Children and Teenagers
It is not recommended for children under the age of 18 to consume several caffeinated drinks according to the American Academy of Pediatrics (AAP). If they were to consume caffeine it is recommended to follow some guidelines so they do not consume too much throughout the day. If they do, they can become dependent on caffeine and without it can suffer many different side effects. These include increase of heart rate and blood pressure, sleep disturbance, mood swings, and acidic problems. Long lasting problems on childrens nervous system and cardiovascular system are currently unknown and studies are still being conducted on it. Tolerance
Tolerance levels regarding caffeine typically vary from person to person. Caffeine tolerance occurs when the stimulatory effects of caffeine decrease over time due to regular consumption. According to H.P. Ammon from the National Library of Medicine, caffeine tolerance occurs when the body responds to an intake of caffeine through the up-regulation of adenosine-receptors. References


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Atropine can be used to reduce the effect of the poisoning by blocking muscarinic acetylcholine receptors, which would otherwise be overstimulated, by excessive acetylcholine accumulation. Atropine or diphenhydramine can be used to treat muscarine intoxication. Irinotecan induced diarrhea
Atropine has been observed to prevent or treat irinotecan induced acute diarrhea. Side effects
Adverse reactions to atropine include ventricular fibrillation, supraventricular or ventricular tachycardia, dizziness, nausea, blurred vision, loss of balance, dilated pupils, photophobia, dry mouth and potentially extreme confusion, deliriant hallucinations, and excitation especially among the elderly. These latter effects are because atropine is able to cross the blood–brain barrier. Because of the hallucinogenic properties, some have used the drug recreationally, though this is potentially dangerous and often unpleasant.In overdoses, atropine is poisonous. Atropine is sometimes added to potentially addictive drugs, particularly antidiarrhea opioid drugs such as diphenoxylate or difenoxin, wherein the secretion-reducing effects of the atropine can also aid the antidiarrhea effects.Although atropine treats bradycardia (slow heart rate) in emergency settings, it can cause paradoxical heart rate slowing when given at very low doses (i.e. <0.5 mg), presumably as a result of central action in the CNS. One proposed mechanism for atropines paradoxical bradycardia effect at low doses involves blockade of inhibitory presynaptic muscarinic autoreceptors, thereby blocking a system that inhibits the parasympathetic response.Atropine is incapacitating at doses of 10 to 20 mg per person. Its LD50 is estimated to be 453 mg per person (by mouth) with a probit slope of 1.8.