Insects of the superorder Endopterygota, also known as Holometabola, such as butterflies, ants, bees, beetles, fleas, flies, moths, and wasps, undergo holometabolism—complete metamorphism in four stages—from (1) embryo (ovum, egg), to (2) larva (such as grub, caterpillar), then (3) pupa (such as the chrysalis), and finally (4) the imago. In the common ABO blood group system, there are four blood types (A, B, O, AB). Humans have four canines and four wisdom teeth. The cows stomach is divided in four digestive compartments: reticulum, rumen, omasum and abomasum. In chemistry
Valency of carbon (that is basis of life on the Earth) is four. Also because of its tetrahedral crystal bond structure, diamond (one of the natural allotropes of carbon) is the hardest known naturally occurring material. It is also the valence of silicon, whose compounds form the majority of the mass of the Earths crust. The atomic number of beryllium
There are four basic states of matter: solid, liquid, gas, and plasma. In physics
Special relativity and general relativity treat nature as four-dimensional: 3D regular space and one-dimensional time are treated together and called spacetime. Also, any event E has a light cone composed of four zones of possible communication and cause and effect (outside the light cone is strictly incommunicado). There are four fundamental forces (electromagnetism, gravitation, the weak nuclear force, and the strong nuclear force). In statistical mechanics, the four functions inequality is an inequality for four functions on a finite distributive lattice.
Moreover, LPR patients may try to compensate for their hoarseness by increasing muscular tension in their vocal tract. This hyper-functional technique adopted in response to the inflammation caused by LPR can lead to a condition called muscle tension dysphonia and may persist even after the hoarseness and inflammation has disappeared. A speech-language pathologist will often need to be involved to help resolve this maladaptive, compensatory pattern through the implementation of voice therapy.LPR presents as a chronic and intermittent disease in children. LPR in children and infants tends to manifest with a unique set of symptoms. Symptoms seen in children with LPR include a cough, hoarseness, stridor, sore throat, asthma, vomiting, globus sensation, wheezing, aspiration and recurrent pneumonia. Common symptoms of LPR in infants include wheezing, stridor, persistent or recurrent cough, apnea, feeding difficulties, aspiration, regurgitation, and failure to thrive. Moreover, LPR in children is commonly concomitant with laryngeal disorders such as laryngomalacia, subglottic stenosis, and laryngeal papillomatosis. Relationship to GERD
LPR is often regarded as a subtype of GERD that occurs when stomach contents flow upward through the esophagus and reach the level of the larynx and pharynx. However, LPR is associated with a distinct presentation of symptoms. LPR and GERD frequently differ in the relative prevalence of heartburn and throat clearing. While heartburn is present in over 80% of GERD cases, it occurs in only 20% of LPR cases. Throat clearing shows the opposite prevalence pattern, occurring in approximately 87% of LPR cases and in fewer than 5% of GERD cases.