In fact, modern reanalysis of the path suggests that the tornado may have begun 15 miles (24 km) further west than previously thought. Appearance
Tornadoes can have a wide range of colors, depending on the environment in which they form. Those that form in dry environments can be nearly invisible, marked only by swirling debris at the base of the funnel. Condensation funnels that pick up little or no debris can be gray to white. While traveling over a body of water (as a waterspout), tornadoes can turn white or even blue. Slow-moving funnels, which ingest a considerable amount of debris and dirt, are usually darker, taking on the color of debris. Tornadoes in the Great Plains can turn red because of the reddish tint of the soil, and tornadoes in mountainous areas can travel over snow-covered ground, turning white. Lighting conditions are a major factor in the appearance of a tornado. A tornado which is "back-lit" (viewed with the sun behind it) appears very dark. The same tornado, viewed with the sun at the observers back, may appear gray or brilliant white. Tornadoes which occur near the time of sunset can be many different colors, appearing in hues of yellow, orange, and pink.Dust kicked up by the winds of the parent thunderstorm, heavy rain and hail, and the darkness of night are all factors that can reduce the visibility of tornadoes.
DNA mutational analysis revealed that the child was homozygous for a novel E64K mutation and that his mother and father were heterozygous for the novel E64K mutation. Potential causes
Smoking: Recent studies suggest that smoking can lead to marginal biotin deficiency because it speeds up biotin catabolism (especially in women). Excessive alcohol consumption
Excessive consumption of antidiuretics or inadequate levels of antidiuretic hormone
Intestinal malabsorption caused by short bowel syndrome

Biochemistry
Biotin is a coenzyme for five carboxylases in the human body (propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, pyruvate carboxylase, and 2 forms of acetyl-CoA carboxylase.) Therefore, biotin is essential for amino acid catabolism, gluconeogenesis, and fatty acid metabolism. Biotin is also necessary for gene stability because it is covalently attached to histones. Biotinylated histones play a role in repression of transposable elements and some genes. Normally, the amount of biotin in the body is regulated by dietary intake, biotin transporters (monocarboxylate transporter 1 and sodium-dependent multivitamin transporter), peptidyl hydrolase biotinidase (BTD), and the protein ligase holocarboxylase synthetase. When any of these regulatory factors are inhibited, biotin deficiency could occur. Diagnosis
The most reliable and commonly used methods for determining biotin status in the body are:

excretion of 3-hydroxyisovaleric acid and biotin in urine
activity of propionyl-CoA carboxylase in lymphocytes

Treatment
In the United States, biotin supplements are readily available without a prescription in amounts ranging from 300 to 10,000 micrograms (30 micrograms is identified as Adequate Intake). Epidemiology
Since biotin is present in many foods at low concentrations, deficiency is rare except in locations where malnourishment is very common.