For this reason, discontinuation is often achieved through an extended regimen of slowly decreasing doses over a period of weeks or even months. Alternatively, the patient may be switched to a longer-acting gabaergic agent such as diazepam (in a manner similar to the use of methadone therapy for opiate addiction) before attempting tapering. While an acute cerebral edema is widely believed to be the initial cause of actor and martial artist Bruce Lees death in 1973, another factor which may have compounded and thereby contributed to Lee’s death, was his decision to take Equagesic (a brand which combined meprobamate and aspirin). "In the January 2008 issue of Drug Safety Update, a stop press article announced the recent European review of carisoprodol for which the Committee for Medicinal Products for Human Use concluded that the risks of treatment outweigh the benefits. This review was triggered by concerns from the Norwegian Medical Agency that carisoprodol (converted to meprobamate after administration) was associated with increased risk of abuse, addiction, intoxication, and psychomotor impairment." February 2008.The European Medicines Agency recommended suspension of marketing authorisations for meprobamate-containing medicines in the European Union in January 2012. Synthesis
Meprobamate, 2-methyl-2-propyl-1,3-propanediol dicarbamate is synthesized by the reaction of 2-methylvaleraldehyde with two molecules of formaldehyde and the subsequent transformation of the resulting 2-methyl-2-propylpropan-1,3-diol into the dicarbamate via successive reactions with phosgene and ammonia. See also
2-Methyl-2-propyl-1,3-propanediol
Carisoprodol
Lorbamate
Pentabamate
Phenprobamate
Mothers Little Helper (song)

References
External links
List of psychotropic substances under international control. The Comparative Toxicogenomics Database: Meprobamate. RxList.com - Meprobamate
Ethinylestradiol/levonorgestrel (EE/LNG) is a combined birth control pill made up of ethinylestradiol, an estrogen and  levonorgestrel a progestin. It is used for birth control, symptoms of menstruation, endometriosis, and as emergency contraception. It is taken by mouth. Some preparations of EE/LNG additionally contain an iron supplement in the form of ferrous bisglycinate or ferrous fumarate.Side effects can include nausea, headache, blood clots, breast pain, depression, and liver problems. Use is not recommended during pregnancy, the initial three weeks after childbirth, and in those at high risk of blood clots. However, it may be started immediately after a miscarriage or abortion. Smoking while using combined birth control pills is not recommended. It works by stopping ovulation, making the mucus at the opening to the cervix thick, and making the uterus not suitable for implantation.Ethinylestradiol/levonorgestrel has been approved for medical use in the United States at least since 1982. It is on the World Health Organizations List of Essential Medicines. It is available as a generic medication. It is marketed under a large number of brand names. In 2019, it was the 124th most commonly prescribed medication in the United States, with more than 5 million prescriptions. See also
Birth control pill formulations
List of combined sex-hormonal preparations


== References ==