Norco may refer to:

Places
Norco, California, U.S.
Norco Hills, or La Sierra Heights, section of the Temescal Mountains
Norco, Louisiana, U.S.

Other uses
Norco Bicycles, a Canadian bicycle manufacturer
Norco Co-operative, an agricultural supply and marketing co-operative, New South Wales, Australia
Northern Co-operative Society (Norco), a defunct Aberdeen, Scotland co-operative society
Norco, a brand name for the fixed-dose combination opioid pain medication hydrocodone/paracetamol
NORCO (video game), a point-and-click video game set in a fictional version of Norco, Louisiana

See also
Norco shootout
Pharmacokinetics
Carvedilol is about 25% to 35% bioavailable following oral administration due to extensive first-pass metabolism. Absorption is slowed when administered with food, however, it does not show a significant difference in bioavailability. Taking carvedilol with food decreases the risk of orthostatic hypotension.The majority of carvedilol is bound to plasma proteins (98%), mainly to albumin. Carvedilol is a basic, hydrophobic compound with a steady-state volume of distribution of 115 L. Plasma clearance ranges from 500 to 700 mL/min. Carvedilol is lipophilic and easily crosses the blood–brain barrier in animals, and hence is not thought to be peripherally selective.The compound is metabolized by liver enzymes, CYP2D6 and CYP2C9 via aromatic ring oxidation and glucuronidation, then further conjugated by glucuronidation and sulfation. The three active metabolites exhibit only one-tenth of the vasodilating effect of the parent compound. However, the 4-hydroxyphenyl metabolite is about 13-fold more potent in β-blockade than the parent.The mean elimination half-life of carvedilol following oral administration ranges from 7 to 10 hours. The pharmaceutical product is a mix of two enantiomorphs, R(+)-carvedilol and  S(–)-carvedilol, with differing metabolic properties. R(+)-Carvedilol undergoes preferential selection for metabolism, which results in a fractional half-life of about 5 to 9 hours, compared with 7 to 11 hours for the S(-)-carvedilol fraction. References
Further reading
External links

"Carvedilol". Drug Information Portal. U.S. National Library of Medicine.