An alternative method for confirming a UHS diagnosis molecularly is by embedding UHS hairs into paraffin. Due to the atypical shape of the hair shafts in UHS, UHS hair will refract light differently than typical hair, causing a glistening effect. Treatment
Although it tends to regress naturally later in childhood, there is no definitive treatment for Uncombable Hair Syndrome. The only recommended treatment is using soft brushes and gentle conditioners. It is also recommended to avoid hair treatments that can be harsh on hair (excessive brushing, blow drying, perms, or coloring hair). Biotin supplements have also been used as a treatment, due to their historical utility in controlling nail fragility and improving hair growth after 4 months of supplementation. Epidemiology
While UHS is thought to be extremely rare, its precise frequency and prevalence is unknown. As of 2016, there were ~100 case studies of UHS in the scientific literature, and as of 2020, there are a few more documented case studies.UHS has been found in patients who also have diseases such as ectodermal dysplasia and loose anagen hair syndrome. While sometimes observed with other disorders, it is believed that Uncombable Hair Syndrome is an isolated disease. History
The syndromes name comes directly from its abnormal, frizzy appearance that “totally resists any effort to control it with brush or comb.” A possible case of uncombable hair syndrome was reported in 1912 by A.F. Le Double and F. Houssay. The syndrome was described in 1973 by A. Dupré, P. Rochiccioli, and J.L. Bonafé, who named it "cheveux incoiffables".
Rheumatoid neutrophilic dermatitis (also known as "Rheumatoid neutrophilic dermatosis") is a cutaneous condition associated with rheumatoid arthritis. See also
Sweets syndrome-like dermatosis
List of cutaneous conditions


== References ==