However, in more severe cases, non-steroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen may be used. Surgery is very rarely performed. In cases where symptoms do not resolve in a reasonable amount of time and NSAID therapy is ineffective, the provider may choose to surgically resect the area where the pain is localized. Additionally, the stumps of the vas deferens can be burned and closed off in order to reduce the pain the patient is experiencing and prevent it from happening again.When sperm granulomas are occasionally mistaken for other conditions, such as testicular tumors, a more complicated treatment approach such as an orchiectomy may be accidentally used.Cauterization is a vasectomy method used to seal the vas deferens by utilizing heat or electricity to burn the lumen. Using thermal (heat) cautery instead of electrocautery can help prevent granulomas and nodular thickening.Refraining from ejaculation for 1 week can potentially reduce the risk of developing a sperm granuloma.There is also evidence that sperm granuloma formation may be linked to testosterone deficiency. Testosterone supplementation may reduce the inflammation related to sperm granulomas and potentially even prevent them from occurring. However, this evidence is only supported in animal models. Complications
There have been complications involving sperm granuloma. A pediatric case documented a 13 year old boy who was admitted to the hospital with edema and redness on his left hemiscrotum. Upon a physical examination, they found the scrotum to be enlarged, soft, red and painless. Initial sonographs detected possiblility of inflammation of the testis and epididymis.
Pegaspargase, sold under the brand name Oncaspar, is a medication used in the treatment of acute lymphoblastic leukemia (ALL). Often it is used together with anthracycline, vincristine, and corticosteroids (for example prednisone and dexamethasone). Pegaspargase can be administered either via an intravenous infusion or a intramuscular injection.Known side effects include allergic reactions, coagulopathy, high blood sugar, affected liver function, pancreas inflammation, and blood clots in the brain. There is no data regarding the usage of pegaspargase during pregnancy. Therefor caution should be observed and pegaspargase should only be used during pregnancy when the benefits outweigh the possible risks. Pegaspargase is a modified version of the enzyme asparaginase which has undergone PEGylation. It works by breaking down the amino acid asparagine that are circulating in the bloodstream. The circulating asparagine is essential for the cancer cells to enable growth since they cant produce their own, in contrast to normal cells. The normal cells are therefor less affected by pegaspargase. Pegaspargase was approved for medical use in the United States in 1994. It is on the World Health Organizations List of Essential Medicines. It is made by Sigma-Tau. References
External links
"Pegaspargase". Drug Information Portal. U.S. National Library of Medicine.