The embryo, then the fetus and then the baby will have what is called a 45,X/46,XY constitution. This is called a
mosaic karyotype because, like tiles in mosaic floors or walls, there is more than one type of cell.There are many chromosomal variations that cause the 45,X/46,XY karyotype, including malformation (isodicentricism) of the Y chromosomes, deletions of Y chromosome or translocations of Y chromosome segments. These rearrangements of the Y chromosome can lead to partial expression of the SRY gene which may lead to abnormal genitals and testosterone levels. Diagnosis
Identification of 45,X/46,XY karyotype has significant clinical implications due to known effects on growth, hormonal balance, gonadal development and histology. 45,X/46,XY is diagnosed by examining the chromosomes in a blood sample. The age of diagnosis varies depending on manifestations of disease prompting reason for cytogenetic testing. Many patients are diagnosed prenatally due to fetal factors (increased nuchal fold, or abnormal levels of serum), maternal age or abnormal ultrasounds, while others will be diagnosed postnatal due to external genital malformation. It is not uncommon for patients to be diagnosed later in life due to short stature or delayed puberty, or a combination of both.45,X/46,XY mosaicism can be detected prenatally through amniocentesis however, it was determined that the proportion of 45,X cells in the amniotic fluid cannot predict any phenotypic outcomes, often making prenatal genetic counselling difficult. Management
See also
Gonadal dysgenesis
Mosaic (genetics)
Turner syndrome

References


== External links ==
Anacin is an American brand of analgesic that is manufactured by Prestige Consumer Healthcare. Its product contains aspirin and caffeine. History
Anacin was invented by William Milton Knight and was first to be used circa 1916 as stated in the patent. Anacin is one of the oldest brands of pain relievers in the United States, first being sold in the 1930s. Anacins mascot at the time was Ana Anacin, who was found in a number of ads for this product by Bayer. It was originally sold by the Anacin Co. ("Pharmaceutical Chemists") in Chicago, Illinois. American Home Products, now known as Wyeth, purchased the manufacturing rights in 1930. Anacin was reportedly their most popular product. Insight Pharmaceuticals acquired the brand in 2003. In 2014, Prestige Brands signed an agreement with Insight to acquire the company; it was Prestige Brands largest acquisition to that point. Advertising
In 1939, Anacin sponsored a daytime serial called Our Gal Sunday. Their sponsorship spanned 18 of the programs 23 years on the air. Early Anacin radio commercials appeared in radio shows and dramas of the 1940s and 50s. These "formulaic" commercials usually claimed that Anacin was being actively prescribed by doctors and dentists at the time, treated "headaches, neuritis and neuralgia", and that it contained "a combination of medically proven ingredients, like a doctors prescription", without specifying those ingredients. Sometimes the announcer would mention that there were four active ingredients in Anacin, one of which was the medicine the consumer was already taking. It also claimed to help with depression.