Peripheral neuropathy occurs in 10% of patients. Enlargement of the lymph nodes, spleen, and/or liver are present in 30–40% of cases. Other possible signs and symptoms include blurring or loss of vision, headache, and (rarely) stroke or coma. Causes
Waldenström macroglobulinemia is characterized by an uncontrolled clonal proliferation of terminally differentiated B lymphocytes. The most commonly associated mutations, based on whole-genome sequencing of 30 patients, are a somatic mutation in MYD88 (90% of patients) and a somatic mutation in CXCR4 (27% of patients). CXCR4 mutations cause symptomatic hyperviscosity syndrome and high bone marrow activity characteristic of the disease. However, CXCR4 mutation is not associated with splenomegaly, high platelet counts, or different response to therapy, questioning the relevance of CXCR4 in treating patients. An association has been demonstrated with the locus 6p21.3 on chromosome 6. There is a two- to threefold increased risk of Waldenström macroglobulinemia in people with a personal history of autoimmune diseases with autoantibodies, and a particularly elevated risk associated with liver inflammation, human immunodeficiency virus, and rickettsiosis.There are genetic factors, with first-degree relatives of Waldenström macroglobulinemia patients shown to have a highly increased risk of also developing the disease. There is also evidence to suggest that environmental factors, including exposure to farming, pesticides, wood dust, and organic solvents, may influence the development of Waldenström macroglobulinemia. Genetics
Although believed to be a sporadic disease, studies have shown increased susceptibility within families, indicating a genetic component. A mutation in gene MYD88 has been found to occur frequently in patients.
Several types of volcanic eruptions—during which lava, tephra (ash, lapilli, volcanic bombs and volcanic blocks), and assorted gases are expelled from a volcanic vent or fissure—have been distinguished by volcanologists. These are often named after famous volcanoes where that type of behavior has been observed. Some volcanoes may exhibit only one characteristic type of eruption during a period of activity, while others may display an entire sequence of types all in one eruptive series. There are three different types of eruptions: 

Magmatic eruptions are the most well-observed type of eruption. They involve the decompression of gas within magma that propels it forward. Phreatic eruptions are driven by the superheating of steam due to the close proximity of magma. This type exhibits no magmatic release, instead causing the granulation of existing rock. Phreatomagmatic eruptions are driven by the direct interaction of magma and water, as opposed to phreatic eruptions, where no fresh magma reaches the surface.Within these wide-defining eruptive types are several subtypes. The weakest are Hawaiian and submarine, then Strombolian, followed by Vulcanian and Surtseyan. The stronger eruptive types are Pelean eruptions, followed by Plinian eruptions; the strongest eruptions are called Ultra-Plinian. Subglacial and phreatic eruptions are defined by their eruptive mechanism, and vary in strength.