This, as far as we know, is best achieved by providing a relationship between husband and wife exemplifying these respective roles. "In 1968, Green published "Childhood Cross-Gender Identification", a paper reviewing the therapy of nine AMAB children who were younger than 8 and "clearly prepubertal". The first six were from the collaborative papers between Green and Money, the last 3 were from Robert Stoller. Citing the failure of attempts to "cure" adult trans women, he reported early diagnosis and treatment may be effective in preventing manifestations of adulthood cross-gender identification. The stated goals of family therapy are for "for the husband and wife to gain some perspective on the second class citizen of the husband and of the significance of their unbalanced roles in shaping their sons personality. Additional focus is on the masculinity-inhibiting of mothers anxiety over her sons healthy aggression and her greater comfort with what to her is his less threatening behavior. "Another early researcher was George Alan Rekers, who later became an administrator at NARTH, who focused his 1972 doctoral research on the treatment of feminine boys. In this work, Rekers describes a litany of feminine behaviours which he catalogues including: feminine posture, gait, arm and hand gestures, feminine inflection in speech, as well as interest in feminine clothing, games and conversation topics.
In exogenous ochronosis, the hyperpigmentation is localized to the area where the inciting agent is applied. Intradermal nevi can appear like blue nevi. Eye: Ocular manifestations are frequent in patients with ochronosis; most commonly hyperpigmentation of the sclera, primarily observed symmetrically to both sides of the cornea within the palpebral fissure. Furthermore, brown pigment spots in the limbus are generally considered pathognomonic. These ocular signs generally occur early in the development of the disease and can serve as a valuable diagnostic feature of the disease. Cartilage: Darkening and hardening of ear cartilage is a prominent feature of ochronosis. Nasal cartilage is also frequently involved. The voice can be affected by hardening of the laryngeal cartilage. Stiffening of the ribs with decreased lung function has also been reported. The intervertebral cartilage is also more prone to herniation. Connective tissue: Hardening of tendons and ligaments can predispose them to rupture. Color changes in the joints can be observed clinically. Arthropathy is common due to chronic inflammation and microruptures. Heart valves: Stenosis can results from the increased rigidity of the connective tissue as well as chronic inflammation.Symptoms of exogenous ochronosis  include:
Yellow-brown, banana-shaped fibers
Caviar-like papules
Brown-grey or blue-black hyperpigmentationMost of the lesions are seen on areas of the body that get the most sun. Causes
Exogenous ochronosis can be caused from long-term use of certain "skin-lightening" products, even if the hydroquinone is in amounts as small as 2%. Skin-lightening products are still prevalent in many parts of the world.