Increased levels of CRP as measured by a CRP test or the more sensitive high serum CRP (hsCRP) test have a close correlation to increased risk of silent stroke. Interleukin-6 is an interleukin (type of protein) produced by T-cells (specialized white blood cells), macrophages and endothelial cells. IL6 is also classified as a cytokine (acts in relaying information between cells). IL6 is involved in the regulation of the acute phase response to injury and infection may act as both an anti-inflammatory agent and a pro-inflammatory. Increased levels of CRP as measured by a CRP test or the more sensitive high serum CRP (hsCRP) test and elevated levels of I6 as measured by an IL6 ELISA are markers for the increased risk of silent stroke. Diabetes mellitus: untreated or improperly managed diabetes mellitus is associated with an increased risk for silent stroke. Hypertension: which affects up to 50 million people in the United States alone is the major treatable risk factor associated with silent strokes. Homocysteine: elevated levels of total homocysteine (tHcy) an amino acid are an independent risk factor for silent stroke, even in healthy middle-aged adults. Metabolic syndrome (MetS):Metabolic syndrome is a name for a group of risk factors that occur together and increase the risk for coronary artery disease, stroke, and type 2 diabetes. A higher number of these MetS risk factors the greater the chance of having a silent stroke.Polycystic ovary syndrome (PCOS): is associated with double the risk for arterial disease including silent stroke independent of the subjects Body mass index (BMI).
Hand-foot syndrome (Palmar-plantar erythrodysesthesia or PPE) -skin rash, swelling, redness, pain and/or peeling of the skin on the palms of hands and soles of feet
Stomach ulcers (This is seen more with the intra-arterial infusion). Contact your health provider immediately
Fever of 100.4 °F (38 °C) or higher, chills (possible signs of infection). Contact your health provider
Diarrhea (2 episodes in a 24-hour period)
Nausea (interferes with ability to eat and unrelieved with prescribed medication)
Vomiting (vomiting more than 4–5 times in a 24-hour period)
Mouth sores (painful redness, swelling or ulcers)
Unusual bleeding or bruising
Black or tarry stools, or blood in your stools
Blood in the urine
Yellowing of the skin or eyes
Tingling or burning, redness, swelling of the palms of the hands or soles of feet

Other
Fertility for both men and women may be affected by floxuridine. Use in research
Apart from its use in chemotherapy, floxuridine is also used in aging research employing a C. elegans model, namely to stop growth and to prevent reproduction. The latter is brought about by treatment of larvae close to maturity with low doses of floxuridine that, even though allowing normal maturation, causes reproducing individuals to lay eggs that are unable to hatch. This limits the population to a single generation allowing quantification of aging processes and measurement of longevity. It has, however, been indicated that floxuridin exposure by itself increases life expectancy potentially leading to flawed data in respective studies. History
Floxuridine first gained FDA approval in December 1970 under the brand name FUDR.