Prolonged cases are often complicated by the occurrence of long-term problems, such as inflammation of the testicles, joint pains, fatigue, hearing loss, mood and sleep disturbances, muscular pain, abdominal pain, menstrual abnormalities, miscarriages, skin peeling, or hair loss. Inflammation and swelling of the uveal layer of the eye is the most common eye complication in survivors of Ebola virus disease. Eye symptoms, such as light sensitivity, excess tearing, and vision loss have been described.Ebola can stay in some body parts like the eyes, breasts, and testicles after infection. Sexual transmission after recovery has been suspected. If sexual transmission occurs following recovery it is believed to be a rare event. One case of a condition similar to meningitis has been reported many months after recovery, as of October 2015.A study of 44 survivors of the Ebola virus in Sierra Leone reported musculoskeletal pain in 70%, headache in 48%, and eye problems in 14%. Epidemiology
The disease typically occurs in outbreaks in tropical regions of Sub-Saharan Africa. From 1976 (when it was first identified) through 2013, the WHO reported 2,387 confirmed cases with 1,590 overall fatalities. The largest outbreak to date was the Ebola virus epidemic in West Africa, which caused a large number of deaths in Guinea, Sierra Leone, and Liberia. 1976
Sudan
The first known outbreak of EVD was identified only after the fact. It occurred between June and November 1976, in Nzara, South Sudan (then part of Sudan), and was caused by Sudan virus (SUDV). The Sudan outbreak infected 284 people and killed 151.
Warsaw breakage syndrome is a rare genetic condition. Fewer than 10 cases have been reported by 2018. Its clinical manifestations affect several organ systems. Presentation
These include
Severe pre- and postnatal growth retardation
Microcephaly
Intellectual disability
Dysmorphic features
Small and elongated face
Narrow bifrontal diameter
Prominent cheeks
Small nares
Flat philtrum
Relatively large mouth
Bilateral epicanthal folds
High arched palate
Microretrognathism
Coloboma of the optic disc
Strabismus
Cup-shaped ears
Sensorineural deafness
Short neck
Jugular hypoplasia
Cardiac features
Ventricular septal defect
Tetralogy of Fallot
Sketelal features
Clinodactyly of the fifth fingers
Syndactyly of the second and third toes
Small thumbs
Small fibulae
Others
Abnormal skin pigmentation
Single palmar crease

Genetics
This condition is caused by mutations in the DDX11 gene which is located on the short arm of chromosome 12 (12p11). This gene encodes an iron-sulfur containing DNA helicase that belongs to the superfamily 2 of helicases. This protein interacts with the 9-1-1 checkpoint complex protein.The inheritance pattern is not yet clear. Diagnosis
The diagnosis may be suspected on clinical grounds and can be confirmed by sequencing the DDX11 gene. Differential diagnosis
The DDX should be based on the following:
Bloom syndrome
Cornelia de Lange syndrome
Fanconi anemia
Nijmegen breakage syndrome
Roberts syndrome
Xeroderma pigmentosum

Treatment
There is no known curative treatment for this condition presently. Management is supportive. History
This condition was first described in 2010. == References ==