When desmogleins are attacked, skin cells separate from each other and fluid can collect between the layers of skin, forming blisters that do not heal. In some cases, these blisters can cover a large area of skin. Diagnosis
Pemphigus foliaceus is diagnosed base on history, biopsy of the affected skin, and testing either a blood sample or a skin sample for the antibodies that cause pemphigus. Treatment
Epidemiology
Pemphigus is endemic in the rural areas of Brazil, especially along inland riverbeds. History
Pierre Louis Alphée Cazenave first described the disease in 1844. See also
List of cutaneous conditions
Pemphigus

References


== External links ==
As for safety, the IOM sets Tolerable upper intake levels (ULs) for vitamins and minerals when evidence is sufficient. In the case of fluoride the UL is 10 mg/day. Collectively the EARs, RDAs, AIs and ULs are referred to as Dietary Reference Intakes (DRIs).The European Food Safety Authority (EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA, and Average Requirement instead of EAR. AI and UL defined the same as in United States. For women ages 18 and older the AI is set at 2.9 mg/day (includes pregnancy and lactation). For men the value is 3.4 mg/day. For children ages 1–17 years the AIs increase with age from 0.6 to 3.2 mg/day. These AIs are comparable to the U.S. AIs. The EFSA reviewed safety evidence and set an adult UL at 7.0 mg/day (lower for children). See also
Water fluoridation
Public relations campaigns of Edward Bernays

References


== External links ==