Absorption/distribution: The half-life of oral paracetamol is 1.25 to 3 hours and peak level is reached by 10–60 minutes after ingestion. Metabolism/excretion: Paracetamol is metabolized primarily in the liver via glucuronidation and sulfation to mostly non-toxic metabolites and some highly reactive metabolites, which is inactivated by glutathione. 85% of the oral dose is excreted renally. At high doses, the supply of glutathione cannot meet its demand, thus results in the accumulation of highly reactive compounds leading to liver damage. Society and culture
In May 2017, professional golfer Tiger Woods was arrested by the police for driving under the influence. Woods said that this was due to four prescription drugs that he was taking for a back operation, one of which was Vicodin. Legal status
On 30 June 2009, a U.S. Food and Drug Administration (FDA) advisory panel voted by a narrow margin to advise the FDA to remove Vicodin and another opioid, Percocet, from the market because of "a high likelihood of overdose from prescription narcotics and acetaminophen products". The panel also cited concerns of liver damage from their paracetamol component, which is also the main ingredient in commonly used nonprescription drugs such as Tylenol. Each year, paracetamol overdose is linked to about 400 deaths and 42,000 hospitalizations.In January 2011, the FDA asked manufacturers of prescription combination products that contain paracetamol to limit the amount of paracetamol to no more than 325 mg in each tablet or capsule within three years.
The FDA also required manufacturers on all paracetamol containing products to issue a black box warning indicating the potential risk for severe liver injury and a warning highlighting potential for allergic reactions.On 22 August 2014, the Drug Enforcement Administration (DEA) announced that all hydrocodone combination products (HCPs) will be rescheduled from Schedule III to Schedule II of the Controlled Substances Act (CSA), effective on 6 October 2014. In 2010, more than 16,000 deaths were attributed to abuse of opioid drugs. Even though there are legitimate medical uses for HCPs, data suggest that a significant number of individuals misuse them. Popular culture
Vicodin is mentioned in songs such as Juice Wrlds "Already Dead" Eminems "Kill You", Blackbears "Sniffing Vicodin in Paris", Kendrick Lamars "A.D.H.D", Futures "Lay Up", Lupe Fiascos "Mural", Queens of the Stone Ages "Feel Good Hit of the Summer", A Winged Victory for the Sullens "Steep Hills of Vicodin Tears", Death Gripss "Anne Bonny" and The Wombats "Give Me a Try". Vicodin use is a central theme in the 2004–2012 medical TV drama House, in which the lead character Dr. Gregory House is addicted to the drug combination. Brand names
Brand names include Adol, Hycet, Lortab, Lorcet, Norco, and Vicodin among others. See also
Hydrocodone/aspirin
Hydrocodone/ibuprofen
Oxycodone/paracetamol

References
External links
"Acetaminophen mixture with Hydrocodone bitartrate". Drug Information Portal. U.S. National Library of Medicine. Vicodin U.S. Federal Regulations Archived 18 January 2017 at the Wayback Machine