It also causes a decrease in glucose-6-phosphate dehydrogenase which may results in glucose-6-phosphate dehydrogenase deficiency known as favism, a condition that predisposes to hemolysis (spontaneous destruction of red blood cells). Acute and chronic exposure also reduces glutathione reductase, an enzyme that catalyzes the reduction of glutathione disulfide (GSSG) to the sulfhydryl form glutathione (GSH), which is a critical molecule in resisting oxidative stress and maintaining the reducing environment of the cell. Reproductive effects
Exposure to nitrogen dioxide has a significant effect on the male reproductive system by inhibiting the production of Sertoli cells, the "nurse" cells of the testicles that are part of a seminiferous tubule and help in the process of spermatogenesis. These effects consequently retard the production of sperm cells. The effects of nitrogen dioxide poisoning on female reproduction may be linked with the effects of oxidative stress on female reproduction. Nitrogen dioxide poisoning disrupts the balance of reactive oxygen species (ROS), which results in oxidative stress, leading to significant effects on the female reproductive lifespan. ROS play a significant role in body physiology, from oocyte production, development and maturation to fertilization, development of the embryo and gestation. Exposure to nitrogen dioxide causes ovulation-induced oxidative damage to the DNA of ovarian epithelium. There is a growing body of literature on the pathological effects of ROS on female reproduction as evidenced by free-radical-induced birth defects, abortions, hydatidiform moles and pre-eclampsia. ROS also play a significant role in the etiopathogenesis of endometriosis, a disease in which tissue that normally grows inside the uterus grows outside of it.
Procedure may refer to:

Medical procedure
Instructions or recipes, a set of commands that show how to achieve some result, such as to prepare or make something
Procedure (business), specifying parts of a business process
Standard operating procedure, a step-by-step instruction to achieve some result, used in industry and military
Legal procedure, the body of law and rules used in the administration of justice in the court system, including:
Civil procedure
Criminal procedure
Administrative procedure
Parliamentary procedure, a set of rules governing meetings
Procedure (computer science), also termed a subroutine, function, or subprogram
Stored procedure, a subroutine in the data dictionary of a relational database
The Procedure, an American hardcore band

See also
Procedural (disambiguation)