Sensitivity reactions: Urticaria, rash, pruritus and eosinophilia in white blood cell counts
Other locations/body as a whole: Lower back pain, myalgia, arthralgia, fever, sweating, various cardiac arrhythmias, and hypotension

Pregnancy
The WHO states praziquantel is safe during pregnancy. Animal studies have failed to reveal evidence of fetal harm. Praziquantel is effective in reducing schistosomiasis during pregnancy. Another trial found that treatment with praziquantel did not increase the rates of low birthweight, fetal death, or congenital anomalies. Drug interactions
The antibiotic rifampicin decreases plasma concentrations of praziquantel.Carbamazepine and phenytoin are reported to reduce the bioavailability of praziquantel. Chloroquine also reduces its bioavailability.The drug cimetidine heightens praziquantel bioavailability. Mechanism of action
The drugs mode of action is not exactly known at present, but experimental evidence indicates praziquantel increases the permeability of the membranes of schistosome cells towards calcium ions. The drug thereby induces contraction of the parasites muscle, resulting in paralysis in the contracted state. The dying parasites are dislodged from their site of action in the host organism and may enter systemic circulation or may be destroyed by host immune reaction (phagocytosis). Additional mechanisms including focal disintegrations and disturbances of oviposition (laying of eggs) are seen in other types of sensitive parasites. Another hypothesis regarding the mechanism of action is that it interferes with adenosine uptake in worms. This effect may have therapeutical relevance given that the schistosome, as the Taenia and the Echinococcus (other praziquantel-sensitive parasites), is unable to synthesize purines, such as adenosine, de novo. Bayers Animal Health Division website states, "Praziquantel is active against cestodes (tapeworms).
Kaicide (Taiwan)
Milbemax (combination with milbemycin oxime) (Novartis) for veterinary use
Popantel (Jurox)
PraziPro (Hikari) for aquarium use
Praz-Tastic (NFP/National Fish Pharmaceuticals) for aquarium use
Pure Prazi (COTS Koi/Children of the Sun Koi) for aquarium use
PraziPure (J.K.O., Inc. d/b/a Kodama Koi Farm & Kodama Koi Garden; licensed by COTS Koi) for aquarium use
Profender (combination with emodepside) (Bayer) for veterinary use
Tape Worm Tabs (Trade Winds) for veterinary use
Zentozide (Berich (Thailand) Co)

Regulatory approval
Praziquantel is on the World Health Organizations List of Essential Medicines.Praziquantel is not licensed for use in humans in the UK, but it can be imported when necessary on a named-patient basis. It is available in the UK as a veterinary anthelmintic. Praziquantel is FDA approved in the US for the treatment of schistosomiasis and liver flukes, although it is effective in other infections. Veterinary medicine
Salmon poisoning disease
Diplozoon paradoxum and other Trematoda infections of many fish speciesIt may cause problems in dogs with MDR1 mutations. See also
Fenbendazole
Oxfendazole
Nocodazole

References
External links

"Praziquantel (Rx) Biltricide". Medscape. WebMD. Retrieved 2015-11-01. "Praziquantel". Drug Information Portal. U.S. National Library of Medicine.