Ischemia or ischaemia is a restriction in blood supply to any tissues, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue i.e. hypoxia and microvascular dysfunction. It also means local hypoxia in a given part of a body sometimes resulting from constriction (such as vasoconstriction, thrombosis or embolism). Ischemia comprises not only insufficiency of oxygen, but also reduced availability of nutrients and inadequate removal of metabolic wastes. Ischemia can be partial (poor perfusion) or total blockage. The inadequate delivery of oxygenated blood to the organs must be resolved either by treating the cause of the inadequate delivery or reducing the oxygen demand of the system that needs it. For example, patients with myocardial ischemia have a decreased blood flow to the heart and are prescribed with medications that reduce chronotrophy and ionotrophy to meet the new level of blood delivery supplied by the stenosed so that it is adequate. Signs and symptoms
The signs and symptoms of ischemia vary, as it can occur anywhere in the body and depends on the degree to which blood flow is interrupted. For example, clinical manifestations of acute limb ischemia (which can be summarized as the "six Ps") include pain, pallor, pulseless, paresthesia, paralysis, and poikilothermia.Without immediate intervention, ischemia may progress quickly to tissue necrosis and gangrene within a few hours.
An ulcer is a discontinuity or break in a bodily membrane that impedes normal function of the affected organ. According to Robbinss pathology, "ulcer is the breach of the continuity of skin, epithelium or mucous membrane caused by sloughing out of inflamed necrotic tissue." Common forms of ulcers recognized in medicine include:
Ulcer (dermatology), a discontinuity of the skin or a break in the skin. Pressure ulcers, also known as bedsores
Genital ulcer, an ulcer located on the genital area
Ulcerative dermatitis, a skin disorder associated with bacterial growth often initiated by self-trauma
Anal fissure, a.k.a. an ulcer or tear near the anus or within the rectum
Diabetic foot ulcer, a major complication of the diabetic foot
Corneal ulcer, an inflammatory or infective condition of the cornea
Mouth ulcer, an open sore inside the mouth. Aphthous ulcer, a specific type of oral ulcer also known as a canker sore
Peptic ulcer, a discontinuity of the gastrointestinal mucosa (stomach ulcer)
Venous ulcer, a wound thought to occur due to improper functioning of valves in the veins
Stress ulcer, an ulcer located  within the stomach and proximal duodenum
Ulcerative sarcoidosis, a cutaneous condition affecting people with sarcoidosis
Ulcerative lichen planus, a rare variant of lichen planus
Ulcerative colitis, a form of inflammatory bowel disease (IBD). Ulcerative disposition, a disorder or discomfort that causes severe abdominal distress, often associated with chronic gastritis

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