As a consequence, this is often responsible for the astrocytic plaques prominently noted in histological CBD examinations. Although they are understood to play a significant role in neurodegenerative diseases such as CBD, their precise effect remains a mystery.In recent years Corticobasal Degeneration is seen to be a tauopathy[22]. This is believed due to the most common indicator of CBD being a faulty tau protein. Tau proteins are integral in keeping microtubules stable and these defective cells create 4 microtubule-binding repeats[23]. These 4 binding repeats have increased affinity in binding with microtubules[25]. Because of this increased affinity, they form insoluble fibers (also called "paired helical filaments). Microtubules themselves keep the cell and cytoskeletal structure stable[24]. Thus, when Tau proteins create unnatural configurations, microtubules become unstable, and eventually leads to cell death. Diagnosis
New diagnostic criteria known as the Armstrong criteria were proposed in 2013, although the accuracy of these is limited and further research is needed. Criteria
Insidious onset and gradual progression
Lasts 1 year or more
Meets one of the four subtypes:
Possible CBS
FBS or NAV
PSPS plus at least one CBS feature other than limb rigidity or akinesia
No exclusion criteria present
More likely if onset is after age 50
More likely if no family history (2 or more relatives)
More likely if no genetic mutation affecting T (e.g., MAPT)

Possible corticobasal syndrome subtype
Symptoms may be symmetric or asymmetric.
Tailors bunion  is a condition caused as a result of inflammation of the fifth metatarsal bone at the base of the little toe.It is usually characterized by inflammation, pain and redness of the little toe. Often a tailors bunion is caused by a faulty mechanical structure of the foot. The fifth metatarsal bone starts to protrude outward, while the little toe moves inward. This change in alignment creates an enlargement on the outside of the foot. It is mostly similar to a bunion (the same type of ailment affecting the big toe). It is called Tailors bunion because in past centuries, tailors sat cross-legged, and this was thought to cause this protrusion on the outside aspect of the foot. Patients will present with a history of pain of the lateral bunion, plantar callous, and pain that increases with constrictive shoe wear. Studies have shown that tight shoe wear can cause both bunions as well as Tailors bunions. Treatment
Non-surgical therapies include:
Shoe modifications: wearing shoes that have a wide toe box, and avoiding those with pointed toes or high heels. Oral nonsteroidal anti-inflammatory drugs may help in relieving the pain and inflammation. Injections of corticosteroid are commonly used to treat the inflammation. Bunionette pads placed over the affected area may help reduce pain. An ice pack may be applied to reduce pain and inflammation.Surgery is often considered when pain continues for a long period with no improvement in these non-surgical therapies.