Cataract may also present as an ocular complication associated with Sticklers Syndrome. The jelly-like substance within the eye (the vitreous humour) has a distinctive appearance in the types of Stickler syndrome associated with the COL2A1 and COL11A1 genes. As a result, regular appointments to a specialist ophthalmologist are advised. The type of Stickler syndrome associated with the COL11A2 gene does not affect the eye.People with this syndrome have problems that affect things other than the eyes and ears. Arthritis, abnormality to ends of long bones, vertebrae abnormality, curvature of the spine, scoliosis, joint pain, and double jointedness are all problems that can occur in the bones and joints. Physical characteristics of people with Stickler can include flat cheeks, flat nasal bridge, small upper jaw, pronounced upper lip groove, small lower jaw, and palate abnormalities, these tend to lessen with age and normal growth and palate abnormalities can be  treated with routine surgery. Another characteristic of this syndrome is a mild spondyloepiphyseal dysplasia which can cause reduced height.Another sign of Stickler syndrome is mild to severe hearing loss that, for some people, may be progressive (see hearing loss with craniofacial syndromes). The joints of affected children and young adults may be very flexible (hypermobile). Arthritis often appears at an early age and worsens as a person gets older.
Diagnosis
Types
Genetic changes are related to the following types of Stickler syndrome:
Stickler syndrome, COL2A1 (75% of Stickler cases)
Stickler syndrome, COL11A1
Stickler syndrome, COL11A2(non-ocular)
Stickler syndrome, COL9A1 (recessive variant)
Stickler syndrome, COL9A2 (recessive variant)
Stickler syndrome, COL9A3 (recessive variant)
Stickler Syndrome, LOX3   (Recessive, 7 cases reported)Whether there are two or three types of Stickler syndrome is controversial. Each type is presented here according to the gene involved. The classification of these conditions is changing as researchers learn more about the genetic causes. Treatment
Many professionals that are likely to be involved in the treatment of those with Sticklers syndrome, include anesthesiologists, oral and maxillofacial surgeons; craniofacial surgeons; ear, nose, and throat specialists, ophthalmologists, optometrists, audiologists, speech pathologists, occupational therapists, physical therapists and rheumatologists. History
Scientists associated with the discovery of this syndrome include:
B. David (medicine)
Gunnar B. Stickler
G. Weissenbacher
Ernst Zweymüller

See also
Mandy Haberman, invented the Haberman Feeder
Marshall syndrome
Pierre Robin syndrome

References
External links

GeneReviews/NCBI/NIH/UW entry on Stickler Syndrome