Approximately 30%-79% of people with the disease display symptoms of abnormality of the retinal pigmentation, ataxia, muscular hypotonia or reduced tendon reflexes.The signs and symptoms of abetalipoproteinemia appear in the first few months of life (because pancreatic lipase is not active in this period). They can include failure to gain weight and grow at the expected rate (failure to thrive); diarrhea; abnormal spiny red blood cells (acanthocytosis); and fatty, foul-smelling stools (steatorrhea). The stool may contain large chunks of fat and/or blood. Infants often present with gastrointestinal problems caused by the poor fat absorption, which also contributes to steatorrhea. Other features of this disorder may develop later in childhood and often impair the function of the nervous system. They can include poor muscle coordination, difficulty with balance and movement (ataxia), and progressive degeneration of the retina (the light-sensitive layer in the posterior eye) that can progress to near-blindness (due to deficiency of vitamin A, retinol). Adults in their thirties or forties may have increasing difficulty with balance and walking. Many of the signs and symptoms of abetalipoproteinemia result from a severe vitamin deficiency, especially vitamin E deficiency, which typically results in eye problems with degeneration of the spinocerebellar and dorsal column tracts. Genetics
Mutations in the microsomal triglyceride transfer protein (MTTP) gene has been associated with this condition. (apolipoprotein B deficiency, a related condition, is associated with deficiencies of apolipoprotein B. )The MTTP gene provides instructions for making a protein called microsomal triglyceride transfer protein, which is essential for creating beta-lipoproteins.
The FDA also required manufacturers on all paracetamol containing products to issue a black box warning indicating the potential risk for severe liver injury and a warning highlighting potential for allergic reactions.On 22 August 2014, the Drug Enforcement Administration (DEA) announced that all hydrocodone combination products (HCPs) will be rescheduled from Schedule III to Schedule II of the Controlled Substances Act (CSA), effective on 6 October 2014. In 2010, more than 16,000 deaths were attributed to abuse of opioid drugs. Even though there are legitimate medical uses for HCPs, data suggest that a significant number of individuals misuse them. Popular culture
Vicodin is mentioned in songs such as Juice Wrlds "Already Dead" Eminems "Kill You", Blackbears "Sniffing Vicodin in Paris", Kendrick Lamars "A.D.H.D", Futures "Lay Up", Lupe Fiascos "Mural", Queens of the Stone Ages "Feel Good Hit of the Summer", A Winged Victory for the Sullens "Steep Hills of Vicodin Tears", Death Gripss "Anne Bonny" and The Wombats "Give Me a Try". Vicodin use is a central theme in the 2004–2012 medical TV drama House, in which the lead character Dr. Gregory House is addicted to the drug combination. Brand names
Brand names include Adol, Hycet, Lortab, Lorcet, Norco, and Vicodin among others. See also
Hydrocodone/aspirin
Hydrocodone/ibuprofen
Oxycodone/paracetamol

References
External links
"Acetaminophen mixture with Hydrocodone bitartrate". Drug Information Portal. U.S. National Library of Medicine. Vicodin U.S. Federal Regulations Archived 18 January 2017 at the Wayback Machine