In HS, the erythrocytes fail to pass through fenestrations, and this is where resident splenic macrophages sample, or "bite," part of the stuck spherocytes plasma membranes. The macrophages recognize that the spherocyte is not normal, and the macrophage is "programmed" to destroy irregularities filtered at the spleen from the blood. The resident splenic macrophages therefore phagocytose the spherocytes, causing extravascular hemolysis. This leads to both splenomegaly and anemia. Should this process continue unchecked chronically, inappropriate regulation of erythropoeisis leads to extramedullary hematopoiesis. Clinical Presentation
HS patients present in a vast array of presentations from being asymptomatic, to the extreme situations of splenic rupture and/or hemolytic crisis, or in-utero demise. Asymptomatic HS (mild): 20-30% of patients. Infantile-Onset HS (moderate): 60-75% of patients. Neonatal or In-Utero Onset HS (severe): <5% of patients.The most common presentation will demonstrate jaundice (due to increased unconjugated bilirubin), anemia (with secondary pallor), and a palpable spleen sometimes with concomitant tenderness (due to splenic congestion and splenomegaly). Its worth noting that a subsection of HS patients will also have incidental black pigmented gallstones (made of calcium bilirubinate consequence of the extravascular hemolysis), and some of these patients will develop cholelithiasis and/or the potential complex sequelae of this condition, i.e. cholecystisis, choledocholithiasis, etc. Diagnostics
Laboratory Testing
Available lab testing that may aid in the diagnosis of HS is as follows:

Coombs Test
Osmotic Fragility Test
Acidified Glycerol Lysis Test
Supportive blood work: mean cell volume (MCV), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), red blood cell count (RBC), reticulocytes, unconjugated bilirubin, haptoglobin, lactate dehydrogenase (LDH).
Yasmin, Yasmine or Yasmina may refer to:

Yasmin (given name), a common female nameYasmin - Jasmine Flower

Yasmin (musician), a female British DJ and singer-songwriter
Yasmine (singer), a female Belgian singer, presenter and television personality. Yasmin (drug), marketing name of a birth control pill
Yasmin, a doll in the Bratz fashion doll line

Film and television
Yasmin (1955 film), a 1955 Hindi film directed by Abdur Rashid Kardar and starring Vyjayanthimala
Yasmin (2004 film), a 2004 English film directed by Kenneth Glenaan and starring Archie Panjabi
Yasmine (film), a 2014 Bruneian film
Yasmins Getting Married, an Australian reality television show
Yasmina (film), a 1927 French silent film

See also
Jasmin (disambiguation)
Jasmine (disambiguation)
Yasemin (disambiguation)