Other clinical signs that could indicate papillary thyroid are fixation to the trachea, a firm neck mass, damage to recurrent laryngeal or cervical sympathetic nerves. Five percent of the population can have thyroid nodules, and the majority will be benign.Appropriate workup includes an ultrasound of the neck, followed by lab studies. Patients will usually meet with both an endocrinologist and a surgeon (head and neck surgeon or endocrine surgeon). Markers
Thyroglobulin can be used as a tumor marker for well-differentiated papillary thyroid cancer. HBME-1 staining may be useful for differentiating papillary carcinomas from follicular carcinomas; in papillary lesions it tends to be positive.Reduced expression of ATP5E is significantly associated with the diagnosis of papillary thyroid cancer and may serve as an early tumor marker of the disease. Serum microRNAs have shown good diagnostic performance for distinguishing patients with papillary thyroid cancer from patients with benign thyroid nodules and healthy controls, and are suggested as novel and minimally invasive diagnostic approach in clinical practice. Pathology
Papillary thyroid cancer gets its name from the papillae among its cells, visible on microscopy. Features include: 

Characteristic Orphan Annie eye nuclear clearings (nuclei with uniform staining, which appear empty due to powdery chromatin and marginal micronucleoli) and psammoma bodies on light microscopy. The former is useful in identifying the follicular variant of papillary thyroid carcinomas. Lymphatic spread is more common than hematogenous spread
Multifocality is common
The so-called lateral aberrant thyroid is usually a lymph node metastasis from a papillary thyroid carcinoma.
Serositis refers to inflammation of the serous tissues of the body, the tissues lining the lungs (pleura), heart (pericardium), and the inner lining of the abdomen (peritoneum) and organs within. It is commonly found with fat wrapping or creeping fat. Causes
Serositis is seen in numerous conditions:
Lupus erythematosus (SLE), for which it is one of the criteria,
Rheumatoid arthritis
Familial Mediterranean fever (FMF)
Chronic kidney failure / Uremia
Juvenile idiopathic arthritis
Inflammatory bowel disease (especially Crohns disease)
Acute appendicitis
Diffuse cutaneous systemic sclerosis

See also
Hyaloserositis

References


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