Contraindications
Hypersensitivity to ergot derivatives
Pediatric patients (no clinical experience)
Severely impaired liver function or cholestasis
Concomitant use with drugs metabolized mainly by CYP450 enzymes such as erythromycin and ketoconazole, because increased plasma levels of cabergoline may result (although cabergoline undergoes minimal CYP450 metabolism). Cautions: severe cardiovascular disease, Raynauds disease, gastroduodenal ulcers, active gastrointestinal bleeding, hypotension. Side effects
Side effects are mostly dose dependent. Much more severe side effects are reported for treatment of Parkinsons disease and (off-label treatment) for restless leg syndrome which both typically require very high doses. The side effects are considered mild when used for treatment of hyperprolactinemia and other endocrine disorders or gynecologic indications where the typical dose is one hundredth to one tenth that for Parkinsons disease.Cabergoline requires slow dose titration (2–4 weeks for hyperprolactinemia, often much longer for other conditions) to minimise side effects. The extremely long bioavailability of the medication may complicate dosing regimens during titration and require particular precautions. Cabergoline is considered the best tolerable option for hyperprolactinemia treatment although the newer and less tested quinagolide may offer similarly favourable side effect profile with quicker titration times. Approximately 200 patients with newly diagnosed Parkinsons disease participated in a clinical study of cabergoline monotherapy. Seventy-six (76) percent reported at least one side effect. These side effects were chiefly mild or moderate:

GI tract: Side effects were extremely frequent. Fifty-three percent of patients reported side effects. Very frequent: Nausea (30%), constipation (22%), and dry mouth (10%). Frequent:  Gastric irritation (7%), vomiting (5%), and dyspepsia (2%).
Polysyndactyly is a hereditary anatomical malformation combining polydactyly and syndactyly. There is also a type called crossed polysyndactyly. Signs and symptoms
The way polysyndactyly presents itself varies; when the webbing is mild, it gives the appearance of the extra digit being partially connected to the (otherwise normal) digit next to it, when the webbing is extreme, the extra digit and the digit next to it will have the appearance of one rather enlarged digit (macrodactyly) and will have two or more finger/toe nails growing in the same digit (polyonychia). How the nails look will also vary, from separate supernumerary finger/toe nails to one very wide finger/toe nail. References
External links
Polysyndactyly and Marfans syndrome The case of an Egyptian Jewish family with 17 affected members. The mother also had Marfans syndrome, which she passed on to a daughter who did not have polysyndactyly.