Pharmacokinetics
Metabolism
Extensive metabolic hepatic metabolism of mometasone furoate to multiple metabolites occurs. No principal metabolites are detectable in plasma. After in vitro incubation, one of the minor metabolites formed is furoate 6β-hydroxymometasone. In human hepatic microsomes, the formation of these metabolites is regulated by CYP3A4. Mometasone
Mometasone by itself is a synthetic, steroidal glucocorticoid or corticosteroid that was never marketed. The C17α furoate ester of mometasone, is the marketed medication. Mometasone furoate acts as a prodrug of mometasone. In addition to its glucocorticoid activity, mometasone also has very potent progestogenic activity and acts as a partial agonist of the mineralocorticoid receptor. Society and culture
Brand names
As of 2016 mometasone furoate was available worldwide in formulations for nasal, oral inhalation, and topical administration, for human and for veterinary use, and in combinations with other drugs, under many brand names.
Combinations
The following combination drugs are available as of 2022:
Mometasone and azelastine as Nasaflex
Mometasone and clotrimazole and gentamicin for veterinary use as Mometamax and Mometavet
Mometasone and clotrimazole and mupirocin as Derma Q
Mometasone and florfenicol and terbinafine for veterinary use as Claro
Mometasone and formoterol as Dulera, Hexaler Bronquial Duo, and Zenhale
Mometasone and fusidic acid as Bactirest-M, Dermotil Fusid, and Momate-F
Mometasone and gentamicin and posaconazole for veterinary use as Mometamax Ultra
Mometasone and hydroquinone and tretinoin as Acnezac-MH
Mometasone and miconazole as Elica M, Elica-M, and Sensicort-F
Mometasone and mupirocin as Sensicort-B
Mometasone and orbifloxacin and posaconazole for veterinary use as Posatex, Posatex voor honden, and Posatex für Hunde
Mometasone and salicylic acid as Cortimax-S, Elicasal, Elocom Plus, Elosalic, Mezo-S, Momate-S, Momesalic, Momtas-S, Monsalic, and Sensicort-S
Mometasone and terbinafine as Cutizone-T, Mezo-T, and MomelomTerbi-Humanity
Mometasone and tiotropium as Tiomom

References
External links
"Mometasone". Drug Information Portal. U.S. National Library of Medicine.