Allergic and autoimmune diseases such as severe asthma, rhinitis, or urticarial, chronic sinusitis, aspirin-induced asthma, allergic bronchopulmonary aspergillosis, chronic eosinophilic pneumonia, Kimuras disease, polyarteritis nodosa, eosinophilic granulomatosis with polyangiitis (i.e. Churg–Strauss syndrome), and rejection of transplanted hearts. Malignancies and/or premalignant hematologic conditions not due to a primary disorder in eosinophils such as Gleichs syndrome, Lymphocyte-variant hypereosinophilia Hodgkin disease, certain T-cell lymphomas, acute myeloid leukemia, the myelodysplastic syndromes, systemic mastocytosis, chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, myelofibrosis, chronic myelomonocytic leukemia, and T-lymphoblastic leukemia/lymphoma-associated or myelodysplastic–myeloproliferative syndrome-associated eosinophilias; IgG4-related disease and Angiolymphoid hyperplasia with eosinophilia as well as non-hematologic cancers such as solid tumors of the lung, gastrointestinal tract, and genitourinary tract. Hypersensitivity reactions to agents include:Antibiotics/anti-viral agents: various penicillins (e.g. penicillin, ampicillin), cephalosporins (e.g. cephalosporin), tetracyclins (e.g. tetracycline), sulfonamides (e.g. sulfadiazine, sulfafurazole), sulfonylureas, antituburcular drugs (e.g. isoniazid, 4-aminosalicylic acid), linezolid, amphotericin B, chloramphenicol, streptomycin, dapsone, nitrofurantoin, metronidazole, nevirapine, efavirenz, abacavir, nevirapine. Anticonvulsants/Antipsychotics/antidepressants: phenindione, phenytoin, phenobarbital, lamotrigine, lamotrigine, clozapine, valproic acid, carbamazepine, desipramine, fluoxetine, amitriptyline, olanzapine. Anti-inflammatory agents: ibuprofen, indomethacin, phenylbutazone, oxyphenbutazone, acetazolamide, piroxicam, diclofenac. Diuretics: hydrochlorothiazide, spironolactone, chlortalidone. ACE inhibitors: captopril, enalapril. Other drugs: digoxin, ranitidine, lenalidomide, methyldopa, interleukin 2, dobutamine, acetazolamide. Contaminants: Unidentified contaminants in rapeseed oil cause the toxic oil syndrome and in commercial batches of the amino acid, L-tryptophan, cause the eosinophilia–myalgia syndrome. Vaccinations: Tetanus toxoid, smallpox, and diphtheria/pertussis/tetanus vaccinations. DRESS syndrome
The DRESS syndrome is a severe immunological drug reaction.
Brain fag syndrome (BFS) describes a set of symptoms; somatic, sleep-related and cognitive complaints, difficulty in concentrating and retaining information, head and or neck pains, and eye pain. Brain Fag is very common in adolescents and young adults. It is believed to be the most common in these age ranges due to the immense amount of pressure occurring in life during these years. The condition was arguably first described in Nigerian high school and university students in the 1960s. It is considered a culture-bound syndrome caused by excessive pressure to be successful among the young. Etymology
The term brain fag presumably stems from the verb meaning of the word, "To cause (a person, animal, or part of the body) to become tired; to fatigue, wear out" chiefly found in British English. Classification
BFS is classified in the fourth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) as a culture-bound syndrome. Individuals with symptoms of brain fag must be differentiated from those with the syndrome according to the Brain Fag Syndrome Scale (BFSS); Ola et al said it would not be "surpris[ing] if BFS was called an equivalent of either depression or anxiety". Causes
Brain Fag is typically driven in people with high anxiety and people with high stress levels. Morakinyo found in 20 people with BFS an achievement drive that was anxiety-related that led to the use of psychostimulants and consequent sleep deprivation which contributed to cognitive disruption. Omoluabi related BFS to test anxiety.