The latter findings as well as clinical studies in vitro experiments on human tissues support the notion that both parental GATA2 genes are needed to produce levels of the GATA2 transcription factor sufficient for developing and maintaining normal levels of hematological stem and progenitor cells in humans. The transcription factors role in performing this function involves complex and incompletely understood interactions with a network of hematopoietic transcription factors including RUNX1, TAL1, MYB, GFI1, FLI1, LYL1, and PU.1. It is not exactly clear how reduced levels of GATA2 cause any of Emberger syndromes hematological disorders.The role of GATA2 in promoting the normal development of the lymphatic stem cells may be responsible for the other two key features of the Emberger syndrome. That is, failure to develop competent valves and/or vessels in the lymphatic system, it is proposed, is responsible for the lymphedema of Emberger syndrome while failure to generate the perilymphatic space around the inner ears semicircular canals, it is proposed, is responsible for the syndromes sensorineural hearing loss. Diagnosis
Examination of circulating blood cells, bone marrow cells, and the GATA2 nucleotide sequence of individuals with Emberger syndrome typically evidences abnormalities which are not distinctively different from those of individuals with other manifestations of GATA2 deficiency. The specific diagnosis of Emberger syndrome depends on detecting mutations of the GATA2 gene in a setting of clinical findings of hematological disorders, lymphedema, and neurosensory hearing loss.
The demon-king Ravana Ravana is depicted and described as having ten heads, although sometimes he is shown with only nine heads because he has sacrificed a head to convince Shiva. Trishira his son is depicted with three heads. Animal races in Hindu mythology like Nāgas (serpents) may have multiple heads. The Naga Shesha is depicted with five or seven hoods, but said to have infinite hoods. Uchchaihshravas is a celestial seven-headed horse. The divine white elephant Airavata is depicted with multiple heads, trunks and tusks.