While there is no cure for ICP, and no way to guarantee a successful outcome, studies have shown a slightly better fetal and maternal outcome from administration of ursodeoxycholic acid, whereas cholestyramine appears to only relieve itching.There is no evidence that giving oral water-soluble Vitamin K may help to avoid the risk of hemorrhage at delivery. However, experts in ICP will prescribe this if the woman reports pale stools, has very severe ICP (bile acids > 100 μmol/litre) or has a known clotting problem. Delivery from 34 weeks may be important to reduce the risk of stillbirth, as a recent study identified the level of bile acids at which stillbirth risk rises. This research, published in The Lancet, also suggests that around 90% of women with ICP could wait until 39 weeks of pregnancy to be induced. However, this relies on regular bile acid testing with rapid return of results. Risks if untreated
Maternal consequences include the following:

Itching, which can become intense and debilitating
Spontaneous premature labour when bile acids rise above 40 μmol/litreFetal consequences include:

Fetal distress
Meconium ingestion
StillbirthIn most cases induction is typically recommended anywhere from 34–39 weeks.In the United States, some researchers have suggested that the risk of stillbirth is lower if induction occurs at 36 weeks. Whilst Ovadias research suggests differently, it is important to note that in the United States bile acid tests can take up to seven days to be processed, and this means that it may be more prudent to base delivery on the US research.
Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of pregnancy, jaundice of pregnancy, and prurigo gravidarum, is a medical condition in which cholestasis occurs during pregnancy. It typically presents with itching and can lead to complications for both mother and baby. Pruritus (itching) is a common symptom of pregnancy, affecting around 23% of women. The majority of times, itching is a minor annoyance caused by changes to the skin, especially that of the abdomen. However, there are instances when itching may be a symptom of ICP. Although typically noticed on the palms of the hands and the soles of the feet, the itching can occur anywhere on the body. ICP occurs most commonly in the third trimester, but can begin at any time during the pregnancy. Signs and symptoms
Most women with this condition present in the third trimester (although it can present as early as seven weeks) with itching without a rash. Typically, the itching is localized to the palms of the hands and soles of the feet, but can be anywhere on the body. Hallmarks of ICP include the following symptoms:Most common:

Itching, in particular but not limited to that of the palms of the hands and soles of the feet, without presence of a rash
Itching that is more noticeable in the evening
Darker urineLess common:

Lighter stools
Increased clotting time (due to possibly associated vitamin K deficiency)
Fatigue
Increased nausea
Decrease in appetite
Jaundice (less than 10% of women)
Upper right quadrant painNot all ICP sufferers have all of the above symptoms.