Memantine is a medication used to slow the progression of moderate-to-severe Alzheimers disease. It is taken by mouth.Common side effects include headache, constipation, sleepiness, and dizziness. Severe side effects may include blood clots, psychosis, and heart failure. It is believed to work by blocking NMDA receptors.Memantine was approved for medical use in the United States in 2003. It is available as a generic medication. In 2019, it was the 169th most commonly prescribed medication in the United States, with more than 3 million prescriptions. Medical use
Alzheimers disease and dementia
Memantine is used to treat moderate-to-severe Alzheimers disease, especially for people who are intolerant of or have a contraindication to AChE (acetylcholinesterase) inhibitors. One guideline recommends memantine or an AChE inhibitor be considered in people in the early-to-mid stage of dementia.Memantine has been associated with a modest improvement; with small positive effects on cognition, mood, behavior, and the ability to perform daily activities in moderate-to-severe Alzheimers disease. There does not appear to be any benefit in mild disease.Memantine when added to donepezil in those with moderate-to-severe dementia resulted in "limited improvements" in a 2017 review. The UK National Institute of Clinical Excellence (NICE) issued guidance in 2018 recommending consideration of the combination of memantine with donepezil in those with moderate-to-severe dementia. Psychiatry
Bipolar disorder
Memantine has been investigated as a possible augmentation strategy for depression in bipolar disorder but meta-analytic evidence does not support its clinical utility. Autism
Effects in autism are unclear. Adverse effects
Memantine is, in general, well tolerated.
Cutaneous endometriosis is characterized by the appearance of papules at the umbilicus or in lower abdominal scars after gynecologic surgery in middle-aged women. : 628  The size averages to 2 cm in diameter. Its colour ranges from blue to violet, brown or skin-coloured.Rarely, endometriosis may present inside the muscles of the abdominal wall instead of the skin after caesarean section. See also
Endometriosis
Skin lesion


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