In medicine, granulocytosis is the presence of an increased number of granulocytes in the peripheral blood. Often, the word refers to an increased neutrophil granulocyte count (neutrophilia), but granulocytosis formally refers to the combination of neutrophilia, eosinophilia, and basophilia. Leukocytosis refers to an increase in the number of all white blood cells. Causes
Granulocytosis can be a feature of a number of diseases, including:
Infection, especially bacterial
Malignancy, most notably leukemia (it is the main feature of chronic myelogenous leukemia, CML)
Autoimmune disease

Diagnosis
Diagnosis of granulocytosis is usually done by obtaining a complete blood count. Prognostic
In cardiovascular disease, increased white blood cell counts have been shown to indicate a worse prognosis. See also
Agranulocytosis
Bandemia
Complete blood count

References


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Tetany or tetanic seizure is a medical sign consisting of the involuntary contraction of muscles, which may be caused by disorders that increase the action potential frequency of muscle cells or the nerves that innervate them. Muscle cramps caused by the disease tetanus are not classified as tetany; rather, they are due to a lack of inhibition to the neurons that supply muscles. Tetanic contractions (physiologic tetanus) are a broad range of muscle contraction types, of which tetany is only one. Signs and symptoms
Tetany is characterized by contraction of distal muscles of the hands (carpal spasm with extension of interphalangeal joints and adduction and flexion of the metacarpophalangeal joints) and feet (pedal spasm) and is associated with tingling around the mouth and distally in the limbs. Causes
The usual cause of tetany is a deficiency of calcium. An excess of phosphate (high phosphate-to-calcium ratio) can also trigger the spasms. Underfunction of the parathyroid gland can lead to tetany. Low levels of carbon dioxide cause tetany by altering the albumin binding of calcium such that the ionized (physiologically influencing) fraction of calcium is reduced; one common reason for low carbon dioxide levels is hyperventilation. Low levels of magnesium can lead to tetany. Clostridium tetani toxin, via inhibition of glycine-mediated and GABA-ergic neurotransmission, may lead to tetany.An excess of potassium in grass hay or pasture can trigger winter tetany, or grass tetany, in ruminants. Osteomalacia and rickets due to deficiency of vitamin DMetabolic alkalosis with hypokalemia like Gitelman syndrome  and Bartters syndrome can cause tetany.