The Anglo-Norman term was a borrowing of Old French ure, a variant of ore, which derived from Latin hōra and Greek hṓrā (ὥρα). Like Old English tīd and stund, hṓrā was originally a vaguer word for any span of time, including seasons and years. Its Proto-Indo-European root has been reconstructed as *yeh₁- ("year, summer"), making hour distantly cognate with year. The time of day is typically expressed in English in terms of hours. Whole hours on a 12-hour clock are expressed using the contracted phrase oclock, from the older of the clock. (10 am and 10 pm are both read as "ten oclock".) Hours on a 24-hour clock ("military time") are expressed as "hundred" or "hundred hours". (1000 is read "ten hundred" or "ten hundred hours"; 10 pm would be "twenty-two hundred".) Fifteen and thirty minutes past the hour is expressed as "a quarter past" or "after" and "half past", respectively, from their fraction of the hour. Fifteen minutes before the hour may be expressed as "a quarter to", "of", "till", or "before" the hour. (9:45 may be read "nine forty-five" or "a quarter till ten".) History
Antiquity
The ancient Greeks kept time differently from the way we do today. Instead of dividing the time between one midnight and the next into 24 equal hours, they divided the time from sunrise to sunset into 12 "seasonal hours" (their actual duration depending on season), and the time from sunset to the next sunrise again in 12 "seasonal hours".
Eisai also markets Zonegran in Asia (China, Taiwan, and fourteen others) and Europe (starting in Germany and the United Kingdom). Research
Tardive dyskinesia
In an open-label trial zonisamide attenuated the symptoms of tardive dyskinesia. Obesity
It has also been studied for obesity with significant positive effects on body weight loss and there are three ongoing clinical trials for this indication. It was to be sold, when combined with bupropion, under the brand name Empatic, until its development was discontinued. Migraine
Zonisamide has been studied for and used as a migraine preventative medication, when topiramate is either ineffective or cannot be continued due to side effects. Bipolar depression
It has also been used off-label by psychiatrists as a mood stabilizer to treat bipolar depression. References
External links
"Zonisamide". Drug Information Portal. U.S. National Library of Medicine.