Flood risk management
Analysis of flood information
A series of annual maximum flow rates in a stream reach can be analyzed statistically to estimate the 100-year flood and floods of other recurrence intervals there. Similar estimates from many sites in a hydrologically similar region can be related to measurable characteristics of each drainage basin to allow indirect estimation of flood recurrence intervals for stream reaches without sufficient data for direct analysis. Physical process models of channel reaches are generally well understood and will calculate the depth and area of inundation for given channel conditions and a specified flow rate, such as for use in floodplain mapping and flood insurance. Conversely, given the observed inundation area of a recent flood and the channel conditions, a model can calculate the flow rate. Applied to various potential channel configurations and flow rates, a reach model can contribute to selecting an optimum design for a modified channel. Various reach models are available as of 2015, either 1D models (flood levels measured in the channel) or 2D models (variable flood depths measured across the extent of a floodplain). HEC-RAS, the Hydraulic Engineering Center model, is among the most popular software, if only because it is available free of charge. Other models such as TUFLOW combine 1D and 2D components to derive flood depths across both river channels and the entire floodplain. Physical process models of complete drainage basins are even more complex.
Along with estradiol valerate (1954) and estradiol benzoate (1933), estradiol cypionate has become one of the most commonly used esters of estradiol.When estradiol cypionate was to be combined with medroxyprogesterone acetate as a once-a-month injectable contraceptive, there was a problem in that estradiol cypionate was prepared as an oil solution while medroxyprogesterone acetate was used as a microcrystalline aqueous suspension. This issue was resolved by switching to a microcrystalline aqueous suspension in the case of estradiol cypionate, allowing it to be combined with medroxyprogesterone acetate in a single suspension. As a result, single-drug preparations of estradiol cypionate are oil solutions, while the combination of estradiol cypionate and medroxyprogesterone acetate are microcrystalline aqueous suspensions. Society and culture
Generic names
Estradiol cypionate is the generic name of the drug and its INN and USAN. It is also known as estradiol cyclopentylpropionate (ECP). Brand names
Estradiol cypionate has been marketed under the brand names Cicloestradiolo, D-Est, depGynogen, Depo-Estradiol, Depoestra, Depofemin, Depogen, Dura-Estrin, E-Cypionate, E-Ionate, Estradep, Estro-Cyp, Estrofem, Estroject, Estromed-PA, Estronol, Femovirin, Neoginon Depositum, Oestradiol-Retard, Pertradiol, Spendepiol, and T-E Cypionate, among others. Availability
Estradiol cypionate is available in the United States. It was previously marketed in Spain and Italy, but was discontinued in these countries and is no longer available in Europe. Estradiol cypionate has mostly been used in the United States, similarly to testosterone cypionate, with both of these medications having been developed by Upjohn, an American pharmaceutical company. Besides the United States, estradiol cypionate has been marketed in France, Germany, Italy, Spain, and Japan, among other countries.