Prophet Jeremiah portrays a Queen mother as sharing in her sons rule over the kingdom in Jeremiah 13:18-20. The wife of Prophet Isaiah was a Prophetess. Isaiah 8:3

Expectation of fidelity and violence related to adultery
There is a widely held expectation, which has existed for most of recorded history and in most cultures, that a wife is not to have sexual relations with anyone other than her legal husband. A breach of this expectation of fidelity is commonly referred to as adultery or extramarital sex. Historically, adultery has been considered to be a serious offense, sometimes a crime, and a sin. Even if that is not so, it may still have legal consequences, particularly as a ground for a divorce. Adultery may be a factor to consider in a property settlement, it may affect the status of children, the custody of children; moreover, adultery can result in social ostracism in some parts of the world. In addition, affinity rules of Catholicism, of Judaism and of Islam prohibit an ex-wife or widow from engaging in sexual relations with and from marrying a number of relatives of the former husband. In parts of the world, adultery may result in violent acts, such as honor killings or stoning. Some jurisdictions, especially those that apply Sharia law, allow for such acts to take place legally.As of September 2010, stoning is a legal punishment in countries such as Saudi Arabia, Sudan, Iran, Yemen, the United Arab Emirates, and some states in Nigeria as punishment for zina al-mohsena ("adultery of married persons").
The signs and symptoms of 3-methylglutaconic aciduria type IV are variable and overlap with types I-III. The incidence of 3-methylglutaconic aciduria type IV is unknown. Treatment
There is no known treatment or cure. Epidemiology
3-Methylglutaconic aciduria seems to be  most prevalent amongst the Jewish population of Iraq. However, a high concentration of one type is found in the Saguenay-Lac-Saint-Jean region of Canada. This suggests that the disease is more frequent in insular areas where there is more likelihood that both parents are carriers, a higher birth rate, and a greater frequency of consanguineous marriages. As all types of 3-Methylglutaconic aciduria are known to be genetic diseases and show a recessive inheritance pattern, consanguineous marriages (in which both partners may have inherited the mutation from the same ancestor) increase the chances of having a baby with the condition. References
External links
"3-METHYLGLUTACONIC ACIDURIA". Datagenno. Anikster Y (2020). Adam MP, Ardinger HH, Pagon RA,  et al. (eds.). "Costeff Syndrome". GeneReviews® [Internet]. University of Washington. PMID 20301646. NBK1473. 3-Methylglutaconic aciduria at NLM Genetics Home Reference