Chronic histoplasmosis cases can  resemble tuberculosis; disseminated histoplasmosis affects multiple organ systems and is fatal unless treated.While histoplasmosis is the most common cause of mediastinitis, this remains a relatively rare disease. Severe infections can cause hepatosplenomegaly, lymphadenopathy, and adrenal enlargement. Lesions often left calcification nodules as they are healed.Presumed ocular histoplasmosis syndrome  causes chorioretinitis, where  the choroid and retina of the eyes are scarred, resulting in a loss of vision not unlike macular degeneration. Despite its name, the relationship to Histoplasma is controversial. Distinct from POHS, acute ocular histoplasmosis may rarely occur in immunodeficiency. Complications
In absence of proper treatment and especially in immunocompromised individuals, complications can arise. These include recurrent pneumonia, respiratory failure, fibrosing mediastinitis, superior vena cava syndrome, pulmonary vessel obstruction, and progressive fibrosis of lymph nodes. Fibrosing mediastinitis is a serious complication and can be fatal. Smokers with structural lung disease have higher probability of developing chronic cavitary histoplasmosis.After healing of lesions, hard, calcified lymph nodes can erode the walls of the airway, causing hemoptysis. Mechanisms
H. capsulatum grows in soil and material contaminated with bird or bat droppings (guano). The fungus has been found in poultry-house litter, caves, areas harboring bats, and bird roosts (particularly those of starlings). The fungus is thermally dimorphic; in the environment, it grows as a brownish mycelium, and at body temperature (37°C in humans), it morphs into a yeast. Histoplasmosis is not contagious but is contracted by inhalation of the spores from disturbed soil or guano. The inoculum is represented principally by microconidia.
The mythographer Pherecydes says that Perseus brought the Cyclopes with him from Seriphos to Argos, presumably to build the walls of Mycenae. Proetus, the mythical king of ancient Argos, was said to have brought a group of seven Cyclopes from Lycia to build the walls of Tiryns.The late fifth and early fourth-century BC comic poet Nicophon wrote a play called either Cheirogastores or Encheirogastores (Hands-to-Mouth), which is thought to have been about these Cyclopean wall-builders. Ancient lexicographers explained the title as meaning "those who feed themselves by manual labour", and, according to Eustathius of Thessalonica, the word was used to describe the Cyclopean wall-builders, while "hands-to-mouth" was one of the three kinds of Cyclopes distinguished by scholia to Aelius Aristides. Similarly,  possibly deriving from Nicophons comedy, the first-century Greek geographer Strabo says these Cyclopes were called "Bellyhands" (gasterocheiras) because they earned their food by working with their hands.The first-century natural philosopher Pliny the Elder, in his Natural History, reported a tradition, attributed to Aristotle, that the Cyclopes were the inventors of masonry towers. In the same work Pliny also mentions the Cyclopes, as being among those credited with being the first to work with iron, as well as bronze. In addition to walls, other monuments were attributed to the Cyclopes. For example, Pausanias says that at Argos there was "a head of Medusa made of stone, which is said to be another of the works of the Cyclopes". Principal sources
Hesiod
According to the Theogony of Hesiod, Uranus (Sky) mated with Gaia (Earth) and produced eighteen children.