Many surgical approaches are used in the treatment of advanced periodontitis, including open flap debridement and osseous surgery, as well as guided tissue regeneration and bone grafting. The goal of periodontal surgery is access for definitive calculus removal and surgical management of bony irregularities which have resulted from the disease process to reduce pockets as much as possible. Long-term studies have shown, in moderate to advanced periodontitis, surgically treated cases often have less further breakdown over time and, when coupled with a regular post-treatment maintenance regimen, are successful in nearly halting tooth loss in nearly 85% of diagnosed people. Local drug delivery
Local drug deliveries in periodontology has gained acceptance and popularity compared to systemic drugs due to decreased risk in development of resistant flora and other side effects. A meta analysis of local tetracycline found improvement. Local application of statin may be useful. Systemic drug delivery
Systemic drug delivery in conjunction with non-surgical therapy may be used as a means to reduce the percentage of the bacterial plaque load in the mouth. Many different antibiotics and also combinations of them have been tested; however, there is yet very low-certainty evidence of any significant difference in the short and long term compared to non-surgical therapy alone. It may be beneficial to limit the use of systemic drugs, since bacteria can develop antimicrobial resistance and some specific antibiotics might induce temporary mild adverse effects, such as nausea, diarrhoea and gastrointestinal disturbances.
Activity may refer to:

Action (philosophy), in general
Human activity: human behavior, in sociology behavior may refer to all basic human actions, economics may study human economic activities and along with cybernetics and psychology may study their modulation
Recreation, or activities of leisure
The Aristotelian concept of energeia, Latinized as actus
Activity (UML), a major task in Unified Modeling Language
Activity, the rate of catalytic activity, such as enzyme activity (enzyme assay), in physical chemistry and enzymology
Thermodynamic activity, the effective concentration of a solute for the purposes of  mass action
Activity (project management)
Activity, the number of radioactive decays per second
Activity (software engineering)
Activity (soil mechanics)
HMS Activity (D94), an aircraft carrier of the Royal Navy
"Activity", a song by Way Out West from Intensify
Cultural activities, activities referred to culture. See also
Activity theory, a learning theory in education
Social activity (disambiguation), several concepts in the social sciences
Activiti (software), an open source Business Process Management platform
Active (disambiguation)