The results of this research could open to possible therapies with drugs that inhibit this protein, such as crizanlizumab. Prognosis
The most common length of survival following diagnosis is 10 to 13 months, with fewer than 1 to 3% of people surviving longer than five years. In the United States between 2012 and 2016 five-year survival was 6.8%. Without treatment, survival is typically 3 months. Complete cures are extremely rare, but have been reported.Increasing age (> 60 years) carries a worse prognostic risk. Death is usually due to widespread tumor infiltration with cerebral edema and increased intracranial pressure.A good initial Karnofsky performance score (KPS) and MGMT methylation are associated with longer survival. A DNA test can be conducted on glioblastomas to determine whether or not the promoter of the MGMT gene is methylated. Patients with a methylated MGMT promoter have longer survival than those with an unmethylated MGMT promoter, due in part to increased sensitivity to temozolomide. Another positive prognostic marker for glioblastoma patients is mutation of the IDH1 gene, which can be tested by DNA-based methods or by immunohistochemistry using an antibody against the most common mutation, namely IDH1-R132H.More prognostic power can be obtained by combining the mutational status of IDH1 and the methylation status of MGMT into a two-gene predictor.
Stress may refer to:

Science and medicine
Stress (biology), an organisms response to a stressor such as an environmental condition
Stress (linguistics), relative emphasis or prominence given to a syllable in a word, or to a word in a phrase or sentence
Stress (mechanics), the internal forces that neighboring particles of a continuous material exert on each other
Occupational stress, stress related to ones job
Psychological stress, a feeling of strain and pressure
Surgical stress, systemic response to surgical injury

Arts, entertainment, and media
Music
Groups and musicians
Stress (Brazilian band), a Brazilian heavy metal band
Stress (British band), a British rock band
Stress (pop rock band), an early 1980s melodic rock band from San Diego
Stress (musician) (born 1977), hip hop singer from Switzerland
Stress (record producer) (born 1979), artistic name of Can Canatan, Swedish musician and record producer

Albums
Stress (Anonymus album), 1997
Stress (Daddy Freddy album), 1991
Stress (Stress album), self-titled album by Brazilian band Stress
Stress: The Extinction Agenda, 1994 album by Organized Konfusion

Songs
"Stress" (Justice song), 2007 song by Justice
"Stress" (Odd Børre song), 1968 song by Odd Børre
"Stress", a song by Godsmack from Godsmack
"Stress", a 2000 song by Jims Big Ego
"The Stress", a 1989 song by Chisato Moritaka

Other music
Stress (music), a type of emphasis placed on a particular note or set of notes

Other arts, entertainment, and media
Stress (card game), a card game
Stress (journal), a medical journal
"Stress" (The Unit), an episode of the television series The Unit

Other uses
Stress (font), varying stroke widths of a font

See also
All pages with titles containing Stress
Emphasis (disambiguation)
Stress cracking (disambiguation)
Stress intensity (disambiguation)
Stress tensor (disambiguation)
Stress test (disambiguation)
Tension (disambiguation)