NAFLD sensitizes the liver to injury and increases the risk of developing acute or chronic liver failure following another liver injury.Other rare hepatobiliary manifestations of Crohns disease include: cholangiocarcinoma, granulomatous hepatitis, cholelithiasis, autoimmune hepatitis, hepatic abscess, and pericholangitis.Renal and Urological
Nephrolithiasis, obstructive uropathy, and fistulization of the urinary tract directly result from the underlying disease process. Nephrolithiasis is due to calcium oxalate or uric acid stones. Calcium oxalate is due to hyperoxaluria typically associated with either distal ileal CD or ileal resection. Oxalate absorption increases in the presence of unabsorbed fatty acids in the colon. The fatty acids compete with oxalate to bind calcium, displacing the oxalate, which can then be absorbed as unbound sodium oxalate across colonocytes and excreted into the urine. Because sodium oxalate only is absorbed in the colon, calcium-oxalate stones form only in patients with an intact colon. Patients with an ileostomy are prone to formation of uric-acid stones because of frequent dehydration. The sudden onset of severe abdominal, back, or flank pain in patients with IBD, particularly if different from the usual discomfort, should lead to inclusion of a renal stone in the differential diagnosis.Urological manifestations in patients with IBD may include ureteral calculi, enterovesical fistula, perivesical infection, perinephric abscess, and obstructive uropathy with hydronephrosis. Ureteral compression is associated with retroperitoneal extension of the phlegmonous inflammatory process involving the terminal ileum and cecum, and may result in hydronephrosis severe enough to cause hypertension.Immune complex glomerulonephritis presenting with proteinuria and hematuria has been described in children and adults with CD or UC.
Trigeminal trophic syndrome is a rare disease caused by the interruption of peripheral or central sensory pathways of the trigeminal nerve. A slowly enlarging, uninflammed ulcer can occur in the area that has had trigeminal nerve damage; including but not limited to the cheek beside the ala nasi. : 65  These sores affect the skin supplied by the sensory component of the trigeminal nerve. Similar lesions may also occur in the corners of the eyes, inside the ear canal, on the scalp or inside the mouth.It has been stated that the ulceration is due to the constant "picking" of the patient. While this does occur, the picking behavior is an incomplete explanation of the disease presentation: the lack of feeling or pain allows the patient to continue scratching or picking the area, and, although there is no feeling, there is constant neuropathic pain.Sixty cases were reported from 1982 to 2002. See also
Trigeminal neuralgia (Tic douloureux)
Skin lesion
List of cutaneous conditions
Somatosensory system


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