In 2020, it was the eighteenth most commonly prescribed medication in the United States, with more than 28 million prescriptions. It is on the World Health Organizations List of Essential Medicines. Medical uses
Depression
The evidence overall supports the efficacy of bupropion over placebo for the treatment of depression. However, the quality of evidence is low. Most meta-analyses report that bupropion has an at-most small effect size for depression. On the other hand, one meta-analysis reported a large effect size. However, there were methodological limitations with this meta-analysis, including using a subset of only five trials for the effect size calculation, substantial variability in effect sizes between the selected trials—which led the authors to state that their findings in this area should be interpreted with "extreme caution"—and general lack of inclusion of unpublished trials in the meta-analysis. Unpublished trials are more likely to be negative in findings, and other meta-analyses have included unpublished trials. Evidence suggests that the efficacy of bupropion for depression is similar to that of other antidepressants.Over the fall and winter months, bupropion prevents development of depression in those who have recurring seasonal affective disorder: 15% of participants on bupropion experienced a major depressive episode vs. 27% of those on placebo.
In 2013 and 2014, the partners won orphan drug designation in the US for isavuconazonium for treating invasive aspergillosis, mucormycosis, and invasive candidiasis.In 2014, Basilea and Astellas amended the agreement to give Astellas sole marketing authority in North America, and Basilea the rights to market in the rest of the world.The U.S. Food and Drug Administration (FDA) granted approval in March 2015, and the European Medicines Agency (EMA) approved it in October 2015.In 2017, Basilea licensed rights to Pfizer to market isavuconazole in Europe and other regions. References
External links
"Isavuconazonium". Drug Information Portal. U.S. National Library of Medicine. "Isavuconazonium sulfate". Drug Information Portal. U.S. National Library of Medicine. "Isavuconazole". Drug Information Portal. U.S. National Library of Medicine.