The royal or princely attribute comes in on the occasion of their relationship to the Mughal Imperial (Amir) and Afghan Royal family (Sardar). The Imam of Naqshbandi Sunni Islam, who is known for bearing this title is customarily addressed as "His Serene Highness Prince Sayyid" Raphael Dakik, who is a member of the Afghan Royal Family and paternal and maternal descendant of Hazrat Ishaan from the family of Sayyid Mir Jan in the 12th generation. Maternal descendance
According to Irans religious leader and the Deobandi creed—a creed especially followed by patriarchal Pashtun tribes—the status of being a Sayyid can only be attributed through patrilineal lineage. According to Shia opinions, children of a Sayyida mother and a non-Sayyid father are referred to as Mirza. The Persian notation "Mirza", which is a derivation of the word "Mirzada" (i.e., Son of a "Mir") has various meanings: one is a Sayyid leader of a Sayyid branch or community, simultaneously being a religious Islamic scholar. Thus, a Sayyid of patrilineal lineage, being the son of a Mir, can also be called "Mirza". This example substantiates the fact that there are different opinions concerning the transmission of the title Sayyid. Another historical opinion of Ottoman Naqib al Ashrafs expresses that children of maternal prophetical descent are called Sharif. : 131 However, in 1632 when an Ottoman court challenged a man wearing a Sayyids green turban, he established that he was a Sayyid on his mothers side, which was accepted by the court. : 130 In patriarchal societies, women usually have to assimilate themselves into their husbands status.
In females, where plasma VLCFA measurement is not always conclusive (some female carriers will have normal VLCFA in plasma), molecular analysis is preferred, particularly in cases where the mutation in the family is known. Although the clinical phenotype is highly variable among affected males, the elevations of VLCFA are present in all males with an ABCD1 mutation.Because the characteristic elevations associated with ALD are present at birth, well before any symptoms are apparent, there have been methods developed in the interests of including it in newborn screening programs. One of the difficulties with ALD as a disease included in universal newborn screening is the difficulty in predicting the eventual phenotype that an individual will express. The accepted treatment for affected boys presenting with the cerebral childhood form of the disease is a bone marrow transplant, a procedure which carries significant risks. However, because most affected males will demonstrate adrenal insufficiency, early discovery and treatment of this symptom could potentially prevent complications and allow these patients to be monitored for other treatment in the future, depending on the progression of their disease.The Loes score is a rating of the severity of abnormalities in the brain found on MRI. It ranges from 0 to 34, based on a point system derived from the location and extent of disease and the presence of atrophy in the brain, either localized to specific points or generally throughout the brain. A Loes score of 0.5 or less is classified as normal, while a Loes score of 14 or greater is considered severe.