History
Antiphospholipid syndrome was described in full in the 1980s, by E. Nigel Harris and Aziz Gharavi. They published the first papers in 1983. The syndrome was referred to as "Hughes syndrome" among colleagues after the rheumatologist Graham R.V. Hughes (St. Thomas Hospital, London, UK), who brought together the team. Research
APS ACTION (the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking), is the first-ever international research network that has been created to design and conduct large-scale, multicenter clinical trials in persistently antiphospholipid antibody (aPL) positive patients. The network consists of a multidisciplinary group of physicians and investigators from around the world who are interested in antiphospholipid syndrome (APS) research. The primary mission of APS ACTION is to prevent, treat, and cure antiphospholipid antibody (aPL) associated clinical manifestations through high quality, multicenter, and multidisciplinary clinical research. References
Bibliography
Triona Holden (2003). Positive Options for Antiphospholipid Syndrome (APS): Self-Help and Treatment. Hunter House (CA). ISBN 978-0-89793-409-1. Kay Thackray (2003). Sticky Blood Explained. Braiswick. ISBN 978-1-898030-77-5. A personal account of dealing with the condition. Graham R V Hughes (2009). Understanding Hughes Syndrome: Case Studies for Patients. Springer. ISBN 978-1-84800-375-0. 50 case studies to help you work out whether you have it. External links
Antiphospholipid Syndrome Explained - Genome.gov
Cyclotropia is a form of strabismus in which, compared to the correct positioning of the eyes, there is a torsion of one eye (or both) about the eyes visual axis. Consequently, the visual fields of the two eyes appear tilted relative to each other. The corresponding latent condition – a condition in which torsion occurs only in the absence of appropriate visual stimuli – is called cyclophoria. Cyclotropia is often associated with other disorders of strabism, can result in double vision, and can cause other symptoms, in particular head tilt.In some cases, subjective and objective cyclodeviation may result from surgery for oblique muscle disorders; if the visual system cannot compensate for it, cyclotropia and rotational double vision (cyclodiplopia) may result. The role of cyclotropia in vision disorders is not always correctly identified. In several cases of double vision, once the underlying cyclotropia was identified, the condition was solved by surgical cyclotropia correction.Conversely, artificially causing cyclotropia in cats leads to reduced vision acuity, resulting in a defect similar to strabismic amblyopia. Diagnosis
Cyclotropia can be detected using subjective tests such as the Maddox rod test, the Bagolini striated lens test, the phase difference haploscope of Aulhorn, or the Lancaster red-green test (LRGT). Among these, the LRGT is the most complete. Cyclotropia can also be diagnosed using a combination of subjective and objective tests. Before surgery, both subjective and objective torsion should be assessed.Experiments have also been made on whether cyclic deviations can be assessed by purely photographic means.