Nausea due to chemotherapy
Alprazolam may be used in combination with other medications for chemotherapy-induced nausea and vomiting. Contraindications
Benzodiazepines require special precaution if used in children and in alcohol- or drug-dependent individuals. Particular care should be taken in pregnant or elderly people, people with substance use disorder history (particularly alcohol dependence), and people with comorbid psychiatric disorders. The use of alprazolam should be avoided or carefully monitored by medical professionals in individuals with: myasthenia gravis, acute narrow-angle glaucoma, severe liver deficiencies (e.g., cirrhosis), severe sleep apnea, pre-existing respiratory depression, marked neuromuscular respiratory, acute pulmonary insufficiency, chronic psychosis, hypersensitivity or allergy to alprazolam or other benzodiazepines, and borderline personality disorder (where it may induce suicidality and dyscontrol).Like all central nervous system depressants, alprazolam in larger-than-normal doses can cause significant deterioration in alertness and increase drowsiness, especially in those unaccustomed to the drugs effects.Elderly individuals should be cautious in the use of alprazolam due to the possibility of increased susceptibility to side-effects, especially loss of coordination and drowsiness. Side effects
Sedative drugs, including alprazolam, have been associated with an increased risk of death.Possible side effects include:

Anterograde amnesia and concentration problems
Ataxia, slurred speech
Disinhibition
Drowsiness, dizziness, lightheadedness, fatigue, unsteadiness, and impaired coordination, vertigo
Dry mouth (infrequent)
Hallucinations (rare)
Jaundice (very rare)
Seizures (less common)
Skin rash, respiratory depression, constipation
Suicidal ideation or suicide
Urinary retention (infrequent)
Muscle weaknessIn September 2020, the U.S. Food and Drug Administration (FDA) required the boxed warning be updated for all benzodiazepine medicines to describe the risks of abuse, misuse, addiction, physical dependence, and withdrawal reactions consistently across all the medicines in the class.
Treatment
Pain relief is administered concomitantly to the treatment of the primary disease causing tenesmus. See also
Encopresis
Constipation
Fecal incontinence

References
External links

MedlinePlus Encyclopedia: 003131