Children with JMML and neurofibromatosis 1 (NF1) (about 14% of children with JMML are also clinically diagnosed with NF1, though up to 30% carry the NF1 gene mutation) may also exhibit any of the following symptoms associated with NF1 (in general, only young children with NF1 are at an increased risk of developing JMML):
6 or more café-au-lait (flat, coffee-colored) spots on the skin
2 or more neurofibromas (pea-size bumps that are noncancerous tumors) on or under the skin
Plexiform neurofibromas (larger areas on skin that appear swollen)
Optic glioma (a tumor on the optic nerve that affects vision)
Freckles under the arms or in the groin
2 or more Lisch nodules (tiny tan or brown-colored spots on the iris of the eye)
Various bone deformations including bowing of the legs below the knee, scoliosis, or thinning of the shin boneNoonan syndrome (NS) may predispose to the development of JMML or a myeloproliferative disorder (MPD) associated with NS (MPD/NS) which resembles JMML in the first weeks of life. However, MPD/NS may resolve without treatment. Children with JMML and Noonans syndrome may also exhibit any of the following most-common symptoms associated with Noonans syndrome:
Congenital heart defects, in particular, pulmonic stenosis (a narrowing of the valve from the heart to the lungs)
Undescended testicles in males
Excess skin and low hair line on back of neck
Widely set eyes
Diamond-shaped eyebrows
Ears that are low-set, backward-rotated, thick outer rim
Deeply grooved philtrum (upper lip line)
Learning delays

Genetics
About 90% of JMML patients have some sort of genetic abnormality in their leukemia cells that can be identified with laboratory testing.
The Centers for Disease Control and Prevention (CDC) recommends trichomoniasis testing for females with vaginal discharge and can be considered for females at higher risk for infection or of HIV-positive serostatus.The advent of new, highly specific and sensitive trichomoniasis tests present opportunities for new screening protocols for both men and women. Careful planning, discussion, and research are required to determine the cost-efficiency and most beneficial use of these new tests for the diagnosis and treatment of trichomoniasis in the U.S., which can lead to better prevention efforts.A number of strategies have been found to improve follow-up for STI testing including email and text messaging as reminders of appointments. Screening
Evidence from a randomized controlled trials for screening pregnant women who do not have symptoms for infection with trichomoniasis and treating women who test positive for the infection have not consistently shown a reduced risk of preterm birth. Further studies are needed to verify this result and determine the best method of screening. In the US, screening of pregnant women without any symptoms is only recommended in those with HIV as Trichomonas infection is associated with increased risk of transmitting HIV to the fetus. Treatment
Treatment for both pregnant and non-pregnant women is usually with metronidazole, by mouth once. Caution should be used in pregnancy, especially in the first trimester. Sexual partners, even if they have no symptoms, should also be treated. Single oral dose of nitroimidazole is sufficient to kill the parasites.For 95–97% of cases, infection is resolved after one dose of metronidazole.