Patients receiving Angiomax monotherapy had similar rates of overall stent thrombosis (Academic Research Consortium (ARC) definition) at 30 days versus UFH plus a GP IIb/IIIa inhibitor (2.5% vs. 1.9%), with the exception of acute stent thrombosis (<24 hours), which was higher for the bivalirudin-treated patients at 1.3% vs 0.3% for the UFH-GP IIb/IIIa-inhibitor-treated patients.1-Year Results

At 1-year follow-up, a reduction in the incidence of net adverse clinical events (15.7% vs. 18.3%) and major bleeding (5.8% vs. 4.9%) was maintained in the bivalirudin monotherapy group versus UFH plus a GP IIb/IIIa inhibitor group, with no difference in the rate of major adverse cardiovascular events (11.9% vs. 11.9%)
A significant reduction in the rate of cardiac mortality in patients treated with bivalirudin monotherapy versus UFH plus a GP IIb/IIIa inhibitor was maintained at 1 year in the HORIZONS AMI trial (2.1% vs. 3.8%)The incidence of stent thrombosis  at 1 year was also similar between the 2 treatment groups (3.5% in the Angiomax group vs. 3.2% in the UFH plus GP IIb/IIIa inhibitor group).2-Year Results

At 2-year follow-up, a reduction in the incidence of net adverse clinical events (22.3% vs. 24.8%) and major bleeding (6.4% vs. 9.6%) was maintained in the bivalirudin monotherapy group versus UFH plus a GP IIb/IIIa inhibitor group, with no difference in the rate of major adverse cardiovascular events (18.7% vs. 18.8%)
A significant reduction in the rate of cardiac mortality in patients treated with bivalirudin monotherapy versus UFH plus a GP IIb/IIIa inhibitor was maintained at 2 year in the HORIZONS AMI trial (2.5% vs. 4.2%)
At  2-year follow-up, treatment with bivalirudin monotherapy resulted in a 25% reduction in all-cause mortality, representing 15 lives saved per 1000 patients treated (number needed to treat [NNT] = 67 to save 1 life).
Significance
Kerala state depends on migrant workers for the various jobs needed. The dependence on Migrant labourers in Kerala is found mainly in the field of construction. The city of Kollam and other places like Punalur, Paravur in Kollam district, Perumbavoor, Thrissur etc. are slowly becoming overwhelmed with a number of migrants from North India. The migrant labours in places like Kollam have started scoring top marks in literacy equivalent examination. So an institute for developing the unskilled domestic labours as well as migrant labourers has become an essential need in Kerala. The main aim behind this institute is to train masons to upgrade their skills and get a certification from the Britain-based organisation City and Guilds.The flagship project of KASE is the Centre of Excellence in Construction and Infrastructure by the name Indian Institute of Infrastructure and Construction (IIIC). Established in a 9-acre state-of the-art campus at Chavara, Kollam District, Kerala, the objectives of IIIC are broadly to:

Establish a world class Skill Centre, as centre of excellence, for imparting international quality skill sets to the personnel in construction industry of all cadres, right from the labourers to the top managerial personnel under three major categories viz., technician, supervisory and managerial categories. Maximize the reach of the Skill Centre in terms of capacity intake as well as sub sectors covered and the area of reach.