This superstition is sometimes asserted to have originated among soldiers in the trenches of the First World War when a sniper might see the first light, take aim on the second and fire on the third.The phrase "Third times the charm" refers to the superstition that after two failures in any endeavor, a third attempt is more likely to succeed. This is also sometimes seen in reverse, as in "third man [to do something, presumably forbidden] gets caught".Luck, especially bad luck, is often said to "come in threes". Sports
In American and Canadian football, a field goal is worth three points. In association football:
For purposes of league standings, since the mid-1990s almost all leagues have awarded three points for a win. A team that wins three trophies in a season is said to have won a treble. A player who scores three goals in a match is said to have scored a hat-trick. In baseball:
A batter strikes out upon the third strike in any single batting appearance. Each teams half of an inning ends once the defense has recorded three outs (unless the home team has a walk-off hit in the ninth inning or any extra inning). In scorekeeping, "3" denotes the first baseman. In basketball:
Three points are awarded for a basket made from behind a designated arc on the floor. The "3 position" is the small forward. In bowling, three strikes bowled consecutively is known as a "turkey".
Additionally, the number of keratin-10 positive cells and HLA-DR expression was higher as compared to psoriasis. In ILVEN without associated psoriasis all T-cell subsets and cells expressing NK receptors were reduced as compared to psoriasis, except for CD45RA+ cells. In particular the density of CD8+, CD45RO+ and CD2+, CD94 and CD161 showed a marked difference between ILVEN without psoriasis and psoriasis itself. T cells relevant in the pathogenesis of psoriasis are markedly reduced in ILVEN without psoriasis as compared to psoriasis. Treatment
Reported treatments include topical agents, dermabrasion, cryotherapy, laser therapy, and surgical excision. These therapies have a high failure rate because of incomplete relief of symptoms, scarring, or recurrence. Though similar in appearance, ILVEN will not respond to therapies known to affect psoriasis. ILVEN can be very difficult to live with but can be treated. The most effective method is full-thickness excision of the lesion. CO2 Laser Surgery can resurface the skin to give a flat, smoother and more normal appearance, but does not remove the lesion. History
The condition later known as ILVEN was first described by Paul Gerson Unna in 1896. ILVEN appears very similar to psoriasis. However, it was not until 1971 that the disorder was described and clearly defined as a distinct entity by Altman and Mehregan in a case study of 25 patients. The Dupre and Christol described histopathological criteria in 1977. Epidemiology
ILVEN usually appears in infancy or early childhood. The condition is very rarely begun in adulthood. ILVEN occurs predominantly in females (female-male ratio, 4:1) with no racial predominance.