The pattern of pulse abnormalities is dependent upon the classification; e.g., for type B interrupted aortic arch, the right brachial pulse will be palpable and the left brachial and femoral pulses will be impalpable due to closure of the ductus arteriosus. Rarely, an interrupted aortic arch can be associated with an intracranial aneurysm. Signs of ischemia due to interrupted aortic arch can be separated by the organ system involved:
Liver injury: elevated serum glutamic oxaloacetic transaminase (SGOT) (also known as aspartate transaminase, AST) and lactic acid dehydrogenase (LDH)
Kidney injury: elevated serum creatinine
Intestinal injury: signs of necrotizing enterocolitis, such as bloody stoolsCHARGE syndrome, a specific, rare pattern of genetic abnormalities, commonly features conotruncal and aortic arch heart defects, which can include an interrupted aortic arch. Classification
There are three primary classifications for an interrupted aortic arch, on the basis of the specific, anatomic anomaly. They are:

Type A: The aortic arch is interrupted after the left subclavian artery. Type B: The aortic arch is interrupted between the left common carotid artery and the left subclavian artery. This is the most common form of the condition, and is the classification most often associated with DiGeorge syndrome. Type C: The aortic arch is interrupted between the innominate artery and the left common carotid artery. This is the least common form of the condition.Each class can be divided into two subgroups, based upon whether the right subclavian artery originated in a normal, anatomical position (subgroup 1) or if it originated distal to the left subclavian artery and continues behind the esophagus (subgroup 2).
The classification system (Types A, B, and C) were defined by Celoria and Patton in 1959.The first successful repair of a Type A interrupted aortic arch was reported in 1961, in which the left subclavian artery was grafted into the descending thoracic aorta in a 14-year-old male patient. The first successful repair of a Type A interrupted aortic arch in an infant was in a 12-day-old infant in 1969, in which the left subclavian artery was connected to the descending thoracic aorta, the patent ductus arteriosus was closed, and the main pulmonary artery was banded.The first successful repair of a Type B interrupted aortic arch was in 1954, in which the 16 year-old, female patients own aorta was grafted from the arch to the descending thoracic aorta and the left subclavian artery was ligated. The first successful repair on a type B interrupted aortic arch in an infant was in 1973, in which a vein was used to connect the ascending aorta and the descending aorta.The first successful repair of a Type C interrupted aortic arch was in 1964, in which the 16-year-old female patients ascending aorta was grafted to the descending thoracic aorta. As of 1984, there had been no successful repairs on infants under one year old.The use of PGE1 dramatically improved the mortality rate after its introduction in 1976.