Doxazosin, sold under the brand names Cardura among others, is a medication used to treat symptoms of benign prostatic hyperplasia (enlarged prostate) and hypertension (high blood pressure). For high blood pressure, it is a less preferred option. It is taken by mouth.Common side effects include dizziness, sleepiness, swelling, nausea, shortness of breath, and abdominal pain. Severe side effects may include low blood pressure with standing, an irregular heart beat, and priapism. It is a α1-selective adrenergic blocker in the quinazoline class of compounds.Doxazosin was patented in 1977 and came into medical use in 1988. It is available as a generic medication. In 2019, it was the 210th most commonly prescribed medication in the United States, with more than 2 million prescriptions. Medical uses
High blood pressure
Doxazosin is usually added to other antihypertensive therapy such as calcium channel antagonists, diuretics, beta-adrenoreceptor antagonists, angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers.Doxazosin is generally considered to be safe, well tolerated and effective as an add-on antihypertensive drug.Like other alpha-1 receptor antagonists, it has a role in the peri-operative management of pheochromocytoma. Benign prostatic hyperplasia
Doxazosin is considered to be effective in reducing urinary symptom scores and improving peak urinary flow in men with benign prostatic hypertrophy.
Aquarium granuloma (also known as fish tank granuloma and swimming pool granuloma) is a rare skin condition caused by a non-tubercular mycobacterium known as Mycobacterium marinum. Skin infections with M. marinum in humans are relatively uncommon, and are usually acquired from contact with contaminated swimming pools, aquariums or infected fish. Signs and symptoms
Aquarium granuloma presents as a slow-growing, inflamed red bump (nodule or plaque) at the site of infection. It is characterized by a painful, itchy skin lesion,  and may become ulcerated or crusted. Skin changes usually appear roughly three weeks after the aquatic exposure.If this condition is acquired from an aquarium, then often the dominant hand is affected. If this condition is acquired from a swimming pool, then symptoms can also develop on trauma-prone body zones, such as the elbows, knees, feet and tip of the nose. Cause
For the infection to develop in humans, the two main factors required are exposure to contaminated water, and abrasion or injury to the skin. Hence, this infection is commonly seen in individuals who clean fish tanks, handle ornamental fish and work in wet fields.Aquatic systems with a high density of fish and warm waters appear to be conditions particularly favorable to this infectious agent, and increase the changes to contract fish tank granuloma. Poor water quality and various nutritional deficiencies are also possible contributing factors.Swimming pool granuloma can occur when there is inadequate chlorination of swimming pools. Diagnosis
Aquarium granuloma is relatively nonspecific in clinical presentation.