Aldurazyme is administered as a slow intravenous infusion. The recombinant enzyme is 628 amino acids in length with 6 N-linked oligosaccharide modification sites and two oligosaccharide chains terminating in mannose sugars. Medical use
Aldurazyme is indicated in the US for people with Hurler and Hurler-Scheie forms of Mucopolysaccharidosis I (MPS I) and for people with the Scheie form who have moderate to severe symptoms.Aldurazyme is indicated in the EU for long-term enzyme replacement therapy in patients with a confirmed diagnosis of mucopolysaccharidosis I (MPS I; alpha-L-iduronidase deficiency) to treat the nonneurological manifestations of the disease.Aldurazyme was approved for medical use in the United States and in the European Union in 2003. Pre-clinical work
Dosing for human clinical studies was based on canine MPS I studies. Clinical trials
Three clinical trials were performed to establish the pharmacology, efficacy, and safety of weekly intravenous administration of the drug. These studies included a Phase I open-label study, a Phase III randomized, double-blind, placebo-controlled study, and a Phase III open-label extension study. A Phase II Young Pediatric study was also conducted.Clinical trials and post-market safety data indicate that the most common adverse side effect of Aldurazyme is allergic reaction. In order to prevent allergic reaction and respiratory distress, the packet insert of Aldurazyme suggests that patients be administered antihistamines before infusion. Allergic reaction occurs in approximately 1% of patients. It is recommended that patients who are high-risk for respiratory distress be given their infusion in a facility equipped to deal with an anaphylactic response.
Malassezia folliculitis or Pityrosporum folliculitis,  is a skin condition caused by infection by Malassezia (formerly Pityrosporum) yeast. : 314 The skin of the upper trunk area including the back, chest, arms and sometimes the neck is often affected and this condition is often seen in young to middle aged adults, although it has been known to occur in adults well into their sixties, and can also be found on the lower extremities as well. Its diagnosis is based on the pruritic (itchy) papulopustules found in a follicular pattern in these regions.Pustules are caused by an overgrowth of the yeast (a type of fungus) Malassezia furfur (Pityrosporum ovale), which plugs the follicles. M. furfur is lipophilic, requiring fatty acids like what is present in oily skin to proliferate. It has been shown that Malassezia yeast grows by consuming fatty acids with carbon chain lengths C11 to C24. Pityrosporum is part of the normal skin flora, but overgrows in certain conditions. Overgrowth is associated with oily skin, humidity or other pre-existing dermatologic conditions such as seborrheic dermatitis and severe dandruff. See also
Skin lesion
List of cutaneous conditions


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