Timolol is a non-selective beta-adrenergic antagonist. Comparison to other products
Despite each of the active ingredients being availed in their own respective formulations, combination formulations are typically more convenient for the patient without sacrificing any quality in therapy. In the case of Cosopt, the combination formulation dosed twice daily provides equivalent treatment to both dorzolamide 2% dosed two times daily and timolol 0.5% dosed three times daily. Specifically, the mean reduction in intraocular pressure was 27.4% for the combination product, 15.5% for dorzolamide 2%, and 22.2% for timolol 0.5%. Compared to other products such as latanoprost, both are equally efficacious with regard to lowering intraocular pressure and getting patients to reach their target intraocular pressure. Cosopt, though, is typically less well tolerated than other treatments due to a well documented feeling of ocular burning upon administration. History
Cosopt gained Food and Drug Administration (FDA) approval in April 1998 and was supplied initially by Merck. In 2016, Merck & Co. had $95.3 billion in total assets, $40.3 billion in total equity, $24.3 billion in long term debt, and $13.4 billion in working capital. This same year Merck & Co spent $20 billion total split virtually evenly between research and development (R&D) and marketing efforts. Cosopt had annual sales of $342 million during the 12 months before June 2008.
Cost
The brand name Cosopt currently costs upwards of $200 after discounts while the generic formulation costs around $70 cash. The more recent preservative free formulation can be purchased for less than the original brand name formulation at around $160

References
External links
Drug information from the NIH