Parasitic infections
In the body, disulfiram is rapidly metabolized to diethyldithiocarbamate (ditiocarb), which binds to metal ions such as zinc or copper to form zinc or copper diethyldithiocarbamate (zinc or copper ditiocarb). The zinc diethyldithiocarbamate (zinc-ditiocarb) metabolite of disulfiram is extremely potent against the diarrhea and liver abscess-causing parasite Entamoeba histolytica and might be active against other deadly parasites. HIV
Disulfiram has also been identified by systematic high-throughput screening as a potential HIV latency reversing agent (LRA). Reactivation of latent HIV infection in patients is part of an investigational strategy known as "shock and kill" which may be able to reduce or eliminate the HIV reservoir. Recent phase II dose-escalation studies in patients with HIV who are controlled on antiretroviral therapy have observed an increase in cell-associated unspliced HIV RNA with increasing exposure to disulfiram and its metabolites. Disulfiram is also being investigated in combination with vorinostat, another investigational latency reversing agent, to treat HIV. COVID-19
Disulfiram has been shown to inhibit the papain-like proteases of MERS-CoV and SARS-CoV. It has been examined in a small inconclusive retrospective observational study for its effects on COVID-19 symptoms and is currently in Phase 2 clinical trials. References
External links
"Disulfiram". Drug Information Portal. U.S. National Library of Medicine. Toxicity, Mushroom - Disulfiramlike Toxins at eMedicine
CDC - NIOSH Pocket Guide to Chemical Hazards
Around 20 cases are diagnosed in America every year – the cause is unknown. It is unresponsive to any known strain of chemotherapy, making treatment very difficult. Society
There is a Facebook site set up for people with EHE. There is also a Registry for patients to enter their medical history. CRAVAT Center for Research and Analysis of VAscular Tumors is a website for the EHE community. The EHE Rare Cancer Foundation Australia was established in 2015 by Australians with Epithelioid Hemangioendothelioma (EHE). The core objective of the EHE Rare Cancer Foundation Australia is to proactively fundraise in order to support research into this rare cancer in the hope that a maintenance program or cure can be found.In 2003 photographer and actress Kris Carr was diagnosed with a stable and low grade version of eHAE. Carr has become a success as a Wellness Warrior advocating a vegan lifestyle as a way to avoid and stabilize disease. See also
List of cutaneous conditions
Skin lesion

References


== External links ==