However, clinical trials have developed certain compounds that could potentially change the future of Alzheimers disease treatments. Currently, diagnoses of Alzheimers is subpar, and better methods need to be utilized for various aspects of clinical diagnoses. Alzheimers has a 20% misdiagnosis rate.AD pathology is primarily characterized by the presence of amyloid plaques and neurofibrillary tangles. Plaques are made up of small peptides, typically 39–43 amino acids in length, called amyloid beta (also written as A-beta or Aβ). Amyloid beta is a fragment from a larger protein called amyloid precursor protein (APP), a transmembrane protein that penetrates through the neurons membrane. APP appears to play roles in normal neuron growth, survival and post-injury repair. APP is cleaved into smaller fragments by enzymes such as gamma secretase and beta secretase. One of these fragments gives rise to fibrils of amyloid beta which can self-assemble into the dense extracellular amyloid plaques. Parkinsons disease
Parkinsons disease (PD) is the second most common neurodegenerative disorder. It typically manifests as bradykinesia, rigidity, resting tremor and posture instability. The crude prevalence rate of PD has been reported to range from 15 per 100,000 to 12,500 per 100,000, and the incidence of PD from 15 per 100,000 to 328 per 100,000, with the disease being less common in Asian countries. PD is primarily characterized by death of dopaminergic neurons in the substantia nigra, a region of the midbrain. The cause of this selective cell death is unknown. Notably, alpha-synuclein-ubiquitin complexes and aggregates are observed to accumulate in Lewy bodies within affected neurons.
Metanx is a prescription medical food made by Alfasigma that contains L-methylfolate (as Metafolin, a calcium salt of vitamin B9), methylcobalamin (vitamin B12) and pyridoxal 5-phosphate (vitamin B6). It is a vitamin B supplement. Metanx is indicated for the dietary management of peripheral neuropathy (i.e. DPN). Ingredients
Metanx contains the following active ingredients (per capsule):

Folate
L-methylfolate (Metafolin): 3 mg
Pyridoxal 5-phosphate: 35 mg
Methylcobalamin: 2 mg

Indication and usage
Metanx is used for treating:

Painful diabetic neuropathy,
Diabetic foot ulcers,
Endothelial dysfunction  associated with diabetic peripheral neuropathy,
Hyperhomocysteinemia. == References ==