It may include: [4] [5]
Supplemental formulas and/or gastrostomy tube placement to meet nutritional needs and improve the growth delay,Ongoing physical, occupational, and speech therapies,Surgery to treat skeletal abnormalities, gastrointestinal problems, congenital heart defects and other health problems, and,
Medications to prevent or control seizures.Research into CdLS ongoing

History
The first documented case was in 1916 by Winfried Robert Clemens Brachmann (1888–1969), a German physician who wrote about the distinct features of the disease from his 19-year-old patient, followed in 1933 by Cornelia Catharina de Lange (1871–1950), a Dutch pediatrician after whom the disorder has been named. CdLS was formerly known as Brachmann-de Lange Syndrome. References
External links

GeneReviews/NCBI/UW/NIH entry on Cornelia de Lange syndrome
Malik, Lamees Mahmood; Khan, Ghazala Aziz; Azfar, Nadia Ali; Jahangir, Muhammad (2011). "Cornelia de Lange Syndrome - a cause of hypertrichosis in children: case report and review of literature". Journal of Pakistan Association of Dermatologists. 21 (3): 211–214. Gale A270898918.
Radcliffe Crocker, in 1889, then described EMPD following an observation of a patient with urinary carcinoma affecting the penis and scrotum, showing symptoms that were almost identical to MPD as described by Paget. Later in 1893, Darier and Coulillaud described the perianal location of EMPD. References
External links
Definition at cancer.org