants, and children, more common in males with tendency of local recurrence. Local recurrence can happen in up to 80% of incompletely resected tumours. Therefore, complete surgical resection is required to prevent recurrence. It arises from embyronic white fat that is rapidly enlarging. Most common locations are at the trunk and extremities.Types include:
Benign lipoblastomatosis, a tumor, also known as an embryonic lipoma, which usually occurs in children under three years old. This is the tumor of brown fat cells. Myxoid lipoblastoma, a cutaneous condition characterized by excess mucin

Specimen
Macroscopic
Grossly, it has a pale yellow, myxoid cut surface with small cystic foci. Microscopic
It has lobules consists of immature adipose tissue separated by fibrous septa and lipoblasts at different stages of maturation, without atypia or mitosis. Plexiform capillary network and mature adipose tissue are seen at the central part of the lobule. See also
Lipoblast
Lipoma


== References ==