In the 1970s it was recognised that combining isoniazid and rifampin could reduce the duration of treatment from 18 to nine months, and in the 1980s the duration of treatment was further shortened by adding pyrazinamide. National and international guidelines
See also
Modern era
ATC code J04 Drugs for treatment of TB
Mantoux test
Heaf test
TB Alliance
Tuberculosis management in the era before antituberculosis drugs
History of tuberculosis
Tuberculosis treatment in Colorado Springs (historical)

References
 This article incorporates public domain material from websites or documents of the Centers for Disease Control and Prevention. == Further reading ==
When this section is removed, the bile acids pass into the large bowel and cause diarrhea due to stimulation of chloride/fluid secretion by the colonocytes resulting in a secretory diarrhea. Colestyramine prevents this increase in water by making the bile acids insoluble and osmotically inactive. Colestyramine is also used in the control of other types of bile acid diarrhea. The primary, idiopathic form of bile acid diarrhea is a common cause of chronic functional diarrhea, often misdiagnosed as diarrhea-predominant irritable bowel syndrome (IBS-D), and most of these patients respond to colestyramine. It is beneficial in the treatment of postcholecystectomy syndrome chronic diarrhea. Colestyramine is also useful in treating post-vagotomy diarrhea.Colestyramine can be helpful in the treatment of Clostridium difficile infections, to absorb toxins A and B, and reduce the diarrhea and the other symptoms these toxins cause. However, because it is not an anti-infective, it is used in concert with vancomycin.It is also used in the "wash out" procedure in patients taking leflunomide or teriflunomide to aid drug elimination in the case of drug discontinuation due to severe side effects caused by leflunomide or teriflunomide.A case report suggests that colestyramine may be useful for cyanobacterial (microcystin) poisoning in dogs.Ointments containing colestyramine compounded with aquaphor have been used in topical treatment of diaper rash in infants and toddlers.Cholestyramine also binds with oxalate in the GI tract, ultimately reducing urine oxalate and calcium oxalate stone formation. Available forms
Colestyramine is available as powder form, in 4-g packets, or in larger canisters.