Metaphorical uses
The word "blind" (adjective and verb) is often used to signify a lack of knowledge of something. For example, a blind date is a date in which the people involved have not previously met; a blind experiment is one in which information is kept from either the experimenter or the participant to mitigate the placebo effect or observer bias. The expression "blind leading the blind" refers to incapable people leading other incapable people. Being blind to something means not understanding or being aware of it. A "blind spot" is an area where someone cannot see: for example, where a car driver cannot see because parts of his cars bodywork are in the way; metaphorically, a topic on which an individual is unaware of their own biases, and therefore of the resulting distortions of their own judgements (see Bias blind spot). Research
A 2008 study tested the effect of using gene therapy to help restore the sight of patients with a rare form of inherited blindness, known as Lebers congenital amaurosis or LCA. Lebers Congenital Amaurosis damages the light receptors in the retina and usually begins affecting sight in early childhood, with worsening vision until complete blindness around the age of 30. The study used a common cold virus to deliver a normal version of the gene called RPE65 directly into the eyes of affected patients. All three patients, aged 19, 22 and 25, responded well to the treatment and reported improved vision following the procedure.
Diagnosis
Treatments
Treatment may consist of surgery in the case of tumors, lower doses of estrogen in the case of exogenously-mediated estrogen excess, and estrogen-suppressing medications like gonadotropin-releasing hormone analogues and progestogens. In addition, androgens may be supplemented in the case of males. See also
Aromatase deficiency
Aromatase excess syndrome
Estrogen insensitivity syndrome
High-dose estrogen
Hyperandrogenism
Hypergonadism
Hypergonadotropic hypergonadism
Hypoandrogenism
Hypoestrogenism
Hypogonadism


== References ==