Athletes foot, known medically as tinea pedis, is a common skin infection of the feet caused by a fungus. Signs and symptoms often include itching, scaling, cracking and redness. In rare cases the skin may blister. Athletes foot fungus may infect any part of the foot, but most often grows between the toes. The next most common area is the bottom of the foot. The same fungus may also affect the nails or the hands. It is a member of the group of diseases known as tinea.Athletes foot is caused by a number of different fungi, including species of Trichophyton, Epidermophyton, and Microsporum. The condition is typically acquired by coming into contact with infected skin, or fungus in the environment. Common places where the fungi can survive are around swimming pools and in locker rooms. They may also be spread from other animals. Usually diagnosis is made based on signs and symptoms; however, it can be confirmed either by culture or seeing hyphae using a microscope.Athletes foot is not limited to just athletes: it can be caused by going barefoot in public showers, letting toenails grow too long, wearing shoes that are too tight, and not changing socks daily. It can be treated with topical antifungal medications such as clotrimazole or, for persistent infections, using oral antifungal medications such as terbinafine. Topical creams are typically recommended to be used for four weeks. Keeping infected feet dry and wearing sandals also assists with treatment.Athletes foot was first medically described in 1908.
The β-lactam antibiotic resistance is due to the secretion β-lactamase a protein that destroys antibiotics. If the bacteria cannot secrete the β-lactamase, then the antibiotic will be effective. The drug has been successfully used in the treatment of granulomatous amoebic encephalitis in conjunction with more conventional amoebicidal medications. References
Further reading
Dean L (2017). "Thioridazine Therapy and CYP2D6 Genotypes". In Pratt VM, McLeod HL, Rubinstein WS,  et al. (eds.). Medical Genetics Summaries. National Center for Biotechnology Information (NCBI). PMID 28520378. Bookshelf ID: NBK424018. External links
"Thioridazine". Drug Information Portal. U.S. National Library of Medicine. Antipsychotic Mellaril Removed from Market Schizophrenia Daily News Blog.