The drug is contraindicated when co-administered with certain drugs, such as drugs dependent on CYP3A for removal, for which a raised concentration results in serious reactions, or those with potent CYP3A inducers, for which reduced blood concentration of the two main components may result in loss of effect against the virus and possible resistance, among others. Co-administration also affects the concentration of several drugs, sometimes requiring changing the dose or careful monitoring. Many of these drugs are widely prescribed to people at high risk from COVID-19. With the extension of the emergency authorization in August 2022, the FDA updated a checklist to help evaluate potential drug interactions and other patient factors before prescribing Paxlovid, including more than 120 drugs which are either contraindicated, should be avoided or held from use, or require dose adjustments or special monitoring.Adverse events of the co-packaged medication, regardless of causality, observed in the phase II-III EPIC-HR study included: dysgeusia (4.8–6%), diarrhea (3–3.9%), vomiting (1.3%), hypertension (1%), and myalgia (1%).There is no specific antidote for overdose with the co-packaged medication. Treatment consists of supportive measures such as monitoring of vital signs and observation of clinical status. Rebound
An additional analysis of the original EPIC-HR clinical trial data (Delta variant) showed that about 2% of both the treatment and placebo groups experienced a symptomatic rebound after the 5 day treatment, meaning they felt ill again and tested positive again (antigen test and PCR test) after testing negative. This is important, because people with rebound cannot go back to work or school.
Penile pain refers to pain in the penis, human or otherwise. Common causes
Penile injury
Circumcision
Penile fracture
Priapism
Phimosis
Peyronies disease
Sexually transmitted infections
Chronic prostatitis/chronic pelvic pain syndrome

Cultural references
Priapus, a minor Greek god of fertility, is marked by his oversized, permanent erection, which gave rise to the medical term priapism. Some researchers believe the depiction of Priapus penis referred to a penile disease, and that paintings of Priapus were used to ward off the disease. See also
Genital pain
Vaginal pain
Testicular pain
List of the causes of genital pain


== References ==