In May 2012, the Phase IIb/III trial Lux-Lung 1 came to the same conclusion.In January 2015, a Phase III trial in people with NSCLC suggested the drug extended life expectancy in stage IV NSCLC adenocarcinoma with EGFR Mutation type del 19-positive tumors, compared to cisplatin-based chemotherapy by a year (33 months vs. 21 months). It also shows strong activity against exon 18 mutations (particularly G719) and is currently the preferred EGFR-TKI therapy for exon 18 mutations (particularly G719x).Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from afatinib. Double-blind Phase III trials are under way to confirm or refute this finding. Her2-negative breast cancers showed limited or no response to the drug. Society and culture
Brand names
In Bangladesh under the trade name Afanix. References
External links
"Afatinib". Drug Information Portal. U.S. National Library of Medicine. "Afatinib dimaleate". Drug Information Portal. U.S. National Library of Medicine.
Diaphragmatic hernia is a defect or hole in the diaphragm that allows the abdominal contents to move into the chest cavity. Treatment is usually surgical. Types
Congenital diaphragmatic hernia
Morgagnis hernia
Bochdalek hernia
Hiatal hernia
Iatrogenic diaphragmatic hernia
Traumatic diaphragmatic hernia

Signs and symptoms
A scaphoid abdomen (sucked inwards) may be the presenting symptom in a newborn. Diagnosis
Diagnosis can be made by either CT or X-ray. Treatment
Treatment for a diaphragmatic hernia usually involves surgery, with acute injuries often repaired with monofilament permanent sutures. Other animals
Peritoneopericardial diaphragmatic hernia is a type of hernia more common in other mammals. This is usually treated with surgery. References
Bibliography
Eren S, Ciris F (2005). "Diaphragmatic hernia: diagnostic approaches with review of the literature". Eur J Radiol. 54 (3): 448–59. doi:10.1016/j.ejrad.2004.09.008. PMID 15899350. == External links ==