Postorgasmic illness syndrome (POIS) is a syndrome in which people have chronic physical and cognitive symptoms following ejaculation. The symptoms usually onset within seconds, minutes, or hours, and last for up to a week. The cause and prevalence are unknown; it is considered a rare disease. Signs and symptoms
The distinguishing characteristics of POIS are:

the rapid onset of symptoms after ejaculation;
the presence of an overwhelming systemic reaction.POIS symptoms, which are called a "POIS attack", can include some combination of the following: cognitive dysfunction, aphasia, severe muscle pain throughout the body, severe fatigue, weakness, and flu-like or allergy-like symptoms, such as sneezing, itchy eyes, and nasal irritation. Additional symptoms include headache, dizziness, lightheadedness, extreme hunger, sensory and motor problems, intense discomfort, irritability, anxiety, gastrointestinal disturbances, craving for relief, susceptibility to nervous system stresses (e.g. common cold), depressed mood, and difficulty communicating, remembering words, reading and retaining information, concentrating, and socializing. Affected individuals may also experience intense warmth or cold. An online anonymous self-report study found that 80% of respondents always experienced the symptom cluster involving fatigue, insomnia, irritation, and concentration difficulties.The symptoms usually begin within 30 minutes of ejaculation, and can last for several days, sometimes up to a week. In some cases, symptoms may be delayed by 2 to 3 days or may last up to 2 weeks.In some men, the onset of POIS is in puberty, while in others, the onset is later in life.
Alezzandrini syndrome is a very rare syndrome characterized by a unilateral degenerative retinitis, followed after several months by ipsilateral vitiligo on the face and ipsilateral poliosis. : 864   Deafness may also be present. : 864

See also
List of cutaneous conditions
Skin lesion

References


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