The person may often avoid or undermine pleasurable experiences, be drawn to situations or relationships in which they will suffer, and prevent others from helping them, as indicated by at least five of the following:chooses people and situations that lead to disappointment, failure, or mistreatment even when better options are clearly available
rejects or makes ineffective the attempts of others to help them
following positive personal events (e.g., new achievement), responds with depression, guilt, or a behavior that produces pain (e.g., an accident)
incites angry or rejecting responses from others and then feels hurt, defeated, or humiliated (e.g., makes fun of spouse in public, provoking an angry retort, then feels devastated)
rejects opportunities for pleasure, or is reluctant to acknowledge enjoying themselves (despite having adequate social skills and the capacity for pleasure)
fails to accomplish tasks crucial to their personal objectives despite having demonstrated ability to do so (e.g., helps fellow students write papers, but is unable to write their own)
is uninterested in or rejects people who consistently treat them well
engages in excessive self-sacrifice that is unsolicited by the intended recipients of the sacrifice
The person may often avoid or undermine pleasurable experiences [...][and] rejects opportunities for pleasure, or is reluctant to acknowledge enjoying themself

B) The behaviors in A do not occur exclusively in response to, or in anticipation of, being physically, sexually, or psychologically abused.C) The behaviors in A do not occur only when the person is depressed. Exclusion from DSM-IV
Historically, masochism has been associated with feminine submissiveness.
Pentostatin (or deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer chemotherapeutic drug. Mechanism
It is classified as a purine analog, which is a type of antimetabolite. It mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, interfering with the cells ability to process DNA.Cancer cells generally divide more often than healthy cells; DNA is highly involved in cell division (mitosis) and drugs which target DNA-related processes are therefore more toxic to cancer cells than healthy cells. Uses
Pentostatin is used to treat hairy cell leukemia. It is given by intravenous infusion once every two weeks for three to six months. Additionally, pentostatin has been used to treat steroid-refractory acute and chronic graft-versus-host disease.Pentostatin is also used in chronic lymphocytic leukemia (CLL) patients who have relapsed. == References ==