From Perugia the phenomenon seemed to spread across Northern Italy and into Austria. Other incidents are recorded in 1296, 1333-34 (the Doves), notably at the time of the Black Death (1349), and 1399. The practice peaked during the Black Death. Spontaneously Flagellant groups arose across Northern and Central Europe in 1349, including in England.Initially the Catholic Church tolerated the Flagellants and individual monks and priests joined in the early movements. By the 14th century, the Church was less tolerant and the rapid spread of the movement was alarming. Clement VI officially condemned them in a bull of October 20, 1349 and instructed Church leaders to suppress the Flagellants. This position was reinforced in 1372 by Gregory XI who associated the Flagellants with other heretical groups, notably the Beghards, and instructed inquisitors to eradicate them. They were accused of heresies including doubting the need for the sacraments, denying ordinary ecclesiastical jurisdiction and claiming to work miracles. In 1392, a sect of Flagellants and Beghards, consisting of peasants, were found throughout Swabia and Wurzburg. The papal inquisitor imposed the penance of preaching and joining a crusade against the Ottoman Turks.The Inquisition was active against any revival of the movement in the 15th century, but action against the flagellants was often taken by the local princes. In 1414, 80–90 followers of Konrad Schmid were burned in Thuringia, in Germany, even though they had recanted. Three hundred were burnt in one day in 1416, also in Thuringia.
If symptoms are infrequent, other forms of continuous heart beat recording may be used, such as a 24 or 48-hour Holter monitor  or even 14- to 30-day recorders if the symptoms are very occasional. The advantage of these monitors is that they allow a quantification of the amount of abnormal beats ("burden") and ensure that there are no heart arrhythmias present that might require attention, such as ventricular tachycardia. If symptoms are associated with exercise, a supervised cardiac stress test may be required to reproduce the abnormality. Specifically, if this shows exercise-induced ventricular tachycardia this would require specific treatment. If PVCs are suppressed by exercise, this is an encouraging finding.On electrocardiography (ECG or Holter) premature ventricular contractions have a specific appearance of the QRS complexes and T waves, which are different from normal readings. By definition, a PVC occurs earlier than the regular normally conducted beat. Subsequently, the time between the PVC and the next normal beat is longer as the result of a compensatory pause. PVCs can be distinguished from premature atrial contractions because the compensatory pause is longer following premature ventricular contractions, in addition to a difference in QRS appearance.In some people, PVCs occur in a predictable pattern. Two PVCs in a row are called doublets and three PVCs in a rows are triplets. Depending whether there are one, two, or three normal (sinus) beats between each PVC, the rhythm is called bigeminy, trigeminy, or quadrigeminy. If 3 or more consecutive PVCs occur in a row it may be called ventricular tachycardia.