A series of perforator veins interconnect the superficial and deep systems. In the standing posture, the veins of the leg have to handle an exceptional load as they act against gravity when they return the blood to the heart. The venous valves assist in maintaining the superficial to deep direction of the blood flow.Superficial veins:

Great saphenous vein
Small saphenousDeep veins:

Femoral vein, whose segments are the common femoral vein and the subsartorial vein. Popliteal vein
Anterior tibial vein
Posterior tibial vein
Fibular vein

Nerve supply
The sensory and motor innervation to the lower limb is supplied by the lumbosacral plexus, which is formed by the ventral rami of the lumbar and sacral spinal nerves with additional contributions from the subcostal nerve (T12) and coccygeal nerve (Co1). Based on distribution and topography, the lumbosacral plexus is subdivided into the lumbar plexus (T12-L4) and the Sacral plexus (L5-S4); the latter is often further subdivided into the sciatic and pudendal plexuses:The lumbar plexus is formed lateral to the intervertebral foramina by the ventral rami of the first four lumbar spinal nerves (L1-L4), which all pass through psoas major. The larger branches of the plexus exit the muscle to pass sharply downward to reach the abdominal wall and the thigh (under the inguinal ligament); with the exception of the obturator nerve which pass through the lesser pelvis to reach the medial part of the thigh through the obturator foramen.
While the capacity to walk upright is not unique to humans, other primates can only achieve this for short periods and at a great expenditure of energy.The human adaption to bipedalism has also affected the location of the bodys center of gravity, the reorganization of internal organs, and the form and biomechanism of the trunk. In humans, the double S-shaped vertebral column acts as a great shock-absorber which shifts the weight from the trunk over the load-bearing surface of the feet. The human legs are exceptionally long and powerful as a result of their exclusive specialization for support and locomotion—in orangutans the leg length is 111% of the trunk; in chimpanzees 128%, and in humans 171%. Many of the legs muscles are also adapted to bipedalism, most substantially the gluteal muscles, the extensors of the knee joint, and the calf muscles. Skeleton
The major bones of the leg are the femur (thigh bone), tibia (shin bone), and adjacent fibula, and these are all long bones. The patella (kneecap) is the sesamoid bone in front of the knee. Most of the leg skeleton has bony prominences and margins that can be palpated and some serve as anatomical landmarks that define the extent of the leg. These landmarks are the anterior superior iliac spine, the greater trochanter, the superior margin of the medial condyle of tibia, and the medial malleolus. Notable exceptions to palpation are the hip joint, and the neck and body, or shaft of the femur.