Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of severe acne vulgaris. It consists of a combination of adapalene and benzoyl peroxide in a topical gel formulation. Medical uses
Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris. Side effects
Commonly reported side effects include the following:
Skin redness
Scaling
Dry skin
Contact dermatitis
Skin irritation
Stinging
Burning

Research
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002). References
External links
"Adapalene mixture with benzoyl peroxide". Drug Information Portal. U.S. National Library of Medicine.
A amoebic liver abscess is a type of liver abscess caused by amebiasis. It is the involvement of liver tissue by trophozoites of the organism Entamoeba histolytica and of its abscess due to necrosis. Presentation
Approximately 90% of patients with E histolytica are asymptomatic. The two most common manifestations of E histolytica include colitis (bloody stool with mucus, abdominal pain, and/or diarrhea), and discovery of a liver abscess on imaging. Liver abscess commonly present as right upper quadrant abdominal pain and fever, with worsening features associated with abscess rupture. Symptoms
Pain right hypochondrium referred to the right shoulder
Pyrexia (100.4 F)
Profuse sweating and rigors
Loss of weight
Earthy complexion

Signs
Pallor
Tenderness and rigidity in right hypochondrium
Palpable liver
Intercostal tenderness
Basal lung signs

Diagnosis
Diagnosis is primarily made by identifying stool ova and parasites on stool antigen testing in the presence of colitis, or E histolytica serology. Blood ceruloplasmin
Haemoglobin estimation
Stools examination (trophozoites and cysts)
Radiography
Aspiration exploratory
Medical ultrasonography and CT scanning
Sigmoidoscopy
Liver function tests
Serological tests

Rodent models
Due to the difficulty of exploring host and amebic factors involved in the pathogenesis of amebic liver abscess in humans, most studies have been conducted with animal models (e.g., mice, gerbils, and hamsters). Histopathological findings revealed that the chronic phase of amebic liver abscess in humans corresponds to lytic or liquefactive necrosis, whereas in rodent models there is granulomatous inflammation. However, the use of animal models has provided important information on molecules and mechanisms of the host/parasite interaction in amebic liver abscess. References


== External links ==