Lomustine (INN); abbreviated as CCNU; original brand name CeeNU, now marketed as Gleostine) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug, thus it crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, which is its primary use, although it is also used to treat Hodgkin lymphoma as a second-line option. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number). Unlike carmustine, lomustine is administered orally. It is a bifunctional alkylating agent, alkylates both DNA and RNA, has the ability to created interstrand cross-links (ICLs) in DNA. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins. Lomustine is cell-cycle nonspecific. It has also been used in veterinary practice as a treatment for mast cell tumors in dogs. Price increase
In the U.S., the patent for lomustine has expired, but only one company manufactures it. In 2013, Bristol-Myers Squibb Co. sold its CeeNU brand of lomustine to CordenPharma, a subsidiary of International Chemical Investors S.E., which markets it as Gleostine through NextSource Biotechnology. In 2013, BMS charged $50 a capsule. In 2018, NextSource charged $768 a capsule. Some doctors said the price increase made it unaffordable, and one doctor called it "price gouging."
The rank of "Protopresbyter" as a distinction higher than "Archpriest" is a later addition. The same Order, naturally, is used for what is now called "Protopresbyter". Other uses
The Unitarian Church of Transylvania is divided into five Archpriestships as a form of territorial governance, virtual dioceses. See also
Archimandrite
Archpriest Controversy
Arnaud de Cervole, also known as "the Archpriest"
Archpriest of Hita
Protopope

Notes
References and sources
References

Sources

Cross, F. L., ed. (1957). Oxford Dictionary of the Christian Church. London: Oxford University Press; pp. 79–80

Further reading
Amanieu, A. (1935). "Archiprêtre", in: Dictionnaire de Droit Canonique. Coll. 1004–26. Includes good bibliography. External links
"Archpriest in Catholic Encyclopedia". NewAdvent (organization).