Guaifenesin/phenylephrine is a combination of the drugs guaifenesin and phenylephrine and is a preparation against the symptoms of cold, flu and allergy. Guaifenesine is an expectorant, phenylephrine is a decongestant. The drug is sold under the brand name Entex and as generic brands. Entex La is 400 mg guaifenesin and 30 mg phenylephrine hydrochloride. Entex Pse is 600 mg guaifenesin and 120 mg phenylephrine hydrochloride. Both are extended release products, meaning that the non-active ingredients are chosen to dissolve slowly to provide a prolonged therapeutic effect. Guaifenesin
Guaifenesin is an oral medication used to try to help cough out phlegm from the airways. It is often used in combination with other medications. It is believed to work by making airway secretions more liquid. Side effects may include dizziness, sleepiness, skin rash, and nausea. Guaifenesin has been used medically since at least 1933. It is available as a generic medication and an over-the-counter drug. Phenylephrine

Phenylephrine is an oral medication primarily used as a decongestant. It is a selective α1-adrenergic receptor activator which results in the constriction of both arteries and veins. Common side effects include nausea, headache, and anxiety. Phenylephrine was patented in 1927 and came into medical use in 1938. It is available as a generic medication. == References ==
Richters syndrome (RS), also known as Richters transformation, is a transformation of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia into a fast-growing diffuse large B cell lymphoma, a variety of non-Hodgkin lymphoma which is refractory to treatment and carries a bad prognosis. There is also a less common variant in which the CLL changes into a Hodgkins lymphoma. Rarely, transformations to a form of myeloid leukemia have been observed. These extraordinarily rare transformations carry a very poor prognosis. Richters transformation affects about 5% of CLL patients at some point during their lives. Signs and symptoms
Symptoms of Richter’s transformation in a CLL patient include fever (without infection), elevated serum levels of lactate dehydrogenase, and rapidly enlarging lymph nodes. While about 8% of all CLL patients will have elevated levels of serum lactate dehydrogenase (LDH), more than 50% of CLL patients with Richters transformation will have elevated LDH levels.Richters can appear suddenly, even in patients who were in remission. Cause
A case of RS may have arisen by one of two different routes:  a transformation of the CLL cells into lymphoma, or the appearance of an unrelated lymphoma.It is thought that genetic defects may introduce the additional abnormalities necessary to transform CLL cells into Richters syndrome cells. Treatment
Treatment with conventional immunochemotherapy is usually indicated; in younger patients, allogeneic bone marrow transplantation may be curative. Prognosis
The prognosis is generally poor.