It was already widely used in Italy by the 14th century and lasted until the mid-18th century; it was officially abolished in 1755, or in some regions customary until the mid-19th century.The system of Italian hours can be seen on a number of clocks in Europe, where the dial is numbered from 1 to 24 in either Roman or Arabic numerals. The St Marks Clock in Venice, and the Orloj in Prague are famous examples. It was also used in Poland and Bohemia until the 17th century. The Islamic day begins at sunset. The first prayer of the day (maghrib) is to be performed between just after sunset and the end of twilight. Until 1968 Saudi Arabia used the system of counting 24 equal hours with the first hour starting at sunset. Counting from noon
For many centuries, up to 1925, astronomers counted the hours and days from noon, because it was the easiest solar event to measure accurately. An advantage of this method (used in the Julian Date system, in which a new Julian Day begins at noon) is that the date doesnt change during a single nights observing. Counting from midnight
In the modern 12-hour clock, counting the hours starts at midnight and restarts at noon. Hours are numbered 12, 1, 2, ..., 11. Solar noon is always close to 12 noon (ignoring artificial adjustments due to time zones and daylight saving time), differing according to the equation of time by as much as fifteen minutes either way.
Essential thrombocythemia (ET) is a rare chronic blood cancer (myeloproliferative neoplasm) characterised by the overproduction of platelets (thrombocytes) by megakaryocytes in the bone marrow. It may, albeit rarely, develop into acute myeloid leukemia or myelofibrosis. It is a type of myeloproliferative neoplasm (blood cancers) wherein the body makes too many white or red blood cells, or platelets). Signs and symptoms
Most people with essential thrombocythemia are without symptoms at the time of diagnosis, which is usually made after noting an elevated platelet level on a routine complete blood count (CBC). The most common symptoms are bleeding (due to dysfunctional platelets), blood clots (e.g., deep vein thrombosis or pulmonary embolism), fatigue, headache, nausea, vomiting, abdominal pain, visual disturbances, dizziness, fainting, and numbness in the extremities; the most common signs are increased white blood cell count, reduced red blood cell count, and an enlarged spleen. Cause
In ET, megakaryocytes are more sensitive to growth factors. Platelets derived from the abnormal megakaryocytes are activated, which, along with the elevated platelet count, contributes to the likelihood of forming blood clots. The increased possibility of bleeding when the platelet count is over 1 million is due to von Willebrand factor (vWF) sequestration by the increased mass of platelets, leaving insufficient vWF for platelet adhesion. A mutation in the JAK2 kinase (V617F) is present in 40–50% of cases and is diagnostic if present.