The highest vitamin contents can be found in the leaves. Poultry: Egg yolk colouring in laying hens
In laying hens, nettle can be used as an egg yolk colorant instead of artificial pigments or other natural pigments (derived from marigold for yellow). Nettle has high carotenoid contents, especially lutein, β-carotene and zeaxanthin, of which lutein and zeaxanthin act as yellow pigments. Feeding as little as 6.25 g dry nettle per kg feed is as effective as the synthetic pigments to colour the egg yolk. Feeding nettle has no detrimental effect on the performance of the laying hens or on the general quality of eggs. Ruminants
Ruminants avoid fresh stinging nettles; however, if the nettles are wilted or dry, voluntary intake can be high. Use in agriculture / horticulture
In the European Union and United Kingdom, nettle extract can be used as a insecticide, fungicide, and acaricide under Basic Substance regulations. As an insecticide nettle extract can be used for the control of codling moth, diamondback moth, and spider mites. As a fungicide, it can be used for the control of Pythium root rot, powdery mildew, early blight, late blight, Septoria blight, Alternaria leaf spot, and grey mould. Gardening
Nettles have a number of other uses in the vegetable garden, including the potential for encouraging beneficial insects.
Lymph node: Enlargement of the liver in 20%, spleen in 30% and lymph nodes in 50% of Histiocytosis cases. Endocrine glands: Hypothalamic pituitary axis  commonly involved. Diabetes insipidus is most common. Anterior pituitary hormone deficiency is usually permanent. Lungs: some patients are asymptomatic, diagnosed incidentally because of lung nodules on radiographs; others experience chronic cough and shortness of breath. Less frequently gastrointestinal tract, central nervous system, and oral cavity. Pathophysiology
The pathogenesis of Langerhans cell histiocytosis (LCH) is a matter of debate. There are ongoing investigations to determine whether LCH is a reactive (non-cancerous) or neoplastic (cancerous) process. Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive secretion of multiple cytokines by dendritic cells and bystander-cells (a phenomenon known as cytokine storm) in the lesional tissue, favorable prognosis and relatively good survival rate in patients without organ dysfunction or risk organ involvement.On the other hand, the infiltration of organs by monoclonal population of pathologic cells, and the successful treatment of subset of disseminated disease using chemotherapeutic regimens are all consistent with a neoplastic process. In addition, a demonstration, using X chromosome–linked DNA probes, of LCH as a monoclonal proliferation provided additional support for the neoplastic origin of this disease. While clonality is an important attribute of cancer, its presence does not prove that a proliferative process is neoplastic.