In healthy young men, NETA alone at a dose of 5 to 10 mg/day orally for 2 weeks suppressed testosterone levels from ~527 ng/dL to ~231 ng/dL (–56%). Chemistry
NETA, also known as norethinyltestosterone acetate, as well as 17α-ethynyl-19-nortestosterone 17β-acetate or 17α-ethynylestra-4-en-17β-ol-3-one 17β-acetate, is a progestin, or synthetic progestogen, of the 19-nortestosterone group, and a synthetic estrane steroid. It is the C17β acetate ester of norethisterone. NETA is a derivative of testosterone with an ethynyl group at the C17α position, the methyl group at the C19 position removed, and an acetate ester attached at the C17β position. In addition to testosterone, it is a combined derivative of nandrolone (19-nortestosterone) and ethisterone (17α-ethynyltestosterone). Synthesis
Chemical syntheses of NETA have been published. History
Schering AG filed for a patent for NETA in June 1957, and the patent was issued in December 1960. The drug was first marketed, by Parke-Davis as Norlestrin in the United States, in March 1964. This was a combination formulation of 2.5 mg NETA and 50 μg ethinylestradiol and was indicated as an oral contraceptive. Other early brand names of NETA used in oral contraceptives included Minovlar and Anovlar. Society and culture
Generic names
Norethisterone acetate is the INN, BANM, and JAN of NETA while norethindrone acetate is its USAN and USP. Brand names
NETA is marketed under a variety of brand names throughout the world including Primolut-Nor (major), Aygestin (US), Gestakadin, Milligynon, Monogest, Norlutate (US, CA), Primolut N, SH-420 (UK), Sovel, and Styptin among others.
Mietens syndrome is a autosomal recessive disorder first described by Mietens and Weber. The condition is named after a German physician named Carl Mietens.Only 9 cases have been reported. Symptoms and signs
Intellectual disability
Flat feet
Crossed eyes
Severe postnatal growth retardation
Nystagmus
Narrow nose
Short forearm bones
Absent proximal radial epiphyses
Autosomal recessive inheritance
Dislocated radial head
Sclerocornea has been reported in this condition. History
In 1966, Carl Mietens and Helge Weber reported  cases of four children, 3 sisters and 1 brother. Who suffered from a cluster of congenital anomalies and mental retardantion.In 2006, two documented has been reported. == References ==