For diabetes insipidus, the effect of thiazide diuretics is presumably mediated by a hypovolemia-induced increase in proximal sodium and water reabsorption, thereby diminishing water delivery to the ADH-sensitive sites in the collecting tubules and increasing the urine osmolality.A low level of evidence, predominantly from observational studies, suggests that thiazide diuretics have a modest beneficial effect on bone mineral density and are associated with a decreased fracture risk when compared with people not taking thiazides. Thiazides decrease mineral bone loss by promoting calcium retention in the kidney, and by directly stimulating osteoblast differentiation and bone mineral formation.The combination of fixed-dose preparation such as losartan/hydrochlorothiazide has added advantages of a more potent antihypertensive effect with additional antihypertensive efficacy at the dose of 100 mg/25 mg when compared to monotherapy. Adverse effects
Hypokalemia, or low blood levels of potassium are an occasional side effect. It can be usually prevented by potassium supplements or by combining hydrochlorothiazide with a potassium-sparing diuretic
Other disturbances in the levels of serum electrolytes, including hypomagnesemia (low magnesium), hyponatremia (low sodium), and hypercalcemia (high calcium)
Hyperuricemia (high levels of uric acid in the blood). All thiazide diuretics including hydrochlorothiazide can inhibit excretion of uric acid by the kidneys, thereby increasing serum concentrations of uric acid.This may increase the incidence of gout in doses of ≥ 25 mg per day and in more susceptible patients such as male gender of <60 years old.
PID or Pid may refer to:

Medicine
Pelvic inflammatory disease or pelvic inflammatory disorder, an infection of the upper part of the female reproductive system
Primary immune deficiency, disorders in which part of the bodys immune system is missing or does not function properly
Prolapsed intervertebral disc, commonly called a herniated disc

Science, technology and engineering
BBC Programme Identifier, a unique identifier for a BBC television or radio programme brand, a season or series, or an individual episode
OBD-II PIDs (on-board diagnostics parameter IDs), requests for data through an OBD connector in automotive repair
Packet Identifier, a field in a MPEG transport stream packet
Passive infrared detector, a passive infrared sensor
Persistent identifier, a long-lasting reference to a document, file, web page, or other object
Phosphotyrosine-interacting domain, also known as phosphotyrosine-binding domain, a protein domain which bind to phosphotyrosine
Photoionization detector, measures volatile organic compounds and other gases
Physical Interface Device, a class of a USB device
PID controller (proportional-integral-derivative controller), a control concept used in automation
Piping and instrumentation diagram (P&ID), a diagram in the process industry which shows the piping of the process flow etc.