There may be certain parts of the muscles or tendons (connective tissue connecting the muscles to bones) that are especially painful when pressed
Trigeminal neuralgia: attacks of shooting pain down the face that may be triggered by touching the face or temperature changes
Dental pain from cavities or an abscess
Oral cavity carcinomaConditions causing irritation of the facial nerve (cranial nerve VII) or glossopharyngeal nerve (cranial nerve IX):
Tonsillitis: infection/inflammation of the tonsils
Post-tonsillectomy: pain following surgical removal of the tonsils
Pharyngitis: infection/inflammation of the throat
Sinusitis
Parotitis: inflammation of the parotid gland, the salivary gland right in front of the ear
Carcinoma of the oropharynx (base of tongue, soft palate, pharyngeal wall, tonsils)Conditions causing irritation of the vagus nerve (cranial nerve X):
GERD
Myocardial ischemia (inadequate oxygen supply to the heart muscle)Conditions causing irritation of cervical nerves C2-C3:
Cervical spine trauma, arthritis (joint inflammation), or tumor
Temporal arteritis: an autoimmune disorder leading to inflammation of the temporal artery, a large artery in the head. This condition tends to occur in adults older than 50. Pathophysiology
Primary ear pain
The ear can be anatomically divided into the external ear, the external auditory canal, the middle ear, and the inner ear. These three are indistinguishable in terms of the pain experienced. Secondary ear pain
Many different nerves provide sensation to the various parts of the ear, including cranial nerves V (trigeminal), VII (facial), IX (glossopharyngeal), and X (vagus), and the great auricular nerve (cervical nerves C2-C3). These nerves also supply other parts of the body, from the mouth to the chest and abdomen.
A downward dose adjustment may be necessary with this particular instance of polypharmacy.Severe hypotension was reported with Fentanyl anesthesia when it was combined with other Calcium Channel Blockers. Even though Isradipine, another Calcium Channel Blocker, has not been used in conjunction with Fentanyl anesthesia in any studies, caution is advised.Note: There was no significant interaction between Isradipine and Warfarin (Coumadin), Isradipine and Microzide Hydrochlorothiazide, Isradipine and Lanoxin (Digoxin), and Isradipine and Nitrostat (Nitroglycerin). Overdose
Symptoms of an Isradipine overdose include:
Lethargy
Sinus tachycardia
Transient hypotension

Stereochemistry
Isradipine contains a stereocenter and consists of two enantiomers, more precisely atropisomers. This is a racemate, i.e. a 1: 1 mixture of ( R ) - and the ( S ) - Form:

References
Further reading
External links
MedlinePlus DrugInfo medmaster-a693048
Diseases Database (DDB): 30003
Drug offers hope for Parkinsons - BBC News, 11 June 2007. [1] - Commentary of Chan et al. publication
[2] - ArsTechnica - Why neurons die in Parkinsons patients