Presence of reactive oxygen species (ROS), can induce irreversible structural damage and alter protein activities. Loss via kidneys
In the healthy kidney, albumins size and negative electric charge exclude it from excretion in the glomerulus. This is not always the case, as in some diseases including diabetic nephropathy, which can sometimes be a complication of uncontrolled or of longer term diabetes  in which proteins can cross the glomerulus. The lost albumin can be detected by a simple urine test. Depending on the amount of albumin lost, a patient may have normal renal function, microalbuminuria, or albuminuria. Interactions
Human serum albumin has been shown to interact with FCGRT.It might also interact with a yet-unidentified albondin (gp60), a certain pair of gp18/gp30, and some other proteins like osteonectin, hnRNPs, calreticulin, cubilin, and megalin. See also
Bovine serum albumin
Serum albumin

References
Further reading
External links
Human Albumin structure in the Protein data bank
Human Serum Albumin on the Human Protein Reference Database
Albumin binding prediction
Albumin at Lab Tests Online
Albumin: analyte monograph from the Association for Clinical Biochemistry and Laboratory Medicine
Overview of all the structural information available in the PDB for UniProt: P02768 (Serum albumin) at the PDBe-KB.
LACIs are strongly associated with the development of white matter lesions (WML) which can be detected via the use of computerized tomography (CT scans). Risk factors
There are various individual risk factors associated with having a silent stroke. Many of these risk factors are the same as those associated with having a major symptomatic stroke. Acrolein: elevated levels of acrolein, a toxic metabolite produced from the polyamines spermine, spermidine and by amine oxidase serve as a marker for silent stroke, when elevated in conjunction with C-reactive protein and interleukin 6 the confidence levels in predicting a silent stroke risk increase. Adiponectin: is a type of protein secreted by adipose cells that improves insulin sensitivity and possesses antiatherogenic properties. Lower levels of s-adiponectin are associated with ischemic stroke. Aging: the prevalence of silent stroke rises with increasing age with a prevalence rate of over twenty percent of the elderly increasing to 30%-40% in those over the age of 70. Anemia: children with acute anemia caused by medical conditions other than sickle cell anemia  with hemoglobin below 5.5 g/dL. are at increased risk for having a silent stroke according to a study released at American Stroke Associations International Stroke Conference 2011. The researchers suggested a thorough examination for evidence of silent stroke in all severely anemic children in order to facilitate timely intervention to ameliorate the potential brain damage.Sickle cell anemia: is an autosomal recessive genetic blood disorder caused in the gene (HBB gene) which codes for hemoglobin (Hg) and results in lowered levels.