The first six grades of the scale, grades 1 through 6, are differentiated by the degree of genital masculinization; grade 1 is indicated when the external genitalia is fully masculinized, grade 6 is indicated when the external genitalia is fully feminized, and grades 2 through 5 quantify four degrees of decreasingly masculinized genitalia that lie in the interim. Grade 7 is indistinguishable from grade 6 until puberty, and is thereafter differentiated by the presence of secondary terminal hair; grade 6 is indicated when secondary terminal hair is present, whereas grade 7 is indicated when it is absent. The Quigley scale can be used in conjunction with the traditional three classes of AIS to provide additional information regarding the degree of genital masculinization, and is particularly useful when the diagnosis is PAIS. Complete AIS
Partial AIS
Mild AIS
Management
Management of AIS is currently limited to symptomatic management; no method is currently available to correct the malfunctioning androgen receptor proteins produced by AR gene mutations. Areas of management include sex assignment, genitoplasty, gonadectomy in relation to tumor risk, hormone replacement therapy, genetic counseling, and psychological counseling. CAIS
PAIS
MAIS
Epidemiology
AIS represents about 15% to 20% of DSDs and affects 1 in 20,000 to 1 in 64,000 males.Estimates for the incidence of androgen insensitivity syndrome are based on a relatively small population size, thus are known to be imprecise. CAIS is estimated to occur in one of every 20,400 46,XY births.
The character, Lauren Cooper, played by Bailey De Young, was the first intersex series regular on American television.In season 8, episode 11 ("Delko for the Defense") of the TV series CSI: Miami, the primary suspect has AIS which gets him off a rape charge.In series 8, episode 5 of Call the Midwife, a woman discovers that she has AIS. She attends a cervical smear and brings up that she has never had a period, and is concerned about having children as she is about to be married. She is then diagnosed with "testicular feminisation syndrome", the old term for AIS. People with AIS
Kitty Anderson (activist)
Eden Atwood
Bonnie Hart
Phoebe Hart
Maria José Martínez-Patiño
Hanne Gaby Odiele
Santhi Soundarajan
Miriam van der Have
Kimberly Zieselman

People with Complete androgen insensitivity syndrome
Georgiann Davis
Seven Graham

People with Partial androgen insensitivity syndrome
Tony Briffa
Favorinus of Arelate has been described as having partial androgen insensitivity syndrome. Small Luk
Eliana Rubashkyn
Sean Saifa Wall
Sogto Ochirov

See also
Estrogen insensitivity syndrome
Spinal and bulbar muscular atrophy
Congenital adrenal hyperplasia
5α-Reductase 2 deficiency

References
External links
Information
Androgen Insensitivity Syndrome at NIH/UW GeneTests
Online Mendelian Inheritance in Man (OMIM): Androgen Insensitivity Syndrome - 300068, 313700