A phase II/III clinical trial began in 2014.In 2017, a 44-year-old  patient with MPS II was treated with gene therapy in an attempt to prevent further damage by the disease. This is the first case of gene therapy being used in vivo in humans. The study was extended to six patients in 2018. Society
On 24 July 2004, Andrew Wragg, 38, of Worthing, West Sussex, England, suffocated his 10-year-old son Jacob with a pillow, because of the boys disabilities related to MPS II. A military security specialist, Wragg also claimed that he was under stress after returning from the war in Iraq. He denied murdering Jacob, but pleaded guilty to manslaughter by reason of diminished capacity. Mrs Justice Anne Rafferty called the case "exceptional", gave Wragg a two-year prison sentence for manslaughter, then suspended his sentence for two years. Rafferty said  "nothing [was] to be gained" from sending Wragg to prison for the crime. See also
Hurler syndrome (MPS I)
Sanfilippo syndrome (MPS III)
Morquio syndrome (MPS IV)
Prenatal testing
Genetic counseling

References
External links
 Media related to Hunter syndrome at Wikimedia Commons
GeneReview/NIH/UW entry on Mucopolysaccharidosis Type II
History
Calcifications in the rotator cuff tendon were first described by Ernest Codman in his 1934 book The Shoulder. In 1952, in his study on x-ray therapy for people with such calcifications, Henry Plenk coined the term "calcifying tendinitis". References
External links
eMedicine on Calcific Tendonitis
Extracorporeal shock wave therapy (subscription required)