: 430

Chemistry
Mirtazapine is a tetracyclic piperazinoazepine; mianserin was developed by the same team of organic chemists and mirtazapine differs from it via addition of a nitrogen atom in one of the rings. : 429  It is a racemic mixture of enantiomers. The (S)-(+)-enantiomer is known as esmirtazapine. Analogues of mirtazapine include mianserin, setiptiline, and aptazapine. Synthesis
A chemical synthesis of mirtazapine has been published. The first step of synthesis is a condensation reaction between the molecule 2-chloro 3-cyanopyridine and the molecule 1-methyl-3-phenylpiperazine. History
Mirtazapine was first synthesized at Organon and published in 1989, was first approved for use in major depressive disorder in the Netherlands in 1994, and was introduced in the United States in 1996 under the brand name Remeron. : 429

Society and culture
Generic names
Mirtazapine is the English and French generic name of the drug and its INN, USAN, USP, BAN, DCF, and JAN. Its generic name in Spanish, Italian and Portuguese is mirtazapina and in German and Swedish is Mirtazapin.
The Journal of Clinical Endocrinology and Metabolism. The Endocrine Society. 85 (5): 2034–41. doi:10.1210/jcem.85.5.6564. ISSN 0021-972X. PMID 10843193. Archived from the original on 6 February 2007. Retrieved 25 February 2007. Rathus, Spencer A.; Jeffery S. Nevid, Lois Fichner-Rathus (2002). Human Sexuality in a World of Diversity. Allyn & Bacon. ISBN 978-0-205-40615-9. OCLC 55502508. Schreiber, Gerhard (2016). Transsexuality in Theology and Neuroscience. Findings, Controversies, and Perspectives (in German). Walter de Gruyter. ISBN 978-3-11-044080-5. OCLC 962412457.
Pepper, Shanti M.; Lorah, Peggy (2008). "Career Issues and Workplace Considerations for the Transsexual Community: Bridging a Gap of Knowledge for Career Counselors and Mental Health Care Providers". The Career Development Quarterly. Wiley. 56 (4): 330–343. doi:10.1002/j.2161-0045.2008.tb00098.x. ISSN 0889-4019. ProQuest 219546491. External links

The International Journal of Transgenderism – The Official Journal of the World Professional Association for Transgender Health (formerly HBIGDA). An archive of IJT Volumes I through V is available, as are several books on transsexualism, including Harry Benjamins The Transsexual Phenomenon