Adverse effects
Adverse effects of methadone include:
Sedation
Constipation
Flushing
Perspiration
Heat intolerance
Dizziness or fainting
Weakness
Chronic fatigue, sleepiness and exhaustion
Sleep problems such as drowsiness,
Insomnia
Constricted pupils
Dry mouth
Nausea and vomiting
Low blood pressure
Headache
Heart problems such as chest pain or fast/pounding heartbeat
Abnormal heart rhythms
Respiratory problems such as trouble breathing, slow or shallow breathing (hypoventilation), light-headedness, or fainting
weight gain
Memory loss
Itching
Difficulty urinating
Swelling of the hands, arms, feet, and legs
Mood changes, euphoria, disorientation
Blurred vision
Decreased libido, difficulty in reaching orgasm, or impotence
Missed menstrual periods,
Skin rash
Central sleep apnea

Withdrawal symptoms
Physical symptoms

Lightheadedness
Tearing of the eyes
Mydriasis (dilated pupils)
Photophobia (sensitivity to light)
Hyperventilation syndrome (breathing that is too fast/deep)
Runny nose
Yawning
Sneezing
Nausea, vomiting, and diarrhea
Fever
Sweating
Chills
Tremors
Akathisia (restlessness)
Tachycardia (fast heartbeat)
Aches and pains, often in the joints or legs
Elevated pain sensitivity
Blood pressure that is too high (hypertension, may cause a stroke)Cognitive symptoms

Suicidal ideation
Susceptibility to cravings
Depression
Spontaneous orgasm
Prolonged insomnia
Delirium
Auditory hallucinations
Visual hallucinations
Increased perception of odors (olfaction), real or imagined
Marked increase in sex drive
Agitation
Anxiety
Panic disorder
Nervousness
Paranoia
Delusions
Apathy
Anorexia (symptom)Methadone withdrawal symptoms are reported as being significantly more protracted than withdrawal from opioids with shorter half-lives. When used for opioid maintenance therapy, Methadone is generally administered as an oral liquid. Methadone has been implicated in contributing to significant tooth decay. Methadone causes dry mouth, reducing the protective role of saliva in preventing decay. Other putative mechanisms of methadone-related tooth decay include craving for carbohydrates related to opioids, poor dental care, and general decrease in personal hygiene. These factors, combined with sedation, have been linked to the causation of extensive dental damage.
Bodybuilding is suggested for people with symmetrical pectus carinatum. Prognosis
Pectus malformations usually become more severe during adolescent growth years and may worsen throughout adult life. The secondary effects, such as scoliosis and cardiovascular and pulmonary conditions, may worsen with advancing age.Body building exercises (often attempted to cover the defect with pectoral muscles) will not alter the ribs and cartilage of the chest wall, and are generally considered not harmful.Most insurance companies no longer consider chest wall malformations like pectus carinatum to be purely cosmetic conditions. While the psychologic impact of any malformation is real and must be addressed, the physiological concerns must take precedence. The possibility of lifelong cardiopulmonary difficulties is serious enough to warrant a visit to a thoracic surgeon. Epidemiology
Pectus malformations are rare; about 1 in 400 people have a pectus disorder.Pectus carinatum is rarer than pectus excavatum, another pectus disorder, occurring in only about 20% of people with pectus malformations. About four out of five patients are males. See also
Pectus excavatum

References


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