Decitabine/cedazuridine, sold under the brand name Inqovi, is a fixed-dose combination medication for the treatment of adults with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). It is a combination of decitabine, a nucleoside metabolic inhibitor, and cedazuridine, a cytidine deaminase inhibitor.The most common side effects of decitabine/cedazuridine include fatigue, constipation, hemorrhage, muscle pain (myalgia), mucositis (mouth sores), arthralgia (joint pain), nausea, dyspnea, diarrhea, rash, dizziness, fever with low white blood cell count (febrile neutropenia), edema, headache, cough, decreased appetite, upper respiratory tract infection, pneumonia, and transaminase increased. The combination can cause fetal harm.Decitabine/cedazuridine was approved for medical use in the United States and in Canada in July 2020. Medical uses
Decitabine/cedazuridine is indicated for treatment of adults with myelodysplastic syndromes (MDS), including previously treated and untreated, de novo and secondary MDS with the following French American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, and chronic myelomonocytic leukemia [CMML]) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups.MDS is a type of blood cancer in which blood cells in the bone marrow are defective leading to a low number of one or more types of blood cells. History
Decitabine/cedazuridine was approved for medical use in the United States and in Canada in July 2020.The U.S. Food and Drug Administration (FDA) granted the application of decitabine combined with cedazuridine priority review and orphan drug designation.
It is commercially mined using common underground mining techniques such as bore, drum, and longwall mining in a fashion very similar to coal mining.It is also produced by solution mining, pumping heated water through nahcolite beds and crystalizing the dissolved nahcolite through a cooling crystallization process. In popular culture
Sodium bicarbonate, as "bicarbonate of soda", was a frequent source of punch lines for Groucho Marx in Marx Brothers movies. In Duck Soup, Marx plays the leader of a nation at war. In one scene, he receives a message from the battlefield that his general is reporting a gas attack, and Groucho tells his aide: "Tell him to take a teaspoonful of bicarbonate of soda and a half a glass of water." In A Night at the Opera, Grouchos character addresses the opening night crowd at an opera by saying of the lead tenor: "Signor Lassparri comes from a very famous family. His mother was a well-known bass singer. His father was the first man to stuff spaghetti with bicarbonate of soda, thus causing and curing indigestion at the same time. "In the Joseph L. Mankewicz classic All About Eve, the Max Fabian character (Gregory Ratoff) has an extended scene with Margo Channing (Bette Davis) in which, suffering from heartburn, he requests and then drinks bicarbonate of soda, eliciting a prominent burp. Channing promises to always keep a box of bicarb with Maxs name on it. See also
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International Chemical Safety Card 1044