Although most commonly found in the wrist, ganglion cysts also may occur in the foot.Ganglion cysts are "commonly observed in association with the joints and tendons of the appendicular skeleton, with 88% in communication with the multiple small joints of the hand and wrist and 11% with those of the foot and ankle". Wrist
They commonly are found near the wrist joint, especially at the scapholunate area.Common wrist ganglions include:

dorsal wrist ganglion
volar wrist ganglion
volar retinaculum ganglion
extensor retinaculum ganglion
occult ganglion
intraosseous ganglion
mucous cyst

Foot
In a 2007 study of patients in Glasgow whose foot lumps were removed surgically, 39 of 101 cases were ganglion cysts. The study replicated earlier findings that no ganglion cysts were found on the sole or heel. The authors wrote, "Although lumps in these areas may be ganglia, the surgeon should probably consider other diagnoses in the first instance." The researchers noted a preponderance of occurrence among females (85%) and that 11 of the other cases had been misdiagnosed as ganglion cysts before surgery.Ganglion cysts are not limited to the hands and feet. They may occur near the knee, commonly near the cruciate ligaments, but they may occur at the origins of the gastrocnemius tendon, and anteriorly on Hoffas infrapatellar fat pad. At the shoulder, they typically occur at the acromioclavicular joint or along the biceps tendon. Other
From their common origin at a joint or tendon, ganglion cysts may form in a wide range of locations. Rarely, intraosseous ganglion cysts occur, sometimes in combination with a cyst in the overlying soft tissue.
Although modest reversal of clozapine-associated weight gain is found with metformin, primary prevention of weight gain is more valuable. Use with insulin
Metformin may reduce the insulin requirement in type 1 diabetes, albeit with an increased risk of hypoglycemia. Life extension
There is some evidence metformin may be helpful in extending lifespan, even in otherwise healthy people. It has received substantial interest as an agent that delays aging, possibly through similar mechanisms as its treatment of diabetes (insulin and carbohydrate regulation). This is controversial, and an area of active research. Alzheimers disease
The possibility that metformin can delay the onset or progression of Alzheimers, or even prevent it, is under investigation. There has been a variety of research published in this field in an effort to establish a correlation between type 2 diabetes and Alzheimers disease. Research now includes studies with participants not diagnosed with diabetes. Contraindications
Metformin is contraindicated in people with:

Severe renal impairment (estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m2)
Known hypersensitivity to metformin
Acute or chronic metabolic acidosis, including diabetic ketoacidosis (from uncontrolled diabetes), with or without comaWarnings are also given regarding the use of metformin in less severe renal impairment, people aged 65 years old or greater,  hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, hepatic impairment, concomitant use of certain drugs (e.g.