While the onset of action is slightly delayed in this method of administration, the ease of use and portability are what make naloxone nasal sprays useful.Narcan Nasal Spray was approved in 2015 and was the first FDA-approved nasal spray for emergency treatment or suspected overdose. Narcan Nasal Spray is prepackaged, requires no assembly, and delivers a consistent 4 mg dose of naloxone. It was developed in a partnership between LightLake Therapeutics and the National Institute on Drug Abuse. The approval process was fast-tracked. A generic version of the nasal spray was approved in the United States in 2019, though did not come to market until 2021.In 2021, the FDA approved Kloxxado, a 8 mg dose of intranasal naloxone developed by Hikma Pharmaceuticals. Citing the frequent need for multiple 4 mg doses of Narcan to successfully reverse overdose, packs of Kloxxado Nasal Spray contain two pre-packaged nasal spray devices, each containing 8 mg of naloxone. However, a wedge device (nasal atomizer) can also be attached to a syringe that may also be used to create a mist to deliver the drug to the nasal mucosa. This is useful near facilities where many overdoses occur that already stock injectors. Storage
Naloxone should be stored at room temperature and protected from light. For the auto-injector, naloxone should be stored in the outer case provided. If the product is cloudy, discolored, or contains particulate matter, use is not recommended.
Noting the high risk of overdose among people with HIV who inject drugs, international HIV donors including the Presidents Emergency Plan for AIDS Relief, the Global Fund to Fight AIDS, Tuberculosis and Malaria, and the Open Society Foundations, have supported the purchase and distribution of naloxone to those at risk in low- and middle income countries.In 2017, Next Harm Reduction in New York State began distributing naloxone and other harm reduction supplies by mail to those in the US unable to get them locally.In 2018, a maker of naloxone announced it would provide a free kit including two doses of the nasal spray, as well as educational materials, to each of the 16,568 public libraries and 2,700 YMCAs in the U.S.

Media
The 2013 documentary film Reach for Me: Fighting to End the American Drug Overdose Epidemic interviews people involved in naloxone programs aiming to make naloxone available to opioid users and people with chronic pain. Criticism
Some political commentators, law enforcement workers, and addiction specialists have argued naloxone enables opioid addiction and worsens the crisis. Some police officers report reviving the same addict multiple times and that the availability of naloxone have allowed some addicts to push their use over the edge. Conservative radio host Lars Larson noted that naloxone only works for an hour, and if a person does not receive stabilizing medical help in that time, the addict just overdoses again. Other critics have noted Narcan nasal sprays American manufacturer views colleges, schools, libraries, and community centers as "untapped markets" and a "growth opportunity."