The release of adrenaline due to emotionally stressful events, which is endogenous adrenaline, can modulate memory consolidation of the events, ensuring memory strength that is proportional to memory importance. Post-learning adrenaline activity also interacts with the degree of arousal associated with the initial coding. There is evidence that suggests adrenaline does have a role in long-term stress adaptation and emotional memory encoding specifically. Adrenaline may also play a role in elevating arousal and fear memory under particular pathological conditions, including post-traumatic stress disorder. Overall, "Extensive evidence indicates that epinephrine (EPI) modulates memory consolidation for emotionally arousing tasks in animals and human subjects." Studies have also found that recognition memory involving adrenaline depends on a mechanism that depends on β adrenoceptors. Adrenaline does not readily cross the blood-brain barrier, so its effects on memory consolidation are at least partly initiated by β adrenoceptors in the periphery. Studies have found that sotalol, a β adrenoceptor antagonist that also does not readily enter the brain, blocks the enhancing effects of peripherally administered adrenaline on memory. These findings suggest that β adrenoceptors are necessary for adrenaline to have an impact on memory consolidation. Pathology
Increased adrenaline secretion is observed in pheochromocytoma, hypoglycemia, myocardial infarction, and to a lesser degree, in essential tremor (also known as benign, familial, or idiopathic tremor). A general increase in sympathetic neural activity is usually accompanied by increased adrenaline secretion, but there is selectivity during hypoxia and hypoglycemia, when the ratio of adrenaline to noradrenaline is considerably increased.
Other trials where the accused were condemned as Flagellants were recorded as late as the 1480s. The practice of flagellation within the bounds of the Catholic Church continued as an accepted form of penance. Rulers like Catherine de Medici and Frances King Henry III supported Flagellants but Henry IV banned them. Flagellant orders like Hermanos Penitentes (Spanish Penitential Brothers) also appeared in colonial Spanish America, even against the specific orders of Church authorities. In Italy
The first recorded cases of mass popular flagellation occurred in Perugia, in 1259. The prime cause of the Perugia episode is unclear, but it followed an outbreak of an epidemic and chroniclers report how mania spread throughout almost all the people of the city. Thousands of citizens gathered in great processions, singing and with crosses and banners, they marched throughout the city whipping themselves. It is reported that surprising acts of charity and repentance accompanied the marchers. However, one chronicler noted that anyone who did not join in the flagellation was accused of being in league with the devil. They also killed Jews and priests who opposed them. Marvin Harris links them to the Messianic preaching of Gioacchino da Fiore. Similar processions occurred across Northern Italy, with groups up to 10,000 strong  processing in Modena, Bologna, Reggio and Parma. Although certain city authorities refused the Flagellant processions entry. A similar movement arose again in 1399, again in Northern Italy in the form of the White Penitents or Bianchi movement.