Estrogens may be useful in the treatment of schizophrenia in men as well, but their use in this population is limited by feminizing side effects. SERMs, which have few or no feminizing side effects, have been found to be effective in the adjunctive treatment of schizophrenia in men similarly to in women and may be more useful than estrogens in this sex. Sexual deviance
Estradiol has been used at high doses to suppress sex drive in men with sexual deviance such as paraphilias and in sex offenders. It has specifically been used for this indication in the forms of intramuscular injections of estradiol valerate and estradiol undecylate and of subcutaneous pellet implants of estradiol. Available forms
Estradiol is available in a variety of different formulations, including oral, intranasal, transdermal/topical, vaginal, injectable, and implantable preparations. An ester may be attached to one or both of the hydroxyl groups of estradiol to improve its oral bioavailability and/or duration of action with injection. Such modifications give rise to forms such as estradiol acetate (oral and vaginal), estradiol valerate (oral and injectable), estradiol cypionate (injectable), estradiol benzoate (injectable), estradiol undecylate (injectable), and polyestradiol phosphate (injectable; a polymerized ester of estradiol), which are all prodrugs of estradiol. Contraindications
Estrogens like estradiol have a number of contraindications.
In the fresh state its upper part is covered with a thin layer of cartilage, lined by a prolongation of the synovial membrane of the shoulder-joint; its lower portion gives insertion to the tendon of the latissimus dorsi muscle. It is deep and narrow above, and becomes shallow and a little broader as it descends. Its lips are called, respectively, the crests of the greater and lesser tubercles (bicipital ridges), and form the upper parts of the anterior and medial borders of the body of the bone. Shaft
The body or shaft of the humerus is triangular to cylindrical in cut section and is compressed anteroposteriorly. It has 3 surfaces, namely:

Anterolateral surface: the area between the lateral border of the humerus to the line drawn as a continuation of the crest of the greater tubercle. The antero-lateral surface is directed lateralward above, where it is smooth, rounded, and covered by the deltoid muscle; forward and lateralward below, where it is slightly concave from above downward, and gives origin to part of the Brachialis. About the middle of this surface is a rough, rectangular elevation, the deltoid tuberosity for the insertion of the deltoid muscle; below this is the radial sulcus, directed obliquely from behind, forward, and downward, and transmitting the radial nerve and profunda artery. Anteromedial surface: the area between the medial border of the humerus to the line drawn as a continuation of the crest of the greater tubercle.