A hypotonic-hyporesponsive episode (HHE) is defined as sudden onset of poor muscle tone, reduced consciousness, and pale or bluish skin occurring within 48 hours after vaccination, most commonly pertussis vaccination. An HHE is estimated to occur after 1 in 4,762 to 1 in 1,408 doses of whole cell pertussis vaccine, and after 1 in 14,286 to 1 in 2,778 doses of acellular pertussis vaccine. == References ==
History
Although there were earlier clinical accounts of this disease, and descriptions and illustrations of the posterior columns of the spinal cord, it was the Berlin neurologist Romberg whose account became the classical textbook description, first published in German and later translated into English.Sir Arthur Conan Doyle, author of the Sherlock Holmes stories, completed his doctorate on tabes dorsalis in 1885.

Notable patients
German storywriter E.T.A. Hoffmann appears to have had and died from tabes dorsalis. The French novelist Alphonse Daudet kept a journal of the pain he experienced from this condition which was posthumously published as La Doulou (1930) and translated into English as In the Land of Pain (2002) by Julian Barnes. Poet Charles Baudelaire contracted syphilis in 1839 and resorted to opium to help alleviate the pain of tabes dorsalis ascending his spine. Painter Édouard Manet died of syphilis complications, including tabes dorsalis, in 1883, aged 51. Boxer Charley Mitchell
Meyer Nudelman, the father of author and doctor Sherwin Nuland, who described his fathers condition extensively in his book Lost in America; A Journey with my Father (2003). See also
General paresis of the insane
Category:Deaths from tabes dorsalis

References
tabes_dorsalis at NINDS
An Essay Upon the Vasomotor Changes in Tabes Dorsalis by Arthur Conan Doyle


== External links ==