Severe damage to the medial dorsal nucleus inevitably results in memory deficit. Additionally, autopsies of people who had KS have showed lesions in both the midline and anterior thalamus, and thalamic infarctions. Bilateral infarctions to the thalamus can result in Korsakoff-induced amnesia as well. These findings imply damage to anterior thalamic nuclei can result in disruptive memory. Risk factors
A number of factors may increase a persons risk to develop Korsakoff syndrome. These factors are often related to general health and diet. Age
Alcoholism
Chemotherapy
Dialysis
Extreme dieting
Genetic factors

Diagnosis
KS is primarily a clinical diagnosis; imaging and lab tests are not necessary. Prevention
The most effective method of preventing AKS is to avoid thiamine deficiency. In Western nations, the most common causes of such a deficiency are alcoholism and eating disorders. Because these are behavioral-induced causes, Korsakoff syndrome is essentially considered a preventable disease. Thus, fortifying foods with thiamine, or requiring companies that sell alcoholic beverages to supplement them with B vitamins in general or thiamine in particular, could avert many cases. Treatment
It was once assumed that anyone with KS would eventually need full-time care. This is still often the case, but rehabilitation can help regain some, albeit often limited, level of independence. Treatment involves the replacement or supplementation of thiamine by intravenous or intramuscular injection, together with proper nutrition and hydration. However, the amnesia and brain damage caused by the disease does not always respond to thiamine replacement therapy. In some cases, drug therapy is recommended.
In the fresh state its upper part is covered with a thin layer of cartilage, lined by a prolongation of the synovial membrane of the shoulder-joint; its lower portion gives insertion to the tendon of the latissimus dorsi muscle. It is deep and narrow above, and becomes shallow and a little broader as it descends. Its lips are called, respectively, the crests of the greater and lesser tubercles (bicipital ridges), and form the upper parts of the anterior and medial borders of the body of the bone. Shaft
The body or shaft of the humerus is triangular to cylindrical in cut section and is compressed anteroposteriorly. It has 3 surfaces, namely:

Anterolateral surface: the area between the lateral border of the humerus to the line drawn as a continuation of the crest of the greater tubercle. The antero-lateral surface is directed lateralward above, where it is smooth, rounded, and covered by the deltoid muscle; forward and lateralward below, where it is slightly concave from above downward, and gives origin to part of the Brachialis. About the middle of this surface is a rough, rectangular elevation, the deltoid tuberosity for the insertion of the deltoid muscle; below this is the radial sulcus, directed obliquely from behind, forward, and downward, and transmitting the radial nerve and profunda artery. Anteromedial surface: the area between the medial border of the humerus to the line drawn as a continuation of the crest of the greater tubercle.