Heavy chain disease
The four heavy chain diseases are exceedingly rare conditions associated with the production, circulation in blood, and often presence in urine of  a free clonal heavy chain with no detected clonal light chains. The heavy chain is non-functional and altered by having deletions, insertions, and point mutations due to somatic mutations in their respective coding genes. Beyond this commonality, however, these diseases have very different clinical differences. Furthermore, each of the heavy chain diseases appears to be due to rare variants of lymphoma and therefore is sometimes regarded as a B cell dyscrasia However, heavy chain diseases are still often classified with plasma cell dyscrasias. The heavy chain diseases are classified as α, γ, and μ heavy chain diseases and are based respectively on >400, 130, and 30-40 case reports as reviewed in a 2014 publication. α Heavy chain disease
α Heavy chain disease (also termed immunoproliferative small intestinal disease or IPSID, Mediterranean lymphoma, and Seligmann disease) afflicts primarily individuals of  Mediterranean, North African, and Middle Eastern descent of lower economic status. Many cases are centered in the Middle East and associated with relatively unsanitary living conditions. The disease usually appears between the ages 10 and 30 and in some cases may be an aberrant immune response to a parasite or other microorganism. The disease commonly effects the gastrointestinal tract leading to signs and symptoms of a malabsorption syndrome or, far less commonly, the respiratory tract with signs and symptoms of respiratory dysfunction.
Tinea faciei is a fungal infection of the skin of the face. It generally appears as a photosensitive painless red rash with small bumps and a raised edge appearing to grow outwards, usually over eyebrows or one side of the face. It may feel wet or have some crusting, and overlying hairs may fall out easily. There may be a mild itch. Treatment
Most infections can be treated with topical antifungal medication. Rarely, more extensive or long-standing infections may require treatment with oral antifungals. The infection will still be contagious between 24 and 48 hours of the first treatment. The ringworm should go away within 4–6 weeks after using effective treatment. See also
Tinea corporis
Antifungal drug
List of cutaneous conditions

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