The basal layer of the cornea is populated by meroclones and paraclones at the periphery, and only paraclones in the central cornea, reflecting the above process of cell division and differentiation. Holoclones are identified by high expression of the marker p63 and are also known as p63 bright cells. Society and culture
In February 2015, the European Commission approved autologous CLET using the stem cell therapy Holoclar for people with severe LSCD due to corneal burns. This is the first time that a stem cell therapy (other than the use of umbilical cord stem cells) has been approved by any regulatory agency in the world. It was created by Graziella Pellegrini and Michele de Luca. Holoclar is a tissue-engineered product that comprises ex vivo expanded autologous human corneal epithelial cells including stem cells, which replace limbal stem cells in patients where the limbus has been destroyed by ocular burns. The use of p63 transcription factor as a biomarker of potency ensures specified amount of stem cells needed for clinical success. Clinically relevant long-term beneficial results have been documented in the treatment of patients with LSCD due to physical or chemical ocular burns. See also
List of human cell types derived from the germ layers

Figures
References
Further reading
Pellegrini G, Ardigò D, Milazzo G, Iotti G, Guatelli P, Pelosi D, De Luca M (January 2018). "Navigating Market Authorization: The Path Holoclar Took to Become the First Stem Cell Product Approved in the European Union". Stem Cells Transl Med. 7 (1): 146–154. doi:10.1002/sctm.17-0003. PMC 5746151. PMID 29280318.
Cerocorticium molle is a species of crust fungus in the family Meruliaceae. Taxonomy
The fungus was first described by Miles Berkeley and Moses Ashley Curtis in 1868 as Corticium molle. They described the fruit body of the type specimen as resembling "a thin coating of wax poured over the surface". It was transferred to genus Cerocorticium by Walter Jülich in 1975. Habitat and distribution
Cerocorticium molle grows on the dead bark and wood of a variety of angiosperms, and it has occasionally been recorded growing on or under the bark of living trees. It is found in tropical and subtropical regions of Africa, Asia, North America, and South America. == References ==