Fibromyalgia is associated with mental health issues like anxiety, posttraumatic stress disorder, bipolar disorder, and depression. Patients with fibromyalgia are five times more likely to have major depression than the general population.Fibromyalgia and numerous chronic pain conditions frequently coexist. These include chronic tension headaches, myofascial pain syndrome, and temporomandibular disorders. Multiple sclerosis, post-polio syndrome, neuropathic pain, and Parkinsons disease are four neurological disorders that have been linked to pain or fibromyalgia. Fibromyalgia largely overlaps with chronic fatigue syndrome and may share the same pathogenetic mechanisms.Comorbid fibromyalgia has been reported to occur in 20–30% of individuals with rheumatic diseases. It has been reported in people with noninflammatory musculoskeletal diseases.The prevalence of fibromyalgia in gastrointestinal disease has been described mostly for celiac disease and irritable bowel syndrome (IBS). Fibromyalgia has also been linked with obesity. Other conditions that are associated with fibromyalgia include an overactive bladder. Risk factors
The cause of fibromyalgia is unknown. However, several risk factors, genetic and environmental,  have been identified. Genetics
Genetics play a major role in fibromyalgia, and may explain up to 50% of the disease susceptibility. Fibromyalgia is potentially associated with polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems. Several genes have been suggested as candidates for susceptibility to fibromyalgia. These include SLC64A4, TRPV2, MYT1L, NRXN3, and the 5-HT2A receptor 102T/C polymorphism.
These controversies do not engage healthcare specialists alone; some patients object to fibromyalgia being described in purely somatic terms.As of 2022, neurologists and pain specialists tend to view fibromyalgia as a pathology due to dysfunction of muscles and connective tissue as well as functional abnormalities in the central nervous system. Rheumatologists define the syndrome in the context of "central sensitization" – heightened brain response to normal stimuli in the absence of disorders of the muscles, joints, or connective tissues. Because of this symptomatic overlap, some researchers have proposed that fibromyalgia and other analogous syndromes be classified together as central sensitivity syndromes. Notes
References
External links
Arthritis – Types – Fibromyalgia by the CDC
Fibromyalgia by the National Institute of Arthritis and Musculoskeletal and Skin Diseases
Fibromyalgia by the American College of Rheumatology
Fibromyalgia by the NHS