While the exact etiology of the development of Churg-Strauss symptoms in proximity to initiating zafirlukast is unknown, it is thought that withdrawal of chronic corticosteroids "unmasks" the previously undetected disease. Because corticosteroid withdrawal often happens while starting a new anti-asthma medication (like zafirlukast), this explains the rare but notable association. These cases may represent misdiagnosed asthma, as Churg-Strauss syndrome can induce symptoms of airway obstruction that are akin to an acute asthma exacerbation. As these asthma-like symptoms are reduced by zafirlukast, the symptoms of Churg-Strauss (e.g. neuropathy) increase due to the lack of the broader, anti-inflammatory coverage that the steroid was providing. Overdose
The highest overdose reported with zafirlukast is 200 mg. All overdose patients have survived. Symptoms reported included rash and upset stomach. Interactions
Drug-drug interactions
Zafirlukast is an inhibitor of the hepatic drug-metabolizing enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). Zafirlukast may increase the concentration of drugs that are metabolized through CYP3A4, such as the anticoagulant medication warfarin and the antiepileptic drugs phenytoin and carbamazepine. Drug-food interactions
The oral absorption (bioavailability) of zafirlukast is decreased by 40% when it is taken with high fat or high protein meals. To avoid this interaction, zafirlukast should be taken on an empty stomach. An empty stomach is classified as an hour before, or two hours after, consuming a meal.
Obtain high recognition for the courses of the Skill Centre across the globe
Ensure maximum employment through linking the courses with employment wide industrial tie ups
Offer courses in emerging areas of skill development and entrepreneurshipIn May 2018, The Kerala Academy for Skills Excellence(KASE) decide to partner with The Uralungal Labour Contract Society Ltd(ULCCS) to collaborate in courses offered at IIIC-Kollam under KASE. An MoU in this regard is signed on 30 May in the presence of Labour and Excise Minister for Kerala, T. P. Ramakrishnan. Project details of IIIC-Kollam
Total area - 9.02 acre
Total built up space - 235102 square feet
Blocks - Administrative Block, Training block, Canteen, Substation etc. Total estimated project cost - Rs. 100 Crores
Main Building - 1.5 lakh square feet, 38 classrooms, 10 office rooms, canteen etc. Hostel Building - 35,000 square feet, 54 rooms, Canteen etc. Facilities


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