Adverse effects
The most common adverse effects of short-term use include headache (reported by 7% of people in clinical trials), drowsiness (2%), dizziness (1%), and diarrhea (1%); the most common side effects of long-term use included
drowsiness (8%),
dizziness (5%),
allergy (4%),
sinusitis (4%),
back pain (3%),
diarrhea (3%),
drugged feeling (3%),
dry mouth (3%),
lethargy (3%),
sore throat (3%),
abdominal pain (2%),
constipation (2%),
heart palpitations (2%),
lightheadedness (2%),
rash (2%),
abnormal dreams (1%),
amnesia (1%),
chest pain (1%),
depression (1%),
flu-like symptoms (1%),
and
sleep disorder (1%).Zolpidem increases risk of depression, falls and bone fracture, poor driving, suppressed respiration, and has been associated with an increased risk of death. Upper and lower respiratory infections are also common (experienced by between 1 and 10% of people).Residual hangover effects, such as sleepiness and impaired psychomotor and cognitive function, may persist into the day following nighttime administration. Such effects may impair the ability of users to drive safely and increase risks of falls and hip fractures. Around 3% of people taking zolpidem are likely to break a bone as a result of a fall due to impaired coordination caused by the drug.Some users have reported unexplained sleepwalking while using zolpidem, as well as sleep driving, night eating syndrome while asleep, and performing other daily tasks while sleeping. Research by Australias National Prescribing Service found these events occur mostly after the first dose taken, or within a few days of starting therapy. In February 2008, the Australian Therapeutic Goods Administration attached a boxed warning concerning this adverse effect.
Monitoring Parameters
Seizure frequency, liver function tests , suicidality

History
Tiagabine was discovered at Novo Nordisk in Denmark in 1988 by a team of medicinal chemists and pharmacologists under the general direction of Claus Bræstrup. The drug was co-developed with Abbott Laboratories, in a 40/60 cost sharing deal, with Abbott paying a premium for licensing the IP from the Danish company.U.S. patents on tiagabine listed in the Orange Book expired in April 2016. See also
CI-966
Deramciclane
Nipecotic acid
SKF-89976A

References
External links
Gabitril(manufacturers website)