Severe and chronic cases seldom respond sufficiently and require long periods of treatment which can increase the risk of side effects occurring. In individual cases, and especially in the case of atopic hand eczema, the dermatologist may prefer to use cortisone-free, anti-inflammatory creams or salves, which include calcineurin inhibitors tacrolimus or pimecrolimus. A 55 patient trial found topical bexarotene 1% gel monotherapy to be effective and well-tolerated (79% response rate for ≥50% clinical improvement; 39% response rate for ≥90% improvement). Phototherapy
Phototherapy can be effective in the treatment of chronic hand eczema. However, not all dermatologists or dermatology clinics offer this form of therapy, and it involves extended periods of treatment for the patient. A period of four to six weeks should involve 3–4 radiation sessions. The most frequently applied form of light therapy is PUVA therapy. This first treats the hands with a cream that contains an ingredient that causes the skin to become light-sensitive, the hands are then irradiated with ultraviolet A light  (UV-A). After two days of treatment, a pause of one day must occur. Due to possible risks such as premature skin aging or chronic light damage caused to the skin, phototherapy cannot be considered for the long term. Systemic treatment
Besides skin care, skin protection, and an external treatment, severe and chronic cases of hand eczema often also require systemic treatment. Various preparations are available for this. For acute, severe episodes exhibiting blister formation, internal cortisone preparations, sometimes in combination with certain antibiotics, may be helpful in the short term.
Pes (Latin for "foot") or the acronym PES may refer to:

Pes
Pes (unit), a Roman unit of length measurement roughly corresponding with a foot
Pes or podatus, a Neume § Neumes representing two notes
Pes (rural locality), several rural localities in Russia
Pes (river), a river in northwestern Russia
Pes (anatomy), zoological term for the distal portion of the hind limb of tetrapod animals
Talipes equinovarus (pes equinovarus), clubfoot
Talipes cavus (pes cavus), clawfoot
Talipes planus (pes planus), flat feet
Talipes valgus (pes valgus), valgus deformity of the foot
Talipes varus (pes varus), varus deformity of the foot
Pes anserinus (leg)
Pes anserine bursitis, inflammatory of the inner knee at the bursa of the pes anserinus
Parotid plexus, pes anserinus of the facial nerve

PES
Education
PES University, formerly P.E.S.