The term side effects is often applied to minor type A reactions.Type B: IdiosyncraticTypes A and B were proposed in the 1970s, and the other types were proposed subsequently when the first two proved insufficient to classify ADRs. Seriousness
The U.S Food and Drug Administration defines a serious adverse event as one when the patient outcome is one of the following:
Death
Life-threatening
Hospitalization (initial or prolonged)
Disability - significant, persistent, or permanent change, impairment, damage or disruption in the patients body function/structure, physical activities or quality of life. Congenital abnormality
Requires intervention to prevent permanent impairment or damageSeverity is a point on an arbitrary scale of intensity of the adverse event in question. The terms "severe" and "serious", when applied to adverse events, are technically very different. They are easily confused but can not be used interchangeably, requiring care in usage. A headache is severe if it causes intense pain. There are scales like "visual analog scale" that help clinicians assess the severity. On the other hand, a headache is not usually serious (but may be in case of subarachnoid haemorrhage, subdural bleed, even a migraine may temporally fit criteria), unless it also satisfies the criteria for seriousness listed above. Location
Adverse effects may be local, i.e. limited to a certain location, or systemic, where medication has caused adverse effects throughout the systemic circulation. For instance, some ocular antihypertensives cause systemic effects, although they are administered locally as eye drops, since a fraction escapes to the systemic circulation.
Simyra  is a genus of moths of the family Noctuidae. The genus was described by Ochsenheimer in 1816. Species
Simyra nervosa (Denis & Schiffermüller, 1775) central and southern Europe
Simyra albovenosa (Goeze, 1781) Europe, Turkey, northern Iran, Transcaucasia, Central Asia, southern Siberia
Simyra dentinosa Freyer, 1838 south-eastern Europe, Turkey, Caucasus, Transcaucasia, Lebanon, Syria, Israel, Egypt, Iran
Simyra albicosta Hampson, 1909 Nilgiri Mountains of India
Simyra capillata Wallengren, 1875 South Africa
Simyra confusa (Walker, 1856) Sri Lanka, Arabia
Simyra conspersa Moore, 1881 Punjab, Sikkim, Bengal
Simyra renimaculata (Osthelder, 1932) Turkey
Simyra saepestriata (Alphéraky, 1895) Japan, Korea, Mongolia
Simyra sincera Warren, 1914
Simyra splendida Staudinger, 1888 Turkestan, Tibet, southern Siberia, Korea
Simyra insularis (Herrich-Schäffer, 1868) Ontario, New York, Massachusetts, Kansas, California, New Mexico, Cuba
Simyra unifacta Dyar, 1912 Mexico


== References ==