Symptoms of these diseases include an unusually high rate of breathing (tachypnea), a blue hue to the skin (cyanosis), wheezing, a rapid heartbeat (tachycardia), and/or an abnormally enlarged liver, which are similar to those of other congenital heart problems (hepatomegaly). VSDs can also lead to a build-up of fluid around the heart, which can lead to congestive heart failure. Atrioventricular septal defect
Atrioventricular septal defect (AVSD) is an uncommon congenital heart condition characterized by faulty development of the hearts septa and valves. Congestive heart failure is common in infants with the entire version of the condition. Fluid builds up in other parts of the body, particularly the lungs. Breathing difficulties may result from pulmonary congestion (dyspnea). Mitral valve stenosis
Mitral valve stenosis is an uncommon cardiac abnormality that can occur at birth (congenital) or develop later in life (acquired). The aberrant narrowing of the mitral valves opening characterizes this condition. There are two versions of this condition known as congenital and acquired characterized by different symptoms. Congenital Mitral valve stenosis symptoms include a wide array such as respiratory infections, breathing difficulties, heart palpitations and coughing. Acquired mitral valve stenosis symptoms also include a wide array such as consciousness losses, angina, general weakness and abdominal discomfort. Notable cases
Shaun White, American professional snowboarder and skateboarder
Beau Casson, Australian cricketer
Dennis McEldowney, New Zealand author and publisher
Max Page, Volkswagens "Little Darth Vader" from the 2011 Super Bowl commercial
Billy Kimmel, the son of talk show host Jimmy Kimmel; Billys diagnosis led Kimmel to discuss access to health care on his show Jimmy Kimmel Live!
Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.The prodrug alclometasone dipropionate was originally marketed under the brand name Aclovate by GlaxoSmithKline as a topical cream and ointment. However, generic versions of the drug are available. Medical uses
Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:

atopic dermatitis
eczema
psoriasis
allergic dermatitis
contact dermatitis
actinic dermatitis
kiss-type allergy
skin itchAlclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients. Contraindications
hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
cutaneous tuberculosis
chicken pox
perioral dermatitis
acne
rosacea
open wounds
trophic ulcers
viral infection of skin
skin manifestations of syphilis

Side effects
Adverse reactions (sometimes, less than 1-2% cases) include:

burning
itching
erythema
skin reddening
xerodermia
skin irritation
acne
hypopigmentation
prickly heat
folliculitis
white atrophy
hypertrichosis
reinfection of skin

Pharmacology
Alclometasone induces the production of lipocortins, formally known as annexins, which inhibit phospholipase A2 – the enzyme responsible for the synthesis of arachidonic acid. Without the oxidation of arachidonic acid, eicosanoids, such as prostaglandins, thromboxanes, and leukotrienes, cant be produced. Alclometasone also inhibits the release of pro-inflammatory mediators from leukocytes (e.g., cytokines, histamine, leukotrienes, serotonin). Formulations
Alclometasone as Aclovate is supplied in:

Cream; Topical; 0.05%
Ointment; Topical; 0.05%


== References ==