Certain eunuchs, such as the Ming dynasty official Zheng He, gained immense power that occasionally superseded that of even the Grand Secretaries. Self-castration was a common practice, although it was not always performed completely, which led to it being made illegal. It is said that the justification for the employment of eunuchs as high-ranking civil servants was that, since they were incapable of having children, they would not be tempted to seize power and start a dynasty. In many cases, eunuchs were considered more reliable than the scholar-officials. As a symbolic assignment of heavenly authority to the palace system, a constellation of stars was designated as the Emperors, and, to the west of it, four stars were identified as his "eunuchs. "The tension between eunuchs in the service of the emperor and virtuous Confucian officials is a familiar theme in Chinese history. In his History of Government, Samuel Finer points out that reality was not always that clear-cut. There were instances of very capable eunuchs who were valuable advisers to their emperor, and the resistance of the "virtuous" officials often stemmed from jealousy on their part. Ray Huang argues that in reality, eunuchs represented the personal will of the Emperor, while the officials represented the alternative political will of the bureaucracy. The clash between them would thus have been a clash of ideologies or political agenda.The number of eunuchs in Imperial employ fell to 470 by 1912, when the practice of using them ceased. The last Imperial eunuch, Sun Yaoting, died in December 1996.
Eunuch priests also figured prominently in the Atargatis cult in Syria during the first centuries AD.The practice of religious castration continued into the Christian era, with members of the early church practicing celibacy (including castration) for religious purposes, although the extent and even the existence of this practice among Christians is subject to debate. The early theologian Origen found evidence of the practice in Matthew 19:10–12: "His disciples said to him, If such is the case of a man with his wife, it is better not to marry. But he said to them, Not everyone can accept this teaching, but only those to whom it is given. For there are eunuchs who have been so from birth, and there are eunuchs who have been made eunuchs by others, and there are eunuchs who have made themselves eunuchs for the sake of the kingdom of heaven. Let anyone accept this who can." (NRSV)
Tertullian, a 2nd-century Church Father, described Jesus himself and Paul of Tarsus as spadones, which is translated as "eunuchs" in some contexts. Quoting from the cited book: "Tertullian takes spado to mean virgin". The meaning of spado in late antiquity can be interpreted as a metaphor for celibacy. Tertullian even goes so far with the metaphor as to say St. Paul had been "castrated".Eunuch priests have served various goddesses from India for many centuries.