The condition is named after surgeon Norman Barrett (1903–1979) even though the condition was originally described by Philip Rowland Allison in 1946. Signs and symptoms
The change from normal to premalignant cells indicate Barretts esophagus does not cause any particular symptoms. Barretts esophagus, however, is associated with these symptoms:

frequent and longstanding heartburn
trouble swallowing (dysphagia)
vomiting blood (hematemesis)
pain under the sternum where the esophagus meets the stomach
pain when swallowing (odynophagia), which can lead to unintentional weight lossThe risk of developing Barretts esophagus is increased by central obesity (vs. peripheral obesity). The exact mechanism is unclear. The difference in distribution of fat among men (more central) and women (more peripheral) may explain the increased risk in males. Pathophysiology
Barretts esophagus occurs due to chronic inflammation. The principal cause of chronic inflammation is gastroesophageal reflux disease, GERD (UK: GORD). In this disease, acidic stomach, bile, and small intestine and pancreatic contents cause damage to the cells of the lower esophagus. In turn, this provokes an advantage for cells more resistant to these noxious stimuli in particular HOXA13-expressing stem cells that are characterised by distal (intestinal) characteristics and outcompete the normal squamous cells.This mechanism also explains the selection of HER2/neu (also called ERBB2) and the overexpressing (lineage-addicted) cancer cells during the process of carcinogenesis, and the efficacy of targeted therapy against the Her-2 receptor with trastuzumab (Herceptin) in the treatment of adenocarcinomas at the gastroesophageal junction. Researchers are unable to predict who with heartburn will develop Barretts esophagus.
Coarse facial features or coarse facies describes a constellation of facial features that are present in many inborn errors of metabolism. Features include:
large, bulging head
prominent scalp veins
"saddle-like, flat bridged nose with broad, fleshy tip"
large lips and tongue
small, widely spaced and/or malformed teeth
hypertrophic alveolar ridges and/or gumsHeads tend to be longer than normal from front to back, with a bulging forehead. This is because of the earlier than normal or premature fusion of skull bones in an affected individual. Causes
Several conditions are associated with coarse facial features. Acromegaly
Alpha-mannosidosis type II
Aspartylglycosaminuria
Battaglia Neri syndrome
Borjeson Syndrome
Chromosome 6q deletion syndrome
Coarse face - hypotonia - constipation
Congenital hypothyroidism
Dandy-Walker malformation (with mental retardation basal ganglia disease and seizures)
Dyggve-Melchior-Clausen Syndrome
Fucosidosis type 1
Fucosidosis type II
Gangliosidosis generalized GM1 (type 1)
Gangliosidosis GM1 (type 3)
GM1 gangliosidosis
Goldberg syndrome
Hyde-Forster-Mccarthy-Berry syndrome
Hyper IgE
Hypomelanosis of Ito
I cell disease
Immunodeficiency due to defect in MAPBP-interacting protein
Infantile sialic acid storage disorder
Job syndrome
Mannosidosis (alpha B lysosomal)
McCune-Albright Syndrome
Mental retardation (X-linked - epilepsy - progressive joint contractures - typical face)
Mental retardation (X-linked Raynaud type)
Mieschers syndrome
Morquio syndrome
Morquio syndrome type A
Morquio syndrome type B
MPS 3 C
MPS 3 D
Mucolipidosis III
Mucopolysaccharidosis type 2 Hunter syndrome- mild form
Mucopolysaccharidosis type 2 Hunter syndrome- severe form
Mucopolysaccharidosis type 3
Mucopolysaccharidosis type 6
Mucopolysaccharidosis type 7 Sly syndrome
Mucopolysaccharidosis type I Hurler syndrome
Mucopolysaccharidosis type I Hurler/Scheie syndrome
Mucopolysaccharidosis type I Scheie syndrome
Multiple endocrine abnormalities - adenylyl cyclase dysfunction
Multiple endocrine neoplasia type 2b
Neuraminidase deficiency (type II juvenile form)
Nodulosis-arthropathy-osteolysis syndrome
Nonkeratan-sulfate-excreting Morquio syndrome
Pituitary tumors (adult)
Sialidosis type II (congenital)
Sialidosis type II (infantile)
Sialuria syndrome
Simpson-Golabi-Behmel syndrome
Simpson-Golabi-Behmel syndrome - type 1 (SGBS1)
Skeletal dysplasia - coarse facies - mental retardation
Spondyloepimetaphyseal dysplasia (genevieve type)
Sulfatidosis juvenile (Austin type)
Winchester syndrome

See also
Facies (medical)

References
External links
https://web.archive.org/web/20090106211640/http://www.mps1disease.com/patient/about/mps_pt_symptom_coarse_facial_features.asp