The sodium salt of the acid is sodium valproate and a coordination complex of the two is known as valproate semisodium. Medical uses
It is used primarily to treat epilepsy and bipolar disorder. It is also used to prevent migraine headaches. Epilepsy
Valproate has a broad spectrum of anticonvulsant activity, although it is primarily used as a first-line treatment for tonic–clonic seizures, absence seizures and myoclonic seizures and as a second-line treatment for partial seizures and infantile spasms. It has also been successfully given intravenously to treat status epilepticus. Mental illness
Bipolar disorder
Valproate products are also used to treat manic or mixed episodes of bipolar disorder. Schizophrenia
A 2016 systematic review compared the efficacy of valproate as an add-on for people with schizophrenia:

Dopamine dysregulation syndrome
Based upon five case reports, valproic acid may have efficacy in controlling the symptoms of the dopamine dysregulation syndrome that arise from the treatment of Parkinsons disease with levodopa. Migraines
Valproate is also used to prevent migraine headaches. Other
The medication has been tested in the treatment of AIDS and cancer, owing to its histone-deacetylase-inhibiting effects. Contraindications
Contraindications include:

Pre-existing acute or chronic liver dysfunction or family history of severe liver inflammation (hepatitis), particularly medicine related.
A giant solitary trichoepithelioma is a cutaneous condition characterized by a skin lesion that may be up to several centimeters in diameter. : 672

See also
Trichoepithelioma
Skin lesion

References


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