An example of this can be from an accident, which can cause damage to the orbitofrontal cortex area of the brain.Cerebrovascular disease may cause a stroke in the frontal lobe. Tumours such as meningiomas may present with a frontal lobe syndrome. Frontal lobe impairment is also a feature of Alzheimers disease, and frontotemporal dementia. Pathogenesis
The pathogenesis of frontal lobe disorders entails various pathologies, some are as follows:

Anatomy and functions
The frontal lobe contains the precentral gyrus and prefrontal cortex and, by some conventions, the orbitofrontal cortex. These three areas are represented in both the left and the right cerebral hemispheres. The precentral gyrus or primary motor cortex is concerned with the planning, initiation and control of fine motor movements dorsolateral to each hemisphere. The dorsolateral part of the frontal lobe is concerned with planning, strategy formation, and other executive functions. The prefrontal cortex in the left hemisphere is involved with verbal memory while the prefrontal cortex in the right hemisphere is involved in spatial memory. The left frontal operculum region of the prefrontal cortex, or Brocas area, is responsible for expressive language, i.e. language production. The orbitofrontal cortex is concerned with response inhibition, impulse control, and social behaviour. Diagnosis
The diagnosis of frontal lobe disorder can be divided into the following three categories:

Clinical historyFrontal lobe disorders may be recognized through a sudden and dramatic change in a persons personality, for example with loss of social awareness, disinhibition, emotional instability, irritability or impulsiveness. Alternatively, the disorder may become apparent because of mood changes such as depression, anxiety or apathy.
Oral cysts with gastric or intestinal epithelium (oral alimentary tract cyst)
6. Cystic hygroma
7. Nasopharyngeal cyst
8. Thymic cyst
9. Cysts of the salivary glands: mucous extravasation cyst; mucous retention cyst; ranula; polycystic (dysgenetic) disease of the parotid
10. Parasitic cysts: hydatid cyst; Cysticercus cellulosae; trichinosis
Buccal bifurcation cyst
Calcifying odontogenic cyst
Dentigerous cyst (associated with the crowns of non-erupted teeth)
Glandular odontogenic cyst
Keratocyst (in the jaws, these can appear solitary or associated with the Gorlin-Goltz or Nevoid basal cell carcinoma syndrome. Paradental cyst
Periapical cyst (The periapical cyst, otherwise known as radicular cyst, is the most common odontogenic cyst.) Radicular cyst (associated with the roots of non-vital teeth, also known as Periapical cyst)
Residual cyst

Cystic neoplasm
Most cysts in the body are benign (dysfunctional) tumors, the result of plugged ducts or other natural body outlets for secretions. However, sometimes these masses are considered neoplasm:

Keratocyst
Calcifying odontogenic cyst
According to the current (2005) classification of the World Health Organization, both (parakeratizied) odontogenic keratocyst and calcifying odontogenic cyst have neoplastic characteristics, thus renamed as Keratocystic odontogenic tumor and Calcifying odontogenic tumor, respectively. Cystic ameloblastoma
Long standing dentigerous cyst, odontogenic keratocyst, and residual cyst may have neoplastic potential converting into the locally aggressive ameloblastoma, or the malignant squamous cell carcinoma and mucoepidermoid carcinoma. Diagnosis
On histopathology, cholesterol clefts indicate mainly a periapical (radicular) cyst or an inflamed dentigerous cyst. Treatment
Treatment ranges from simple enucleation of the cyst to curettage to resection. For example, small radicular cyst may resolved after successful endodontic ("root-canal") treatment. Because of high recurrence potential and aggressive behaviour, curettage is recommended for keratocyst.