Carcinoid tumors, particularly those derived from the embryologic foregut (lungs, thymus), occur in isolated cases. Multiple subcutaneous and visceral lipomas, angiofibromas, and collagenomas may also occur. Genetic
People with multiple endocrine neoplasia type 1 are born with one mutated copy of the MEN1 gene in each cell. Then, during their lifetime, the other copy of the gene is mutated in a small number of cells. These genetic changes result in no functional copies of the MEN1 gene in selected cells, allowing the cells to divide with little control and form tumors. This is known as Knudsons two-hit hypothesis and is a common feature seen with inherited defects in tumor suppressor genes. Oncogenes can become neoplastic with only one activating mutation, but tumor suppressors inherited from both mother and father must be damaged before they lose their effectiveness. The exception to the "two-hit hypothesis" occurs when suppressor genes exhibit dose-response, such as ATR. The exact function of MEN1 and the protein, menin, produced by this gene is not known, but following the inheritance rules of the "two-hit hypothesis" indicates that it acts as a tumor suppressor. Diagnosis
In a diagnostic workup individuals with a combination of endocrine neoplasias suggestive of the MEN1 syndrome are recommended to have a mutational analysis of the MEN1 gene if additional diagnostic criteria are sufficiently met, mainly including:
age <40 years
positive family history
multifocal or recurrent neoplasia
two or more organ systems affected

Types
Multiple endocrine neoplasia or MEN is part of a group of disorders that affect the bodys network of hormone-producing glands (the endocrine system).
A papulosquamous disorder is a condition which presents with both papules and scales, or both scaly papules and plaques.Examples include psoriasis, lichen planus, and pityriasis rosea. See also
List of cutaneous conditions

References
Further reading
Norman RA, Blanco PM (2003). "Papulosquamous diseases in the elderly". Dermatologic Therapy. 16 (3): 231–42. doi:10.1046/j.1529-8019.2003.01633.x. PMID 14510880.
http://www.emedicine.com/derm/index.shtml#papulosquamous


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