Treatment
There is no curative treatment. The disease remains progressive and fatal.Patients are managed according to what areas of the body are affected at a particular time. Enzymes, amino acids, antioxidants and vitamins have been used. Treatment for MELAS currently is 1. support the good mitochondria that is left with a mito cocktail and 2. avoid known mito toxins. Also the following supplements may help:

CoQ10 has been helpful for some MELAS patients. B complex 100 is recommended as the B vitamins are the energy vitamins. Nicotinamide has been used because complex l accepts electrons from NADH and ultimately transfers electrons to CoQ10. Riboflavin has been reported to improve the function of a patient with complex l deficiency and the 3250T-C mutation. The administration of L-arginine during the acute and interictal periods may represent a potential new therapy for this syndrome to reduce brain damage due to impairment of vasodilation in intracerebral arteries due to nitric oxide depletion. Citrulline is also used as citrulline makes the plasma arginine higher, these doses are being studied at Baylor. Treatment with IV arginine is thought to relax the blood vessels to the brain, via nitric oxide. https://jamanetwork.com/journals/jamaneurology/article-abstract/2499460

Epidemiology
The exact incidence of MELAS is unknown. It is one of the more common conditions in a group known as mitochondrial diseases. Together, mitochondrial diseases occur in about 1 in 4,000 people. See also
Mitochondrial myopathy

References
External links

melas at NIH/UW GeneTests
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