Both of these techniques are difficult to apply to polyglutamine diseases because targeting the polyglutamine tract may cause normal genes to be downregulated as well. SCA1 has also shown to be difficult to target reliably with single-nucleotide polymorphisms limiting the number of ways RNAi and antisense therapy techniques can be designed to treat SCA1. Reducing toxicity and increasing cell survival
Because of the numerous interactions ataxin-1 has with other proteins, techniques for reducing toxicity of the mutant ataxin-1 protein often change the expression of related proteins. For example, ataxin-1-like has many common domains with ataxin-1 and overexpression of ataxin-1-like compete with ataxin-1 and prevent its integration into other complexes, reducing toxicity. This effect was replicated in mice models using AAVs, and shown to be about as effective as RNAi techniques at slowing the progression of symptoms. Similarly, the drug baclofen, which is used to help reduce spasticity in persons with multiple sclerosis and related diseases, operates as an agonist of γ-aminobutyric acid type B receptors (GABABR). This pathway crosstalks with the mGluR1 pathway, which interacts with the ataxin 1 protein and proteins responsible for localization and degradation of ataxin 1, suggesting that baclofen may be a viable treatment for SCA 1 treatment.Molecular chaperones are introduced proteins that may have interactions with the mutant protein that reduce toxicity by various mechanisms.
RID may refer to:

Isaiah ben Mali di Trani (the Elder), an Italian Talmudist
Radial immunodiffusion, a scientific technique for measuring the quantity of an antigen
Radionuclide identification device, a hand-held instrument for the detection and identification of radioactive sources
Refractive index detector, a type of chromatography detector
Registry of Interpreters for the Deaf, an American Sign Language interpreters organization
Relative identifier, a component of Microsoft Windows NT security
RID (insect repellent), an Australian brand
Rivista Italiana Difesa, an Italian magazine related to military and geo-strategic issues
Robots in Disguise, an English electro band
Royal Institute Dictionary, a prescriptive dictionary of Thailand
Real-time Inter-network Defense, a reporting method for sharing incident-handling data between networks