By definition, it occurs in children at or greater than 2 years of age who acquired the infection trans-placentally.Symptoms include:
Blunted upper incisor teeth known as Hutchinsons teeth
Deafness from auditory nerve disease
Frontal bossing (prominence of the brow ridge)
Hard palate defect
Inflammation of the cornea known as interstitial keratitis
Protruding mandible
Saber shins
Saddle nose (collapse of the bony part of nose)
Short maxillae
Swollen kneesA frequently-found group of symptoms is Hutchinsons triad, which consists of Hutchinsons teeth (notched incisors), keratitis and deafness and occurs in 63% of cases.Treatment (with penicillin) before the development of late symptoms is essential. Signs and symptoms
Abnormal x-rays
Anemia
Cerebral palsy
Du Bois sign, narrowing of the little finger
Enlarged liver
Enlarged spleen
Frontal bossing
Sensorineural hearing loss
Higouménakis sign, enlargement of the sternal end of clavicle in late congenital syphilis
Hutchinsons triad, a set of symptoms consisting of deafness, Hutchinsons teeth (centrally notched, widely spaced peg-shaped upper central incisors), and interstitial keratitis (IK), an inflammation of the cornea which can lead to corneal scarring and potential blindness
Hydrocephalus
Jaundice
Lymph node enlargement
Mulberry molars (permanent first molars with multiple poorly developed cusps)
Musculoskeletal deformities
Petechiae
Poorly developed maxillae
Pseudoparalysis
Rhagades, linear scars at the angles of the mouth and nose result from bacterial infection of skin lesions
Snuffles, aka "syphilitic rhinitis", which appears similar to the rhinitis of the common cold, except it is more severe, lasts longer, often involves bloody rhinorrhea, and is often associated with laryngitis
Sabre shins
Skin rashDeath from congenital syphilis is usually due to bleeding into the lungs. Diagnosis
Serological testing is carried out on the mother and the infant.
Oxycodone in combination with naloxone in managed-release tablets, has been formulated to both deter abuse and reduce "opioid-induced constipation". Dependence and withdrawal
The risk of experiencing severe withdrawal symptoms is high if a patient has become physically dependent and discontinues oxycodone abruptly. Medically, when the drug has been taken regularly over an extended period, it is withdrawn gradually rather than abruptly. People who regularly use oxycodone recreationally or at higher than prescribed doses are at even higher risk of severe withdrawal symptoms. The symptoms of oxycodone withdrawal, as with other opioids, may include "anxiety, panic attack, nausea, insomnia, muscle pain, muscle weakness, fevers, and other flu-like symptoms".Withdrawal symptoms have also been reported in newborns whose mothers had been either injecting or orally taking oxycodone during pregnancy. Hormone levels
As with other opioids, chronic use of oxycodone (particularly with higher doses) often causes concurrent hypogonadism (low sex hormone levels). Overdose
In high doses, overdoses, or in some persons not tolerant to opioids, oxycodone can cause shallow breathing, slowed heart rate, cold/clammy skin, pauses in breathing, low blood pressure, constricted pupils, circulatory collapse, respiratory arrest, and death.In 2011, it was the leading cause of drug-related deaths in the U.S. However, from 2012 onwards, heroin and fentanyl have become more common causes of drug-related deaths.Oxycodone overdose has also been described to cause spinal cord infarction in high doses and ischemic damage to the brain, due to prolonged hypoxia from suppressed breathing. Interactions
Oxycodone is metabolized by the enzymes CYP3A4 and CYP2D6.