Reduction in melanin production specifically in the peripheral retina during embryonic development can trigger other symptoms such as abnormal nerve fiber projection that causes defects in neuronal migration that interrupts visual pathways and creates reduced visual acuity in the range of 20/60 to 20/400. This vision acuity is dependent upon the amount of pigmentation in the eye. Acuity is usually better in individuals with greater amounts of pigment. Aside from decreased pigment in the iris and retina, optic changes include decreased visual acuity, misrouting of the optic nerves at the chiasm, and nystagmus.OCA1 is one of the more extreme types of albinism where the iris is translucent and the eye appears pink or red in ambient light and have white skin with slight to no pigmentation when other types may have residual pigmentation. OCA1 is caused by mutations in the TYR gene, where there is a complete lack of tyrosinase activity. Genetics
The tyrosinase (TYR) gene is located on chromosome 11q14. This protein coding gene produces tyrosinase, an enzyme which catalyzes a total of three steps in the conversion of tyrosine to the end product, melanin. This enzyme and conversion process takes place within melanocytes, which are specialized cells for melanin production. Melanin is a large group of molecules that give skin, eyes, and hair their respective colors. It is also partially responsible for vision, as it protects the light sensitive portion of the eye, the retina, through absorbing light.
Oxford Textbook of Psychopathology. Oxford University Press. ISBN 978-0-19-988836-8. Lee, Kyoungmi; Kim, Hakkyun; Vohs, Kathleen D. (1 January 2011). "Stereotype Threat in the Marketplace: Consumer Anxiety and Purchase Intentions". Journal of Consumer Research. 38 (2): 343–357. CiteSeerX 10.1.1.640.678. doi:10.1086/659315. JSTOR 659315. Vohs, Kathleen D.; Baumeister, Roy F.; Chin, Jason. "Feeling Duped: Emotional, Motivational, and Cognitive Aspects of Being Exploited by Others". CiteSeerX 10.1.1.186.4833. {{cite journal}}: Cite journal requires |journal= (help)