Society and culture
Notable people
Zion Clark, American track athlete and wrestler, 2022 Guinness World Record holder (20m hand sprint in 4.78 seconds)
Rebecca Dubber, New Zealand para-swimmer and Rio 2016 Paralympic bronze medalist
Kenny Easterday, played a fictionalized version of himself in the film Kenny
Johnny Eck, American freak show performer
Kurt Fearnley, Australian wheelchair racer
Chloé Cooper Jones, American philosopher and author
Bobby Martin, American footballer
Kevin McKee, two-times Olympic champion and two-times world champion in sledge hockey
Sainimili Naivalu, Fijian wheelchair table tennis medallist and disability rights activists
Victoria Pendergast, first female Australian sit-skier at Winter Paralympics
Jessica Rogers, American wheelchair racer and swimmer, founder and President of iSACRA (International Caudal Regression Syndrome Association)
Rose Siggins, actress (American Horror Story: Freak Show)

References


== External links ==
Adverse effects
Adverse effects of clorazepate include tolerance, dependence, withdrawal reactions, cognitive impairment, confusion, anterograde amnesia, falls in the elderly, ataxia, hangover effects, and drowsiness. It is unclear whether cognitive deficits resulting from the long-term use of benzodiazepines return to normal or persist indefinitely after withdrawal from benzodiazepines. Benzodiazepines are also known to cause or worsen depression. Paradoxical effects including excitement and paradoxical worsening of seizures can sometimes result from the use of benzodiazepines. Children, the elderly, individuals with a history of alcohol use disorder or a history of aggressive behavior and anger are at greater risk of developing paradoxical reactions to benzodiazepines.In September 2020, the U.S. Food and Drug Administration (FDA) required the boxed warning be updated for all benzodiazepine medicines to describe the risks of non-medical use, addiction, physical dependence, and withdrawal reactions consistently across all the medicines in the class. Tolerance, dependence and withdrawal
Delirium has been noted from discontinuation from clorazepate. A benzodiazepine dependence occurs in approximately one third of patients who take benzodiazepines for longer than 4 weeks, which is characterised by a withdrawal syndrome upon dose reduction. When used for seizure control, tolerance may manifest itself with an increased rate of seizures as well an increased risk of withdrawal seizures. In humans, tolerance to the anticonvulsant effects of clorazepate occurs frequently with regular use.