Fosfomycin is a PEP analog that inhibits MurA by alkylating an active site cysteine residue (Cys 115 in the Escherichia coli enzyme).Fosfomycin enters the bacterial cell through the glycerophosphate transporter. History
Fosfomycin (originally known as phosphonomycin) was discovered in a joint effort of Merck and Co. and Spains Compañía Española de Penicilina y Antibióticos (CEPA). It was first isolated by screening broth cultures of Streptomyces fradiae isolated from soil samples for the ability to cause formation of spheroplasts by growing bacteria. The discovery was described in a series of papers published in 1969. CEPA began producing fosfomycin on an industrial scale in 1971 at its Aranjuez facility. Manufacture
The complete fosfomycin biosynthetic gene cluster from Streptomyces fradiae has been cloned and sequenced and the heterologous production of fosfomycin in S. lividans has been achieved by Ryan Woodyer of the Huimin Zhao and Wilfred van der Donk research groups.Large scale production of fosfomycin is achieved by making an epoxide of cis-propenylphosphonic acid to yield racemic mixture fosfomycin. References
External links
"Fosfomycin". Drug Information Portal. U.S. National Library of Medicine.
Lichen aureus  is a skin condition characterized by the sudden appearance of one or several golden or rust-colored, closely packed macules or lichenoid papules. : 830

See also
Pigmentary purpuric eruptions
List of cutaneous conditions

References


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