Edaravone, sold under the brand name Radicava among others, is a medication used to treat stroke and amyotrophic lateral sclerosis (ALS). It is given by intravenous infusion and by mouth.The most common side effects include bruising (contusions), problems walking (gait disturbances), and headaches.The mechanism by which edaravone might be effective is unknown. The medication is known to be an antioxidant, and oxidative stress has been hypothesized to be part of the process that kills neurons in people with ALS.The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. Medical uses
Edaravone is used to help people recover from stroke in Japan, and is used to treat ALS in the US and Japan. Adverse effects
The label carries a warning about the potential for hypersensitivity reactions to edaravone, and adverse effects include bruising, gait disturbances, headache, skin inflammation, eczema, problems breathing, excess sugar in urine, and fungal skin infections.The following adverse effects in at least 2% more people given the medication than were given placebo: bruising, gait disturbances, headache, skin inflammation, eczema, problems breathing, excess sugar in urine, and fungal skin infections.There is no data on whether it is safe for pregnant women to take, and it is unknown if edaravone is secreted in breast milk. Pharmacology
The mechanism by which edaravone might be effective in ALS is unknown.
Novolin is the brand name of three distinct insulin-containing products manufactured by Novo Nordisk:

Novolin 70/30, an insulin preparation containing mixed NPH and regular insulin, respectively
Novolin N, an insulin preparation containing NPH insulin
Novolin R, an insulin preparation containing regular insulin

See also
Insulin (medication)


== References ==