A paradigm shift to a non-nucleic infectious entity was required when the results were validated with an explanation of how a prion protein might transmit spongiform encephalopathy. Not until 1988 was the neuropathology of spongiform encephalopathy properly described in cows. The alarming amplification of BSE in the British cattle herd heightened fear of transmission to humans and reinforced the belief in the infectious nature of TSE. This was confirmed with the identification of a Kuru-like disease, called new variant Creutzfeldt–Jakob disease, in humans exposed to BSE. Although the infectious disease model of TSE has been questioned in favour of a prion transplantation model that explains why cannibalism favours transmission, the search for a viral agent was, as of 2007, being continued in some laboratories. References
This entry incorporates public domain text originally from the National Institute of Neurological Disorders and Stroke, National Institutes of Health [1] and the U.S. National Library of Medicine [2]

External links

Transmissible spongiform encephalopathy at Curlie
Phacodonesis (; from Ancient Greek  φακός (phakos) lens, and  δονέω (doneo) to shake) is the tremulousness or vibration of the lens with eye movement. This is often due to lens subluxation, the incomplete or partial dislocation of the lens, caused by an injury to the eye in which some or most of the zonular fibers are broken. See also
Iridodonesis

References
External links
An example of phacodonesis on YouTube