Aliskiren/hydrochlorothiazide, sold under the brand name Tekturna HCT among others, is a fixed-dose combination medication for the treatment of hypertension (high blood pressure). It contains aliskiren, a renin inhibitor, and hydrochlorothiazide, a diuretic. It is taken by mouth.The most common side effect is diarrhea.Aliskiren/hydrochlorothiazide was approved for medical use in the United States in January 2008, and for use in the European Union in January 2009. Medical uses
Aliskiren/hydrochlorothiazide is indicated for the treatment of essential hypertension in adults. References
External links
"Aliskiren hemifumarate mixture with hydrochlorothiazide". Drug Information Portal. U.S. National Library of Medicine.
If Smokers melanosis is destroyed by excessive smoking, as in the hard palate of reverse smokers, who smoke with the glowing part of the cigarette inside the mouth for different reasons, a pale depigmented surface is first seen, indicating the loss of the protecting melanin. Then a red inflammation sometimes occurs and cancer development may follow. In reverse smokers it is important to regularly inspect the  areas with Smokers melanosis to detect any melanin destruction, in order to stop smoking in time and thus prevent a cancer to develop. Epidemiology
A study in Sweden showed that 21.5% of smokers and 3% of nonsmokers (genetic pigmentation or unknown cause) had lesions that could be classified as an oral melanin pigmentation. A gingival melanin index in 4 degrees was established. Already with a consumption of 1-3 cigarettes a day 9.3% of all 20.333 examined showed a smokers melanosis. Pipe smokers had smokers melanosis in 16.8%. One year after the start of cigarette smoking a clinically visible smokers melanosis could be seen in 12.3% of women, and 17% among men. In cigarette smokers who quit smoking, the number of individuals with smokers melanosis becomes slowly less frequent after 2–3 months, but can still be seen in a few former smokers three years after smoking stop. Although clinically visible genetic melanin pigmentations in the mouth are present in several ethnic groups all over the world, more mucosal areas will be melanin-pigmentet if tobacco products are used.