Four of these occur in East Africa, one in East Asia and one in Europe and North America. This suggests that the virus may have originated in East Africa. The most recent common ancestor of the Eurasian strains appears to have evolved ~60,000 years ago. The East Asian HSV-1 isolates have an unusual pattern that is currently best explained by the two waves of migration responsible for the peopling of Japan.Herpes simplex 2 genomes can be divided into two groups: one is globally distributed and the other is mostly limited to sub Saharan Africa. The globally distributed genotype has undergone four ancient recombinations with herpes simplex 1. It has also been reported that HSV-1 and HSV-2 can have contemporary and stable recombination events in hosts simultaneously infected with both pathogens. All of the cases are HSV-2 acquiring parts of the HSV-1 genome, sometimes changing parts of its antigen epitope in the process.The mutation rate has been estimated to be ~1.38×10−7 substitutions/site/year. In clinical setting, the mutations in either the thymidine kinase gene or DNA polymerase gene has caused resistance to aciclovir. However, most of the mutations occur in the thymidine kinase gene rather than the DNA polymerase gene.Another analysis has estimated the mutation rate in the herpes simplex 1 genome to be 1.82×10−8 nucleotide substitution per site per year. This analysis placed the most recent common ancestor of this virus ~710,000 years ago.Herpes simplex 1 and 2 diverged about 6 million years ago.
Shake may refer to:

Handshake
Milkshake
Tremor
Shakes (wood), cracks in timber
Shake (shingle), a wooden shingle made from split logsShake, The Shakes, Shaking, or Shakin may refer to:

Geography
Shake, Zimbabwe
Shake, another name for Sake language, used in parts of Gabon

People
Shakin Stevens, Welsh rock and roll singer
Anthony "Shake" Shakir, Detroit techno producer
Master Shake, a character in Aqua Teen Hunger Force
Shake (singer) (Sheikh Abdullah Ahmad), Malaysian singer
Shaking, a stage name of Xie Keyin, Chinese singer, rapper and songwriter
Malik "Shake" Milton, American basketball player

Music
Shake (music) (more commonly known as a trill), a musical ornament
The Shake (dance), a fad dance of the 1960s
The Shake (American rock band)

Albums
Shake (The Thing album) (2015)
Shake (John Schlitt album) (1995)
Shake! (album) (1968), by the Siegel–Schwall Band
Shake (2001), by Zucchero Fornaciari
Shakin (album), 1986 work by country music group Sawyer Brown
The Shake (Laurie Johnson), an LP by Laurie Johnson, the base of what is now known as "The Avengers Theme"

Songs
"Shake" (Sam Cooke song) (1964), notably covered by Otis Redding
"Shake!"