Taken together, flutamide appears to be a considerably less potent and efficacious antiandrogen than is bicalutamide.Dose-ranging studies of flutamide in men with benign prostatic hyperplasia and prostate cancer alone and in combination with a GnRH agonist have been performed.Flutamide increases testosterone levels by 5- to 10-fold in gonadally intact male rats. CYP17A1 inhibition
Flutamide and hydroxyflutamide have been found in vitro to inhibit CYP17A1 (17α-hydroxylase/17,20-lyase), an enzyme which is required for the biosynthesis of androgens. In accordance, flutamide has been found to slightly but significantly lower androgen levels in GnRH analogue-treated male prostate cancer patients and women with polycystic ovary syndrome. In a directly comparative study of flutamide monotherapy (375 mg once daily) versus bicalutamide monotherapy (80 mg once daily) in Japanese men with prostate cancer, after 24 weeks of treatment flutamide decreased dehydroepiandrosterone (DHEA) levels by about 44% while bicalutamide increased them by about 4%. As such, flutamide is a weak inhibitor of androgen biosynthesis. However, the clinical significance of this action may be limited when flutamide is given without a GnRH analogue to non-castrated men, as the medication markedly elevates testosterone levels into the high normal male range via prevention of AR activation-mediated negative feedback on the hypothalamic–pituitary–gonadal axis in this context. Other activities
Flutamide has been identified as an agonist of the aryl hydrocarbon receptor. This may be involved in the hepatotoxicity of flutamide. Pharmacokinetics
The absorption of flutamide is complete upon oral ingestion. Food has no effect on the bioavailability of flutamide.
The third umpire may also be used if the Umpire Decision Review System is available and a team wishes to dispute a call concerning a possible catch. Celebration
Before 2000, the Laws of Cricket defined a catch as being completed when the player had "complete control over the further disposal of the ball". In the very strictest sense, this meant that the player did not finish catching the ball until he threw it away, though the player doesnt have to throw the ball to anyone in particular in so doing. For this reason, even today many cricketers celebrate a catch by lobbing the ball into the air. In a Super Sixes match in the 1999 Cricket World Cup, South African Herschelle Gibbs caught Australian captain Steve Waugh but Waugh was given not out when Gibbs was ruled to not have control of the ball when attempting to throw the ball in celebration. Waugh went on to score a match-winning 120 not out to qualify his team for the semi-finals; Australia went on to win the tournament. Records
Test matches
The wicket-keepers with the highest number of catches taken in Test matches are as follows. Note this excludes catches made while not fielding as a wicket-keeper. Source:  Cricinfo Statsguru. Last updated: 19 April 2019. The non-wicket-keepers with the highest number of catches taken in Test matches are as follows. Note this excludes any catches made while fielding as a wicket-keeper. Source:  Cricinfo Statsguru. Last updated: 19 April 2019.