Mitochondrial DNA, however, is inherited from the mother only (with some exceptions) and each mitochondrion typically contains between 2 and 10 mtDNA copies. During cell division the mitochondria segregate randomly between the two new cells. Those mitochondria make more copies, normally reaching 500 mitochondria per cell. As mtDNA is copied when mitochondria proliferate, they can accumulate random mutations, a phenomenon called heteroplasmy. If only a few of the mtDNA copies inherited from the mother are defective, mitochondrial division may cause most of the defective copies to end up in just one of the new mitochondria (for more detailed inheritance patterns, see human mitochondrial genetics). Mitochondrial disease may become clinically apparent once the number of affected mitochondria reaches a certain level; this phenomenon is called "threshold expression". Mitochondria possess many of the same DNA repair pathways as nuclei do—but not all of them; therefore, mutations occur more frequently in mitochondrial DNA than in nuclear DNA (see Mutation rate). This means that mitochondrial DNA disorders may occur spontaneously and relatively often. Defects in enzymes that control mitochondrial DNA replication (all of which are encoded for by genes in the nuclear DNA) may also cause mitochondrial DNA mutations. Most mitochondrial function and biogenesis is controlled by nuclear DNA. Human mitochondrial DNA encodes 13 proteins of the respiratory chain, while most of the estimated 1,500 proteins and components targeted to mitochondria are nuclear-encoded.
BC Powder has historically been most commonly associated with relief of headaches. Many users of the brand erroneously believe the name of the product to be "BC Headache Powder." Recent advertising and marketing endeavors by the company suggest that it is eager to associate itself with relief of general bodily aches and pains as well. Goodys Powder, like BC, is also distributed by Prestige Brands. For many years, singer and actor Faron Young was the celebrity featured on many of the products television and radio commercials. For several years, BCs television and radio commercials have featured real-life users of the product, non-actors who are encouraged to submit their stories to BC Powder through contests announced on radio programs. Recently, most entries have been culled from listeners of the Charlotte, NC-based radio program The Big Show with John Boy and Billy. In recent years, members of the Tom Joyner Radio Shows audience have appeared in BC commercials after hearing of the promotion on that program, or from promotions held on Joyners annual "Fantastic Voyage" fantasy cruise. BC Powder also distributes and markets BC Cherry and BC Arthritis Formula. In a deal which took effect in 2012, GlaxoSmithKline (GSK) sold BC Powder and 16 other brands to Prestige Brands. References
External links
Official BC Powder site