Further reading
Gliebus, G. (March 2010). "Primary progressive aphasia: clinical, imaging, and neuropathological findings". Am J Alzheimers Dis Other Demen. 25 (2): 125–7. doi:10.1177/1533317509356691. PMID 20124255. S2CID 29195502. Henry, M.L. ; Beeson, P.M.; Rapcsak, S.Z. (February 2008). "Treatment for anomia in semantic dementia". Semin Speech Lang. 29 (1): 60–70. doi:10.1055/s-2008-1061625. PMC 2699352. PMID 18348092. Henry, M.L. ; Gorno-Tempini, M.L. (December 2010). "The logopenic variant of primary progressive aphasia". Current Opinion in Neurology. 23 (6): 633–7. doi:10.1097/WCO.0b013e32833fb93e. PMC 3201824. PMID 20852419. Reilly, J.; Rodriguez, A.D.; Lamy, M.; Neils-Strunjas, J. (2010). "Cognition, language, and clinical pathological features of non-Alzheimers dementias: an overview". J Commun Disord. 43 (5): 438–52. doi:10.1016/j.jcomdis.2010.04.011. PMC 2922444. PMID 20493496. Rohrer, J.D. ; Knight, W.D. ; Warren, J.E. ; Fox, N.C.; Rossor, M.N. ; Warren, J.D. (January 2008). "Word-finding difficulty: a clinical analysis of the progressive aphasias". Brain. 131 (Pt 1): 8–38. doi:10.1093/brain/awm251. PMC 2373641. PMID 17947337. == External links ==
Dornase alfa (proprietary name Pulmozyme from Genentech) is a highly purified solution of recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Dornase alfa hydrolyzes the DNA present in sputum/mucus of cystic fibrosis patients and reduces viscosity in the lungs, promoting improved clearance of secretions. This protein therapeutic agent is produced in Chinese hamster ovary cells. Cystic fibrosis
Dornase alfa is the most recent therapeutic agent developed with this basic mechanism of action. Prior to the cloning of the human enzyme, bovine DNase I was on the market for many years, though its utility was limited by the inherent antigenic response to a cow protein in the lungs of patients. Other DNases, such as DNase II, have therapeutic potential as well, but no further DNases have been brought to market yet for cystic fibrosis. Dornase alfa is an orphan drug. Contraindications
Hypersensitivity to dornase alfa
Hypersensitivity to Chinese hamster ovary cell products

Economy
Dornase alpha 1000 units (1 mg/ml)2.5ml (2500units) = £18.52 (GBP)

Off label use
Dornase alfa has recently been shown to improve lung function in non-cystic fibrosis pre-term infants atelectasis where other therapies have failed.In studies conducted, Dornase alfa has been thought to help resolve mucus secretion in COVID-19 patients as well as in the treatment of cystic fibrosis, but since it is taken with nebulizer in general use and there is a possibility of aerosolization of the virus, it is not preferred in most medical centers to avoid secondary infections. == References ==