It can be synthesized by the reaction of selenium tetrachloride (SeCl4) with [((CH3)3Si)2N]2Se.Selenium reacts with cyanides to yield selenocyanates:

  
    
      
        
          8
          
          KCN
          +
          
            Se
            
              8
            
            
              
            
          
          ⟶
          8
          
          KSeCN
        
      
    
    {\displaystyle {\ce {8 KCN + Se8 -> 8 KSeCN}}}

Organoselenium compounds
Selenium, especially in the II oxidation state, forms stable bonds to carbon, which are structurally analogous to the corresponding organosulfur compounds.
The cyclodextrin contained in the oral solution can cause an osmotic diarrhea, and if this is a problem, then half the dose can be given as oral solution and half as capsule to reduce the amount of cyclodextrin given. "Sporanox" itraconazole capsules should always be taken with food, as this improves absorption, however the manufacturers of "Lozanoc" assert that it may be taken "without regard to meals". Itraconazole oral solution should be taken an hour before food, or two hours after food (and likewise if a combination of capsules and oral solution are used). Itraconazole may be taken with orange juice or cola, as absorption is also improved by acid. Absorption of itraconazole is impaired when taken with an antacid, H2 blocker or proton pump inhibitor. Side effects
Itraconazole is a relatively well-tolerated drug (although not as well tolerated as fluconazole or voriconazole) and the range of adverse effects it produces is similar to the other azole antifungals:
elevated alanine aminotransferase levels are found in 4% of people taking itraconazole
"small but real risk" of developing congestive heart failure
liver failure, sometimes fatalThe cyclodextrin used to make the syrup preparation can cause diarrhea. Side effects that may indicate a greater problem include:

Interactions
The following drugs should not be taken with itraconazole:

Pharmacology
Pharmacodynamics
The mechanism of action of itraconazole is the same as the other azole antifungals: it inhibits the fungal-mediated synthesis of ergosterol, via inhibition of lanosterol 14α-demethylase.