Psychological
At normal therapeutic doses, the most common psychological side effects of amphetamine include increased alertness, apprehension, concentration, initiative, self-confidence and sociability, mood swings (elated mood followed by mildly depressed mood), insomnia or wakefulness, and decreased sense of fatigue. Less common side effects include anxiety, change in libido, grandiosity, irritability, repetitive or obsessive behaviors, and restlessness; these effects depend on the users personality and current mental state. Amphetamine psychosis (e.g., delusions and paranoia) can occur in heavy users. Although very rare, this psychosis can also occur at therapeutic doses during long-term therapy. According to the USFDA, "there is no systematic evidence" that stimulants produce aggressive behavior or hostility.Amphetamine has also been shown to produce a conditioned place preference in humans taking therapeutic doses, meaning that individuals acquire a preference for spending time in places where they have previously used amphetamine. Reinforcement disorders
Addiction
Addiction is a serious risk with heavy recreational amphetamine use, but is unlikely to occur from long-term medical use at therapeutic doses; in fact, lifetime stimulant therapy for ADHD that begins during childhood reduces the risk of developing substance use disorders as an adult. Pathological overactivation of the mesolimbic pathway, a dopamine pathway that connects the ventral tegmental area to the nucleus accumbens, plays a central role in amphetamine addiction. Individuals who frequently self-administer high doses of amphetamine have a high risk of developing an amphetamine addiction, since chronic use at high doses gradually increases the level of accumbal ΔFosB, a "molecular switch" and "master control protein" for addiction.
A valgus deformity is a condition in which the bone segment distal to a joint is angled outward, that is, angled laterally, away from the bodys midline. The opposite deformation, where the twist or angulation is directed medially, toward the center of the body, is called varus. Common causes of valgus knee (genu valgum or "knock-knee") in adults include arthritis of the knee and traumatic injuries. Knee arthritis with valgus knee
Rheumatoid knee commonly presents as valgus knee. Osteoarthritis knee may also sometimes present with valgus deformity though varus deformity is common. Total knee arthroplasty (TKA) to correct valgus deformity is surgically difficult and requires specialized implants called constrained condylar knees. Examples
Ankle: talipes valgus (from Latin talus = ankle and pes = foot) – outward turning of the heel, resulting in a flat foot presentation. Elbows: cubitus valgus (from Latin cubitus = elbow) – forearm is angled away from the body
Foot: pes valgus (from Latin pes = foot) – a medial deviation of the foot at subtalar joint. Hand: manus valgus (from Latin manus = hand)
Hip: coxa valga (from Latin coxa = hip) – the shaft of the femur is bent outward in respect to the neck of the femur. Coxa valga >125 degrees. Coxa vara <125 degrees. Knee: genu valgum (from Latin genu = knee) – the tibia is turned outward in relation to the femur, resulting in a knock-kneed appearance. Toe: hallux valgus (from Latin hallux = big toe) – outward deviation of the big toe toward the second toe, resulting in bunion.