Tooth pathology is any condition of the teeth that can be congenital or acquired. Sometimes a congenital tooth diseases are called tooth abnormalities. These are among the most common diseases in humans The prevention, diagnosis, treatment and rehabilitation of these diseases are the base to the dentistry profession, in which are dentists and dental hygienists, and its sub-specialties, such as oral medicine, oral and maxillofacial surgery, and endodontics. Tooth pathology is usually separated from other types of dental issues, including enamel hypoplasia and tooth wear. Examples
Congenital
Anodontia

Acquired
Dental caries—Dental caries are known as cavities or tooth decay Bacteria in the mouth use foods that contain sugar or starch to produce acids which eat away at the tooth’s structure causing destruction to the enamel of the teeth. Meanwhile, the minerals in saliva (calcium and phosphate) together with fluoride are repairing the enamel. Dental caries is a chronic disease that can be prevented and show strongly in 6- to 11-year-old children and 12- to 19-year-old adolescents. 9 out of 10 adults are affected with some type of tooth decay. Prevention includes good oral hygiene that consists of brushing twice daily, flossing, eating nutritious meals and limiting snacking, and visiting the dentist on a regular basis. Fluoride treatments benefit the teeth by strengthening while sealants help chewing surfaces to not decay. Severe cases can lead to tooth extraction and dentures.
Hawkinsinuria is an autosomal dominant metabolic disorder affecting the metabolism of tyrosine.Normally, the breakdown of the amino acid tyrosine involves the conversion of 4-hydroxyphenylpyruvate to homogentisate by 4-hydroxyphenylpyruvate dioxygenase. Complete deficiency of this enzyme would lead to tyrosinemia III. In rare cases, however, the enzyme is still able to produce the reactive intermediate 1,2-epoxyphenyl acetic acid, but is unable to convert this intermediate to homogentisate. The intermediate then spontaneously reacts with glutathione to form 2-L-cystein-S-yl-1,4-dihydroxy-cyclohex-5-en-1-yl acetic acid (hawkinsin).Patients present with metabolic acidosis during the first year of life, and growth arrest around the time of weaning off breast milk. Treatment involves a diet containing a low amount of phenylalanine and tyrosine. Tolerance toward these amino acids normalizes as the patients get older. Then only a chlorine-like smell of the urine indicates the presence of the condition. Patients have a normal life and do not require treatment or a special diet.The production of hawkinsin is the result of a gain-of-function mutation. Inheritance of hawkinsinuria is therefore autosomal dominant (presence of a single mutated copy of the gene causes the condition). The gene affected is the HPD gene encoding 4-hydroxyphenylpyruvic acid dioxygenase, on chromosome 12q24. It is unusual in that most other inborn errors of metabolism are caused by loss-of-function mutations, and hence have recessive inheritance (condition occurs only if both copies are mutated). See also
4-Hydroxyphenylpyruvate dioxygenase

References


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