Lansoprazole, sold under the brand name Prevacid among others, is a medication which reduces stomach acid. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. Effectiveness is similar to other proton pump inhibitors (PPIs). It is taken by mouth. Onset is over a few hours and effects last up to a couple of days.Common side effects include constipation, abdominal pain, and nausea. Serious side effects may include osteoporosis, low blood magnesium, Clostridium difficile infection, and pneumonia. Use in pregnancy and breastfeeding is of unclear safety. It works by blocking H+/K+-ATPase in the parietal cells of the stomach.Lansoprazole was patented in 1984 and came into medical use in 1992. It is available as a generic medication. In 2017, it was the 188th most commonly prescribed medication in the United States, with more than three million prescriptions. Medical uses
Lansoprazole is used for treatment of:
Ulcers of the stomach and duodenum, and NSAID-induced ulcers
Helicobacter pylori infection, alongside antibiotics (adjunctive treatment), treatment to kill H. pylori causing ulcers or other problems involves using two other drugs besides lansoprazole known as "triple therapy", and involves taking twice daily for 10 or 14 days lansoprazole, amoxicillin, and clarithromycin
Gastroesophageal reflux disease
Zollinger–Ellison syndromeThere is no good evidence that it works better than other PPIs.
Availability
Since 2009, lansoprazole has been available over the counter (OTC) in the U.S. as Prevacid 24HR and as Lansoprazole 24HR. In Australia, it is marketed by Pfizer as Zoton. Research
In vitro experiments have shown that lansoprazole binds to the pathogenic form of tau protein. As of 2015 laboratory studies were underway on analogs of lansoprazole to explore their use as potential PET imaging agents for diagnosing tauopathies including Alzheimers disease. References
External links
"Lansoprazole". Drug Information Portal. U.S. National Library of Medicine.