Methylphenidate and amphetamine have been investigated as a chemical replacement for the treatment of cocaine addiction in the same way that methadone is used as a replacement drug for physical dependence upon heroin. Its effectiveness in treatment of cocaine or psychostimulant addiction, or psychological dependence has not been proven and further research is needed. References
External links

"Methylphenidate". Drug Information Portal. U.S. National Library of Medicine.
Many common anti-allergy medications are useful because they reduce the mast cells ability to react to histamine.At least one clinical study suggested that nifedipine, a calcium channel blocker used to treat high blood pressure, may reduce mast cell degranulation in patients with urticaria pigmentosa. A 1984 study by Fairly et al. included a patient with symptomatic urticaria pigmentosa who responded to nifedipine at dose of 10 mg po tid. However, nifedipine has never been approved by the FDA for treatment of urticaria pigmentosa. Another mast cell stabilizer Gastrocrom, a form of cromoglicic acid has also been used to reduce mast cell degranulation. Epidemiology
Urticaria pigmentosa is a rare disease, affecting fewer than 200,000 people in the United States. See also
Urticaria
Dermatographic urticaria
Generalized eruption of cutaneous mastocytosis (adult type)

References
Further reading
Alto WA, Clarcq L (June 1999). "Cutaneous and systemic manifestations of mastocytosis". Am Fam Physician. 59 (11): 3047–54, 3059–60. PMID 10392589. == External links ==