Side effects
Common adverse drug reactions (ADRs) associated with metoclopramide therapy include restlessness (akathisia), and focal dystonia. Infrequent ADRs include hypertension, hypotension, hyperprolactinaemia leading to galactorrhea, headache, and extrapyramidal effects such as oculogyric crisis.Metoclopramide may be the most common cause of drug-induced movement disorders. The risk of extrapyramidal effects is increased in people under 20 years of age, and with high-dose or prolonged therapy. Tardive dyskinesia may be persistent and irreversible in some people. The majority of reports of tardive dyskinesia occur in people who have used metoclopramide for more than three months. Consequently, the US Food and Drug Administration (FDA) recommends that metoclopramide be used for short-term treatment, preferably less than 12 weeks. In 2009, the FDA required all manufacturers of metoclopramide to issue a black box warning regarding the risk of tardive dyskinesia with chronic or high-dose use of the drug.Dystonic reactions may be treated with benzatropine, diphenhydramine, trihexyphenidyl, or procyclidine. Symptoms usually subside with diphenhydramine injected intramuscularly. Agents in the benzodiazepine class of drugs may be helpful, but benefits are usually modest and side effects of sedation and weakness can be problematic.In some cases, the akathisia effects of metoclopramide are directly related to the infusion rate when the drug is administered intravenously. Side effects were usually seen in the first 15 min after the dose of metoclopramide. Rare side effects
Diabetes, age, and female gender are risk factors that  increase  the  likelihood  of  experiencing  a  neuropsychiatric side effect of metoclopramide.
Pica or PICA may refer to:

Biology
Pica (disorder), an abnormal appetite for earth and other non-foods
Posterior inferior cerebellar artery, a major artery supplying blood to the cerebellum

Organisms
Aechmea Pica, a hybrid cultivar in the Bromeliad family of flowering plants
Pica (genus), a genus of magpie
Pika, a small mammal (archaic spelling "pica")

Organizations
OCLC PICA, a library automation company
Palestine Jewish Colonization Association, known by its Yiddish acronym as PICA
Pennsylvania Intergovernmental Cooperation Authority, a governmental agency in Philadelphia, Pennsylvania
Perth Institute of Contemporary Arts, Western Australia
Pica Press, a publishing imprint
Pittsburgh Intergovernmental Cooperation Authority, a governmental agency in Pittsburgh, Pennsylvania
Portland Institute for Contemporary Art, Oregon

People
Antonio Pica (1923–2014), Spanish actor
Joe Pica (1923–1973), American pianist
Pierre Pica (born 1951), French linguist
Teresa P. Pica (1945–2011), American educator
Tina Pica (1884–1968), Italian actress
Yamantaka Eye (born 1964), Japanese artist known as DJ Pica Pica Pica (DJ 光光光)

Places
Pica, Chile, an oasis town in the Atacama Desert of Chile
Limón de Pica, a lime variety from Pica
Pica, Cumbria, a village in northwest England
Pica, Jayuya, Puerto Rico, a barrio

Technology
Acer PICA, a system logic chipset introduced in 1993
Phenolic-impregnated carbon ablator, a spacecraft heat shield material
Pre-integrated COF APM, part of the International Space Stations Columbus module systems

Other uses
Pica, an alternative name for the grape Merille
Pica, a lance used by a picador in bullfighting
Pica (typography), a unit of length used in typesetting and document layout
píča, a rude expression for a vagina in the Czech Republic and Slovakia

See also
Pico (disambiguation)
Piga (disambiguation)
Pika (disambiguation)