Trigeminal trophic syndrome is a rare disease caused by the interruption of peripheral or central sensory pathways of the trigeminal nerve. A slowly enlarging, uninflammed ulcer can occur in the area that has had trigeminal nerve damage; including but not limited to the cheek beside the ala nasi. : 65  These sores affect the skin supplied by the sensory component of the trigeminal nerve. Similar lesions may also occur in the corners of the eyes, inside the ear canal, on the scalp or inside the mouth.It has been stated that the ulceration is due to the constant "picking" of the patient. While this does occur, the picking behavior is an incomplete explanation of the disease presentation: the lack of feeling or pain allows the patient to continue scratching or picking the area, and, although there is no feeling, there is constant neuropathic pain.Sixty cases were reported from 1982 to 2002. See also
Trigeminal neuralgia (Tic douloureux)
Skin lesion
List of cutaneous conditions
Somatosensory system


== References ==
Quartan fever is one of the four types of malaria which can be contracted by humans.It is specifically caused by the Plasmodium malariae species, one of the six species of the protozoan genus Plasmodium. Quartan fever is a form of malaria where an onset of fever occurs in an interval of three to four days, hence the name "quartan". It is transmitted by bites of infected female mosquitoes of the genus Anopheles. Symptoms include fevers which range from approximately 40–41 °C (104–106 °F) and occur periodically in 72 hour intervals. Although cases of malaria have occurred throughout the world, quartan fever typically occurs in the subtropics. Quartan fever is considered to be a less severe form of malaria fever that can be cured by anti-malarial medication, and prevention methods can be taken in order to avoid infection. Cause
The female Anopheles mosquito is a vector which transmits quartan fever to people. Mature mosquitoes carry uninucleate sporozoites in their salivary glands; these sporozoites enter a humans bloodstream when mosquitoes puncture human flesh during feeding. Sporozoites attack and inhabit liver parenchymal cells, called hepatocytes, in order to develop further. Once the uninucleate sporozoites have matured, the sporozoites then develop into uninucleate merozoites. Uninucleated merozoites mature into an erythrocytic stage called schizonts which contain merozoites. The schizonts, an infected erythrocyte, then rupture to release these merozoites; leading to more infections in the red blood cells.