Mechanism of action
The medication works by binding to and inhibiting the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1) in pancreatic beta cells. This inhibition causes cell membrane depolarization, opening voltage-dependent calcium channels. This results in an increase in intracellular calcium in the pancreatic beta cell and subsequent stimulation of insulin release.After a cerebral ischemic insult, the blood–brain barrier is broken and glibenclamide can reach the central nervous system. Glibenclamide has been shown to bind more efficiently to the ischemic hemisphere. Moreover, under ischemic conditions SUR1, the regulatory subunit of the KATP- and the NCCa-ATP-channels, is expressed in neurons, astrocytes, oligodendrocytes, endothelial cells and by reactive microglia.As per the research papers, this sulphonylurea drugs also has extra hepatic effects. It works by inhibiting the enzyme Carnityl Acyl Transferase I (CAT-I) indirectly which is present in the mitochondria. This prevents the transport of long chain fatty acids into the mitochondria for beta-oxidation. This prevents hyperglycemia for which it is prescribed. History
It was developed in 1966 in a cooperative study between Boehringer Mannheim (now part of Roche) and Hoechst (now part of Sanofi-Aventis). Society and culture
Names
Glibenclamide is available as a generic medication, is manufactured by many pharmaceutical companies and is sold under many brand names including Gliben-J, Daonil, Diabeta, Euglucon, Gilemal, Glidanil, Glybovin, Glynase, Maninil, Micronase and Semi-Daonil. It is also available in a fixed-dose combination drug with metformin that is sold under various trade names, e.g. Bagomet Plus, Benimet, Glibomet, Gluconorm, Glucored, Glucovance, Metglib and many others. References
External links
"Glyburide". Drug Information Portal.
Portia may refer to:

Biology
Portia (spider), a genus of jumping spiders
Anaea troglodyta or Portia, a brush-footed butterfly
Portia tree, a plant native to Polynesia
Ctt. Portia, an orchid Cattlianthe

Medication
A form of birth control made of ethinylestradiol/levonorgestrel

Other uses
Portia (moon), a moon of Uranus
Portia Club, a womens club in Payette, Idaho/USA
Portia, Missouri, a community in the United States
PORTIA portfolio-management software from Thomson Financial
HMS Lennox (1914) or HMS Portia, a Laforey-class destroyer launched in 1914

People with the given name
Portia Arthur (born 1990), Ghanaian author, writer and reporter
Porcia Catonis, the wife of Roman senator Marcus Junius Brutus (fictionalized as  a character in William Shakespeares play Julius Caesar as "Portia")
Portia Dawson, American actress
Portia de Rossi or Portia DeGeneres, Australian-born actress
Portia Doubleday, American actress
Portia Geach (1873–1959), Australian artist and feminist
Portia Holman (1903–1983), Australian child psychiatrist
Portia Mansfield (1887–1979), American dance educator and choreographer
Portia Simpson-Miller, political leader of Jamaicas Peoples National Party and Prime Minister of Jamaica
Portia White, Canadian singer
Portia Zvavahera (born 1985), Zimbabwean painter
Portia, pen name of Abigail Adams (1744-1818)
Portia, pen name of Grizelda Elizabeth Cottnam Tonge (1803-1825)

Fictional
Portia (The Merchant of Venice), a character in William Shakespeares play The Merchant of Venice
Portia Quayne, the protagonist in The Death of the Heart by Elizabeth Bowen
Portia Gibbons, character on The Mighty B!