An executioner might as well manicure his nails before chopping off a head".In 1844, Ignaz Semmelweis was appointed assistant lecturer in the First Obstetric Division of the Vienna General Hospital (Allgemeines Krankenhaus), where medical students received their training. Working without knowledge of Holmes essay, Semmelweis noticed his wards 16% mortality rate from fever was substantially higher than the 2% mortality rate in the Second Division, where midwifery students were trained. Semmelweis also noticed that puerperal fever was rare in women who gave birth before arriving at the hospital. Semmelweis noted that doctors in First Division performed autopsies each morning on women who had died the previous day, but the midwives were not required or allowed to perform such autopsies. He made the connection between autopsies and puerperal fever after a colleague, Jakob Kolletschka, died of sepsis after accidentally cutting his hand while performing an autopsy. Semmelweis began experimenting with various cleansing agents and, from May 1847, ordered all doctors and students working in the First Division wash their hands in chlorinated lime solution before starting ward work, and later before each vaginal examination. The mortality rate from puerperal fever in the division fell from 18% in May 1847 to less than 3% in June–November of the same year. While his results were extraordinary, he was treated with skepticism and ridicule (see Response to Semmelweis).
The exact etiology of Cuboid syndrome remains unclear but many ideas have been proposed. Such ideas include excessive pronation of the foot, overuse injury, and inversion ankle sprains. The favored idea is that the cuboid bone is forcefully everted while the calcaneus is inverted resulting in incongruity at the calcaneocuboid joint. The condition mainly affects athletes, especially those whose activities incur a significant amount of pressure on their feet from jumping or running (such as ballet dancers and runners) and those who place added strain on their feet during lateral maneuvering (such as tennis and basketball players). Cuboid syndrome may persist even if the patient is taking part in regular physical therapy. The patients foot type, such as the presence of overpronation or underpronation, may also play a factor in the condition. Risk factors
Suspected risk factors for Cuboid syndrome include obesity, midtarsal instability, poorly fitting footwear, physical exercise, inadequate recovery from physical activity, physical training on uneven surfaces, and ankle sprains. Diagnosis
Treatment
Once diagnosed, a medical professional may treat cuboid syndrome by realigning (also known as reducing) the subluxed cuboid unless contraindications to manipulation are present such as gout, inflammatory arthritis, bony disease, neurovascular compromise, or a bone fracture. This form of manual manipulation of the foot should be done by a trained specialist, such as an  orthopedic surgeon or podiatrist, or secondarily a chiropractor, osteopath, athletic trainer, osteopathic physician, or physical therapist. Further treatment may take into account other considerations, such as possible causes or aggravators (e.g.