Attempted suicide by intake of a large dose of quinine has caused irreversible tunnel vision and very severe visual impairment.Patients treated with quinine may also suffer from low blood sugar, especially if it is administered intravenously, and hypotension (low blood pressure).Quinine, like chloroquine, inactivates enzymes in the lysosomes of cells and has an anti-inflammatory effect, hence its use in the treatment of rheumatoid arthritis. However, inactivation of these enzymes can also cause abnormal accumulation of glycogen and phospholipids in lysosomes, causing toxic myopathy. It is possible this action is the root cause of cinchonism. References
External links
Lin, Xi; Chen, Shanping; Tee, Daniel (May 1998). "Effects of Quinine on the Excitability and Voltage-Dependent Currents of Isolated Spiral Ganglion Neurons in Culture". Journal of Neurophysiology. 79 (5): 2503–12. doi:10.1152/jn.1998.79.5.2503. PMID 9582223.
Damage to the cardio-respiratory centers in the medulla oblongata will cause respiratory arrest and (secondarily) cardiac arrest. Investigation is underway regarding the use of neuroprotective agents during the prolonged post-traumatic period of brain hypersensitivity associated with the syndrome. See also
Second-impact syndrome

References


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