Female athletes are more likely to jump and land with their knees relatively straight and collapsing in towards each other, while most of their bodyweight falls on a single foot and their upper body tilts to one side. Several theories have been described to further explain these imbalances. These include the ligament dominance, quadriceps dominance, leg dominance, and trunk dominance theories.The ligament dominance theory suggests that when females athletes land after a jump, their muscles do not sufficiently absorb the impact of the ground. As a result, the ligaments of the knee must absorb the force, leading to a higher risk of injury. Quadriceps dominance refers to a tendency of female athletes to preferentially use the quadriceps muscles to stabilize the knee joint. Given that the quadriceps muscles work to pull the tibia forward, an overpowering contraction of the quadriceps can place strain on the ACL, increasing risk of injury.Leg dominance describes the observation that women tend to place more weight on one leg than another. Finally, trunk dominance suggests that males typically exhibit greater control of the trunk in performance situations as evidenced by greater activation of the internal oblique muscle. Female athletes are more likely to land with their upper body tilted to one side and more weight on one leg than the other, therefore placing greater rotational force on their knees. Hormonal and anatomic differences
Before puberty, there is no observed difference in frequency of ACL tears between the sexes.
Bone abnormalities can be seen on radiological imaging (often increased density or osteosclerosis) or  biopsy.There are two sets of diagnostic criteria, the Lipsker criteria published in 2001 and the Strasbourg criteria that were produced at a meeting in that city in 2012.The Lipsker criteria require hives, the presence of monoclonal IgM, and at least 2 of the following: fever, joint pain or arthritis, bone pain, swollen lymph nodes, enlarged spleen or liver, elevated erythrocyte sedimentation rate, high levels of white blood cells, and findings of problems in bone imaging.In the Strasbourg criteria, the person must have hives and the presence of monoclonal IgM or IgG. Schnitzlers is diagnosed if the person has IgM and two of the following, or IgG and three of the following: recurrent fevers, abnormalities in bone imaging, with or without bone pain, findings of neutrophil infiltration in a skin biopsy, high levels of white blood cells or C-reactive protein.Other conditions which can cause periodic fevers, paraproteins or chronic hives that should be ruled out, include (and are not limited to) autoimmune or autoinflammatory disorders such as adult-onset Stills disease, angioedema, hematological disorders such as lymphoma or monoclonal gammopathy of undetermined significance (MGUS), other causes of hives, cryoglobulinemia, mastocytosis, chronic neonatal onset multisystem inflammatory disease or Muckle–Wells syndrome. Treatment
As of 2017 no drug was approved to treat Schnitzlers. Drugs that inhibit interleukin 1 activity have been the preferred treatment since they emerged in 2005; since 2012 a consensus guideline has recommended treatment with anakinra.