Saquinavir (SQV), sold under the brand names Invirase and Fortovase, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS. Typically it is used with ritonavir or lopinavir/ritonavir to increase its effect. It is taken by mouth.Common side effects include nausea, vomiting, diarrhea, and feeling tired. More serious side effects include problems with QT prolongation, heart block, high blood lipids, and liver problems. It appears to be safe in pregnancy. It is in the protease inhibitor class and works by blocking the HIV protease.Saquinavir was patented in 1988 and first sold in 1995. Medical uses
Saquinavir is used together with other medications to treat or prevent HIV/AIDS. Typically it is used with ritonavir or lopinavir/ritonavir to increase its effect. Side effects
The most frequent adverse events with saquinavir in either formulation are mild  gastrointestinal symptoms, including diarrhoea, nausea, loose stools and abdominal discomfort. Invirase is better tolerated than Fortovase. Bioavailability and drug interactions
Saquinavir, in the Invirase formulation, has a low and variable oral bioavailability, when given alone. The Fortovase formulation at the standard dosage delivers approximately eightfold more active drug than Invirase, also at the standard dosage.In the clinic, it was found that the oral bioavailability of saquinavir in both formulations significantly increases when patients also receive the PI ritonavir.
The first symptom that shows signs of Hashimotos thyroiditis is a goiter on the front of the neck. Depending on the severity of the disease and how much it has progressed, doctors then decide what steps are taken for treatment. See also
Hypothyroidism
Hashitoxicosis
Hyperthyroidism
Hashimotos disease
Thyroid cancer

References
External links
American Thyroid Association, "What is Thyroiditis"