Lyme disease, also known as Lyme borreliosis, is a vector-borne disease caused by the Borrelia bacterium, which is spread by ticks in the genus Ixodes. The most common sign of infection is an expanding red rash, known as erythema migrans, which appears at the site of the tick bite about a week afterwards. The rash is typically neither itchy nor painful. Approximately 70–80% of infected people develop a rash. Early diagnosis can be difficult. Other early symptoms may include fever, headaches and tiredness. If untreated, symptoms may include loss of the ability to move one or both sides of the face, joint pains, severe headaches with neck stiffness or heart palpitations. Months to years later repeated episodes of joint pain and swelling may occur. Occasionally shooting pains or tingling in the arms and legs may develop. Despite appropriate treatment about 10 to 20% of those affected develop joint pains, memory problems and tiredness for at least six months.Lyme disease is transmitted to humans by the bites of infected ticks of the genus Ixodes. In the United States ticks of concern are usually of the Ixodes scapularis type and must be attached for at least 36 hours before the bacteria can spread. In Europe Ixodes ricinus ticks may spread the bacteria more quickly. In North America the bacteria Borrelia burgdorferi and B. mayonii cause Lyme disease. In Europe and Asia Borrelia afzelii, Borrelia garinii, B. spielmanii and four other species also cause the disease.
Haemophilus influenzae: ≥0.8 μg/ml
Pseudomonas aeruginosa: 0.25 μg/ml – 1 μg/ml

Endotoxin adsorption
An effective use of polymyxin B is found in patients with refractory septic shock, that is, without positive outcome to the administration of standard treatments (increase in volemia and other antibiotics). The obstacle of the toxicity of polymyxin B is bypassed by extracorporeal circulation with perfusion of venous blood through a cartridge on whose fibers polymyxin B is covalently fixed; in this way the antibiotic exerts its bactericidal function but is not released into the blood since it remains fully attached to the fiber. Through this perfusion the cartridge retains the endotoxin, recognized as the trigger of septic shock. The treatment of the cartridge to polymyxin B (Toraymyxin, medical device designed and produced by the Japanese Toray), takes place in two sessions of two hours each, carried out at a distance of 24 hours.