The batsmen seek to survive as many balls as possible before losing their wicket, without attempting to score many runs and avoiding aggressive shots. Sometimes regarded as boring to watch, and sometimes as producing tense finishes. Batting order
The order in which the batsmen bat, from the openers, through the top order and middle order to the lower order. Beach cricket
An informal form of the game played on beaches, particularly in Australia, New Zealand, Sri Lanka and cricket-playing Caribbean countries. Beamer
A delivery that reaches the batsman above waist height without bouncing. This is illegal and an automatic no-ball. Further sanctions are applied to repeat offences, though the exact rules have changed several times. Since 2019, if the umpire believes that the beamer was dangerous and risked injury to the batsman, they issue a first and final warning to the bowler; a second dangerous delivery results in the bowler being banned from bowling for the remainder of that innings. Beat the bat
When a batsman narrowly avoids touching the ball with the edge of their bat, through good fortune rather than skill. Considered a moral victory for the bowler. The batsman is said to have been beaten. In some cases, this may be expanded to "beaten all ends up". Beehive
A diagram showing where a number of balls, usually from a particular bowler, have passed the batsman. Compare pitch map.
Brincidofovir, sold under the brand name Tembexa, is an antiviral drug used to treat smallpox. Brincidofovir is a prodrug of cidofovir. Conjugated to a lipid, the compound is designed to release cidofovir intracellularly, allowing for higher intracellular and lower plasma concentrations of cidofovir, effectively increasing its activity against dsDNA viruses, as well as oral bioavailability.The most common side effects include diarrhea, nausea, vomiting, and abdominal pain.Brincidofovir was approved for medical use in the United States in June 2021. Medical uses
Brincidofovir is indicated for the treatment of human smallpox disease caused by variola virus. Mechanism of Action
Brincidofovir is a pro-drug that is composed of cidofovir, conjugated with a lipid molecule. The lipid aspect of the molecule takes on the action of endogenous lysopghosphatidyl choline, which then is able to enter cells in the body which are infected with smallpox. Once the infected cell takes in the drug, the drug cleaves to generate cidofovir. Cidofovir is then consequently phosphorylated to yield Cidofovir Diphosphate, which is the active drug.Cidofovir diphosphate arises from two key mechanisms. Firstly, cidofovir diphosphate inhibits the variola viruss DNA-polymerase mediated DNA synthesis.The second mechanism is that the drug acts as an acyclic nucleotide and incorporates itself into the viral DNA chain, which then stops viral DNA synthesis. Pharmacokinetics
The oral bioavailability of Brincidofovir is 13.4% as a tablet and 16.8% in a suspension.