Influential members of the administration became less enthusiastic about methods they saw as promoting an over reliance on the state, as they feared that might assist the spread of communism. By the 1980s, the previous consensus in favour of moderate government intervention had been displaced across the western world. The IMF and World Bank in particular began to promote market-based solutions. In cases where countries became dependent on the IMF, they sometimes forced national governments to prioritize debt repayments and sharply cut public services. This sometimes had a negative effect on efforts to combat hunger. Organizations such as Food First raised the issue of food sovereignty and claimed that every country on earth (with the possible minor exceptions of some city-states) has sufficient agricultural capacity to feed its own people, but that the "free trade" economic order, which from the late 1970s to about 2008 had been associated with such institutions as the IMF and World Bank, had prevented this from happening. The World Bank itself claimed it was part of the solution to hunger, asserting that the best way for countries to break the cycle of poverty and hunger was to build export-led economies that provide the financial means to buy foodstuffs on the world market. However, in the early 21st century the World Bank and IMF became less dogmatic about promoting free market reforms.
Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia in which plasma cells or other types of antibody-producing cells secrete a myeloma protein, i.e. an abnormal antibody, into the blood; this abnormal protein is usually found during standard laboratory blood or urine tests. MGUS resembles multiple myeloma and similar diseases, but the levels of antibodies are lower, the number of plasma cells (white blood cells that secrete antibodies) in the bone marrow is lower, and it rarely has symptoms or major problems. However, since MGUS can lead to multiple myeloma, which develops at the rate of about 1.5% a year, or other symptomatic conditions, yearly monitoring is recommended. The progression from MGUS to multiple myeloma usually involves several steps. In rare cases, it may also be related with a slowly progressive symmetric distal sensorimotor neuropathy. Signs and symptoms
People with monoclonal gammopathy generally do not experience signs or symptoms. Some people may experience a rash or nerve problems, such as numbness or tingling. MGUS is usually detected by chance when the patient has a blood test for another condition or as part of standard screening. Pathophysiology
Pathologically, the lesion in MGUS is in fact very similar to that in multiple myeloma.