The most common presentation of 45,X/46,XY karyotype is phenotypically normal male, next being genital ambiguity.There is a range of chromosomal anomalies within 45,X/46,XY where the variations are very complex, and the actual result in living individuals is often not a simple picture. Most patients with this karyotype are known to have abnormal gonadal histology and heights considerably below their genetic potential. High gonadotropin levels have been described in both male and female patients, as well as low levels of testosterone in male patients. Dosage loss of SHOX gene is commonly associated with short stature. Psychomotor development is normal. As the gonads may not be symmetrical, the development of the Müllerian duct and Wolffian duct may be asymmetrical, too. Because of the presence of dysgenetic gonadal tissue and Y chromosome material, there is a high risk of the development of a gonadoblastoma. Causes
In a normal situation, all the cells in an individual will have 46 chromosomes with one being an X and one a Y or with two Xs. However, sometimes during this complicated early copying process (DNA replication and cell division), one chromosome can be lost. In 45,X/46,XY, most or all of the Y chromosome is lost in one of the newly created cells. All the cells then made from this cell will lack the Y chromosome. All the cells created from the cells that have not lost the Y chromosome will be XY. The 46,XY cells will continue to multiply at the same time as the 45,X cells multiply.
Bare lymphocyte syndrome
Chronic granulomatous disease (Bridges–Good syndrome, chronic granulomatous disorder, Quie syndrome)
Common variable immunodeficiency (acquired hypogammaglobulinemia)
Complement deficiency
DiGeorge syndrome (DiGeorge anomaly, thymic hypoplasia)
Graft-versus-host disease
Griscelli syndrome
Hyper-IgE syndrome (Buckley syndrome, Job syndrome)
Immunodeficiency with hyper-IgM
Immunodeficiency–centromeric instability–facial anomalies syndrome (ICF syndrome)
Isolated IgA deficiency
Isolated primary IgM deficiency
Janus kinase 3 deficiency
Leukocyte adhesion molecule deficiency
LIG4 syndrome
Myeloperoxidase deficiency
Neutrophil immunodeficiency syndrome
Nezelof syndrome (thymic dysplasia with normal immunoglobulins)
Omenn syndrome 
Purine nucleoside phosphorylase deficiency
Severe combined immunodeficiency (alymphocytosis, Glanzmann–Riniker syndrome, severe mixed immunodeficiency syndrome, thymic alymphoplasia)
Shwachman–Bodian–Diamond syndrome
Thymoma with immunodeficiency (Good syndrome)
Transient hypogammaglobulinemia of infancy
Warts–hypogammaglobulinemia–infections–myelokathexis syndrome (WHIM syndrome)
Wiskott–Aldrich syndrome
X-linked agammaglobulinemia (Bruton syndrome, sex-linked agammaglobulinemia)
X-linked hyper-IgM syndrome
X-linked hypogammaglobulinemia
X-linked lymphoproliferative disease (Duncans disease)
X-linked neutropenia

Nutrition-related
Nutrition-related cutaneous conditions are caused by malnutrition due to an improper or inadequate diet. Biotin deficiency
Carotenemia
Essential fatty acid deficiency
Folic acid deficiency
Hypervitaminosis A
Hypovitaminosis A (phrynoderma)
Iron deficiency 
Kwashiorkor
Lycopenemia
Maple syrup urine disease
Marasmus
Niacin deficiency (pellagra, vitamin B3 deficiency)
Selenium deficiency
Vitamin B1 deficiency (beriberi, thiamine deficiency)
Vitamin B12 deficiency (cyanocobalamin deficiency)
Vitamin B2 deficiency (ariboflavinosis, riboflavin deficiency)
Vitamin B6 deficiency (pyridoxine deficiency)
Vitamin B6 excess (pyridoxine excess)
Vitamin C deficiency (scurvy)
Vitamin K deficiency
Zinc deficiency

Papulosquamous hyperkeratotic
Papulosquamous hyperkeratotic cutaneous conditions are those that present with papules and scales caused by a thickening of the stratum corneum.