Evolution
It is theorized that the virus may have originated from an ancestral virus in the mid-1500s in the Malay Archipelago region and evolved there into five different genotypes which spread across Asia. The mean evolutionary rate has been estimated to be 4.35×10−4 (range: 3.49×10−4 to 5.30×10−4) nucleotide substitutions per site per year. References


== External links ==
Onychomatricoma is a cutaneous condition characterized by a distinctive tumor of the nail matrix.This nail disease can mimic many nail problems and should be examined and biopsied by a dermatologist. In particular, a main concern is the malignant and destructive potential that may exist. See also
Nail anatomy
List of cutaneous conditions
Nail disease


== References ==