The revised labels restrict use to patients already taking a rosiglitazone-containing medicine or to new patients who are unable to achieve adequate glycemic control on other diabetes medications and to those, who in consultation with their healthcare provider, have decided not to take Actos (pioglitazone) or other pioglitazone-containing medicines for medical reasons.In June 2013 an FDA Advisory Committee reviewed all available data, including a re-adjudicated RECORD trial, found no evidence of increased cardiovascular risk with Avandia, and voted to remove the restrictions on Avandia marketing in the United States. In November 2013, the US FDA removed these marketing restrictions on the product. Under the FDAs instruction, Avandias maker, GlaxoSmithKline, had funded the Duke Clinical Research Institute to re-analyze the raw data from the study. At the 2010 panel, three panelists voted that the existing warnings were good enough; two were back in 2013. Seven voted to make those warnings more onerous, and five of them returned. But of the 10 who voted to restrict Avandias use, only four returned. And of the 12 who voted in 2010 to withdraw Avandia from the market, only three came back. European investigations
In 2000 a study to address the concerns regarding cardiovascular safety was requested by the EMA, and the makers agreed to perform post-marketing a long-term cardiovascular morbidity/mortality study in patients on rosiglitazone in combination with a sulfonylurea or metformin: the RECORD study.
A. astronyxis (Ray & Hayes 1954) Page 1967 * (T7)
A. byersi Qvarnstrom, Nerad & Visvesvara 2013 *
A. castellanii Volkonski 1931 * (T4) [A. terricola Pussard 1964]
A. comandoni Pussard 1964 (T9)
A. culbertsoni (Singh & Das 1970) Griffin 1972 * (T10)
A. divionensis Pussard & Pons 1977 (T4)
A. echinulata Pussard & Pons 1977
A. gigantea Schmöller 1964
A. glebae (Dobell 1914)
A. gleichenii Volkonsky 1931
A. griffini Sawyer 1971 (T3)
A. hatchetti Sawyer, Visvesvara & Harke 1977 * (T11)
A. healyi Moura, Wallace & Visvesvara 1992 (T12)
A. hyalina Dobel & Oconnor 1921
A. jacobsi Sawyer, Nerad & Visvesvara 1992
A. keratitis  *
A. lenticulata Molet & Ermolieff-braun 1976 (T3)
A. lugdunensis Pussard & Pons 1977 * (T4)
A. mauritaniensis Pussard & Pons 1977 (T4)
A. micheli Corsaro et al. 2015
A. palestinensis (Reich 1933) Page 1977 * (T1)
A. paradivionensis Pussard & Pons 1977 (T4)
A. pearcei Nerad et al. 1995
A. polyphaga (Puschkarew 1913) Volkonsky 1931 * (T4)
A. pustulosa Pussard & Pons 1977 (T2)
A. pyriformis (Olive & Stoianovitch 1969) Spiegel & Shadwick 2016
A. quina Pussard & Pons 1977 *
A. rhysodes (Singh 1952) Griffin 1972 * (T4)
A. royreba Willaert, Stevens & Tyndall 1978
A. sohi Kyung-il & Shin 2003
A. stevensoni Sawyer et al. 1993 (T11)
A. triangularis Pussard & Pons 1977 (T4)
A. tubiashi Lewis & Sawyer 1979 (T8)

Etymology
From the Greek akantha (spike/thorn), which was added before "amoeba" (change) to describe this organism as having a spine-like structure (acanthopodia). This organism is now well known as Acanthamoeba, an amphizoic, opportunistic, and nonopportunistic protozoan protist widely distributed in the environment.