At birth, infants have relatively high levels of AFP, which fall to normal adult levels by the second year of life. The normal level for AFP in children has been reported as lower than 50 nanograms per milliliter (ng/ml) and 10 ng/ml in adults. An AFP level greater than 500 ng/ml is a significant indicator of hepatoblastoma. AFP is also used as an indicator of treatment success. If treatments are successful in removing the cancer, the AFP level is expected to return to normal. Treatment
Surgical removal of the tumor, neoadjuvant chemotherapy prior to tumor removal, and liver transplantation have been used to treat these cancers. Primary liver transplantation provides high, long term, disease-free survival rate in the range of 80%, in cases of complete tumor removal and adjuvant chemotherapy survival rates approach 100%. The presence of metastases is the strongest predictor of a poor prognosis. References
External links
humpath #2775 (Pathology images)
Calcipotriol, also known as calcipotriene, is a synthetic derivative of calcitriol, a form of vitamin D.  It is used in the treatment of psoriasis. It is safe for long-term application in psoriatic skin conditions.It was patented in 1985 and approved for medical use in 1991. It is marketed under the trade name "Dovonex" in the United States, "Daivonex" outside North America, and "Psorcutan" in Germany.It is on the World Health Organizations List of Essential Medicines.Calcipotriol is also available as Calcipotriol/betamethasone dipropionate, a fixed-dose combination medication with the synthetic corticosteroid betamethasone dipropionate for the treatment of plaque psoriasis. Medical uses
Chronic plaque psoriasis is the chief medical use of calcipotriol. It has also been used successfully in the treatment of alopecia areata. Contraindications
Hypersensitivity, use on face, hypercalcaemia, or evidence of vitamin D toxicity are the only contraindications for calcipotriol use.Cautions include exposure to excessive natural or artificial light, due to the potential for calcipotriol to cause photosensitivity. Adverse effects
Adverse effects by frequency:
Very common (> 10% frequency)
Burning
Itchiness
Skin irritationCommon (1–10% frequency)

Uncommon (0.1–1% frequency)
Exacerbation of psoriasisRare (< 0.1% frequency)

Interactions
No drug interactions are known. Pharmacology
Mechanism of action
The efficacy of calcipotriol in the treatment of psoriasis was first noticed by the observation of patients receiving various forms of vitamin D in an osteoporosis study. Unexpectedly, some patients who also had psoriasis experienced dramatic reductions in lesion counts.The precise mechanism of calcipotriol in remitting psoriasis is not well understood.