"Consciousness" (French: conscience) is also defined in the 1753 volume of Diderot and dAlemberts Encyclopédie, as "the opinion or internal feeling that we ourselves have from what we do".The earliest English language uses of "conscious" and "consciousness" date back, however, to the 1500s. The English word "conscious" originally derived from the Latin conscius (con- "together" and scio "to know"), but the Latin word did not have the same meaning as the English word—it meant "knowing with", in other words, "having joint or common knowledge with another". There were, however, many occurrences in Latin writings of the phrase conscius sibi, which translates literally as "knowing with oneself", or in other words "sharing knowledge with oneself about something". This phrase had the figurative meaning of "knowing that one knows", as the modern English word "conscious" does. In its earliest uses in the 1500s, the English word "conscious" retained the meaning of the Latin conscius. For example, Thomas Hobbes in Leviathan wrote: "Where two, or more men, know of one and the same fact, they are said to be Conscious of it one to another." The Latin phrase conscius sibi, whose meaning was more closely related to the current concept of consciousness, was rendered in English as "conscious to oneself" or "conscious unto oneself". For example, Archbishop Ussher wrote in 1613 of "being so conscious unto myself of my great weakness". Lockes definition from 1690 illustrates that a gradual shift in meaning had taken place. A related word was conscientia, which primarily means moral conscience.
This can be distinguished from hereditary orotic aciduria by assessing blood ammonia levels and blood urea nitrogen (BUN). In OTC deficiency, hyperammonemia and decreased BUN are seen because the urea cycle is not functioning properly, but megaloblastic anemia will not occur because pyrimidine synthesis is not affected. In orotic aciduria, the urea cycle is not affected. Orotic aciduria can be diagnosed through genetic sequencing of the UMPS gene. Treatment
Treatment is administration of uridine monophosphate (UMP) or uridine triacetate (which is converted to UMP). These medications will bypass the missing enzyme and provide the body with a source of pyrimidines. References


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