The posterior division gives off only one branch, which is the saphenous nerve. Articular branches
Hip joint is supplied by nerve to the rectus femoris. Knee joint is supplied by the nerves to the three vasti. The nerve to vastus medialis is particularly thick because it contains the proprioceptive fibres from the knee joint. This is in accordance to the Hiltons law. Vascular branches
Branches to the femoral artery and its branches. Clinical significance
Signals from the femoral nerve and its branches can be blocked to interrupt transmission of pain signal from the innervation area, by performing a regional nerve blockage. Some of the nerve blocks that work by affecting the femoral nerve are the femoral nerve block, the fascia iliac block and the 3-in-1 nerve block. Femoral nerve blocks are very effective.During pelvic surgery and abdominal surgery, the femoral nerve must be identified early on to protect it from iatrogenic nerve injury.The femoral nerve stretch test can be performed to identify the compression of spinal nerve roots. The test is positive if thigh pain increases.
Bruck syndrome is characterized as the combination of arthrogryposis multiplex congenita and osteogenesis imperfecta. Both diseases are uncommon, but concurrence is extremely rare which makes Bruck syndrome very difficult to research. Bruck syndrome is thought to be an atypical variant of osteogenesis imperfecta most resembling type III, if not its own disease. Multiple gene mutations associated with osteogenesis imperfecta are not seen in Bruck syndrome. Many affected individuals are within the same family, and pedigree data supports that the disease is acquired through autosomal recessive inheritance. Bruck syndrome has features of congenital contractures, bone fragility, recurring bone fractures, flexion joint and limb deformities, pterygia, short body height, and progressive kyphoscoliosis. Individuals encounter restricted mobility and pulmonary function. A reduction in bone mineral content and larger hydroxyapatite crystals are also detectable Joint contractures are primarily bilateral and symmetrical, and most prone to ankles. Bruck syndrome has no effect on intelligence, vision, or hearing. Genetics
The genetics of Bruck syndrome differs from osteogenesis imperfecta. Osteogenesis imperfecta involves autosomal dominant mutations to Col 1A2 or Col 1A2 which encode type 1 procollagen. Bruck syndrome is linked to mutations in two genes, and therefore is divided in two types. Bruck syndrome type 1 is caused by a homozygous mutation in the FKBP10 gene. Type 2 is caused by a homozygous mutation in the PLOD2 gene. Mechanism
Type 1  encodes FKBP65, an endoplasmic reticulum associated peptidyl-prolyl cis/trans isomerase (PPIase) that functions as a chaperone in collagen biosynthesis.