Malignant infantile osteopetrosis is known for exhibiting specific plain radiographic abnormalities:
Loss of differentiation between the medullary and cortical portions of bone is a radiographic hallmark of infantile osteopetrosis
Characteristic endobone or "bone-within-bone" appearance in the spine, or "sandwich vertebra" appearance, characterized by dense endplate sclerosis with sharp margins
Characteristic endobone or "bone-within-bone" appearance in the pelvis and  long bones of extremities where areas of osteosclerosis intermingle with areas of relatively hypodense bone. Failure of remodeling of the distal femoral and proximal humeral metaphyses giving the affected bones a funnel shaped appearance known as an Erlenmeyer flask deformity
Alternating radiolucent femoral metaphyseal bands
Pathologic fractures

Differential diagnosis
The differential diagnosis of malignant infantile osteopetrosis includes other genetic skeletal dysplasias that cause osteosclerosis. They are collectively known as osteosclerosing dysplasias. The differential diagnosis of genetic osteosclerosing dysplasias including infantile osteopetrosis has been tabulated and illustrated in literature citations. Neuropathic infantile osteopetrosis
Infantile osteopetrosis with renal tubular acidosis
Infantile osteopetrosis with immunodeficiency
IO with leukocyte adhesion deficiency syndrome (LAD-III)
Intermediate osteopetrosis
Autosomal dominant osteopetrosis (Albers-Schonberg)
Pyknodysostosis (osteopetrosis acro-osteolytica)
Osteopoikilosis (Buschke–Ollendorff syndrome)
Osteopathia striata with cranial sclerosis
Mixed sclerosing bone dysplasia
Progressive diaphyseal dysplasia (Camurati–Engelmann disease)
SOST-related sclerosing bone dysplasias

Treatment
The only effective line of treatment for malignant infantile osteopetrosis is hematopoietic stem cell transplantation. It has been shown to provide long-term disease-free periods for a significant percentage of those treated. It can impact both hematologic and skeletal abnormalities; and has been used successfully to reverse the associated skeletal abnormalities.Radiographs of at least one case with malignant infantile osteopetrosis have demonstrated bone remodeling and recanalization of medullar canals following hematopoietic stem cell transplantation.
The condition appears to be genetically determined and caused by the presence in the nose of erectile tissue which may become engorged during sexual arousal, as a side effect of the signals from the autonomic nervous system that trigger changes in the genitals of both men and women. A related condition called sexually induced sneezing also exists, where people sneeze, sometimes uncontrollably, when engaging in or even thinking about sexual activity. A phenomenon presumably related to honeymoon rhinitis is the frequent side effect of nasal congestion during the use of Viagra or related phosphodiesterase type 5 antagonists. Gustatory rhinitis – spicy and pungent food may in some people produce rhinorrhea, nasal stuffiness, lacrimation, sweating and flushing of face. It can be relieved by ipratropium bromide nasal spray (an anticholinergic), a few minutes before a meal. Non-air flow rhinitis – it is seen in patients of laryngectomy, tracheostomy and choanal atresia. Nose is not used for air flow and the turbinates become swollen due to loss of vasomotor control. In choanal atresia there is an additional factor of infection due to stagnation of discharge in the nasal cavity which should otherwise drain freely into nasopharynx. Photic sneeze reflex is a reflex condition that causes sneezing in response to looking at bright lights. Presentation
Paroxysmal sneezing in morning, especially in morning while getting out of bed. Excessive rhinorrhea – watering discharge from the nose when patient bends forward.