A proof of concept study of OCA (25 mg/d) has shown clinical and biochemical benefit. FDA Label Update
On February 1, 2018, the FDA updated label warnings for obeticholic acid to better explain recommended dosing. According to the agency, a misunderstanding led some health care professionals to improperly dose the drug on a daily basis rather than weekly, which can increase the risk of liver damage. References
External links
"Obeticholic acid". Drug Information Portal. U.S. National Library of Medicine.
A right bundle branch block (RBBB) is a heart block in the right bundle branch of the electrical conduction system.During a right bundle branch block, the right ventricle is not directly activated by impulses travelling through the right bundle branch. The left ventricle, however, is still normally activated by the left bundle branch. These impulses are then able to travel through the myocardium of the left ventricle to the right ventricle and depolarize the right ventricle this way. As conduction through the myocardium is slower than conduction through the Bundle of His-Purkinje fibres, the QRS complex is seen to be widened. The QRS complex often shows an extra deflection that reflects the rapid depolarisation of the left ventricle followed by the slower depolarisation of the right ventricle. Incomplete right bundle branch block
Incomplete right bundle branch block (IRBBB) is an conduction abnormality in the right bundle branch block. While a complete RBBB has a QRS duration of 120 ms or more, an incomplete block has a wave duration between 110 and 120 ms. It has a relatively high prevalence, a study conducted on young Swiss military conscripts with a mean age of 19 years found a prevalence of 13.5%. It affects patients of all ages, more commonly males and athletes, however is not always a benign finding. Therefore, if abnormalities are detected on the physical exam, further testing should be done to exclude heart disease.There is no consensus in the literature regarding criteria for diagnosis.