Contraindications
Use of diazepam should be avoided, when possible, in individuals with:
Ataxia
Severe hypoventilation
Acute narrow-angle glaucoma
Severe hepatic deficiencies (hepatitis and liver cirrhosis decrease elimination by a factor of two)
Severe renal deficiencies (for example, patients on dialysis)
Liver disorders
Severe sleep apnea
Severe depression, particularly when accompanied by suicidal tendencies
Psychosis
Pregnancy or breast feeding
Caution required in elderly or debilitated patients
Coma or shock
Abrupt discontinuation of therapy
Acute intoxication with alcohol, narcotics, or other psychoactive substances (with the exception of hallucinogens or some stimulants, where it is occasionally used as a treatment for overdose)
History of alcohol or drug dependence
Myasthenia gravis, an autoimmune disorder causing marked fatiguability
Hypersensitivity or allergy to any drug in the benzodiazepine class

Caution
Benzodiazepine abuse and misuse should be guarded against when prescribed to those with alcohol or drug dependencies or who have psychiatric disorders. Pediatric patients
Less than 18 years of age, this treatment is usually not indicated, except for treatment of epilepsy, and pre- or postoperative treatment. The smallest possible effective dose should be used for this group of patients. Under 6 months of age, safety and effectiveness have not been established; diazepam should not be given to those in this age group. Elderly and very ill patients can possibly experience apnea or cardiac arrest. Concomitant use of other central nervous system depressants increases this risk. The smallest possible effective dose should be used for this group of people. The elderly metabolise benzodiazepines much more slowly than younger adults, and are also more sensitive to the effects of benzodiazepines, even at similar blood plasma levels.
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