At the time of the reports, Karason maintained his belief in silvers effectiveness and continued to take it, albeit in smaller doses. He died in 2013 of a heart attack; "a cause of death was not immediately known", but according to Jo Anna Karason, his estranged wife, "Paul Karason had suffered heart problems for years. He was a heavy smoker, despite undergoing triple bypass surgery about five years ago".Rosemary Jacobs is a prominent activist against alternative medicine. As a child, Jacobs was treated for allergies with nose drops that contained colloidal silver, and developed argyria as a result. Jacobs came to international attention after Paul Karason was on The Today Show in 2008. From 2010 to 2013, Jacobs posted about topics in health fraud, particularly naturopathy, on her blog. Possible implications
Although research is still not definitive, the literature has suggested that argyria can cause a decrement in kidney function. Additionally, a lack of night vision may be present. The lack of night vision would most likely be due to damaged rods in the eye, from the exposure to silver or silver dust particles in the ocular region. See also
Amalgam tattoo
Bismuthia
Carotenodermia
Chrysiasis
Methemoglobinemia, another condition known for causing blue skin coloration

References
External links

"Public Health Statement for Silver". Centers for Disease Control. December 1990. Retrieved February 24, 2007. "Rosemarys Story." Rosemary Jacobs explains her argyria; includes photographs. Accessed February 24, 2007. "Systemic Argyria Associated With Ingestion of Colloidal Silver." by  Akhil Wadhera, MD and Max Fung, MD. Dermatology Journal Online. Accessed February 24, 1997.
Metanx is a prescription medical food made by Alfasigma that contains L-methylfolate (as Metafolin, a calcium salt of vitamin B9), methylcobalamin (vitamin B12) and pyridoxal 5-phosphate (vitamin B6). It is a vitamin B supplement. Metanx is indicated for the dietary management of peripheral neuropathy (i.e. DPN). Ingredients
Metanx contains the following active ingredients (per capsule):

Folate
L-methylfolate (Metafolin): 3 mg
Pyridoxal 5-phosphate: 35 mg
Methylcobalamin: 2 mg

Indication and usage
Metanx is used for treating:

Painful diabetic neuropathy,
Diabetic foot ulcers,
Endothelial dysfunction  associated with diabetic peripheral neuropathy,
Hyperhomocysteinemia. == References ==