Many opponents believe that replacement drugs only substitute one addiction with another, and that methadone can be manipulated and exploited in some cases. Long-term usage has the ability to cause brain changes. Methadone causes changes in thought, cognitive performance, and memory by influencing nerve cells in the brain. An initial review is performed during alcohol therapy. The person will be evaluated and interviewed during this evaluation, and then the treatment team will then devise the optimal treatment plan for that individual. Methadone 
Methadone is a drug used for both opioid overuse treatment and for chronic pain, it is known as a full opioid agonist. Methadone is the most common prescribed out of all the medications used for addiction; this is due to the fact that it has more advantages and less disadvantages than the other medications. Due to methadones longer half life, it is much more challenging to prescribe dosage amounts compared to others. The long half life has good benefits, one of these benefits being the fact that if a dose is missed in the 24 hours of the last, the patient will not typically struggle with withdrawal symptoms quite yet. Methadone can be found in a couple different forms: tablet, oral solution, or an injection. The first time this medication was put to use was during World War II, it was a safer alternative to morphine. Buprenorphine
Buprenorphine is a partial opioid receptor agonist. Unlike methadone and other full opioid receptor agonists, buprenorphine is less likely to cause respiratory depression due to its ceiling effect.
Lenticonus  (/len·ti·co·nus/ (len″tĭ-ko´nus)) [lens + L. conus, cone] is a rare congenital anomaly of the eye characterized by a conical protrusion on the crystalline lens capsule and the underlying cortex. It can reach a diameter of 2 to 7 mm. The conus may occur anteriorly or posteriorly. If the bulging is spherical, instead of conical, the condition is referred to as lentiglobus. It produces a decrease in visual acuity and irregular refraction that cannot be corrected by either spectacle or contact lenses.Biomicroscopically lenticonus is characterized by a transparent, localized, sharply demarcated conical projection of the lens capsule and cortex, usually axial in localization. In an early stage, retro-illumination shows an oil dropletconfiguration. Using a narrow slit, the image of a conus is observed. In a more advanced stage associated subcapsular and cortical opacities appear. Retinoscopically the oil droplet produces a pathognomonic scissors movement of the light reflex. This phenomenon is due to the different refraction in the central and the peripheral area of the lens. Ultrasonography also can illustrate the existence of a lenticonus. A-scan ultrasonography may reveal an increased lens thickness and B- scanultrasonography may show herniated lenticular material, suggestive of a lenticonus. Amblyopia, cataract, strabismus and loss of central fixation may be observed in association with lenticonus posterior. Cataract, flecked retinopathy, posterior polymorphous dystrophy and corneal arcus juvenilis may be encountered in association with lenticonus anterior that occurs as a part of the Alport syndrome.There exist two distinct types of lenticonus based on the face of the lens affected.