Welch then prepared stereoisomers of this compound, which were tested in vivo by animal behavioral scientist Albert Weissman. The most potent and selective (+)-isomer was taken into further development and eventually named sertraline. Weissman and Koe recalled that the group did not set up to produce an antidepressant of the SSRI type—in that sense their inquiry was not "very goal driven", and the discovery of the sertraline molecule was serendipitous. According to Welch, they worked outside the mainstream at Pfizer, and even "did not have a formal project team". The group had to overcome initial bureaucratic reluctance to pursue sertraline development, as Pfizer was considering licensing an antidepressant candidate from another company.Sertraline was approved by the US Food and Drug Administration (FDA) in 1991 based on the recommendation of the Psychopharmacological Drugs Advisory Committee; it had already become available in the United Kingdom the previous year. The FDA committee achieved a consensus that sertraline was safe and effective for the treatment of major depression. During the discussion, Paul Leber, the director of the FDA Division of Neuropharmacological Drug Products, noted that granting approval was a "tough decision", since the treatment effect on outpatients with depression had been "modest to minimal". Other experts emphasized that the drugs effect on inpatients had not differed from placebo and criticized poor design of the clinical trials by Pfizer.
Treatment
The most common treatment in animals is weekly use of some form of topical pesticide appropriate for the affected animal, often an antiflea product. Fipronil works well, especially in cats. Cats can also be treated with a lime sulfur insecticide dip or a shampoo with non-pyrethrin insecticide for two weeks beyond the conclusion of symptoms.In unresponsive cases, ivermectin is used. Selamectin is also recommended for treatment. None of these products are approved for treatment of cheyletiellosis. Other pets in the same household should also be treated, and the house or kennel must be treated with an environmental flea spray. Species
Cheyletiella blakei Smiley, 1970 — infests cats (Felis catus), USA (Washington DC)
Cheyletiella parasitivorax  — infests rabbits (Oryctolagus cuniculus), France
Cheyletiella romerolagi (Fain, 1972) — infests Romerolagus diazi, USA (New York)
Cheyletiella strandtmanni  Smiley, 1970 — infests hares (Lepus spp. ), Taiwan
Cheyletiella yasguri Smiley, 1965 — infests dogsC. yasguri and C. blakei can transiently affect humans. See also
List of mites associated with cutaneous reactions
Mange


== References ==