Gene therapy approaches for treating FVII deficiency are very promising ()

Medical uses
Recombinant factor VIIa, marketed under the trade names AryoSeven and NovoSeven, is used for people with hemophilia (with Factor VIII or IX deficiency) who have developed antibodies against replacement coagulation factor. It has also been used in the setting of uncontrollable hemorrhage, but its role in this setting is controversial with insufficient evidence to support its use outside of clinical trials. The first report of its use in hemorrhage was in an Israeli soldier with uncontrollable bleeding in 1999. Risks of its use include an increase in arterial thrombosis. However, animal studies have not shown complications as seen in humans, in fact same of the studies show a better prognosis. In the military settings it is used as an off label intervention in complications related to disseminated intravascular coagulation related haemorrhage caused by penetrating trauma.Recombinant human factor VII while initially looking promising in intracerebral hemorrhage failed to show benefit following further study and this is no longer recommended. Interactions
Factor VII has been shown to interact with tissue factor and protein kinase C.

References
Further reading
External links
Official website
The MEROPS online database for peptidases and their inhibitors: S01.215
CHES - Comprehensive Health Education Services LLC - Factor VII treatment and awareness [1]
Autoimmune
Multiple sclerosis (neurologic pain interpreted as muscular)
Myositis
Mixed connective tissue disease
Lupus erythematosus
Fibromyalgia syndrome
Familial Mediterranean fever
Polyarteritis nodosa
Devics disease
Morphea
Sarcoidosis

Metabolic defect
Carnitine palmitoyltransferase II deficiency
Conns syndrome
Adrenal insufficiency
Hyperthyroidism
Hypothyroidism
Diabetes
Hypogonadism
Postorgasmic illness syndrome

Other
Chronic fatigue syndrome (aka myalgic encephalomyelitis)
Channelopathy
Ehlers Danlos Syndrome
Stickler Syndrome
Hypokalemia
Hypotonia
Exercise intolerance
Mastocytosis
Peripheral neuropathy
Eosinophilia myalgia syndrome
Barcoo Fever
Herpes
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Delayed onset muscle soreness
HIV/AIDS
Generalized anxiety disorder
Tumor-induced osteomalacia
Hypovitaminosis D
Infarction

Withdrawal syndrome from certain drugs
Sudden cessation of high-dose corticosteroids, opioids, barbiturates, benzodiazepines, caffeine, or alcohol can induce myalgia. Treatment
When the cause of myalgia is unknown, it should be treated symptomatically. Common treatments include heat, rest, paracetamol, NSAIDs, massage, cryotherapy and muscle relaxants. See also
Arthralgia
Myopathy
Myositis

References


== External links ==