Diagnosis
IF tumors have features which overlap other types of fasciitis disorders such as proliferative fasciitis and nodular fasciitis. However, the age, history of debilitation, tumor location over boney protuberances, and tumor histopathology of having two distinctly different zones tend to distinguish IF from these two as well as the following tumors. Decubitus ulcers, i.e. common bed sores, differ from IF in typically having extensive ulcerations of the skin and histopathological evidence of acute inflammation as determined by the presence of various types of white blood cells. IF has also been mistaken for epithelioid sarcoma and elastofibroma dorsi. IF differs form epithelioid sarcoma by its clinical presentation, typical tumor cell morphology, i.e. round cells with atypical nuclei and eosinophilic cytoplasm, and complete or relative lack of necrotic areas. Elastofibroma dorsi is distinguished from IF by its abundant content of elastic fibers. Treatment
IF tumors are commonly treated by surgical excision although in rare cases these tumors have recurred at the site of their removal. Recurrent tumors have been treated by repeated surgical excisions. Since IF tumors have not been reported to metastasize and no deaths have been attributed to it, long-term clinical observation without surgical intervention is a reasonable alternative to surgery, particularly for IF tumors that are neither uncomfortable, painful, or disfiguring. == References ==
Tetra has two other dronabinol drugs with new routes of administration which limit first-pass metabolism; an inhaled THC-based dronabinol drug and their mucoadhesive-delivery dronabinol drug Adversa®, which are both in the accelerated 505(b)(2) New Drug Application (NDA) pathway for the U.S. and Canadian markets. In the United States, Marinol is a Schedule III drug, available by prescription, considered to be non-narcotic and to have a low risk of physical or mental dependence. Efforts to get cannabis rescheduled as analogous to Marinol have not succeeded thus far, though a 2002 petition has been accepted by the DEA. As a result of the rescheduling of Marinol from Schedule II to Schedule III, refills are now permitted for this substance. Marinols U.S. Food and Drug Administration (FDA) approval for medical use has raised much controversy as to why cannabis is still illegal at the federal level. Comparisons with medical cannabis
Female cannabis plants not only contain dronabinol but at least 113 other cannabinoids, including cannabidiol (CBD), thought to be the major anticonvulsant that helps people with multiple sclerosis; and cannabichromene (CBC), an anti-inflammatory which may contribute to the pain-killing effect of cannabis.It takes over one hour for Marinol to reach full systemic effect, compared to seconds or minutes for smoked or vaporized cannabis.