Intermittent neurogenic claudication characterized by lower limb numbness, weakness, diffuse or radicular leg pain associated with paresthesia (bilaterally), weakness and/or heaviness in buttocks radiating into lower extremities with walking or prolonged standing. Symptoms occur with extension of spine and are relieved with spine flexion. Minimal to zero symptoms when seated or supine. Radiculopathy (with or without radicular pain) neurologic condition—nerve root dysfunction causes objective signs such as weakness, loss of sensation and of reflex. Cauda equina syndrome - Lower extremity pain, weakness, numbness that may involve perineum and buttocks, associated with bladder and bowel dysfunction. Lower back pain due to degenerative disc or joint changes. Causes
Aging
Any of the factors below may cause the spaces in the spine to narrow. Spinal ligaments can thicken (ligamenta flava)
Bone spurs develop on the bone and into the spinal canal or foraminal openings
Intervertebral discs may bulge or herniate into the canal or foraminal openings
Degenerative disc disease causes narrowing of the spaces. Facet joints break down
Facet joints may hypertrophy
Compression fractures of the spine, which are common in osteoporosis
Synovial cysts form on the facet joints causing compression of the spinal sac of nerves (thecal sac)

Arthritis
Osteoarthritis
Rheumatoid arthritis—much less common cause of spinal problems

Congenital
Spinal canal is too small at birth
Structural deformities of the vertebrae may cause narrowing of the spinal canal. Instability of the spine
A vertebra slips forward on another (spondylolisthesis)

Trauma
Accidents and injuries may dislocate the spine and the spinal canal or cause burst fractures that yield fragments of bone that go through the canal.
Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare inherited disorder. Presentation
The primary manifestations are thrombocytopenia and megakaryocytopenia, or low numbers of platelets and megakaryocytes. There is an absence of megakaryocytes in the bone marrow with no associated physical abnormalities. Cause
The cause for this disorder appears to be a mutation in the gene for the TPO receptor, c-mpl, despite high levels of serum TPO. In addition, there may be abnormalities with the central nervous system including the cerebrum and cerebellum which could cause symptoms. Diagnosis
Treatment
The primary treatment for CAMT is bone marrow transplantation.Bone Marrow/Stem Cell Transplant is the only thing that ultimately cures this genetic disease. Frequent platelet transfusions are required to ensure that platelet levels do not fall to dangerous levels, although this is not always the case. It is known for patients to continue to create very small numbers of platelets over time. See also
Thrombopoietin
Myeloproliferative leukemia virus oncogene

References
External links
Amegakaryocytic Thrombocytopenia research study of Inherited Bone Marrow Failure Syndromes (IBMFS)