These AT domains are the only domains present on MmpC, while the other three type I PKS proteins contain no AT domains. The mupirocin pathway also contains several tandem acyl carrier protein doublets or triplets. This may be an adaptation to increase the throughput rate or to bind multiple substrates simultaneously.Pseudomonic acid A is the product of an esterification between the 17C polyketide monic acid and the 9C fatty acid 9-hydroxy-nonanoic acid. The possibility that the entire molecule is assembled as a single polyketide with a Baeyer-Villiger oxidation inserting an oxygen into the carbon backbone has been ruled out because C1 of monic acid and C9 of 9-hydroxy-nonanoic acid are both derived from C1 of acetate. Monic acid biosynthesis
Biosynthesis of the 17C monic acid unit begins on MmpD (Figure 1). One of the AT domains from MmpC may transfer an activated acetyl group from acetyl-Coenzyme A (CoA) to the first ACP domain. The chain is extended by malonyl-CoA, followed by a SAM-dependent methylation at C12 (see Figure 2 for PA-A numbering) and reduction of the B-keto group to an alcohol. The dehydration (DH) domain in module 1 is predicted to be non-functional due to a mutation in the conserved active site region. Module 2 adds another two carbons by the malonyl-CoA extender unit, followed by ketoreduction (KR) and dehydration. Module three adds a malonyl-CoA extender unit, followed by SAM-dependent methylation at C8, ketoreduction, and dehydration. Module 4 extends the molecule with a malonyl-CoA unit followed by ketoreduction.
An arthropathy is a disease of a joint. Types
Arthritis is a form of arthropathy that involves inflammation of one or more joints, while the term arthropathy may be used regardless of whether there is inflammation or not. Joint diseases can be classified as follows:

ArthritisInfectious arthritisSeptic arthritis (infectious)
Tuberculosis arthritis
Reactive arthritis (indirectly)Noninfectious arthritisSeronegative spondyloarthropathy:Psoriatic arthritis
Ankylosing spondylitisRheumatoid arthritis:Feltys syndromeJuvenile idiopathic arthritis
Adult-onset Stills disease
Crystal arthropathyGout
ChondrocalcinosisOsteoarthritisHemarthrosis (joint bleeding)
Synovitis is the medical term for inflammation of the synovial membrane. Joint dislocation

With arthropathy in the name
Reactive arthropathy (M02-M03) is caused by an infection, but not a direct infection of the synovial space. (See also Reactive arthritis)
Enteropathic arthropathy (M07) is caused by colitis and related conditions. Crystal arthropathy (also known as crystal arthritis) (M10-M11) involves the deposition of crystals in the joint. In gout, the crystal is uric acid. In pseudogout/chondrocalcinosis/calcium pyrophosphate deposition disease, the crystal is calcium pyrophosphate. Diabetic arthropathy (M14.2, E10-E14) is caused by diabetes. Neuropathic arthropathy (M14.6) is associated with a loss of sensation.Spondylarthropathy is any form of arthropathy of the vertebral column. Signs and symptoms
Joint pain is a common but non-specific sign of joint disease. Signs will depend on the specific disease, and may even then vary. Common signs may include:
Decreased range of motion
Stiffness
Effusion
Pneumarthrosis, air in a joint (which is also a common normal finding). Bone erosion
Systemic signs of arthritis such as fatigue

Diagnosis
Diagnosis may be a combination of medical history, physical examination, blood tests and medical imaging (generally X-ray initially). Treatment
References


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