It was used both on its own and, in combination with phentermine, as part of the anti-obesity medication Fen-Phen.In June 2020, fenfluramine was approved for medical use in the United States with an indication to treat Dravet syndrome.The effectiveness of fenfluramine for the treatment of seizures associated with Dravet syndrome was demonstrated in two clinical studies in 202 subjects between ages two and eighteen. The studies measured the change from baseline in the frequency of convulsive seizures. In both studies, subjects treated with fenfluramine had significantly greater reductions in the frequency of convulsive seizures during the trials than subjects who received placebo (inactive treatment). These reductions were seen within 3–4 weeks, and remained generally consistent over the 14- to 15-week treatment periods.The U.S. Food and Drug Administration (FDA) granted the application for fenfluramine priority review and orphan drug designations. The FDA granted approval of Fintepla to Zogenix, Inc.On 15 October 2020, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Fintepla, intended for the treatment of seizures associated with Dravet syndrome. Fenfluramine was approved for medical use in the European Union in December 2020. Society and culture
Recreational use
Unlike various other amphetamine derivatives, fenfluramine is reported to be dysphoric, "unpleasantly lethargic", and non-addictive at therapeutic doses.
infection of nose and nasopharynx - 70%
infection of palpebral conjunctiva - 15%

Diagnosis
History
Unilateral nasal obstruction
Epistaxis
Local pruritus
Rhinorrhea
Coryza (rhinitis) with sneezing
Post nasal discharge with cough
Foreign body sensation
History of exposure to contaminated water
Increased tearing and photo phobia in cases of infection of palpebral conjunctiva
On examination
Pink to deep red polyps
Strawberry like appearance
Bleeds easily upon manipulation
Diagnosis
confirmed by biopsy and histopathology - several round or oval sporangia and spores which may be seen bursting through its chitinous wall

Treatment
Surgical excision - wide excision with wide area electro-coagulation of the lesion base
Medical treatment is not so effective but treatment with a year-long course of dapsone has been reported
Recurrence is common

Epidemiology
Disease endemic in Chhattisgarh South India, Sri Lanka, South America and Africa. It is presumed to be transmitted by exposure to the pathogen when taking a bath in stagnant water pools where animals also bathe. References


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