In Zimbabwe and Nepals Annapurna region, where underdevelopment is taking place, more than 90 percent of ecotourism revenues are expatriated to the parent countries, and less than 5 percent go into local communities.The lack of sustainability highlights the need for small scale, slow growth, and locally based ecotourism. Local peoples have a vested interest in the well-being of their community, and are therefore more accountable to environmental protection than multinational corporations, though they receive very little of the profits. The lack of control, westernization, adverse impacts to the environment, loss of culture and traditions outweigh the benefits of establishing large scale ecotourism. Additionally, culture loss can be attributed to cultural commodification, in which local cultures are commodified in order to make a profit.The increased contributions of communities to locally managed ecotourism create viable economic opportunities, including high-level management positions, and reduce environmental issues associated with poverty and unemployment. Because the ecotourism experience is marketed to a different lifestyle from large scale ecotourism, the development of facilities and infrastructure does not need to conform to corporate Western tourism standards, and can be much simpler and less expensive. There is a greater multiplier effect on the economy, because local products, materials, and labor are used. Profits accrue locally and import leakages are reduced. The Great Barrier Reef Park in Australia reported over half of a billion dollars of indirect income in the area and added thousands of indirect jobs between 2004 and 2005. However, even this form of tourism may require foreign investment for promotion or start-up.
Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M1 and M3 receptors. It is used in the treatment of dry mouth and Sjögrens syndrome. Medical uses
Cevimeline is used in the treatment of xerostomia (dry mouth), and Sjögrens syndrome. It increases the production of saliva. Side effects
Known side effects include nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, and difficulty sleeping.Contraindications include asthma and angle closure glaucoma. Mechanism of action
Cevimeline is a cholinergic agonist. It has a particular effect on M1 and M3 receptors. By activating the M3 receptors of the parasympathetic nervous system, cevimeline stimulates secretion by the salivary glands, thereby alleviating dry mouth. See also
Pilocarpine — a similar parasympathomimetic medication for dry mouth (xerostomia)
Bethanechol — a similar muscarinic parasympathomimetic with longer-lasting effect

References
External links
Evoxac (cevimeline HCl hydrate capsules) Full Prescribing Information