Those with a history of recent infection that also have a spontaneous and full resolution of their cryoglobulinemia need no further treatment. Individuals without a history of infection and not showing resolution of their cryoglobulinemia need to be further evaluated. Their cryoglobulins should be analyzed for their composition of immunoglobulin type(s) and complement component(s) and examined for the presence of the premalignant and malignant diseases associated with Type I disease as well as the infectious and autoimmune diseases associated with type II and type III disease. A study conducted in Italy on >140 asymptomatic individuals found five cases of hepatitis C-related and one case of hepatitis b-related cryoglobulinemia indicating that a complete clinical examination of asymptomatic individuals with cryoglobulinemia offers a means for finding people with serious but potentially treatable and even curable diseases. Individuals who show no evidence of a disease underlying their cryoglobulinemia and who remain asymptomatic should be followed closely for any changes that may indicate development of cryoglobulinemic disease. Severely symptomatic cryoglobulinemic disease
People affected by the severest, often life-threatening, complications of cryoglobulinemic disease require urgent plasmapharesis and/or plasma exchange in order to rapidly reduce the circulating levels of their cryoglobulins.
Siti or SITI may refer to:

People
Siti (given name), a common Malay female given name
Siti Kassim (born 1961), Comorian politician
Siti Mwinyi (born 1932), Tanzanian first lady
Beáta Siti (born 1973), Hungarian handball player and coach
Eszter Siti (born 1977), Hungarian handball player
Walid Siti (born 1952), Kurdish artist
Siti Badriah (born 1991), musical artist Dancedhut at the Productions Nagaswara

Places
Siti Hydroelectric Power Station (disambiguation)

Other
Siti, character in Opera Jawa
Saratoga International Theater Institute, theater  company in New York, United States
SITI: An Iconic Exhibition of Dato Siti Nurhaliza
Siti (film), 2014 Indonesian film
Siti Networks
Siti language
Stevens Institute of Technology International, former private university in Dominican Republic

See also
All pages with titles containing Siti
All pages with titles beginning with Siti