Signs and symptoms
Common symptoms present in the different types of leprosy include a runny nose; dry scalp; eye problems; skin lesions; muscle weakness; reddish skin; smooth, shiny, diffuse thickening of facial skin, ear, and hand; loss of sensation in fingers and toes; thickening of peripheral nerves; a flat nose from destruction of nasal cartilage; and changes in phonation and other aspects of speech production. In addition, atrophy of the testes and impotence may occur.Leprosy can affect people in different ways. The average incubation period is five years. People may begin to notice symptoms within the first year or up to 20 years after infection. The first noticeable sign of leprosy is often the development of pale or pink coloured patches of skin that may be insensitive to temperature or pain. Patches of discolored skin are sometimes accompanied or preceded by nerve problems including numbness or tenderness in the hands or feet. Secondary infections (additional bacterial or viral infections) can result in tissue loss, causing fingers and toes to become shortened and deformed, as cartilage is absorbed into the body. A persons immune response differs depending on the form of leprosy.Approximately 30% of people affected with leprosy experience nerve damage. The nerve damage sustained is reversible when treated early, but becomes permanent when appropriate treatment is delayed by several months. Damage to nerves may cause loss of muscle function, leading to paralysis. It may also lead to sensation abnormalities or numbness, which may lead to additional infections, ulcerations, and joint deformities.
Out may refer to:

Arts, entertainment, and media
Films
Out (1957 film), a documentary short about the Hungarian Revolution of 1956
Out (1982 film), an American film directed by Eli Hollander
Out (2002 film), a Japanese film based on the novel by Natsuo Kirino and directed by Hideyuki Hirayama
Out (2013 film), a Canadian short comedy film directed by Jeremy LaLonde
Out (2017 film), a Slovak film directed by György Kristóf
Out (2020 film), an American animated film produced by Pixar

Music
Out (jazz) or outside, an approach to jazz improvisation
OUT, a band produced by Adam Walton
OUT, a 1994 album by Nav Katze
Out (In Essence), a 1991 album by Fluke

Television
Out (miniseries), a 1978 British television crime drama starring Tom Bell
"Out" (Dark Angel), a television episode

Other uses in arts, entertainment, and media
Out (magazine), an LGBT fashion, entertainment, and lifestyle magazine
Out (novel), a 1997 novel by Natsuo Kirino
OUTeverywhere, a community website for LGBT people around the world

Sports and recreation
Out (baseball), a play which retires the batter or a base runner
Out (cricket), the loss of a wicket by a batsman; also known as "dismissal"
Out (poker), an unseen card which is expected to win a hand, if drawn
Out (route), a pattern run by a receiver in American football

Sexuality
Coming out, publicly revealing ones own LGBT status
Outing, publicly revealing someone elses LGBT status

Mathematics
Out(Fn), the outer automorphism group of a free group on n generators
Outer automorphism group, a quotient Out(G) of the automorphism group

Transport
Outwood railway station, West Yorkshire, National Rail station code

Other uses
Out, a procedure word in voice radio communication

See also
Outing (disambiguation)
Outside (disambiguation)
All pages with titles containing Out
All pages with titles beginning with Out