Test results should, therefore, always be interpreted using the reference range from the laboratory that produced the result. Using the molecular weight of 362.460 g/mole, the conversion factor from µg/dL to nmol/L is approximately 27.6; thus, 10 µg/dL is about 276 nmol/L. Cortisol follows a circadian rhythm, and to accurately measure cortisol levels is best to test four times per day through saliva. An individual may have normal total cortisol but have a lower than normal level during a certain period of the day and a higher than normal level during a different period. Therefore, some scholars question the clinical utility of cortisol measurement.Cortisol is lipophilic, and is transported bound to transcortin (also known as corticosteroid-binding globulin) and albumin, while only a small part of the total serum cortisol is unbound and has biological activity. Serum cortisol assays measures total cortisol, and its results may be misleading for patients with altered serum protein concentrations. The salivary cortisol test avoids this problem because only free cortisol can pass through the salivary barrier. Transcortin particles are too large to pass through this barrier.Automated immunoassays lack specificity and show significant cross-reactivity due to interactions with structural analogs of cortisol, and show differences between assays. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) can improve specificity and sensitivity.
A unibrow (or jacco brow or monobrow; called synophrys in medicine) is a single eyebrow created when the two eyebrows meet in the middle above the bridge of the nose. The hair above the bridge of the nose is of the same color and thickness as the eyebrows, such that they converge to form one uninterrupted line of hair. History
The word monobrow first appeared in print in 1968, and the adjectival form monobrowed followed in 1973, in Martin Amis novel The Rachel Papers. The first known use of the word unibrow was in 1981. Culture and beauty
Oman
A unibrow is considered as a sign of beauty by Baluchi Omanis. Its popularity causes women to draw a black line joining the brows as a part of their routine makeup to fake a unibrow. A study found the prevalence of synophrys to be at 11.87% in the Omani population. Tajikistan
In Tajikistan, a unibrow is viewed as an attractive quality in both men and women. For women, it is associated with virginity and purity and, in men, virility. If there is no unibrow present, or if it is weak, it is commonplace for women to use a kohl liner or a modern kajal pen to simulate a unibrow. Elsewhere
The unibrow has largely been seen as undesirable in the Americas and Europe, with the hairs often plucked, shaved, or waxed away. The artist Frida Kahlo was famous for her unibrow, which she often depicted in self-portraits.