Physicians can biopsy the skin with a 3-mm circular punch tool and immediately fix the specimen in 2% paraformaldehyde lysine-periodate or Zambonis fixative. Specimens are sent to a specialized laboratory for processing and analysis where the small nerve fibers are quantified by a neuropathologist to obtain a diagnostic result.This skin punch biopsy measurement technique is called intraepidermal nerve fiber density (IENFD). The following table describes the IENFD values in males and females of a 3 mm biopsy 10 cm above the lateral malleolus (above ankle outer side of leg). Any value measured below the 0.05 Quantile IENFD values per age span, is considered a reliable positive diagnosis for small fiber peripheral neuropathy. Treatment
Treatment is based on the underlying cause, if any. Where the likely underlying condition is known, treatment of this condition is indicated to reduce progression of the disease and symptoms. For cases without those conditions, there is only symptomatic treatment. See also
Neuropathy
Polyneuropathy
Wartenbergs migratory sensory neuropathy
Burning feet syndrome
Electrochemical skin conductance

References
External links

Peripheral Neuropathy Fact Sheet – NINDS
[1]
Gustatory hyperhidrosis is excessive sweating classified under focal hyperhidrosis, that is, it is restricted to certain regions of the body. Affected people regularly experience this on the forehead (scalp), upper lip, perioral region, or sternum a few moments after eating spicy foods, tomato sauce, chocolate, coffee, tea, or hot soups.A common cause is trauma or damage to the nerve that passes through the parotid gland, which can be due to surgery of the parotid gland (parotidectomy). This type of sweating is known as Freys syndrome. Gustatory hyperhidrosis has been observed in diabetics with autonomic neuropathy, and a variant of this disorder has been reported following surgical sympathectomy.Around 10% of affected people require treatment. One of the more effective treatments is oral or topically applied glycopyrrolate. == References ==