At that time, most construction trades and industries were unaware of the potential risks associated with beryllium exposure.It occasionally killed early workers in nuclear weapons design, such as Herbert L. Anderson.Beryllium sensitivity testing was first performed as a cutaneous beryllium patch test in the early 1950s, but was discontinued due to the test stimulating sensitization or aggravating existing chronic beryllium disease. : 115 In the 1990s, the DOE began screening employees using the BeLPT test in facilities where beryllium was used, in order to take preventive measures against beryllium exposure; somewhat alarmingly, clerical staff who were never involved in handling the material had developed asymptomatic sensitivities.The 1954 Isaac Asimov short story "Sucker Bait" is largely concerned with a space colony dying of Beryllium poisoning. References
External links

ATSDR Case Studies in Environmental Medicine: Beryllium Toxicity U.S. Department of Health and Human Services
CDC – Research on Beryllium Sensitization and Chronic Beryllium Disease – NIOSH Workplace Safety and Health Topic
Beryllium Network
Health-cares.net
Instant insight from the Royal Society of Chemistry examining the molecular basis of chronic beryllium disease
Rosner, David; Markowitz, Gerald E. (February 1987). "Ch. 7: Salem Sarcoid:The Origins of Beryllium Disease". Dying for work: workers safety and health in twentieth-century America. Indiana University Press. pp. 103–. ISBN 978-0-253-31825-1.
The FDA approval was conditioned on Mitsubishi Tanabe completing several additional studies to clarify the risks of cancer and liver disease, among other effects of the medication.Formulation of edaravone by mouth called TW001 (mixture of the edaravone and SBE-HP-βCD ) has been under development by Treeway for ALS; as of 2015, it had successfully completed Phase I trial and had received orphan status in the US and in the European Union.An oral formulation of edaravone was approved for medical use in the United States in May 2022. The effectiveness of oral edaravone is based on a study that showed comparable levels of oral edaravone in the bloodstream to the levels from the IV formulation of edaravone. The efficacy of edaravone for the treatment of ALS was previously demonstrated in a six-month clinical trial that served as the basis for approval in 2017. In that trial, 137 participants were randomized to receive edaravone or placebo. At week 24, individuals receiving edaravone declined less on a clinical assessment of daily functioning compared to those receiving placebo. Society and culture
Economics
The price for the medication when it launched in Japan for stroke in 2001, was set by the Japanese government at 9,931 yen/ampule.When the medication launched in Japan for ALS in 2001, the price was $35,000; the price in Japan in 2017 was $5,000, the US price at launch was around $145,000.