Naphazoline/pheniramine, sold under the brand name Naphcon-A among others, is a combination eye drop used to help the symptoms of allergic conjunctivitis such as from hay fever. It contains naphazoline and pheniramine. It is used as an eye drop. Use is not recommended for more than three days.Side effects may include allergic reactions, eye pain, and dilated pupils. It is unclear if use in pregnancy is safe. Nephazoline works by resulting in constriction of blood vessels thus decreasing redness while pheniramine works by blocking the effects of histamine to stop itching.The combination was approved for medical use in the United States in 1994. It is available over the counter. In 2017, it was the 203rd most commonly prescribed medication in the United States, with more than two million prescriptions. Medical use
It is administered topically with one to two drops applied to the affected eye(s) up to four times daily. Adverse effects
Pupils may become enlarged temporarily
Overuse may cause more redness
Those with heart disease, high blood pressure, narrow angle glaucoma or who have urination trouble are discouraged from using the product
It is recommended to remove contact lenses before use. Use with contact lenses can lead to reduced oxygenation of the underlying cornea
If infants or children accidentally ingest the drops, it may lead to coma and significant reduction in body temperature. If such ingestion occurs, immediately calling a poison control center is recommended

References
External links
"Naphazoline hydrochloride mixture with pheniramine maleate". Drug Information Portal. U.S. National Library of Medicine.
Cebocephaly (from Greek kebos, "monkey" + kephale, "head") is a developmental anomaly that is part of a group of defects called holoprosencephaly. Cebocephaly involves the presence of two separate eyes set close together and a small, flat nose with a single nostril (no nasal septum). It may be diagnosed before or after birth. It has a very poor prognosis, with most affected infants dying soon after birth. It is very rare, having been estimated to affect around 1 in 40,000 deliveries. Signs and symptoms
Cebocephaly causes:

two separate eyes set close together
a small, flat nose with a single nostril
ear abnormalities
mouth abnormalities (such as microstomia)The presence of a nasal septum precludes a diagnosis of cebocephaly. Cebocephaly may cause malformations of the sphenoid and ethmoid bones behind the orbit. Cause
Cebocephaly can be caused by many factors, particularly genetic variations. These include 18p-, 14q deletion, 13q deletion, and some vertically transmitted infections. It is part of a group of defects called holoprosencephaly. Diagnosis
Before birth, cebocephaly may sometimes be diagnosed using ultrasound. After birth, cebocephaly is diagnosed based on the characteristic symptoms. A CT scan may be used to confirm the diagnosis. Prognosis
Most infants born with cebocephaly die soon after birth. Epidemiology
Cebocephaly is very uncommon. Some estimates of its prevalence include 1 in 40,000 neonatal deliveries. History
The word "cebocephaly" is derived from Greek kebos (monkey), and kephale (head). See also
Cephalic disorder


== References ==