However, there was a higher incidence of injection site pain with subcutaneous autoinjection than with intramuscular injection (37.3% vs. 8.2%). Distribution
OHPC is extensively bound to plasma proteins, of which include albumin. Unlike progesterone and 17α-hydroxyprogesterone, OHPC has very low affinity for corticosteroid-binding globulin (less than 0.01% of that of cortisol). Progesterone and 17α-hydroxyprogesterone have low affinity for sex hormone-binding globulin, and for this reason, only a very small fraction of them (less than 0.5%) is bound to this protein in the circulation. Metabolism
OHPC appears to be metabolized primarily by the cytochrome P450 enzymes CYP3A4 and CYP3A5. It may also be metabolized by CYP3A7 in fetal liver and the placenta. Unlike progesterone, OHPC is not metabolized by traditional steroid-transforming enzymes and does not form similar metabolites. The metabolism of OHPC is by reduction, hydroxylation, and conjugation, including glucuronidation, sulfation, and acetylation. The caproate ester of OHPC is not cleaved during metabolism, so 17α-hydroxyprogesterone is not formed from OHPC. As such, OHPC is not a prodrug of 17α-hydroxyprogesterone, nor of progesterone.OHPC has been found to have an elimination half-life of 7.8 days when given by intramuscular injection in an oil-based formulation to non-pregnant women. Its total duration is said to be 10 to 14 days, which is much longer than the duration of intramuscularly administered progesterone in an oil formulation (2 to 3 days). In pregnant women, the elimination half-life of OHPC appears to be longer, about 16 or 17 days.
Amok may refer to:

Running amok, the act of behaving disruptively or uncontrollably. Film
Amok (1934 film), a French film
Amok (1944 film), a Mexican romantic drama
Amok (1983 film), a Moroccan drama

Literature
Amok (comics), an Italian comic book series
Amok (novella), by Stefan Zweig, 1922
Amok, a 1974 novel by Harry Thürk
Amok, a 2003 novel by Krystian Bala

Music
Amok (The Late B.P. Helium album), 2004
Amok (Sentenced album), 1995
Amok (Atoms for Peace album), 2013

Other uses
Steamed curry (Khmer: អាម៉ុក, amŏk), name in Cambodia for a curry steam-cooked in banana leaves
Fish amok, a Cambodian steamed fish curry
Amok (video game), a 1996 video game for the Sega Saturn
Mok language, also known as Amok
Amok (publisher), now Frémok, a Franco-Belgian comics publishing house
Amok Press, a defunct American book imprint

See also
All pages with titles beginning with Amok
All pages with titles containing Amok
"Amok Time", a 1967 episode of Star Trek: The Original Series
Amuck!, a 1972 Italian giallo film
AMOC (disambiguation)