An individual will be considered a carrier if one mutant copy of the gene is inherited, and will not illustrate any symptoms. The disease affects both men and women equally, and overall, is a very uncommon inherited or acquired disorder. Non-inheritance and other factors
There are two types of prothrombin deficiencies that occur depending on the mutation:Type I (true deficiency), includes a missense or nonsense mutation, essentially decreasing prothrombin production. This is associated with bleeding from birth. Here, plasma levels of prothrombin are typically less than 10% of normal levels.Type II, known as dysprothrombinemia, includes a missense mutation at specific Xa factor cleavage sites and serine protease prothrombin regions. Type II deficiency creates a dysfunctional protein with decreased activity and usually normal or low-normal antigen levels. A vitamin K-dependent clotting factor is seldom seen as a contributor to inherited prothrombin deficiencies, but lack of Vitamin K decreases the synthesis of prothrombin in liver cells.Acquired underlying causes of this condition include severe liver disease, warfarin overdose, platelet disorders, and disseminated intravascular coagulation (DIC). It may also be a rare adverse effect to ceftriaxone. Mechanism
Hypoprothrombinemia is found to present itself as either inherited or acquired, and is a decrease in the synthesis of prothrombin. In the process of inheritance, it marks itself as an autosomal recessive disorder, meaning that both parents must be carriers of the defective gene in order for the disorder to be present in a child.
Polyonychia also known as supernumerary nails is a condition in which two or more nails grow in the same finger or toe. Signs and symptoms
The signs/symptoms of polyonychia are very easy to detect: two or more nails growing on the same finger or toe. The nails can either be separate, small nails (micronychia) or one wide, almost complete nail, the digit affected could also be wider than normal

Causes
Polyonychia is generally caused by a congenital duplication of the distal phalange of the affected digit(s), this can be caused by congenital factors (sporadic without a genetic link) or by genetic factors (sporadic or familial with genetic link). It can also be caused by polysyndactyly, which is characterized as one normal digit being connected/webbed (syndactyly) to an extra digit (polydactyly). Polyonychia can also be acquired, such as after an accident that affected the nail bed causing it to split. This type of polyonychia is just referred to as "post-traumatic split nail" Polyonychias syndromic causes include:

Isolated congenital onychodysplasiaPolyonychias non-syndromic causes include:

Polyphalangism (more specifically of the distal phalange)
Polysyndactyly

See also
Polydactyly
Syndactyly
Polysyndactyly


== References ==