Phenylephrine is a medication primarily used as a decongestant, to dilate the pupil, to increase blood pressure, and to relieve hemorrhoids. It was long maintained that when taken orally as a decongestant, it relieves nasal congestion due to colds and hay fever. Phenylephrine can be taken by mouth, as a nasal spray, given by injection into a vein or muscle, or applied to the skin.Common side effects when taken by mouth or injected include nausea, vomiting, headache, and anxiety. Use on hemorrhoids is generally well tolerated. Severe side effects may include a slow heart rate, intestinal ischemia, chest pain, kidney failure, and tissue death at the site of injection. It is unclear if use during pregnancy or breastfeeding is safe. Phenylephrine is a selective α1-adrenergic receptor agonist which results in the constriction of both arteries and veins.Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication. Unlike pseudoephedrine, abuse of phenylephrine is very uncommon.As of 2022, there is push back on the effectiveness of phenylephrine as a decongestant, often fused with the supposition that phenylephrine is coasting on its historical status within the Food and Drug Administrations regulatory sphere as an established substitute for the proven use of pseudoephedrine as a decongestant, whose availability has been restricted by law due to its use in the illicit synthesis of methamphetamine. Medical uses
Decongestant
Phenylephrine is used as a decongestant sold as an oral medicine or as a nasal spray.
Desoximetasone is a medication belonging to the family of medications known as topical corticosteroids. It is used for the relief of various skin conditions, including rashes. It helps to reduce redness, itching, and irritation. Desoximetasone is a synthetic corticosteroid, a class of primarily synthetic steroids used as anti-inflammatory  and anti-pruritic  agents. Three brand name products are available (availability depending on country):

Topicort Emollient Cream (0.25% desoximetasone)
Topicort LP Emollient Cream  (0.05% desoximetasone)
Topisolone Cream  (0.25% desoximetasone)

Usage
When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. Large amounts of desoximetasone should be avoided over large areas. It should not be used for extended periods of time. Treated areas should not be covered with airtight dressings such as plastic wrap or adhesive bandages. Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes. Desoximetasone can also be used to treat some types of psoriasis. See also
Clobetasol propionate
Dexamethasone

References
External links
Topicort general info
Topicort usage info