Although hairy cells are technically long-lived, instead of rapidly dividing, some late-stage patients are treated with broad-spectrum chemotherapy agents such as methotrexate that are effective at killing rapidly dividing cells. This is not typically attempted unless all other options have been exhausted and it is typically unsuccessful. Prognosis
Treatment success
More than 95% of new patients are treated well or at least adequately by cladribine or pentostatin. A majority of new patients can expect a disease-free remission time span of about ten years, or sometimes much longer after taking one of these drugs just once. If retreatment is necessary in the future, the drugs are normally effective again, although the average length of remission is somewhat shorter in subsequent treatments. There is also the risk of Shingles, and Peripheral Neuropathy after treatment with cladribine. As with B-cell chronic lymphocytic leukemia, mutations in the IGHV on hairy cells are associated with better responses to initial treatments and with prolonged survival.How soon after treatment a patient feels "normal" again depends on several factors, including:

how advanced the disease was at the time of treatment;
the patients underlying health status;
whether the patient had a "complete response" or only a partial response to the treatment;
whether the patient experienced any of the rare, but serious side effects such as kidney failure;
how aggressive the individuals disease is;
whether the patient is experiencing unusual psychological trauma from the "cancer" diagnosis; and
how the patient perceived his or her pre-treatment energy level and daily functioning. Lifespan
With appropriate treatment, the overall projected lifespan for patients is normal or near-normal.
Psorosperm (from the Greek ψωρα itch and σπερμα seed) is a former name of a number of parasitic protozoa that produce cystlike or sporelike structures in the tissue of hosts. The term is now essentially obsolete. Some that affect vertebrate hosts are now called coccidia. Others, such as the cause of pébrine in silkworms, are now recognized as microsporidians, and some are myxosporidians. The genus Psorospermium (which includes the species Psorospermium haeckeli) itself is a parasite of crayfishes, and belongs to an enigmatic group of unicellular organisms that some biologists think may be related to the common ancestors of animals and fungi.J. Müller introduced the term in German (as Psorospermien) in 1841.Psorosperm was at one point believed to be the cause of Dariers disease. "Psorospermiasis" is classified under 136.4 in ICD-9. == References ==