Cogan syndrome (also Cogans syndrome) is a rare disorder characterized by recurrent inflammation of the front of the eye (the cornea) and often fever, fatigue, and weight loss, episodes of vertigo (dizziness), tinnitus (ringing in the ears) and hearing loss. It can lead to deafness or blindness if untreated. The classic form of the disease was first described by D. G. Cogan in 1945. Signs and symptoms
Cogan syndrome is a rare, rheumatic disease characterized by inflammation of the ears and eyes. Cogan syndrome can lead to vision difficulty, hearing loss and dizziness. The condition may also be associated with blood-vessel inflammation (called vasculitis) in other areas of the body that can cause major organ damage in 15% of those affected or, in a small number of cases, even death. It most commonly occurs in a persons 20s or 30s. The cause is not known. However, one theory is that it is an autoimmune disorder in which the bodys immune system mistakenly attacks tissue in the eye and ear. Causes
It is currently thought that Cogan syndrome is an autoimmune disease. The inflammation in the eye and ear are due to the patients own immune system producing antibodies that attack the inner ear and eye tissue. Autoantibodies can be demonstrated in the blood of some patients, and these antibodies have been shown to attack inner ear tissue in laboratory studies.
Pyostomatitis vegetans is an inflammatory stomatitis and most often seen in association with inflammatory bowel disease, namely ulcerative colitis and Crohns disease. Uncommonly, it may be one of the features of orofacial granulomatosis. See also
Cheilitis
Skin lesion
List of cutaneous

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Pyostomatitis vegetans associated with inflammatory bowel disease