While the adrenal cortex also produces aldosterone (in the zona glomerulosa) and some sex hormones (in the zona reticularis), cortisol is its main secretion in humans and several other species. (However, in cattle, corticosterone levels may approach or exceed cortisol levels.). The medulla of the adrenal gland lies under the cortex, mainly secreting the catecholamines adrenaline (epinephrine) and noradrenaline (norepinephrine) under sympathetic stimulation. The synthesis of cortisol in the adrenal gland is stimulated by the anterior lobe of the pituitary gland with ACTH; ACTH production is, in turn, stimulated by CRH, which is released by the hypothalamus. ACTH increases the concentration of cholesterol in the inner mitochondrial membrane, via regulation of the steroidogenic acute regulatory protein. It also stimulates the main rate-limiting step in cortisol synthesis, in which cholesterol is converted to pregnenolone and catalyzed by Cytochrome P450SCC (side-chain cleavage enzyme). Metabolism
11beta-hydroxysteroid dehydrogenases
Cortisol is metabolized reversibly to cortisone by the 11-beta hydroxysteroid dehydrogenase system (11-beta HSD), which consists of two enzymes: 11-beta HSD1 and 11-beta HSD2. 11-beta HSD1 uses the cofactor NADPH to convert biologically inert cortisone to biologically active cortisol
11-beta HSD2 uses the cofactor NAD+ to convert cortisol to cortisoneOverall, the net effect is that 11-beta HSD1 serves to increase the local concentrations of biologically active cortisol in a given tissue; 11-beta HSD2 serves to decrease local concentrations of biologically active cortisol.
A brother is a man or boy who shares one or more parents with another; a male sibling. The female counterpart is a sister. Although the term typically refers to a familial relationship, it is sometimes used endearingly to refer to non-familial relationships. A full brother is a first degree relative. Overview
The term brother comes from the Proto-Indo-European *bʰréh₂tēr, which becomes Latin frater, of the same meaning. Sibling warmth or affection between male siblings has been correlated to some more negative effects. In pairs of brothers, higher sibling warmth is related to more risk taking behaviour, although risk taking behaviour is not related to sibling warmth in any other type of sibling pair. The cause of this phenomenon in which sibling warmth is only correlated with risk taking behaviours in brother pairs still is unclear. This finding does, however, suggest that although sibling conflict is a risk factor for risk taking behaviour, sibling warmth does not serve as a protective factor. Some studies suggest that girls having an older brother delays the onset of menarche by roughly one year. Research also suggests that the likelihood of being gay increases with the more older brothers a man has. Some analyzers have suggested that a mans attractiveness to a heterosexual woman may increase with the more he resembles her brother, while his unattractiveness may increase the more his likeness diverges from her brother.