It also has more consistently observed non-genomic antimineralocorticoid effects relative to spironolactone (see membrane mineralocorticoid receptor). Eplerenone differs from spironolactone in its extensive metabolism, with a short half-life and inactive metabolites.Eplerenone seems to be about 50 to 75% as potent as spironolactone as an antimineralocorticoid. Hence, 25 mg/day spironolactone may be equivalent to approximately 50 mg/day eplerenone. Regulatory and Patent History
Eplerenone was patented in 1983 and approved for medical use in the United States in 2002. Eplerenone is currently approved for sale in Canada, the US, EU, Netherlands and Japan. Eplerenone costs an estimated $2.93 per day when treating congestive heart failure and $5.86 per day when treating hypertension. See also
Finerenone
Mexrenone


== References ==
Exfoliation can refer to:

Exfoliation (botany), the loss of leaves (or, in some cases, pieces of bark) from a plant
Exfoliation (cosmetology), a cosmetic technique that aims to remove dead skin from the body and face
Exfoliation (geology), a process resulting in parallel fractures in the surface of rock
Exfoliation corrosion (metallurgy), a severe type of intergranular corrosion
Exfoliation - Intercalation (chemistry), the complete separation of the layers of a material
Exfoliation syndrome, an eye disease

See also
Exfoliative dermatitis, sometimes known as erythroderma, a skin disease process involving redness and scaling of most or all of the sufferers skin, with various causes