Tobramycin passes the placenta: in the fetus, 20% of the mothers concentrations have been measured.The substance is neither bound to plasma proteins, nor is it metabolized. It is excreted in unchanged form via the kidneys with a biological half-life of about 2 to 3 hours. Elimination from deep compartments such as the renal cortex follows after 8 to 12 hours. In newborns the half-life is 4.6 hours on average; in those with a low birth weight it is as long as 8.7 hours on average. People with reduced kidney function also have a longer half-life for tobramycin, while in those with severe burns it can be shorter. References
Further reading
Davis BD (September 1987). "Mechanism of bactericidal action of aminoglycosides". Microbiological Reviews. 51 (3): 341–50. doi:10.1128/MMBR.51.3.341-350.1987. PMC 373115. PMID 3312985. External links
"Tobramycin". Drug Information Portal. U.S. National Library of Medicine.
Blantyre Coma Scale
The Blantyre Coma Scale is a modification of the Pediatric Glasgow Coma Scale, designed to assess malarial coma in children. It was designed by doctors Terrie Taylor and Malcolm Molyneux in 1987, and named for the Malawian city of Blantyre, site of the Blantyre Malaria Project. Rancho Los Amigos Scale
The Rancho Los Amigos Scale is used to assess individuals after a closed head injury based on cognitive and behavioural presentations as they emerge from coma. It is named after the Rancho Los Amigos National Rehabilitation Center, located in Downey, California, United States. FOUR score
See also
Level of consciousness


== References ==