With treatment, most people achieve a healthy weight, and the mortality rate for the disease is relatively low. It can vary from being benign to very severe, and people with CD could experience just one episode or have continuous symptoms. It usually reoccurs, although some people can remain disease-free for years or decades. Up to 80% of people with Crohns disease are hospitalized at some point during the course of their disease, with the highest rate occurring in the first year after diagnosis. Most people with Crohns live a normal lifespan. However, Crohns disease is associated with a small increase in risk of small bowel and colorectal carcinoma (bowel cancer). Epidemiology
The percentage of people with Crohns disease has been determined in Norway and the United States and is similar at 6 to 7.1:100,000. The Crohns and Colitis Foundation of America cites this number as approx 149:100,000; NIH cites 28 to 199 per 100,000. Crohns disease is more common in northern countries, and with higher rates still in the northern areas of these countries. The incidence of Crohns disease is thought to be similar in Europe but lower in Asia and Africa. It also has a higher incidence in Ashkenazi Jews and smokers.Crohns disease begins most commonly in people in their teens and 20s, and people in their 50s through to their 70s. It is rarely diagnosed in early childhood. It usually affects female children more severely than males. However, only slightly more women than men have Crohns disease.
Platybasia is a spinal disease of a malformed relationship between the occipital bone and cervical spine. It may be caused by Pagets disease. Platybasia is also a feature of Gorlin-Goltz syndrome, commonly known as basal cell nevus syndrome. It may be developmental in origin or due to softening of the skull base bone, allowing it to be pushed upward. The developmental variant is the result of a wider angle between the skull base of the frontal or anterior fossa and the clivus, which defines the anterior wall of the posterior fossa. It is sometimes associated with other congenital abnormalities of the bone structure, such as fusion of the first cervical vertebrae to the skull atlas assimilation. Further reading
Pearce JM (2007). "Platybasia and basilar invagination". Eur. Neurol. 58 (1): 62–4. doi:10.1159/000102172. PMID 17483591. == External links ==