The criteria are:
erythema of the lips or oral cavity or cracking of the lips
rash on the trunk
swelling or erythema of the hands or feet
red eyes (conjunctival injection)
swollen lymph node in the neck of at least 15 mmMany children, especially infants, eventually diagnosed with Kawasaki disease, do not exhibit all of the above criteria. In fact, many experts now recommend treating for Kawasaki disease even if only three days of fever have passed and at least three diagnostic criteria are present, especially if other tests reveal abnormalities consistent with Kawasaki disease. In addition, the diagnosis can be made purely by the detection of coronary artery aneurysms in the proper clinical setting. Investigations
A physical examination will demonstrate many of the features listed above. Blood tests

Complete blood count may reveal normocytic anemia and eventually thrombocytosis. Erythrocyte sedimentation rate will be elevated. C-reactive protein will be elevated. Liver function tests may show evidence of hepatic inflammation and low serum albumin levels.Other optional tests include:

Electrocardiogram may show evidence of ventricular dysfunction or, occasionally, arrhythmia due to myocarditis. Echocardiogram may show subtle coronary artery changes or, later, true aneurysms. Ultrasound or computerized tomography may show hydrops (enlargement) of the gallbladder. Urinalysis may show white blood cells and protein in the urine (pyuria and proteinuria) without evidence of bacterial growth. Lumbar puncture may show evidence of aseptic meningitis.
Autoimmune optic neuropathy (AON), sometimes called autoimmune optic neuritis, may be a forme fruste of systemic lupus erythematosus (SLE) associated optic neuropathy. AON is more than the presence of any optic neuritis in a patient with an autoimmune process, as it describes a relatively specific clinical syndrome. AON is characterized by chronically progressive or recurrent vision loss associated with serological evidence of autoimmunity. Specifically, this term has been suggested for cases of optic neuritis with serological evidence of vasculitis by positive ANA, despite the lack of meeting criteria for SLE. The clinical manifestations include progressive vision loss that tends to be steroid-responsive and steroid dependent. Patients with defined SLE that go on to develop optic neuritis should be better identified as lupus optic neuritis. Signs and symptoms
AON was first described in 1982. It presents with visual loss and signs of optic nerve dysfunction, such as loss of color vision, afferent pupil defect, and sometimes abnormalities of the optic disc. The clinical features of AON can be variable and present in several unilateral or bilateral forms:

Acute anterior or retrobulbar optic neuritis sometimes associated with pain. Anterior or retrobulbar ischemic optic neuropathy not associated with pain. Chronic progressive vision loss that mimics a compressive lesion.The main features that differentiate AON from the more common typical demyelinating optic neuritis is the poor recovery of vision and the chronic or recurrent or bilateral course of AON. Furthermore, the workup for multiple sclerosis including MRI, will be negative.