Chemistry
Neostigmine, which can be viewed as a simplified analog of physostigmine, is made by reacting 3-dimethylaminophenol with N-dimethylcarbamoyl chloride, which forms the dimethylcarbamate, and its subsequent alkylation using dimethyl sulfate forming the desired compound. Spectral data
Neostigmine shows notable UV/VIS absorption at 261 nm, 267 nm, and 225 nm.Neostigmines 1H NMR Spectroscopy reveals shifts at:
7.8, 7.7, 7.4, 7.4, 3.8, and 3.1 parts per million. The higher shifts are due to the aromatic hydrogens. The lower shifts at 3.8 ppm and 3.1 ppm are due to the electronic withdrawing nature of the tertiary and quaternary nitrogen, respectively. History
Neostigmine was first synthesized by Aeschlimann and Reinert in 1931 and was patented by Aeschlimann in 1933.Neostigmine is made by first reacting 3-dimethylaminophenol with N-dimethylcarbamoyl chloride, which forms a dimethylcarbamate. Next, that product is alkylated using dimethyl sulfate, which forms neostigmine. : 103

References
External links
"Neostigmine". Drug Information Portal. U.S. National Library of Medicine. "Neostigmine methylsulfate". Drug Information Portal. U.S. National Library of Medicine. "Neostigmine bromide". Drug Information Portal. U.S. National Library of Medicine.
Proximal subungual onychomycosis is an infection of the nail plate by fungus, primarily affecting the proximal nailfold. : 305

See also
Onychomycosis
Skin lesion


== References ==