Pharmacokinetics
Following an IV bolus of bivalirudin of 1 mg/kg and a 4-hour 2.5 mg/kg/h IV infusion a mean steady state concentration of 12.3 ± 1.7 µg/mL is achieved
Bivalirudin is cleared from plasma by a combination of renal mechanisms and proteolytic cleavage
Half-life:-Normal renal function (≥ 90 mL/min) = 25 minutes
-Mild renal dysfunction (60–89 mL/min) = 22 minutes
-Moderate renal dysfunction (30-59 mL/min) = 34 minutes
-Severe renal dysfunction (≤ 29 mL/min) = 57 minutes
-Dialysis-dependent  = 3.5 hours

Clearance is reduced approximately 20% in patients with moderate and severe renal impairment and by 80% in dialysis-dependent patients
Bivalirudin is hemodialyzable and approximately 25% is cleared by hemodialysis.PharmacodynamicsCoagulation times return to baseline approximately 1 hour following cessation of bivalirudin administration. Dosing and administration
Bivalirudin is intended for IV use only and is supplied as a sterile, lyophilized product in single-use, glass vials. After reconstitution, each vial delivers 250 mg of bivalirudin. US dosing:
PCI Bolus: 0.75 mg/kg
PCI Infusion: 1.75 mg/kg/hEU dosing:
UA/NSTEMI-Bolus: 0.1 mg/kg
-Infusion: 0.25 mg/kg/h for up to 72 hours for medical management
-If patient proceeds to PCI, an additional bolus of 0.5 mg/kg of bivalirudin should be administered before the procedure and the infusion increased to 1.75 mg/kg/h for the duration of the procedure. PCI-Bolus: 0.75 mg/kg
-Infusion: 1.75 mg/kg/h

Coronary Artery Bypass Graft (CABG)-Patients proceeding to CABG surgery off-pump:
The IV infusion of bivalirudin should be continued until the time of surgery. Just prior to surgery, a 0.5 mg/kg bolus dose should be administered followed by a 1.75 mg/kg/h infusion for the duration of the surgery.
Penile pain refers to pain in the penis, human or otherwise. Common causes
Penile injury
Circumcision
Penile fracture
Priapism
Phimosis
Peyronies disease
Sexually transmitted infections
Chronic prostatitis/chronic pelvic pain syndrome

Cultural references
Priapus, a minor Greek god of fertility, is marked by his oversized, permanent erection, which gave rise to the medical term priapism. Some researchers believe the depiction of Priapus penis referred to a penile disease, and that paintings of Priapus were used to ward off the disease. See also
Genital pain
Vaginal pain
Testicular pain
List of the causes of genital pain


== References ==