History
Vortioxetine was discovered by scientists at Lundbeck who reported the rationale and synthesis for the drug (then called Lu AA21004) in a 2011 paper.In 2007, the compound was in Phase II clinical trials, and Lundbeck and Takeda entered into a partnership in which Takeda paid Lundbeck $40 million up-front, with promises of up to $345 million in milestone payments, and Takeda agreed to pay most of the remaining cost of developing the drug. The companies agreed to co-promote the drug in the US and Japan, and that Lundbeck would receive a royalty on all such sales. The deal included another drug candidate, tedatioxetine (Lu AA24530), and could be expanded to include two other Lundbeck compounds.Vortioxetine was approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder (MDD) in adults in September 2013, and it was approved in Europe later that year. Society and culture
It is made by the pharmaceutical companies Lundbeck and Takeda. Names
Vortioxetine was previously sold under the brand name Brintellix in the United States, but on May 2, 2016, the US FDA approved a name change to Trintellix in order to avoid confusion with the blood-thinning medication Brilinta (ticagrelor). Research
Vortioxetine was under development for the treatment of generalized anxiety disorder and attention-deficit hyperactivity disorder (ADHD) but development for these indications was discontinued. As of August 2021, vortioxetine remains in development for the treatment of anxiety disorders, binge-eating disorder, and bipolar disorder. It is in phase II clinical trials for these indications.
Convex or convexity may refer to:

Science and technology
Convex lens, in optics

Mathematics
Convex set, containing the whole line segment that joins points
Convex polygon, a polygon which encloses a convex set of points
Convex polytope, a polytope with a convex set of points
Convex metric space, a generalization of the convexity notion in abstract metric spaces
Convex function, when the line segment between any two points on the graph of the function lies above or on the graph
Convex conjugate, of a function
Convexity (algebraic geometry), a restrictive technical condition for algebraic varieties originally introduced to analyze Kontsevich moduli spaces

Economics and finance
Convexity (finance), second derivatives in financial modeling generally
Convexity in economics
Bond convexity, a measure of the sensitivity of the duration of a bond to changes in interest rates
Convex preferences, an individuals ordering of various outcomes

Other uses
Convex Computer, a former company that produced supercomputers

See also
List of convexity topics
Non-convexity (economics), violations of the convexity assumptions of elementary economics
Obtuse angle
All pages with titles beginning with Convex