History
Itraconazole was approved for medical use in the United States in 1992.It was designated an orphan drug by both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). References
External links
 Media related to Itraconazole at Wikimedia Commons
"Itraconazole". Drug Information Portal. U.S. National Library of Medicine.
An interstitial pregnancy is a uterine but ectopic pregnancy; the pregnancy is located outside the uterine cavity in that part of the fallopian tube that penetrates the muscular layer of the uterus. The term cornual pregnancy is sometimes used as a synonym, but remains ambiguous as it is also applied to indicate the presence of a pregnancy located within the cavity in one of the two upper "horns" of a bicornuate uterus. Interstitial pregnancies have a higher mortality than ectopics in general. Anatomy
The part of the Fallopian tube that is located in the uterine wall and connects the remainder of the tube to the endometrial cavity is called its "interstitial" part, hence the term "interstitial pregnancy"; it has a length of 1–2 cm and a width of 0.7 cm. Its borders are the opening (ostium) of the tube to the endometrial cavity within the uterus and, laterally, the visible narrow segment of the tube. The area is well supplied by the Sampson artery which is connected to both the uterine and the ovarian arteries. Surrounded by uterine muscle (myometrium) it can expand significantly when it hosts a pregnancy. Interstitial pregnancies can be confused with angular pregnancies; the latter, however, are located within the endometrial cavity in the corner where the tube connects; typically those pregnancies are viable although a high rate of miscarriage has been reported. A pregnancy located next to the interstitial section laterally is an isthmic tubal pregnancy.