During labor and delivery cardiac output increases more in part due to the associated anxiety and pain, as well as due to uterine contractions which will cause an increase in systolic and diastolic blood pressure.Valvular heart lesions associated with high maternal and fetal risk during pregnancy include:
Severe aortic stenosis with or without symptoms
Aortic regurgitation with NYHA functional class III-IV symptoms
Mitral stenosis with NYHA functional class II-IV symptoms
Mitral regurgitation with NYHA functional class III-IV symptoms
Aortic and/or mitral valve disease resulting in severe pulmonary hypertension (pulmonary pressure greater than 75% of systemic pressures)
Aortic and/or mitral valve disease with severe LV dysfunction (EF less than 0.40)
Mechanical prosthetic valve requiring anticoagulation
Marfan syndrome with or without aortic regurgitationIn individuals who require an artificial heart valve, consideration must be made for deterioration of the valve over time (for bioprosthetic valves) versus the risks of blood clotting in pregnancy with mechanical valves with the resultant need of drugs in pregnancy in the form of anticoagulation. == References ==
Sodium nitrite/sodium thiosulfate, sold under the brand name Nithiodote, is a fixed-dose combination medication used as an antidote for cyanide poisoning. It contains sodium thiosulfate and sodium nitrite. It is given by intravenous infusion into a vein.It was approved for medical use in the United States in January 2011. Medical uses
Sodium nitrite/sodium thiosulfate is indicated for the treatment of acute cyanide poisoning. See also
Sodium nitrite
Sodium thiosulfate

References
External links
"Sodium nitrite mixture with sodium thiosulfate". Drug Information Portal. U.S. National Library of Medicine.