Early symptoms may also include:
Eyes that appear to gaze downward
Irritability
Seizures
Separated sutures
Sleepiness
VomitingSymptoms that may occur in older children can include:
Brief, shrill, high-pitched cry
Changes in personality, memory, or the ability to reason or think
Changes in facial appearance and eye spacing (craniofacial disproportion)
Crossed eyes or uncontrolled eye movements
Difficulty feeding
Excessive sleepiness
Headaches
Irritability, poor temper control
Loss of bladder control (urinary incontinence)
Loss of coordination and trouble walking
Muscle spasticity (spasm)
Slow growth (child 0–5 years)
Delayed milestones
Failure to thrive
Slow or restricted movement
VomitingBecause hydrocephalus can injure the brain, thought and behavior may be adversely affected. Learning disabilities, including short-term memory loss, are common among those with hydrocephalus, who tend to score better on verbal IQ than on performance IQ, which is thought to reflect the distribution of nerve damage to the brain. Hydrocephalus that is present from birth can cause long-term complications with speech and language. Children can have issues such as nonverbal learning disorder, difficulty understanding complex and abstract concepts, difficulty retrieving stored information, and spatial/perceptual disorders. Children with hydrocephalus are often known in having the difficulty in understanding the concepts within conversation and tend to use words they know or have heard. However, the severity of hydrocephalus can differ considerably between individuals, and some are of average or above-average intelligence. Someone with hydrocephalus may have coordination and visual problems, or clumsiness. They may reach puberty earlier than the average child (this is called precocious puberty). About one in four develops epilepsy. Cause
Congenital
Congenital hydrocephalus is present in the infant prior to birth, meaning the fetus developed hydrocephalus in utero during fetal development.
Elderly users of diflunisal are at greater risk for serious GI events. Increased risk of GI events including bleeding, ulceration, and stomach or intestine perforation. Abdominal pain or cramps
Constipation
Gas
Diarrhea
Nausea and vomiting
Dyspepsia

Cardiovascular
Irregular heart beat
Possible increased risk of serious and potentially fatal cardiovascular thrombotic events, MI, and stroke
Risks may increase with duration of use and for cardiovascular disease history

Ear, nose, throat, and eye
Ringing in the ears
Yellowing of eyes

Central nervous system
Drowsiness
Dizziness
Headache
Insomnia
Fatigue
Somnolence
Nervousness

Skin
Swelling of the feet, ankles, lower legs, and hands
Yellowing of skin
Rash
Ecchymosis

Contraindications
Hypersensitivity to aspirin/NSAID-induced asthma or urticaria
Aspirin triad
3rd trimester pregnancy
Coronary artery bypass surgery (peri-op pain)

Cautions
Overdose
Deaths that have occurred from diflunisal usually involved mixed drugs and or extremely high dosage. The oral LD50 is 500 mg/kg. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams. Mixed with other medicines, a death at 7.5 grams has also occurred. Diflunisal usually comes in 250 or 500 mg, making it relatively hard to overdose by accident. References
External links
Diflunisal: MedlinePlus Drug Information
Dolobid Prescribing Information (manufacturers website)
Dolobid Medication Guide (manufacturers website)
"Single dose oral diflunisal for acute postoperative pain in adults"