He studied medicine at the University of Kiel, qualifying in 1899. He later became head of the Bonn University’s ophthalmology clinic, followed by a post as chair of ophthalmology at the University of Marburg. In 1909 he described 7 patients with a recessively inherited macular dystrophy, now known as Stargardt’s disease. Research
There are several clinical trials in various stages involving several potential therapeutic areas, gene therapy, stem cell therapy, drug therapy and artificial retinas. In general all are testing the safety and benefits of their respective therapies in phase I or II trials. These studies are designed to evaluate the safety, dose and effectiveness in small number of people in Phase I with Phase II evaluating similar criteria in a larger population but including a greater insight into potential side effects.Gene therapy is designed to insert a copy of a corrected gene into retinal cells. The hope is to return cell function back to normal and the treatment has the potential to stop disease progression. This therapy will not restore impaired vision back to normal. The research is being undertaken by a partnership between Sanofi and Oxford BioMedica. A Lentiviral vector is used to deliver a normal gene to the target tissue via a subretinal injection. The therapy is known as SAR422459 and it has been terminated prematurely due to halt in developing the drug product.Kubota Vision is in Phase III clinical trials of a visual cycle modulator that modulates RPE65 activity to treat Stargardts.
Capillariasis is a disease in the group of helminthiasis diseases caused by the nematode Capillaria philippinensis. Symptoms and signs
Symptoms in infested humans include watery diarrhea, abdominal pain, edema, weight loss, borborygmus (stomach growling), and depressed levels of potassium and albumin in the blood. In humans, the parasites damage the cells of the intestinal wall. This damage interferes with the absorption of nutrients and the maintenance of a proper electrolyte balance. Untreated C. philippinensis infestations are often fatal. Diagnosis
Diagnosis usually involves finding the eggs and/or adults of C. philippinensis in stool samples. Prevention
Prevention is as simple as avoiding eating small, whole, uncooked fish. However, in C. philippinensis endemic areas, such dietary habits are common and have been practiced for many generations. Treatment
Anthelmintics such as mebendazole and albendazole have been reported to eliminate infestation of humans more effectively than thiabendazole. References


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