Understanding the biology of the LCMV model virus will help in advancing the understanding of this important class of viruses and more specifically will give insight into the biology of the Lassa virus which proves to be a growing threat around the world. Furthermore, the United States National Institute for Allergy and Infectious Diseases (NIAID) has appointed the family of arenaviridae to be "Category A Priority Pathogens". This translates to the highest level of importance for the high potential for morbidity and mortality from an infectious agent which is relatively easy to produce and transmit. Footnotes
References
ICTVdB-The Universal Virus Database, version 4. [2]
Centers for Disease Control and Prevention. Lymphocytic Choriomeningitis Fact Sheet
CBWInfo (1999). "Safety Precautions for Lymphocytic Choriomeningitis Casualties". Archived from the original on 14 May 2006. Retrieved 11 May 2006. "Rodent virus now linked to six deaths—PetSmart in Rhode Island testing animals for rare disease". NBC News. Microsoft. Associated Press. 25 May 2005. Retrieved 11 May 2006. "Australian scientists discover new virus". The Age. Fairfax. Australian Associated Press. 22 April 2007. Retrieved 22 April 2007. Marrie TJ, Saron MF (January 1998). "Seroprevalence of lymphocytic choriomeningitis virus in Nova Scotia". Am. J. Trop. Med. Hyg. 58 (1): 47–9. doi:10.4269/ajtmh.1998.58.47. PMID 9452291. Bauers, Sandy. "House vs. Mouse: The Latest Ideas in Humanely Showing Our Disease-Ridden Fall Visitors the Door." Philadelphia Inquirer 10 Nov. 2006: n.p. Web. "choriomeningitis." The American Heritage Medical Dictionary. 2009. Web. Craighead, John E. MD. Pathology and Pathogenesis of Human Viral Disease. San Diego, California: Academic, 2000. Print. Lasker, Jill S. "Lymphocytic choriomeningitis."
Accommodative insufficiency (AI) involves the inability of the eye to focus properly on an object. Accommodation is the adjustment of the curvature of the lens to focus on objects near and far. In this condition, amplitude of accommodation of a person is lesser compared to physiological limits for his age. AI is generally considered separate from presbyopia, but mechanically both conditions represent a difficulty engaging the near vision system (accommodation) to see near objects clearly. Presbyopia is physiological insufficiency of accommodation due to age related changes in lens (decreased elasticity and increased hardness) and ciliary muscle power.AI is commonly present in people with convergence insufficiency. Categories
Accommodative insufficiency is further categorised into different categories. Ill-sustained accommodation
Ill-sustained accommodation is a type of accommodative insufficiency in which, range of accommodation will be normal, but after excessive near work accommodative power will decrease. Paralysis of accommodation
In paralysis of accommodation, amplitude of accommodation is either markedly reduced or completely absent (cycloplegia). It may occur due to ciliary muscle paralysis or oculomotor nerve paralysis. Parasypatholytic drugs like atropine will also cause paralysis of accommodation. Unequal accommodation
If there is amplitude of accommodation between the eyes differ 0.5 dioptre or more, it is considered as unequal. Organic diseases, head trauma or functional amblyopia may be responsible for unequal accommodation. Causes
Premature sclerosis of lens or ciliary muscle weaknesses due to systemic or local cases may cause accommodative insufficiency. Systemic causes of ciliary muscle weakness include diabetes, pregnancy, stress, malnutrition etc. Open angle glaucoma, Iridocyclitis etc. are known local causes.