While it has been shown that a single dose does not significantly alter either maternal or fetal circulation, this subject has not been studied extensively enough to draw reliable conclusions. Overdose
If accidentally ingested, standard methods to remove unabsorbed drugs should be considered. There is no specific antidote for oxymetazoline, although its pharmacological effects may be reversed by an adrenergic antagonists such as phentolamine. In the event of a possibly life-threatening overdose (such as a hypertensive crisis), benzodiazepines should be considered to decrease the likelihood of seizures and convulsions, as well as reduce anxiety and to lower blood pressure. In children, oxymetazoline may produce profound central nervous system depression due to stimulation of central α2 receptors and imidazoline receptors, much like clonidine. Pharmacology
Pharmacodynamics
Oxymetazoline is a sympathomimetic that selectively agonizes α1 and, partially, α2 adrenergic receptors. Since vascular beds widely express α1 receptors, the action of oxymetazoline results in vasoconstriction. In addition, the local application of the drug also results in vasoconstriction due to its action on endothelial postsynaptic α2 receptors; systemic application of α2 agonists, in contrast, causes vasodilation because of centrally-mediated inhibition of sympathetic tone via presynaptic α2 receptors. Vasoconstriction of vessels results in relief of nasal congestion in two ways: first, it increases the diameter of the airway lumen; second, it reduces fluid exudation from postcapillary venules. It can reduce nasal airway resistance (NAR) up to 35.7% and reduce nasal mucosal blood flow up to 50%.
The German TV series Dr. Stefan Frank episode "Ein himmlisches Lächeln" (season 4, episode 4) is about a young boy living with Möbius syndrome. The book "Secret Weapon" of the Alex Rider series gives a mention to Darcus Drake, a man with Möbius syndrome. In “The Adventure of the Man Who Never Laughed”, a story written by John H. Watson, M.D./discovered by J. N. Williamson, and collected in Holmes For The Holidays, edited by Martin H. Greenberg, Jon L. Lellenberg and Carol-Lynn Waugh (Berkley Prime Crime, 1996), a missing person has Möbius syndrome. References
External links

Möbius syndrome at Curlie
Möbius syndrome at the National Institute of Neurological Disorders and Stroke