Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of pregnancy, jaundice of pregnancy, and prurigo gravidarum, is a medical condition in which cholestasis occurs during pregnancy. It typically presents with itching and can lead to complications for both mother and baby. Pruritus (itching) is a common symptom of pregnancy, affecting around 23% of women. The majority of times, itching is a minor annoyance caused by changes to the skin, especially that of the abdomen. However, there are instances when itching may be a symptom of ICP. Although typically noticed on the palms of the hands and the soles of the feet, the itching can occur anywhere on the body. ICP occurs most commonly in the third trimester, but can begin at any time during the pregnancy. Signs and symptoms
Most women with this condition present in the third trimester (although it can present as early as seven weeks) with itching without a rash. Typically, the itching is localized to the palms of the hands and soles of the feet, but can be anywhere on the body. Hallmarks of ICP include the following symptoms:Most common:

Itching, in particular but not limited to that of the palms of the hands and soles of the feet, without presence of a rash
Itching that is more noticeable in the evening
Darker urineLess common:

Lighter stools
Increased clotting time (due to possibly associated vitamin K deficiency)
Fatigue
Increased nausea
Decrease in appetite
Jaundice (less than 10% of women)
Upper right quadrant painNot all ICP sufferers have all of the above symptoms.
See also
Cholestasis
Cholestatic pruritus
List of cutaneous conditions
Pruritic urticarial papules and plaques of pregnancy (PUPPP) an itchy condition of pregnancy that is associated with a rash. References
External links
E A Fagan "Intrahepatic cholestasis of pregnancy"