These recommendations take into account considerations for the efficacy and longevity of each specific vaccine; the exposure, risk, and need of different cat populations; and socioeconomic limitations.Recommendations vary for:

animal shelters
boarding facilities (or animals going into them)
breeders
community cats (free-roaming and/or feral) or TNR (Trap Neuter Return) programs
owned pets (and based on "inside only" or "in and out")The FPLV vaccination is considered a "core" (essential for health) vaccine and is recommended for all domestic cats. Even cats kept indoors can be infected from fomite transmission.Several types and brands of commercial FPLV vaccines are available to induce acquired immunity. These include: 

killed virus ("non-infectious") adjuvanted
killed virus non adjuvanted
modified-live virus (MLV or "infectious") adjuvanted
modified-live virus non adjuvantedCombination vaccines that protect against several common viruses, including FPLV, are also available. Selection or use of a specific type/brand of a vaccine may vary depending on the overall risk of viral infection to the specific animal in its environment, along with considerations for the time it takes to confer protection, its overall efficacy, the animals health, and the potential risks associated with MLV vs killed, adjuvanted vs nonadjuvanted, intranasal/ocular vs injection. Modified-live FPLV vaccines are not recommended in pregnant queens, very young kittens, or cats with FIV or FeLV.Kittens without maternally derived antibodies are especially vulnerable. FPLV vaccination can start as early as 4 weeks of age for kittens at high risk but are usually started at 6 weeks, then given every 3 – 4 weeks until 16 weeks of age.
These tests are used extra-label because they allow rapid, inexpensive, in-house detection of the virus.) Some cats will have completed the shedding period by the time the test is run, leading to false-negative results. Electron microscopy, virus isolation and seroconversion can also be used to document active or recent infection. Leukopenia on a complete blood count (nadir 50–3,000 WBC/μL) supports a diagnosis of FPLV. In an unvaccinated cat, the presence of antibodies against FPV indicates that the cat either has the disease or has had the disease in the past. Elevated IgM titers (1:10 or greater) indicate active infection and if clinical signs are obvious (diarrhea, panleukopenia) the prognosis is poor. Elevated IgG titers (1:100 or greater) in a cat with clinical signs indicates a better prognosis.Differential diagnoses include salmonellosis, enteric toxins, feline immunodeficiency virus (FIV), feline leukemia virus (FeLV), cryptosporidiosis, pancreatitis, septicaemia with acute endotoxemia, toxoplasmosis, peritonitis, and lymphoma. Treatment
To contain the virus, cats with suspected or diagnosed FPLV should be kept in isolation.It requires immediate, aggressive treatment if the cat is to survive, as it can be fatal in less than 24 hours. Several articles and publications provide guidance for rescuers and veterinarians for optimizing outcomes.Treatment involves:
anti-emetics
IV antibiotics
intravenous fluids with electrolytes
injections of vitamin B
plasma or whole blood transfusionFeeding should be continued as long as possible. A highly digestible diet is preferred, but the individual animals preferences may dictate giving whatever it will eat.