In people in whom the infection worsens into sepsis, typically following ingestion, the mortality rate rises to 50%. The majority of these people die within the first 48 hours of infection. The optimal treatment is not known, but in one retrospective study of 93 people in Taiwan, use of a third-generation cephalosporin and a tetracycline (e.g., ceftriaxone and doxycycline, respectively) was associated with an improved outcome. Prospective clinical trials are needed to confirm this finding, but in vitro data support the supposition that this combination is synergistic against V. vulnificus. Likewise, the American Medical Association and the Centers for Disease Control and Prevention  (CDC) recommend treating the person with a quinolone or intravenous doxycycline with ceftazidime. The first successful documented treatment of fulminant V. vulnificus sepsis was in 1995. Treatment was ceftazidime and intravenous (IV) ciprofloxacin and IV doxycycline, which proved successful. Prevention of secondary infections from respiratory failure and acute renal failure is crucial. Key to the diagnosis and treatment were the early recognition of bullae in an immunocompromised person with liver cirrhosis and oyster ingestion within the previous 48 hours, and the request by the physician for STAT Gram staining and blood cultures for V. vulnificus.Vibrio vulnificus often causes large, disfiguring ulcers that require extensive debridement or even amputation. Prognosis
Vibrio vulnificus may not be a commonly known bacteria, but it is, however, the most common cause of death due to seafood in the United States.
A choriovitelline placenta is a placenta formed by the yolk sac and chorion. In a choriovitelline placenta, the yolk sac fuses with the chorion and, subsequently, wrinkles develop that hold the embryo to the uterine wall, thus forming the choriovitelline placenta. The chorionic blood vessels are connected with the vitelline blood vessel of the yolk sac. It is a primitive type of placenta found in all marsupials. (However, bandicoots also have a chorioallantoic placenta.) A choriovitelline placenta also forms early in the development of some placental mammals before the chorioallantoic placenta forms and the choriovitelline placenta is resorbed. == References ==