These were halted after the death of Jesse Gelsinger, a young man taking part in a phase I trial using an adenovirus vector. Currently, the only option for curing OTC deficiency is a liver transplant, which restores normal enzyme activity. A 2005 review of 51 patients with OTC deficiency who underwent liver transplant estimated 5-year survival rates of greater than 90%. Severe cases of OTC deficiency are typically evaluated for liver transplant by 6 months of age. Prognosis
A 1999 retrospective study of 74 cases of neonatal onset found that 32 (43%) patients died during their first hyperammonemic episode. Of those who survived, less than 20% survived to age 14. Few of these patients received liver transplants. References
External links
http://www.nucdf.orghttp://www.otcdeficiency.com
Phoria are an English art rock band based in Brighton, consisting of Trewin Howard, Ed Sanderson, Jeb Hardwick, James "Cheese" Cheeseman, and Seryn Burden. Phoria released their debut EP, Yourself Still, in 2010, followed by Bloodworks (2013) and Display (2014). The records earned the band international critical and popular acclaim. The bands first full-length album, Volition, was released on 3 June 2016. Their second album, Caught a Black Rabbit, came out on 13 November 2020. Biography
Phoria members Trewin, Jeb and Ed went to primary as school together in Salisbury, where they learned cello, classical guitar, and violin respectively. As friends, they spent their youth making music together before leaving for university in 2005. Jeb and Ed both attended the University of Southampton. Ed continued to study music, specialising in violin and piano. Jeb studied for a sociology degree, though spent much of his time experimenting with music and visual arts. Trewin attended the Dartington College of Arts in Devon. He  had initially enrolled on as fine arts course but was soon drawn back to music. Having completed their studies, Trewin, Ed, and Jeb returned to Salisbury and took full time jobs. Jebs included a brief spell as an insurance agent. Ed, with a passion for acting, took large but unfulfilling parts in a series of niche-market films. It was not long before the three of them realised that their future lay elsewhere, and moved to Brighton to start their musical careers.