Conversely, SIT1 mutations are believed to result in full expression of iminoglycinuria in some cases where heterozygous mutations of PAT2 would otherwise have only been sufficient to cause hyperglycinuria.Two other transport systems are believed to play subsequent roles in iminoglycinuria, when mutations in them are present. The neutral amino acid transporter SLC6A19 (affecting glycine, proline, and other neutral amino acids like cysteine and tryptophan), associated with Hartnup disease, plays a role in iminoglycinuria as a modifier to PAT2 mutations and is also directly affected by the actions of SIT1. The glycine-specific transporter, SLC6A18, also has an effect on the iminoglycinuria phenotype by either compounding or compensating for failures of glycine transport.To summarize, iminoglycinuria is primarily expressed by homozygous mutations of the PAT2 renal transporter, while the overall iminoglycinuria phenotype may be modified by normal or defective activity of SIT1 (IMINO), SLC6A19 and SLC6A18. Diagnosis
Treament
See also
Pipecolic acid
Facilitated diffusion
Oral rehydration therapy

References


== External links ==
Agriculture
Potassium bicarbonate has widespread use in crops, especially for neutralizing acidic soil.Potassium bicarbonate is an effective fungicide against powdery mildew and apple scab, allowed for use in organic farming. Potassium bicarbonate is a contact killer for Spanish moss when mixed 1/4 cup per gallon. History
The word saleratus, from Latin sal æratus meaning "aerated salt", first used in the nineteenth century, refers to both potassium bicarbonate and sodium bicarbonate. References
External links
Potassium Bicarbonate Handbook
OMRI Potassium Bicarbonate
Safety Data sheet - potassium bicarbonate
"Saleratus" . New International Encyclopedia. 1905.