Almotriptan  (trade name Axert and others) is a triptan medication discovered and developed by Almirall for the treatment of heavy migraine headache. It was patented in 1992 and approved for medical use in 2000. Medical uses
Almotriptan is prescribed to treat the acute headache phase of migraine attacks with or without aura. Almotriptan is the only oral triptan approved in the US for the treatment of migraine in adolescent from 12 to 17 years of age. Efficacy
The efficacy and tolerability of almotriptan has been studied in numerous randomised, controlled trials totaling more than 4800 adults with either moderate or severe attacks of migraine. Its efficacy is significantly more effective than placebo and alleviates nausea, photophobia and phonophobia linked to migraine attacks. Almotriptan has similar efficacy as a standard dose of sumatriptan, another triptan drug, and fewer adverse effects. Contraindications
As with other triptans, almotriptan should not be used in patients with a history, symptoms or signs of ischaemic heart disease (myocardial infarction, angina pectoris, documented silent ischaemia, Prinzmetals angina) or severe hypertension and uncontrolled mild or moderate hypertension. Other contraindications are previous cerebrovascular accident (CVA) or transient ischaemic attack (TIA), peripheral vascular disease, severe hepatic impairment, concomitant administration of ergotamine, ergotamine derivatives (including methysergide) and other 5-HT1B/D agonists. Side effects
Almotriptan has proved to have an adverse effects profile similar to placebo when used following the Summary of Product Characteristics instructions (see references). Pharmacology
Mechanism of action
Like all triptans, almotriptan has a high and specific affinity for serotonin 5-HT1B/1D receptors.
Metanx is a prescription medical food made by Alfasigma that contains L-methylfolate (as Metafolin, a calcium salt of vitamin B9), methylcobalamin (vitamin B12) and pyridoxal 5-phosphate (vitamin B6). It is a vitamin B supplement. Metanx is indicated for the dietary management of peripheral neuropathy (i.e. DPN). Ingredients
Metanx contains the following active ingredients (per capsule):

Folate
L-methylfolate (Metafolin): 3 mg
Pyridoxal 5-phosphate: 35 mg
Methylcobalamin: 2 mg

Indication and usage
Metanx is used for treating:

Painful diabetic neuropathy,
Diabetic foot ulcers,
Endothelial dysfunction  associated with diabetic peripheral neuropathy,
Hyperhomocysteinemia. == References ==