In such patients with chronic kidney disease where a glycoprotein IIb/IIIa inhibitor is likely to provide benefit, Abciximab (trade name: Reopro) is an alternative medication. Current bleeding tendencies or abnormally prolonged coagulation parameters observed within 30 days before starting therapy with eptifibatide is intended. Coagulation parameters such as ACT, aPTT, TT, and PT should be followed closely during therapy and afterwards. Allergy to eptifibatide and/or other ingredients. Severe, uncontrolled hypertension. Pregnancy : No experience exists. Pregnant patients should be treated only when clearly needed. Lactation : No human data exists. Breast-feeding should be avoided during treatment in order to prevent damage to the newborn. Geriatric patients : No differences in side effects compared with younger patients have been seen. Nevertheless, geriatric patients should be very closely observed for bleeding and other side-effects. Pediatric patients : Eptifibatide is not indicated in patients below 18 years of age, because no experience exists. Side effects
People receiving eptifibatide are typically seriously ill and most of them are concomitantly treated with other drugs known to have the potential to cause significant side effects. Therefore, not all side effects listed as follows may be attributable to eptifibatide treatment alone:
The major adverse event in the PURSUIT study was severe bleeding. Bleeding occurred as well at sites of clinical intervention (local sites) as at other sites (systemically) like urogenital bleeds. Sometimes, these events were severe enough to require transfusion of blood or plasma concentrates to stop bleeding and counteract anemia.
Dorothy Squires
In the midst of Sinatras multiple runs on the UK Singles Chart, Welsh singer Dorothy Squires also released a rendition of "My Way" in Summer 1970. Her recording reached number 25 on the UK Singles Chart and re-entered the chart twice more during that year. Elvis Presley
Elvis Presley began performing the song in concert during the mid-1970s, despite Ankas suggestions that the song did not suit him. Nevertheless, on January 12 and 14, 1973, Presley sang the song during his satellite show Aloha from Hawaii Via Satellite, beamed live and on deferred basis (for European audiences, who also saw it in prime time), to 43 countries via Intelsat. On October 3, 1977, several weeks after Presleys death, his live recording of "My Way" (recorded for the Elvis In Concert CBS-TV special on June 21, 1977) was released as a single. In the U.S., it reached number 22 on the Billboard Hot 100 pop singles chart in late 1977/early 1978 (higher than Frank Sinatras peak position), number 6 on the Billboard Adult Contemporary chart, and went gold for its successful sales of over a million copies. The following year the single reached number 2 on the Billboard Country singles chart but went all the way to number 1 on the rival Cash Box Country Singles chart. In the UK, it reached number 9 on the UK Singles Chart. Presleys version is featured in the climax of the 2001 film 3000 Miles to Graceland with Kurt Russell and Kevin Costner.