Allergies
Diphenhydramine is effective in treatment of allergies. As of 2007, it was the most commonly used antihistamine for acute allergic reactions in the emergency department.By injection it is often used in addition to epinephrine for anaphylaxis, although as of 2007 its use for this purpose had not been properly studied. Its use is only recommended once acute symptoms have improved. Topical formulations of diphenhydramine are available, including creams, lotions, gels, and sprays. These are used to relieve itching and have the advantage of causing fewer systemic effects (e.g., drowsiness) than oral forms. Movement disorders
Diphenhydramine is used to treat akathisia and Parkinsons disease–like extrapyramidal symptoms caused by antipsychotics. It is also used to treat acute dystonia including torticollis and oculogyric crisis caused by first generation antipsychotics. Sleep
Because of its sedative properties, diphenhydramine is widely used in nonprescription sleep aids for insomnia. The drug is an ingredient in several products sold as sleep aids, either alone or in combination with other ingredients such as acetaminophen (paracetamol) in Tylenol PM or ibuprofen in Advil PM. Diphenhydramine can cause minor psychological dependence. Diphenhydramine has also been used as an anxiolytic.Diphenhydramine has also been used off prescription by parents in an attempt to make their children sleep or remain sedated on long-distance flights.
Chalicosis is a form of pneumoconiosis affecting the lungs or bronchioles, found chiefly among stonecutters. The disease is caused by the inhalation of fine particles of stone. The term is from Greek, χάλιξ, gravel. References


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