A clip of the ad can be seen briefly in the 1988 motion picture The In Crowd, immediately before the movies first live broadcast of the fictitious "Perry Parkers Dance Party." In an Alka-Seltzer commercial from 1969, an actor (played by Jack Somack) in a commercial for the fictional product "Magdalinis Meatballs" has to eat a meatball and then say "Mamma mia, thats-a spicy meat-a ball-a!" in an ersatz Italian accent. Take after take is ruined by some comedic trial or another (comedian Ronny Graham dropping the clapperboard). By the commercials end, Jack has eaten so many meatballs that its "Alka-Seltzer to the rescue." With his stomach settled, Jack does a perfect take, except that the oven door falls off. The director (off-camera) sighs and says, "OK, lets break for lunch. "A 1970 commercial shows a newlywed couple in the bedroom after the woman (played by Alice Playten) has finished serving her husband (played by Terry Kiser) a giant dumpling; the implication is that her cooking skills are severely lacking, despite her husbands lament, "I cant believe I ate that whole thing! ", the commercials catchphrase. She lies on the bed in delusional triumph. She offers her beleaguered husband a heart-shaped meatloaf; he disappears to take some Alka-Seltzer. When she hears the fizzy noise coming from the bathroom, he quickly covers the glass of dissolving Alka-Seltzer as she wonders aloud if it is raining.
In his 1976 revival Beals proclaimed Alka-Seltzers virtues and sang the "Plop, plop, fizz, fizz, oh what a relief it is" song in his iconic high, squeaky voice. In the early 1960s, a commercial showing two tablets dropping into a glass of water instead of the usual one caused sales to double.Alka-Seltzer TV ads from the 1960s and 1970s in the US were among the most popular of the 20th century, ranking number 13, according to Advertising Age. To increase sales in a relatively flat business, Bayer  revived several of the vintage spots.Paul Margulies (father of actress Julianna Margulies) created the famous "Plop, plop, fizz, fizz" ad campaign when he worked as a Madison Avenue ad executive. The ubiquitous jingle was composed by Tom Dawes—a former member of The Cyrkle. The slogan was altered to "Plink, plink, fizz" in the United Kingdom.During the race for space in the early 1960s before the moon landing, there was a commercial with Speedy in a space suit and a jingle with the lyrics "On Mans first trip through space, I only hope that Im aboard, securely strapped in place. Theyll track our ship with radar and telescopes and soon, imagine seeing Speedy Alka-Seltzer on the moon! "George Raft starred in the 1969 Alka-Seltzer commercial "The Unfinished Lunch". It consisted of Raft incarcerated in a prison lunchroom. He takes a bite of the prison food and recoils. Suddenly he bangs his cup on the steel table. It ripples throughout the room.