Certain methylations are believed to secure DNA in a silenced state, and therefore demethylation may reduce the stability of silencing signals and confer relative gene activation.Azacitidine induces tumor regression on isocitrate dehydrogenase-1 mutant glioma xenografts in mice.In research, 5-azacitidine is commonly used for promoting cardiomyocyte differentiation of adult stem cells. However, it has been suggested that this drug has a compromised efficacy as a cardiac differentiation factor because it promotes the transdifferentiation of cardiac cells to skeletal myocytes.Azacitidine also has antiviral effects in animal studies as well as its anti-cancer actions, but has not been tested for clinical use. References
External links
"Azacitidine". Drug Information Portal. U.S. National Library of Medicine. Clinical trial number NCT02447666 for "Study With Azacitidine in Pediatric Subjects With Newly Diagnosed Advanced Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML)" at ClinicalTrials.gov
Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. As with many antihistamines, the most common side effect is drowsiness.It was patented in 1948 and came into medical use in 1953. See also
Benztropine
Pseudoephedrine
UK-9040


== References ==