Escherichia coli
Proteus mirabilis
Klebsiella pneumoniae
Enterobacter species
Coagulase-negative Staphylococcus species, including S. saprophyticus
Streptococcus pneumoniae
Haemophilus influenzae

Side effects
Common
Nauseas
Change in taste
Vomiting
Diarrhea
Rashes
Sun sensitivity
Itchiness

Rare
Can cause thrombocytopenia (low levels of platelets) by lowering folic acid levels; this may also cause megaloblastic anemia. Trimethoprim antagonizes the epithelial sodium channel  in the distal tubule, thus acting like amiloride. This can cause increased potassium levels in the body (hyperkalemia). Can compete with creatinine for secretion into the renal tubule. This can cause an artificial rise in the serum creatinine. Use in EHEC infections may lead to an increase in expression of Shiga toxin. Contraindications
Known hypersensitivity to trimethoprim
History of megaloblastic anemia due to folate deficiency

Pregnancy
Based on the studies that show that trimethoprim crosses the placenta and can affect folate metabolism, there has been growing evidence of the risk of structural birth defects associated with trimethoprim, especially during the first trimester of pregnancy. It may be involved in a reaction similar to disulfiram when alcohol is consumed after it is used, in particular when used in combination with sulfamethoxazole. The trophoblasts in the early fetus are sensitive to changes in the folate cycle. A recent study has found a doubling in the risk of miscarriage in women exposed to trimethoprim in the early pregnancy. Mechanism of action
Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
These types of accidents resulted in over half of all recorded deaths. Common injuries
Slips, trips and falls account for over a third of all injuries that happen at work. Incorrect handling of items was the most common cause of injuries that led to absences from work of more than 7 days. In 2010–2011, injuries to the upper limb injuries made up 47% of non-fatal injuries at work in the UK.In all, over 1,900,000 working days were lost in 2013–2014 due to slips, trips and falls. Employees at risk
Unsurprisingly, occupation is the biggest influence on the risk of workplace injuries. Workers new to the job are at a much higher risk of injury than more experienced staff, while shift workers and part-time staff also have a greater risk of being injured at work. Employer prosecutions
The Health & Safety Executive (HSE) prosecuted 582 cases in 2013–2014, with at least one conviction secured in 547 cases (94%).Local authorities prosecuted a total of 92 cases during the same period, with at least one conviction achieved in 89 cases (97%).A total of 13,790 notices were issued by the HSE and local authorities, with over £16,700,000 issued in fines. Taiwan
Traumatic injuries to the upper limbs are the most frequent type of injury at work in Taiwan. In 2010, there were 14,261 occupational injuries recorded in 2010 and 45% of these involved trauma to the upper limbs.