One study found that coenzyme Q10 was not reduced as much as with certain other statins (though this is unlikely given the inherent chemistry of the HMG-CoA reductase pathway that all statin drugs inhibit).As opposed to other statins, there is evidence that pitavastatin improves insulin resistance in humans, with insulin resistance assessed by the homeostatic model assessment (HOMA-IR) method.Hyperuricemia or increased levels of serum uric acid have been reported with pitavastatin. Metabolism and interactions
Most statins are metabolised in part by one or more hepatic cytochrome P450 enzymes, leading to an increased potential for drug interactions and problems with certain foods (such as grapefruit juice). The primary metabolism pathway of pitavastatin is glucuronidation. It is minimally metabolized by the CYP450 enzymes CYP2C9 and CYP2C8, but not by CYP3A4 (which is a common source of interactions in other statins). As a result, it is less likely to interact with drugs that are metabolized via CYP3A4, which might be important for elderly patients who need to take multiple medicines. History
Pitavastatin (previously known as itavastatin, itabavastin, nisvastatin, NK-104 or NKS-104) was discovered in Japan by Nissan Chemical Industries and developed further by Kowa Pharmaceuticals, Tokyo. Pitavastatin was approved for use in the United States by the FDA on 08/03/2009 under the trade name Livalo. Pitavastatin has been also approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in UK on 17 August 2010. Zypitamag (pitavastatin magnesium), a pharmaceutical alternative to Livalo, was approved for use in the United States by the FDA in 2017.
Advanced memory is the key "superpower" in savant abilities.Approximately half of savants are autistic; the other half often have some form of central nervous system injury or disease. It is estimated that up to 10% of those with autism have some form of savant abilities. Calendrical savants
A calendrical savant (or calendar savant) is someone who – despite having an intellectual disability – can name the day of the week of a date, or vice versa, on a limited range of decades or certain millennia. The rarity of human calendar calculators is possibly due to the lack of motivation to develop such skills among the general population, although mathematicians have developed formulas that allow them to obtain similar skills. Calendrical savants, on the other hand, may not be prone to invest in socially engaging skills. Mechanism
Psychological
No widely accepted cognitive theory explains savants combination of talent and deficit. It has been suggested that individuals with autism are biased towards detail-focused processing and that this cognitive style predisposes individuals either with or without autism to savant talents. Another hypothesis is that savants hyper-systemize, thereby giving an impression of talent. Hyper-systemizing is an extreme state in the empathizing–systemizing theory that classifies people based on their skills in empathizing with others versus systemizing facts about the external world. Also, the attention to detail of savants is a consequence of enhanced perception or sensory hypersensitivity in these unique individuals.