Treatment
If the diagnosis is made during stage 1 it may be possible to treat the disease with oral isoprinosine (Inosiplex) and intraventricular interferon alfa, but the response to these drugs varies from patient to patient, and the only accepted treatments are supportive measures such as anticonvulsants. Following onset of stage 2, the disease is invariably fatal. Prognosis
In the classic presentation of the disease death occurs in 1 to 3 years, but faster and slower progressions can occur. Faster deterioration in cases of acute fulminant SSPE leads to death within 3 months of diagnosis. Although the prognosis is bleak for SSPE past stage 1, there is a 5% spontaneous remission rate—this may be either a full remission that may last many years or an improvement in condition giving a longer progression period or at least a longer period with the less severe symptoms. Epidemiology
SSPE is a rare condition, although there is still relatively high incidence in Asia and the Middle East. However, the number of reported cases is declining since the introduction of the measles vaccine—eradication of the measles virus prevents the SSPE mutation and therefore the progression of the disease or even the initial infection itself. References
Further reading
Bonthius D, Stanek N, Grose C (2000). "Subacute sclerosing panencephalitis, a measles complication, in an internationally adopted child". Emerg Infect Dis. 6 (4): 377–81. doi:10.3201/eid0604.000409. PMC 2640885. PMID 10905971. External links
23-273l. at Merck Manual of Diagnosis and Therapy Home Edition
subacute_panencephalitis at NINDS
PubMed Health: Subacute sclerosing panencephalitis Archived 2014-08-08 at the Wayback Machine
synd/1889 at Who Named It?
Epidemiology
BII phobia is one of the more common types of phobia — it is estimated to affect about 3-4% of the general population.Onset of the phobia generally occurs in middle childhood, before the age of ten. There are more reports of incidence of the phobia in younger individuals and those with low education levels. Some studies suggest that women also experience the phobia more frequently, however results are mixed concerning relative prevalences of the phobia between the sexes. == References ==