Individuals not taking MAOIs may consume at least 2 grams of tyramine in a meal and not experience an increase in blood pressure, whereas those taking MAOIs such as tranylcypromine may experience a sharp increase in blood pressure following consumption of as little as 10 mg of tyramine, which can lead to hypertensive crisis.Foods containing tyramine include aged cheeses, cured meats, tofu and certain red wines. Some, such as yeast extracts, contain enough tyramine to be potentially fatal in a single serving. Spoiled food is also likely to contain dangerous levels of tyramine. Adverse effects
Incidence of adverse effectsVery common (>10% incidence) adverse effects include:

Dizziness secondary to orthostatic hypotension (17%)Common (1-10% incidence) adverse effects include:

Tachycardia (5–10%)
Hypomania (7%)
Paresthesia (5%)
Weight loss (2%)
Confusion (2%)
Dry mouth (2%)
Sexual function disorders (2%)
Hypertension (1–2 hours after ingestion) (2%)
Rash (2%)
Urinary retention (2%)Other (unknown incidence) adverse effects include:

Increased/decreased appetite
Blood dyscrasias
Chest pain
Diarrhea
Edema
Hallucinations
Hyperreflexia
Insomnia
Jaundice
Leg cramps
Myalgia
Palpitations
Sensation of cold
Suicidal ideation
TremorOf note, there has not been found to be a correlation between sex and age below 65 regarding incidence of adverse effects.Tranylcypromine is not associated with weight gain and has a low risk for hepatotoxicity compared to the hydrazine MAOIs.It is generally recommended that MAOIs be discontinued prior to anesthesia; however, this creates a risk of recurrent depression. In a retrospective observational cohort study, patients on tranylcypromine undergoing general anesthesia had a lower incidence of intraoperative hypotension, while there was no difference between patients not taking an MAOI regarding intraoperative incidence of bradycardia, tachycardia, or hypertension.
Fibroma of tendon sheath is a benign tumor that presents as a small subcutaneous nodule that slowly increases in size. The tumors often have a multinodular growth pattern, with individual nodules being composed of bland, slender, spindle-shaped cells (myofibroblasts) in a dense, fibrous matrix.” A common microscopic finding is the presence of elongated, slit-like blood vessels. The lesions nearly always arise in the distal portions of the extremities. They often occur on the fingers, hands, toes, or feet. Although they are benign, they may recur in up to 40% of cases.Although they may be regarded as a tumor of the skin, the lesions arise from tendons and aponeuroses in superficial sites, and are therefore properly classified as in the category "soft tissue tumor." The World Health Organization, 2020, reclassified these tumors as a specific, benign tumor type in a broad category of soft tissue neoplasms termed fibroblastic and myofibroblastic tumors.The biological nature of Fibroma of tendon sheath is not known, but the category appears to comprise a number of different pathologic processes. It is considered that about one-third of the lesions in this category may be acral variants of the entity, nodular fasciitis. See also
Giant cell tumor of the tendon sheath
List of cutaneous conditions


== References ==