Pioneered in the laboratory of Edward D. Korn at the National Institutes of Health (NIH), many important biological molecules have been discovered and their pathways elucidated using the Acanthamoeba model. Thomas Dean Pollard applied this model at the NIH, Harvard Medical School, Johns Hopkins University School of Medicine, and the Salk Institute for Biological Studies to discover and characterize many proteins that are essential for cell motility, not only in amoebae, but also in many other eukaryotic cells, especially those of the human nervous and immune systems, the developing embryo, and cancer cells. Acanthamoeba also has served as a model to study the evolution of certain G-proteins. This unicellular eukaryote expresses few GPCRs over its cell membrane that serve vital role for the microorganism, structural homology bioinformatics tools have been used to show the presence of a homolog of human M1-muscarinic receptor in A. castellanii. Blocking these muscarinic receptors in past studies has proven to be amoebicidal in Acanthamoeba spp. More recently, voltage-gated calcium channels in Acanthamoeba spp. (CavAc) have been reported to have similarities with human voltage-gated calcium channels such as TPC-1 and L-type calcium channels and respond to Ca-channel blockers such as loperamide. This model microbe has been studied to understand complex neurodegenerative states including Alzheimers disease. Scientists have isolated a neurotransmitter acetylcholine in Acanthamoeba and the enzymatic machinery needed for its synthesis. Endosymbionts
Acanthamoeba spp. contain diverse bacterial endosymbionts that are similar to human pathogens, so they are considered to be potential emerging human pathogens.
The Riddoch syndrome is a term coined by Zeki and Ffytche (1998) in a paper published in Brain. The term acknowledges the work of George Riddoch who was the first to describe a condition in which a form of visual impairment, caused by lesions in the occipital lobe, leaves the sufferer blind but able to distinguish visual stimuli with specific characteristics when these appear in the patients blind field. The most common stimuli that can be perceived consciously are the presence and direction of fast moving objects (moving at a speed in excess of 10 degrees per second); in his work these moving objects were described as "vague and shadowy". Riddoch concluded from his observations that "movement may be recognized as a special visual perception".Riddochs description was dismissed by Sir Gordon Holmes in a 1918 paper in which he wrote that" The condition described by Riddoch should not be spoken of as a dissociation of the elements of visual sensation" because "occipital lesions do not produce true dissociations of function with intact retinal sensibility". The idea of a separate representation of visual motion was further dismissed by H.L. Teuber  and, in general, such an idea was not accepted until physiological studies in the monkey demonstrated the existence of a cortical area lying outside the primary visual cortex (area V1) in which almost all cells were selective for directional motion.