Adverse events
The most common adverse events reported in clinical studies were mild or moderate reactions involving the skin and appendages (primarily urticaria, rash, or pruritus), which occurred in 14 out of 42 patients. Three patients experienced a serious adverse event. Two patients had a severe allergic reaction (severe hives and a severe rash and pruritus) following treatment. One patient had a recurrent coagulopathy due to envenomation, which required re-hospitalisation and additional antivenin administration. In clinical trials, recurrent coagulopathy (the return of a coagulation abnormality after it has been successfully treated with antivenin), characterised by decreased fibrinogen, decreased platelets and elevated prothrombin time, occurred in approximately half of the patients studied. Recurrent coagulopathy may persist for one to two weeks or more. One patient discontinued CroFab therapy due to an allergic reaction. Patients with allergies to papain, chymopapain, other papaya extracts or the pineapple enzyme bromelain may also be at risk for an allergic reaction to CroFab. Cost
Leslie Boyer, Director of the VIPER Institute, who was on the team that developed CroFab, said they were "crestfallen" to discover that the wholesale price of Anascorp, their latest antivenom, was too high to be cost effective, even in the treatment of critically ill children. The industry website Fierce Pharma called the product a “drug launch disaster” and “one of the most bizarre marketing tales in the industry.” Boyer said that CroFab, a US drug whose sister product retailed in Mexico at $100, was resulting in bills to Arizona patients of between $7,900 and $39,652 per vial.
Procedure may refer to:

Medical procedure
Instructions or recipes, a set of commands that show how to achieve some result, such as to prepare or make something
Procedure (business), specifying parts of a business process
Standard operating procedure, a step-by-step instruction to achieve some result, used in industry and military
Legal procedure, the body of law and rules used in the administration of justice in the court system, including:
Civil procedure
Criminal procedure
Administrative procedure
Parliamentary procedure, a set of rules governing meetings
Procedure (computer science), also termed a subroutine, function, or subprogram
Stored procedure, a subroutine in the data dictionary of a relational database
The Procedure, an American hardcore band

See also
Procedural (disambiguation)