It is thought that bimatoprost mimics the human bodys own prostamides (which are chemically similar), a class of substances related to prostaglandins, but with an unknown mechanism of action. No prostamide receptor has been identified as of 2015; the search is ongoing. As of 2019 it was thought that bimatoprost worked via the trabecular meshwork and uveoscleral pathways. Pharmacokinetics
Bimatoprost is well absorbed through the cornea. It starts lowering intraocular pressure after four hours, lasting for at least 24 hours. A low percentage enters the bloodstream. In the blood plasma, peak concentrations are reached after 10 minutes, then drop below the detection limit of 25 pg/ml after 1.5 hours. The substance does not accumulate in the body.Plasma protein binding is 88%. Bimatoprost is metabolized by oxidation, N-deethylation and glucuronidation, forming a variety of metabolites. Biological half-life was measured to be 45 minutes after intravenous infusion. 67% are eliminated via the kidney, and 25% via the feces. References
Further reading
"Prostaglandin Analogues for Ophthalmic Use: A Review of the Comparative Clinical Effectiveness and Cost-Effectiveness". CADTH Rapid Response Reports. July 2015. PMID 26985536. External links
"Bimatoprost". Drug Information Portal. U.S. National Library of Medicine.
Some of the characteristics of a dental open bite include:
Normal lower anterior facial height
Horizontal/Hypodivergent growth pattern
Occlusal plane diverges after the premolar contact
Under-eruption of the anterior incisors
Over-eruption of the posterior molars
Proclined upper and lower incisors
No vertical maxillary excess or gummy smile
Presence of habits such as thumb sucking, tongue thrusting
Spacing between anterior incisors due to their proclination

Open bite correction
Primary/mixed dentition
Behavior modification
Behavior therapy is important especially when children are in their primary dentition in the pre-adolescent age. Improving habits at this time may lead to self-correction of open bite in many cases. Sometimes presence of infantile swallowing into early childhood may lead to an anterior open bite. Habit control through appliances such as Tongue crib or Tongue spurs may be used in adolescents if behavior modification fails to stop the habit. Tongue crib therapy
A tongue crib is a removable appliance placed in the maxillary arch to stop the tongue thrusting habit. This appliance may be used in patients with mixed dentition or permanent dentition. The tongue crib is attached through a bar to two bands placed on the upper 1st molars. The crib is shaped like a horseshoe with metal bars that prevent thrusting. The tongue crib eliminates the habit in approximately 90% of patients. . Huang et al. published a study in 1990 which stated that patients who achieved a positive overbite during their tongue crib therapy had a good chance of maintaining that overbite after their orthodontic treatment.