The subacute form causes weakness, fasciculations, cramping, and stiffness of muscles, which can lead to recumbency, as well as a stilted gait, dysphagia, ptyalism, and a weak suckle. It may be treated with selenium supplementation, but there is a 30–45% mortality rate. Other sequelae include aspiration pneumonia, failure of passive transfer, and stunting of growth. Clinical laboratory changes include evidence of rhabdomyolysis (elevated CK and AST, myoglobinuria) and low blood selenium levels. On necropsy, muscles are pale with areas of necrosis and edema evidenced as white streaks.Horses may also develop a more chronic delayed form of the disease called Neuroaxonal Dystrophy (NAD) or Equine Degenerative Myeloencephalopathy (EDM). EDM is a more severe form of NAD. The diseases are characterized by the damage and degeneration of the central nervous system. This disease process is heritable in certain breed bloodlines, such as Quarter Horse, Appaloosa, Morgan, Lusitano, and Arabian. It is hypothesized that horses develop this disease continuum because they have a defect in the uptake or utilization of Vitamin E and therefore have a higher baseline requirement. Sheep (Stiff Lamb Disease)
In lambs, the disease typically occurs between 3 and 8 weeks of age, but may occur in older lambs as well. Progressive paralysis occurs, which is evident through the following symptoms: arched back, difficulty moving and an open shouldered stance.
Laryngo-onycho-cutaneous syndrome (also known as Shabbir syndrome) is a rare epithelial disorder inherited in an autosomal recessive fashion. It is characterized by abnormalities in the larynx, nails ("onycho-"), and skin ("cutaneous"). The disorder is only found in Punjabi Muslims and only a few cases have been reported.It was characterized by Pakistani dermatologist Syed Ghulam Shabbir (1923–2002) in 1986.It may be associated with LAMA3. See also
Watson syndrome
List of cutaneous conditions

References
External links
Laryngo-onycho-cutaneous syndrome on MedlinePlus