Risankizumab, sold under the brand name Skyrizi, is a humanized monoclonal antibody targeting interleukin 23A (IL-23A). Risankizumab is part of a collaboration between Boehringer Ingelheim and AbbVie. Risankizumab has been approved in the European Union, the United States, and Canada for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy, and moderate to severe Crohns disease in the United States. In Japan, it is approved for treating plaque psoriasis, generalized pustular psoriasis, erythrodermic psoriasis and psoriatic arthritis in adults who have an inadequate response to conventional therapies. Clinical trials
Psoriasis
In a phase I clinical trial, thirty-nine patients received single-dose risankizumab, eighteen of which received the drug intravenously, thirteen subcutaneously, and eight received the placebo drug. There were several instances that adverse effects occurred but in the same frequency for the placebo and the experimental groups. Four serious adverse events occurred in the risankizumab treated patients, all of which were judged not treatment related. Risankizumab was associated with clinical improvement in individuals treated with the drug, from week 2 and maintained for up to 66 weeks after treatment. At week 12 of treatment, 75%, 90%, and 100% decreases in the Psoriasis Area and Severity Index (PASI) were achieved by 87%, 58%, and 16% of risankizumab treated patients, regardless of dose, respectively, versus individuals receiving placebo.
Videx, Inc. is a Corvallis, Oregon manufacturer of computer hardware such as access control products and data collection terminals. Its initial success came with the first release of the $345 Videoterm (80 column) display card in March 1980 and the $149 shift and custom keyboard mapping Enhancer II terminal card in November 1981, both for Apple II computers. Later, in 1984, it released its $379 UltraTerm expansion card boasting high-definition 96-pixel characters and up to 128 × 32 character display. These products became obsolete when Apple released the Apple IIe with most of the 80-column card hardware built-in - only a much simpler and cheaper RAM card was then required. Videx also produced software, including Desktop Calendar for the Apple Lisa. References
External links
Official website