There are also reports of patients taking multiple SSRIs with trazodone and precipitating serotonin syndrome.Trazodone appears to be relatively safer than TCAs, MAOIs, and a few of the other second-generation antidepressants in overdose situations, especially when it is the only agent taken. Fatalities are rare, and uneventful recoveries have been reported after ingestion of doses as high as 6,000–9,200 mg. In one report, 9 of 294 cases of overdose were fatal, and all nine patients had also taken other central nervous system (CNS) depressants. When trazodone overdoses occur, clinicians should carefully monitor for low blood pressure, a potentially serious toxic effect. In a report of a fatal trazodone overdose, torsades de pointes and complete atrioventricular block developed, along with subsequent multiple organ failure, with a trazodone plasma concentration of 25.4 mg/L on admission. Interactions
Trazodone is metabolized by several liver enzymes, including CYP3A4, CYP2D6, and CYP1A2. Its active metabolite meta-chlorophenylpiperazine (mCPP) is known to be formed by CYP3A4 and metabolized by CYP2D6. Inhibition or induction of the aforementioned enzymes by various other substances may alter the metabolism of trazodone and/or mCPP, leading to increased and/or decreased blood concentrations. The enzymes in question are known to be inhibited and induced by many medications, herbs, and foods, and as such, trazodone may interact with these substances.
Visceroptosis also is known as Glénards disease (after French physician Frantz Glénard [1848–1920]). Glénards theory – the theory that abdominal ptosis is a nutritional disease with atrophy and prolapse of the intestine
Glénards test (also called girdle test) – while standing behind the patient, the examiner places his arms around the patient, so that his hands meet in front of the patients abdomen; he squeezes, raising the viscera, and then allows them to fall suddenly; Glénards theory suggests that if the patient feels relieved by the raising pressure and experiences distress on the release, the condition is probably one of splanchnoptosis
Stillers theory – the theory that gastroptosis is due to universal asthenia characterized by weakness and laxity of the viscera

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This article incorporates text from a publication now in the public domain: Gilman, D. C.; Peck, H. T.; Colby, F. M., eds. (1905). New International Encyclopedia (1st ed.). New York: Dodd, Mead. {{cite encyclopedia}}: Missing or empty |title= (help)