Bezoars were important objects in cabinets of curiosity and natural history collections, mainly for their use in early modern pharmacy and the study of animal health.The Merck Manual of Diagnosis and Therapy notes that consumption of unripened persimmons has been identified as the main cause of epidemics of intestinal bezoars, and that up to 90 percent of bezoars that occur from excessive consumption require surgery for removal.A 2013 review of three databases identified 24 publications presenting 46 patients treated with Coca-Cola for phytobezoars. The cola was administered in doses of 500 ml (18 imp fl oz; 17 US fl oz) to up to 3,000 ml (110 imp fl oz; 100 US fl oz) over 24 hours, orally or by gastric lavage. A total of 91.3% of patients had complete resolution after treatment with Coca-Cola: 50% after a single treatment, with others requiring the cola plus endoscopic removal. Doctors resorted to surgical removal in four cases. See also
Bezoardicum
Coca-Cola treatment of phytobezoars
Enterolith
Fecalith
Gastrolith
Goa stone
Gorochana
List of English words of Persian origin
Regurgitalith
Snake-stones
Toadstone

References
Bibliography
Barry Levine. 1999. Principles of Forensic Toxicology. Amer. Assoc. for Clinical Chemistry. ISBN 1-890883-87-5. Martín-Gil FJ, Blanco-Ávarez JI, Barrio-Arredondo MT, Ramos-Sanchez MC, Martin-Gil J. Jejunal bezoar caused by a piece of apple peel – Presse Med, 1995 Feb. 11; 24(6):326. The Poison Sleuths: Arsenic – The King of Poisons. Retrieved March 10, 2007. (This webpage is a reprint by the author of an article originally published in the 1997 issue of Science Reporter, published by the National Institute of Science Communication (CSIR) in India.)
In 1952, the first documented case outside North or Central America, in Tunisia, was reported. The 1950s also saw the first introduction of antifungal drugs including amphotericin B. Before 1950, the fatality rate for disseminated blastomycosis was 92%, and treatment options were limited to iodide compounds, radiation therapy, and surgery. The first azole antifungal drug, ketoconazole, was developed in the 1970s and approved in the United States in 1981.Prior to 2013, the only species known to cause blastomycosis was B. dermatitidis. Since that time, genomic analysis has identified multiple other Blastomyces species causing blastomycosis, including B. gilchristii (2013), B. helicus (reassigned from the genus Emmonsia in 2017), B. percursus (2017), and B. emzantsi (2020). Other animals
Blastomycosis affects a broad range of mammals. As with humans, most animals that become infected were formerly healthy and immunocompetent. Dogs are frequently affected; blastomycosis is eight to ten times more common in dogs than in humans. Sporting and hound breeds are at the greatest risk. Cats and horses can also be infected. Cats with feline immunodeficiency virus are particularly at risk. However, the overall risk of blastomycosis in cats is 28 to 100 times lower than in dogs. Cases of blastomycosis have also been reported in captive lions and tigers, in a wild North American black bear, and in marine mammals such as the Atlantic bottlenose dolphin.The nonspecific symptoms that make blastomycosis difficult to diagnose in humans also complicate veterinary diagnosis. Cats in particular are often only diagnosed after death.Dogs and humans frequently acquire blastomycosis from the same exposure event.