If the cause is spondylolisthesis or spinal stenosis, surgery appears to provide pain relief for up to two years. Alternative medicine
Low to moderate-quality evidence suggests that spinal manipulation is an effective treatment for acute sciatica. For chronic sciatica, the evidence supporting spinal manipulation as treatment is poor. Spinal manipulation has been found generally safe for the treatment of disc-related pain; however, case reports have found an association with cauda equina syndrome, and it is contraindicated when there are progressive neurological deficits. Prognosis
About 39% to 50% of people with sciatica still have symptoms after one to four years. In one study, around 20% were unable to work at their one-year followup, and 10% had had surgery for the condition. Epidemiology
Depending on how it is defined, less than 1% to 40% of people have sciatica at some point in time. Sciatica is most common between the ages of 40 and 59, and men are more frequently affected than women. References
External links

"Sciatica". MedlinePlus. U.S. National Library of Medicine.
Targeted treatments, such as immunotherapy, hormonal therapy and kinase inhibitors, are being evaluated for tumors that do not respond to chemotherapy. Prognosis
The 1997 International Germ Cell Consensus Classification is a tool for estimating the risk of relapse after treatment of malignant germ-cell tumor. A small study of ovarian tumors in girls reports a correlation between cystic and benign tumors, and conversely, solid and malignant tumors. Because the cystic extent of a tumor can be estimated by ultrasound, MRI, or CT scan before surgery, this permits selection of the most appropriate surgical plan to minimize risk of spillage of a malignant tumor.Access to appropriate treatment has a large effect on outcome. A 1993 study of outcomes in Scotland found that for 454 men with nonseminomatous (nongerminomatous) GCTs diagnosed between 1975 and 1989, five-year survival increased over time and with earlier diagnosis. Adjusting for these and other factors, survival was 60% higher for men treated in a cancer unit that treated the majority of these men,  though the unit treated more men with the worst prognosis.Choriocarcinoma of the testicles has the worst prognosis of all germ-cell cancers. See also
Embryonic stem cells
Cancer research

References
External links

humpath #2658 (Pathology images)
Childhood Extracranial Germ Cell Tumors
Extragonadal Germ Cell Tumors
Ovarian Germ Cell Tumors
Packer RJ, Cohen BH, Cooney K, Coney K (2000). "Intracranial germ cell tumors". The Oncologist. 5 (4): 312–320. doi:10.1634/theoncologist.2000-0312. PMID 10964999. Cancer.Net: Germ Cell Tumor