People with the condition usually present with a painless swelling in the area of the clavicles at 2–3 years of age. Common features are:

Clavicles (collarbones) can be partly missing leaving only the medial part of the bone. In 10% of cases, they are completely missing. If the collarbones are completely missing or reduced to small vestiges, this allows hypermobility of the shoulders including ability to touch the shoulders together in front of the chest. The defect is bilateral 80% of the time. Partial collarbones may cause nerve damage symptoms and therefore have to be removed by surgery. The mandible is prognathic due to hypoplasia of maxilla (micrognathism) and other facial bones. A soft spot or larger soft area in the top of the head where the fontanelle failed to close, or the fontanelle closes late. Bones and joints are underdeveloped. People are shorter and their frames are smaller than their siblings who do not have the condition. The permanent teeth include supernumerary teeth. Unless these supernumeraries are removed they will crowd the adult teeth in what already may be an underdeveloped jaw. If so, the supernumeraries will probably need to be removed to make space for the adult teeth. Up to 13 supernumerary teeth have been observed. Teeth may also be displaced. Cementum formation may be deficient. Failure of eruption of permanent teeth. Bossing (bulging) of the forehead. Open skull sutures, large fontanelles. Hypertelorism. Delayed ossification of bones forming symphysis pubis, producing a widened symphysis. Coxa vara can occur, limiting abduction and causing Trendelenburg gait.
Inflammation may sometimes play a role in the development of depression, and LPS is pro-inflammatory. Cellular senescence
Inflammation induced by LPS can induce cellular senescence, as has been shown for the lung epithelial cells and microglial cells (the latter leading to neurodegeneration). Role as contaminant in biotechnology and research
Lipopolysaccharides are frequent contaminants in plasmid DNA prepared from bacteria or proteins expressed from bacteria, and must be removed from the DNA or protein to avoid contaminating experiments and to avoid toxicity of products manufactured using industrial fermentation.Ovalbumin is frequently contaminated with endotoxins. Ovalbumin is one of the extensively studied proteins in animal models and also an established model allergen for airway hyper-responsiveness (AHR). Commercially available ovalbumin that is contaminated with LPS can falsify research results, as it does not accurately reflect the effect of the protein antigen on animal physiology.In pharmaceutical production, it is necessary to remove all traces of endotoxin from drug product containers, as even small amounts of endotoxin will cause illness in humans. A depyrogenation oven is used for this purpose. Temperatures in excess of 300 °C are required to fully break down LPS.The standard assay for detecting presence of endotoxin is the Limulus Amebocyte Lysate (LAL) assay, utilizing blood from the Horseshoe crab (Limulus polyphemus). Very low levels of LPS can cause coagulation of the limulus lysate due to a powerful amplification through an enzymatic cascade.