Nevertheless, the failure to irrefutably demonstrate infectivity following intracerebral inoculation with urine from transmissible spongiform encephalopathy (TSE)-infected hosts suggests that the risk associated with products derived from urine is merely theoretical.Recombinant gonadotropins have to a large degree replaced hMG in fertility treatments. The recombinant process allows for the production of pure FSH or LH not "contaminated" by other proteins that may be present after urinary extraction. While some head-on studies seem not to suggest that "pure FSH" gives better results than hMG, others claim that recombinant FSH is more efficient and reduces costs. A Cochrane Collaboration analysis did not reveal major differences in clinical outcomes when comparing urinary versus recombinant FSH.The Practice Committee of the American Society for Reproductive Medicine reported: “Compared with earlier crude animal extracts, modern highly purified urinary and recombinant gonadotropin products have clearly superior quality, specific activity, and performance.
There are no confirmed differences in safety, purity, or clinical efficacy among the various available urinary or recombinant gonadotropin products.”

List of hMG preparations
A number of drug companies have and had marketed hMG preparations that include:
Gynogen HP (Sanzyme (P) Limited)Highly purified urinary FSH and LH in 1:1 ratioHumog (Bharat Serums And Vaccines Ltd)highly purified urinary FSH and LH in 1:1 ratioHumegon (Organon)
Menopur (Ferring Pharmaceuticals), 75 IU FSH and 75 IU LH activity
Merional, Meriofert (IBSA Institut)
Menogon
Metrodin (Serono)highly purified urinary FSHRepronex (Ferring Pharmaceuticals), 75 IU FSH and 75 IU LH
Pergonal (Serono),Pergonal was the major hMG prior to the arrival of recombinant gonadotropins containing 75 IU FSH and 75 IU LH.HMG Massone, 75 IU FSH and 75 IU LH

See also
Gonadotropin preparations


== References ==