In other cases it is inherited from one affected parent.Loeys–Dietz syndrome was identified and characterized by pediatric geneticists Bart Loeys and Harry "Hal" Dietz at Johns Hopkins University in 2005. Signs and symptoms
There is considerable variability in the phenotype of Loeys–Dietz syndrome, from mild features to severe systemic abnormalities. The primary manifestations of Loeys–Dietz syndrome are arterial tortuosity (winding course of blood vessels), widely spaced eyes (hypertelorism), wide or split uvula, and aneurysms at the aortic root. Other features may include cleft palate and a blue/gray appearance of the white of the eyes. Cardiac defects and club foot may be noted at birth.There is overlap in the manifestations of Loeys–Dietz and Marfan syndromes, including increased risk of ascending aortic aneurysm and aortic dissection, abnormally long limbs and fingers, and dural ectasia (a gradual stretching and weakening of the dura mater that can cause abdominal and leg pain).
Lichen ruber moniliformis is a rare skin disease named for Fred Wise and Charles R. Rein.It is one of several diseases also known as Kaposis disease, based on its characterization in 1886 by Moritz Kaposi.It is thought to be a rare variety of lichen planus.It is also known as "Morbus moniliformis lichenoides". Presentation
The disease causes numerous whitish punctiform papules and brownish macules arranged in a necklace-like pattern. Diagnosis
Treatment
See also
Lichen planus
List of cutaneous conditions

References


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