Remifentanil  is a potent, short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct to an anaesthetic. Remifentanil is used for sedation as well as combined with other medications for use in general anesthesia. The use of remifentanil has made possible the use of high-dose opioid and low-dose hypnotic anesthesia, due to synergism between remifentanil and various hypnotic drugs and volatile anesthetics. Clinical use
Remifentanil is used as an opioid analgesic that has a rapid onset and rapid recovery time. It has been used effectively during craniotomies, spinal surgery, cardiac surgery, and gastric bypass surgery. While opiates function similarly, with respect to analgesia, the pharmacokinetics of remifentanil allows for quicker post-operative recovery. Administration
It is administered in the form remifentanil hydrochloride and in adults is given as an intravenous infusion in doses ranging from 0.1 microgram per kilogram per minute to 0.5 (µg/kg)/min. Children may require higher infusion rates (up to 1.0 (µg/kg)/min). The clinically useful infusion rates are 0.025–0.1 (µg/kg)/min for sedation (rates adjusted to age of patient, severity of their illness and invasiveness of surgical procedure). Small amounts of other sedative medications are usually co-administered with remifentanil to produce sedation. Clinically useful infusion rates in general anesthesia vary but are usually 0.1–1 (µg/kg)/min.Remifentanil can be administered as part of an anesthesia technique called TIVA (total intravenous anesthesia) using computer controlled infusion pumps in a process called target controlled infusion (TCI).
Parentheses indicate location in body

LigamentsAnterior cruciate ligament (knee), medial collateral ligament (knee), ulnar collateral ligaments (wrist/hand), interspinous ligaments (vertebrae)MusclesBiceps brachii (upper arm), rectus femoris (thigh), transverse abdominis (abdominals)TendonsPatellar tendon (knee), calcaneal/Achilles tendon (foot/lower leg), biceps tendon (shoulder/elbow)NervesBrachial plexus (shoulder), ulnar nerve (elbow/hand), peroneal nerve (ankle/foot), cranial nerves I-XII(head)BonesFemur (leg), humerus (arm), ribs (torso), metatarsals I-VI (foot), metacarpals I-VI (hand)CartilageMenisci (knee), intervertebral discs (spine), acetabulum (hip)

Management
RICE method
The RICE method is an effective procedure used in the initial treatment of a soft tissue injury. Rest
It is suggested that the patient take a break from the activity that caused the injury in order to give the injury time to heal. Ice
The injury should be iced on and off in 20 minute intervals, avoiding direct contact of the ice with the skin. Compression
Bandaging the injury will compress it, and prevent any further bleeding or swelling from occurring. Elevation
Elevating the injury above the heart while resting will aid in the reduction of swelling. No HARM protocol
This mnemonic indicates what  not  to do within the first 48–72 hours after the injury in order to speed up the recovery process. Heat
Applying heat to the injured area can cause blood flow and swelling to increase. Alcohol
Alcohol can inhibit the ability to feel if the injury is becoming more aggravated, as well as increasing blood flow and swelling. Re-injury
Avoid any activities that could aggravate the injury and cause further damage. Massage
Massaging an injured area can promote blood flow and swelling, and potentially cause more damage if done too early.