Noritate is a topical cream usually prescribed for rosacea, a disease of the skin commonly associated with adult acne and most notably frequent to constant flushing of the face around the cheeks and chin area.Noritate contains 1% anti-inflammatory drug metronidazole designed to reduce redness in inflamed areas. While noritate may get rid of some pustules and reduce redness, it has been shown to result in acne in an exceptionally small number of users. The drug information pamphlet claims only 1% of users see ill effects. In many cases, users see no reduction in general redness associated with rosacea and sometimes even a worsening effect. Similar results are reported for Metrogel, which contains the same 1% metronidazole. == References ==
Tachycardia-induced cardiomyopathy (TIC) is a disease where prolonged tachycardia (a fast heart rate) or arrhythmia (an irregular heart rhythm) causes an impairment of the myocardium (heart muscle), which can result in heart failure. People with TIC may have symptoms associated with heart failure (e.g. shortness of breath or ankle swelling) and/or symptoms related to the tachycardia or arrhythmia (e.g. palpitations). Though atrial fibrillation is the most common cause of TIC, several tachycardias and arrhythmias have been associated with the disease.There are no formal diagnostic criteria for TIC. Thus, TIC is typically diagnosed when (1) tests have excluded other causes of cardiomyopathy and (2) there is improvement in myocardial function after treatment of the tachycardia or arrhythmia. Treatment of TIC can involve treating the heart failure as well as the tachycardia or arrhythmia. TIC has a good prognosis with treatment, with most people recovering some to all of their heart function.The number of cases that occur is unclear. TIC has been reported in all age groups. Signs and symptoms
People with TIC most often present with symptoms of congestive heart failure and/or symptoms related to their irregular heart rhythm. Symptoms of congestive heart failure can include shortness of breath, ankle swelling, fatigue, and weight gain. Symptoms of an irregular heart rhythm can include palpitations and chest discomfort.The timecourse of TIC is most well-studied in experiments on animals. Researchers have found that animals began to exhibit abnormal changes in blood flow after just one day of an artificially generated fast heart rate (designed to simulate a tachyarrythmia).