It is generally agreed that Wernicke encephalopathy results from severe acute deficiency of thiamine (vitamin B1), whilst Korsakoffs psychosis is a chronic neurologic sequela of Wernicke encephalopathy. The metabolically active form of thiamine is thiamine pyrophosphate, which plays a major role as a cofactor or coenzyme in glucose metabolism. The enzymes that are dependent on thiamine pyrophosphate are associated with the citric acid cycle (also known as the Krebs cycle), and catalyze the oxidation of pyruvate, α-ketoglutarate and branched chain amino acids. Thus, anything that encourages glucose metabolism will exacerbate an existing clinical or sub-clinical thiamine deficiency.As stated above, Wernicke–Korsakoff syndrome in the United States is usually found in malnourished chronic alcoholics, though it is also found in patients who undergo prolonged intravenous (IV) therapy without vitamin B1 supplementation, gastric stapling, intensive care unit (ICU) stays, hunger strikes, or people with eating disorders. In some regions, physicians have observed thiamine deficiency brought about by severe malnutrition, particularly in diets consisting mainly of polished rice, which is thiamine-deficient. The resulting nervous system ailment is called beriberi. In individuals with sub-clinical thiamine deficiency, a large dose of glucose (either as sweet food, etc. or glucose infusion) can precipitate the onset of overt encephalopathy.Wernicke–Korsakoff syndrome in people with chronic alcohol use particularly is associated with atrophy/infarction of specific regions of the brain, especially the mammillary bodies.
Glossy production is met midway by a startling, intimate style of songwriting, half Youth Lagoon, half something grander and more orchestral.Several tracks from the EP have been licensed to festival-featured European cinema, and Canadian television series Saving Hope. Display EP (2014)
Display was released in June 2014. The lead single Emanate received 250,000 plays across YouTube and Soundcloud in the first two weeks. Volition (2016)
Volition was released in June 2016 following several delays. It received positive reviews across the critical sphere, with The 405 describing the album as gigantic...[yet] effortlessly intimate, praising the cohesion in sound and vision. Ben Yung of therevue.ca gave a glowing review, stating: Volition is stunning, an absolute emotional roller coaster from start to finish. It is easy to understand why it took two years for the Brighton-based five-piece to complete their debut, as every single detail has been given the utmost attention and the production is refined and masterful. Every note, every vocal component, every lyric, every instrumental texture has been attended to and nothing feels out of place. With the precision of a surgeon and the steely aim of an assassin, Phoria hits every mark, including piercing a hole through our hearts with their visceral and emotional electronica. The album was supported by festival appearances throughout 2016 and a UK and European tour. In 2018, the song "Evolve" was featured in an episode of the Syfy original show, The Magicians. Tim Douglas left the band in 2019 citing personal reasons.