This involves IGL@ and c-myc.Combined, the two less-common translocations, t(2;8)(p12;q24) and t(8;22)(q24;q11), account for the remaining 15% of cases not due to the t(8;14)(q24;q32) translocation.The c-myc gene found on chromosome 8 is part of the Myc family of genes that serve as regulators of cellular transcription and is associated with Burkitt lymphoma. Expression of the c-myc gene results in the synthesis of transcriptional factors that increase the expression of other genes involved in aerobic glycolysis. Ultimately, an increase in aerobic glycolysis plays a role in providing the necessary energy for cellular growth to occur. The translocation of the c-myc gene to the IGH, IGK, or IGL region moves the gene to a location in the genome near immunoglobulin enhancers which increases the expression of the c-myc gene. Overall, this translocation leads to increased cellular proliferation that is found in Burkitt lymphoma. Point mutations can also be present in the translocated c-myc gene resulting in the expressed c-myc protein being overactive. Other mutations found include the TCF transcription factor mutation, which increases cellular proliferation via the increased expression of other genes. Along with mutations that support cell proliferation, Burkitt lymphoma has been found to also harbor mutations in the TP53 gene that is a tumor suppressor and would normally function to limit cellular growth. Virology
The complete role of EBV in the pathogenesis of endemic Burkitt lymphoma is not completely elucidated, but it has been shown to cause DNA damage, dysfunction of telomeres, and genome instability.
In anatomy, capsulitis is inflammation of a capsule.Types include:

Adhesive capsulitis of shoulder
Plica syndrome, which is an inflammation of the articular capsule of the knee joint

Adhesive capsulitis of shoulder
Adhesive capsulitis of shoulder, also known as frozen shoulder, commonly causes shoulder pain and stiffness. These sensations can be very painful and may last up to two or three years. Treatment
Manual therapy and exercise
Manual therapy involves the movement of joints and other structures by a healthcare professional such as a physiotherapist. Exercise is the movement of joints and purposeful muscle contraction. Both manual therapy and exercise are used to attempt to relieve pain and soreness and increase joint range and function. There is moderate quality evidence that manual therapy and exercise may help significantly decrease pain in patients with adhesive capsulitis of shoulder. However the study also indicates that glucocorticoid (a type of anti-inflammatory) injections were more effective. See also
Articular capsule


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