U.S. National Library of Medicine. "Sacituzumab govitecan". ADC Review. "Sacituzumab govitecan". National Cancer Institute. Clinical trial number NCT01631552 for "Phase I/II Study of IMMU-132 in Patients With Epithelial Cancers" at ClinicalTrials.gov
Clinical trial number NCT02574455 for "ASCENT-Study of Sacituzumab Govitecan in Refractory/Relapsed Triple-Negative Breast Cancer (ASCENT)" at ClinicalTrials.gov
Clinical trial number NCT03547973 for "Phase II Open Label, Study of IMMU-132 in Metastatic Urothelial Cancer" at ClinicalTrials.gov
Sacituzumab govitecan at the US National Library of Medicine Medical Subject Headings (MeSH)
Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning, including both short-term and long-term lead poisoning. Sodium calcium edetate came into medical use in the United States in 1953. Chelation agent
Sodium calcium edetate is in the chelating agent family of medication. It is a salt of edetate with two sodium and one calcium atoms. It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.Edetate disodium is a different formulation which does not have the same effects. Medical use
Sodium calcium edetates primary use is to treat lead poisoning,
for which it is an alternative to succimer. It is given by slow injection into a vein or into a muscle.For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol. It may also be used to treat plutonium poisoning. It does not appear to be useful for poisoning by tetra-ethyl lead. Side effects
Common side effects include pain at the site of injection. Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure. Benefits when needed in pregnancy are likely greater than the risks. History
Sodium calcium edetate came into medical use in the United States in 1953. It is on the World Health Organizations List of Essential Medicines. References
External links
"Sodium calcium edetate". U.S. National Library of Medicine. Drug Information Portal. U.S. National Institutes of Health.