It is also used for toxoplasmosis in people unable to tolerate trimethoprim with sulfamethoxazole.Dapsone by mouth was one of the first medications used to treat moderate to severe acne vulgaris, and is still occasionally prescribed for the treatment of severe cases. A topical form of dapsone is also effective with potentially less side effects.It is unclear if the combination with pyrimethamine is useful in the prevention of malaria. Autoimmune disease
Cutaneous lupus erythematosis. Dapsone is effective and safe in persons with moderate, severe, or refractory cutaneous lupus erythematosis. Idiopathic thrombocytopenic purpura. Dapsone is effective and safe for adjunctive glucocorticoid-sparing treatment of persons with idiopathic thrombocytopenic purpura and is preferred over danazol or interferon alpha in those people with antinuclear antibodies. Chronic spontaneous urticaria. Dapsone is effective and safe for treatment of second-line therapy for people with chronic spontaneous urticaria in those for whom antihistamines and other first-line agents have failed. Relapsing polychondritis. There are no clinical trials but there are many case reports that dapsone is effective at doses of 25 mg/day to 200 mg/day for treatment of relapsing polychondritis. Other
Dermatitis herpetiformis in combination with a gluten-free diet.Dapsone may be used to treat brown recluse spider bites that become necrotic.Dapsone is the recommended treatment for erythema elevatum diutinum, as a review found that using oral dapsone alone was effective in 80% of early cases of the disease.
Trichoepithelioma is a neoplasm of the adnexa of the skin. Its appearance is similar to basal cell carcinoma. One form has been mapped to chromosome 9p21. Types
Trichoepitheliomas may be divided into the following types:: 672 
Multiple familial trichoepithelioma
Solitary trichoepithelioma
Desmoplastic trichoepithelioma

Pathology
Trichoepitheliomas consists of nests of basaloid cells, with palisading. They lack the myxoid stroma and artefactual clefting seen in basal cell carcinoma. Mitoses are uncommon when compared to basal cell carcinoma. Diagnosis
Trichoepiteliomas often contain Merkel cells; an immunostain for CK20 can be used to demonstrate this. See also
Trichoblastoma
Pilomatricoma
CYLD cutaneous syndrome
List of cutaneous conditions
List of cutaneous neoplasms associated with systemic syndromes

References


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