Nicotine is specific for nicotinic cholinergic receptors only and has some, but not all of the symptoms of organophosphate poisoning. Diagnosis
Increased nicotine or cotinine (the nicotine metabolite) is detected in urine or blood, or serum nicotine concentrations increase. Treatment
The initial treatment of nicotine  poisoning may include the administration of activated charcoal to try to reduce gastrointestinal absorption. Treatment is mainly supportive and further care can include control of seizures with the administration of a benzodiazepine, intravenous fluids for hypotension, and administration of atropine for bradycardia. Respiratory failure may necessitate respiratory support with rapid sequence induction and mechanical ventilation. Hemodialysis, hemoperfusion or other extracorporeal techniques do not remove nicotine from the blood and are therefore not useful in enhancing elimination. Acidifying the urine could theoretically enhance nicotine excretion, although this is not recommended as it may cause complications of metabolic acidosis. Prognosis
The prognosis is typically good when medical care is provided and patients adequately treated are unlikely to have any long-term sequelae. However, severely affected patients with prolonged seizures or respiratory failure may have ongoing impairments secondary to the hypoxia. It has been stated that if a patient survives nicotine poisoning during the first 4 hours, they usually recover completely. At least at "normal" levels, as nicotine in the human body is broken down, it has an approximate biological half-life of 1–2 hours. Cotinine is an active metabolite of nicotine that remains in the blood for 18–20 hours, making it easier to analyze due to its longer half-life. See also
Nicotine dependence
Nicotine withdrawal

References


== External links ==
Dermatitis repens (also known as Acrodermatitis continua,: 1026  Acrodermatitis perstans, Pustular acrodermatitis, Acrodermatitis continua of Hallopeau, Acrodermatitis continua suppurativa Hallopeau, Hallopeaus acrodermatitis,  Hallopeaus acrodermatitis continua, and Dermatitis repens Crocker) is a rare, sterile, pustular eruption of the fingers and toes that slowly extends proximally. : 1026 : 631 : 195

See also
List of cutaneous conditions
François Henri Hallopeau
Psoriasis
Skin lesion


== References ==