Although no causal association was proven, there is an association between chronic periodontitis and erectile dysfunction, inflammatory bowel disease, heart disease, and pancreatic cancer. Diabetes and Periodontal Disease
A positive correlation between raised levels of glucose within the blood and the onset or progression of periodontal disease has been shown in the current literature. Data has also shown that there is a significant increase in the incidence or progression of periodontitis in patients with uncontrolled diabetes compared to those who do not have diabetes or have well-controlled diabetes. In uncontrolled diabetes, the formation of reactive oxygen species can damage cells such as those in the connective tissue of the periodontal ligament, resulting in cell necrosis or apoptosis. Furthermore, individuals with uncontrolled diabetes mellitus who have frequent exposure to periodontal pathogens have a greater immune response to these bacteria. This can subsequently cause and/or accelerate periodontal tissue destruction leading to periodontal disease.Oral Cancer and Periodontal Disease
Current literature suggests a link between periodontal disease and oral cancer. Studies have confirmed an increase in systemic inflammation markers such as C-Reactive Protein and Interleukin-6 to be found in patients with advanced periodontal disease. The link between systemic inflammation and oral cancer has also been well established. Both periodontal disease and cancer risk are associated with genetic susceptibility and it is possible that there is a positive association by a shared genetic susceptibility in the two diseases.
Medications
With benign prostatic enlargement causes of LUTS, people may be offered a variety of medications (as a single drug or combining them) when there are persistent moderate symptoms:
Alpha blockers
5-alpha reductase inhibitors
Phosphodiesterase inhibitors
Muscarinic receptor antagonists
Plants extracts (phytotherapy)
Beta-3 agonistIf medical treatment fails, or is not an option; a number of surgical techniques to destroy part or all of the prostate have been developed. Surgical treatment
Surgical treatment of LUTS can include:

Ablation procedures - used in treating both bladder tumours and bladder outlet obstruction, such as prostate conditions. Bladder-neck incision (BNI)
Removal of the prostate - open, robotic, and endoscopic techniques are used. Stenting of the prostate and urethra. Transurethral resection of the prostate (TURP)
Transurethral microwave thermotherapy
Urethral dilatation, a common treatment for strictures. Epidemiology
Prevalence increases with age. The prevalence of nocturia in older men is about 78%. Older men have a higher incidence of LUTS than older women. Around one third of men will develop urinary tract (outflow) symptoms, of which the principal underlying cause is benign prostatic hyperplasia. Once symptoms arise, their progress is variable and unpredictable with about one third of patients improving, one third remaining stable and one third deteriorating. References
Further reading
External links

LUTS in men - Patient.info
LUTS in women - Patient.info