The diagnosis is established by sequencing the TYROBP and TREM2 genes. Differential diagnosis
Frontotemporal dementia

Investigations
X rays show the presence of bone cysts and osteoporosis. CT or MRI of the brain show loss of tissue in the frontotemporal lobes of the brain. Calcification of the basal ganglia is common. EEG is typically normal initially but diffuse slowing and irritative activity later. Treatment
There is no specific treatment for this condition. Management is supportive. Epidemiology
This condition is considered to be rare, with ~200 cases described in the literature. The estimated population prevalence is 2.0 x 10−6 in Finns. History
This condition was first described in 1973. == References ==
Alcaine is a municipality located in the province of Teruel, Aragon, Spain. According to the 2004 census (INE), the municipality had a population of 65 inhabitants. == References ==