The structure of this active compound is characterized as a polyene macrolide with a deoxysugar D-mycosamine, an aminoglycoside. The genomic sequence of nystatin reveals the presence of the polyketide loading module (nysA), six polyketide syntheses modules (nysB, nysC, nysI, nysJ, and nysK) and two thioesterase modules (nysK and nysE). It is evident that the biosynthesis of the macrolide functionality follows the  polyketide synthase I pathway.Following the biosynthesis of the macrolide, the compound undergoes post-synthetic modifications, which are aided by the following enzymes: GDP-mannose dehydratase (nysIII), P450 monooxygenase (nysL and nysN), aminotransferase (nysDII), and glycosyltransferase (nysDI). The biosynthetic pathway is thought to proceed as shown to yield nystatin. The melting point of nystatin is 44 - 46 °C. History
Like many other antifungals and antibiotics, nystatin is of bacterial origin. It was isolated from Streptomyces noursei in 1950 by Elizabeth Lee Hazen and Rachel Fuller Brown, who were doing research for the Division of Laboratories and Research of the New York State Department of Health. Hazen found a promising micro-organism in the soil of a friends dairy farm. She named it Streptomyces noursei, after Jessie Nourse, the wife of the farms owner. Hazen and  Brown named nystatin after the New York State Health Department in 1954. The two discoverers patented the drug, and then donated the $13 million in profits to a foundation to fund similar research. Other uses
It is also used in cellular biology as an inhibitor of the lipid raft-caveolae endocytosis pathway on mammalian cells, at concentrations around 3 μg/ml.
Brand names
The original brandname was Fungicidin

Nyamyc
Pedi-Dri
Pediaderm AF Complete
Candistatin
Nyaderm
Bio-Statin
PMS-Nystatin
Nystan (oral tablets, topical ointment, and pessaries, formerly from Bristol-Myers Squibb)
Infestat
Nystalocal from Medinova AG
Nystamont
Nystop (topical powder, Paddock)
Nystex
Mykinac
Nysert (vaginal suppositories, Procter & Gamble)
Nystaform (topical cream, and ointment and cream combined with iodochlorhydroxyquine and hydrocortisone; formerly Bayer now Typharm Ltd)
Nilstat (vaginal tablet, oral drops, Lederle)
Korostatin (vaginal tablets, Holland Rantos)
Mycostatin (vaginal tablets, topical powder, suspension Bristol-Myers Squibb)
Mycolog-II (topical ointment, combined with triamcinolone; Apothecon)
Mytrex (topical ointment, combined with triamcinolone)
Mykacet (topical ointment, combined with triamcinolone)
Myco-Triacet II (topical ointment, combined with triamcinolone)
Flagystatin II (cream, combined with metronidazole)
Timodine (cream, combined with hydrocortisone and dimethicone)
Nistatina (oral tablets, Antibiotice Iaşi)
Nidoflor (cream, combined with neomycin sulfate and triamcinolone acetonide)
Stamicin (oral tablets, Antibiotice Iaşi)
Lystin
Animax (veterinary topical ointment or cream; combined with neomycin sulfate, thiostrepton and triamcinolone acetonide)
Nyata (topical powder)

References
External links
"Nystatin". Drug Information Portal. U.S. National Library of Medicine.