Paroxysmal extreme pain disorder originally named familial rectal pain syndrome, is a rare disorder whose most notable features are pain in the mandibular, ocular and rectal areas as well as flushing. PEPD often first manifests at the beginning of life, perhaps even in utero, with symptoms persisting throughout life. PEPD symptoms are reminiscent of primary erythromelalgia, as both result in flushing and episodic pain, though pain is typically present in the extremities for primary erythromelalgia. Both of these disorders have recently been shown to be allelic, both caused by mutations in the voltage-gated sodium channel NaV1.7 encoded by the gene SCN9A. A different mutation in "SCN9A" causes congenital insensitivity to pain. Symptoms and signs
The most distinctive feature of PEPD is episodic burning pain of the rectum, ocular, and mandibular regions. It should be stressed that while pain often originates or is centered in these areas it can also spread or be diffuse in nature. Pain experienced by patients with this disorder should not be underestimated as women with the disorder who have also given birth describe PEPD pain as worse than labor pain. Concomitant with this pain is typically flushing, often in an area associated with the pain.During attacks in infants, the child often looks startled or terrified and can scream inconsolably. These attacks can be precipitated by injections, defecation, wiping of the perineum, eating, or the consumption of oral medication.
Crushed may refer to:

"Crushed" (Ms. Marvel), a 2022 episode of the American television series Ms. Marvel
"Crushed" (Roland Lee Gift song) a 2009 single by Roland Lee Gift
"Crushed" (The Suite Life of Zack & Cody episode), an episode of the television show The Suite Life of Zack & Cody
"Crushed", a song by Limp Bizkit from the 1999 soundtrack album End of Days
"Crushed", a song by Eighteen Visions from the 2004 album Obsession
"Crushed", a song by Dala from the 2009 album Everyone Is Someone
"Crushed", a song by Parkway Drive from the 2015 album Ire
"Crushed", a song by Rosette Sharma

See also
Crush (disambiguation)
Crusher (disambiguation)
All pages with titles beginning with Crushed 
All pages with titles containing Crushed