It has been found that GABA reversal potential is depolarising in the subpopulation of the pyramidal cells due to the lack of KCC2 co-transporter. It has been shown that it is theoretically possible to generate seizures in the neural networks due to down-regulation of KCC2, consistent with the chloride measurements during the transition to seizure and KCC2 blockade experiments. Granule cell dispersion in the dentate gyrus
Granule cell dispersion is a type of developmental migration and a pathological change found in the TLE brain which was first described in 1990. The granule cells of the dentate gyrus are tightly packed forming a uniform, laminated layer with no monosynaptic connections. This structure provides a filter for the excitability of neurons.In TLE, granule cells are lost, the structure is no longer closely packed and there are changes in the orientation of dendrites. These changes may or may not be epileptogenic. For instance, if the dendrites of granule cells reconnect, it may be in a way (through the laminar planes) that allows hyperexcitability. However, not all patients have granule cell dispersion. : 387–389

Aberrant mossy fiber sprouting
Mossy fibers are the axons of granule cells. They project into the hilus of the dentate gyrus and stratum lucidum in the CA3 region giving inputs to both excitatory and inhibitory neurons.In the TLE brain, where granule cells are damaged or lost, axons, the mossy fibres, sprout in order to reconnect to other granule cell dendrites. This is an example of synaptic reorganization.
Hair follicle nevus is a cutaneous condition that presents as a small papule from which fine hairs protrude evenly from the surface. See also
Skin lesion
List of cutaneous conditions


== References ==