Mechanism/Pathophysiology
Megaduodenum can be passed down through families, it occurs when a patient inherits one copy of a muted megaduodenum gene from one parent. When the gene gets interrupted in the cells, it causes tumors. Acute pancreatitis, adhesions, aneurysm all clinically lead to Megaduodenum. Diagnosis
Diagnostic tests and procedures can vary for different types of intestinal disorders. These can include colonoscopy, upper GI endoscopy, capsule endoscopy, endoscopic ultrasound. Since patients with megaduodenum often have atypical symptoms such as hematemesis, steatorrhea, and acute pancreatitis. Therefore, physical and histological examination helps demonstrate the grade of distention and the nutritional status of the patient. Many of the physical examinations include: blood pressure, bowel sounds, blood tests, and thyroid function. In addition, a histological examination such as upper endoscopy, an X-ray of the abdomen, and biopsies can also be performed to diagnose megaduodenum efficiently. Prevention/Treatment
The treatment mainly depends on the underlying conditions and the degree of distention of the duodenum. It can be symptomatic and based on diet and control of bacterial overgrowth. To relieve the obstructive symptoms, latero-lateral duodenojejunostomy, gastrojejunostomy, duodenal-jejunal bypass (DJB), enteral and parenteral nutrition may be helpful. Therefore, early diagnosis and treatment may improve patients outcome and reduce morbidity. Prognosis
As long as Megaduodenum is treated promptly, the chances of making full recovery is possible. Posturing maneuvers during meals may be helpful in some patients, also to relive any compression of the duodenum the patient may lie down in right decubitus position. If the conservative treatments fail, surgery may be performed.
Prax may refer to:

Prax (malware), or Regin, a malware and hacking toolkit
Prax Group, operators of Lindsey Oil Refinery, North Killingholme, North Lincolnshire, England
Praso, Italy (German: Prax), a former comune in Trentino, Italy
Mike Prax (born 1956), American politician from Alaska
Valentine Prax (1897–1981), French expressionist and cubist painter