Pagets disease of bone (commonly known as Pagets disease or, historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. The affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone formation. These structural changes cause the bone to weaken, which may result in deformity, pain, fracture or arthritis of associated joints.The exact cause is unknown, although leading theories indicate both genetic and acquired factors (see Causes). Pagets disease may affect any one or several bones of the body (most commonly pelvis, tibia, femur, lumbar vertebrae, and skull), but never the entire skeleton, and does not spread from bone to bone. Rarely, a bone affected by Pagets disease can transform into a malignant bone cancer. As the disease often affects people differently, treatments of Pagets disease can vary. Although there is no cure for Pagets disease, medications (bisphosphonates and calcitonin) can help control the disorder and lessen pain and other symptoms. Medications are often successful in controlling the disorder, especially when started before complications begin. Pagets disease affects from 1.5 to 8.0 percent of the population, and is most common in those of British descent. It is primarily diagnosed in older people and is rare in people less than 55 years of age. Men are more commonly affected than women (3:2). The disease is named after English surgeon Sir James Paget, who described it in 1877.
Baritosis is a benign type of pneumoconiosis, which is caused by long-term exposure to barium dust. Barium has a high radio-opacity and the disease may develop after few months of exposure. Extremely dense, discrete small opacities of 2–4 mm diameter, sometimes of a star-like configuration, are seen on the radiograph. Their distribution is uniform. When they are very numerous, superimposition may give the impression of confluency, but this does not seem to occur in reality. The hilar lymph nodes can be very opaque but not enlarged. After cessation of exposure, there is a gradual clearing of the opacities. Symptoms and signs
Cough
Wheezing
Nasal irritationIn some cases, it is asymptomatic. Diagnosis
The barium particles can be seen as opaque shadows on the chest X-rays of people with baritosis. However, being a benign condition, it neither interferes with lung function nor causes symptoms other than a mild cough.After exposure to barium dust ceases, the X-ray abnormalities gradually resolve. Treatment
Reference

http://www.wrongdiagnosis.com/b/baritosis/intro.htm


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