Relation to thin basement membrane disease
A thin glomerular basement membrane, as in thin basement membrane disease, is proposed to be the characteristic finding on renal biopsy, but not part of the syndrome definition. Differential diagnosis
Kidney stones
Nutcracker syndrome
IgA nephropathy
Cancer of the genitourinary tract
Chronic pelvic pain
Endometriosis
Pyelonephritis

Treatment
The treatment of LPHS varies considerably from centre to centre. As the condition is rare and poorly understood, a widely adopted standard of care is not existent.Treatment of loin pain-hematuria syndrome (LPHS) typically consists of pain management. Narcotics or oral opioids may be prescribed to help control pain. Patients with severe pain may need high-dose opioids daily or almost daily. Occasionally, people with LPHS require hospitalization for intravenous opioid therapy and control of nausea. Other treatments may include denervation, autotransplantation, renal neurectomy, or nephrectomy. Unfortunately symptoms often recur following these procedures. Limited evidence suggests that drugs that inhibit angiotensin may reduce the frequency and severity of episodes of loin pain and gross hematuria.Pain management with opiate and non-opiate analgesia is common.
Hepatic porphyrias is a form of porphyria in which toxic porphyrin molecules build up in the liver. Hepatic porphyrias can result from a number of different enzyme deficiencies.Examples include (in order of synthesis pathway):
Acute intermittent porphyria
Porphyria cutanea tarda and Hepatoerythropoietic porphyria
Hereditary coproporphyria
Variegate porphyria

See also
Erythropoietic porphyria
Givosiran

References
External links

Porphyrias,+Hepatic at the US National Library of Medicine Medical Subject Headings (MeSH)
www.drugs-porphyria.com
www.porphyria-europe.com