Abnormal liver function tests are commonly used to help in diagnosis as the spleen and liver are strongly affected by one another. Splenomegaly
If rheumatoid arthritis is present and other symptoms occur that are not commonly found within RA itself, such as a palpable spleen, further testing should be done. A palpable spleen is not always a clinical significance, therefore CT scan, MRI, or ultrasound can be administered in order to help diagnose the condition. According to Poulin et al., dimensional guidelines for diagnosing splenomegaly are as follows:
Moderate if the largest dimension is 11–20 cm
Severe if the largest dimension is greater than 20 cm

Rheumatoid arthritis
RA in patients with Feltys syndrome is chronic (after 10–15 years), and presents with increased severity along with extra articular manifestations. RA can be mistaken for other conditions such as gout if not clinically diagnosed. Diagnosis can be confirmed by use of X-rays or synovial fluid analysis. Treatment
There is no real treatment for Feltys syndrome, rather the best method in management of the disease is to control the underlying rheumatoid arthritis. Immunosuppressive therapy for RA often improves granulocytopenia and splenomegaly; this finding reflects the fact that Feltys syndrome is an immune-mediated disease. A major challenge in treating FS is recurring infection caused by neutropenia. Therefore, in order to decide upon and begin treatment, the cause and relationship of neutropenia with the overall condition must be well understood. Most of the traditional medications used to treat RA have been used in the treatment of Feltys syndrome.
People in this category did not have a complete set of symptoms in order to be diagnosed with major depression, but still were undoubtedly depressed. The DSM-IV-TR solution to this uncatergorized range of depression was to create Depressive Disorder Not Otherwise Specified (NOS). This group of not specified disorders included minor depressive disorder. In the recent switch to the current DSM-5, minor depressive disorder was dropped from the list of depression disorders. With the disappearance of minor depressive disorder from the DSM-5, there has been confusion between dysthymic disorder, persistent depressive disorder, and minor depressive disorder. Dysthymic disorder was a subsection in the DSM-IV-TR under mood disorders. In the DSM-5, dysthymia is relabeled as "Persistent Depressive Disorder (Dysthymia)". There are differences between persistent depressive disorder and minor depressive disorder including: length of symptom presence, the number of symptoms present, and recurrent periods. The diagnosis of minor depressive disorder has historically been harder to outline, which could have perhaps lead to the disappearance of the disorder. The DSM-IV-TR includes a statement detailing the difficulty of diagnosis, "symptoms meeting research criteria for minor depressive disorder can be difficult to distinguish from periods of sadness that are an inherent part of everyday life". == References ==