Eluxadoline has linear pharmacokinetics with no accumulation upon repeated twice daily dosing. Taking eluxadoline with high fat meal decreased the Cmax by 50% and AUC by 60%. Chemistry
Synthesis
The synthesis of eluxadoline was extensively discussed in the patent No. WO2006099060 A2, with the title : "Process for the preparation of opioid modulators" which was published in Sept. 2006

See also
Asimadoline
Axelopran
Difenoxin
Diphenoxylate
Loperamide


== References ==
Fever
poor appetite
anterior fontanelle bulging
seizures
jitteriness
dyspnea
irritability
anorexia
vomiting
diarrhea
abdominal distention (increase in abdominal size)
neck rigidity
cyanosis
jaundice
sunset eyes (downward gaze of the eyes)
abnormal body temperature (hypo-or hyperthermia)
change of activity (lethargy or irritability)These symptoms are unspecific and may point to many different conditions. Complications
Neuroimaging (X-ray imaging of the brain) is recommended to detect the complications of meningitis. Complications should be suspected when the clinical course is characterized by shock, respiratory failure, focal neurological deficits, a positive cerebrospinal fluid culture after 48 to 72 hours of appropriate antibiotic therapy, or infection with certain organisms, such as Citrobacter koseri and Cronobacter sakazakii for example. Ultrasounds are useful for early imaging to determine ventricular size and hemorrhaging. CT scans later in the therapy should be used to dictate prolonged treatment.If intracranial abscesses (collection of pus in the brain) are found, treatment consisting of a combination of surgical drainage of the abscess and antimicrobial therapy for 4 to 6 weeks is recommended. More imaging should be completed after the end of antibiotic treatment because abscesses have been found after weeks from start of treatment.Relapses have also occurred after appropriate treatment when infected by Gram-negative enteric bacilli. Hearing Loss
Meningitis is one of the leading causes of acquired deafness. Nearly 8% of those with Meningitis will have a permanent sensorineural hearing loss. The longer meningitis is left untreated, the greater the risk of seizures and permanent neurological damage such as hearing loss, memory difficulty, learning disabilities, brain damage, gait problems, kidney failure, shock, and even death.