Risk factors
Endogenous depression occurs as the results of an internal stressor—commonly cognitive or biological—and not an external factor. Potential risk factors include these cognitive or biological factors. Patients with endogenous depression often are more likely to have a positive family history of disorders and fewer psychosocial and environmental factors that cause their symptoms. A family history of depression and perceived poor intimate relationships are internal risk factors associated with this type of depression. It is important to know these risk factors in order to take steps to recognize and help prevent this illness. Treatment
Clinicians generally favor treatments such as antidepressant and mood-stabilizing medication and electroconvulsive therapy (ECT). ECT is an effective treatment option for endogenous depression. Both medication and ECT can be used in the short-term to treat acute episodes of endogenous depression, and in the long-term to reduce the risk of recurrence. During the first two decades of the 21st century, a new promising alternative/adjunctive depression treatment method known as transcranial magnetic stimulation, or TMS as its more commonly known, has become available. Prevalence
This type of depression often occurs due to biological reasons. Since symptoms are due to an internal phenomena, prevalence rates tend to be higher in older adults and more prevalent among women. Although endogenous depression has been associated with increased age, there have been few attempts to evaluate this fully. More research is needed to indicate factual prevalence rates on this type of depression in society. History
Endogenous depression was initially considered valuable as a means of diagnostic differentiation with reactive depression.
In particular, splenosis is differentiated from different forms of  lymphoma, metastisized cancers, cancer of the abdomen and pleural tissues, primary kidney or liver tumors, endometriosis or non-cancerous swollen lymph nodes. Treatment
Treatment of splenosis is often unnecessary, because it is benign and usually asymptomatic. For people experiencing symptoms, the splenic tissue can be removed by surgery. Epidemiology
Splenosis is slightly more common in males than females, probably due to the greater frequency of physical trauma experienced by men. == References ==