It rapidly binds to the GnRH receptor cells in the pituitary gland thus leading to an initial increase in production of luteinizing hormone and thus leading to an initial increase in the production of corresponding sex hormones. This initial flare may be treated by co-prescribing/co-administering an androgen receptor antagonist such as bicalutamide (Casodex). Eventually, after a period of about 14–21 days, production of LH is greatly reduced due to receptor downregulation, and sex hormones are generally reduced to castrate levels. Chemistry
Goserelin is a GnRH analogue and decapeptide. It is provided as the acetate salt. Society and culture
Generic names
Goserelin is the generic name of the drug and its INN, USAN, and BAN. References
External links
"Goserelin acetate". Drug Information Portal. U.S. National Library of Medicine.
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