A full endoscopic examination of the larynx, trachea, and esophagus is often performed at the time of biopsy.For small glottic tumours further imaging may be unnecessary. In most cases, tumour staging is completed by scanning the head and neck region to assess the local extent of the tumour and any pathologically enlarged cervical lymph nodes. The final management plan will depend on the site, stage (tumour size, nodal spread, distant metastasis), and histological type. The overall health and wishes of the patient must also be taken into account. A prognostic multigene classifier has been shown to be potentially useful for the distinction of laryngeal cancer of low or high risk of recurrence and might influence the treatment choice in future. Staging
Laryngeal tumours are classified according to the guidelines set by academic organisations such as the National Comprehensive Cancer Network (NCCN) . Overall classification, also known as "staging", can help predict treatment options for patients. Staging consists of three separate evaluations. The first is of the tumour/cancer itself ("T"). The second is the extent to which adjacent lymph nodes are involved in the tumour/cancers spread ("N"). The third is the presence or absence of any distant metastases ("M). The specific “staging” criteria for laryngeal cancer, as utilised in the NCCN’s 2019 Guidelines for Head and Neck Cancers, are:

T
TX: Unable to assess
Tis: Carcinoma in situ

Supraglottis
T1: Tumour present in only one subsite of the supraglottis. Vocal cords have normal mobility. T2: Tumour invades mucosa. There is no fixation of the larynx.
Treatment may involve surgery, radiotherapy, or chemotherapy, alone or in combination.Surgical Treatment
Surgical treatment may involve partial or full removal of the tumour. Neighbouring tissues and structures may or may not be removed, depending on their involvement in the tumour’s structure and spread. Full removal of the larynx may be necessary in some cases. Adjunct Treatment
Adjunct treatment, most commonly the administration of chemotherapy or radiotherapy, may be necessary. Chemotherapy or radiotherapy may be necessary singly, in combination with each other, or in combination with surgery. Adjunct treatment may be necessary prior to surgical treatment, alongside surgical treatment, or after surgical treatment. Clinical decision-making can be difficult in circumstances where the patient is unable to access necessary adjunct treatment. Multi-Disciplinary Treatment
Often, successful treatment of and recovery from laryngeal cancer will involve expertise outside of the realms of surgery or oncology. Physical therapists, occupational therapists, speech therapists, psychiatrists, psychologists, oral/maxillofacial surgeons,  dentists, neurologists, neurosurgeons, and endocrinologists may all become involved in the care of patients with laryngeal cancer. Epidemiology
Incidence is five in 100,000 (12,500 new cases per year) in the US. The American Cancer Society estimated that 9,510 men and women (7,700 men and 1,810 women) would be diagnosed with and 3,740 men and women would die of laryngeal cancer in 2006.According to the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, there were 177,422 new cases of laryngeal cancer worldwide in 2018 (1.0% of the global total.) Among worldwide cancer deaths, 94,771 (1.0%) were due to laryngeal cancer.