This rise in water level can cause extreme flooding in coastal areas particularly when storm surge coincides with spring tide, resulting in storm tides reaching up to 20 feet or more in some cases." Urban flooding
Catastrophic
Catastrophic riverine flooding is usually associated with major infrastructure failures such as the collapse of a dam, but they may also be caused by drainage channel modification from a landslide, earthquake or volcanic eruption. Examples include outburst floods and lahars. Tsunamis can cause catastrophic coastal flooding, most commonly resulting from undersea earthquakes. Causes
Upslope factors
The amount, location, and timing of water reaching a drainage channel from natural precipitation and controlled or uncontrolled reservoir releases determines the flow at downstream locations. Some precipitation evaporates, some slowly percolates through soil, some may be temporarily sequestered as snow or ice, and some may produce rapid runoff from surfaces including rock, pavement, roofs, and saturated or frozen ground. The fraction of incident precipitation promptly reaching a drainage channel has been observed from nil for light rain on dry, level ground to as high as 170 percent for warm rain on accumulated snow.Most precipitation records are based on a measured depth of water received within a fixed time interval. Frequency of a precipitation threshold of interest may be determined from the number of measurements exceeding that threshold value within the total time period for which observations are available. Individual data points are converted to intensity by dividing each measured depth by the period of time between observations.
Anastrozole, sold under the brand name Arimidex among others, is a medication used in addition to other treatments for breast cancer. Specifically it is used for hormone receptor-positive breast cancer. It has also been used to prevent breast cancer in those at high risk. It is taken by mouth.Common side effects of anastrozole include hot flashes, altered mood, joint pain, and nausea. Severe side effects include an increased risk of heart disease and osteoporosis. Use during pregnancy may harm the baby. Anastrozole is in the aromatase-inhibiting family of medications. It works by blocking the production of estrogens in the body, and hence has antiestrogenic effects.Anastrozole was patented in 1987 and was approved for medical use in 1995. It is on the World Health Organizations List of Essential Medicines. Anastrozole is available as a generic medication. In 2019, it was the 176th most commonly prescribed medication in the United States, with more than 3 million prescriptions. Medical uses
Breast cancer
Anastrozole is used in the treatment and prevention of breast cancer in women. The Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial was of localized breast cancer and women received either anastrozole, the selective estrogen receptor modulator tamoxifen, or both for five years, followed by five years of follow-up. After more than 5 years the group that received anastrozole had better results than the tamoxifen group. The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized estrogen receptor-positive breast cancer.