Sponastrime dysplasia is a rare condition characterised by facial and skeletal abnormalities. Signs and symptoms
The main features of this condition are evident in skeleton and face.Facial features:

Macrocephaly
Frontal bossing
Midface hypoplasia
Depressed nasal root
Small upturned nose
PrognathismSkeletal features:

Shortened limbs (more pronounced in lower limbs)
Short stature
Progressive coxa varaOn X ray:

Abnormal vertebral bodies (particularly in the lumbar region)
Avascular necrosis of the capital femoral epiphyses
Striated metaphyses
Generalized mild osteoporosis
Delayed ossification of the carpal bonesOther associated conditions:
These are variably present
Cataracts
Hypogammaglobulinemia
Intellectual disability
Short dental roots
Subglottic stenosis
Tracheobronchomalacia

Genetics
This condition has been associated with mutations in the Tonsoku-like, DNA repair protein (TONSL) gene. This gene is located on the long arm of chromosome 8 (8q24.3). This gene is also known as NFKBIL2. Pathopysiology
This is not understood. It appears that the TONSL gene product is involved in genome repair. Diagnosis
This can be suspected when the usual facial and skeletal features are present. It is confirmed by sequencing the TONSL gene. Differential diagnosis
Short limbed dwarfism syndrome in association with immunodeficiency. Treatment
There is no specific treatment for this condition. Management is supportive. Epidemiology
This condition is considered to be rare with less than 100 cases reported in the literature. History
This condition was first described in 1983. == References ==
Acute Interstitial Pneumonitis can result from many different irritants in the lungs and usually is resolved in under a month. Chemical Pneumonitis is caused by toxic substances reaching the lower airways of the bronchial tree. This causes a chemical burn and severe inflammation. (oxford)
Radiation Pneumonitis, also known as Radiation Induced Lung Injury, describes the initial damage done to the lung tissue by ionization radiation. Radiation, used to treat cancer, can cause pneumonitis when applied to the chest or full body. Radiation pneumonitis occurs in approximately 30% of advanced lung cancer patients treated with radiation therapy. Aspiration pneumonitis is caused by a chemical inhalation of harmful gastric contents which include causes such as:
Aspiration due to a drug overdose
A lung injury after the inhalation of habitual gastric contents. The development of colonized oropharyngeal material after inhalation. Bacteria entering the lungs

Treatment
Typical treatment for pneumonitis includes conservative use of corticosteroids such as a short course of oral prednisone or methylprednisolone. Inhaled corticosteroids such as fluticasone or budesonide may also be effective for reducing inflammation and preventing re-inflammation on a chronic level by suppressing inflammatory processes that may be triggered by environmental exposures such as allergens. Severe cases of pneumonitis may require corticosteroids and oxygen therapy, as well as elimination of exposure to known irritants.Corticosteroid dose and treatment duration vary from case to case.