SSSS may be difficult to distinguish from toxic epidermal necrolysis and pustular psoriasis. Treatment
The mainstay of treatment for SSSS is supportive care along with eradication of the primary infection. Conservative measures include rehydration, antipyretics (e.g., ibuprofen or paracetamol), management of thermal burns, and stabilization. Parenteral antibiotics to cover S. aureus should be administered. Most strains of S. aureus implicated in SSSS have penicillinases, so are penicillin resistant. Therefore, treatment with nafcillin, oxacillin, or vancomycin is typically indicated. Clindamycin is sometimes also used because of its inhibition of exotoxins. Prognosis
The prognosis of SSSS in children is excellent, with complete resolution within 10 days of treatment, and without significant scarring. However, SSSS must be differentiated carefully from toxic epidermal necrolysis, which carries a poor prognosis. The prognosis in adults is generally much worse, and depends upon various factors such as time to treatment, host immunity, and comorbidities. History
The clinical features were first described in 1878 by Baron Gottfried Ritter von Rittershain, who observed 297 cases among children in a single Czechoslovakian childrens home over a 10-year period.In 1885, Nil Filatow, and in 1894, Clement Dukes, described an exanthematous disease which they thought to be a form of rubella, but in 1900, Dukes identified it to be a separate entity which came to be known by the names Dukes disease, Filatovs disease, or fourth disease.
Desogestrel/ethinylestradiol (EE/DSG), sold under the brand name Marvelon among others, is a fixed-dose combination of desogestrel (DSG), a progestin, and ethinylestradiol (EE), an estrogen, which is used as a birth control pill to prevent pregnancy in women. It is taken by mouth.It was approved for medical use in the United Kingdom in 1981, and in the United States in 1992. In 2019, it was the 128th most commonly prescribed medication in the United States, with more than 5 million prescriptions. See also
List of combined sex-hormonal preparations § Estrogens and progestogens


== References ==