Nonetheless, no gene polymorphisms were found within the promoters, exons, or introns of these 3 genes or in the regions IL-3/GM-CSF enhancer. In addition to these studies, 8 affected members of a family with familial eosinophilia had peripheral blood or bone marrow cells that carried the same chromosome abnormality, a pericentric inversion of chromosome 10, inv (10) (p11.2q21.2). The meaning and relationship, if any, of this inversion to familial eosinophilia is unclear. Pathophysiology
Earlier studies found no evidence of abnormal blood levels of interleukin 5, interleukin 3, or granulocyte-macrophage colony stimulating factor. A more recent study used a more sensitive assay for interleukin 5 to compare members of a single extended family with some members lacking the disorder. The study found that members with the disorder had: a) peripheral blood mononuclear cells as well as T helper cells (major physiological source of interleukin 5), CD8+ cells, CD14+ cells, and CD19+ cells that expressed high levels of messenger RNA for interleukin 5 while their peripheral blood mononuclear cells expressed normal levels of messenger RNA for RAD50, a gene in close proximity to IL-5; b) elevated serum levels of interleukin 5 as well as soluble Interleukin 5 receptor alpha subunit; and c) innate lymphoid cells (also major physiological sources of interleukin 5) that produced increased amounts of interleukin 5 in response to stimulation. A second family with asymptomatic eosinophilia over three generations likewise exhibited increased production of interleukin 5.
Videx, Inc. is a Corvallis, Oregon manufacturer of computer hardware such as access control products and data collection terminals. Its initial success came with the first release of the $345 Videoterm (80 column) display card in March 1980 and the $149 shift and custom keyboard mapping Enhancer II terminal card in November 1981, both for Apple II computers. Later, in 1984, it released its $379 UltraTerm expansion card boasting high-definition 96-pixel characters and up to 128 × 32 character display. These products became obsolete when Apple released the Apple IIe with most of the 80-column card hardware built-in - only a much simpler and cheaper RAM card was then required. Videx also produced software, including Desktop Calendar for the Apple Lisa. References
External links
Official website