Pachygyria (from the Greek "pachy" meaning "thick" or "fat" gyri) is a congenital malformation of the cerebral hemisphere. It results in unusually thick convolutions of the cerebral cortex. Typically, children have developmental delay and seizures, the onset and severity depending on the severity of the cortical malformation. Infantile spasms are common in affected children, as is intractable epilepsy. Presentation
The term pachygyria does not directly relate to a specific malformation but rather is used to generally describe physical characteristics of the brain in association with several neuronal migration disorders; most commonly disorders relating to varied degrees of lissencephaly. Lissencephaly is present in 1 of 85,470 births and the life span of those affected is short as only a few survive past the age of 20. Pachygyria is a condition identified by a type of cortical genetic malformation. Clinicians will subjectively determine the malformation based on the degree of malposition and the extent of thickened abnormal grey differentiation present. Connections to epilepsy, lissencephaly, and subcortical band heterotopia
Various degrees of intensity and locations of epilepsy are associated with malformations of cortical development. Researchers suggest that approximately 40% of children diagnosed with drug-resistant epilepsy have some degree of cortical malformation.Lissencephaly (to which pachygyria is most closely linked) is associated with severe mental retardation, epilepsy, and motor disability. Two characteristics of lissencephaly include its absence of convolutions (agyria) and decreased presence of convolutions (pachygyria).
Ophiasis is a form of alopecia areata characterized by the loss of hair in the shape of a wave at the circumference of the head.It gets its name from Greek ὄφις ophis snake because of the apparent similarity to a snake-shape and the pattern of hair loss.The term "sisaipho" is used to characterize the inverse pattern. Sisaipho is, almost, the reverse spelling of ophiasis. It is also called "ophiasis inversus".This form of hair loss "...targets the bodys own hair follicles, resulting in hair loss..." and although the immune system could be attacking hair follicle melanocytes, dermal papilla cells, and keratinocytes,” the foundational cause of this disease is yet to be confirmed. Pattern of hair loss
This is one among many types of patterns of hair loss, “in which they have band-link hair loss across the occiput.” Hair loss can take the form of patches of hair being removed and there can also be spontaneous regrowth as well. Duration of hair loss
Ophiasis hair loss is one form in which the hair loss can further deteriorate and can extend “for more than a year.”

References
External links

Cheng Tan, MD; Wen-Wuan Zhu, MD. "Mosaic Hair Regrowth Pattern of Ophiasis and Androgenic Alopecia in a Patient With Alopecia Areata Totalis". Medscape. {{cite web}}:  CS1 maint: uses authors parameter (link)