Multifocal fibrosclerosis and idiopathic fibrosclerosis are disorders of unknown aetiology, characterised by fibrous lesions (co-)occurring at a variety of sites. Known manifestations include retroperitoneal fibrosis, mediastinal fibrosis and Riedels thyroiditis.They are now considered to be manifestations of IgG4-related disease. References


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Braak stages I and II are used when NFT involvement is confined mainly to the transentorhinal region of the brain, stages III and IV when theres also involvement of limbic regions such as the hippocampus, and V and VI when theres extensive neocortical involvement. This should not be confused with the degree of senile plaque involvement, which progresses differently. Other diseases
Primary age-related tauopathy (PART) dementia, with NFTs similar to AD, but without amyloid plaques. Chronic traumatic encephalopathy (CTE)
Progressive supranuclear palsy (PSP)
Corticobasal degeneration (CBD)
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
Vacuolar tauopathy
Lytico-bodig disease (Parkinson-dementia complex of Guam)
Ganglioglioma and gangliocytoma
Meningioangiomatosis
Postencephalitic parkinsonism
Subacute sclerosing panencephalitis (SSPE)
As well as lead encephalopathy, tuberous sclerosis, Pantothenate kinase-associated neurodegeneration, and lipofuscinosisIn both Picks disease and corticobasal degeneration, tau proteins are deposited as inclusion bodies within swollen or "ballooned" neurons.Argyrophilic grain disease (AGD), another type of dementia, is marked by an abundance of argyrophilic grains and coiled bodies upon microscopic examination of brain tissue. Some consider it to be a type of Alzheimers disease. It may co-exist with other tauopathies such as progressive supranuclear palsy and corticobasal degeneration, and also Picks disease.Tauopathies are often overlapped with synucleinopathies, possibly due to interaction between the synuclein and tau proteins.The non-Alzheimers tauopathies are sometimes grouped together as "Picks complex" due to their association with frontotemporal dementia, or frontotemporal lobar degeneration. See also
Proteopathy

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