A diagnosis of infective endocarditis is definite if either the following pathological or clinical criteria are met:
One of these pathological criteria:

Histology or culture of cardiac vegetation, embolized vegetation, or intracardiac abscess from the heart finds microorganisms
Active endocarditisOne of these combinations of clinical criteria

Two major clinical criteria
One major and three minor criteria
Five minor criteriaDiagnosis of infective endocarditis is possible if one of the following combinations of clinical criteria is met:

One major and one minor criteria
Three minor criteria are fulfilled

Major criteria
Positive blood culture with typical IE microorganism, defined as one of the following:
Typical microorganism consistent with IE from two separate blood cultures, as noted below:
Viridans-group streptococci, or
Streptococcus bovis including nutritional variant strains, or
HACEK group, or
Staphylococcus aureus, or
Community-acquired enterococci, in the absence of a primary focus
Microorganisms consistent with IE from persistently positive blood cultures defined as:
Two positive cultures of blood samples drawn >12 hours apart, or
Three or a majority of ≥four separate blood cultures (with first and last sample drawn at least one hour apart)
Coxiella burnetii detected by at least one positive blood culture or IgG antibody titer for Q fever phase 1 antigen >1:800.
Pharmacology
Synthesis
Etidronic acid can be prepared by reaction of Phosphorus trichloride with acetic acid in a tertiary amine, or by reaction of an acetic acid/acetic anhydride mixture with phosphorous acid. == References ==