Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. It may be used to prevent mother-to-child spread during birth or after a needlestick injury or other potential exposure. It is sold both by itself and together as lamivudine/zidovudine and abacavir/lamivudine/zidovudine. It can be used by mouth or by slow injection into a vein.Common side effects include headaches, fever, and nausea. Serious side effects include liver problems, muscle damage, and high blood lactate levels. It is commonly used in pregnancy and appears to be safe for the baby. ZDV is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. It works by inhibiting the enzyme reverse transcriptase that HIV uses to make DNA and therefore decreases replication of the virus.Zidovudine was first described in 1964. It was approved in the United States in 1987 and was the first treatment for HIV. It is on the World Health Organizations List of Essential Medicines. It is available as a generic medication. Medical uses
HIV treatment
AZT is usually dosed twice a day in combination with other antiretroviral therapies. This approach is referred to as Highly Active Antiretroviral Therapy (HAART) and is used to prevent the likelihood of HIV resistance. HIV prevention
AZT has been used for post-exposure prophylaxis (PEP) in combination with another antiretroviral drug called lamivudine. Together they work to substantially reduce the risk of HIV infection following the first single exposure to the virus.
With this curve, the slope of the linear portion, which is the inverse of the compliance of the material, can be obtained. This is then used to derive f(c/a) as defined above in the equation. With the knowledge of all these variables, 
  
    
      
        
          
            K
          
          
            
              c
            
          
        
      
    
    {\textstyle \mathrm {K} _{\mathrm {c} }}
   can then be calculated. Ceramics and inorganic glasses
Ceramics and inorganic glasses have fracturing behavior that differ those of metallic materials. Ceramics have high strengths and perform well in high temperatures due to the material strength being independent of temperature.