However, the pathophysiology of depression and mental stress during PCOS is linked to various changes including psychological changes such as high activity of pro-inflammatory markers and immune system during stress.PCOS is associated with other mental health related conditions besides depression such as Anxiety, Bipolar disorder, and Obsessive–compulsive disorder. Hirsutism and acne
When appropriate (e.g., in women of child-bearing age who require contraception), a standard contraceptive pill is frequently effective in reducing hirsutism. Progestogens such as norgestrel and levonorgestrel should be avoided due to their androgenic effects. Metformin combined with an oral contraceptive may be more effective than either metformin or the oral contraceptive on its own.Other medications with anti-androgen effects include flutamide, and spironolactone, which can give some improvement in hirsutism. Metformin can reduce hirsutism, perhaps by reducing insulin resistance, and is often used if there are other features such as insulin resistance, diabetes, or obesity that should also benefit from metformin. Eflornithine (Vaniqa) is a medication that is applied to the skin in cream form, and acts directly on the hair follicles to inhibit hair growth. It is usually applied to the face. 5-alpha reductase inhibitors (such as finasteride and dutasteride) may also be used; they work by blocking the conversion of testosterone to dihydrotestosterone (the latter of which responsible for most hair growth alterations and androgenic acne).
Wera may refer to:

PeopleJulian Wera (1902–1975), Major League Baseball third baseman
Wera Engels, German actress
Wera Hobhouse, British politician
Wera Sæther (born 1945), Norwegian psychologist, poet, novelist, essayist, writer of books for youth and of documentary booksOtherWERA (Western Eastern Roadracing Association), motorcycle racing sanctioning body
WERA-LP, a low-power radio station (96.7 FM) licensed to serve Arlington, Virginia, United States
Wera River, river of Flores, Indonesia
Wera Tools, the popular name for German tool manufacturer, Wera Werk Hermann Werner GmbH & Co. KG, of Wuppertal, Germany
A defunct radio station in Plainfield, New Jersey on 1590 kilocycles per second