However, German political theorist Hannah Arendt noted: "Violence can be justifiable, but it never will be legitimate ... Its justification loses in plausibility the farther its intended end recedes into the future. No one questions the use of violence in self-defence, because the danger is not only clear but also present, and the end justifying the means is immediate". Arendt made a clear distinction between violence and power. Most political theorists regarded violence as an extreme manifestation of power whereas Arendt regarded the two concepts as opposites. In the 20th century in acts of democide governments may have killed more than 260 million of their own people through police brutality, execution, massacre, slave labour camps, and sometimes through intentional famine.Violent acts that are not carried out by the military or police and that are not in self-defense are usually classified as crimes, although not all crimes are violent crimes. Damage to property is classified as violent crime in some jurisdictions but not in all. The Federal Bureau of Investigation (FBI) classifies violence resulting in homicide into criminal homicide and justifiable homicide (e.g. self-defense).The criminal justice approach sees its main task as enforcing laws that proscribe violence and ensuring that "justice is done". The notions of individual blame, responsibility, guilt, and culpability are central to criminal justices approach to violence and one of the criminal justice systems main tasks is to "do justice", i.e.
Galloway Mowat syndrome is a very rare autosomal recessive genetic disorder, consisting of a variety of features including hiatal hernia, microcephaly and nephrotic syndrome. Cause
The exact genetic defect in Galloway Mowat syndrome is yet to be discovered. However, mutations in podocyte proteins, such as nephrin, alpha-actinin 4, and podocin, are associated with proteinuria and nephrotic syndrome. There is reduced expression of synaptopodin, GLEPP1, and nephrin in Galloway-Mowat syndrome, but these are likely secondary to the proteinuria, likely not the proteins mutated in Galloway-Mowat syndrome.The biochemical lesion appears to be in the Kinase, Endopeptidase and Other Proteins of small Size (KEOPS)/Endopeptidase-like and Kinase associated to transcribed Chromatin (EKC) (KEOPS/EKC) complex. Sequencing of genes in 37 cases of this condition revealed mutations in the OSGEP, TP53RK, TPRKB and LAGE3 genes all of which encode subunits in the KEOPS complex. Members of this complex are found in bacteria, archaea and eukaryotes and are highly conserved. The function of this complex is still under investigation.The biochemical lesion in this condition appears to be in the N6-threonyl-carbamoylation of adenosine 37 of ANN-type tRNA pathway. This pathway uses two sequentially acting enzymes - YRDC and OSGEP. Mutations in these genes leads to this syndrome. Genetics
Galloway Mowat syndrome is usually an autosomal recessive disorder, which means the defective gene responsible for the disorder is located on an autosome, and two copies of the defective gene (one inherited from each parent) are required in order to be born with the disorder.