When viewing an Amsler grid, some straight lines appear wavy and some patches appear blank
When viewing a Snellen chart, at least 2 lines decline
In dry macular degeneration, which occurs in 85–90 percent of AMD cases, drusen spots can be seen in Fundus photography
Using an electroretinogram, points in the macula with a weak or absent response compared to a normal eye may be found
Farnsworth-Munsell 100 hue test and Maximum Color Contrast Sensitivity test (MCCS) for assessing color acuity and color contrast sensitivity
Optical coherence tomography is now used by most ophthalmologists in the diagnosis and the follow-up evaluation of the response to treatment with antiangiogenic drugs.Diagnosis of wet (or late stage) AMD may include the following in addition to the above tests:

Preferential hyperacuity perimetry changes (for wet AMD). Preferential hyperacuity perimetry is a test that detects drastic changes in vision and involves the macula being stimulated with distorted patterns of dots and the patient identification of where in the visual field this occurs. In wet macular degeneration, angiography can visualize the leakage of bloodstream behind the macula. Fluorescein angiography allows for the identification and localization of abnormal vascular processes. Histology
Pigmentary changes in the retina –  In addition to the pigmented cells in the iris (the colored part of the eye), there are pigmented cells beneath the retina.
Lipoprotein lipase deficiency  is a genetic disorder in which a person has a defective gene for lipoprotein lipase, which leads to very high triglycerides, which in turn causes stomach pain and deposits of fat under the skin, and which can lead to problems with the pancreas and  liver, which in turn can lead to diabetes. The disorder only occurs if a child acquires the defective gene from both parents (it is  autosomal recessive). It is managed by restricting fat in diet to less than 20 g/day. Signs and symptoms
The disease often presents in infancy with colicky pain, failure to thrive, and other symptoms and signs of the chylomicronemia syndrome. In women the use of estrogens or first pregnancy are also well known trigger factors for initial manifestation of LPLD. At all ages, the most common clinical manifestation is recurrent abdominal pain and acute pancreatitis. The pain may be epigastric, with radiation to the back, or it may be diffuse, with the appearance of an emergent acute abdomen. Other typical symptoms are eruptive xanthomas (in about 50% of patients), lipaemia retinalis and hepatosplenomegaly. Complications
Patients with LPLD are at high risk of acute pancreatitis, which can be life-threatening, and can lead to chronic pancreatic insufficiency and diabetes. Diagnosis
Lab tests show massive accumulation of chylomicrons in the plasma and corresponding severe hypertriglyceridemia. Typically, the plasma in a fasting blood sample appears creamy (plasma lactescence).Familial LPL deficiency should be considered in anyone with severe hypertriglyceridemia and the chylomicronemia syndrome.