He "concluded that satisfaction from penile penetration [is] mainly psychological or perhaps the result of referred sensation".Masters and Johnsons research into the female sexual response cycle, as well as Shere Hites, generally supported Kinseys findings about female orgasm. Masters and Johnsons research on the topic came at the time of the second-wave feminist movement, and inspired feminists such as Anne Koedt, author of The Myth of the Vaginal Orgasm, to speak about the "false distinction" made between clitoral and vaginal orgasms and womens biology not being properly analyzed. Clitoral and vaginal relationships
Accounts that the vagina is capable of producing orgasms continue to be subject to debate because, in addition to the vaginas low concentration of nerve endings, reports of the G-spots location are inconsistent—it appears to be nonexistent in some women and may be an extension of another structure, such as the Skenes gland or the clitoris, which is a part of the Skenes gland. In a January 2012 The Journal of Sexual Medicine review examining years of research into the existence of the G-spot, scholars stated that "[r]eports in the public media would lead one to believe the G-spot is a well-characterized entity capable of providing extreme sexual stimulation, yet this is far from the truth".Possible explanations for the G-spot were examined by Masters and Johnson, who were the first researchers to determine that the clitoral structures surround and extend along and within the labia.
Key clinical signs as well as gross and microscopic features that are most useful for differentiating Mareks disease from lymphoid leukosis and reticuloendotheliosis include:

Age: Mareks disease can affect birds at any age, including <16 weeks of age;
Clinical signs: Frequent wing and leg paralysis;
Incidence: >5% in unvaccinated flocks;
Potential nerve enlargement;
Interfollicular tumors in the bursa of Fabricius;
CNS involvement;
Lymphoid proliferation in skin and feather follicles;
Pleomorphic lymphoid cells in nerves and tumors; and
T-cell lymphomas.In addition to gross pathology and histology, other advanced procedures used for a definitive diagnosis of Mareks disease include immunohistochemistry to identify cell type and virus-specific antigens, standard and quantitative PCR for identification of the virus, virus isolation to confirm infections, and serology to confirm/exclude infections. The World Organisation for Animal Health (OIE) reference laboratory for Mareks disease is Avian Viral Oncogenesis group (led by Professor Venugopal Nair OBE) at The Pirbright Institute, UK.PCR blood testing can also detect Mareks disease, and proper testing can differentiate between a vaccinated bird with antibodies and a true positive for Mareks disease. Mareks disease is not treatable, however, supportive care can help. It is recommended that all flocks positive for Mareks disease remain closed, with no bird being introduced or leaving the flock. Strict biosecurity and proper cleaning is essential, using products like Activated Oxine or Virkon S and reducing dander buildup in the environment. Proper diet, regular deworming and vitamin supplements can also help keep infected flocks healthier. Reducing stress is also a key component, as stress will often bring about illness in birds infected with Mareks disease.