Cryoglobulinemic vasculitis is a form of inflammation affecting the blood vessels caused by the deposition of abnormal proteins called cryoglobulins in the blood vessels, in patients affected by mixed cryoglobulinemia (type 2 and 3), since simple or type 1 cryoglobulinemia does not cause complement activation (but a hyperviscosity syndrome only). Cryoglobulinemic vasculitis affects the skin and causes a rash in roughly 15% of people with detectable circulating cryoglobulin proteins. : 835  Additionally, the kidneys may be affected by this form of vasculitis resulting in membranoproliferative glomerulonephritis. Fevers, painful muscles and joints, and peripheral nerve damage are other common manifestations of cryoglobulinemic vasculitis. Due to deposition of complement (in particular, C4), low levels of circulating complement factors may be seen. See also
Cryoglobulinemia
Cutaneous small-vessel vasculitis
Skin lesion

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There is a big community of Sayyids settled in and around the Nanganallur region in Chennai that trace their ancestry directly to the Sayyids of Iraq.Traditional Sayyid families rarely marry outside their community, and emphasise marrying into Najeeb Altarfain (of Sayyid descent from both the mothers and fathers side) families. This insistence on endogamy has begun to decline among the more urbanized families, with an increase in exogamy with other groups such as the Shaikh and Mughals.Historically, the Sayyids of Uttar Pradesh were substantial landowners, often absentees, and this was especially the case with the Awadh taluqdars. In the urban townships, Sayyid families served as priests, teachers, and administrators with the British colonial authorities given the community a preference in recruitment. Though they account for less than 3% of Muslim population, they control a majority of economic resources. The community also has a very high literacy rate. The independence and partition of India in 1947 was traumatic for the community, with many families becoming divided and some moving to Pakistan. This was followed by the abolition of the zamindari system, where land was redistributed to those who till the land. Many Sayyids who remained on the land are now medium and small scale farmers, while in urban areas, there has been a shift towards modern occupations.The Sayyids of Punjab belong to the Hasani (descendants of Hasan), Husaini (descendants of Husayn), Zaidi (descendants of Zayd ibn Ali, grandson of Husayn), Rizvi, (descendants of Ali al-Ridha), and Naqvi and their sub-caste Bukhari (descendants of Ali al-Hadi).