Artificial systems inherently have a major defect: they must be premised on one or more fundamental assumptions upon which additional knowledge is built. This is in strict alignment to the Gödels incompleteness theorems. The Artificial system can be defined as a "consistent formalized system which contains elementary arithmetic". These fundamental assumptions are not inherently deleterious, but they must by definition be assumed as true, and if they are actually false then the system is not as structurally integral as is assumed (i.e. it is evident that if the initial expession is false, then the Artificial system is not a "consistent formalized system"). For example, in geometry this is very evident in the postulation of theorems and extrapolation of proofs from them. George J. Klir maintained that no "classification is complete and perfect for all purposes", and defined systems as abstract, real, and conceptual physical systems, bounded and unbounded systems, discrete to continuous, pulse to hybrid systems, etc. The interactions between systems and their environments are categorized as relatively closed and open systems. It seems most unlikely that an absolutely closed system can exist or, if it did, that it could be known by man.
Short-limb skeletal dysplasia with severe combined immunodeficiency is an extremely rare autosomal recessive type of achondroplasia which is characterized by short stature,  bowing of the long bones, and generalized metaphyseal abnormalities alongside signs of SCID such as recurrent severe infections, failure to thrive, chronic diarrhea, and a notable absence of T and B lymphocytes. Around 11 cases have been described in medical literature. == References ==