Use of RNA interference to slow the progression of scrapie has been studied in mice. The RNA blocks production of the protein that the CJD process transforms into prions. Both amphotericin B and doxorubicin have been investigated as treatments for CJD, but as yet there is no strong evidence that either drug is effective in stopping the disease. Further study has been taken with other medical drugs, but none are effective. However, anticonvulsants and anxiolytic agents, such as valproate or a benzodiazepine, may be administered to relieve associated symptoms. Quinacrine, a medicine originally created for malaria, has been evaluated as a treatment for CJD. The efficacy of quinacrine was assessed in a rigorous clinical trial in the UK and the results were published in Lancet Neurology, and concluded that quinacrine had no measurable effect on the clinical course of CJD. Astemizole, a medication approved for human use, has been found to have anti-prion activity and may lead to a treatment for Creutzfeldt–Jakob disease. A monoclonal antibody (code name PRN100) targeting the prion protein (PrP) was given to six people with Creutzfeldt–Jakob disease in an early-stage clinical trial conducted from 2018 to 2022. The treatment appeared to be well-tolerated and was able to access the brain, where it might have helped to clear PrPC.
That is, when the phoneme /h/ precedes a vowel, /h/ may be realized as a voiceless version of the subsequent vowel. For example the word ⟨hit⟩, /hɪt/ is realized as [ɪ̥ɪt]. H is the eighth most frequently used letter in the English language (after S, N, I, O, A, T, and E), with a frequency of about 4.2% in words. When h is placed after certain other consonants, it modifies their pronunciation in various ways, e.g. for ch, gh, ph, sh, and th. Other languages
In the German language, the name of the letter is pronounced /haː/. Following a vowel, it often silently indicates that the vowel is long: In the word erhöhen (heighten), the second ⟨h⟩ is mute for most speakers outside of Switzerland. In 1901, a spelling reform eliminated the silent ⟨h⟩ in nearly all instances of ⟨th⟩ in native German words such as thun (to do) or Thür (door). It has been left unchanged in words derived from Greek, such as Theater (theater) and Thron (throne), which continue to be spelled with ⟨th⟩ even after the last German spelling reform. In Spanish and Portuguese, ⟨h⟩ ("hache" in Spanish, pronounced [atʃe], or agá in Portuguese, pronounced [aˈɣa] or [ɐˈɡa]) is a silent letter with no pronunciation, as in hijo [ˈixo] (son) and húngaro [ˈũɡaɾu] (Hungarian). The spelling reflects an earlier pronunciation of the sound /h/.