Unfortunately, many surgical procedures have suboptimal outcomes, secondary to the myopathy of the syndrome.When operative measures are to be undertaken, they should be planned for as early in life as is feasible, in consideration of the tendency for fragile health. Early interventions hold the possibility to minimise developmental delays and negate the necessity of relearning basic functions.Due to the abnormal muscle physiology in Freeman–Sheldon syndrome, therapeutic measures may have unfavourable outcomes. Difficult endotracheal intubations and vein access complicate operative decisions in many DA2A patients, and malignant hyperthermia (MH) may affect individuals with FSS, as well. Cruickshanks et al. (1999) reports uneventful use of non-MH-triggering agents. Reports have been published about spina bifida occulta in anaesthesia management and cervical kyphoscoliosis in intubations. Medical emphasis
General health maintenance should be the therapeutic emphasis in Freeman–Sheldon syndrome. The focus is on limiting exposure to infectious diseases because the musculoskeletal abnormalities make recovery from routine infections much more difficult in FSS. Pneumonitis and bronchitis often follow seemingly mild upper respiratory tract infections. Though respiratory challenges and complications faced by a patient with FSS can be numerous, the syndromes primary involvement is limited to the musculoskeletal systems, and satisfactory quality and length of life can be expected with proper care. Prognosis
There are little data on prognosis. Rarely, some patients have died in infancy from respiratory failure; otherwise, life expectancy is considered to be normal. Epidemiology
By 1990, 65 patients had been reported in the literature, with no sex or ethnic preference notable.
Ismo may refer to:

-ism in Spanish, Portuguese, Esperanto and Italian
Ismo, a brand name for isosorbide mononitrate
Ismo Leikola, Finnish comedian