Certain populations are known to have a higher prevalence of founder mutations, including, but not limited to, French Canadians, Icelanders, African Americans, and Ashkenazi Jews. Lynch syndrome-causing mutations are found in approximately 3% of all diagnosed colorectal cancers, and 1.8% of all diagnosed endometrial cancers. The average age of diagnosis of cancer in patients with this syndrome is 44 years old, as compared to 64 years old in people without the syndrome. Terminology
Henry T. Lynch, Professor of Medicine at Creighton University Medical Center, characterized the syndrome in 1966. In his earlier work, he described the disease entity as "cancer family syndrome." The term "Lynch syndrome" was coined in 1984 by other authors; Lynch named the condition HNPCC in 1985. Since then the two terms have been used interchangeably, until later advances in the understanding of the genetics of the disease led to the term HNPCC falling out of favor.Other sources reserve the term "Lynch syndrome" when there is a known DNA mismatch repair defect, and use the term "familial colorectal cancer type X" when the Amsterdam criteria are met but there is no known DNA mismatch repair defect. The putative "type X" families appear to have a lower overall incidence of cancer and lower risk for non-colorectal cancers than families with documented DNA mismatch repair deficiency. About 35% of people who meet Amsterdam criteria do not have a DNA-mismatch-repair gene mutation.Complicating matters is the presence of an alternative set of criteria, known as the "Bethesda Guidelines."
Notable people with the name include:

Leena (model) (born 1990), Japanese fashion model
Leena Alam, Afghan film actress
Leena Khamis (born 1986), Australian football player of Assyrian-Iraqi descent
Leena Chandavarkar (born 1950), Indian Bollywood actress
Leena Dhingra, British Asian actress
Leena Gade (born c. 1975), British race engineer
Leena Günther (born 1991), German sprint athlete
Leena Harkimo (born 1963), Finnish politician and business executive
Leena Häkinen (1928–1990), Finnish stage, film and television actress
Leena Jumani, Indian actress and model
Leena Kapoor (born 1994), Indian model and actress
Leena Krohn (born 1947), Finnish author
Leena La Bianca (born 1963), Italian American pornographic actress
Leena Lander (born 1955), Finnish author
Leena Lehtolainen (born 1964), Finnish crime novelist
Leena Luhtanen (born 1941), Finnish politician, member of the cabinet
Leena Luostarinen (1949–2013), Finnish painter
Leena Manimekalai, Indian filmmaker, poet and actor
Leena Mohanty, Indian Odissi dancer
Leena Nair (born 1969), Indian businesswoman
Leena Peisa (born 1979), Finnish keyboard player
Leena Peltonen-Palotie (1952–2010), Finnish geneticist
Leena Pietilä (1925–2014), Finnish figure skater
Leena Puotiniemi (born 1976), Finnish long-distance runner
Leena Puranen (born 1986), Finnish football forward
Leena Rauhala (born 1942), Finnish politician, member of the Parliament of Finland
Leena Salmenkylä (born 1958), Finnish orienteering competitor
Leena Silvennoinen (born 1958), Finnish orienteering competitor
Leena Tiwari, Indian politician, member of 17th Legislative Assembly of Mariyahu, Uttar Pradesh
Leena Yadav (born 1971), Indian filmmaker and producer

Fictional characters
Leena (Warehouse 13), from Warehouse 13
A character in Chrono Cross

Media
Leena (film), a Maldivian thriller film
"Leena", a song by Caravan Palace on the 2019 album Chronologic

See also
Lena (name)