The function of this protein is not fully understood, but it is involved in mitochondrial transport of glycine. Glycine is a substrate for ALAS2 and necessary for heme synthesis. The autosomal recessive form is typically severe in presentation. Genetic syndromes: Rarely, sideroblastic anemia may be part of a congenital syndrome and present with associated findings, such as ataxia, myopathy, and pancreatic insufficiency. Acquired clonal sideroblastic anemia
Clonal sideroblastic anemias fall under the broader category of myelodysplastic syndromes (MDS). Three forms exist and include refractory anemia with ringed sideroblasts (RARS), refractory anemia with ringed sideroblasts and thrombocytosis (RARS-T), and refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS). These anemias are associated with increased risk for leukemic evolution. Acquired reversible sideroblastic anemia
Causes include excessive alcohol use (the most common cause of sideroblastic anemia), pyridoxine deficiency (vitamin B6 is the cofactor in the first step of heme synthesis), lead poisoning and copper deficiency. Excess zinc can indirectly cause sideroblastic anemia by decreasing absorption and increasing excretion of copper. Antimicrobials that may lead to sideroblastic anemia include isoniazid (which interferes with pyridoxine metabolism), chloramphenicol (which, by inhibiting the synthesis of mitochondrial membrane protein, impairs mitochondrial respiration), cycloserine, and linezolid. Diagnosis
Ringed sideroblasts are seen in the bone marrow. On the peripheral blood smear can be found erythrocytes with basophilic stippling (cytoplasmic granules of RNA precipitates) and Pappenheimer bodies (cytoplasmic granules of iron).The anemia is moderate to severe and dimorphic. Microscopic viewing of the red blood cells will reveal marked unequal cell size and abnormal cell shape.
Siklós (Serbo-Croatian: Šikloš/Шиклош) is the 4th largest town in Baranya county, Hungary. The Malkocs Bey Mosque was built by the order of the Malkoçoğlu family. Notable people
George Mikes, British author most famous for his humorous commentaries on various countries
Albert Siklós, composer
Rudolphus de Benyovszky, violinist and composer

Twin towns – sister cities
Siklós is twinned with:
 Aiud, Romania
 Donji Miholjac, Croatia
 Feldbach, Austria
 Fornovo di Taro, Italy
 Moldava nad Bodvou, Slovakia

Gallery
References
External links
 Media related to Siklós at Wikimedia Commons

Official website in Hungarian
Castle of Siklós
Programs of Siklós
All about Siklós Card