Indometacin readily crosses the placenta and can reduce fetal urine production to treat polyhydramnios. It does so by reducing renal blood flow and increasing renal vascular resistance, possibly by enhancing the effects of vasopressin on the fetal kidneys. Other modes of action for indometacin are:

it inhibits motility of polymorphonuclear leukocytes, similar to colchicine
it uncouples oxidative phosphorylation in cartilaginous (and hepatic) mitochondria, like salicylates
it has been found to specifically inhibit MRP (multidrug resistance proteins) in murine and human cells

Nomenclature
Indometacin is the INN, BAN, and JAN of the drug while indomethacin is the USAN, and former AAN and BAN. See also
Indometacin farnesil
Indometacin morpholinylamide
Pravadoline
GW-405,833

References
External links
Effects of Perinatal Indomethacin Treatment on Preterm Infants, academic dissertation (PDF)
Indomethacin, from MedicineNet
Indomethacin, from Drugs.com
Indocin: Description, chemistry, ingredients, from RxList.com
If carpal tunnel syndrome develops, a further decrease in hand function can occur. The bones themselves may be affected, resulting in short stature. In addition, pebbly, ivory-colored skin lesions may be found on the upper arms, legs, and upper back of some people with it. These skin lesions are considered pathognomic for the disease. Finally, the storage of GAGs in the brain can lead to delayed development with subsequent intellectual disability and progressive loss of function.The age at onset of symptoms and the presence or absence of behavioral disturbances are predictive factors of ultimate disease severity in very young patients. Behavioral disturbances can often mimic combinations of symptoms of attention deficit hyperactivity disorder, autism, obsessive compulsive disorder, and/or sensory processing disorder, although the existence and level of symptoms differ in each affected child. They often also include a lack of an appropriate sense of danger, and aggression. The behavioral symptoms of MPS II generally precede neurodegeneration and often increase in severity until the mental handicaps become more pronounced. By the time of death, most children with severe MPS II have severe mental disabilities and are completely dependent on their caretakers. Genetics
Since Hunter syndrome is an X-linked recessive disorder, it preferentially affects male patients. The IDS gene is located on the X chromosome. The IDS gene encodes for an enzyme called iduronate-2-sulfatase (I2S). A lack of this enzyme leads to a buildup of GAGs, which cause the symptoms of MPS II.