The attacks of cataplexy in dogs can involve partial or full collapse. Narcolepsy with cataplexy was identified in a few breeds like Labrador retrievers or Doberman pinschers where it was investigated the possibility to inherit this disorder in the autosomal recessive mode. According to  a reliable canine model for narcolepsy would be the one in which the narcoleptic symptoms are the result of a mutation in the gene HCRT 2. The animals affected exhibited excessive daytime sleepiness with a reduced state of vigilance and severe cataplexy resulted after palatable food and interactions with the owners or with other animals. Rodent models
Mice that are genetically engineered to lack orexin genes demonstrate many similarities to human narcolepsy. During nocturnal hours, when mice are normally present, those lacking orexin demonstrated murine cataplexy and displayed brain and muscle electrical activity similar to the activity present during REM and NREM sleep. This cataplexy is able to be triggered through social interaction, wheel running, and ultrasonic vocalizations. Upon awakening, the mice also display behavior consistent with excessive daytime sleepiness.Mice models have also been used to test whether the lack of orexin neurons is correlated with narcolepsy. Mice whose orexin neurons have been ablated have shown sleep fragmentation, SOREMPs, and obesity.Rat models have been used to demonstrate the association between orexin deficiency and narcoleptic symptoms. Rats who lost the majority of their orexinergic neurons exhibited multiple SOREMPs as well as less wakefulness during nocturnal hours, shortened REM latency, and brief periods of cataplexy. References
External links

"Narcolepsy Information Page".
Genital pain and pelvic pain can arise from a variety of conditions, crimes, trauma, medical treatments, physical diseases, mental illness and infections. In some instances the pain is consensual and self-induced. Self-induced pain can be a cause for concern and may require a psychiatric evaluation. In other instances the infliction of pain is consensual but caused by another person (such as in surgery or tattooing). In other instances, the pain is vague" and difficult to localize. Abdominal pain can be related to conditions related to reproductive and urinary tissues and organs. Those with pain in the genital and pelvic regions can have dysfunctional voiding or defecation. Pain in this region of the body can be associated with anxiety, depression and other psycho-social factors. In addition, this pain can have effects on activities of daily living or quality of life. Treatment can be symptomatic if the pathology is unknown and managed by physical therapy, counseling and medication. Common to women and men
Females
Males
Children
child abuse
dermatitis
imperforate hymen
pinworms

Treatments
Analgesic
Cordotomy
Medical lubricant
Personal lubricant


== References ==