Odontogenic keratocysts do not result in the same degree of bony expansion as dentigerous cysts and teeth resorption are less likely to be seen in association with odontogenic keratocysts. In addition, dentigerous cysts are more likely to have smooth periphery and odontogenic keratocysts are more likely to display a scalloped periphery. Unicystic ameloblastomaIt is the most common radiolucent, benign odontogenic tumor that may be unilocular or multilocular. It may result in expansion and destruction of the maxilla and mandible. It is not possible to differentiate unicystic ameloblastomas from dentigerous cysts with clinical and radiographic examinations. Histopathologic examination revealed that the basilar cells in unicystic ameloblastoma become columnar and demonstrate prominent nuclear hyperchromatism. The polarization of nuclei may be away from the basement membrane (reverse polarization). Besides, the superficial epithelial layers may become loosely arranged and resemble the stellate reticulum of the enamel organ. Pindborg tumorIt is a rare odontogenic tumor that is radiolucent with well-defined border and associated calcified radiopaque foci. Adenomatoid odontogenic tumorAdenomatoid odontogenic tumor also shows similar features as dentigerous cyst; however, the  differentiation is by the presence of intra-cystic radio-opaque structures. In younger patients, the periapical radiolucencies associated with deciduous teeth may mimic pericoronal radiolucencies of succedaneous permanent teeth and may result in a false impression of dentigerous cyst. A definitive diagnosis will not be made based on radiographs alone. The diagnosis can only be confirmed by histopathological examination. OdontomaIt is a lytic lesion that is frequently accompanied by amorphous calcification.
Serology and protein-based methods
IFA (immunofluorescence antibody assay) testing for the presence of antibodies in serum is used to diagnose B. henselae infection at the acute onset of Cat Scratch Disease symptoms, followed by PCR to confirm infecting species. IFA can generally be used to confirm a diagnosis of Bartonella infection, but is limited by antibody cross-reactivity with other bacteria species  which can cause a false positive, and antigen variability which can result in false negatives.Bartonella spp. often evade an immune response, thus antibodies may not be detected even concurrent with an infection, resulting in an IFA false negative rate of up to 83% in chronically infected patients when other test results (e.g. organism isolation or PCR) are positive. IFA sensitivity may range from 14 to 100%, causing discrepancies between PCR and serology test results. Positive IFA results do not distinguish between current infection and prior exposure.ELISA (enzyme-linked immunosorbent assay) is another method that has been used to detect Bartonella, but it has a low sensitivity (17-35%). Western blot for protein detection of Bartonella-associated proteins has also been reported, but this method does not show clear immunoreactive profiles. PCR
The CDC states that PCR testing from a single blood draw is not sufficiently sensitive for B. henselae testing, and can result in high false negative rates  due to a small sample volume and levels below the limit of molecular detection.Bartonella spp.