A 2016 paper examines Asperger syndrome as "an alternative pro-social adaptive strategy" which may have developed as a result of the emergence of "collaborative morality" in the context of small-scale hunter-gathering, i.e. where "a positive social reputation for making a contribution to group wellbeing and survival" becomes more important than complex social understanding.Conversely, some multidisciplinary research suggests that recent human evolution may be a driving force in the rise of a number of medical conditions in recent human populations, including autism. Studies in evolutionary medicine indicate that as biological evolution becomes outpaced by cultural evolution, disorders linked to bodily dysfunction increase in prevalence due to a lack of contact with pathogens and negative environmental conditions that once widely affected ancestral populations. Because natural selection primarily favors reproduction over health and longevity, the lack of this impetus to adapt to certain harmful circumstances creates a tendency for genes in descendant populations to over-express themselves, which may cause a wide array of maladies, ranging from mental illnesses to autoimmune disorders. Pathophysiology
Autisms symptoms result from maturation-related changes in various systems of the brain. How autism occurs is not well understood. Its mechanism can be divided into two areas: the pathophysiology of brain structures and processes associated with autism, and the neuropsychological linkages between brain structures and behaviors. The behaviors appear to have multiple pathophysiologies.There is evidence that gut–brain axis abnormalities may be involved. A 2015 review proposed that immune, gastrointestinal inflammation, malfunction of the autonomic nervous system, gut flora alterations, and food metabolites may cause brain neuroinflammation and dysfunction.
Washington D.C.: U.S. Centers for Disease Control and Prevention (CDC). ISBN 978-0990449119. Roush SW, Baldy LM, Hall MA, eds. (March 2019). "Chapter 16: Tetanus". Manual for the surveillance of vaccine-preventable diseases. Atlanta GA: U.S. Centers for Disease Control and Prevention (CDC). External links
"Tdap - Tetanus-Diphtheria-Pertussis Vaccine Information Statement". U.S. Centers for Disease Control and Prevention (CDC). 17 August 2021. "DTaP (Diphtheria, Tetanus, Pertussis) Vaccine Information Statement". U.S. Centers for Disease Control and Prevention (CDC). 17 August 2021. "DTaP/Tdap/Td ACIP Vaccine Recommendations". U.S. Centers for Disease Control and Prevention (CDC). 28 January 2020. Tetanus Toxoid at the US National Library of Medicine Medical Subject Headings (MeSH)
Diphtheria-Tetanus Vaccine at the US National Library of Medicine Medical Subject Headings (MeSH)
Diphtheria-Tetanus-Pertussis Vaccine at the US National Library of Medicine Medical Subject Headings (MeSH)
Diphtheria-Tetanus-acellular Pertussis Vaccines at the US National Library of Medicine Medical Subject Headings (MeSH)