Treatment
The primary goal of surgical intervention is to allow normal cranial vault development to occur. This can be achieved by excision of the prematurely fused suture and correction of the associated skull deformities. If the synostosis goes uncorrected, the deformity will progressively worsen not only threatening the aesthetic aspect, but also the functional aspect. This is especially prevalent with asymmetric conditions, such as unilateral coronal synostosis, with compromised function of the eyes and the jaw. In addition, signs of compromised neurodevelopment have been seen amongst all the synostoses, although this may also be caused by primary maldevelopment of the brain and can thus not be prevented by surgical intervention.There are a few basic elements involved in surgical intervention which is aimed at normalization of the cranial vault:

Surgery for craniosynostosis is often associated with significant perioperative hemorrhage so multiple strategies are often used to minimize blood loss. One such method involves the injection of vasoconstrictive agents (i.e. epinephrine) seven to ten minutes before scalp incision. Additionally, the initiation of surgery should be delayed until blood products are physically present in the operating room. Another general agreement is the avoidance of the use of titanium plates in the fixation of the skull. One potential complication following this procedure involves the gradual movement of the titanium plates towards the brain, induced by resorption of the innermost bone layer of the skull with deposition of new bone on the outermost layer, thereby integrating the titanium plates.
Thymus hyperplasia refers to an enlargement ("hyperplasia") of the thymus.It is not always a disease state. The size of the thymus usually peaks during adolescence and atrophies in the following decades. Before the immune function of the thymus was well understood, the enlargement was sometimes seen as a cause for alarm, and justification for surgical reduction. This approach is much less common today. It can be associated with myasthenia gravis. Magnetic Resonance Imaging can be used to distinguish it from thymoma. Thymic hyperplasia
Thymic hyperplasia can be divided into three groups namely, those without any pre-existing medical condition, those recovering from a pre-existing medical condition such as pneumonia, corticosteroid therapy, radiation therapy, chemotherapy, surgery, and burns, and those with other disorders such as  hyperthyroidism, sarcoidosis, or pure red cell aplasia. References


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