Preliminary in vivo experiments show a decrease in C(max) and a longer half-life with the liposomal formulation. The drug antibody eribulin combination therapy is a joint venture between Eisai and Merck. The clinical trials combine eribulin and pembrolizumab, a PD-1 inhibitor, for the treatment of breast cancer and other advanced cancers. Intellectual Property
Currently there are five active patents in the United States that are associated with the Halaven drug application, N201532. The first one expired on June 16, 2019, the last one (USRE46965) expires on January 8, 2027. References
External links
"Eribulin". Drug Information Portal. U.S. National Library of Medicine. "Eribulin mesylate". Drug Information Portal. U.S. National Library of Medicine.
An estimated 75% of volcanic eruptive volume is generated by submarine eruptions near mid ocean ridges alone, however problems detecting deep sea volcanics meant they remained virtually unknown until advances in the 1990s made it possible to observe them.Submarine eruptions may produce seamounts, which may break the surface and form volcanic islands. Submarine volcanism is driven by various processes. Volcanoes near plate boundaries and mid-ocean ridges are built by the decompression melting of mantle rock that rises on an upwelling portion of a convection cell to the crustal surface. Eruptions associated with subducting zones, meanwhile, are driven by subducting plates that add volatiles to the rising plate, lowering its melting point. Each process generates different rock; mid-ocean ridge volcanics are primarily basaltic, whereas subduction flows are mostly calc-alkaline, and more explosive and viscous.Spreading rates along mid-ocean ridges vary widely, from 2 cm (0.8 in) per year at the Mid-Atlantic Ridge, to up to 16 cm (6 in) along the East Pacific Rise. Higher spreading rates are a probable cause for higher levels of volcanism. The technology for studying seamount eruptions did not exist until advancements in hydrophone technology made it possible to "listen" to acoustic waves, known as T-waves, released by submarine earthquakes associated with submarine volcanic eruptions. The reason for this is that land-based seismometers cannot detect sea-based earthquakes below a magnitude of 4, but acoustic waves travel well in water and over long periods of time.