Heredofamilial amyloidosis is an inherited condition that may be characterized by systemic or localized deposition of amyloid in body tissues. : 522

See also
Amyloidosis
List of cutaneous conditions


== References ==
It is unclear how a reduced amount of this protein during development leads to learning disabilities, overgrowth, and the other features of Sotos syndrome.About 95 percent of Sotos syndrome cases occur by spontaneous mutation. Most of these cases result from new mutations involving the NSD1 gene. A few families have been described with more than one affected family member. These inherited cases enabled researchers to determine that Sotos syndrome has an autosomal dominant pattern of inheritance. Diagnosis
Diagnosis is based on physical examination, looking for excessive growth among other symptoms. There are no biochemical markers for the disease. Treatment
Treatment is symptomatic. There is no standard course of treatment for Sotos syndrome. Prognosis
Sotos syndrome is not a life-threatening disorder and patients may have a normal life expectancy. Developmental delays may improve in the school-age years; however, coordination problems may persist into adulthood, along with any learning disabilities and/or other physical or mental issues. Epidemiology
Incidence is approximately 1 in 14,000 births. See also
Beckwith-Wiedemann syndrome
Perlman syndrome
Proteus syndrome

References
External links
 Media related to Sotos syndrome at Wikimedia Commons
sotos at NIH/UW GeneTests