The donkey died of the freezing temperatures and was only discovered in the spring, once the ice had melted; thus, it received the name Pagh Esh, or "Cold Donkey. "Baghesh was one of the most important cities of the Kingdom of Armenias province of Aghdznik, and it served as the primary fortress of the provinces canton of Salnodzor. Some medieval Armenian writers, such as Anania Shirakatsi and Vardan Areveltsi, later mention it as a part of the canton of Bznunik. The fortress guarded the Baghesh Pass, which linked the southern reaches of the Armenian Plateau to northern Mesopotamia. The Arabs conquered Baghesh at the end of the seventh century and it eventually became the capital of the Zurārid emirs of Arzan. Because it was on an important trade route, it prospered greatly. The next two centuries, however, marked a turbulent period in the towns history. After Bugha al-Kabirs destructive 852-855 campaign in Armenia, the Shaybanid emirs wrested control of Baghesh from the Zurārids; thereafter, in the first quarter of the tenth century, it was taken by the Kaysite emirs of Manzikert. In his 929-30 campaign against the Kaysites, the Byzantine general John Curcuas was able to capture and annex Baghesh. Following the devastation of the Arab emirs in the second half of the tenth century, a great number of Kurds settled in Baghesh and at the end of the tenth century, the city fell into the hands of the Kurdish Marwanid dynasty after breaking from Buyid rule.
Non-steroidal anti-inflammatory drugs (NSAIDs) have also been used. Hydroxychloroquine has proven effective in some cases. History
In a 1985 paper published in the Journal of the American Medical Association, McCarty and colleagues first described a case series of patients with this disorder, for which they coined the abbreviation RS3PE. RS3PE was initially thought to represent a form of seronegative rheumatoid arthritis but is now believed to be a separate syndrome. == References ==