People easily adapt to this weakness without conscious effort or self-awareness, by using 1) the next muscles down, which are innervated by a different nerve, or 2) using ligaments to give resistance, pinching laterally against the index finger or against the side of the end of the thumb, or 3) by what is called "tenodesis," which in this case is extension of the wrist joint, which tightens the muscles on the palm side of the hand. These adaptations on a moment-to-moment basis do not cause problems, but over time in loose-jointed patients, such as many women and people with collagen disorders such as Ehlers Danlos Syndrome, the adaptations can cause soft tissue failures that can become painful, particularly at the base of the thumb and in the proximal forearm (i.e., "Tennis Elbow" in a non-tennis player). Causes
The most common cause is entrapment of the median nerve between the two heads of the pronator teres muscle. Other causes are compression of the nerve from the fibrous arch of the flexor superficialis, or the thickening of the bicipital aponeurosis.⁠

Anatomy
The median nerve passes through the cubital fossa and passes between the two heads of pronator teres muscle into the forearm. It then runs between flexor digitorum superficialis and flexor digitorum profundus muscles and enters the hand through the carpal tunnel.It innervates most of the flexor muscles in the forearm and hand.
A supernumerary nipple  is an additional instance of nipple occurring in mammals, including humans. They are often mistaken for moles. Studies variously report the prevalence of supernumerary nipples as approximately 1 in 18 and 1 in 40.The nipples appear along the two vertical "milk lines", which start in the armpit on each side, run down through the typical nipples and end at the groin. They are classified into eight levels of completeness from a simple patch of hair to a milk-bearing breast in miniature. Types
Polythelia refers to the presence of an additional nipple alone while polymastia denotes the much rarer presence of additional mammary glands. Although usually presenting on the milk line, pseudomamma can appear as far away as the foot.A possible relationship with mitral valve prolapse has been proposed. Clinical significance
Clinical presentation
May remain undetected. Occasionally, the supernumerary nipple is noticed when hormonal changes during adolescence, menstruation, or pregnancy cause increased pigmentation, fluctuating swelling, tenderness, or even lactation. Associations
It is said to be found in association with many syndromes and other conditions:

McKusick–Kaufman syndrome
Char syndrome
Simpson–Golabi–Behmel syndrome

Treatment and prognosis
Most often no treatment is required; however, a protruding embarrassing supernumerary nipple can be removed surgically, if desired. Removal using liquid nitrogen cryotherapy has also been described. Society and culture
Television
The Triple Nipple Club is a documentary shown on Channel 4 which explored the biological mystery of the supernumerary nipple. First broadcast on 2 January 2008, it was directed and produced by Dan Louw and commissioned as part of Channel 4s First Cut series.