Aromatase excess syndrome (AES or AEXS) is a rare genetic and endocrine syndrome which is characterized by an overexpression of aromatase, the enzyme responsible for the biosynthesis of the estrogen sex hormones from the androgens, in turn resulting in excessive levels of circulating estrogens and, accordingly, symptoms of hyperestrogenism. It affects both sexes, manifesting itself in males as marked or complete phenotypical feminization (with the exception of the genitalia; i.e., no pseudohermaphroditism) and in females as hyperfeminization.To date, 30 males and 8 females with AEXS among 15 and 7 families, respectively, have been described in the medical literature. Signs and symptoms
Observed physiological abnormalities of the condition include a dramatic overexpression of aromatase and, accordingly, excessive levels of estrogens including estrone and estradiol and a very high rate of peripheral conversion of androgens to estrogens. In one study, cellular aromatase mRNA expression was found to be at least 10 times higher in a female patient compared to the control, and the estradiol/testosterone ratio after an injection of testosterone in a male patient was found to be 100 times greater than the control.
Should signs of pulmonary edema occur when inhaled iloprost is administered in patients with pulmonary hypertension, the treatment should be stopped immediately. This may be a sign of pulmonary venous hypertension. See also
Pulmonary arterial hypertension (PAH)
Raynauds phenomenon
Scleroderma

References
Ventavis Package insert prescribing information available in PDF format. Olschewski, Horst; Simonneau, Gerald; Galiè, Nazzareno; Higenbottam, Timothy; Naeije, Robert; Rubin, Lewis J.; Nikkho, Sylvia; Speich, Rudolf; Hoeper, Marius M.; Behr, Jürgen; Winkler, Jörg; Sitbon, Olivier; Popov, Wladimir; Ghofrani, H. Ardeschir; Manes, Alessandra; Kiely, David G.; Ewert, Ralph; Meyer, Andreas; Corris, Paul A.; Delcroix, Marion; Gomez-Sanchez, Miguel; Siedentop, Harald; Seeger, Werner (August 1, 2002). "Inhaled Iloprost for Severe Pulmonary Hypertension". New England Journal of Medicine. 347 (5): 322–329. doi:10.1056/NEJMoa020204. PMID 12151469. ATS 2005. The International Conference of the American Thoracic Society. 20–25 May 2005. San Diego, CA. Meizer, Roland; Meraner, Dominik; Meizer, Elisbeth; Radda, Christian; Landsiedl, Franz; Aigner, Nicolas (Jan 2009). "Outcome of painful bone marrow edema of the femoral head following treatment with parenteral iloprost". Indian Journal of Orthopaedics. 43 (1): 36–9. doi:10.4103/0019-5413.45321. PMC 2739485. PMID 19753177. External links
"Iloprost". Drug Information Portal. U.S. National Library of Medicine.