Butoconazole (trade names Gynazole-1, Mycelex-3) is an imidazole antifungal used in gynecology. It is administered as a vaginal cream. Synthesis
Reaction of epichlorohydrin with 4-Chlorobenzyl magnesium bromide leads to 1-chloro-4-(4-chlorophenyl)butan-2-ol (3). Displacement with sodium imidazole, conversion of the secondary alcohol to the chloride (SOCl2), and displacement with 2,6-dichlorobenzenethiol concludes the synthesis of the antifungal butoconazole. References
External links
"Butoconazole". Drug Information Portal. U.S. National Library of Medicine.
In pathology, dermatopathic lymphadenopathy,  is lymph node pathology due to skin disease. Cause
Also known as lipomelanotic reticulosis or Pautrier-Woringer disease, represents a rare form of benign lymphatic hyperplasia associated with most exfoliative or eczematoid inflammatory erythrodermas, including pemphigus, psoriasis, eczema, neurodermatitis, and atrophia senilis. Diagnosis
Dermatopathic lymphadenopathy is diagnosed by a lymph node biopsy. It has a characteristic pattern of histomorphology and immunohistochemical staining:

Paracortical histiocytosis
Melanin-laden macrophages
Eosinophils
Plasma cells (medulla of lymph node)

Differential diagnosis
Cutaneous T cell lymphoma
Hodgkins lymphoma
Melanoma

Treatment
The treatment is based on the underlying cause. See also
Skin disease
List of cutaneous conditions

References
External links
Dermatopathic lymphadenitis - pathconsultddx.com.