School age children tend to have fewer medical issues requiring hospitalization, though frequent infections, hearing loss and feeding issues occur. In addition, intellectual impairment, difficulty with visuospatial tasks and maintaining attention usually require an IEP (individualized education plan) if the child attends public school. Older children and adults report difficulties with anxiety. Endocrine abnormalities and immune system abnormalities such as ITP (idiopathic thrombocytopenia) and CVID (common variable immune deficiency) are medical issues that tend to present in older children, adolescents and adults. Causes
Type 1 Kabuki syndrome is caused by germline heterozygous loss of function variants in KMT2D (formerly known as the MLL2), located on human chromosome 12. It is estimated that between 55 and 80% of cases of Kabuki syndrome are of Type 1. Type 1 Kabuki syndrome demonstrates an autosomal dominant pattern of inheritance. Type 2 Kabuki syndrome is caused by germline hemizygous (in males) or heterozygous (in females) chromosome deletions or loss of function point variants involving KDM6A, located on the X chromosome. Approximately 5% of cases of Kabuki syndrome are of Type 2. Type 2 Kabuki syndrome demonstrates an X-linked dominant pattern of inheritance.Most cases of Kabuki syndrome occur de novo, that is, the parents are unaffected and the gene was mutated early in embryological development. However, several cases of inherited mutations causing Type 1 or Type 2 Kabuki syndrome are now known.About 30% of cases have no identifiable causative mutation.
Immersion may refer to:

The arts
"Immersion", a 2012 story by Aliette de Bodard
Immersion, a French comic book series by Léo Quievreux
Immersion (album), the third album by Australian group Pendulum
Immersion (film), a 2021 Chilean thriller film
Immersion (series), a webseries which test the concepts of video games in real life, created by Rooster Teeth Productions
Immersion journalism, a style of journalism

Science and technology
Immersion lithography or immersion microscopy, optical techniques in which liquid is between the objective and image plane in order to raise numerical aperture
Immersion (mathematics), a smooth map whose differential is everywhere injective, related to the mathematical concept of an embedding
Immersion (virtual reality), the perception of being physically present in a non-physical world, created by using VR

Other uses
Immersion baptism, a type of baptism whereby the subject is immersed in water
Immersion Corporation, a haptic technology developer
Immersion heater, a kind of water heater
Immersion therapy, overcoming fears through confrontation
Language immersion, a method of teaching a second language in which the target language is used for instruction