in Japan)
In the works of J. R. R. Tolkien, five wizards (Saruman, Gandalf, Radagast, Alatar and Pallando) are sent to Middle-earth to aid against the threat of the Dark Lord Sauron
In the A Song of Ice and Fire series, the War of the Five Kings is fought between different claimants to the Iron Throne of Westeros, as well as to the thrones of the individual regions of Westeros (Joffrey Baratheon, Stannis Baratheon, Renly Baratheon, Robb Stark and Balon Greyjoy)
In The Wheel of Time series, the "Emonds Field Five" are a group of five of the series main characters who all come from the village of Emonds Field (Rand alThor, Matrim Cauthon, Perrin Aybara, Egwene alVere and Nynaeve alMeara)
Myst uses the number 5 as a unique base counting system. In The Myst Reader series, it is further explained that the number 5 is considered a holy number in the fictional Dni society. Number Five is also a character in The Umbrella Academy comic book and TV series adaptation

Films
Towards the end of the film Monty Python and the Holy Grail (1975), the character of King Arthur repeatedly confuses the number five with the number three. Five Go Mad in Dorset (1982) was the first of the long-running series of The Comic Strip Presents... television comedy films
The Fifth Element (1997), a science fiction film
Fast Five (2011), the fifth installment of the Fast and Furious film series.
Other truths being actively revealed include data suggesting that the pathogen itself (i.e., chlamydia) might play an equally important role, or perhaps even more important, than the host with disease susceptibility; asymptomatic chlamydial infections might be a common cause of reactive arthritis and the two variants of reactive arthritis might respond differently to treatment in spite of the congruent clinical presentation. However, much about this syndrome remains shrouded in mystery. Recent data has been suggesting that Chlamydia-induced reactive arthritis might be a common condition that clinicians are simply failing to recognise. Therefore, an emphasis is placed on disease awareness since viable treatment options are emerging. Treatment

Balanitis circinata is one out of multiple manifestations of the reactive arthritis.Right now, topical corticosteroid therapy is the most commonly used treatment, and topical calcineurin inhibitors have also been used successfully. Newer tests on patients showed that a less harmful off-label topical treatment with the immunomodulator pimecrolimus or the immunosuppressant tacrolimus can prevent all visible symptoms of this disease. Since reactive arthritis cannot be healed as such, affected people are forced to a continuous topical treatment – otherwise they will again note first symptoms after three to four days without it.However, strong debates and controversies continue regarding the exact indications of immunomodulators like pimecrolimus and their duration of use in the absence of active controlled trials. A study released in 2015 (tested were 7,457 children with a total of 26,792 person-years) did not find any evidence that pimecrolimus could cause cancer. == References ==