Increased beta activity and decreased delta wave activity has been observed on electroencephalograms; however, the implication of this is unknown.Around half of post-menopausal women experience sleep disturbances, and generally sleep disturbance is about twice as common in women as men; this appears to be due in part, but not completely, to changes in hormone levels, especially in and post-menopause.Changes in sex hormones in both men and women as they age may account in part for increased prevalence of sleep disorders in older people. Diagnosis
In medicine, insomnia is widely measured using the Athens insomnia scale. It is measured using eight different parameters related to sleep, finally represented as an overall scale which assesses an individuals sleep pattern. A qualified sleep specialist should be consulted for the diagnosis of any sleep disorder so the appropriate measures can be taken. Past medical history and a physical examination need to be done to eliminate other conditions that could be the cause of insomnia. After all other conditions are ruled out a comprehensive sleep history should be taken. The sleep history should include sleep habits, medications (prescription and non-prescription), alcohol consumption, nicotine and caffeine intake, co-morbid illnesses, and sleep environment. A sleep diary can be used to keep track of the individuals sleep patterns. The diary should include time to bed, total sleep time, time to sleep onset, number of awakenings, use of medications, time of awakening, and subjective feelings in the morning.
Other symptoms which should be reported immediately include difficulty in breathing, swelling of the face, white patches in the throat, mouth, or nose, irregular menstrual periods, severe acne, and on rare occasions, behavioral changes (mostly affecting children)

Contraindications
Budesonide is contraindicated as a primary treatment of status asthmaticus or other acute episode of asthma where intensive measures are required. It is also contraindicated for patients who have hypersensitivity to budesonide. Interactions
Those taking tablets or capsules orally should avoid grapefruit and grapefruit juice and echinacea. : 160 
Grapefruit juice may double bioavailability of oral budesonide. Echinacea diminishes bioavailability.Also, high-fat meals delay absorption but do not impede absorption. Pharmacology
Budesonide is an agonist of glucocorticoid receptors. Among its effects are:

Controls the rate of protein synthesis. Depresses the migration of polymorphonuclear leukocytes and fibroblasts. Reverses capillary permeability and lysosomal stabilization at the cellular level to prevent or control inflammation. Has a potent glucocorticoid activity and weak mineralocorticoid activity. Pharmacokinetics
Onset of action: Nebulization: 2–8 days; Inhalation: 24 hours; Nasal: 10 hours
Peak effect: Nebulization: 4–6 weeks; Inhalation: 1–2 weeks
Distribution: 2.2-3.9 L/kg
Protein binding: 85% to 90%
Metabolism: Hepatic via CYP3A4 to two metabolites: 16 alpha-hydroxyprednisolone and 6 beta-hydroxybudesonide; minor activity
Budesonide is extensively metabolized in first pass, resulting in a low bioavailability and systemic effects
Bioavailability: Capsule: 9% to 21%; Nebulization: 6%; Inhalation: 6% to 13%
Half-life elimination: 2–3.6 hours
Time to peak: Capsule: 0.5–10 hours (variable in Crohns disease); Nebulization: 10–30 minutes; Inhalation: 1–2 hours; Tablet: 7.4-19.2 hours
Excretion: urine (60%) and feces as metabolites. Chemistry
Budesonide, also known as 11β,21-dihydroxy-16α,17α-(butylidenebis(oxy))pregna-1,4-diene-3,20-dione, is a synthetic pregnane steroid and non-halogenated cyclic ketal corticosteroid.