Examples of unfavorable genes are MCM6 and TIMELESS; an example of a favorable gene is WIPI1.An increased neutorphil-to-lymphocyte ratio is associated with worse outcomes. Epidemiology
Globally, in 2012, melanoma occurred in 232,000 people and resulted in 55,000 deaths. Australia and New Zealand have the highest rates of melanoma in the world. It has become more common in the last 20 years in areas that are mostly Caucasian.The rate of melanoma has increased in the recent years, but it is not clear to what extent changes in behavior, in the environment, or in early detection are involved. Australia
Australia has a very high – and increasing – rate of melanoma. In 2012, deaths from melanoma occurred in 7.3–9.8 per 100,000 population. In Australia, melanoma is the third most common cancer in either sex; indeed, its incidence is higher than for lung cancer, although the latter accounts for more deaths. It is estimated that in 2012, more than 12,000 Australians were diagnosed with melanoma: given Australias modest population, this is better expressed as 59.6 new cases per 100,000 population per year; >1 in 10 of all new cancer cases were melanomas. Melanoma incidence in Australia is matter of significance, for the following reasons:

Australian melanoma incidence has increased by more than 30 per cent between 1991 and 2009. Australian melanoma age-standardised incidence rates were, as of 2008, at least 12 times higher than the world average. Australian melanoma incidence is, by some margin, the highest in the world.
Herodotus writes in The Histories that, to discourage intercourse with a corpse, ancient Egyptians left deceased beautiful women to decay for "three or four days" before giving them to the embalmers. Herodotus also alluded to suggestions that the Greek tyrant Periander had defiled the corpse of his wife, employing a metaphor: "Periander baked his bread in a cold oven." Acts of necrophilia are depicted on ceramics from the Moche culture, which reigned in northern Peru from the first to eighth century CE. A common theme in these artifacts is the masturbation of a male skeleton by a living woman. Hittite law from the 16th century BC through to the 13th century BC explicitly permitted sex with the dead. In what is now Northeast China, the ethnic Xianbei emperor Murong Xi (385–407) of the Later Yan state had intercourse with the corpse of his beloved empress Fu Xunying, after the latter was already cold and put into the coffin.In Renaissance Italy, following the reputed moral collapse brought about by the Black Death and before the Roman Inquisition of the Counter-Reformation, literature was replete with sexual references; these include necrophilia, as in the epic poem Orlando Innamorato by Matteo Maria Boiardo, first published in 1483. In a notorious modern example, American serial killer Jeffrey Dahmer was a necrophiliac. Dahmer wanted to create a sex slave who would mindlessly consent to whatever he wanted.