The athlete Tim Howard, described by the Chicago Tribune as the "rarest of creatures—an American soccer hero", and by the Tourette Syndrome Association as the "most notable individual with Tourette Syndrome around the world", says that his neurological makeup gave him an enhanced perception and an acute focus that contributed to his success on the field.Samuel Johnson is a historical figure who likely had Tourette syndrome, as evidenced by the writings of his friend James Boswell. Johnson wrote A Dictionary of the English Language in 1747, and was a prolific writer, poet, and critic. There is little support for speculation that Mozart had Tourettes: the potentially coprolalic aspect of vocal tics is not transferred to writing, so Mozarts scatological writings are not relevant; the composers available medical history is not thorough; the side effects of other conditions may be misinterpreted; and "the evidence of motor tics in Mozarts life is doubtful".Likely portrayals of TS or tic disorders in fiction predating Gilles de la Tourettes work are "Mr. Pancks" in Charles Dickenss Little Dorrit and "Nikolai Levin" in Leo Tolstoys Anna Karenina. The entertainment industry has been criticized for depicting those with Tourette syndrome as social misfits whose only tic is coprolalia, which has furthered the publics misunderstanding and stigmatization of those with Tourettes. The coprolalic symptoms of Tourettes are also fodder for radio and television talk shows in the US and for the British media.
Mitotane, sold under the brand name Lysodren, is a steroidogenesis inhibitor and cytostatic antineoplastic medication which is used in the treatment of adrenocortical carcinoma and Cushings syndrome. It is a derivative of the early insecticide DDT and an isomer of p,p-DDD (4,4-dichlorodiphenyldichloroethane) and is also known as 2,4-(dichlorodiphenyl)-2,2-dichloroethane (o,p-DDD). Medical uses
Mitotane has been produced by Bristol Myers Squibb but it is marketed as an orphan drug for adrenocortical carcinoma due to the small number of patients in need of it. Its main use is in those patients who have persistent disease despite surgical resection, those who are not surgical candidates, or those who have metastatic disease. In a 2007 retrospective study of 177 patients from 1985 to 2005 showed a significant increase in the recurrence-free interval after radical surgery followed by mitotane when compared to surgery alone. The drug is also sometimes used in the treatment of Cushings syndrome. Side effects
The use of mitotane is unfortunately limited by side effects, which, as reported by Schteinberg et al., include anorexia and nausea (88%), diarrhea (38%), vomiting  (23%), decreased memory and ability to concentrate (50%), rash (23%), gynecomastia (50%), arthralgia (19%), and leukopenia (7%). Pharmacology
Pharmacodynamics
Mitotane is an inhibitor of the adrenal cortex. It acts as an inhibitor of cholesterol side-chain cleavage enzyme (P450scc, CYP11A1), and also of 11β-hydroxylase (CYP11B1), 18-hydroxylase (aldosterone synthase, CYP11B2), and 3β-hydroxysteroid dehydrogenase (3β-HSD) to a lesser extent.