A greater incidence of aortic aneurysm is seen in cigarette smokers; Ball had been a heavy smoker most of her life.Playwright Jonathan Larson, best known for the musical Rent, died in 1996 of an aortic dissection believed to be due to undiagnosed Marfan Syndrome. Days of Our Lives and Babylon 5 actor Richard Biggs died on May 22, 2004 at the age of 44 due to complications from aortic dissection.Lux Interior of The Cramps died at the Glendale Memorial Hospital on February 4, 2009, at the age of 62, following an aortic dissection which, contrary to initial reports about a pre-existing condition, was "sudden, shocking and unexpected".Alan Thicke died in 2016 of type-A aortic dissection at the Providence Saint Joseph Medical Center in Burbank, at the age of 69.Japanese actress Hiromi Tsuru died in her car from aortic dissection in 2017 at the age of 57.Taiwanese entertainer Alien Huang died in 2020 at the age of 36.Kentaro Miura, writer and artist of the manga Berserk, died from aortic dissection in 2021 at the age of 54.In August 2021, New Zealand cricketer Chris Cairns was put on full life support following an aortic dissection in his home in Canberra, Australia. He was transferred to Sydney, and became paralysed from the waist down due to sustaining a stroke during surgery. 41-year-old guitarist Richie Faulkner of the heavy metal band Judas Priest had an aortic aneurysm on September 27, 2021, in the middle of the final song of their 50-minute set at a music festival.
Tipranavir (TPV), or tipranavir disodium, is a nonpeptidic protease inhibitor (PI) manufactured by Boehringer Ingelheim under the trade name Aptivus  AP-tiv-əs. It is administered with ritonavir in combination therapy to treat HIV infection. Tipranavir has the ability to inhibit the replication of viruses that are resistant to other protease inhibitors and it recommended for patients who are resistant to other treatments. Resistance to tipranavir itself seems to require multiple mutations. Tipranavir was approved by the Food and Drug Administration (FDA) on June 22, 2005, and was approved for pediatric use on June 24, 2008.Tipranavir should only be taken in combination with ritonavir and other antiretroviral drugs, and is not approved for treatment-naïve patients. Like lopinavir and atazanavir, it is very potent and is effective in salvage therapy for patients with drug resistance. However, side effects of tipranavir may be more severe than those of other antiretrovirals. Some side effects include intracranial hemorrhage, hepatitis, hepatic decompensation, hyperglycemia and diabetes mellitus. The drug has also been shown to cause increases in total cholesterol and triglycerides.Aptivus labeling has a black box warning regarding hepatotoxicity and intracranial hemorrhage. References
External links
"Tipranavir". Drug Information Portal. U.S. National Library of Medicine.