Research
Experimentally, recombinant vesicular stomatitis Indiana virus (VSIV) expressing the glycoprotein of MARV has been used successfully in nonhuman primate models as post-exposure prophylaxis. A vaccine candidate has been effective in nonhuman primates. Experimental therapeutic regimens relying on antisense technology have shown promise, with phosphorodiamidate morpholino oligomers (PMOs) targeting the MARV genome  New therapies from Sarepta and Tekmira  have also been successfully used in humans as well as primates. See also
List of other Filoviridae outbreaks

References
Further reading
External links

ViralZone: Marburg virus
Centers for Disease Control, Infection Control for Viral Haemorrhagic Fevers In the African Health Care Setting. Center for Disease Control, Marburg Haemorrhagic Fever. Center for Disease Control, Known Cases and Outbreaks of Marburg Haemorrhagic Fever
Ebola and Marburg haemorrhagic fever (10 July 2008) factsheet from European Centre for Disease Prevention and Control
World Health Organization, Marburg Haemorrhagic Fever. Red Cross PDF
Virus Pathogen Database and Analysis Resource (ViPR): Filoviridae
Possible reasons for predisposition to VALI include:

An injured lung may be at risk for further injury
Cyclic atelectasis is particularly common in an injured lung

Pathogenesis
Overdistension of alveoli and cyclic atelectasis (atelectotrauma) are the primary causes for alveolar injury during positive pressure mechanical ventilation. Severe injury to alveoli causes swelling of the tissues (edema) in the lungs, bleeding of the alveoli, loss of surfactant (decrease in lung compliance) and complete alveoli collapse (biotrauma). High flow rates are associated with rheotrauma, high volumes with volutrauma and pressures with barotrauma. Collectively these may be converted into a single unit of mechanical power. Diagnosis
VALI does not need to be distinguished from progressive ALI/ARDS because management is the same in both. Additionally, definitive diagnosis of VALI may not be possible because of lack of sign or symptoms. Prevention
Preventing alveolar overdistension
Alveolar overdistension is mitigated by using small tidal volumes, maintaining a low plateau pressure, and most effectively by using volume-limited ventilation. A 2018 systematic review by The Cochrane Collaboration provided evidence that low tidal volume ventilation reduced post operative pneumonia and reduced the requirement for both invasive and non invasive ventilation after surgery

Preventing cyclic atelectasis (atelectotrauma)
Applied positive end-expiratory pressure (PEEP) is the principal method used to keep the alveoli open and lessen cyclic atelectasis. Open lung ventilation
Open lung ventilation is a ventilatory strategy that combines small tidal volumes (to lessen alveolar overdistension) and an applied PEEP above the low inflection point on the pressure-volume curve (to lessen cyclic atelectasis).