In July of that year AstraZeneca licensed tralokinumab to Leo Pharma for skin diseases.A phase IIb study of tralokinumab found that treatment was associated with early and sustained improvements in atopic dermatitis symptoms and tralokinumab had an acceptable safety and tolerability profile, thereby providing evidence for targeting IL-13 in patients with atopic dermatitis.On 15 June 2017, Leo Pharma announced that they were starting phase III clinical trials with tralokinumab in atopic dermatitis. Society and culture
Legal status
On 22 April 2021, the Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Adtralza, intended for the treatment of moderate‑to‑severe atopic dermatitis. The applicant for this medicinal product is LEO Pharma A/S. Tralokinumab was approved for medical use in the European Union in June 2021. Names
Tralokinumab is the international nonproprietary name (INN) and the United States Adopted Name (USAN). References
External links
"Tralokinumab". Drug Information Portal. U.S. National Library of Medicine.
Whereas the hysterias involved at their source a narrowing of the field of consciousness, the psychasthenias involved at root a disturbance in the fonction du reél (function of reality), a kind of weakness in the ability to attend to, adjust to, and synthesise ones changing experience (cf. executive functions in todays empiricist psychologies). Carl Gustav Jung later made the hysteric and the psychasthenic states the prototypes of what he described as extroverted and introverted personalities.Karl Jaspers preserves the term "neurasthenia", defining it in terms of "irritable weakness" and describing phenomena such as irritability, sensitivity, a painful sensibility, abnormal responsiveness to stimuli, bodily pains, strong experience of fatigue, etc. This is contrasted with "psychasthenia", which, following Janet, he describes as a variety of phenomena "held together by the theoretical concept of a diminution of psychic energy." The psychasthenic person prefers to "withdraw from his fellows and not be exposed to situations in which his abnormally strong complexes rob him of presence of mind, memory and poise." The psychasthenic lacks confidence, is prone to obsessional thoughts, unfounded fears, self-scrutiny and indecision. This state in turn promotes withdrawal from the world and daydreaming, yet this only makes things worse. "The psyche generally lacks an ability to integrate its life or to work through and manage its various experiences; it fails to build up its personality and make any steady development." Jaspers believed that some of Janets more extreme cases of psychasthenia were cases of schizophrenia. References


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