The musical group Evelyn, Evelyn depicts a pair of conjoined twin sisters—often referred to as "The Evelyn Sisters"—in many of their songs and music videos. The fictional sisters are shown to be child prostitutes in the music video for "Sandy Fishnets", and the song "Evelyn, Evelyn" describes their longing for privacy and to be separated from one another. The Bride with White Hair, a 1993 Hong Kong movie, features conjoined twin villains. The animated series Duckman featured Eric T. Duckmans sons Charles (voiced by Dana Hill in 1994–1996, Pat Musick in 1997) and Mambo (voiced by E. G. Daily) who are dicephalic parapagus twins where their heads share a body. Fran Bow, a 2015 indie psychological horror game, includes Clara and Mia Buhalmet, a set of mentally ill conjoined twins, as characters. They were surgically sewn together, much like an experiment performed by Josef Mengele, also known as the Angel of Death, in which a pair of twins were sewn together back to back by blood vessels and organs, in an attempt to create conjoined twins. The Peach Tree, a Korean novel and film, portrays conjoined twin brothers falling in love with the same woman. The 1999 movie Twin Falls Idaho portrays conjoined twin brothers who are played by two non-conjoined identical twin brothers, one of whom directed the film, and both of whom co-wrote the screenplay.
They were separated on June 5, 2020, at the Bambino Gesù Pediatric Hospital in Rome, Italy. Mercy and Goodness Ede, born August 13, 2019, conjoined by the chest and abdomen. Successfully separated at the National Hospital in Abuja, Nigeria in November 2019. Marie-Cléa and Marie-Cléanne Papillon, born in Mauritius in 2019. Conjoined from neck to abdomen, but also from heart which had seven rooms, instead of four. Marie-Cléa did not survive the surgery to separate the two. Susannah and Elizabeth Castle, born April 22, 2021, and separated December 10, 2021 in Philadelphia, Pennsylvania. In fiction
Conjoined twins have been the focus of several noteworthy works of entertainment, including:

Stuck on You (2003 film), a 2003 American comedy film screen written and directed by the Farrelly brothers and starring Matt Damon and Greg Kinnear as conjoined twin brothers, whose conflicting aspirations provide both conflict and humorous situations, in particular when one of them wishes to move to Hollywood to pursue a career as an actor. Alone, a Thai horror film following Pim after the death of her sister Ploy and their subsequent separation. Blood Sisters focuses on a French Canadian model who has a separated conjoined twin. Irish author Sarah Crossan won the Carnegie Medal for her verse novel, One. The story follows the life and survival of conjoined twin sisters. The book also won The Booksellers 2016 prize for young adult fiction and the Irish Childrens Book of the Year.