Many different treatments have been attempted, with limited success in certain patients:  purine analogues (pentostatin, fludarabine, cladribine), chlorambucil, and various forms of combination chemotherapy regimens, including cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP), etoposide, bleomycin (VAPEC-B). Alemtuzumab (Campath), an anti-CD52 monoclonal antibody that attacks white blood cells, has been used in treatment with greater success than previous options. In one study of previously treated people with T-PLL, people who had a complete response to alemtuzumab survived a median of 16 months after treatment.Some patients who successfully respond to treatment also undergo stem cell transplantation to consolidate the response. Prognosis
T-PLL is an extremely rare aggressive disease, and patients are not expected to live normal lifespans. Before the recent introduction of better treatments, such as alemtuzumab, the median survival time was 7.5 months after diagnosis. More recently, some patients have survived five years and more, although the median survival is still low. Epidemiology
About four men are diagnosed with this disease for every three women. Despite its overall rarity, it is also the most common type of mature T cell leukemia. References


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The anatomy of the domestic cat is similar to that of other members of the genus Felis. Mouth
Permanent dentition teeth
Cats are carnivores that have highly specialized teeth. There are four types of permanent dentition teeth that structure the mouth: twelve incisors, four canines, ten premolars and four molars. The premolar and first molar are located on each side of the mouth that together are called the carnassial pair. The carnassial pair specialize in cutting food and are parallel to the jaw. The incisors located in the front section of the lower and upper mouth are small, narrow, and have a single root. They are used for grasping and biting food. Deciduous dentition teeth
A cat also has a deciduous dentition prior to the formation of the permanent one. This dentition emerges seven days after birth and it is composed of 26 teeth with slight differences. The mouth will have smaller incisors, slender and strongly curved upper canines, vertical lower canines, and even smaller upper and lower molars. Although the upper and lower molars are smaller than the ones that arise during permanent dentition, the similarities are striking. Tongue
The cats tongue is covered in a mucous membrane and the dorsal aspect has 5 types of sharp spines, or papillae. The 5 papillae are filiform, fungiform, foliate, vallate, and conical. A cats sense of smell and taste work closely together, having a vomeronasal organ that allows them to use their tongue as scent tasters, while its longitudinal, transverse, and vertical intrinsic muscles aid in movement.