An interpretation of this result and what a closer look at the physical meaning of the 
  
    
      
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   one can read the paper by Marcus.the situation at hand can be more accurately described by using the displaced harmonic oscillator model, in this model quantum tunneling is allowed. This is needed in order to explain why even at near-zero Kelvin there still are electron transfers, in contradiction to the classical theory. Without going into too much detail on how the derivation is done, it rests on using Fermis golden rule from time-dependent perturbation theory with the full Hamiltonian of the system. It is possible to look at the overlap in the wavefunctions of both the reactants and the products (the right and the left side of the chemical reaction) and therefore when their energies are the same and allow for electron transfer. As touched on before this must happen because only then conservation of energy is abided by.
The study is ongoing and preliminary results have been published in the New England Journal of Medicine.The full analysis of the COMET-ICE trial was published in JAMA and it showed that sotrovimab reduced risk of hospitalization for more than 24 hours or death by 79% compared to placebo (1% for sotrovoimab group and 6% for the placebo group). The trial involved 1057 participants and took place before the omicron variant was prevalent. Manufacturing
Sotrovimab is a biologic product which takes six months to manufacture in living cells. It is produced in Chinese hamster ovary cells. At product launch in May 2021, sotrovimabs active pharmaceutical ingredient was produced by WuXi Biologics in China and sent to a GlaxoSmithKline plant in Parma, Italy for further processing into the finished product. In January 2022, the spread of the SARS-CoV-2 Omicron variant began to render other monoclonal antibodies obsolete and caused global demand for sotrovimab to skyrocket. In response, Vir and GlaxoSmithKline announced they were working with Samsung Biologics on manufacturing sotrovimab at an additional site in South Korea. Society and culture
Economics
In 2021, the United States government agreed to purchase 1.5 million doses of the drug at $2,100 per dose. Legal status
In May 2021, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) completed its review on the use of sotrovimab for the treatment of COVID-19.