References
External links
Acute Lymphocytic Leukemia Archived 16 November 2009 at the Wayback Machine at the American Cancer Society
Childhood ALL Treatment at the National Cancer Institute
The use of the sympathomimetic drug causes the iris dilator muscle to be directly stimulated, causing increased dilation. In the United States, the sympathomimetic drop most commonly used along with tropicamide, is 2.5% phenylephrine hydrochloride (brand name AK-Dilate). Side effects
Tropicamide induces transient stinging and a slight and transient rise in intraocular pressure in the majority of patients. It may cause redness or conjunctivitis (inflammation) and also blurs near vision for a short while after instillation (care must be taken, and the patient must only drive when vision returns to normal). Tropicamide may, in very rare cases, cause an attack of acute angle-closure glaucoma. This tends to be in patients with narrow anterior chamber angles, and closure risk must be assessed by the practitioner prior to instillation. Tropicamide is often preferred to atropine because atropine has a longer half-life, causing prolonged dilation and blurry vision for up to a week. Atropine has less sting effect, but can be toxic or fatal if ingested in large quantities by children or adults. With eye drops, systemic effects are minimal to nonexistent due to very low absorption into the bloodstream. Illicit use
According to the researchers of the European Commission-funded ReDNet Project, in Russia tropicamide is currently abused (injected intravenously) as an inexpensive recreational deliriant drug. Stereochemistry
Tropicamide has a chiral center and two enantiomers. Medications are racemates. References
External links
"Tropicamide". Drug Information Portal. U.S. National Library of Medicine.