It is also used off-label in the treatment of cyclical vomiting syndrome in infants; the only evidence for this use comes from retrospective studies.Cyproheptadine is sometimes used off-label to improve akathisia in people on antipsychotic medications.It is used off-label to treat various dermatological conditions, including psychogenic itch  drug-induced hyperhidrosis (excessive sweating), and prevention of blister formation for some people with epidermolysis bullosa simplex.One of the effects of the drug is increased appetite and weight gain, which has led to its use (off-label in the USA) for this purpose in children who are wasting as well as people with cystic fibrosis.It is also used off-label in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors (and monoamine oxidase inhibitors), and in cases of high levels of serotonin in the blood resulting from a serotonin-producing carcinoid tumor.Cyproheptadine has sedative effects and can be used to treat insomnia similarly to other centrally-acting antihistamines. The recommended dose for this use is 4 to 8 mg. Adverse effects
Adverse effects include:

Overdose
Gastric decontamination measures such as activated charcoal are sometimes recommended in cases of overdose. The symptoms are usually indicative of CNS depression (or conversely CNS stimulation in some) and excess anticholinergic side effects. The LD50 in mice is 123 mg/kg and 295 mg/kg in rats. Pharmacology
Pharmacodynamics
Cyproheptadine is a very potent antihistamine or inverse agonist of the H1 receptor. At higher concentrations, it also has anticholinergic, antiserotonergic, and antidopaminergic activities.
They are so expensive that gene therapy for haemophilia might be less expensive, especially for people with severe hemophilia. See also
Damoctocog alfa pegol, a recombinant antihemophilic factor VIII
Efmoroctocog alfa, a recombinant antihemophilic factor VIII
Moroctocog alfa, a recombinant antihemophilic factor VIII
Susoctocog alfa, a recombinant antihemophilic factor VIII
Turoctocog alfa, a recombinant antihemophilic factor VIII

References
External links
"Blood-coagulation factor VIII, procoagulant". Drug Information Portal. U.S. National Library of Medicine. "Beroctocog alfa". Drug Information Portal. U.S. National Library of Medicine. "Antihemophilic Factor (Recombinant) Monograph for Professionals". Drugs.com. "Antihemophilic Factor (Recombinant), Porcine Sequence Monograph for Professionals". Drugs.com. "Antihemophilic Factor (recombinant), Fc Fusion Protein Monograph for Professionals". Drugs.com. "Antihemophilic Factor (recombinant), Glycopegylated-exei Monograph for Professionals". Drugs.com.