β2-selective agents
Butaxamine
ICI-118,551

β3-selective agents
SR 59230A

β1 selective antagonist and β3 agonist agents
Nebivolol

Comparative information
Pharmacological differences
Agents with intrinsic sympathomimetic action (ISA)
Acebutolol, pindolol, labetalol, mepindolol, oxprenolol, celiprolol, penbutolol
Agents organized by lipid solubility (lipophilicity)High lipophilicity: propranolol, labetalol
Intermediate lipophilicity: metoprolol, bisoprolol, carvedilol, acebutolol, timolol, pindolol
Low lipophilicity (also known as hydrophilic beta blockers): atenolol, nadolol, and sotalol
Agents with membrane stabilizing effectCarvedilol, propranolol > oxprenolol > labetalol, metoprolol, timolol

Indication differences
Agents specifically labeled for cardiac arrhythmia
Esmolol, sotalol, landiolol (Japan)
Agents specifically labeled for congestive heart failureBisoprolol, carvedilol, sustained-release metoprolol
Agents specifically labeled for glaucoma
Betaxolol, carteolol, levobunolol, timolol, metipranolol
Agents specifically labeled for myocardial infarctionAtenolol, metoprolol (immediate release), propranolol (immediate release), timolol, carvedilol (after left ventricular dysfunction), bisoprolol (preventive treatment before and primary treatment after heart attacks)
Agents specifically labeled for migraine prophylaxisTimolol, propranololPropranolol is the only agent indicated for the control of tremor, portal hypertension, and esophageal variceal bleeding, and used in conjunction with α-blocker therapy in phaeochromocytoma. Other effects
Beta blockers, due to their antagonism at beta-1 adrenergic receptors, inhibit both the synthesis of new melatonin and its secretion by the pineal gland. The neuropsychiatric side effects of some beta blockers (e.g. sleep disruption, insomnia) may be due to this effect.Some pre-clinical and clinical research suggests that some beta blockers may be beneficial for cancer treatment. However, other studies do not show a correlation between cancer survival and beta blocker usage. Also, a 2017 meta-analysis failed to show any benefit for the use of beta blockers in breast cancer.Beta blockers have also been used for the treatment of schizoid personality disorder.
A blister is a small pocket of body fluid (lymph, serum, plasma, blood, or pus) within the upper layers of the skin, usually caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection. Most blisters are filled with a clear fluid, either serum or plasma. However, blisters can be filled with blood (known as "blood blisters") or with pus (for instance, if they become infected). The word "blister" entered English in the 14th century. It came from the Middle Dutch bluyster and was a modification of the Old French blostre, which meant a leprous nodule—a rise in the skin due to leprosy. In dermatology today, the words vesicle and bulla refer to blisters of smaller or greater size, respectively. To heal properly, a blister should not be popped unless medically necessary. If popped, the excess skin should not be removed because the skin underneath needs the top layer to heal properly. Causes
A blister may form when the skin has been damaged by friction or rubbing, heat, cold or chemical exposure. Fluid collects between the upper layers of skin (the epidermis) and the layers below (the dermis). This fluid cushions the tissue underneath, protecting it from further damage and allowing it to heal. Friction
Intense rubbing can cause a blister, as can any friction on the skin if continued long enough. This kind of blister is most common after walking long distances or by wearing old or poorly fitting shoes.