The term acne cosmetica refers to acne caused by or aggravated by cosmetics. : 240   The mechanism is thought to be chemically induced plugging of the pilosebaceous orifice. This became a significant problem for dermatologists in the 1970s and 1980s, but with the improved formulations produced by cosmetic chemists in the decades since, a diagnosis of acne cosmetica has become relatively rare in dermatological practice. The terms "non-comedogenic" and "non-acne(i)genic" appeared on moisturizers and other cosmetic compounds as manufacturers introduced re-formulations—sometimes associated with claims that the products were "oil-free" or "water-based". Although early work produced lists of comedogenic chemicals in various strengths and vehicles, it became apparent that one could not predict the actual comedogenicity of a product from its contents; rather, the finished product itself needed use-testing.The production of a low-grade folliculitis by some components of cosmetic products has led to misdiagnosis on occasion. People may not attribute skin reactions to their cosmetics at first, but may notice worsening symptoms after using certain face makeup, sunblock or lip products. Reactions are more likely to occur if applied cosmetics are left on and not stripped after wearing them. See also
List of cutaneous conditions

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She was noted to have a heart murmur which was then discovered to be caused by a ventricular septal defect (a type of congenital heart defect), but it disappeared on its own few years after the physical examination that discovered said defect (thought to be caused by a spontaneous closure of said defect).The second case was her younger, 4-year-old toddler brother. He was born weighing 3042 grams, and was noted to have cyanosis at birth, which was an indicator for a possible heart anomaly. He learned how to control his head at 3 months of age and learned how to walk when he was 20 months old, at the age of 2 he was found to have a speech delay and could only say a handful of words. Physical examination done on him in July 1984 showed a height of 72.7 cm, a weight of 7.7 km, and a head circumference of 44.5 cm. He had the same skin tone, hair color, and facial characteristics as his proband sister. A systolic ejection murmur (grade 4/6) could be heard at his second left intercostal face, this same murmur was later discovered to be caused by pulmonary valve stenosis. Like his sister, he also had whorls and loops in his fingerprints (4 and 6, respectively), and he had routine laboratory tests and a karyotype which turned back normal. Physical examination done in him again in May 1987 showed a height of 94.3 cm, a weight of 45.2 kg, and a head circumference of 49.7 cm.