Acute disseminated encephalomyelitis (ADEM), or acute demyelinating encephalomyelitis, is a rare autoimmune disease marked by a sudden, widespread attack of inflammation in the brain and spinal cord. As well as causing the brain and spinal cord to become inflamed, ADEM also attacks the nerves of the central nervous system and damages their myelin insulation, which, as a result, destroys the white matter. It is often triggered by a viral infection or (very rarely) vaccinations.ADEMs symptoms resemble the symptoms of multiple sclerosis (MS), so the disease itself is sorted into the classification of the multiple sclerosis borderline diseases. However, ADEM has several features that distinguish it from MS. Unlike MS, ADEM occurs usually in children and is marked with rapid fever, although adolescents and adults can get the disease too. ADEM consists of a single flare-up whereas MS is marked with several flare-ups (or relapses), over a long period of time. Relapses following ADEM are reported in up to a quarter of patients, but the majority of these multiphasic presentations following ADEM likely represent MS. ADEM is also distinguished by a loss of consciousness, coma and death, which is very rare in MS, except in severe cases. It affects about 8 per 1,000,000 people per year. Although it occurs in all ages, most reported cases are in children and adolescents, with the average age around 5 to 8 years old. The disease affects males and females almost equally.
Classified may refer to:

General
Classified information, material that a government body deems to be sensitive
Classified advertising or "classifieds"

Music
Classified (rapper) (born 1977), Canadian rapper
The Classified, a 1980s American rock band featuring Steve Vai
Classified Records, an American record label

Albums
Classified (Bond album), 2004
Classified (Classified album), 2013
Classified (Sweetbox album), 2001
Classified, by James Booker, 1982

Songs
"Classified", by C. W. McCall from Wolf Creek Pass, 1975
"Classified", by the Orb from Metallic Spheres, 2010
"Classified", by Pete Townshend from the compilation Glastonbury Fayre, 1972
"Classifieds", by the Academy Is... from Almost Here, 2005

Other media
Classified (1925 film), an American silent film
Classified: The Edward Snowden Story, a 2014 Canadian film
Classified: The Sentinel Crisis, a 2005 video game for the Xbox

See also
Classification (disambiguation)
Classifier (disambiguation)