To treat the midface deficiency, surgeons can move the lower orbit and midface bones forward.People with Crouzon syndrome tend to have multiple sutures involved, most specifically bilateral coronal craniosynostoses, and either open vault surgery or strip craniectomy (if the child is under 6 months) can be performed. In the latter scenario, a helmet is worn for several months following surgery.Once treated for the cranial vault abnormalities, Crouzon patients generally go on to live a normal lifespan. Epidemiology
Incidence of Crouzon syndrome is currently estimated at 1.6 out of every 100,000 people. It is the most common craniostenosis syndrome. History
Crouzon syndrome was first described by Octave Crouzon in 1912. He noted the affected patients were a mother and her daughter, implying a genetic basis. See also
Apert syndrome
Treacher Collins syndrome
Hearing loss with craniofacial syndromes

References
External links

Crouzon syndrome on Genetics Home Reference from U.S. National Library of Medicine & National Institutes of Health
GeneReviews/NIH/NCBI/UW entry on FGFR-Related Craniosynostosis Syndromes
Dolutegravir/rilpivirine, sold under the brand name Juluca, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. It contains the medicines dolutegravir and rilpivirine. It is taken by mouth.The most common adverse reactions (of all severity grades) are diarrhea and headache.Dolutegravir/rilpivirine was approved for use in the United States in November 2017, and for use in the European Union in May 2018. Medical uses
Dolutegravir/rilpivirine is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults who are virologically-suppressed (HIV-1 RNA <50 copies/mL) on a stable antiretroviral regimen for at least six months with no history of virological failure and no known or suspected resistance to any non-nucleoside reverse transcriptase inhibitor or integrase inhibitor. References
External links
"Dolutegravir mixture with rilpivirine". Drug Information Portal. U.S. National Library of Medicine.