In humans, tolerance to the anticonvulsant effects of diazepam occurs frequently. Dependence
Improper or excessive use of diazepam can lead to dependence. At a particularly high risk for diazepam misuse, substance use disorder or dependence are:

People with a history of a substance use disorder or substance dependence Diazepam increases craving for alcohol in problem alcohol consumers. Diazepam also increases the volume of alcohol consumed by problem drinkers. People with severe personality disorders, such as borderline personality disorderPatients from the aforementioned groups should be monitored very closely during therapy for signs of abuse and development of dependence. Therapy should be discontinued if any of these signs are noted, although if dependence has developed, therapy must still be discontinued gradually to avoid severe withdrawal symptoms. Long-term therapy in such instances is not recommended.People suspected of being dependent on benzodiazepine drugs should be very gradually tapered off the drug. Withdrawals can be life-threatening, particularly when excessive doses have been taken for extended periods of time. Equal prudence should be used whether dependence has occurred in therapeutic or recreational contexts.Diazepam is a good choice for tapering for those using high doses of other benzodiazepines since it has a long half-life thus withdrawal symptoms are tolerable. The process is very slow (usually from 14 to 28 weeks) but is considered safe when done appropriately.
Fluorosis may refer to:

Dental fluorosis, a disturbance of dental enamel caused by excessive exposure to high concentrations of fluoride during tooth development. Skeletal fluorosis, a bone disease caused by excessive accumulation of fluoride in the bones
Fluoride toxicity, elevated levels of the fluoride ion in the body