This hypothesis is based on the findings that some but not all individuals with the disorder have abnormally high levels of one or two of the agents, alpha-1 antitrypsin and alpha-2-Macroglobulin, which inhibit the naturally occurring fibrinolytic agent, plasmin. 2) The blood of individuals has an increased ability of the pro-coagulant thrombin to bind fibrinogen and thereby promote coagulation. 3) The blood of individuals, particularly those with cryofibriognemic disease associated with other severe disorders, has high levels of immunological elements such as immunoglobulins or immune complexes that interact with fibronectin to promote blood clotting. This hypothesis is base on findings that some patients with cyrofibrinogenemic disease improve when treated with immunosuppressive drugs. Further basic research into this area is required. Asymptomatic cryofibrinogenemia
The occurrence of cryofibrinogenemia as defined by a 4 °C-induced formation of fibrinogen-based precipitation in plasma occurs in 2% to 9% of asymptomatic individuals and 8% to 13% of hospitalized patients without symptoms attributable to this precipitation. Most of these cases have relatively low levels of cold temperature-induced fibrinogen precipitate levels (<50 milligram/liter of fibrinogen) and do not have a disorder associated with the development of cryofibrinogenmia. Associated disorders
Cryoglobulinemia may occur without evidence of an underlying associated disorders, i.e. primary cryoglobulinemia (also termed essential cryoglobulinemia) or, far more commonly, with evidence of an underlying disease, i.e. secondary cryoglobulinemia. Secondary cryofibrinogenemia can develop in individuals with infection (~12% of cases), malignant or premalignant disorders (21%), vasculitis (25%), and autoimmune diseases (42%).
Smear may refer to:

A smear test, wherein a sample is smeared over a microscope slide to be studied for any pathology
A smear test usually refers to a pap test, that is, a cervical smear
Smear (card game)
Smear Lake, a lake in Wisconsin
Smear campaign, or smear job,  an attack on the reputation of an individual or group making use of disinformation tactics
Smear Campaign (album), an album by Napalm Death
Pat Smear, the guitarist and actor
Smear (optics), motion that degrades sharpness, which is generally linear over the integration time
Colloquial name for a glissando, a glide from one musical pitch to anotherSmearing may refer to:

Smearing of an image taken by an astronomical interferometer:
Bandwidth smearing, a chromatic aberration;
Time smearing, a consequence of Earth rotation during the observation;
Smearing (climbing), a technique of rock climbing
Electron smearing, a tool for improving convergence in DFT calculations

See also
Smeared, the debut studio album by Canadian rock band Sloan