Failure of neurologic, cardiac, renal, and gastrointestinal (GI) organs, as well as death, can occur unpredictably at any time, either very quickly or following prolonged symptomatic or asymptomatic disease progression. Cause
Typical HUS
STEC-HUS occurs after ingestion of a strain of bacteria expressing Shiga toxin such as enterohemorrhagic Escherichia coli (EHEC), of which E. coli O157:H7 is the most common serotype. Atypical HUS
Atypical HUS (aHUS) represents 5–10% of HUS cases and is largely due to one or several genetic mutations that cause chronic, uncontrolled, and excessive activation of the complement system, which is a group of immune signaling factors that promote inflammation, enhance the ability of antibodies and phagocytic cells to clear microbes and damaged cells from the body, and directly attack the pathogens cell membrane. This results in platelet activation, endothelial cell damage, and white blood cell activation, leading to systemic TMA, which manifests as decreased platelet count, hemolysis (breakdown of red blood cells), damage to multiple organs, and ultimately death. Early signs of systemic complement-mediated TMA include thrombocytopenia (platelet count below 150,000 or a decrease from baseline of at least 25%) and evidence of microangiopathic hemolysis, which is characterized by elevated LDH levels, decreased haptoglobin, decreased hemoglobin (the oxygen-containing component of blood), and/or the presence of schistocytes.
Like idiot savant, the term came to be considered a misnomer because only half of those who were diagnosed with savant syndrome were autistic. Upon realization of the need for accuracy of diagnosis and dignity towards the individual, the term savant syndrome became widely accepted terminology. Society and culture
Notable cases
Aleksander Vinter, known as "Savant", musician and producer
Daniel Tammet, British author and polyglot
Derek Paravicini, British blind musical prodigy and pianist
Henriett Seth F., Hungarian autistic writer and artist
Kim Peek, American "megasavant"
Leslie Lemke, American musician
Rex Lewis-Clack, American pianist and musical savant
Matt Savage, American musician
Stephen Wiltshire, British architectural artist
Temple Grandin, American professor of animal science
David M. Nisson, American scientist
Tom Wiggins, American blind pianist and composer
Tommy McHugh, British artist and poet
Kodi Lee, 2019 Americas Got Talent winner (musician)

Acquired cases
Alonzo Clemons, American acquired savant sculptor
Anthony Cicoria, American acquired savant pianist and medical doctor
Derek Amato, American composer and pianist, he has developed savant syndrome and synesthesia
Patrick Fagerberg, American acquired savant artist, inventor and former lawyer.