In 2008 a serological point-of-care test for the early detection of RA  combined the detection of RF and anti-MCV with a sensitivity of 72% and specificity of 99.7%.To improve the diagnostic capture rate in the early detection of patients with RA and to risk stratify these individuals, the rheumatology field continues to seek complementary markers to both RF and anti-CCP. 14-3-3η (YWHAH) is one such marker that complements RF and anti-CCP, along with other serological measures like c-reactive protein. In a systematic review, 14-3-3η has been described as a welcome addition to the rheumatology field. The authors indicate that the serum based 14-3-η marker is additive to the armamentarium of existing tools available to clinicians, and that there is adequate clinical evidence to support its clinical benefits.Other blood tests are usually done to differentiate from other causes of arthritis, like the erythrocyte sedimentation rate (ESR), C-reactive protein, full blood count, kidney function, liver enzymes and other immunological tests (e.g., antinuclear antibody/ANA) are all performed at this stage. Elevated ferritin levels can reveal hemochromatosis, a mimic of RA, or be a sign of Stills disease, a seronegative, usually juvenile, variant of rheumatoid arthritis. Classification criteria
In 2010, the 2010 ACR / EULAR Rheumatoid Arthritis Classification Criteria were introduced.The new criteria are not diagnostic criteria, but are classification criteria to identify disease with a high likelihood of developing a chronic form.
Treatment
The most common treatment in animals is weekly use of some form of topical pesticide appropriate for the affected animal, often an antiflea product. Fipronil works well, especially in cats. Cats can also be treated with a lime sulfur insecticide dip or a shampoo with non-pyrethrin insecticide for two weeks beyond the conclusion of symptoms.In unresponsive cases, ivermectin is used. Selamectin is also recommended for treatment. None of these products are approved for treatment of cheyletiellosis. Other pets in the same household should also be treated, and the house or kennel must be treated with an environmental flea spray. Species
Cheyletiella blakei Smiley, 1970 — infests cats (Felis catus), USA (Washington DC)
Cheyletiella parasitivorax  — infests rabbits (Oryctolagus cuniculus), France
Cheyletiella romerolagi (Fain, 1972) — infests Romerolagus diazi, USA (New York)
Cheyletiella strandtmanni  Smiley, 1970 — infests hares (Lepus spp. ), Taiwan
Cheyletiella yasguri Smiley, 1965 — infests dogsC. yasguri and C. blakei can transiently affect humans. See also
List of mites associated with cutaneous reactions
Mange


== References ==