Dyshidrosis is a type of dermatitis that is characterized by itchy blisters on the palms of the hands and bottoms of the feet. Blisters are generally one to two millimeters in size and heal over three weeks. However, they often recur. Redness is not usually present. Repeated attacks may result in fissures and skin thickening.The cause is unknown. Triggers may include allergens, physical or mental stress, frequent hand washing, or metals. Diagnosis is typically based on what it looks like and the symptoms. Allergy testing and culture may be done to rule out other problems. Other conditions that produce similar symptoms include pustular psoriasis and scabies.Avoiding triggers may be useful, as may a barrier cream. Treatment is generally with steroid cream. High strength steroid creams may be required for the first week or two. Antihistamines may be used to help with the itch. If this is not effective steroid pills, tacrolimus, or psoralen plus ultraviolet A (PUVA) may be tried.About 1 in 2,000 people are affected in Sweden. Males and females appear to be affected equally. It explains about one in five cases of hand dermatitis. The first description was in 1873. The name comes from the word "dyshidrotic", meaning "difficult sweating", as problems with sweating was once believed to be the cause. Signs and symptoms
Dyshidrosis has been described as having the following characteristics:

Itchiness of the palms or soles, followed by the sudden development of intensely itchy small blisters on the sides of the fingers, the palms or the feet.
Potassium permanganate dilute solution soaks – also popular, and used to dry out the vesicles, and kill off superficial Staphylococcus aureus, but it can also be very painful. Undiluted it may cause significant burning. Dapsone (diamino-diphenyl sulfone), an antibacterial, has been recommended for the treatment of dyshidrosis in some chronic cases. Antihistamines: Fexofenadine up to 180 mg per day. Alitretinoin (9-cis-retinoic acid) has been approved for prescription in the UK. It is specifically used for chronic hand and foot eczema. It is made by Basilea of Switzerland (BAL 4079). Systemic steroids can be taken orally to treat especially acute and severe cases of dyshidrosis. Epidemiology
About 1 in 2,000 people are affected in Sweden. Males and females appear to be affected equally. Synonyms
Dyshidrosis is also known as pompholyx, a term originating from the Greek word for "bubble". See also
Dermatitis herpetiformis – a similar condition caused by celiac and often mistaken for dyshidrosis. Epidermolysis bullosa – a genetic disorder that causes similar, albeit more severe, symptoms to those of dyshidrosis. References
External links

Images of dyshidrotic eczema at Skinsight
Pompholyx at DermNet NZ (New Zealand Dermatological Society Incorporated)