Loss of the skin leaves patients vulnerable to infections from fungi and bacteria, and can result in sepsis, the leading cause of death in the disease. Death is caused either by infection or by respiratory distress which is either due to pneumonia or damage to the linings of the airway. Microscopic analysis of tissue (especially the degree of dermal mononuclear inflammation and the degree of inflammation in general) can play a role in determining the prognosis of individual cases. Severity score
The "Severity of Illness Score for Toxic Epidermal Necrolysis" (SCORTEN) is a scoring system developed to assess the severity of TEN and predict mortality in patients with acute TEN.One point is given for each of the following factors:
age >40
heart rate >120 beats/minute
carrying diagnosis of cancer
separation of epidermis on more than ten percent of body surface area (BSA) on day 1. Blood Urea Nitrogen >28 mg/dL
Glucose >252 mg/dL (14 mmol/L)
Bicarbonate <20mEq/L

Score
0–1: 3.2% mortality
2: 12.2% mortality
3: 35.3% mortality
4: 58.3% mortality
≥5: 90% mortalityOf note, this scoring system is most valuable when used on the first and third day of hospitalization, and it may underestimate mortality in patients with respiratory symptoms. References
External links

18-203e. at Merck Manual of Diagnosis and Therapy Home Edition
DermNetNZ
Macrodontia may refer to:

Macrodontia (tooth), a tooth disorder where the teeth are larger than normal
Macrodontia (beetle), a genus of beetles

See also
Macrodonta (disambiguation)