IgG tTGA antibodies should be checked in selective IgA deficiency, which can be associated with celiac disease and occurs in as many as one in 40 celiac patients.Nevertheless, the absence of serological markers does not certainly exclude celiac disease. In those with celiac disease before diagnosis (on a gluten-containing diet), celiac disease serological markers are not always present. As the age of diagnosis increases, these antibody titers decrease, and may be low or even negative in older children and adults. The absence of celiac disease-specific antibodies is more common in patients without villous atrophy who only have duodenal lymphocytosis (Marsh 1 lesions) and who respond to a gluten-free diet with histological and symptomatic improvement. Duodenal biopsies
According to the diagnostic criteria established by the consensus conferences (2011 and 2013), it is necessary to perform duodenal biopsies to exclude celiac disease in symptomatic people with negative specific celiac disease antibodies. Because of the patchiness of the celiac disease lesions, four or more biopsies are taken from the second and third parts of the duodenum, and at least one from the duodenal bulb. Even in the same biopsy fragments, different degrees of pathology may exist.Duodenal biopsies in people with NCGS are always almost normal – an essential parameter for diagnosis of NCGS, although is generally accepted that a subgroup of people with NGCS may have an increased number of duodenal intraepithelial lymphocytes (IELs) ( ≥25/100 enterocytes), which represent Marsh I lesions.
In 2014, Frank and Louie died at the age of fifteen. See also
Conjoined twins
Craniopagus parasiticus
Cyclopia
Durga, a three-eyed Hindu goddess
Edward Mordake, a disputed story of a 19th-century man with a face on the back of his head
Futakuchi-onna, a female Japanese yōkai with mouth on back of her head/hair
Janus, a Roman god with two faces
Kara Mia, a Philippine TV series that tells the story of a young woman with two faces divided in one body. Polycephaly

References
External links

Armand Marie, Leroi (2005). Mutants: On Genetic Variety and the Human Body. New York, NY: Penguin Books. ISBN 9780142004821. Retrieved March 13, 2014. Howie, Sarah; Fisher, Carolyn Elaine, eds. (2010). Shh and Gli Signalling in Development. Molecular Biology Intelligence Unit. New York, NY: Springer Science+Business Media, Inc. doi:10.1007/978-0-387-39957-7. ISBN 978-0-387-39957-7. Retrieved March 13, 2014. Tapadia MD, Cordero DR, Helms JA (November 2005). "Its all in your head: new insights into craniofacial development and deformation". J. Anat. 207 (5): 461–77. doi:10.1111/j.1469-7580.2005.00484.x. PMC 1571563. PMID 16313388. ‘Sonic Hedgehog’ sounded funny, at first. New York Times, 12 November 2006. Rediscovering biology: Unit 7, Genetics of development. Expert interview transcripts, interview with John Incardona, PhD. explanation of the discovery and naming of the sonic hedgehog gene
Page for sonic hedgehog homolog (SHH) at The Human Genome Organisation (HUGO)
Two-faced kitten has image problem at Channel4000
Two-faced kitten shocks owner, veterinarian at OregonNews.com
Two-faced cat sets record as oldest living "Janus" cat at Reuters
diprosopus kitten
diprosopus piglet
diprosopus calf
Rescue Kitten Was Born With Two Face Who Rejected By Her Cat Mom diprosopus kitten
Baby with 2 faces born in north India MSNBC
Image:Diprosopus