1885 Karl Benz built (and subsequently patented) the first automobile, powered by his own four-stroke cycle gasoline engine in Mannheim, Germany
1885 Otto Lilienthal began experimental gliding and achieved the first sustained, controlled, reproducible flights. 1903 Wright brothers flew the first controlled, powered aircraft
1907 First helicopters Gyroplane no.1 (tethered) and Cornu helicopter (free flight)
1928 Opel RAK.1 rocket car
1929 Opel RAK.1 rocket glider
1961 Vostok vehicle carried the first human, Yuri Gagarin, into space
1969 Apollo Program first crewed vehicle landed on the moon
2010 The number of road motor vehicles in operation worldwide surpassed the 1 billion mark – roughly one for every seven people. Types of vehicles
There are over 1 billion bicycles in use worldwide. In 2002 there were an estimated 590 million cars and 205 million motorcycles in service in the world. At least 500 million Chinese Flying Pigeon bicycles have been made, more than any other single model of vehicle. The most-produced model of motor vehicle is the Honda Super Cub motorcycle, having passed 60 million units in 2008. The most-produced car model is the Toyota Corolla, with at least 35 million made by 2010. The most common fixed-wing airplane is the Cessna 172, with about 44,000 having been made as of 2017. The Soviet Mil Mi-8, at 17,000, is the most-produced helicopter. The top commercial jet airliner is the Boeing 737, at about 10,000 in 2018. At around 14,000 for both, the most produced trams are the KTM-5 and Tatra T3. The most common trolleybus is ZiU-9.
Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue.The term "collagen disease" was coined by Dr. Alvin F. Coburn in 1932, on his quest to discover streptococcal infection as the cause for rheumatic fever. See also
Collagenopathy, types II and XI
Connective tissue disease

References
External links
Collagen disease entry in the public domain NCI Dictionary of Cancer Terms
 This article incorporates public domain material from the U.S. National Cancer Institute document: "Dictionary of Cancer Terms".