Discrete subcutaneous neurofibromas: Lie below and look like bumps on the skin, which can sometimes be tender. Deep nodular neurofibromas: Involving tissues and organs underneath the dermis, but otherwise resembling cutaneous and subcutaneous neurofibromas. Age of onset
Dermal neurofibromas typically arise in the teenage years and are often associated with the onset of puberty. In people with Neurofibromatosis Type I,  they tend to continue to increase in number and size throughout adulthood, although limits exist as to how big they get, and cases progress at highly variable rates. Medical complications
Dermal neurofibromas can lead to stinging, itching, pain, and disfigurement. No evidence of malignant transformation has been found. Plexiform neurofibroma
Anatomy
Plexiform neurofibromas can grow from nerves in the skin or from more internal nerve bundles, and can be very large. Internal plexiform neurofibromas are very difficult to remove completely because they extend through multiple layers of tissue and the attempt would damage healthy tissue or organs. Age of onset
Plexiform neurofibromas occur earlier in life and are thought to be congenital defects. Medical complications
Plexiform neurofibroma can cause disfigurement, neurological, and other clinical deficits. Plexiform neurofibromas have the potential to cause severe clinical complications if they occur in certain areas.About 10% of plexiform neurofibromas undergo transformation into a malignant peripheral nerve sheath tumor. Plexiform neurofibroma is a known precursor for MPNST in NF1 patients. The formation of malignant cancers from neurofibromas is associated with the loss of expression of the CDKN2A or TP53 gene in nonmyelinating Schwann cells that also exhibit biallelic inactivation of the NF1 gene.
Megalocornea (MGCN, MGCN1) is an extremely rare nonprogressive condition in which the cornea has an enlarged diameter, reaching and exceeding 13 mm. It is thought to have two subforms, one with autosomal inheritance and the other X-linked (Xq21.3-q22). The X-linked form is more common and males generally constitute 90% of cases.It may be associated with Alport syndrome, craniosynostosis, dwarfism, Down syndrome, Parry–Romberg syndrome, Marfan syndrome, mucolipidosis, Frank–ter Haar syndrome, crouzon syndrome, megalocornea-mental retardation syndrome etc. Clinical features
Eyes are usually highly myopic. There may be with the rule astigmatism. Lens may be luxated due to zonular streaching.In rare cases, it might be associated with intellectual disabilities. References
External links

Megalocornea - eMedicine ophthalmology; May 15, 2009; Thomas A Oetting, MD, Mark A Hendrix, MD
An Infant With Enlarged Corneas - medscape