Chromosome 14 is also known to cause particular symptoms such as skeletal abnormalities, intellectual disability, and joint contractures, among others.UPD has rarely been studied prospectively, with most reports focusing on either known conditions or incidental findings. It has been proposed that the incidence may not be as low as believed, rather it may be under-reported. All chromosomes
Genome wide UPD, also called uniparental diploidy, is when all chromosomes are inherited from one parent. Only in mosaic form can this phenomenon be compatible with life. As of 2017, there have only been 18 reported cases of genome wide UPD. History
The first clinical case of UPD was reported in 1988 and involved a girl with cystic fibrosis and short stature who carried two copies of maternal chromosome 7. Since 1991, out of the 47 possible disomies, 29 have been identified among individuals ascertained for medical reasons. This includes chromosomes 2, 5–11, 13–16, 21 and 22. See also
Aneuploidy

References
External links

"Uniparental disomy". Department of Medical Genetics, University of British Columbia. Archived from the original on 2002-06-17. {{cite web}}:  CS1 maint: unfit URL (link)
T. Liehr: Cases with uniparental disomy
UPD Animations: UPD AnimationsThis article incorporates public domain text from The U.S. National Library of Medicine
Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of severe acne vulgaris. It consists of a combination of adapalene and benzoyl peroxide in a topical gel formulation. Medical uses
Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris. Side effects
Commonly reported side effects include the following:
Skin redness
Scaling
Dry skin
Contact dermatitis
Skin irritation
Stinging
Burning

Research
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002). References
External links
"Adapalene mixture with benzoyl peroxide". Drug Information Portal. U.S. National Library of Medicine.