Bupivacaine/meloxicam, sold under the brand name Zynrelef, is a fixed-dose combination medication used to treat pain in small to medium-sized wounds after surgery. It contains bupivacaine and meloxicam.The most common side effects of bupivacaine/meloxicam are dizziness, constipation, vomiting, and headache.It was approved for medical use in the European Union in September 2020, and in the United States in May 2021. Medical uses
In the European Union, the combination bupivacaine/meloxicam is indicated for treatment of somatic postoperative pain from small- to medium-sized surgical wounds in adults.In the United States it is indicated for soft tissue or periarticular instillation to produce postsurgical analgesia for up to 72 hours after bunionectomy, open inguinal herniorrhaphy, and total knee arthroplasty in adults. References
External links
"Bupivacaine mixture with meloxicam". Drug Information Portal. U.S. National Library of Medicine. Clinical trial number NCT03295721 for "Bunionectomy Study for Postoperative Analgesia (EPOCH 1)" at ClinicalTrials.gov
Clinical trial number NCT03237481 for "Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)" at ClinicalTrials.gov
Clinical trial number NCT03015532 for "Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia" at ClinicalTrials.gov
Late congenital syphilitic oculopathy is a disease of the eye, a manifestation of late congenital syphilis. It can appear as:

Interstitial keratitis – this commonly appears between ages 6 and 12. Symptoms include lacrimation and photophobia. Pathological vascularization of the cornea cause it to turn pink or salmon colored. 90% of cases affect both eyes. Episcleritis or scleritis – nodules appear in or overlying the sclera (white of eye)
Iritis or iris papules – vascular infiltration of the iris causes rosy color change and yellow/red nodules. Chorioretinitis, papillitis, retinal vasculitis – retinal changes can resemble retinitis pigmentosa. Exudative retinal detachmentCongenital syphilis is categorized by the age of the child. Early congenital syphilis occurs in children under 2 years old, and late congenital syphilis in children at or greater than 2 years old. Manifestations of late congenital syphilis are similar to those of secondary syphilis and tertiary syphilis in adults. References

eMedicine: Ocular Manifestations of Syphilis


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