Adverse effects
Common adverse reactions may include nausea and elevated liver enzymes. Serious adverse reactions may include liver problems and low platelets. Transient elevated levels of cardiac troponin‑I were observed in clinical trials; the clinical importance of these findings is not known. However, cardiac toxicity was seen in studies of other animals.As the medication may reduce the platelet count, platelets may need to be checked before the medication is started, then weekly for the first month and every two weeks for the next two months until the level is back to baseline. Liver function should be monitored for three months after administration. Mechanism of action
SMA is a neuromuscular disorder caused by a mutation in the SMN1 gene, which leads to a decrease in SMN protein, a protein necessary for survival of motor neurons. Onasemnogene abeparvovec is a biologic drug consisting of AAV9 virus capsids that contains a SMN1 transgene along with synthetic promoters. Upon administration, the AAV9 viral vector delivers the SMN1 transgene to the affected motor neurons, where it leads to an increase in SMN protein. History
Onasemnogene abeparvovec was developed by the US biotechnology startup AveXis, which was acquired by Novartis in 2018, based on the work at the Institut de Myologie in France.The U.S. Food and Drug Administration (FDA) granted the application for onasemnogene abeparvovec-xioi fast track, breakthrough therapy, priority review, and orphan drug designations.
Halls is a plural of the word hall. Halls may also refer to:

People
Walter Halls (1871–1953), British trade unionist and politician
Ethel May Halls (1882–1967), American actress
Julian Halls (born 1967), British field hockey player
Evelyn Halls (born 1972), Australian fencer
Roxana Halls (born 1974), English artist
Monty Halls (born 1976), British marine biologist and TV presenter
John Halls (born 1982), English footballer, mostly played for Stoke, Brentford and Aldershot, and model
Andy Halls (born 1992), English footballer, has played for Stockport, Macclesfield and Chester
Halls (footballer) (born 1999), Brazilian footballer
Henrique Halls (born 2002), Brazilian footballer

Places
Halls, Georgia, an unincorporated community
Halls, Missouri, an unincorporated community
Halls, Tennessee, a town in West Tennessee
Not to be confused with Halls Crossroads, Tennessee, a suburb of Knoxville sometimes colloquially referred to as "Halls"

Business
Halls (cough drop), a brand of cough drop
Geo. Hall & Sons, a defunct Australian soft drink company
Halls (department store), Kansas City, Missouri, United States