Society and culture
In the film Orchids, My Intersex Adventure, Phoebe Hart and her sister Bonnie Hart, both women with CAIS, documented their exploration of AIS and other intersex issues.Recording artist Dalea is a Hispanic-American Activist who is public about her CAIS. She has given interviews about her condition and founded Girl Comet, a non-profit diversity awareness and inspiration initiative.In 2017, fashion model Hanne Gaby Odiele disclosed that they were born with the intersex trait androgen insensitivity syndrome. As a child, they underwent medical procedures relating to the condition, which they said took place without their or their parents informed consent. They were told about their intersex condition weeks before beginning their modelling career.In the 1991 Japanese horror novel Ring and its sequels, by Koji Suzuki (later adapted into Japanese, Korean, and American films), the central antagonist Sadako has this syndrome, as revealed by Dr Nagao when confronted by Ryuji and Asakawa. Sadakos condition is referred to by the earlier name "testicular feminisation syndrome". In season 2, episode 13 ("Skin Deep") of the TV series House, the main patients cancerous testicle is mistaken for an ovary due to the patients undiscovered CAIS.In season 2 of the MTV series Faking It, a character has CAIS.
A marked decrease in myoclonus and some normalization of somatosensory evoked potentials with acetylcysteine treatment has been documented. Addiction to certain addictive drugs (including cocaine, heroin, alcohol, and nicotine) is correlated with a persistent reduction in the expression of excitatory amino acid transporter 2 (EAAT2) in the nucleus accumbens (NAcc); the reduced expression of EAAT2 in this region is implicated in addictive drug-seeking behavior. In particular, the long-term dysregulation of glutamate neurotransmission in the NAcc of addicts is associated with an increase in vulnerability to relapse after re-exposure to the addictive drug or its associated drug cues. Drugs that help to normalize the expression of EAAT2 in this region, such as N-acetylcysteine, have been proposed as an adjunct therapy for the treatment of addiction to cocaine, nicotine, alcohol, and other drugs. It is being tested for the reduction of hangover symptoms, but the clinical trial results are still being evaluated. A double-blind placebo controlled trial of 262 patients has shown NAC treatment was well-tolerated and resulted in a significant decrease in the frequency of influenza-like episodes, severity, and length of time confined to bed. COVID-19
NAC is being considered as a possible treatment for COVID-19. References
External links
"Acetylcysteine". Drug Information Portal. U.S. National Library of Medicine.