Aerosolized formulations of amiloride have been tested in clinical trials, though long-term clinical trials have failed to show much utility. Due to its short duration of action, it was thought that longer-acting ENaC inhibitors may prove more effective. However, longer-acting ENaC inhibitors (i.e. benzamil) have also failed clinical trials, despite an improvement in both the solubility and potency of the drugs. A third generation amiloride analogue (N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate, research name "552-02"), with better pharmacokinetic properties, is being studied. Pain induced by exposure to acid is attenuated by amiloride in human trials, which may indicate a role for amiloride in the treatment of pain in the future. References
External links
 Media related to Amiloride at Wikimedia Commons
"Amiloride". Drug Information Portal. U.S. National Library of Medicine.
Median raphe cysts are a cutaneous condition of the penis due to developmental defects near the glans. : 682

See also
Cutaneous columnar cyst
List of cutaneous conditions


== References ==