In the lower doses used for water fluoridation, the only clear adverse effect is dental fluorosis, which can alter the appearance of childrens teeth during tooth development; this is mostly mild and is unlikely to represent any real effect on aesthetic appearance or on public health. A chronic fluoride ingestion of 1 ppm of fluoride in drinking water can cause mottling of the teeth (fluorosis) and an exposure of 1.7 ppm will produce mottling in 30%–50% of patients. Chemical structure
Sodium fluoride is an inorganic ionic compound, dissolving in water to give separated Na+ and F− ions. Like sodium chloride, it crystallizes in a cubic motif where both Na+ and F− occupy octahedral coordination sites; its lattice spacing, approximately 462 pm, is somewhat smaller than that of sodium chloride. Occurrence
The mineral form of NaF, villiaumite, is moderately rare. It is known from plutonic nepheline syenite rocks. Production
NaF is prepared by neutralizing hydrofluoric acid or hexafluorosilicic acid (H2SiF6), both byproducts of the reaction of fluorapatite (Ca5(PO4)3F) from phosphate rock during the production of superphosphate fertilizer. Neutralizing agents include sodium hydroxide and sodium carbonate. Alcohols are sometimes used to precipitate the NaF:

HF  +  NaOH  →   NaF  +  H2OFrom solutions containing HF, sodium fluoride precipitates as the bifluoride salt sodium bifluoride (NaHF2). Heating the latter releases HF and gives NaF. HF  +  NaF  ⇌   NaHF2In a 1986 report, the annual worldwide consumption of NaF was estimated to be several million tonnes. See also
Cryolite
Fluoride therapy

References
External links
"Sodium fluoride".
Technetium-99 or MR scans are not required for diagnosis, but might be useful for prognostic purposes. Prevention
The Wilderness Medical Society recommends covering the skin and scalp, taking in adequate nutrition, avoiding constrictive footwear and clothing, and remaining active without causing exhaustion. Supplemental oxygen might also be of use at high elevations. Repeated exposure to cold water makes people more susceptible to frostbite. Additional measures to prevent frostbite include:
Avoiding temperatures below −23 °C (-9 °F)
Avoiding moisture, including in the form of sweat and/or skin emollients
Avoiding alcohol and drugs that impair circulation or natural protective responses
Layering clothing
Using chemical or electric warming devices
Recognizing early signs of frostnip and frostbite

Treatment
Individuals with frostbite or potential frostbite should go to a protected environment and get warm fluids. If there is no risk of re-freezing, the extremity can be exposed and warmed in the groin or underarm of a companion. If the area is allowed to refreeze, there can be worse tissue damage. If the area cannot be reliably kept warm, the person should be brought to a medical facility without rewarming the area. Rubbing the affected area can also increase tissue damage. Aspirin and ibuprofen can be given in the field to prevent clotting and inflammation. Ibuprofen is often preferred to aspirin because aspirin may block a subset of prostaglandins that are important in injury repair.The first priority in people with frostbite should be to assess for hypothermia and other life-threatening complications of cold exposure. Before treating frostbite, the core temperature should be raised above 35 °C.