Hippocrates describes the Scythians as being afflicted with high rates of erectile dysfunction and thus "the most eunuchoid of all nations" (Airs Waters Places 22). In the Charlton T. Lewis, Charles Short, A Latin Dictionary, the term literally used for impotent males is spado but may also be used for eunuchs. Some men have falsified the status of their castration to gain entrance into the palace. Chinese eunuch Lao Ai for instance, became the lover of the mother of Qin Shi Huang, who bore him two sons, before Lao Ai and his sons were executed after participating in a rebellion against Qin Shi Huang. Castrato singers
Eunuchs castrated before puberty were also valued and trained in several cultures for their exceptional voices, which retained a childlike and other-worldly flexibility and treble pitch (a high-pitched voice). Such eunuchs were known as castrati. As women were sometimes forbidden to sing in Church, their place was taken by castrati. Castrati became very popular in 18th century opera seria. The practice, known as castratism, remained popular until the 18th century and was known into the 19th century. The last famous Italian castrato, Giovanni Velluti, died in 1861. The sole existing sound recording of a castrato singer documents the voice of Alessandro Moreschi, the last eunuch in the Sistine Chapel choir, who died in 1922. This Italian practice of castrating young males to maintain their soprano voices was ended by Pope Leo XIII (1878). In popular culture
Notable eunuchs
In chronological order.
He thought vaccination offered no advantage over variolation, but maintained friendly contact with Jenner and certainly made no claim of priority for vaccination when critics attacked Jenners reputation. It seems clear that the idea of using cowpox instead of smallpox for inoculation was considered, and actually tried in the late 18th century, and not just by the medical profession. Therefore, Jenner was not the first to try cowpox inoculation. However, he was the first to publish his evidence and distribute vaccine freely, provide information on selection of suitable material, and maintain it by arm-to-arm transfer. The authors of the official World Health Organization (WHO) account Smallpox and its Eradication assessing Jenners role wrote:: 264 
Publication of the Inquiry and the subsequent energetic promulgation by Jenner of the idea of vaccination with a virus other than variola virus constituted a watershed in the control of smallpox for which he, more than anyone else deserves the credit. As vaccination spread, some European countries made it compulsory. Concern about its safety led to opposition and then repeal of legislation in some instances. : 236–40  Compulsory infant vaccination was introduced in England by the 1853 Vaccination Act. By 1871, parents could be fined for non-compliance, and then imprisoned for non-payment. : 202–13  This intensified opposition, and the 1898 Vaccination Act introduced a conscience clause. This allowed exemption on production of a certificate of conscientious objection signed by two magistrates. Such certificates were not always easily obtained and a further Act in 1907 allowed exemption by a statutory declaration which could not be refused.