Positive Histoplasmin skin tests occur in as many as 90% of the people living in areas where H. capsulatum is common, such as the eastern and central United States.In Canada, the St. Lawrence River Valley is the site of the most frequent infections, with 20–30% of the population testing positive. A review of reported cases in 2018 showed disease presence throughout Southeast Asia, In India, the Gangetic West Bengal is the site of most frequent infections, with 9.4% of the population testing positive. H. c. capsulatum was isolated from the local soil proving endemicity of Histoplasmosis in West Bengal. History
Histoplasma was discovered in 1905 by Samuel T. Darling, but only in the 1930s was it discovered to be a widespread infection. Before then, many cases of histoplasmosis were mistakenly attributed to tuberculosis, and patients were mistakenly admitted to tuberculosis sanatoria. Some patients contracted tuberculosis in these sanatoriums. Society and culture
Johnny Cash included a reference to the disease, even correctly noting its source in bird droppings, in the song "Beans for Breakfast". Bob Dylan was hospitalized due to Histoplasmosis in 1997, causing the cancellation of concerts in the United Kingdom and Switzerland. In episode 21 of season three of the television series House M.D., a patient was diagnosed with Histoplasmosis. In episode five of season one of the television series Dexter, Vince Masuka gets worried about getting Histoplasmosis from the dust in the air and the hair of the rats.
Histoplasmosis can also be diagnosed by a test for antibodies against Histoplasma in the blood. Histoplasma skin tests indicate whether persons have been exposed, but do not indicate whether they have the disease. Formal histoplasmosis diagnoses are often confirmed only by culturing the fungus directly. Sabouraud agar is one agar growth medium on which the fungus can be cultured. Cutaneous manifestations of disseminated disease are diverse and often present as a nondescript rash with systemic complaints. Diagnosis is best established by urine antigen testing, as blood cultures may take up to 6 weeks for diagnostic growth to occur and serum antigen testing often comes back with a false negative before 4 weeks of disseminated infection. Types
Histoplasmosis may be divided into these types:: 316–317 
Primary pulmonary histoplasmosis
Progressive disseminated histoplasmosis
Primary cutaneous histoplasmosis
African histoplasmosis

Prevention
Testing or decontaminating most sites that may be contaminated with H. capsulatum is impractical, but the sources below list environments where histoplasmosis is common, and precautions to reduce a persons risk of exposure, in the three parts of the world where the disease is prevalent. Precautions common to all geographical locations would be to avoid accumulations of bird or bat droppings.The US National Institute for Occupational Safety and Health  provides information on work practices and personal protective equipment that may reduce the risk of infection.A review paper includes information on locations in which Histoplasma has been found in Africa (in chicken runs, on bats, in the caves bats inhabit, and in soil), and a thorough reference list including English, French, and Spanish language references.