Other
While inherited deficiencies in uroporphyrinogen decarboxylase often lead to the development of PCT, there are a number of risk factors that can both cause and exacerbate the symptoms of this disease. One of the most common risk factors observed is infection with the Hepatitis C virus. One review of a collection of PCT studies noted Hepatitis C infection in 50% of documented cases of PCT. Additional risk factors include alcohol use disorder, excess iron (from iron supplements as well as cooking on cast iron skillets), and exposure to chlorinated cyclic hydrocarbons and Agent Orange.It can be a paraneoplastic phenomenon. Exacerbating factors
Alcohol
Estrogen
Iron
Hepatitis C virus

Pathogenesis
Porphyria cutanea tarda is primarily caused by uroporphyrinogen decarboxylase deficiency (UROD). Uroporphyrinogen decarboxylase occurs in nature as a homodimer of two subunits. It participates in the fifth step in heme synthesis pathway, and is active in the cytosol. This enzymatic conversion results in coproporphyrinogen III as the primary product. This is accomplished by the clockwise removal of the four carboxyl groups present in the cyclic uroporphyrinogen III molecule. Therefore, a deficiency in this enzyme causes the aforementioned buildup of uroporphyrinogen and hepta-carboxylic porphyrinogen, and to a lesser extent hexa-carboxylic porphyrinogen, and penta-carboxylic porphyrinogen in the urine, which can be helpful in the diagnosis of this disorder.The dermatological symptoms of PCT that include blistering and lesions on sun-exposed areas of the skin are caused by a buildup of porphyrin compounds (specifically uroporphyrinogen) close to the surface of the skin that have been oxidized by free radicals or sunlight.
A small waist to hip ratio indicates less android fat, high waist to hip ratios indicate high levels of android fat.As  WHR is associated with a womans pregnancy rate, it has been found that a high waist-to-hip ratio can impair pregnancy, thus a health consequence of high android fat levels is its interference with the success of pregnancy and in-vitro fertilisation. Body fat distribution is also related to the sex ratio of offspring. Women with large waists (a high WHR)  tend to have an android fat distribution caused by a specific hormone profile, that is, having higher levels of androgens. This leads to such women having more sons. Liposuction
Liposuction is a medical procedure used to remove fat from the body, common areas being around the abdomen, thighs and buttocks. Liposuction does not improve an individuals health or insulin sensitivity  and is therefore considered a cosmetic surgery. liposuction improves quality of life in everyday activities and issues regarding ones psychological state or social life after liposuction are less serious. It has been found that abdominal exercise alone cannot reduce android fat around the trunk and abdomen  so liposuction is often a short term solution. As liposuction can lower a persons waist–hip ratio by removing fat from locations where android fat accumulates, it can give the appearance of a more attractive body shape, and imitate an indication of reproductive health.