Paroxysms of laughter have no relation to the EEG, ruling out this feature as a gelastic phenomenon.EEG anomalies may be used as a quantitative biomarkers to "chart progression of AS and as clinical outcome measures". Slow delta activity (~3 Hz) is greatly increased in AS relative to typically developing children, yet more pronounced in children with partial 15q deletions as opposed to those with etiologies principally affecting UBE3A. Theta activity (~5 Hz) is much greater in children with partial 15q deletions. Thus, delta activity appears to be chiefly reflective of UBE3A dysfunction with some modulation from other 15q genes, whereas theta activity may be an electrophysiological readout of genes beyond UBE3A such as GABRA5, GABRB3, and GABRG3. Future clinical trials in AS might exploit the foregoing by using EEG as a readout of drug target engagement.It appears that the neurons of people with Angelman syndrome are formed correctly, but they cannot function properly. Diagnosis
The diagnosis of Angelman syndrome is based on:
A history of delayed motor milestones and then later a delay in general development, especially of speech
Unusual movements including fine tremors, jerky limb movements, hand flapping and a wide-based, stiff-legged gait. Characteristic facial appearance (but not in all cases). A history of epilepsy and an abnormal EEG tracing.
Complication or complications may refer to:

Dramatic arts
"Complications" (CSI: Miami), an episode of CSI: Miami
"Complications" (Terminator: The Sarah Connor Chronicles), an episode of Terminator: The Sarah Connor Chronicles
Complications (TV series), a 2015 USA Network television series starring Jason OMara

Medicine
Complication (medicine), an unfavorable evolution of a disease, health condition or  medical treatment

Music
Albums
Complications - Trilogy of Intricacy, a 2005 EP by Norwegian progressive metal band Age of Silence
Complications (Dover album), a 2015 album by Spanish rock band Dover

Songs
"Complication", a 1999 song by Nine Inch Nails from The Fragile
"Complications", a 2008 song by deadmau5 from Random Album Title

Technology
Complication (horology), a clock display other than the time
Smartwatch complication Complication (horology)#Use in smartwatches