Depending on the underlying cause of the cyanosis, additional symptoms may be:
Rapid heartbeat
Rapid respiratory rate
Failure to thrive
Shortness of breath
Nasal flaring
Lethargy
Seizures

Causes
Blue baby syndrome has been attributed to cyanotic congenital heart diseases and methemoglobinemia, however there are additional causes that could result in a baby becoming cyanotic, such as:
Decreased blood perfusion
Pulmonary/lung disorders (ex: Pulmonary hypertension, cystic fibrosis)
Disordered control of breathing (ex: Cyanotic breath-holding spells, seizures)
Airway obstruction
Respiratory distress syndrome

Mechanism
Cyanotic heart disease
Specific types of congenital heart defects that cause blood to pass directly from the right side of the heart to the left side result in cyanosis. In these defects, some of the blood that is pumped to the body has not been oxygenated by the lungs and therefore will appear more blue. Infants with these types of heart defects may have a constant bluish tint to their skin, or they may have temporary episodes of cyanosis. The degree of cyanosis is dependent on how much deoxygenated blood is mixed with oxygenated blood before being pumped to the body. Cardiac conditions in which there is decreased blood flow to the lungs such as, tetralogy of Fallot or pulmonary valve atresia, result in less blood becoming oxygenated. There are also cardiac conditions such as transposition of the great arteries or truncus arteriosus, that results in an overall increase in blood flow to the lungs but with limited flow of the oxygenated blood to the rest of the body.
The operation was published in the Journal of the American Medical Association in 1945 and impacted management of blue babies around the world.Anna was the name of the dog who was the first survivor of the surgery, considered an experimental procedure at the time. Anna survived the first pulmonary bypass after having been operated on twice. The second operation was required to replace the original stitches with flexible ones. After their success with Anna, Blalock and Thomas had the courage to perform the very first open heart surgery on Eileen Saxon in 1944. In 1950, Annas story was made into a movie, and the film has been shown to various schools and other groups. == References ==