Asperger syndrome (AS), also known as Aspergers, was the name of a neurodevelopmental disorder no longer recognised as a diagnosis in itself, having been merged into autism spectrum disorder (ASD). It was characterized by significant difficulties in social interaction and nonverbal communication, along with restricted and repetitive patterns of behaviour and interests. It was said to differ from other diagnoses that were merged into ASD by relatively unimpaired language and intelligence. The syndrome was named after the Austrian pediatrician Hans Asperger, who, in 1944, described children in his care who struggled to form friendships, did not understand others gestures or feelings, engaged in one-sided conversations about their favourite interests, and were clumsy.The exact cause of Aspergers is poorly understood. While it has high heritability, the underlying genetics have not been determined conclusively. Environmental factors are also believed to play a role. Brain imaging has not identified a common underlying condition.In 1994, the diagnosis of Aspergers was included in the fourth edition (DSM-IV) of the American Diagnostic and Statistical Manual of Mental Disorders; with the publication of DSM-5 in 2013 the diagnosis was removed, and the symptoms are now included within autism spectrum disorder along with classic autism and pervasive developmental disorder not otherwise specified (PDD-NOS).
Oslers nodes are painful, red, raised lesions found on the hands and feet. They are associated with a number of conditions, including infective endocarditis, and are caused by immune complex deposition. Their presence is one definition of Oslers sign. Causes
Oslers nodes result from the deposition of immune complexes. The resulting inflammatory response leads to swelling, redness, and pain that characterize these lesions. The nodes are commonly indicative of subacute bacterial endocarditis. 10–25% of endocarditis patients will have Oslers nodes. Other signs of endocarditis include Roths spots and Janeway lesions. The latter, which also occur on the palms and soles, can be differentiated from Oslers nodes because they are non-tender.Oslers nodes can also be seen in

Systemic lupus erythematosus
Marantic endocarditis
Disseminated gonococcal infection
Distal to infected arterial catheter

Etymology
Oslers nodes are named after Sir William Osler who described them in the early twentieth century. He described them as "ephemeral spots of a painful nodular erythema, chiefly in the skin of the hands and feet." == References ==