In the United States, more than 200 cases were suspected by mid-May, including some 145 in New York; 186 confirmed cases were eventually diagnosed between 15 March and 20 May in 26 US states. As of 11 May 2020, five fatalities were reported (1 in France, 1 in the UK, 3 in the US). In peer-reviewed medical journals, case series and related studies of the new condition were rapidly reported from countries including the UK; Italy; Spain; France and Switzerland; France; and across the US, including New York. The emerging observations suggested somewhat greater variety in the severity of symptoms than was originally thought. The proposal of a new clinical entity during a pandemic also prompted scientific discussion about its possible distinction from Kawasaki disease, and the potential role of COVID-19.By 15 July, 342 confirmed MIS-C cases (including 6 deaths) had been recorded in the US across 36 states plus Washington DC. Most (71%) of the children were Hispanic/Latino or non-Hispanic Black people, and the CDC underlined the need to learn the reasons for such a preponderance. By 29 July, a total of 570 cases and 10 deaths had been reported across 40 states, Washington DC, and New York City.Until late May, no confirmed case had been documented outside the EU/EEA/UK and USA. No suspicious case had been observed in East Asia or Southeast Asia (or in Australia or New Zealand).
Hypopyon is a medical condition involving inflammatory cells in the anterior chamber of the eye. It is an exudate rich in white blood cells, seen in the anterior chamber, usually accompanied by redness of the conjunctiva and the underlying episclera. It is a sign of inflammation of the anterior uvea and iris, i.e. iritis, which is a form of anterior uveitis. The exudate settles at the dependent aspect of the eye due to gravity. It can be sterile (in bacterial corneal ulcer) or not sterile (fungal corneal ulcer). Differential diagnosis
Hypopyon can be present in a corneal ulcer. It can occur as a result of Behçets disease, endophthalmitis, panuveitis/panophthalmitis, or adverse reactions to some drugs (such as rifabutin).Hypopyon is also known as sterile pus because it occurs due to the release of toxins and not by the actual invasion of pathogens. The toxins secreted by the pathogens mediate the outpouring of leukocytes that settle in the anterior chamber of the eye. An inverse hypopyon is different from a standard hypopyon. Inverse hypopyon is seen after a pars plana vitrectomy with an insertion of silicone oil (as a replacement of the vitreous humour that has been removed in the operation; the silicone oil maintains internal tamponade). When the silicone oil emulsifies, it seeps into the anterior chamber and settles at the top of the anterior chamber. This is in contrast to hypopyon resulting from toxins where the leukocytes settle at the bottom of the anterior chamber.