In approximately half of those cases (54% or 89,000), people will die. Under-reporting is a common problem as only 1,300 cases were reported worldwide since 2010, which is less than 1% of the projected incidence based on the modelling. Lack of laboratory diagnostic capabilities and lack of disease awareness amongst health care providers also causes under diagnosis. Even if bacterial cultures show positive result for B. pesudomallei, they can be discarded as contaminants especially in laboratories in non-endemic areas. In 2015, it was estimated that the yearly disability-adjusted life year (DALY) was 84.3 per 100,000 people. As of 2022, melioidosis is not included in the WHO list of neglected tropical diseases. Geography
Melioidosis is endemic in parts  of southeast Asia (including Thailand, Laos, Singapore, Brunei, Malaysia, Myanmar and Vietnam), southern China, Taiwan northern Australia. India, and South America. Since 1991, a total of 583 cases were reported in India. Most Indian cases are located in Karnataka and Tamil Nadu. Fifty-one cases of melioidosis were reported in Bangladesh from 1961–2017. Nonetheless, lack of awareness and resources gives rise to under diagnosis of the disease in the country. The true burden of melioidosis in Africa and Middle East remain unknown due to low amount of data. Several melioidosis cases were reported over the years. Although 24 African countries and three Middle Eastern countries predicted to be endemic with melioidosis, however not a single case was reported from these specific countries.
The channels are transformed into a side channel, which is the difference between the two input channels, and a mid channel, the sum of the two input channels. In place of a mid channel, the left channel or the right channel may be encoded instead, which is sometimes more space efficient.Even though the reference encoder uses a single block size for the whole stream, FLAC allows the block size in samples to vary per block. Compression
The amount of compression is determined by various parameters, including the order of the linear prediction model and the block size. Regardless of the amount of compression, the original data can always be reconstructed perfectly. For users convenience, the reference implementation defines 9 compression levels, which are presets of the more technical parameters to the encoding algorithm. The levels are labeled from 0 to 8, with higher numbers resulting in a higher compression ratio, at the cost of compression speed. The meaning of each compression level varies by implementation.FLAC is optimized for decoding speed at the expense of encoding speed. A benchmark has shown that, while there is little variation in decoding speed as compression level increases, beyond the default compression level 5, the encoding process takes up considerably more time with little space saved compared to level 5. Comparison to other formats
FLAC is specifically designed for efficient packing of audio data, unlike general-purpose lossless algorithms such as DEFLATE, which are used in ZIP and gzip.