Cryoglobulinemia is a medical condition in which the blood contains large amounts of pathological cold sensitive antibodies called  cryoglobulins – proteins (mostly immunoglobulins themselves) that become insoluble at reduced temperatures. This should be contrasted with cold agglutinins, which cause agglutination of red blood cells. Cryoglobulins typically precipitate (clumps together) at temperatures below normal body temperature – 37 degrees Celsius (99 degrees Fahrenheit) – and will dissolve again if the blood is heated. The precipitated clump can block blood vessels and cause toes and fingers to become gangrenous. While this disease is commonly referred to as cryoglobulinemia in the medical literature, it is better termed cryoglobulinemic disease for two reasons: 1) cryoglobulinemia is also used to indicate the circulation of (usually low levels of) cryoglobulins in the absence of any symptoms or disease and 2) healthy individuals can develop transient asymptomatic cryoglobulinemia following certain infections.In contrast to these benign instances of circulating cryoglobulins, cryoglobulinemic disease involves the signs and symptoms of precipitating cryoglobulins and is commonly associated with various pre-malignant, malignant, infectious, or autoimmune diseases that are the underlying cause for production of the cryoglobulins. Classification
Since the first description of cryoglobulinemia in association with the clinical triad of skin purpura, joint pain, and weakness by Meltzer et al. in 1967, the percentage of cryoglobulinemic diseases described as essential cryoglobulinemia or idiopathic cryoglobulinemia, that is cryoglobulinemic disease that is unassociated with an underlying disorder, has fallen.
In contrast, 93.99% of her sample reported having done spanking or having had it done to them, and  61.96% reported having used or been exposed to feathers/fur. It is impossible to extrapolate Rehors data onto the general population, but her study does give a guide to prevalence in the North American BDSM community. In Channel 4s 2017 nationwide Great British Sex survey, watersports (or urolagnia) was ranked ninth in popularity among sexual fetishes in the UK. Notable cases
Chuck Berry: American musician who was featured urinating on a woman in a sex tape, and was sued for videotaping dozens of women in the restroom of a restaurant he owned. Havelock Ellis: British sexologist who was impotent until at age sixty he discovered that he was aroused by the sight of a woman urinating. Albert Fish: an American serial killer, also known as The Grayman, The Boogeyman. He wrote several letters to widows with want-ads in The New York Times and described in detail women urinating on him, inside of him, and in cups so that he could drink it. He later forced children to drink urine. Ashley MacIsaac: Nova Scotian fiddler and singer. In 1996 he spoke with a Macleans interviewer mentioning his sexual life, including his boyfriend and his taste for urolagnia. In 2003 he told an interviewer for the Montreal Mirror that he loves to have men urinate on him. Ricky Martin: a Puerto Rican singer. He gave an interview with Blender magazine in which he stated that he enjoyed "giving the golden shower".