Infections of domestic dogs have been particularly common in Chad, where they helped reignite dracunculiasis transmission in 2010. Dogs are thought to be infected by eating a paratenic host, likely a fish or amphibian. As with humans, prevention efforts have focused on preventing infection by encouraging people in affected areas to bury fish entrails as well as to identify and tie up dogs with emerging worms so that they cannot access drinking water sources until after the worms have emerged. Domestic ferrets can be infected with D. medinensis in laboratory settings, and have been used as an animal disease model for human dracunculiasis.Different Dracunculus species can infect snakes, turtles, and other mammals. Animal infections are most widespread in snakes, with nine different species of Dracunculus described in snakes in the United States, Brazil, India, Vietnam, Australia, Papua New Guinea, Benin, Madagascar, and Italy. The only other reptile affected is the snapping turtle with infected common snapping turtles described in several U.S. states, and a single infected South American snapping turtle described in Costa Rica. Infections of other mammals are limited to the Americas. Raccoons in the U.S. and Canada are most widely impacted, particularly by D. insignis; however, Dracunculus worms have also been reported in American skunks, coyotes, foxes, opossums, domestic dogs, domestic cats, and (rarely) muskrats and beavers. Notes
References
Works cited
External links

"Guinea Worm Disease Eradication Program". Carter Center.
Tiotixene, or thiothixene, sold under the brand name Navane among others, is a typical antipsychotic of the thioxanthene class which is related to chlorprothixene and is used in the treatment of psychoses like schizophrenia and bipolar mania. It was introduced in the United States in 1967 by Pfizer.Tiotixene is also related to thioproperazine and pipotiazine, members of the phenothiazine class. Pharmacology
Pharmacodynamics
Tiotixene acts primarily as a highly potent antagonist of the dopamine D2 and D3 receptors (subnanomolar affinity). It is also an antagonist of the histamine H1, α1-adrenergic, and serotonin 5-HT7 receptors (low nanomolar affinity), as well as of various other receptors to a much lesser extent (lower affinity). It does not have any anticholinergic activity. Antagonism of the D2 receptor is thought to be responsible for the antipsychotic effects of tiotixene. History
Tiotixene was introduced in 1967. Chemistry
Tiotixene is a member of the thioxanthene class of antipsychotics. Analogues include chlorprothixene, clopenthixol, flupentixol, and zuclopenthixol. == References ==