Children with delayed puberty also display decreased academic performance in their adolescent education, but changes in academic achievement in adulthood have not been determined.There is conflicting evidence as to whether or not children with constitutional growth and pubertal delay reach their full height potential. The conventional teaching is that these children catch up on their growth during the pubertal growth spurt and just remain shorter before their delayed puberty starts. However, some studies show that these children fall short of their target height from about 4 to 11 cm. Factors that could affect final height include familial short stature and pre-pubertal growth development.Pubertal delay can also affect bone mass and subsequent development of osteoporosis. Men with delayed puberty often have low to normal bone mineral density unaffected by androgen therapy. Women are more likely to have lower bone mineral density and thus an increased risk of fractures as early as even before the onset of puberty.Furthermore, delayed puberty is correlated with a higher risk in cardiovascular and metabolic disorders in women only, but also appears to be protective for breast and endometrial in women and testicular cancer in men. See also
Developmental milestones
Endocrinology
Puberty
Constitutional growth delay
Hypogonadism
Kallmann syndrome
Turner syndrome
Klinefelter syndrome

References


== External links ==
Thus, any medication that is metabolized by the CYP3A4 enzyme will potentially have elevated levels when oral clotrimazole is used. The prescribing physician should be aware of any medication the patient is taking prior to starting oral clotrimazole. Certain medications should not be taken with oral clotrimazole. Pharmacology
Pharmacodynamics
Clotrimazole is an imidazole derivative which works by inhibiting the growth of individual Candida or fungal cells by altering the permeability of the fungal cell wall. It binds to phospholipids in the cell membrane and inhibits the biosynthesis of ergosterol and other sterols required for cell membrane production. Clotrimazole may slow fungal growth or result in fungal cell death. Sales volume
Clotrimazole is available as a generic medication, and in 2016 Canesten brand Clotrimazole was one of the biggest-selling branded over-the-counter medications sold in Great Britain, with sales of £39.2 million. References
External links
"Clotrimazole". Drug Information Portal. U.S. National Library of Medicine.