Splenic lymphoma with villous lymphocytes is a rare type of lymphoma that involves mature B cells. Older names include  lymphoma simulating hairy cell leukemia and lymphoplasmacytic lymphoma with circulating villous lymphocytes. The characteristic villous lymphocytes will appear in a blood smear of the peripheral blood of patients with this type of lymphoma. These lymphocytes will have an oval nucleus with the “cobblestone” pattern of nuclear chromatin typical of more mature lymphoid cells. The cytoplasmic projections, or villi, are found in a polar distribution. Whether this condition is identical to splenic marginal zone lymphoma, or only highly similar, is a matter of debate. == References ==
Causes
This condition is caused due to incomplete fusion of both sides of the nose during embryonic life.This anomaly is highly hereditary: autosomal dominant and autosomal recessive inheritance patterns have been observed in multiple families.If the bifid nose is accompanied by abnormalities of the anorectal and renal systems, it may be part of a different separate genetic disorder (which is characterized by overlapping toes, renal adysplasia and variable anorectal anomalies) that is caused by autosomal recessive mutations in the FREM1 gene. Treatment
Generally, sutures and rhinoplasty can be done in order to get rid of a bifid nose tip (though what surgery should be done depends on the severity of the cleft nose). Open W-shaped surgical incisions have also proven to be effective. Surgery is usually done before the age of 5. Prevalence
This birth anomaly affects less than 0.0008% of people worldwide, making it the most common midline craniofacial cleft.8% of people with bifid nose also have hypertelorism. Bifid nose as a hereditary trait
Two forms of inheritance pattern for bifid noses have been described: autosomal recessive and autosomal dominant. One case per inheritance pattern follows:

Autosomal dominant: Anyane-Yeboa et al. (1984) describes 5 women from a 3-generation American family. Karyotypes and skull X-rays done on the younger sisters gave normal results. Autosomal recessive: Boo-Chai et al. (1965) describes 3 siblings from a continental Indian family. History
This condition was first described in medical literature in 1939 by Esser et al. when they described 5 children (4 siblings and a male first-cousin of theirs) from a single family.