Attempts to understand and manage the mechanisms at work in floodplains have been made for at least six millennia.In the United States, the Association of State Floodplain Managers works to promote education, policies, and activities that mitigate current and future losses, costs, and human suffering caused by flooding and to protect the natural and beneficial functions of floodplains – all without causing adverse impacts. A portfolio of best practice examples for disaster mitigation in the United States is available from the Federal Emergency Management Agency. Control
In many countries around the world, waterways prone to floods are often carefully managed. Defenses such as detention basins, levees, bunds, reservoirs, and weirs are used to prevent waterways from overflowing their banks. When these defenses fail, emergency measures such as sandbags or portable inflatable tubes are often used to try to stem flooding. Coastal flooding has been addressed in portions of Europe and the Americas with coastal defenses, such as sea walls, beach nourishment, and barrier islands. In the riparian zone near rivers and streams, erosion control measures can be taken to try to slow down or reverse the natural forces that cause many waterways to meander over long periods of time. Flood controls, such as dams, can be built and maintained over time to try to reduce the occurrence and severity of floods as well. In the United States, the U.S. Army Corps of Engineers maintains a network of such flood control dams.
However, Staphylococcus aureus, coagulase-negative staphylococci and enterococci are resistant.It is also used to treat typhoid fever. Spectrum of bacterial susceptibility
Cefixime is a broad spectrum cephalosporin antibiotic and is commonly used to treat bacterial infections of the ear, urinary tract, and upper respiratory tract. The following represents MIC susceptibility data for a few medically significant microorganisms:
Escherichia coli: 0.015 µg/mL – 4 µg/mL
Haemophilus influenzae: ≤0.004 µg/mL – >4 µg/mL
Proteus mirabilis: ≤0.008 µg/mL – 0.06 µg/mL
Streptococcus pneumoniae: 0.12 µg/mL 
Staphylococcus aureus: >128 µg/mL (Resistant)
Enterobacter spp. : >128 µg/mL (Resistant)

Mechanism of action
The bactericidal action of Cefixime is due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption
Only 40–50% is absorbed from the GI tract (oral bioavailability). Absorption may be slowed but not decreased when taken with food. Average peak concentration after administration of oral suspension is approximately 25–50% greater than the peak concentration following oral tablet or capsules administration.Distribution
It has high concentrations in bile and urine. It can cross the placenta and its protein binding capacity is 65%.It is always better to perform appropriate cultures and susceptibility studies to determine the causative organism and its sensitivity to cefixime. Contraindications
Cefixime is contraindicated in patients with known sensitivity or allergies to cephalosporin class of antibiotics. As Cefixime is a third generation cephalosporin, it is not contraindicated for patients with a true penicillin allergy.