Hypophosphatemic rickets are associated with at least nine other genetic mutations. Clinical management of hypophosphatemic rickets may differ depending on the specific mutations associated with an individual case, but treatments are aimed at raising phosphate levels to promote normal bone formation. Symptoms and signs
The most common symptoms of XLH affect the bones and teeth, causing pain, abnormalities, and osteoarthritis. Symptoms and signs can vary between children and adults and can include:
Children

Adults

Osteomalacia
Dental abscesses
Limited range of movement (enthesopathy)
Short stature
Fatigue
Fractures / pseudofracture
Bone pain
Craniostenosis
Osteoarthritis
Spinal stenosis
Hearing loss
Depression

Genetics
XLH is associated with a mutation in the PHEX gene sequence, located on the human X chromosome at location Xp22.2-p22.1. The PHEX protein regulates another protein called fibroblast growth factor 23 (produced from the FGF23 gene). Fibroblast growth factor 23 normally inhibits the kidneys ability to reabsorb phosphate into the bloodstream. Gene mutations in PHEX prevent it from correctly regulating fibroblast growth factor 23. The resulting overactivity of FGF-23 reduces vitamin D 1α-hydroxylation and phosphate reabsorption by the kidneys, leading to hypophosphatemia and the related features of hereditary hypophosphatemic rickets. Also in XLH, where PHEX enzymatic activity is absent or reduced, osteopontin—a mineralization-inhibiting secreted substrate protein found in the extracellular matrix of bone—accumulates in bone (and teeth) to contribute to the osteomalacia (and odontomalacia) as shown in the mouse homolog (Hyp) of XLH and in XLH patients. Biochemically in blood, XLH is recognized by hypophosphatemia and an inappropriately low level of calcitriol (1,25-(OH)2 vitamin D3).
In general, these trucks are composed of a chassis, a motor, a transmission, a cabin, an area for the placement of the load and the equipment, axles of transmission, suspensions, direction, tires, electrical, pneumatic, hydraulic, engine cooling systems, and brakes. They can be operated with a gasoline engine or with a diesel engine, there are four-wheel drive (4x4) vehicles, six wheeled (6x6), eight wheeled (8x8), ten wheeled (10x10) and even twelve wheeled vehicles (12x12). Types of military vehicles
Land combat and military transport vehicles include:

See also
Military transport (equipment) not primarily used on land:
Military aircraft
Military spacecraft
Naval ships
Warships
Camouflage
List of military vehicles


== References ==