Linolenic and linoleic acids, two major dietary sources of HDL, are 5 alpha reductase inhibitors. Premature androgenic alopecia and insulin resistance may be a clinical constellation that represents the male homologue, or phenotype, of polycystic ovary syndrome. Others have found a higher rate of hyperinsulinemia in family members of women with polycystic ovarian syndrome. With early-onset AGA having an increased risk of metabolic syndrome, poorer metabolic profiles are noticed in those with AGA, including metrics for body mass index, waist circumference, fasting glucose, blood lipids, and blood pressure.In support of the association, finasteride improves glucose metabolism and decreases glycosylated hemoglobin HbA1c, a surrogate marker for diabetes mellitus. The low SHBG seen with premature androgenic alopecia is also associated with, and likely contributory to, insulin resistance, and for which it still is used as an assay for pediatric diabetes mellitus.Obesity leads to upregulation of insulin production and decrease in SHBG. Further reinforcing the relationship, SHBG is downregulated by insulin in vitro, although SHBG levels do not appear to affect insulin production. In vivo, insulin stimulates both testosterone production and SHBG inhibition in normal and obese men. The relationship between SHBG and insulin resistance has been known for some time; decades prior, ratios of SHBG and adiponectin were used before glucose to predict insulin resistance.
Irregular menstruation is a menstrual disorder whose manifestations include irregular cycle lengths as well as metrorrhagia (vaginal bleeding between expected periods). The possible causes of irregular menstruation may vary. The common factors of it are related to lifestyle, such as stress, body weight, and smoking status. Several studies indicate that COVID-19 vaccine of any type may disrupt the menstrual cycle, although only momentarily. This side effect should resolve on its own in the following month. Irregular cycles or periods
Irregular cycles or irregular periods is an abnormal variation in length of menstrual cycles. An individual usually experiences cycle length variations of up to eight days between the shortest and longest cycle lengths. Lengths ranging between eight and 20 days are considered moderately irregular. Variation of 21 days or more is considered very irregular.Alternatively, a single menstruation cycle may be defined as irregular if it is less than 24 days or more than 38 days. If they are regularly shorter than 21 days or longer than 36 (or 35) days, the condition is termed polymenorrhea or oligomenorrhea, respectively.Additionally, irregular menstruation is common in adolescence. A regular menstrual cycle can be set within a year of menarche. However, other studies suggest that it can take anywhere between 2 and 7 years to establish regularity after an individuals first menses. Other types
Other types of conditions that can be referred to by "irregular menstruation" include:

Metrorrhagia, which generally refers to vaginal bleeding that occurs between the expected menstrual periods. The distinction between irregular cycle lengths and metrorrhagia is not always clear.