Giant cells – considerably larger than their neighbors – may form and possess either one enormous nucleus or several nuclei (syncytia). Anaplastic nuclei are variable and bizarre in size and shape. invasion or infiltration (medical literature uses these terms as synonymous equivalents. However, for clarity, the articles that follow adhere to a convention that they mean slightly different things; this convention is not followed outside these articles):
Invasion or invasiveness is the spatial expansion of the tumor through uncontrolled mitosis, in the sense that the neoplasm invades the space occupied by adjacent tissue, thereby pushing the other tissue aside and eventually compressing the tissue. Often these tumors are associated with clearly outlined tumors in imaging. Infiltration is the behavior of the tumor either to grow (microscopic) tentacles that push into the surrounding tissue (often making the outline of the tumor undefined or diffuse) or to have tumor cells "seeded" into the tissue beyond the circumference of the tumorous mass; this does not mean that an infiltrative tumor does not take up space or does not compress the surrounding tissue as it grows, but an infiltrating neoplasm makes it difficult to say where the tumor ends and the healthy tissue starts. metastasis (spread to other locations in the body via lymph or blood).Of the above malignant characteristics, some elements do not apply to primary neoplasms of the brain:

Primary brain tumors rarely metastasize to other organs; some forms of primary brain tumors can metastasize but will not spread outside the intracranial cavity or the central spinal canal.
References
External links

MAPS Parent Support group for parents with Anophthalmic and Microphthalmic children
http://www.anophthalmia.org/  ICAN - International Childrens Anophthalmia and Microphthalmia Networkmicrophthalmia]  

MACS - Microphthalmia, Anophthalmia & Coloboma Support Europe’s largest charity supporting people affected by Microphthalmia, Anophthalmia and Coloboma
www.baam.org.uk BAAM Bilateral Anophthalmia and Me
Anophthalmia and Microphthalmia Resource Guide from the National Eye Institute (NEI). GeneReviews/NCBI/NIH/UW entry on Anophthalmia / Microphthalmia Overview
NCBI/Molecular diagnosis of anophthalmia/microphthalmia
MACS The Micro and Anophthalmic Childrens Society - Offers support and Information to families in the UK and around the world