People with HHS can be dehydrated by 8 to 12 liters. Attempts to correct this usually take place over 24 hours with initial rates of normal saline often in the range of 1 L/h for the first few hours or until the condition stabilizes. Electrolyte replacement
Potassium replacement is often required as the metabolic problems are corrected. It is generally replaced at a rate 10 mEq per hour as long as there is adequate urinary output. Insulin
Insulin is given to reduce blood glucose concentration; however, as it also causes the movement of potassium into cells, serum potassium levels must be sufficiently high or dangerously low blood potassium levels may result. Once potassium levels have been verified to be greater than 3.3 mEq/L, then an insulin infusion of 0.1 units/kg/hr is started. The goal for resolution is a blood glucose of less than 200 mg/dL. References


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Outdoor activities such as hiking, camping, or hunting where plague-infected animals may be found, increase the risk of contracting septicemic plague, and so do certain occupations such as veterinary or other animal-related work. Diagnosis
A doctor or veterinarian will perform a physical exam which includes asking about the medical history and possible sources of exposure. The following possible test could include:

Blood samples (detecting antibodies)
Culture samples of body fluids (check for the bacteria Yersinia pestis)
Kidney and liver testing
Checking lymphatic system for signs of infection
Examining body fluids for abnormal signs
Checking for swelling
Checking for signs of dehydration
Checking for fever
Checking for lung infection

Prevention
The following steps and precautions should be used to avoid infection of the septicemic plague:
Caregivers of infected patients should wear masks, gloves, goggles and gowns
Take antibiotics if close contact with infected patient has occurred
Use insecticides throughout house
Avoid contact with dead rodents or sick cats
Set traps if mice or rats are present around the house
Do not allow family pets to roam in areas where plague is common
Flea control and treatment for animals (especially rodents)

Treatment
Starting antibiotics early is a first step in treating septicemic plague in humans. One of the following antibiotics may be used:
Streptomycin
Gentamicin
Tetracycline or Doxycycline
Chloramphenicol
CiprofloxacinLymph nodes may require draining and the patient will need close monitoring.In animals, antibiotics such as tetracycline or doxycycline can be used. Intravenous drip may be used to assist in dehydration scenarios. Flea treatment can also be used. In some cases euthanasia may be the best option for treatment and to prevent further spreading. Prognosis
Untreated septicemic plague is almost always fatal.