By the time of the Council of Trent the office of archpriest was replaced by the office of vicar forane, also known in English as "dean". The first recorded use of this meaning of the title comes from St Charles Borromeos reforms in his own diocese. Unlike vicars general and vicars episcopal, vicars forane are not prelates, which means they do not possess ordinary power. Their role is entirely supervisory, and they perform visitations for the bishop and report to the bishop or vicar general any problems in their territory. Exceptionally, the pope on occasion raised a territory to the rank of archipresbyterate nullius, detached from any prelature, yet under a non-prelate, as happened in 1471 with the future abbacy (1583) and later (1828-1986) Diocese of Guastalla. In the 16th and 17th centuries, during the persecution of Catholics in England, an archpriest was appointed by the Holy See as head of the Catholic Church in England, with authority over all of the secular clergy in the country.The title of archpriest has survived in Rome, in Malta and elsewhere, where it is now held by the rectors of the principal basilicas. However, the title is entirely honorary, reflecting the fact that these churches held archpriestly status in the past.
Brody myopathy, also called Brody disease, is a rare disorder that affects skeletal muscle function. BD was first characterized in 1969 by Dr. Irwin A. Brody at Duke University Medical Center. Individuals with BD have difficulty relaxing their muscles after exercise. This difficulty in relaxation leads to symptoms including cramps, stiffness, and discomfort in the muscles of the limbs and face. Symptoms are heightened by exercise and commonly progress in severity throughout adulthood. Signs and symptoms
Symptoms include stiffness and sometimes muscle cramping after exercise and especially when exposed to cold. The most commonly affected muscles are in the arms, legs, and eyelids. Individuals with Brody myopathy also sometimes experience weakness, myalgia, and rhabdomyolysis. Cause
Most cases of BD are inherited through autosomal recessive mutations in ATP2A1,  where each copy of the affected individuals gene contain a mutation. The gene involved in BD encodes the fast-twitch skeletal muscle ATPase, SERCA1. SERCA1 is a protein pump that uses ATP to pump Ca2+ ions from the cytosol to the sarcoplasmic reticulum in skeletal muscle. In those with BD, SERCA1 pumps are unable to effectively move Ca2+ across the membrane, leading to increased levels of cytoplasmic Ca2+. Increases in cytoplasmic Ca2+ levels interfere with muscle contraction, leading to the characteristic symptoms of BD.In some cases of BD, no mutations in ATP2A1 have been observed. Disease transmission in cases of non-ATP2A1 BD have been characterized as autosomal dominant pattern of inheritance.