It has been approved for use in children, adults, and the elderly, with clinically proven efficacy and safety from age one and older.Besifloxacin is available as a 0.6% ophthalmological suspension, and dosing is 3 times a day, 4 to 12 hours apart for 7 days, regardless of age or condition. Adverse effects
During the treatment, the most frequently reported ocular adverse reaction was the appearance of conjunctival redness (approximately 2% of patients). Other possible adverse reactions, reported in subjects treated with besifloxacin were: blurred vision, eye pain, eye irritation, eye pruritus and headache. == References ==
Additionally, the edema and loss of venous outflow impedes the arterial inflow. Ischemia with progression to gangrene are potential consequences. Phlegmasia alba dolens is distinguished, clinically, from phlegmasia cerulea dolens in that there is no ischemia and congestion. In severe cases of venous obstruction the arterial pulse may gradually disappear and venous gangrene may ensue. Diagnosis
The condition can be identified clinically & as early as possible to prevent further deterioration & complications like embolism, ischaemic necrosis, and gangrene. The diagnosis is confirmed with Doppler ultrasound of the veins of the affected leg, and occasionally other imaging modalities. Treatment
The mainstay of the treatment of deep vein thrombosis is with anticoagulation, but in very large DVTs various other modalities may be used to reduce the risk of complications. This may be surgical thrombectomy or catheter-directed thrombolysis. Etymology
Phlegmasia alba dolens literally means "painful white edema". It received the name "milk leg" because it was once thought to be caused by the metastasis of milk. References


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