Rocky Mountain spotted fever was first identified in the 1800s in the Rocky Mountains. Signs and symptoms
Spotted fever can be very difficult to diagnose in its early stages, due to the similarity of symptoms with many different diseases.People infected with R. rickettsii usually notice symptoms following an incubation period of one to two weeks after a tick bite. The early clinical presentation of Rocky Mountain spotted fever is nonspecific and may resemble a variety of other infectious and noninfectious diseases. Initial symptoms:
Fever
Nausea
Emesis (vomiting)
Severe headache
Muscle pain
MalaiseLater signs and symptoms:
Maculopapular rash
Petechial rash
Abdominal pain
Joint pain
Conjunctivitis
ForgetfulnessThe classic triad of findings for this disease are fever, rash, and history of tick bite. However, this combination is often not identified when patients initially present for care. The rash has a centripetal, or "inward" pattern of spread, meaning it begins at the extremities and courses towards the trunk. Rash
The rash first appears two to five days after the onset of fever, and it is often quite subtle. Younger patients usually develop the rash earlier than older patients. Most often the rash begins as small, flat, pink, nonitchy spots (macules) on the wrists, forearms, and ankles. These spots turn pale when pressure is applied and eventually become raised on the skin. The characteristic red, spotted (petechial) rash of Rocky Mountain spotted fever is usually not seen until the sixth day or later after onset of symptoms, but this type of rash occurs in only 35 to 60% of patients with Rocky Mountain spotted fever.
It most commonly develops between the ages of ten and twenty. Females typically are more severely affected than males with a ratio of 4:1. The term is from Ancient Greek: σκολίωσις, romanized: skoliosis which means "a bending". Signs and symptoms
Symptoms associated with scoliosis can include:
Pain in the back, shoulders, neck, ribs and buttock pain nearest the bottom of the back
Respiratory or cardiac problems in severe cases
Constipation due to curvature causing "tightening" of the stomach, intestines, etc. Limited mobility secondary to pain or functional limitation in adults mostly when twisting the torso.The signs of scoliosis can include:

Uneven musculature on one side of the spine
Rib prominence or a prominent shoulder blade, caused by rotation of the rib cage in thoracic scoliosis
Uneven hips, arms, or leg lengths
Slow nerve action
Uneven posture
Heart and lung problems in severe cases
Calcium deposits in the cartilage endplate and sometimes in the disc itself

Course
People who have reached skeletal maturity are less likely to have a worsening case. Some severe cases of scoliosis can lead to diminishing lung capacity, pressure exerted on the heart, and restricted physical activities.Recent longitudinal studies reveal that the most common form of the condition, late-onset idiopathic scoliosis, causes little physical impairment other than back pain and cosmetic concerns, even when untreated, with mortality rates similar to the general population. Older beliefs that untreated idiopathic scoliosis necessarily progresses into severe (cardiopulmonary) disability by old age have been refuted by later studies.