The amide-linked product between the amino acid and the amino-octose bound to ergothioneine is then the substrate of LmbV, which substitute ergothioneine by mycothiol. The mycothiol moiety is then cleaved by LmbE, and the product is further processed by LmbIH, LmbQ, LmbJ, LmbF and is finally sulphur methylated by LmbG, to afford lincomycin. Spectrum of susceptibility
Lincomycin is a narrow spectrum antibiotic with activity against Gram-positive and cell wall-less bacteria including pathogenic species of Streptococcus, Staphylococcus, and Mycoplasma. Lincomycin is used to treat severe bacterial infections in patients who cannot use penicillin antibiotics. Lincomycin shows weak activity against most Gram-negative bacteria. The following represents susceptibility (MIC) data for a few pathogenic bacteria:

Staphylococcus aureus - 0.2 µg/mL - 32 µg/mL
Streptococcus pneumoniae - 0.05 µg/mL - 0.4 µg/mL
Streptococcus pyogenes - 0.04 µg/mL - 0.8 µg/mL

See also
Lincosamides


== References ==
In 2021 it was discovered that Fusarium xyrophilum was able to hijack a South American species of yellow-eyed Xyris grass, creating fake flowers, fooling bees and other pollinating insects into visiting them, taking fungal spores to other plants. In humans
Some species may cause a range of opportunistic infections in humans. In humans with normal immune systems, fusarial infections may occur in the nails (onychomycosis) and in the cornea (keratomycosis or mycotic keratitis). In humans whose immune systems are weakened in a particular way, (neutropenia, i.e., very low neutrophils count), aggressive fusarial infections penetrating the entire body and bloodstream (disseminated infections) may be caused by members of the Fusarium solani complex, Fusarium oxysporum, Fusarium verticillioides, Fusarium proliferatum and, rarely, other fusarial species. Research
The isolation medium for Fusaria is usually peptone PCNB agar (peptone pentachloronitrobenzene agar, PPA). : 7  For F. oxysporum specifically, Komadas medium is most common. : 7  Differential identification is difficult in some strains. Vegetative compatibility group analysis is best for some, is one usable method for others, and requires such a large number of assays that it is too complicated for yet others. Use as human food
Fusarium venenatum is produced industrially for use as a human food by Marlow Foods, Ltd., and is marketed under the name Quorn in Europe and North America. Also, Fusarium str. yellowstonensis is under investigation for similar foods.Some consumers of fusarium products have shown food allergies similar in nature to peanut and other food allergies. People with known sensitivities to molds should exercise caution when consuming such products.