Community access
Schools, government agencies, and nonprofit organizations hold training programs to educate laypeople on the proper use of naloxone and to send them home with medicine. It is estimated that programs like these have helped to reverse more than 26,000 overdoses in the US. Harm reduction organizations providing needle and syringes to those injecting drugs have been particularly involved in naloxone distribution, purchasing medicine at discounted rates through a Buyers Club and distributing more than 3 million vials to those at high risk or likely to be with those at high risk between 2017 and 2020 alone. In a survey of US laypersons in December 2021, most people believed the scientifically-supported idea that trained bystanders can reverse overdoses with naloxone.A survey of US naloxone prescription programs in 2010 revealed that 21 out of 48 programs reported challenges in obtaining naloxone in the months leading up to the survey, due mainly to either cost increases that outstripped allocated funding or the suppliers inability to fill orders. The approximate cost of a 1 ml ampoule of naloxone in the US is estimated to be significantly higher than in most other countries.Take-home naloxone programs for people who use opioids is under way in many North American cities. CDC estimates that the US programs for drug users and their caregivers prescribing take-home doses of naloxone and training on its use  prevented 10,000 opioid overdose deaths by 2014.In Australia, as of February 1, 2016, some forms of naloxone are available "over the counter" in pharmacies without a prescription.
A "flare" is a spreading area of redness or flush. It is the second reaction in the triple response to injury and is due to dilatation of the arteriole. When this flare occurs around the ankle, it is called an ankle flare. The condition is also known as a malleolar flare, in reference to the malleolus, the bony prominence on each side of the ankle. Ankle flares are often caused by venous ulcer, due to deep vein thrombosis or varicose veins. It is considered to be an early sign of advanced venous disease. Treatment involves management of the underlying condition, along with supportive care. See also
Corona phlebectatica


== References ==