It is a rare congenital stationary cone dysfunction syndrome, affecting less than 1 in 100,000 individuals, and is characterized by the absence of L- and M-cone function. BCM results from mutations in a single red or red–green hybrid opsin gene, mutations in both the red and the green opsin genes or deletions within the adjacent LCR (locus control region) on the X chromosome. Green cone monochromacy (GCM), also known as M-cone monochromacy, is a condition where the blue and red cones are absent in the fovea. The prevalence of this type of monochromacy is estimated to be less than 1 in 1 million. Red cone monochromacy (RCM), also known as L-cone monochromacy, is a condition where the blue and green cones are absent in the fovea. Like GCM, the prevalence of RCM is also estimated at less than 1 in 1 million.Cone Monochromats with normal rod function can sometimes exhibit mild color vision due to conditional dichromacy. In mesopic conditions, both rods and cones are active and opponent interactions between the cones and rods can afford slight color vision.According to Jay Neitz, a color vision researcher at the University of Washington, each of the three standard color-detecting cones in the retina of trichromats can detect approximately 100 gradations of color. The brain can process the combinations of these three values so that the average human can distinguish about one million colors. Therefore, a monochromat would be able to distinguish about 100 colors. Mammals
Until the 1960s popular belief held that most mammals outside of primates were monochromats.
Vision is reduced to blacks, whites, and greys. Rod Monochromacy (Achromatopsia), when all three of the cones are non-functional and therefore photopic vision (and therefore color vision) is disabled.Monochromacy of photopic vision is a symptom of both Cone Monochromacy and Rod Monochromacy, so these two conditions are typically referred to collectively as monochromacy. Rod Monochromacy
Rod monochromacy (RM), also called congenital complete achromatopsia or total color blindness, is a rare and extremely severe form of an autosomal recessively inherited retinal disorder resulting in severe visual handicap. People with RM have a reduced visual acuity, (usually about 0.1 or 20/200), have total color blindness, photo-aversion and nystagmus. The nystagmus and photo-aversion usually are present during the first months of life, and the prevalence of the disease is estimated to be 1 in 30,000 worldwide. Since patients with RM have no cone function, they lack photopic vision, relying entirely on their rods and scotopic vision, which is necessarily monochromatic. They therefore cannot see any color but only shades of grey. Cone Monochromacy
Cone monochromacy (CM) is a condition defined by the exhibition of only one class of cones. A cone monochromat can have good pattern vision at normal daylight levels, but will not be able to distinguish hues. As humans typically exhibit three classes of cones, cone monochromats can hypothetically derive their photopic vision from any one of them, leading to three categories of cone monochromats:
Blue cone monochromacy (BCM), also known as S-cone monochromacy, is an X-linked cone disease.