Paromomycin may have dangerous reactions when used with the paralytic succinylcholine by increasing its neuromuscular effects.There are no known food or drink interactions with paromomycin. Mechanism
Paromomycin is a protein synthesis inhibitor in nonresistant cells by binding to 16S ribosomal RNA. This broad-spectrum antibiotic soluble in water, is very similar in action to neomycin. Antimicrobial activity of paromomycin against Escherichia coli and Staphylococcus aureus has been shown. Paromomycin works as an antibiotic by increasing the error rate in ribosomal translation. Paromomycin binds to a RNA loop, where residues A1492 and A1493 are usually stacked, and expels these two residues. These two residues are involved in detection of correct Watson-Crick pairing between the codon and anti codon. When correct interactions are achieved, the binding provides energy to expel the two residues. Paromomycin binding provides enough energy for residue expulsion and thus results in the ribosome incorporating the incorrect amino acid into the nascent peptide chain. Pharmacokinetics
Absorption
GI absorption is poor. Any obstructions or factors which impair GI motility may increase the absorption of the drug from the digestive tract. In addition, any structural damage, such as lesions or ulcerations, will tend to increase drug absorption.For intramuscular (IM) injection, the absorption is rapid. Paromomycin will reach peak plasma concentration within one hour following IM injection. The in-vitro and in-vivo activities parallel those of neomycin. Elimination
Almost 100% of the oral dose is eliminated unchanged via feces. Any absorbed drug will be excreted in urine.
Perihepatitis is inflammation of the serous or peritoneal coating of the liver. Perihepatitis is often caused by one of the inflammatory disorders of the female upper genital tract, known collectively as pelvic inflammatory disease. Some patients have sharp right upper abdominal quadrant pain. One of the complications of perihepatitis is Fitz-Hugh–Curtis syndrome.Common bacterial causes for this disease are Chlamydia trachomatis and Neisseria gonorrhoeae. == References ==