These two neural networks are seen to be dysfunctionally operative in the limbic system, but the specific regions vary widely in individuals, which calls for the analysis of more neuroimaging studies.Also (contrary to the results of earlier studies) those with BPD showed less activation in the amygdala in situations of increased negative emotionality than the control group. John Krystal, editor of the journal Biological Psychiatry, wrote that these results "[added] to the impression that people with borderline personality disorder are set-up by their brains to have stormy emotional lives, although not necessarily unhappy or unproductive lives". Their emotional instability has been found to correlate with differences in several brain regions. Mediating and moderating factors
Executive function
While high rejection sensitivity is associated with stronger symptoms of borderline personality disorder, executive function appears to mediate the relationship between rejection sensitivity and BPD symptoms. That is, a group of cognitive processes that include planning, working memory, attention, and problem-solving might be the mechanism through which rejection sensitivity impacts BPD symptoms. A 2008 study found that the relationship between a persons rejection sensitivity and BPD symptoms was stronger when executive function was lower and that the relationship was weaker when executive function was higher. This suggests that high executive function might help protect people with high rejection sensitivity against symptoms of BPD. A 2012 study found that problems in working memory might contribute to greater impulsivity in people with BPD. Family environment
Family environment mediates the effect of child sexual abuse on the development of BPD.
Some of the surgeries may include duodenojejunostomy, laparoscopic duodenojejunostomy, or laparoscopic surgery.The timeline for recovery is 7 weeks. Epidemiology
No statistical information has been identified. Megaduodenum is an uncommon disease, and because of its extreme rarity of the condition only few cases has been reported in the literatures. Current Research
Since Megaduodenum is a rare disease, treatments and decisions are made based on the patients initial conditions and their responses to the provided treatments or surgeries.There are currently several ongoing clinical trials for megaduodenum. One study involves research of idiopathic megaduodenum in children which is a rare condition. The purpose of this study is to present the management of idiopathic megaduodenum in children. References
Further reading
Basilisco, G (1997). "Hereditary megaduodenum". The American Journal of Gastroenterology. 92 (1): 150–3. PMID 8995957. Law, David H.; Ten Eyck, Edward A. (1962). "Familial megaduodenum and megacystis". The American Journal of Medicine. 33 (6): 911. doi:10.1016/0002-9343(62)90222-X. Sturtevant, Mills (1939). "Megaduodenum and Duodenal Obstruction: Criteria for Diagnosis". Radiology. 33 (2): 185–8. doi:10.1148/33.2.185. Raia, Arrigo; Acquaroni, Danilo; Netto, Alipio Correa (1961). "Pathogenesis and treatment of acquired megaduodenum". The American Journal of Digestive Diseases. 6 (8): 757–71. doi:10.1007/BF02231059. PMID 13739156. S2CID 7354820. Gillespie, H. W. (1939). "Megaduodenum and Gastromegaly". British Journal of Radiology. 12 (136): 221–4. doi:10.1259/0007-1285-12-136-221. == External links ==