Prophylaxis should be continued for the patients lifetime unless multiple drug therapy for MAC becomes necessary because of the development of MAC disease.Clinicians must weigh the potential benefits of MAC prophylaxis against the potential for toxicities and drug interactions, the cost, the potential to produce resistance in a community with a high rate of tuberculosis, and the possibility that the addition of another drug to the medical regimen may adversely affect patients compliance with treatment. Because of these concerns, therefore, in some situations rifabutin prophylaxis should not be administered.Before prophylaxis is administered, patients should be assessed to ensure that they do not have the active disease due to MAC, M. tuberculosis, or any other mycobacterial species. This assessment may include a chest radiograph and tuberculin skin test.Rifabutin, by mouth daily, is recommended for the peoples lifetime unless disseminated MAC develops, which would then require multiple drug therapy. Although other drugs, such as azithromycin and clarithromycin, have laboratory and clinical activity against MAC, none has been shown in a prospective, controlled trial to be effective and safe for prophylaxis. Thus, in the absence of data, no other regimen can be recommended at this time. The 300-mg dose of rifabutin has been well tolerated. Adverse effects included neutropenia, thrombocytopenia, rash, and gastrointestinal disturbances. Treatment
Postinfection treatment involves a combination of antituberculosis antibiotics, including rifampicin, rifabutin, ciprofloxacin, amikacin, ethambutol, streptomycin, clarithromycin or azithromycin.NTM infections are usually treated with a three-drug regimen of either clarithromycin or azithromycin, plus rifampicin and ethambutol.
During the Reign of Terror, which began in July 1793 and lasted thirteen months, Paris was governed by the Committee of Public Safety who oversaw a regime of mass executions and public purges.Prior to the French Revolution, ancient philosophers wrote about tyrannicide, as tyranny was seen as the greatest political threat to Greco-Roman civilization. Medieval philosophers were similarly occupied with the concept of tyranny, though the analysis of some theologians like Thomas Aquinas drew a distinction between usurpers, who could be killed by anyone, and legitimate rulers who abused their power—the latter, in Aquinas view, could only be punished by a public authority. John of Salisbury was the first medieval Christian scholar to defend tyrannicide. Most scholars today trace the origins of the modern tactic of terrorism to the Jewish Sicarii Zealots who attacked Romans and Jews in 1st-century Palestine. They follow its development from the Persian Order of Assassins through to 19th-century anarchists. The "Reign of Terror" is usually regarded as an issue of etymology. The term terrorism has generally been used to describe violence by non-state actors rather than government violence since the 19th-century Anarchist Movement.In December 1795, Edmund Burke used the word "Terrorists" in a description of the new French government called Directory:
At length, after a terrible struggle, the [Directory] Troops prevailed over the Citizens ... To secure them further, they have a strong corps of irregulars, ready armed.