Historically, the therapeutic potential of factitious airs, notably carbon monoxide as hydrocarbonate, was investigated by Thomas Beddoes, James Watt, Tiberius Cavallo, James Lind, Humphry Davy, and others in many labs such as the Pneumatic Institution. Signs and symptoms
On average, exposures at 100 ppm or greater is dangerous to human health. In the United States, the OSHA limits long-term workplace exposure levels to less than 50 ppm averaged over an 8-hour period; in addition, employees are to be removed from any confined space if an upper limit ("ceiling") of 100 ppm is reached. Acute poisoning
The main manifestations of carbon monoxide poisoning develop in the organ systems most dependent on oxygen use, the central nervous system and the heart. The initial symptoms of acute carbon monoxide poisoning include headache, nausea, malaise, and fatigue. These symptoms are often mistaken for a virus such as influenza or other illnesses such as food poisoning or gastroenteritis. Headache is the most common symptom of acute carbon monoxide poisoning; it is often described as dull, frontal, and continuous. Increasing exposure produces cardiac abnormalities including fast heart rate, low blood pressure, and cardiac arrhythmia; central nervous system symptoms include delirium, hallucinations, dizziness, unsteady gait, confusion, seizures, central nervous system depression, unconsciousness, respiratory arrest, and death. Less common symptoms of acute carbon monoxide poisoning include myocardial ischemia, atrial fibrillation, pneumonia, pulmonary edema, high blood sugar, lactic acidosis, muscle necrosis, acute kidney failure, skin lesions, and visual and auditory problems.
$4.15 billion of new commitments were made to tackle hunger at a June 2013 Hunger Summit held in London, hosted by the governments of Britain and Brazil, together with The Childrens Investment Fund Foundation.Despite the hardship caused by the 2007–2009 financial crisis and global increases in food prices that occurred around the same time, the UNs global statistics show it was followed by close to year on year reductions in the numbers suffering from hunger around the world. By 2019 however, evidence had mounted that this progress seemed to have gone into reverse over the last four years. The numbers suffering from hunger had risen both in absolute terms and very slightly even as a percentage of the worlds population.In 2019, FAO its annual edition of The State of Food and Agriculture which asserted that food loss and waste has potential effects on food security and nutrition through changes in the four dimensions of food security: food availability, access, utilization and stability. However, the links between food loss and waste reduction and food security are complex, and positive outcomes are not always certain. Reaching acceptable levels of food security and nutrition inevitably implies certain levels of food loss and waste. Maintaining buffers to ensure food stability requires a certain amount of food to be lost or wasted. At the same time, ensuring food safety involves discarding unsafe food, which then is counted as lost or wasted, while higher-quality diets tend to include more highly perishable foods.