Upon binding, the DHT-AR complex translocates from cytoplasm to the nucleus and activates the androgen receptor-regulated genes involved in processes that include male sexual differentiation.Some mutations in 5αR2 impair the synthesis of DHT resulting in 5αR2D. In the male fetus, T mediates Wolffian ductal differentiation while DHT mediates external genital and prostate differentiation. The fact that women with the same 5αR2 mutations as affected male siblings have normal female phenotypes and normal reproductive function supports the notion that 5αR2 does not play an important role in female biology. Most aspects of virilization in male puberty are driven by testosterone, which is why most affected males undergo virilization at that time.Though 5αR2D only affects a small number of people, study of this disorder revealed fundamental aspects of 5α-reductases (including cloning of the underlying genes), androgen action, the process of sexual differentiation, and the factors that influence normal sexual behavior. Genetics
Two of three isozymes of 5αR can catalyze the transformation of T to DHT, but it is only 5αR2D that causes 46XY, DSD. 5αR2 is encoded by the gene SRD5A2 which is located on the short arm of chromosome 2 and contains five exons and four introns. 5αR2 consists of 254 amino acid residues with reported mutations at 67 of them with multiple different mutations at some residues.The first known mutation SRD5A2 was almost a complete deletion which was discovered from analysis of affected males in Papua New Guinean tribe.
An ulcer is a discontinuity or break in a bodily membrane that impedes normal function of the affected organ. According to Robbinss pathology, "ulcer is the breach of the continuity of skin, epithelium or mucous membrane caused by sloughing out of inflamed necrotic tissue." Common forms of ulcers recognized in medicine include:
Ulcer (dermatology), a discontinuity of the skin or a break in the skin. Pressure ulcers, also known as bedsores
Genital ulcer, an ulcer located on the genital area
Ulcerative dermatitis, a skin disorder associated with bacterial growth often initiated by self-trauma
Anal fissure, a.k.a. an ulcer or tear near the anus or within the rectum
Diabetic foot ulcer, a major complication of the diabetic foot
Corneal ulcer, an inflammatory or infective condition of the cornea
Mouth ulcer, an open sore inside the mouth. Aphthous ulcer, a specific type of oral ulcer also known as a canker sore
Peptic ulcer, a discontinuity of the gastrointestinal mucosa (stomach ulcer)
Venous ulcer, a wound thought to occur due to improper functioning of valves in the veins
Stress ulcer, an ulcer located  within the stomach and proximal duodenum
Ulcerative sarcoidosis, a cutaneous condition affecting people with sarcoidosis
Ulcerative lichen planus, a rare variant of lichen planus
Ulcerative colitis, a form of inflammatory bowel disease (IBD). Ulcerative disposition, a disorder or discomfort that causes severe abdominal distress, often associated with chronic gastritis

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