Adverse effects
Cefiderocol may cause serious and life-threatening allergic reactions, severe diarrhea caused by C. difficile and seizures.An increased risk of  all-cause mortality was observed in people treated with cefiderocol as compared to other antibiotics in a separate clinical trial in critically ill people with multidrug-resistant Gram-negative bacterial infections. The higher all-cause mortality rate was observed in people treated for hospital-acquired/ventilator-associated pneumonia (i.e.nosocomial pneumonia), bloodstream infections, or sepsis. The cause of death has not been established, but some of the deaths were a result of worsening or complications of infection, or underlying co-morbidities. The safety and efficacy of cefiderocol has not been established for the treatment of these types of infections. Hence, cefiderocol label includes a warning regarding the higher all-cause mortality rate.Already in 2021, the first cases of antibiotic resistance were reported, and as of 2022 alarming proportions of up to 50% of resistance in some cohorts have been reported. In September 2022, the German RKI reported victims of the Ukraine War with cefidercol resistant surgical infections (Klebsiella specie. and Acinetobacter baumannii) who had been treated in Germany. Pharmacology
Its structure is similar to cefepime and ceftazidime, but a chlorocatechol group at the end of the C-3 side chain further enhances its  β-lactamase  stability and renders it a siderophore.This means it enters into bacterial cells by binding to iron, which is actively transported into the bacterial cells. It was the first siderophore antibiotic to be approved by the U.S. Food and Drug Administration (FDA).
However, as the surveys Arab test persons were mainly recruited from a handful of large and closely related clans living in a particular village, said percentage should be considered with some reservation, according to Goodman et alia (1965). Cases of stub thumbs have also been found in Eastern Nepal for Jirel ethnic individuals from their participation in various epidemiologic studies. Some studies included taking radiographs of hands and wrists to examine their skeletal structure. Of the studied sample (which included 2,130 participants; 969 male and 1,161 female), 3.55% were found to have brachydactyly type D.

Terminology
The condition is known under numerous names. The most commonly used name is clubbed thumb, or club thumb. American researcher R.A. Hefner used the terms "short thumb" and "brachymegalodactylism" in 1924, and "short thumb" has continued to be used in a few other studies since then, including the study that defined Rubinstein–Taybi syndrome in 1963. "Stub thumb" is the common term preferred by the online database Online Mendelian Inheritance in Man and was first used in a 1965 study. Stub thumbs have also been called murderers thumb (allegedly among fortune tellers), bohemian thumb, toe thumb, and potters thumb.The term "clubbed thumb" should not be confused with nail clubbing, which is a clinical sign associated with a number of diseases. == References ==