Since optimal contact between B cells and T cells is required (via MHC II) to maximize antibody production, it is reasoned that the conjugate vaccine allows B cells to properly recruit T cells, this is in contrast to the polysaccharide form in which it is speculated that B cells do not interact optimally with T cells leading to the TI interaction. Developing world
Introduction of Hib vaccine in developing countries lagged behind that in developed countries for several reasons. The expense of the vaccine was large in comparison to the standard EPI vaccines. Poor disease surveillance systems and inadequate hospital laboratories failed to detect the disease, leading many experts to believe that Hib did not exist in their countries. And health systems in many countries were struggling with the current vaccines they were trying to deliver. GAVI and the Hib Initiative
In order to remedy these issues, the GAVI Alliance took active interest in the vaccine. GAVI offers substantial subsidization of Hib vaccine for countries interested in using the vaccine, as well as financial support for vaccine systems and safe injections. In addition, GAVI created the Hib Initiative to catalyze uptake of the vaccine. The Hib Initiative uses a combination of collecting and disseminating existing data, research, and advocacy to assist countries in the making a decision about using the Hib vaccine. Currently, 61 out of 72 low-income countries are planning on introducing the vaccine by the end of 2009.
The effect of ephedrine is delayed and the improvement occurs over a period of months.Salbutamol, a selective β(2)-adrenergic receptor agonist, has been found, in adults, to have fewer side effects than Ephedrine and to be more easily obtained in some countries. It has been trialed in children with positive resultsAs of 2022, the standard of care for DOK7  CMS is either ephedrine or salbutamol. People
Two brothers with apparent myasthenic syndrome with a seemingly circadian off/on cycle, living near Quetta, Pakistan were nicknamed the solar kids, because their condition resulted in an inability to move from approximately sunset to sunrise, while their daytime motor abilities were seemingly normal. Doctors observed that some "factor" seemed to become exhausted in the course of normal diurnal activities, and was "recharged" over the period of inertia and sleep. The father first sought help from spiritual healers, then turned to Western medicine. A younger brother of the two had also begun to manifest the same symptoms. The family had other children, two daughters and one son, who were unaffected. The "solar kids" condition, despite extensive testing, was said to be undiagnosed as of 2016, and assumed to be genetic, as their parents were cousins. Samples of their genetic material were to be sent to the UK for analysis. See also
Congenital disorder
Myasthenia gravis
Lambert-Eaton syndrome

References
External links
Congenital Myasthenic Syndromes
About Congenital Myasthenic Syndrome From the Mayo Clinic
Treatment for Congenital Myasthenic Syndromes From the Mayo Clinic