Alacrima refers to an abnormality in tear production that could mean reduced tear production or absent tear production. Because a lack of tears presents in only in a few rare disorders, it aids in diagnosis of these disorders, including Triple-A syndrome and NGLY1 deficiency.Alacrima can be formally diagnosed through a Schirmers test. References


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Infections of domestic dogs have been particularly common in Chad, where they helped reignite dracunculiasis transmission in 2010. Dogs are thought to be infected by eating a paratenic host, likely a fish or amphibian. As with humans, prevention efforts have focused on preventing infection by encouraging people in affected areas to bury fish entrails as well as to identify and tie up dogs with emerging worms so that they cannot access drinking water sources until after the worms have emerged. Domestic ferrets can be infected with D. medinensis in laboratory settings, and have been used as an animal disease model for human dracunculiasis.Different Dracunculus species can infect snakes, turtles, and other mammals. Animal infections are most widespread in snakes, with nine different species of Dracunculus described in snakes in the United States, Brazil, India, Vietnam, Australia, Papua New Guinea, Benin, Madagascar, and Italy. The only other reptile affected is the snapping turtle with infected common snapping turtles described in several U.S. states, and a single infected South American snapping turtle described in Costa Rica. Infections of other mammals are limited to the Americas. Raccoons in the U.S. and Canada are most widely impacted, particularly by D. insignis; however, Dracunculus worms have also been reported in American skunks, coyotes, foxes, opossums, domestic dogs, domestic cats, and (rarely) muskrats and beavers. Notes
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"Guinea Worm Disease Eradication Program". Carter Center.