When Loki, god of mischief and strife, murdered Baldr, god of beauty and light, he was punished by being bound in a cave with a poisonous serpent placed above his head dripping venom. Lokis wife Sigyn stood by him with a bowl to catch the poison, but whenever she had to empty the bowl the poison dripped on Lokis face, forcing him to jerk his head away and thrash against his bonds, which caused the earth to tremble.In Greek mythology, Poseidon was the cause and god of earthquakes. When he was in a bad mood, he struck the ground with a trident, causing earthquakes and other calamities. He also used earthquakes to punish and inflict fear upon people as revenge.In Japanese mythology, Namazu (鯰) is a giant catfish who causes earthquakes. Namazu lives in the mud beneath the earth and is guarded by the god Kashima who restrains the fish with a stone. When Kashima lets his guard fall, Namazu thrashes about, causing violent earthquakes. In popular culture
In modern popular culture, the portrayal of earthquakes is shaped by the memory of great cities laid waste, such as Kobe in 1995 or San Francisco in 1906. Fictional earthquakes tend to strike suddenly and without warning. For this reason, stories about earthquakes generally begin with the disaster and focus on its immediate aftermath, as in Short Walk to Daylight (1972), The Ragged Edge (1968) or Aftershock: Earthquake in New York (1999).
Tiagabine (trade name Gabitril) is an anticonvulsant medication produced by Cephalon that is used in the treatment of epilepsy. The drug is also used off-label in the treatment of anxiety disorders and panic disorder. Medical uses
Tiagabine is approved by U.S. Food and Drug Administration (FDA) as an adjunctive treatment for partial seizures in individuals of age 12 and up. It may also be prescribed off-label by physicians to treat anxiety disorders and panic disorder as well as neuropathic pain (including fibromyalgia). For anxiety and neuropathic pain, tiagabine is used primarily to augment other treatments. Tiagabine may be used alongside selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, or benzodiazepines for anxiety, or antidepressants, gabapentin, other anticonvulsants, or opioids for neuropathic pain. It is effective as monotherapy and combination therapy with other antiepileptic drugs in the treatment of partial seizure.The American Academy of Sleep Medicines 2017 clinical practice guidelines recommended against the use of tiagabine in the treatment of insomnia due to poor effectiveness and very low quality of evidence. Side effects
Side effects of tiagabine are dose related. The most common side effect of tiagabine is dizziness. Other side effects that have been observed with a rate of statistical significance relative to placebo include asthenia, somnolence, nervousness, memory impairment, tremor, headache, diarrhea, and depression. Adverse effects such as confusion, aphasia (difficulty speaking clearly)/stuttering, and paresthesia (a tingling sensation in the bodys extremities, particularly the hands and fingers) may occur at higher dosages of the drug (e.g., over 8 mg/day).