This process is described by the Schikorr reaction:

  
    
      
        
          
            
              
                3
                
                Fe
                
                  
                    (
                    OH
                    )
                  
                  
                    2
                  
                  
                    
                  
                
              
              
                ferrous
                 
                hydroxide
              
            
          
          ⟶
          
            
              
                
                  Fe
                  
                    3
                  
                  
                    
                  
                
                
                  O
                  
                    4
                  
                  
                    
                  
                
              
              magnetite
            
          
          +
          
            
              
                H
                
                  2
                
                
                  
                
              
              hydrogen
            
          
          +
          
            
              
                2
                
                
                  H
                  
                    2
                  
                  
                    
                  
                
                O
              
              water
            
          
        
      
    
    {\displaystyle {\ce {{\underset {ferrous\ hydroxide}{3Fe(OH)2}}->{\underset {magnetite}{Fe3O4}}+{\underset {hydrogen}{H2}}+{\underset {water}{2H2O}}}}}
  This works because crystalline magnetite (Fe3O4) is thermodynamically more stable than amorphous ferrous hydroxide (Fe(OH)2 ).The Massart method of preparation of magnetite as a ferrofluid, is convenient in the laboratory: mix iron(II) chloride and iron(III) chloride in the presence of sodium hydroxide.A more efficient method of preparing magnetite without troublesome residues of sodium, is to use ammonia to promote chemical co-precipitation from the iron chlorides: first mix solutions of 0.1 M FeCl3·6H2O and FeCl2·4H2O with vigorous stirring at about 2000 rpm.
A serum sialotransferrin type 2 pattern, also observed with WSS, is not present in GO patients.But perhaps the most notable feature, differentiating GO from WSS and similar cutis laxa disorders, is the age-specific metaphyseal peg sometimes found in GO-affected long bone, near the knee. Not appearing until around age 4–5, then disappearing by physeal closure, this oddity of bone is thought to represent a specific genetic marker unique to GO and its effects on bone development. Treatment
See also
Ehlers–Danlos syndromes
Progeria
Skeletal dysplasia

References


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