Familial LCAT Deficiency Lab Findings
CBC: normochromic normocytic anemia
Urinalysis: proteinuria in young adults (suggestive of kidney failure)
Blood Chemistries: elevated blood urea nitrogen (BUN) and creatinine (suggestive of kidney failure)
Lipid Panel: low high-density lipoprotein (HDL) < 10 mg/dL, elevated very low-density lipoprotein (VLDL) and triglycerides, high plasma unesterified cholesterol, and low plasma cholesterol ester
Plasma LCAT activity: decreased (determined by decreased ability to esterify radioactive cholesterol in exogenous lipoproteins)

Fish-eye Disease Lab Findings
CBC: no anemia
Urinalysis: no protein in the urine
Blood Chemistries: normal blood urea nitrogen (BUN) and creatinine (no signs of kidney failure)
Lipid Panel: low high-density lipoprotein (HDL) < 10 mg/dL, elevated very low-density lipoprotein (VLDL) and triglycerides, high plasma unesterified cholesterol in HDL particles, and low cholesterol ester in HDL particles but normal levels in low-density lipoprotein (LDL) and VLDL particles
Plasma LCAT activity: decreased only in HDL particles but not LDL

Genetic Findings in Fish-eye Disease
Mutations in the LCAT gene, which is localized in the q21–22 region of chromosome 16, cause fish-eye disease. The mutation in the LCAT gene is homozygous for a Thr123→Ile mutation or Pro10→Leu mutation. New mutations have been identified as homozygosity for an A2205→G nucleotide substitution in exon 4 of the LCAT gene which is predicted to be the cause of an Asp131→Asn substitution. Treatment
Currently, there is no specific treatment to correct the LCAT deficiency so therapy is focused on symptom relief. Corneal transplant may be considered for patients presenting with severely impaired vision caused by cholesterol corneal opacities. Dialysis may be required for patients presenting with kidney failure, and kidney transplant may be considered.
Smear may refer to:

A smear test, wherein a sample is smeared over a microscope slide to be studied for any pathology
A smear test usually refers to a pap test, that is, a cervical smear
Smear (card game)
Smear Lake, a lake in Wisconsin
Smear campaign, or smear job,  an attack on the reputation of an individual or group making use of disinformation tactics
Smear Campaign (album), an album by Napalm Death
Pat Smear, the guitarist and actor
Smear (optics), motion that degrades sharpness, which is generally linear over the integration time
Colloquial name for a glissando, a glide from one musical pitch to anotherSmearing may refer to:

Smearing of an image taken by an astronomical interferometer:
Bandwidth smearing, a chromatic aberration;
Time smearing, a consequence of Earth rotation during the observation;
Smearing (climbing), a technique of rock climbing
Electron smearing, a tool for improving convergence in DFT calculations

See also
Smeared, the debut studio album by Canadian rock band Sloan