Lipomatosis is believed to be an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders. In 1993, a genetic polymorphism within lipomas was localized to chromosome 12q15, where the HMGIC gene encodes the high-mobility-group protein isoform I-C. This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 have also been observed within.Although this condition is benign, it can sometimes be very painful depending on location of the lipomas. Some patients who are concerned with cosmetics seek removal of individual lipomas. Removal can include simple excision, endoscopic removal, or liposuction.Other entities which are accompanied by multiple lipomas include Proteus syndrome, Cowden syndrome and related disorders due to PTEN gene mutations, benign symmetric lipomatosis (Madelung disease), Dercums Disease, familial lipodystrophy, hibernomas, epidural steroid injections with epidural lipomatosis, and familial angiolipomatosis. See also
Pelvic lipomatosis    — A rare disease  most often seen in older obese black men with hypertension. Virchows metamorphosis — lipomatosis in the heart and salivary glands. Dercums — A rare condition characterized by generalized obesity and painful fatty tumors in the adipose tissue. References


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Melanoderma is a genus of two species of white rot poroid fungi in the family Polyporaceae. The genus was circumscribed in 2011 to accommodate the type species Melanoderma microcarpum, found in China. Melanoderma disciforme, found in Yunnan, was added to the genus in 2015. The generic name Melanoderma refers to the dark-coloured crust of the cap. Phylogenetic analyses shows that Melanoderma is closely related to the genus Vanderbylia. == References ==