While this theory would fit the fact that molsidomine (which is not reduced) does not exhibit tachyphylaxis, it has meanwhile been refuted. Newer theories include increase of oxidative stress resulting in deactivation of NO to peroxynitrite, and liberation of the vasoconstrictors angiotensin II and endothelin as the blood vessels reaction to NO-mediated vasodilation. Differences in pharmacokinetics
Nitrates mainly differ in speed and duration of their action. Glyceryl trinitrate acts fast and short (10 to 30 minutes), while most other nitrates have a slower onset of action, but are effective for up to six hours. Molsidomine, as has been mentioned, not only acts slowly but also differs from the nitrates in exhibiting no tolerance. Nitroprusside, given intravenously, acts immediately, and after stopping the infusion blood pressure returns to its previous level within ten minutes. See also
History of glyceryl trinitrate
Biological functions of nitric oxide


== References ==
A lobulation is an appearance resembling lobules. For instance, the thyroid gland may become large and lobulated in Hashimotos thyroiditis.Fetal lobulation, also known as fetal lobation, of the kidney is evident on scanning. Fetal lobation is a normal stage in the development of the kidney. In the adult a normal anatomic variant is that of persistent fetal lobulation of the kidney that may be mistaken for a tumour. See also
Lobation


== References ==