Other soluble mediators of fibrosis include CTGF, platelet-derived growth factor (PDGF), and interleukin 10 (IL-10). These initiate signal transduction pathways such as the AKT/mTOR and SMAD  pathways that ultimately lead to the proliferation and activation of fibroblasts, which deposit extracellular matrix into the surrounding connective tissue. This process of tissue repair is a complex one, with tight regulation of extracellular matrix (ECM) synthesis and degradation ensuring maintenance of normal tissue architecture. However, the entire process, although necessary,  can lead to a progressive irreversible fibrotic response if tissue injury is severe or repetitive, or if the wound healing response itself becomes deregulated. Anatomical location
Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include:

Lungs
Fibrothorax
Pulmonary fibrosis
Cystic fibrosis
Idiopathic pulmonary fibrosis (idiopathic meaning the cause is unknown)
Radiation-induced lung injury (following treatment for cancer)

Liver
Bridging fibrosis An advanced stage of liver fibrosis seen in the progressive form of chronic liver diseases. The term “bridging” means ‘the formation of “bridge” (by the band of mature & thick fibrous tissue) obliterating portal area to central vein’, leads to the formation of pseudolobules. Long-term exposure to hepatotoxin (e.g. thioacetamide, carbon tetrachloride, diethylnitrosamine) results in the bridging fibrosis in experimental animal models. Senescence of hepatic stellate cells could prevent progression of liver fibrosis, although this has not been implemented as a therapy, and would carry the risk of hepatic dysfunction. Cirrhosis

Kidney
CYR61 induction of cellular senescence in the kidney is a potential therapy to limit fibrosis.
Prax may refer to:

Prax (malware), or Regin, a malware and hacking toolkit
Prax Group, operators of Lindsey Oil Refinery, North Killingholme, North Lincolnshire, England
Praso, Italy (German: Prax), a former comune in Trentino, Italy
Mike Prax (born 1956), American politician from Alaska
Valentine Prax (1897–1981), French expressionist and cubist painter