Society and culture
Generic names
Drospirenone is the generic name of the drug and its INN, USAN, BAN, and JAN, while drospirénone is its DCF. Its name is a shortened form of the name 1,2-dihydrospirorenone or dihydrospirenone. Drospirenone is also known by its developmental code names SH-470 and ZK-30595 (alone), BAY 86-5300, BAY 98-7071, and SH-T-00186D (in combination with ethinylestradiol), BAY 86-4891 (in combination with estradiol), and FSN-013 (in combination with estetrol). Brand names
Drospirenone is marketed in combination with an estrogen under a variety of brand names throughout the world. Among others, it is marketed in combination with ethinylestradiol under the brand names Yasmin and Yaz, in combination with estetrol under the brand name Nextstellis, and in combination with estradiol under the brand name Angeliq. Availability
Drospirenone is marketed widely throughout the world. Generation
Drospirenone has been categorized as a "fourth-generation" progestin. Litigation
Many lawsuits have been filed against Bayer, the manufacturer of drospirenone, due to the higher risk of venous thromboembolism (VTE) that has been observed with combined birth control pills containing drospirenone and certain other progestins relative to the risk with levonorgestrel-containing combined birth control pills.In July 2012, Bayer notified its stockholders that there were more than 12,000 such lawsuits against the company involving Yaz, Yasmin, and other birth control pills with drospirenone.
"Drospirenone Litigation: Does the Punishment Fit the Crime?". J Womens Health (Larchmt). 26 (2): 99–102. doi:10.1089/jwh.2016.6092. PMID 27854556. Bitzer J, Paoletti AM (2009). "Added benefits and user satisfaction with a low-dose oral contraceptive containing drospirenone: results of three multicentre trials". Clin Drug Investig. 29 (2): 73–8. doi:10.2165/0044011-200929020-00001. PMID 19133702. S2CID 10356578. Carranza-Lira S (2009). "Safety, efficacy and patient acceptability of drospirenone and estradiol in the treatment of menopausal vasomotor symptoms: a review". Clin Interv Aging. 4: 59–62. doi:10.2147/CIA.S4117. PMC 2685225. PMID 19503766. Christiansen C (October 2005). "Effects of drospirenone/estrogen combinations on bone metabolism". Climacteric. 8 Suppl 3: 35–41. doi:10.1080/13697130500330283. PMID 16203654. S2CID 42803561. Dickerson V (November 2002). "Quality of life issues. Potential role for an oral contraceptive containing ethinyl estradiol and drospirenone". J Reprod Med. 47 (11 Suppl): 985–93. PMID 12497673. Fenton C, Wellington K, Moen MD, Robinson DM (2007). "Drospirenone/ethinylestradiol 3mg/20microg (24/4 day regimen): a review of its use in contraception, premenstrual dysphoric disorder and moderate acne vulgaris". Drugs. 67 (12): 1749–65. doi:10.2165/00003495-200767120-00007. PMID 17683173. S2CID 46976925. Foidart JM (October 2005). "Added benefits of drospirenone for compliance". Climacteric. 8 Suppl 3: 28–34. doi:10.1080/13697130500330309. PMID 16203653. S2CID 31883491. Foidart JM, Faustmann T (December 2007). "Advances in hormone replacement therapy: weight benefits of drospirenone, a 17alpha-spirolactone-derived progestogen". Gynecol. Endocrinol. 23 (12): 692–9. doi:10.1080/09513590701582323. PMID 18075844. S2CID 12572825. Genazzani AR, Mannella P, Simoncini T (February 2007). "Drospirenone and its antialdosterone properties". Climacteric. 10 Suppl 1: 11–8. doi:10.1080/13697130601114891. PMID 17364593. S2CID 24872884. Han L, Jensen JT (October 2014). "Expert opinion on a flexible extended regimen of drospirenone/ethinyl estradiol contraceptive".