This is mainly a problem with producing speech. They have trouble finding the right words, but mostly they have a difficulty coordinating the muscles they need to speak. Eventually, someone with NFA-PPA only uses one-syllable words or may become totally mute. A frontotemporal dementia associated with amyotrophic lateral sclerosis (ALS) known as (FTD-ALS) includes the symptoms of FTD (behavior, language and movement problems) co-occurring with amyotrophic lateral sclerosis (loss of motor neurons). Two FTD-related disorders are progressive supranuclear palsy (also classed as a Parkinson-plus syndrome), and corticobasal degeneration. These disorders are tau-associated. Huntingtons disease
Huntingtons disease is a neurodegenerative disease caused by mutations in a single gene HTT, that encodes for huntingtin protein. Symptoms include cognitive impairment and this usually declines further into dementia.The first main symptoms of Huntingtons disease often include:

difficulty concentrating
memory lapses
depression - this can include low mood, lack of interest in things, or just abnormal feelings of hopelessness
stumbling and clumsiness that is out of the ordinary
mood swings, such as irritability or aggressive behavior to insignificant things

HIV
HIV-associated dementia results as a late stage from HIV infection, and mostly affects younger people. The essential features of HIV-associated dementia are disabling cognitive impairment accompanied by motor dysfunction, speech problems and behavioral change. Cognitive impairment is characterised by mental slowness, trouble with memory and poor concentration. Motor symptoms include a loss of fine motor control leading to clumsiness, poor balance and tremors. Behavioral changes may include apathy, lethargy and diminished emotional responses and spontaneity.
7p22.1 microduplication syndrome (also called Trisomy 7p22.1) is a newly discovered genetic disorder which is characterized by cranial and facial dysmorphisms, intellectual disability, and motor-speech delays. It is caused by a duplication of the p22.1 region of chromosome 7. Signs and symptoms
The symptoms of this syndrome are (but are not limited to) cranio-facial dysmorphisms such as macrocephaly, frontal bossing, low-set ears, hypertelorism, etc., intellectual disabilities, speech and motor delays, and heart, ocular, renal and skeletal defects (such as patent foramen ovale {heart} or brachydactyly type D {skeletal} ). Causes
This condition (as the name implies) is caused by a 430 kB duplication of the p22.1 region of chromosome 7. This mutation is autosomal recessive , meaning that a baby would need 1 copy of a mutated gene from both parents in order to show symptoms of the disorder. Epidemiology
Only 60 cases of 7q22.1 microduplication syndrome have been recorded in medical literature


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