Anemia caused by kidney disease
For people who require dialysis or have chronic kidney disease, iron should be given with erythropoietin, depending on some laboratory parameters such as ferritin and transferrin saturation. Dialysis patients in the U.S. are most often given Epogen; other brands of epoetin may be used in other countries.Erythropoietin is also used to treat anemia in people with chronic kidney disease who are not on dialysis (those in Stage 3 or 4 disease and those living with a kidney transplant). There are two types of erythropoietin for people with anemia due to chronic kidney disease (not on dialysis). Anemia caused by cancer
In March 2008, a panel of advisers for the U.S. Food and Drug Administration (FDA) supported keeping erythropoiesis-stimulating agents (ESAs) produced by Amgen and Johnson & Johnson on the market for use in cancer patients. The FDA has focused its concern on study results from some clinical trials showing an increased risk of death and tumor growth in chemotherapy patients taking the anti-anemia drugs. Anemia in critically ill people
Erythropoietin is used to treat people with anemia resulting from critical illness. In a randomized controlled trial, erythropoietin was shown to not change the number of blood transfusions required by critically ill patients. A surprising finding in this study was a small mortality reduction in patients receiving erythropoietin. This result was statistically significant after 29 days but not at 140 days. The mortality difference was most marked in patients admitted to the ICU for trauma.
Knuckle pads (also known as "Heloderma", meaning similar to the skin of the Gila monster lizard for which it is named) are circumscribed, keratotic, fibrous growths over the dorsa of the interphalangeal joints. They are described as well-defined, round, plaque-like, fibrous thickening that may develop at any age, and grow to be 10 to 15mm in diameter in the course of a few weeks or months, then go away over time.Knuckle pads are sometimes associated with Dupuytrens contracture and camptodactyly,: 595  and histologically, the lesions are fibromas. : 595  Knuckle pads are generally non-responsive to treatment, including corticosteroids, and tend to recur after surgery; however, there has been some effectiveness with intralesional fluorouracil. See also
Skin lesion
List of cutaneous conditions
Garrods pad

References
Further reading
Guberman D;  et al. (1996). ""Knuckle pads-a forgotten skin condition " report of a case and review of the literature". Cutis. 57 (4): 241–242. PMID 8727774. Ly Y;  et al. (2003). "A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads". Am J Med Genet. 120A (3): 345–9. doi:10.1002/ajmg.a.20090. PMID 12838553. Peterson CM;  et al. (2000). "Knuckle pads: does knuckle cracking play an etiologic role?". Pediatr Dermatol. 17 (6): 450–2. doi:10.1046/j.1525-1470.2000.01819.x. PMID 11123776. == External links ==