Type 3 is a more severe presentation of type 1 and is caused by a mutation in the same gene, while type 4 is most often caused by a mutation in SOX10. Mutations in other genes can also cause the different types, and some of these have been given their own lettered subtypes. Most types are autosomal dominant. The estimated prevalence of Waardenburg syndrome is 1 in 42,000. Types 1 and 2 are the most common, comprising approximately half and a third of cases, respectively, while type 4 comprises a fifth and type 3 less than 2% of cases. An estimated 2–5% of congenitally deaf people have Waardenburg syndrome. Descriptions of the syndrome date back to at least the first half of the 20th century, however it is named after Dutch ophthalmologist and geneticist Petrus Johannes Waardenburg, who described it in 1951. Its subtypes were progressively discovered in the following decades and had genes attributed to them mostly in the 1990s and 2000s. Signs and symptoms
Waardenburg syndrome has multiple different types with some variations in symptoms, and symptoms can vary among those with the same type. The two features consistent across all types of Waardenburg syndrome are some degree of congenital sensorineural hearing loss and some degree of pigmentation deficiencies, most consistently in the eyes.
Onset may refer to:

Onset (audio), the beginning of a musical note or sound
Onset, Massachusetts, village in the United States
Onset Island (Massachusetts), a small island located at the western end of the Cape Cod Canal
Interonset interval, a term in music
Syllable onset, a term in phonetics and phonology
The Onset, Liverpool indie rock group formed by Mike Badger of the Las
The Onset (album), a 2005 album by the band
USS Onset (SP-1224), a United States Navy patrol boat in commission from 1917 to 1918
"Onset", a 2019 song by Haiku Hands

See also
Offset (disambiguation)