A number of children diagnosed with the disorder have been born to parents who were first cousins. It can also be associated with uniparental isodisomy. Diagnosis
Treatment
Epidemiology
Fumarase deficiency is extremely rare - until around 1990 there had only been 13 diagnosed and identified cases worldwide.A cluster of 20 cases has since been documented in the twin towns of Colorado City, Arizona and Hildale, Utah, both of which were formerly known as "Short Creek" (or the Short Creek Community). The two towns combine to form a community of 10,000 members of the Fundamentalist Church of Jesus Christ of Latter Day Saints who have a history of practicing successive endogamy, or marriage within their own communities. Nicknamed "Polygamists Downs", the syndrome has been blamed on cousin marriage, but in a larger sense is related to the reproductive isolation of a community among whom 85% are blood relatives of John Y. Barlow or Joseph Smith Jessop.Since the initial cluster from FLDS communities were reported, it is now estimated that there are 100 documented cases worldwide. See also
Hereditary leiomyomatosis and renal cell cancer
Founder effect

References
Further reading
Pithukpakorn, Manop; Toro, Jorge R. (November 2, 2010) [July 31, 2006]. "Hereditary Leiomyomatosis and Renal Cell Cancer". GeneReviews. Seattle WA: University of Washington. PMID 20301430. == External links ==
Spindle cell lipoma is an asymptomatic, slow-growing subcutaneous tumor that has a predilection for the posterior back, neck, and shoulders of older men. : 625

See also
Intradermal spindle cell lipoma
List of cutaneous conditions

References


== External links ==