Griffith proposed three ways in which a protein could be a pathogen.In the first hypothesis, he suggested that if the protein is the product of a normally suppressed gene, and introducing the protein could induce the genes expression, that is, wake the dormant gene up, then the result would be a process indistinguishable from replication, as the genes expression would produce the protein, which would then go wake the gene up in other cells. His second hypothesis forms the basis of the modern prion theory, and proposed that an abnormal form of a cellular protein can convert normal proteins of the same type into its abnormal form, thus leading to replication. His third hypothesis proposed that the agent could be an antibody if the antibody was its own target antigen, as such an antibody would result in more and more antibody being produced against itself. However, Griffith acknowledged that this third hypothesis was unlikely to be true due to the lack of a detectable immune response.Francis Crick recognized the potential significance of the Griffith protein-only hypothesis for scrapie propagation in the second edition of his "Central dogma of molecular biology" (1970): While asserting that the flow of sequence information from protein to protein, or from protein to RNA and DNA was "precluded", he noted that Griffiths hypothesis was a potential contradiction (although it was not so promoted by Griffith).
IgA pemphigus is a subtype of pemphigus with two distinct forms:

Subcorneal pustular dermatosis (also known as Sneddon–Wilkinson disease and pustulosis subcornealis) is skin condition that is a rare, chronic, recurrent, pustular eruption characterized histopathologically by subcorneal pustules that contain abundant neutrophils. : 203  This is distinct from and not to be confused with subcorneal pustular dermatosis type of IgA pemphigus. Sneddons syndrome, also known as Ehrmann-Sneddon syndrome, is also a different syndrome. Intraepidermal neutrophilic IgA dermatosis is characterized histologically by intraepidermal bullae with neutrophils, some eosinophils, and acantholysis. : 465

History
Early descriptions were made by Darrell Wilkinson, a British dermatologist. See also
Pemphigus
List of cutaneous conditions
List of conditions caused by problems with junctional proteins
List of immunofluorescence findings for autoimmune bullous conditions

References


== External links ==