Characteristic Aschoff bodies, composed of swollen eosinophilic collagen surrounded by lymphocytes and macrophages can be seen on light microscopy. The larger macrophages may become Anitschkow cells or Aschoff giant cells. Rheumatic valvular lesions may also involve a cell-mediated immunity reaction as these lesions predominantly contain T-helper cells and macrophages.In rheumatic fever, these lesions can be found in any layer of the heart causing different types of carditis. The inflammation may cause a serofibrinous pericardial exudate described as "bread-and-butter" pericarditis, which usually resolves without sequelae. Involvement of the endocardium typically results in fibrinoid necrosis and wart formation along the lines of closure of the left-sided heart valves. Warty projections arise from the deposition, while subendocardial lesions may induce irregular thickenings called MacCallum plaques. Rheumatic heart disease
Chronic rheumatic heart disease (RHD) is characterized by repeated inflammation with fibrinous repair. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords. It is caused by an autoimmune reaction to Group A β-hemolytic streptococci (GAS) that results in valvular damage. Fibrosis and scarring of valve leaflets, commissures and cusps leads to abnormalities that can result in valve stenosis or regurgitation. The inflammation caused by rheumatic fever, usually during childhood, is referred to as rheumatic valvulitis. About half of patients with rheumatic fever develop inflammation involving valvular endothelium. The majority of morbidity and mortality associated with rheumatic fever is caused by its destructive effects on cardiac valve tissue.
Amok may refer to:

Running amok, the act of behaving disruptively or uncontrollably. Film
Amok (1934 film), a French film
Amok (1944 film), a Mexican romantic drama
Amok (1983 film), a Moroccan drama

Literature
Amok (comics), an Italian comic book series
Amok (novella), by Stefan Zweig, 1922
Amok, a 1974 novel by Harry Thürk
Amok, a 2003 novel by Krystian Bala

Music
Amok (The Late B.P. Helium album), 2004
Amok (Sentenced album), 1995
Amok (Atoms for Peace album), 2013

Other uses
Steamed curry (Khmer: អាម៉ុក, amŏk), name in Cambodia for a curry steam-cooked in banana leaves
Fish amok, a Cambodian steamed fish curry
Amok (video game), a 1996 video game for the Sega Saturn
Mok language, also known as Amok
Amok (publisher), now Frémok, a Franco-Belgian comics publishing house
Amok Press, a defunct American book imprint

See also
All pages with titles beginning with Amok
All pages with titles containing Amok
"Amok Time", a 1967 episode of Star Trek: The Original Series
Amuck!, a 1972 Italian giallo film
AMOC (disambiguation)