Medical marijuana was legalized in Mexico in mid-2017; legislators plan to legalize its recreational use by late 2019.On 28 June 2021, Clarence Thomas, one of the U.S. Supreme Courts most conservative justices, possibly opened the door to federal legalization of cannabis in the United States when he wrote "A prohibition on interstate use or cultivation of marijuana may no longer be necessary or proper to support the federal governments piecemeal approach." Legality by country
Currently, Uruguay and Canada are the only countries that have fully legalized the cultivation, consumption and bartering of recreational cannabis nationwide. In the United States, 19 states, 2 territories, and the District of Columbia have legalized the recreational use of cannabis – though the drug remains illegal at the federal level. Laws vary from state to state when it comes to the commercial sale. Court rulings in Georgia and South Africa have led to the legalization of cannabis consumption, but not legal sales. A policy of limited enforcement has also been adopted in many countries, in particular Spain and the Netherlands where the sale of cannabis is tolerated at licensed establishments. Contrary to popular belief, cannabis is not legal in the Netherlands but it has been decriminalized since the 1970s. In 2021, Malta was the first European Union member to legalize the use of cannabis for recreational purposes. In Estonia, it is only legal to sell cannabis products with a THC content of less than 0.2%, although products may contain more cannabidiol.
Cholinergic urticaria (CU) presents with tiny very itchy wheals and small bumps on a reddish background.It is a type of physical urticaria (or hives) that appears when a person is sweating or their core body temperature increases. Symptoms
Cholinergic urticaria typically presents with a number of small, short-lasting hives but may also involve cutaneous inflammation (wheals) and pain which develops usually in response to exercise, bathing, staying in a heated environment, or emotional stress. Although the symptoms subside rapidly, commonly within 1 hour, cholinergic urticaria may significantly impair quality of life, especially in relation to sporting activities. Causes
Sweat hypersensitivity
Acquired anhidrosis and/or hypohidrosis
Idiopathic
Opioid use
Cholinesterase inhibitors

Subtypes
Sweat hypersensitivity
This subtype of CU refers to those who are hypersensitive to their own sweat. Diagnosis
Diagnosis is made by injecting autologous (the persons own) sweat into the skin. Features
The hives are observed to coincide with perspiration points of sweating. Pathophysiology
Tanaka et al. found that the sweat hyper-sensitivities of CU and atopic dermatitis seem to be virtually the same, and therefore, the sweat-induced histamine release from basophils may also be mediated by a specific IgE for sweat in atopic dermatitis as well as CU. Treatment
Proposed first-line treatment: Rapid desensitization protocol using autologous sweat. Non-pharmacological treatment: Forced perspiration by excessive body warming (hot bath or exercise) used daily may reduce the symptoms through exhaustion of inflammatory mediators. This non-pharmacological treatment is contraindicated in those with CU as a result of hypohidrosis (see below).