Once the fistula tract is in a low enough position it may be laid open to speed up the process, or the seton can remain in place until the fistula is completely cured. This was the traditional modality used by physicians in Ancient Egypt and formally codified by Hippocrates, who used horsehair and linen. Seton stitch –  a length of suture material looped through the fistula which keeps it open and allows pus to drain out. In this situation, the seton is referred to as a draining seton. The stitch is placed close to the ano-rectal ring – which encourages healing and makes further surgery easy. Fistulotomy – till anorectal ring
Colostomy – to allow healing
Fibrin glue injection is a method explored in recent years, with variable success. It involves injecting the fistula with a biodegradable glue which should, in theory, close the fistula from the inside out, and let it heal naturally. This method is perhaps best tried before all others since, if successful, it avoids the risk of incontinence, and creates minimal stress for the patient. Fistula plug involves plugging the fistula with a device made from small intestinal submucosa. The fistula plug is positioned from the inside of the anus with suture. According to some sources, the success rate with this method is as high as 80%. As opposed to the staged operations, which may require multiple hospitalizations, the fistula plug procedure requires hospitalization for only about 24 hours.
Cardiospondylocarpofacial syndrome is a very rare genetic disorder which is characterized by cardiac, digital, osseous anomalies with facial dysmorphisms

Signs and symptoms
The following is a list of the symptoms most commonly exhibited:
Variable vertebral anomalies
Brachydactyly
Conductive hearing loss
High palate
Mitral regurgitation
Mitral valve prolapse
Short stature, nearing dwarfism
Short palms
Carpal bone synostosisLess common symptoms include:

Failure for permanent teeth to erupt
Teeth misalignment
Horseshoe kidney
Dentition anomalies
Ocular anomalies
Nostril anteversion
Epiphysis in the shape of a cone
Congenital hearing loss
Decresed testes size (males)
Skeletal maturation delay
Feeding difficulties
Freckles
Apple cheeks
Gastroesophageal reflux
Hypertelorism
Joint hypermobility
Long philtrum
Rotated ears
Pseudoepiphyses
High frequency of middle ear infections
Rib synostosis
Scoliosis
Small foot
Strabismus
Tarsal synostosis
Telecanthus
Upslanted parpebral fissures
Broad nasal bridge
Vesicoureteral reflux

Causes
It is caused by autosomal dominant mutations of the MAP3K7 gene in the long arm of chromosome 6. Epidemiology
Only 12 cases worldwide have been described in medical literature. == References ==