Laser therapy is painful, requires anaesthesia, and has risks of scarring and dyspigmentation. Prognosis
The prognosis for individuals with TSC depends on the severity of symptoms, which range from mild skin abnormalities to varying degrees of learning disabilities and epilepsy to severe intellectual disability, uncontrollable seizures, and kidney failure. Those individuals with mild symptoms generally do well and live long, productive lives, while individuals with the more severe form may have serious disabilities. However, with appropriate medical care, most individuals with the disorder can look forward to normal life expectancy.A study of 30 TSC patients in Egypt found, "...earlier age of seizures commencement (<6 months) is associated with poor seizure outcome and poor intellectual capabilities. Infantile spasms and severely epileptogenic EEG patterns are related to the poor seizure outcome, poor intellectual capabilities and autistic behavior. Higher tubers numbers is associated with poor seizure outcome and autistic behavior. Left-sided tuber burden is associated with poor intellect, while frontal location is more encountered in ASD [autism spectrum disorders]. So, close follow up for the mental development and early control of seizures are recommended in a trial to reduce the risk factors of poor outcome. Also early diagnosis of autism will allow for earlier treatment and the potential for better outcome for children with TSC. "Leading causes of death include renal disease, brain tumour, lymphangioleiomyomatosis of the lung, and status epilepticus or bronchopneumonia in those with severe intellectual disability. Cardiac failure due to rhabdomyomas is a risk in the fetus or neonate but is rarely a problem subsequently.
Symptoms
Sheep
Infected sheep experience sunburn at face, ears, teats and vulva. It is the primary symptom of the poisoning caused by sporidesmin. The sunburn is caused by the fact that the lower tissue is swollen. The skin gets crusty, dark and then peels,. making it susceptible to infection. Other symptoms include dullness, weakness, inappetence, and ill-thrift. An affection of the liver results in jaundice. In a worst-case, the sheep die. Cattle
Infected cattle suffer from sunburn. Dark pigmented skin is often affected. Cattle produce less milk. Jaundice is possible and death after some months. Treatment
Convalescence can take a long time, but some animals may not get healthy. External therapy is possible to treat the sunburn. Animals could be protected by the intake of zinc. Zinc reacts with sporidesmin to create a metallic complex, so that the poison can be eliminated from the body. Prevention and control
If animals are sunburned, they should be placed in the stable to protect them from sunlight. Infected cattle should no longer be used in milk production.Reduce flock density (0.45 hectare/ 15 cows or 100 sheep)GGT (enzyme) is released by the damaged liver over the course of this disease and can be tested to indicate disease severity. == References ==