An inverted nipple (occasionally invaginated nipple) is a condition where the nipple, instead of pointing outward, is retracted into the breast. In some cases, the nipple will be temporarily protruded if stimulated. Both women and men can have inverted nipples. Causes
The most common causes of nipple inversion include:

Born with condition
Trauma which can be caused by conditions such as fat necrosis, scars, or a result of surgery
Breast sagging, drooping or ptosis
Breast cancer
Breast carcinoma
Pagets disease
Inflammatory breast cancer
Breast infections or inflammations
Mammary duct ectasia
Breast abscess
Mastitis
Genetic variant of nipple shape, such as:
Weaver syndrome
Congenital disorder of glycosylation type 1A and 1 L
Kennerknecht-Sorgo-Oberhoffer syndrome
Gynecomastia
Recurrent infections
TuberculosisMost common nipple variations that women are born with are caused by short ducts or a wide areola muscle sphincter. Inverted nipples can also occur after sudden and major weight loss. Grading system
The three grades of inverted nipples are defined on how easily the nipple may be protracted and the degree of fibrosis existent in the breast, as well as the damage it has caused on the milk ducts. Inverted nipple grade 1 refers to nipples that can easily be pulled out, by using finger pressure around the areola. The grade-1 inverted nipple maintains its projections and rarely retracts. Also, grade-1 inverted nipples may occasionally pop up without manipulation or pressure. Milk ducts are usually not compromised and breast feeding is possible. These are "shy nipples". It is believed to have minimal or no fibrosis. There is no soft-tissue deficiency of the nipple.
In 2020, it was the 38th most commonly prescribed medication in the United States, with more than 16 million prescriptions. Medical uses
Ibuprofen is used primarily to treat fever (including post-vaccination fever), mild to moderate pain (including pain relief after surgery), painful menstruation, osteoarthritis, dental pain, headaches, and pain from kidney stones. About 60% of people respond to any nonsteroidal anti-inflammatory drug; those who do not respond well to a particular one may respond to another.It is used for inflammatory diseases such as juvenile idiopathic arthritis and rheumatoid arthritis. It is also used for pericarditis and patent ductus arteriosus.If a patient is self-treating with over-the-counter Ibuprofen, it should not be taken for more than 10 days, unless the patient has spoken with their doctor. Lysine
In some countries, ibuprofen lysine (the lysine salt of ibuprofen, sometimes called "ibuprofen lysinate") is licensed for treatment of the same conditions as ibuprofen; the lysine salt is used because it is more water-soluble.Ibuprofen lysine is sold for rapid pain relief; given in form of a lysine salt, absorption is much quicker (35 minutes compared to 90–120 minutes).