Autoimmune diseases most commonly associated to Hashimotos thyroiditis include celiac disease, type 1 diabetes, vitiligo, and alopecia.The genes implicated vary in different ethnic groups and the incidence is increased in people with chromosomal disorders, including Turner, Down, and Klinefelter syndromes usually associated with autoantibodies against thyroglobulin and thyroperoxidase. Progressive depletion of these cells as the cytotoxic immune response leads to higher degrees of primary hypothyroidism, presenting with low T3/T4 levels, and compensatory elevations of TSH. Pathophysiology
Multiple  mechanisms by which the pathology of Hashimotos thyroiditis develops have been suggested. Various autoantibodies may be present against thyroid peroxidase, thyroglobulin and TSH receptors, although a small percentage of people may have none of these antibodies present. As indicated in various twin studies, a percentage of the population may also have these antibodies without developing Hashimotos thyroiditis. Nevertheless, antibody-dependent, cell-mediated cytotoxicity is a substantial factor behind the apoptotic fall-out of Hashimotos thyroiditis. Activation of cytotoxic T-lymphocytes (CD8+ T-cells) in response to cell-mediated immune response affected by helper T-lymphocytes (CD4+ T-cells) is central to thyrocyte destruction. As is characteristic of type IV hypersensitivities, recruitment of macrophages is another effect of the helper T-lymphocyte activation, with Th1 axis lymphocytes producing inflammatory cytokines within thyroid tissue to further macrophage activation and migration into the thyroid gland for direct effect.Gross morphological changes within the thyroid are seen in the general enlargement, which is far more locally nodular and irregular than more diffuse patterns (such as that of hyperthyroidism).
The Tatars of the Altai had a similar myth, thought to be of Native North American origin, involving the fragments of the dead giant, Andalma-Muus, becoming mosquitoes and other insects. Modern era
Winsor McCays 1912 film How a Mosquito Operates was one of the earliest works of animation, which has been described as far ahead of its time in technical quality. It depicts a giant mosquito tormenting a sleeping man.The de Havilland Mosquito was a high-speed aircraft manufactured between 1940 and 1950, and used in many roles. References
Further reading
External links

Mosquito at Curlie
Mosquito Information Website
Mosquitoes chapter in United States Environmental Protection Agency National Public Health Pesticide Applicator Training Manual
A film clip describing The Life Cycle of the Mosquito is available at the Internet Archive
"Mosquitoes: The Worst". Stuff You Should Know (Podcast). Retrieved 2015-06-30. Parasitic Insects, Mites and Ticks: Genera of Medical and Veterinary Importance Wikibooks