An accumulation of fluid results and the joints swell, slowly decreasing the space that keeps the bones from touching. If this condition is not treated, the joint space will completely narrow, causing ankylosis. At the advanced stage of ankylosis, joint mobility is completely occluded. Early presentation is commonly seen in the joints of hands and of the feet. As the disease progresses it can be seen in the knees, wrists, hips, and shoulders. This condition can affect and damage several other body systems such as the eyes, heart, lungs, and blood vessels.Rheumatoid arthritis is a condition that cannot be cured but symptoms can be treated using certain medications alone or in conjunction. Due to the increased inflammatory response of the bodys immune system, this condition can cause a reduction in red and white blood cells. Neutropenia
In Feltys syndrome, chronic activation of neutrophils progresses to neutropenia and unabated infections. Neutropenia is a decreased concentration of neutrophils in the blood. Neutrophils are the most abundant cells among white blood cells and play an important role in the immune system by destroying bacteria via phagocytosis. Inflammatory chemicals draw neutrophils to the area where they congregate and fight infection. A decrease in the number of neutrophils stimulates an autoimmune response which leads to arthritis. The loss and destruction of neutrophils leading to neutropenia are, therefore, inflammation-driven due to the bodys need for an immune response. Splenomegaly
Splenomegaly is a condition of the spleen causing it to be enlarged. The splenic condition involving Felty syndrome is more specifically noted as inflammatory splenomegaly.
[3]

Epidemiology
Transient neonatal pustular melanosis occurs in as much as 15% of black newborns. [3] but in less than 1% of white newborns. [2]

See also
List of cutaneous conditions

References

1. OConnor NR, McLaughlin, MR, Ham P (2008). "Newborn Skin: Part I. Common Newborn Rashes". American Family Physician. 77 (1): 47–52. 2. Patrizi A, Neri I, Virid A, Gurioli C.(2016). "Frequent newborn skin diseases". Clinical Dermatology. 4 (3-4): 82–86. doi: 10.11138/cderm/2016.4.3.082. 3. Ghosh S. (2015). "Neonatal Pustular Dermatosis: An Overview". Indian Journal of Dermatology. 60 (2): 211. doi: 10.4103/0019-5154.152558
4. Ferrándiz C, Coroleu W, Ribera M, Lorenzo JC, Natal A (1992). "Sterile transient neonatal pustulosis is a precocious form of erythema toxicum neonatorum". Dermatology. 185:18–22. 5. Mebazaa A, Khaddar-Kort R, Cherif M, Mokni S, Haouet A, Osman B (2011). "Transient pustular eruption in neonates". Archives de Pediatrie. 18 (3) 291–293.