Signs may include delayed relaxation of the ankle reflex and a slow heartbeat. A goiter may be present with a completely enlarged thyroid gland; sometimes only part of the thyroid is enlarged and it can be knobby. Related disorders
Thyroid hormone abnormalities are common in major psychiatric disorders including bipolar disorder; clinical research has shown there is a high rate of thyroid dysfunction in mood disorders and schizophrenia-spectrum disorders, concluding that there is a case for screening for the latter among people with thyroid illness. Causes
Hypothyroidism is caused by inadequate function of the gland itself (primary hypothyroidism), inadequate stimulation by thyroid-stimulating hormone from the pituitary gland (secondary hypothyroidism), or inadequate release of thyrotropin-releasing hormone from the brains hypothalamus (tertiary hypothyroidism). Primary hypothyroidism is about a thousandfold more common than central hypothyroidism.Iodine deficiency is the most common cause of primary hypothyroidism and endemic goiter worldwide. In areas of the world with sufficient dietary iodine, hypothyroidism is most commonly caused by the autoimmune disease Hashimotos thyroiditis (chronic autoimmune thyroiditis). Hashimotos may be associated with a goiter. It is characterized by infiltration of the thyroid gland with T lymphocytes and autoantibodies against specific thyroid antigens such as thyroid peroxidase, thyroglobulin and the TSH receptor.After women give birth, about 5% develop postpartum thyroiditis which can occur up to nine months afterwards.
Pes (Latin for "foot") or the acronym PES may refer to:

Pes
Pes (unit), a Roman unit of length measurement roughly corresponding with a foot
Pes or podatus, a Neume § Neumes representing two notes
Pes (rural locality), several rural localities in Russia
Pes (river), a river in northwestern Russia
Pes (anatomy), zoological term for the distal portion of the hind limb of tetrapod animals
Talipes equinovarus (pes equinovarus), clubfoot
Talipes cavus (pes cavus), clawfoot
Talipes planus (pes planus), flat feet
Talipes valgus (pes valgus), valgus deformity of the foot
Talipes varus (pes varus), varus deformity of the foot
Pes anserinus (leg)
Pes anserine bursitis, inflammatory of the inner knee at the bursa of the pes anserinus
Parotid plexus, pes anserinus of the facial nerve

PES
Education
PES University, formerly P.E.S.