There is also some activation of the HPA axis, producing glucocorticoids (cortisol, aka the S-hormone or stress-hormone). Stage 2
Resistance is the second stage. During this stage, increased secretion of glucocorticoids intensifies the bodys systemic response. Glucocorticoids can increase the concentration of glucose, fat, and amino acid in blood. In high doses, one glucocorticoid, cortisol, begins to act similarly to a mineralocorticoid (aldosterone) and brings the body to a state similar to hyperaldosteronism. If the stressor persists, it becomes necessary to attempt some means of coping with the stress. The body attempts to respond to stressful stimuli, but after prolonged activation, the bodys chemical resources will be gradually depleted, leading to the final stage. Stage 3
The third stage could be either exhaustion or recovery:

Recovery stage follows when the systems compensation mechanisms have successfully overcome the stressor effect (or have completely eliminated the factor which caused the stress). The high glucose, fat and amino acid levels in blood prove useful for anabolic reactions, restoration of homeostasis and regeneration of cells. Exhaustion is the alternative third stage in the GAS model. At this point, all of the bodys resources are eventually depleted and the body is unable to maintain normal function. The initial autonomic nervous system symptoms may reappear (sweating, raised heart rate, etc.).
Granuloma multiforme  is a cutaneous condition most commonly seen in central Africa, and rarely elsewhere, characterized by skin lesions that are on the upper trunk and arms in sun-exposed areas. : 707  It may be confused with tuberculoid leprosy, with which it has clinical similarities. The condition was first noted by Gosset in the 1940s, but it was not until 1964 that Leiker coined the term to describe "a disease resembling leprosy" in his study in Nigeria. See also
Skin lesion

References


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