While this will not resolve or improve the edema, the cessation of smoking will halt the diseases progression.If the elimination of risk factors is not sufficient to improve the patients symptoms, surgery may be required. The most common type of surgery performed today for Reinkes edema is called surgical microlaryngoscopy. Most procedures follow the microflap technique set in place by Hirano. During surgery, an incision is made into the vocal cord using either microscissors or a CO2 laser. A flap of mucosa is lifted and the affected tissue is removed using suction or a microdebrider. The flap is then re-draped and trimmed to the appropriate size.Most cases of Reinkes Edema are bilateral - affecting both vocal cords - rather than unilateral. In the case of bilateral edema, the surgeon must choose whether to operate each side of the vocal cord in two separate surgeries or to operate both sides in a single surgery. The complication associated with removing tissue from both sides in a single surgery is that the raw, cut ends of the vocal cords may form an anterior glottis web, in which the two sides grow together in a continuous sheet. Other complications of surgery include tissue scarring due to damage to the vocal ligament during the incision and vocal cord stiffening due to over-suctioning of the superficial lamina propria (Reinkes space).While surgical microlaryngoscopy has its associated risks, if left untreated, Reinkes edema can lead to a variety of long-term complications.
Diclofenac/misoprostol, sold under the brand name Arthrotec, is a fixed-dose combination medication that contains:

Diclofenac sodium: Nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties
Misoprostol: Gastrointestinal (GI) mucosal protective prostaglandin E1 analog.In the United Kingdom it is marketed by Pharmacia and it is indicated for prophylaxis against NSAID-induced gastroduodenal ulceration in people requiring diclofenac for rheumatoid arthritis or osteoarthritis.The American College of Rheumatology and a Canadian consensus report both recommend GI-protective agents such as misoprostol be combined with long term NSAID therapy and a review concluded that diclofenac/misoprostol is a cost effective treatment in patients requiring long term NSAID therapy who are at increased risk of developing gastropathy. Contraindications
Arthrotec must not be taken during pregnancy, as it may deform or otherwise harm the fetus, or lead to miscarriage. This may be accompanied by potentially dangerous bleeding, possibly requiring surgery and potentially leading to infertility or death. References
External links
"Diclofenac mixture with misoprostol". Drug Information Portal. U.S. National Library of Medicine.