Pulmonary hyalinizing granuloma is a lesional pattern of pulmonary inflammatory pseudotumor. Pathology
Pulmonary hyalinizing granuloma is characterized by localized changes in lung architecture determined by deposition of hyaline collagenous fibrosis accompanied by sparse lymphocytic infiltrate that compresses and distorts the remaining bronchioles. A higher magnification, the mass is composed by hypocellular collagen lamellae. Associations
HIV/AIDS
Posterior uveitis
Castlemans disease


== References ==
Blue rubber bleb nevus syndrome  is a rare disorder that consists mainly of abnormal blood vessels affecting the skin or internal organs – usually the gastrointestinal tract. The disease is characterized by the presence of fluid-filled blisters (blebs) as visible, circumscribed, chronic lesions (nevi). BRBNS is caused by somatic mutations in the TEK (TIE2) gene. It was described by William Bennett Bean in 1958. Presentation
BRBNS is a venous malformation, formerly, though incorrectly, thought to be related to the hemangioma. It sometimes causes serious bleeding. Lesions are most commonly found on the skin and in the small intestine and distal large bowel. The lesions can also be found in the central nervous system, liver, and muscles. It usually presents soon after birth or during early infancy. Causes
The cause of blue rubber bleb nevus syndrome is currently unknown. The syndrome is considered sporadic. A patient who is diagnosed with BRBNS likely has a family history of other multifocal venous malformations which are a symptom of the disease. Autosomal inheritance of BRBNS has been found in familial cases associated with chromosome 9p, but the majority of cases are sporadic. The disease correlates with an onset of GI complications. It is reported that GI bleeding is the most common cause of death in most cases. Diagnosis
Blue rubber bleb nevus syndrome is difficult to diagnose because of how rare the disease is. Diagnosis is usually based on the presence of cutaneous lesions with or without gastrointestinal bleeding and/or involvement of other organs.