It is unclear how a reduced amount of this protein during development leads to learning disabilities, overgrowth, and the other features of Sotos syndrome.About 95 percent of Sotos syndrome cases occur by spontaneous mutation. Most of these cases result from new mutations involving the NSD1 gene. A few families have been described with more than one affected family member. These inherited cases enabled researchers to determine that Sotos syndrome has an autosomal dominant pattern of inheritance. Diagnosis
Diagnosis is based on physical examination, looking for excessive growth among other symptoms. There are no biochemical markers for the disease. Treatment
Treatment is symptomatic. There is no standard course of treatment for Sotos syndrome. Prognosis
Sotos syndrome is not a life-threatening disorder and patients may have a normal life expectancy. Developmental delays may improve in the school-age years; however, coordination problems may persist into adulthood, along with any learning disabilities and/or other physical or mental issues. Epidemiology
Incidence is approximately 1 in 14,000 births. See also
Beckwith-Wiedemann syndrome
Perlman syndrome
Proteus syndrome

References
External links
 Media related to Sotos syndrome at Wikimedia Commons
sotos at NIH/UW GeneTests
Diagnosis
Classification
Sinusitis (or rhinosinusitis) is defined as an inflammation of the mucous membrane that lines the paranasal sinuses and is classified chronologically into several categories:
Acute sinusitis – A new infection that may last up to four weeks and can be subdivided symptomatically into severe and nonsevere. Some use definitions up to 12 weeks. Recurrent acute sinusitis – Four or more full episodes of acute sinusitis that occur within one year
Subacute sinusitis – An infection that lasts between four and 12 weeks, and represents a transition between acute and chronic infection. Chronic sinusitis – When the signs and symptoms last for more than 12 weeks. Acute exacerbation of chronic sinusitis – When the signs and symptoms of chronic sinusitis exacerbate, but return to baseline after treatment.Roughly 90% of adults have had sinusitis at some point in their lives. Acute
Health care providers distinguish bacterial and viral sinusitis by watchful waiting. If a person has had sinusitis for fewer than 10 days without the symptoms becoming worse, then the infection is presumed to be viral. When symptoms last more than 10 days or get worse in that time, then the infection is considered bacterial sinusitis. Pain in the teeth and bad breath are also more indicative of bacterial disease.Imaging by either X-ray, CT or MRI is generally not recommended unless complications develop. Pain caused by sinusitis is sometimes confused for pain caused by pulpitis (toothache) of the maxillary teeth, and vice versa.