This effect is avoided with concurrent utilisation of 5α-reductase inhibitors, such as finasteride, or flutamide which function to block the downstream effects of testosterone. Available forms
Leuprorelin is available in the following forms, among others:
Short-acting daily intramuscular injection (Lupron)
Long-acting depot intramuscular injection (Lupron Depot)
Long-acting depot subcutaneous injection (Eligard)
Long-acting subcutaneous injection (Fensolvi)
Long-acting subcutaneous implant (Viadur)
Long-acting leuprolide mesylate (Camcevi) for the treatment of advanced prostate cancer. Leuprolide acetate and norethindrone acetate combination pack (Lupaneta Pack)

Chemistry
The peptide sequence is Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-pyroglutamyl). History
Leuprorelin was discovered and first patented in 1973 and was introduced for medical use in 1985. It was initially marketed only for daily injection, but a depot injection formulation was introduced in 1989. Approvals
Lupron injection was approved by the FDA for treatment of advanced prostate cancer on April 9, 1985. Lupron depot for monthly intramuscular injection was approved by the FDA for palliative treatment of advanced prostate cancer on January 26, 1989. Viadur was approved by the FDA for palliative treatment of advanced prostate cancer on March 6, 2000. Eligard was approved by the FDA for palliative treatment of advanced prostate cancer on January 24, 2002. Fensolvi was approved by the FDA for children with central precocious puberty on May 4, 2020.
This results in minimal reflexive sympathetic changes.Diltiazem has negative inotropic, chronotropic, and dromotropic effects. This means diltiazem causes a decrease in heart muscle contractility – how strong the beat is, lowering of heart rate – due to slowing of the sinoatrial node, and a slowing of conduction through the atrioventricular node – increasing the time needed for each beat. Each of these effects results in reduced oxygen consumption by the heart, reducing angina, typically unstable angina, symptoms. These effects also reduce blood pressure by causing less blood to be pumped out. Research
Diltiazem is prescribed off-label by doctors in the US for prophylaxis of cluster headaches. Some research on diltiazem and other calcium channel antagonists in the treatment and prophylaxis of migraine is ongoing.Recent research has shown diltiazem may  reduce cocaine cravings in drug-addicted rats. This is believed to be due to the effects of calcium blockers on dopaminergic and glutamatergic signaling in the brain. Diltiazem also enhances the analgesic effect of morphine in animal tests, without increasing respiratory depression, and reduces the development of tolerance.Diltiazem is also being used in the treatment of anal fissures. It can be taken orally or applied topically with increased effectiveness. When applied topically, it is made into a cream form using either vaseline or Phlojel. Phlojel absorbs the diltiazem into the problem area better than the vaseline base. It has good short-term success rates. References
External links
"Diltiazem". Drug Information Portal. U.S. National Library of Medicine.