Plague or The Plague may refer to:

Agriculture, fauna, and medicine
Plague (disease), a disease caused by Yersinia pestis
An epidemic of infectious disease (medical or agricultural)
A pandemic caused by such a disease
A swarm of pest insects such as locusts
A massive attack of other pests afflicting agriculture
Overpopulation in wild animals afflicting the environment and/or agriculture
Plague, collective noun for common grackles

Historical plagues
List of epidemics
Antonine Plague, an ancient pandemic in 165–189 CE brought to the Roman Empire by troops returning from campaigns in the Near East
Black Death, the Eurasian pandemic beginning in the 14th century
Great Northern War plague outbreak, a European outbreak in the early 18th century
Great Plague of London, a massive outbreak in England that killed an estimated 20% of Londons population in 1665–1666
Plague of Athens, a devastating epidemic which hit Athens in ancient Greece in 430 BCE
Plague of Justinian, a pandemic in 541–542 CE in the Byzantine Empire
Plague Riot, a riot in Moscow in 1771 caused by an outbreak of bubonic plague

Modern plagues
Third plague pandemic or Third Plague, a major plague pandemic that began in China in 1855 until 1960
Manchurian plague (1910–11): Part of the third plague pandemic
HIV/AIDS, originally referred to as the "gay plague" when it was discovered in the 1980s (see History of HIV/AIDS)

Art, media, and entertainment
Art
Plague (painting), by Arnold Böcklin

Fictional entities
Plague, Lisbeth Salanders hacker friend and colleague in the Hacker Republic, e.g., see The Girl who Kicked the Hornets Nest#Trial
The Plague (G.I. Joe), a Cobra special forces team in the comic book G.I.
These mutations are not specific to myelofibrosis, and are linked to other myeloproliferative neoplasms, specifically polycythemia vera and essential thrombocythemia.The V617F mutation to the JAK2 protein is found in approximately half of individuals with primary myelofibrosis. The V617F mutation is a change of valine to phenylalanine at the 617 position. Janus kinases (JAKs) are non-receptor tyrosine kinases essential for the activation of signaling that is mediated by cytokine receptors lacking catalytic activity. These include receptors for erythropoietin, thrombopoietin, most interleukins and interferon. JAK2 mutations are significant because JAK2 plays a role in controlling production of blood cells from hematopoietic stem cells. The V617F mutation appears to make hematopoietic cells more sensitive to growth factors that need JAK2 for signal transduction, which include erythropoietin and thrombopoietin.The MPL gene codes for a protein that acts as a receptor for thrombopoietin. A mutation in that gene, known as a W515 mutation, leads to the production of an abnormal thrombopoietin receptor protein, which results in the overproduction of abnormal megakaryocytes. The abnormal megakaryocytes stimulate other cells, the fibroblasts, to produce collagen in the bone marrow, by secreting PDGF and TGF-β1. Mechanism
Myelofibrosis is a clonal neoplastic disorder of hematopoiesis, the formation of blood cellular components. It is one of the myeloproliferative disorders, diseases of the bone marrow in which excess cells are produced at some stage. Production of cytokines such as fibroblast growth factor by the abnormal hematopoietic cell clone (particularly by megakaryocytes) leads to replacement of the hematopoietic tissue of the bone marrow by connective tissue via collagen fibrosis.