Antihistamines are a commonly prescribed first-line treatment for conventional urticaria, but its effectiveness in the treatment of CU is rather limited in most cases. Some research suggests that first-generation antihistamines with anticholinergic properties such as diphenhydramine are most successful at treating CU. Treatment(s) with mixed success: omalizumab (anti-IgE therapy), danazol (synthetic androgen), propranolol (beta blocker), zileuton (antileukotriene). Acquired anhidrosis and/or hypohidrosis
This subtype of CU refers to those who have abnormally reduced sweating. Diagnosis
Sweat is readily visualized by a topical indicator such as iodinated starch or sodium alizarin sulphonate. Both undergo a dramatic colour change when moistened by sweat. A thermoregulatory sweat test evaluates the bodys response to a thermal stimulus by inducing sweating through the use of a hot box ⁄ room, thermal blanket or exercise. Failure of the topical indicator to undergo a colour change during thermoregulatory sweat testing can indicate anhidrosis and/or hypohidrosis (see Minor test).A skin biopsy may reveal cellular infiltrates in sweat glands or ducts. Features
Severe heat intolerance (e.g., nausea, dizziness, and headache), and tingling, pricking, pinchy or burning pain over the entire body on exposure to hot environments or prolonged exercise which improve after cooling the body. Occurs in the absence of any causative skin, metabolic, or neurological disorders. Pathophysiology
The wheals, hypohidrosis, and pain seems to result from the low expression levels of acetylcholinesterase (AchE) and cholinergic receptor, muscarinic 3 (CHRM3) in the eccrine gland epithelial cells.
Penile pain refers to pain in the penis, human or otherwise. Common causes
Penile injury
Circumcision
Penile fracture
Priapism
Phimosis
Peyronies disease
Sexually transmitted infections
Chronic prostatitis/chronic pelvic pain syndrome

Cultural references
Priapus, a minor Greek god of fertility, is marked by his oversized, permanent erection, which gave rise to the medical term priapism. Some researchers believe the depiction of Priapus penis referred to a penile disease, and that paintings of Priapus were used to ward off the disease. See also
Genital pain
Vaginal pain
Testicular pain
List of the causes of genital pain


== References ==