DST is capable of determining how well four primary antitubercular drugs inhibit the growth of Mycobacterium Tuberculosis. The four primary antitubercular drugs are Isoniazid, Rifampin, Ethambutol and Pyrazinamide. Drug Susceptibility testing is done by making a Lowenstein-Jensen medium plate and spreading the bacteria on the plate. Disks containing one of the four primary drugs are added to the plate. After weeks of allowing the bacteria to grow the plate is checked for clear areas around the disk. If there is a clear area, the drug has killed the bacteria and most likely the bacteria are not resistant to that drug.As Mycobacterium tuberculosis evolved new strains of resistant bacteria were being found such as XDR-TB. The problem was that primary DST was not suitable for testing bacteria strains that were extensively drug resistant. This problem was starting to be fixed when drug susceptibility tests started including not just the four primary drugs, but secondary drugs. This secondary test is known as Bactec MGIT 960 System. Although Bactec MGIT 960 System was accurate it was still slow at determining the level of resistance.Diagnosis of MDR and XDR-TB in children is challenging. With an increasing number of cases being reported worldwide there is a great need for better diagnostic tools available for pediatric patients.In recent years drug resistant tuberculosis testing has shown a lot of progress. Some studies have found an in-house assay that could rapidly detect resistance to drugs involved in the definition of XDR-TB directly from smear-positive specimens.
Keratoderma is a hornlike skin condition. Classification
The keratodermas are classified into the following subgroups:: 506

Congenital
Simple keratodermas
Diffuse palmoplantar keratodermas
Diffuse epidermolytic palmoplantar keratoderma
Diffuse nonepidermolytic palmoplantar keratoderma
mal de Meleda
Focal palmoplantar keratoderma
Striate palmoplantar keratoderma
Punctate palmoplantar keratoderma
Keratosis punctata palmaris et plantaris
Spiny keratoderma
Focal acral hyperkeratosis
Complex keratodermas
Diffuse palmoplantar keratoderma
Erythrokeratodermia variabilis
Palmoplantar keratoderma of Sybert
Olmsted syndrome
Naegeli–Franceschetti–Jadassohn syndrome
Focal palmoplantar keratoderma
Papillon–Lefèvre syndrome
Pachyonychia congenita type I
Pachyonychia congenita type II
Focal palmoplantar keratoderma with oral mucosal hyperkeratosis
Camisa disease
Ectodermal dysplasias
Cloustons hidrotic ectodermal dysplasia
Acrokeratotic poikiloderma
Dermatopathic pigmentosa reticularis
Syndromic keratodermas
Vohwinkel syndrome
Palmoplantar keratoderma associated with esophageal cancer
Palmoplantar keratoderma and spastic paraplegia
Naxos disease
Striate palmoplantar keratoderma, woolly hair, and left ventricular dilated cardiomyopathy
Keratitis-ichthyosis-deafness syndrome
Corneodermatosseous syndrome
Huriez syndrome
Oculocutaneous tyrosinemia
Cardiofaciocutaneous syndrome
Schöpf–Schulz–Passarge syndrome

Acquired
Acquired keratodermas
AIDS-associated keratoderma
Arsenical keratoses
Calluses
Climacteric keratoderma
Clavi (Corns)
Eczema
Human papillomavirus
Keratoderma blenorrhagicum
Lichen planus
Norwegian scabies
Paraneoplastic keratoderma
Psoriasis
Reactive arthritis
Secondary syphilis
Tinea pedis
Sézary syndrome
Tuberculosis verrucosa cutis
Drug-induced keratoderma

See also
Palmoplantar keratoderma
Skin lesion
List of cutaneous conditions
List of conditions caused by problems with junctional proteins

References


== External links ==