A positive wrist sign is where the little finger and the thumb overlap, caused by a combination of thin wrists and long fingers. Differential diagnosis
Many other disorders can produce the same type of body characteristics as Marfan syndrome. Genetic testing and evaluating other signs and symptoms can help to differentiate these. The following are some of the disorders that can manifest as "marfanoid":
Congenital contractural arachnodactyly, also known as Beals-Hecht syndrome
Ehlers–Danlos syndrome
Homocystinuria
Loeys–Dietz syndrome
MASS phenotype
Multiple endocrine neoplasia, type 2B
Shprintzen–Goldberg syndrome
Stickler syndrome

Management
There is no cure for Marfan syndrome, but life expectancy has increased significantly over the last few decades and is now similar to that of the average person.Regular checkups are recommended to monitor the health of the heart valves and the aorta. Marfan syndrome is treated by addressing each issue as it arises and, in particular, preventive medication even for young children to slow progression of aortic dilation. The goal of this treatment strategy is to slow the progression of aortic dilation and prevent any damage to heart valves by eliminating heart arrythmias, minimizing the heart rate, and lowering the persons blood pressure. Physical activity
The American Heart Association made the following recommendations for people with Marfan syndrome with no or mild aortic dilation:
Probably permissible activities: bowling, golf, skating (but not ice hockey), snorkeling, brisk walking, treadmill, stationary biking, modest hiking, and tennis (doubles and singles). Intermediate risk: basketball (both full- and half-court), racquetball, squash, running (sprinting and jogging), skiing (downhill and cross-country), soccer, touch (flag) football, baseball, softball, biking, lap swimming, motorcycling, and horseback riding.
In medicine, granulocytosis is the presence of an increased number of granulocytes in the peripheral blood. Often, the word refers to an increased neutrophil granulocyte count (neutrophilia), but granulocytosis formally refers to the combination of neutrophilia, eosinophilia, and basophilia. Leukocytosis refers to an increase in the number of all white blood cells. Causes
Granulocytosis can be a feature of a number of diseases, including:
Infection, especially bacterial
Malignancy, most notably leukemia (it is the main feature of chronic myelogenous leukemia, CML)
Autoimmune disease

Diagnosis
Diagnosis of granulocytosis is usually done by obtaining a complete blood count. Prognostic
In cardiovascular disease, increased white blood cell counts have been shown to indicate a worse prognosis. See also
Agranulocytosis
Bandemia
Complete blood count

References


== External links ==