The most common symptom that led to the incidental discovery of RIS is headache. Other common reasons are trauma, psychiatric disorders, and endocrinological disorders. Management
Currently, routine clinical follow-up and MRI neuroimaging surveillance is the standard by which patients are observed. While treatment of MS disease modifying therapies have been given to some individuals with RIS, the majority opt for active surveillance and the appearance of clinical symptoms before commencing treatment, as treatment is considered controversial. Prognosis
In a 5 year study, clinical events, which refers to the first symptoms of exacerbations, clinical attacks, flare ups, or severe symptoms, indicative of MS, appeared in 34% of individuals. Of those who developed symptoms, 9.6% fulfilled criteria for primary progressive multiple sclerosis (PPMS). Epidemiology
Due to the incidental nature of RIS, exact figures on prevalence is unknown, though it has been suggested that RIS is the most common type of asymptomatic MS. The prevalence may be higher in relatives of patients with MS. One study, at a university hospital that is located in a high region of MS disease incidence, put the disease prevalence at approximately 1 in 2000. An earlier study in 1961 of 15,644 autopsies found 12 cases (0.08%) of unexpected MS findings without a previous history of MS symptoms. The mean age of first indication of RIS from 451 patients is 37.2 years. RIS in children
Though rare, some children that have had MRI scans for reasons unrelated to MS have shown signs of RIS. The most common reason for an initial MRI in these children was a headache.
A stomach rumble, also known as a bowel sound, peristaltic sound, abdominal sound, bubble gut or borborygmus (pronounced ; plural borborygmi), is a rumbling, growling or gurgling noise produced by movement of the contents of the gastro-intestinal tract as they are propelled through the small intestine by a series of muscle contractions called peristalsis. A trained healthcare provider can listen to these intestinal noises with a stethoscope, but they may be audible enough to be heard with the naked ear as the fluid and gas move forward in the intestines (in the vicinity of, but not actually within the stomach). The lack of bowel sounds is indicative of ileus, intestinal obstruction, or some other serious pathology. Etymology
The scientific name borborygmus is related to the 16th-century French word borborygme, itself from Latin, ultimately from Ancient Greek βορβορυγμός (borborygmós). The Greeks probably onomatopoetically coined the word. Other causes
Other causes of stomach rumbles:

Incomplete digestion of food can lead to excess gas in the intestine. In humans, this can be due to incomplete digestion of carbohydrate-containing foods, including milk and other dairy products (lactose intolerance or the use of α-glucosidase inhibitors by diabetics), gluten (protein in wheat, barley, and rye) (coeliac disease), fruit, vegetables, beans, legumes, and high-fiber whole grains. In rare instances, excessive abdominal noise may be a sign of digestive disease, especially when accompanied by abdominal bloating, abdominal pain, diarrhea or constipation. Some examples of diseases that may be associated with this symptom include carcinoid neoplasm and coeliac sprue. Louder rumbles may occur when one is hungry.