Epidemiology
The C2 fracture accounts for nearly 19% of spinal fractures and 55% of cervical fractures (in patients with head injury). Within C2 fractures, the hangmans fracture accounts for 23% of occurrences while the odontoid or dens fracture accounts for 55% of them. Society
Statistics from the AHRQ show that there were 12,532 hospital discharges from C2 fractures in the US during 2010. The mean healthcare costs were $17,015 and the "national bill" or the aggregate charges were $749,553,403. Only 460 in-hospital deaths related to the C2 fracture occurred. From 2000 to 2010, the number of discharges has increased from 4,875 to 12,532, almost a 250 percent increase. Mean health care costs went from $24,771 to $59,939. See also
Cervical fracture
Cervical vertebrae

References


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Individuals with this condition are perceived as socially most aggressive compared with people without anodontia (Shaw 1981). The occurrence of anodontia is less so than hypodontia which has a prevalence of 0.1-0.7% in primary teeth and 3–7.5% in permanent teeth. Signs and symptoms
The main sign of anodontia is when a child has not developed any of their permanent teeth by the age of 12. Another sign of anodontia can include the absence of baby teeth when the baby has reached 12 to 13 months.Symptoms that are associated with anodontia include: alopecia, lack of sweat glands, cleft lip or palate, and missing fingernails. Typically, these symptoms are seen because anodontia is typically associated with ectodermal dysplasia. In the rare case that ectodermal dysplasia is not present, anodontia will be caused from an unknown genetic mutation. Cause
Anodontia typically occurs with the presence of ectodermal dysplasia, which is a group of disorders where two or more ectodermally derived structures will have abnormal development. In the rare case that ectodermal dysplasia is not associated or present, anodontia will be caused by an unknown genetic mutation. Although no specific gene has been identified, there have been many different genes found to be associated with anodontia including EDA, EDAR, and EDARADD genes. Other genes such as MSX1, PAX9, IRF6, GREM2, AXIN2, LRP6, SMOC2, LTBP3, PITX2, and WNT10B. The WNT10A gene is considered to be the major gene involved in hypodontia and oligodontia. These genes are involved in hypodontia and oligodontia.