After healing, the lesions may leave pale marks before becoming dark scars.An unwell person may remain so for two to four weeks. Complications
Complications include secondary infections, pneumonia, sepsis, encephalitis, and loss of vision with severe eye infection. If infection occurs during pregnancy, still birth or birth defects may occur. The disease may be milder in people vaccinated against smallpox in childhood. Patel and colleagues, in the BMJ, demonstrate that this virus can produce severe symptoms, particularly in HIV-positive people. The  descriptive case series reveal that symptoms can be so severe that hospitalization is required in 10% of cases. The study also shows that 75% of patients (15 out of 20 participants) admitted to the hospital were HIV-positive individuals. Overall, the study depict a new variety of clinical manifestations including proctitis and rectal perforation. The pictures of genital lesions published in the BMJ show the severity of monkeypox, which is often described as causing moderate symptoms. In other animals
The disease has also been reported in dormice, tree squirrels, rope squirrels and non human primates. Rodents such as rats and mice are likely susceptible but not known. Signs and symptoms in animals vary among different species. Monkeypox infected Gambian pouched rats may have mild symptoms. During the 2003 US outbreak, affected prairie dogs presented with fever, cough, sore eyes, poor feeding and rash. Non-human primates present similarly. They may have breathing problems, facial swelling, mouth ulcers and swollen glands. In cynomolgus monkeys, the time from exposure to symptoms was noted to be around a week.
Villonodular synovitis is a type of synovial swelling. Types include:

Pigmented villonodular synovitis
Giant cell tumor of the tendon sheathThough they have very different names, they have the same histology, and stain positive for CD68, HAM56, and vimentin. They are sometimes discussed together. == References ==