Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine. Other
Chlorpromazine is occasionally used off-label for treatment of severe migraine. It is often, particularly as palliation, used in small doses to reduce nausea by opioid-treated cancer patients and to intensify and prolong the analgesia of the opioids as well. Efficacy has been shown in treatment of symptomatic hypertensive emergency. In Germany, chlorpromazine still carries label indications for insomnia, severe pruritus, and preanesthesia.Chlorpromazine and other phenothiazines have been demonstrated to possess antimicrobial properties, but are not currently used for this purpose except for a very small number of cases. For example, Miki et al. 1992 trialed daily doses of chlorpromazine, reversing chloroquine resistance in Plasmodium chabaudi isolates in mice.Chlorpromazine is an antagonist of several insect monoamine receptors. It is the most active antagonist known of silk moth (Bombyx mori) octopamine receptor α, intermediate for Bm tyramine receptors 1 & 2, weak for Drosophila octopamine receptor β, high for Drosophila tyramine receptor 1, intermediate for migratory locust (Locusta migratoria) tyramine receptor 1, and high for American cockroach (Periplaneta americana) octopamine receptor α and tyramine receptor 1. Adverse effects
There appears to be a dose-dependent risk for seizures with chlorpromazine treatment.
It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats.The use of chlorpromazine in food-producing animals is not permitted in the EU, as a maximum residue limit could not be determined following assessment by the European Medicines Agency. References
External links
"Chlorpromazine". Drug Information Portal. U.S. National Library of Medicine. "Chlorpromazine hydrochloride". Drug Information Portal. U.S. National Library of Medicine.