hypothyroidism)
Insufficient or poor-quality sleep
Limited physical exercise and a sedentary lifestyle
Poor nutrition
Metabolic disorders, which could be caused by repeated attempts to lose weight by weight cycling
Overeating
Psychotropic medication (e.g. olanzapine)
Smoking cessation and other stimulant withdrawal
StressPeople who have insulin dependent diabetes and chronically overdose insulin may gain weight, while people who already are overweight may develop insulin tolerance, and in the long run develop type II diabetes. Treatment
The usual treatments for overweight individuals is diet and physical exercise. Dietitians generally recommend eating several balanced meals dispersed through the day, with a combination of progressive, primarily aerobic, physical exercise. In fact, some research found benefits from physical activity, diet and behaviour changes on BMI in children from 12 to 17 years old.Considering that most of the treatment strategies are directed to change lifestyle-related behaviours of individuals (namely in dietary and physical activity), the transtheoretical model (TTM) has been used as a framework to design weight management interventions. A systematic review assessed the effectiveness of dietary and physical activity interventions based on the TTM in producing sustainable (one year or longer) weight loss in overweight and obese adults. The included studies did not allow to produce conclusive evidence about the impact of the use of this model combined with these interventions on sustainable weight loss. Nevertheless, very low quality scientific evidence suggests that this approach may lead to improvements in physical activity and dietary habits, namely increased in both exercise duration and frequency, and fruits and vegetables consumption, along with reduced dietary fat intake.
Hereditary pyropoikilocytosis (HPP) is an autosomal recessive form of hemolytic anemia characterized by an abnormal sensitivity of red blood cells to heat and erythrocyte morphology similar to that seen in thermal burns or from prolonged exposure of a healthy patients blood sample to high ambient temperatures. Patients with HPP tend to experience severe hemolysis and anemia in infancy that gradually improves, evolving toward typical elliptocytosis later in life. However, the hemolysis can lead to rapid sequestration and destruction of red cells. Splenectomy is curative when this occurs. HPP has been associated with a defect of the erythrocyte membrane protein spectrin and with spectrin deficiency. It was characterized in 1975. It is considered a severe form of hereditary elliptocytosis. Causes
Mutations of the alphaspectrin gene causes this disease. HPP can be considered as a subset of hereditary elliptocytosis. Diagnosis
Genetic testing for the presence of mutations in protein molecules is considered to be a confirmatory testing technique. It is important to know the risks regarding the transmission and dangers of HPP. Treatment
Splenectomy is a possible treatment

See also
Erythrocyte
Poikilocytosis
List of hematologic conditions

References


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