Indications for treatment include the presence of B symptoms, symptomatic organ involvement, increasing blood counts, hyperleukocytosis, leukostasis and/or worsening cytopenias.Blood transfusions and erythropoietin administration are used to raise haemoglobin levels in cases with anemia.Azacitidine is a drug approved by the U.S. Food and Drug Administration (FDA) for the treatment of CMML and by the European Medicines Agency (EMA) for high risk non-proliferative CMML with 10–19% marrow blasts. It is a cytidine analogue that causes hypomethylation of DNA by inhibition of DNA methyltransferase. Decitabine is a similar drug to azacitidine and is approved by the FDA for treatments of all subtypes of MDS, including CMML. Hydroxyurea is a chemotherapy that is used in the myeloproliferative form of CMML to reduce cell numbers. Decitabine/cedazuridine (Inqovi) is a fixed-dosed combination medication for the treatment of adults with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) that was approved for use in the United States in July 2020.Hematopoietic stem cell transplantation remains the only curative treatment for CMML. However, due to the late age of onset and presence of other illnesses, this form of treatment is often not possible. Epidemiology
There have been few individual epidemiological studies of CMML, due to the difficulty in the disease classification. CMML has an estimated incidence of less than 1 per 100,000 persons per year. The median age of diagnosis is 65–75. CMML has a propensity for males rather than females, at a ratio of 1.5–3:1. References


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A myoma is a type of tumor that involves muscle cells. There are two main types of myoma: 

Leiomyomas which occur in smooth muscle. They most commonly occur as uterine fibroids, but may also form in other locations. Rhabdomyomas which occur in striated muscle. They are rare tumors, occur in childhood and often become malignant.Whether or not angiomyomas are a type of leiomyoma or a separate entity is disputed as of 2014.Myomas are benign tumors of the uterus that can affect the fertility of a woman depending mainly on three factors:

Size (cut off value 4-5 cm)
Number
Location (they can be intramural, subserous or submucous). Submucous ones are worst from a fertility point of view, while subserous are less dangerous.Some of the most common symptoms are: abundant menstrual bleeding, longer menstrual periods, pelvic pressure, constipation, a need to urinate continuously. References


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