Floating–Harbor syndrome, also known as Pelletier–Leisti syndrome, is a rare disease with fewer than 50 cases described in the literature. It is usually diagnosed in early childhood and is characterized by the triad of proportionate short stature with delayed bone age, characteristic facial appearance, and delayed speech development. Although its cause is unknown, it is thought to result from genetic mutation, and diagnosis is established by the presence of a heterozygous SRCAP mutation in those with clinical findings of FHS. Signs and symptoms
Below are the common clinical features of those diagnosed with Floating–Harbor syndrome. Patients will show varying degrees of some or all FHS symptoms. Facial abnormalities  are the most defining aspects of those diagnosed with this disease. Cardinal facial features
Triangular face
Deep-set eyes
Short philtrum
Wide mouth with a thin vermilion border of the upper lip
Long nose with a narrow bridge and broad, bulbous base
Low-set ears

Voice quality and language
Dysarthria and verbal dyspraxia with phoneme imprecision
Hypernasality
High-pitched voices
Severe receptive and expressive language impairment across all domains of function

Bodily features
Significant delay in bone age (-2 SD or greater) with normalization between 6–12 years old
Skeletal anomalies: brachydactyly, broad fingertips or clubbing, clinodactyly, short thumbs, prominent joints, clavicle abnormalities
Short adult stature: for females, maximum height was at the 20th percentile; for males, the maximum height was at the 25th percentile, though male height varied more widelyThe differential diagnosis of broad thumbs includes Rubinstein-taybi syndrome, where they are a cardinal feature.
Keratoconjunctivitis is inflammation ("-itis") of the cornea and conjunctiva. When only the cornea is inflamed, it is called keratitis; when only the conjunctiva is inflamed, it is called conjunctivitis. Causes
There are several potential causes of the inflammation:

Keratoconjunctivitis sicca is used when the inflammation is due to dryness. ("Sicca" means "dryness" in medical contexts.) It occurs with 20% of rheumatoid arthritis patients. The term "vernal keratoconjunctivitis" (VKC) is used to refer to keratoconjunctivitis occurring in spring, and is usually considered to be due to allergens. "Atopic keratoconjunctivitis" is one manifestation of atopy. "Epidemic keratoconjunctivitis" is caused by an adenovirus infection. "Infectious bovine keratoconjunctivitis" (IBK) is a disease affecting cattle caused by the bacteria Moraxella bovis. "Pink eye in sheep and goat" is another infectious keratoconjunctivitis of veterinary concern, mostly caused by Chlamydophila pecorum. "Superior limbic keratoconjunctivitis" is thought to be caused by mechanical trauma. "Keratoconjunctivitis photoelectrica" (arc eye) means inflammation caused by photoelectric UV light. It is a type of ultraviolet keratitis. Such UV exposure can be caused by arc welding without wearing protective eye glass, or by high altitude exposure from sunlight reflected from snow ("snow blindness"). The inflammation will only appear after about 6 to 12 hours. It can be treated by rest, as the inflammation usually heals after 24–48 hours. Proper eye protection should be worn to prevent keratoconjunctivitis photoelectrica. References
External links

eMedicine – on Atopic keratoconjunctivitis
eMedicine – on Epidemic keratoconjunctivitis