Peyronies disease is a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis. Specifically, scar tissue forms in the tunica albuginea, the thick sheath of tissue surrounding the corpora cavernosa, causing pain, abnormal curvature, erectile dysfunction, indentation, loss of girth and shortening.It is estimated to affect between .4 to 20% of men. The condition becomes more common with age. Signs and symptoms
A certain degree of curvature of the penis is considered normal, as many people are born with this benign condition, commonly referred to as congenital curvature. The disease may cause pain; hardened, big, cord-like lesions (scar tissue known as "plaques"); or abnormal curvature of the penis when erect due to chronic inflammation of the tunica albuginea (CITA).Although the popular conception of Peyronies disease is that it always involves curvature of the penis, the scar tissue sometimes causes divots or indentations rather than curvature. The condition may also make sexual intercourse painful and/or difficult, though it is unclear whether some men report satisfactory or unsatisfactory intercourse in spite of the disorder. The disorder is confined to the penis, although a substantial number of men with Peyronies exhibit concurrent connective tissue disorders in the hand, and to a lesser degree, in the feet. About 30 percent of men with Peyronies disease develop fibrosis in other elastic tissues of the body, such as on the hand or foot, including Dupuytrens contracture of the hand. An increased incidence in genetically related males suggests a genetic component.
In addition to being an antifungal, butenafine is an anti inflammatory. Because fungal skin infections are often accompanied by significant inflammation, this is a desirable property. The fact that butenafine has intrinsic anti inflammatory properties is also desirable since  it is not necessary to add cortical steroids (which decrease the ability to fight infection) to reduce inflammation. Chemistry
Butenafine hydrochloride is an odorless white crystalline powder that is freely soluble in methanol, ethanol, and chloroform, and slightly soluble in water. == References ==