Clotrimazole/betamethasone dipropionate, sold under the brand name Lotrisone among others, is a topical medication used for the treatment of fungal infections of the feet, groin, and body in people 17 years of age and older. It is a combination of clotrimazole and betamethasone dipropionate. It is applied to the skin.Common side effects include paresthesia, rash, edema, and secondary infections.In 2019, it was the 366th most commonly prescribed medication in the United States, with more than 600 thousand prescriptions. Medical uses
Clotrimazole/betamethasone dipropionate is indicated for the topical treatment of symptomatic inflammatory tinea pedis, tinea cruris, and tinea corporis due to Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum in people 17 years of age and older. Society and culture
Legal status
Clotrimazole/betamethasone dipropionate cream was approved for medical use in the United States in July 1984, and the lotion was approved for use in the United States in December 2000. References
External links
"Betamethasone dipropionate mixture with Clotrimazole". Drug Information Portal. U.S. National Library of Medicine. "Betamethasone Topical: MedlinePlus Drug Information". MedlinePlus. "Clotrimazole Topical: MedlinePlus Drug Information". MedlinePlus.
An externally attached leech will detach and fall off on its own accord when it is satiated on blood, which may take from twenty minutes to a few hours; bleeding from the wound may continue for some time. Internal attachments, such as inside the nose, are more likely to require medical intervention.Bacteria, viruses, and protozoan parasites from previous blood sources can survive within a leech for months, so leeches could potentially act as vectors of pathogens. Nevertheless, only a few cases of leeches transmitting pathogens to humans have been reported.Leech saliva is commonly believed to contain anaesthetic compounds to numb the bite area, but this has never been proven. Although morphine-like substances have been found in leeches, they have been found in the neural tissues, not the salivary tissues. They are used by the leeches in modulating their own immunocytes and not for anaesthetising bite areas on their hosts. Depending on the species and size, leech bites can be barely noticeable or they can be fairly painful. In human culture
The leech appears in Proverbs 30:15 as an archetype of insatiable greed. More generally, a leech is a persistent social parasite or sycophant.The medicinal leech Hirudo medicinalis, and some other species, have been used for clinical bloodletting for at least 2,500 years: Ayurvedic texts describe their use for bloodletting in ancient India.