These genes are located at 7q21.2 (chromosome 7 long arm), 7p13 (chromosome 7 short arm) and 3q25.2-q27 (chromosome 3 long arm) respectively. These lesions are further discussed in the Online Mendelian Inheritance in Man site – the reference numbers are OMIM 116860, OMIM 603284 and OMIM 603285 respectively. Variations
Cerebral cavernomas
Cavernous hemangiomas located in the brain or spinal cord are referred to as cerebral cavernomas or more usually as cerebral cavernous malformations (CCMs), and can be found in the white matter, but often abut the cerebral cortex. When they contact the cortex, they can represent a potential seizure focus for the patient. Unlike other cavernous hemangiomas, there is no tissue within the malformation and its borders are not encapsulated. Therefore, they can change in size and number over time. Liver cavernous hemangioma
Cavernous hemangiomas are erroneously called the most common benign tumors of the liver. Usually one malformation exists, but multiple lesions can occur in the left or right lobe of the liver in 40% of patients. Their sizes can range from a few millimeters to 20 centimetres. Those over 5 cm are often referred to as giant hemangiomas. These lesions are better classified as venous malformations. Eye cavernous hemangioma
In the eye, it is known as orbital cavernous hemangioma and is found in women more frequently than men, most commonly between the ages of 20–40. This neoplasm is usually located within the muscle cone, which is lateral to the optic nerve. It is not usually treated unless the patient is symptomatic.
In geometry, a torus (plural tori, colloquially donut or doughnut) is a surface of revolution generated by revolving a circle in three-dimensional space about an axis that is coplanar with the circle. If the axis of revolution does not touch the circle, the surface has a ring shape and is called a torus of revolution. If the axis of revolution is tangent to the circle, the surface is a horn torus. If the axis of revolution passes twice through the circle, the surface is a spindle torus. If the axis of revolution passes through the center of the circle, the surface is a degenerate torus, a double-covered sphere. If the revolved curve is not a circle, the surface is a related shape, a toroid. Real-world objects that approximate a torus of revolution include swim rings, inner tubes and ringette rings. Eyeglass lenses that combine spherical and cylindrical correction are toric lenses.A torus should not be confused with a solid torus, which is formed by rotating a disk, rather than a circle, around an axis. A solid torus is a torus plus the volume inside the torus. Real-world objects that approximate a solid torus include O-rings, non-inflatable lifebuoys, ring doughnuts, and bagels. In topology, a ring torus is homeomorphic to the Cartesian product of two circles: S1 × S1, and the latter is taken to be the definition in that context. It is a compact 2-manifold of genus 1.