This condition may also be due to the change in the chromosome affecting the transcription of genes. Other hypertrichosis patterns
Porphyria cutanea tarda may manifest in some patients as hypertrichosis on the face (mainly on top of the cheeks). Medical conditions
Acquired hypertrichosis lanuginosa is commonly present with cancer. This condition is also linked to metabolic disorders, such as anorexia, hormone imbalances, such as hyperthyroidism, or as a side effect of certain drugs.Acquired generalized hypertrichosis may be caused by cancer. The resulting hair growth is known as malignant down. The mechanism behind cancer induced hypertrichosis is unknown. Oral and topical minoxidil treatments are also known to cause acquired generalized hypertrichosis. Medications
Several medications can cause generalized or localized acquired hypertrichosis including:

Anticonvulsants: phenytoin
Immunosuppressants: cyclosporine
Vasodilators: diazoxide and minoxidil
Antibiotics: streptomycin
Diuretics: acetazolamide
Photosensitizers: PsoralenThe acquired hypertrichosis is usually reversible once these medications are discontinued. Other
Unknown causes
The exact genetic mutation that causes congenital circumscribed, localized, and nevoid hypertrichosis is unknown. Pathophysiology
A number of mechanisms can lead to hypertrichosis. One cause involves areas of the skin that are transforming from the small vellus type to the larger terminal type. This change normally occurs during adolescence, when vellus hair follicles in the underarms and groin grow into terminal hair follicles. Hypertrichosis involves this same type of switching, but in areas that do not normally produce terminal hair. The mechanisms for this switch are poorly understood.Another mechanism involves a change in the hair cycle.
On the contrary, hairy men and women with hypertrichosis are not necessarily isolated and they often live in courts as entertainers, together with other monster-like subjects. History
The first recorded case of hypertrichosis was Petrus Gonsalvus of the Canary Islands. This was documented by Ulisse Aldrovandi and published in his posthumous Monstrorum Historia cum Paralipomenis historiae omnium animalium in 1642. He noted that two daughters, a son, and a grandchild in Gonsalvus family all had hypertrichosis. Altrovandus dubbed them the Ambras family, after Ambras Castle near Innsbruck, where portraits of the family were found. During the next 300 years, about 50 cases  were observed. The scientist Rudolf Virchow described a form of hypertrichosis accompanied by gingival hyperplasia in 1873.In summer 2019, at least 17 Spanish children have developed so-called “werewolf syndrome”, Spains health ministry has said. Instead of being treated with omeprazole, a drug that helps with gastric reflux, they had received a treatment of minoxidil, a medication against hair loss. How the laboratory FarmaQuimica Sur, based in Malaga, made the mistake, is not yet clear. The lab has been closed as a precaution. In animals
The  condition is also sometimes found in cats. A male Persian with the condition named Atchoum achieved a certain level of notice due to the unusual appearance his hypertrichosis gave him, and has been nicknamed "The Werewolf Cat".In 1955, a female Müllers Bornean gibbon was obtained from Sarawak that exhibited abnormal hair growth in the facial region.