Genetics
This condition is caused by mutations in the WFS1 gene, these mutations are inherited in an autosomal dominant manner, meaning that for a person to exhibit the symptoms of Wolfram-like syndrome, they must have at least one copy of the mutation that is responsible for the phenotype of the disorder, this mutation is usually inherited, but there are cases where the mutation is de novo, meaning that it wasnt inherited from either parent, but rather the result of a spontaneous error in cell division.This gene encodes a protein called wolframin, the mutations typically found in people with this condition cause the production of a protein that is either absent or has little to no function at all.Mutations in this gene are also associated with other disorders affecting vision or hearing, (aside from Wolfram syndrome) such as non-syndromic autosomal dominant deafness type 6., isolated autosomal dominant congenital cataract, etc. In rare cases, a mutation in the CDK13 gene instead of the WFS1 gene is responsible for the disorder, this genetic mutation has only been described in 3 affected children belonging to a consanguineous Pakistani family who, in addition to the typical symptoms of the disorder, also had anomalies affecting the gastrointestinal tract, congenital heart defects, and clinodactyly.
Wolfram-like syndrome is also known to be less severe than Wolfram syndrome itself. See also
Delusional disorder


== References ==