These include breathlessness, an increased rate of breathing, use of the chest and abdominal muscles to breathe, and lip pursing. : 642 Chronic hypoxemia may be compensated or uncompensated. The compensation may cause symptoms to be overlooked initially, however, further disease or a stress such as any increase in oxygen demand may finally unmask the existing hypoxemia. In a compensated state, blood vessels supplying less-ventilated areas of the lung may selectively contract, to redirect the blood to areas of the lungs which are better ventilated. However, in a chronic context, and if the lungs are not well ventilated generally, this mechanism can result in pulmonary hypertension, overloading the right ventricle of the heart and causing cor pulmonale and right sided heart failure. Polycythemia can also occur. In children, chronic hypoxemia may manifest as delayed growth, neurological development and motor development and decreased sleep quality with frequent sleep arousals.Other symptoms of hypoxemia may include cyanosis, digital clubbing, and symptoms that may relate to the cause of the hypoxemia, including cough and hemoptysis. : 642 Serious hypoxemia typically occurs when the partial pressure of oxygen in blood is less than 60 mmHg (8.0 kPa), the beginning of the steep portion of the oxygen–hemoglobin dissociation curve, where a small decrease in the partial pressure of oxygen results in a large decrease in the oxygen content of the blood. Severe hypoxia can lead to respiratory failure

Causes
Hypoxemia refers to insufficient oxygen in the blood.
As only a subset of patients with endothelial changes proceeded to epithelial involvement, Graves stated on 19 October 1925 to the New York Academy of Medicine that "Fuchs epithelial dystrophy may be a very late sequel to severer cases of the deeper affection". See also
Fuchs heterochromic iridocyclitis (a disease of the iris)
Ocular straylight

References
External links
Facts About the Cornea and Corneal Disease - The National Eye Institute (United States)
Fuchs dystrophy at Curlie