Likewise, with the depressed patient, electroconvulsive therapy (ECT) is more effective than pharmacotherapy.Cotards syndrome resulting from an adverse drug reaction to valacyclovir is attributed to elevated serum concentration of one of valacyclovirs metabolites, 9-carboxymethoxymethylguanine (CMMG). Successful treatment warrants cessation of valacyclovir. Hemodialysis was associated with timely clearance of CMMG and resolution of symptoms. Case studies
Society and culture
The protagonist of Charlie Kaufmans 2008 movie Synecdoche, New York, is named Caden Cotard. Throughout the film Cotard thinks he is dying, and we see other examples of Cotard delusion with scenes such as when his daughter, Olive, begins to scream about having blood in her body and, as the film goes on, Cotard disappears from the play he is writing about his own life and is portrayed by other actors as he takes the role of a cleaning lady.It is speculated that Per "Dead" Ohlin, lead vocalist for the black metal bands Mayhem and Morbid, had Cotard delusion as a result of a bullying incident in his youth that left him clinically dead for a short time. He developed an obsession with death shortly after (hence his stage name and use of corpse paint), often self-harmed onstage and among friends, and became increasingly depressed and introverted eventually resulting in his suicide in 1991. His suicide note contained the lines "I belong in the woods and have always done so. No one will understand the reason for this anyway. To give some semblance of an explanation Im not a human, this is just a dream and soon I will wake."
History
Insulin lispro (brand name Humalog) was granted marketing authorization in the European Union in April 1996, and it was approved for use in the United States in June 1996.Insulin lispro (brand name Liprolog) was granted marketing authorization in the European Union in May 1997, and again in August 2001.Combination drugs combining insulin lispro and other forms of insulin were approved for use in the United States in December 1999.Insulin lispro Sanofi was granted marketing authorization as a biosimilar in the European Union in July 2017.Insulin lispro injection (brand name Admelog) was approved for use in the United States in December 2017.In January 2020, the Committee for Medicinal Products for Human Use (CHMP) in the European Union recommended granting of a marketing authorization for insulin lispro acid (brand name Lyumjev) for the treatment of diabetes mellitus in adults. Insulin lispro (Lyumjev) was approved for use in the European Union in March 2020, and in the United States on 18 June 2020 as reported by Medscape. References
External links
"Insulin lispro". Drug Information Portal. U.S. National Library of Medicine.