Nathalie syndrome is a rare genetic developmental defect during embryogenesis disorder and is thought to be hereditary.In 1975 a physician described four siblings in a Dutch family with symptoms of the condition; the condition was named after the oldest sibling.According to Orphanet, the condition occurs in 1 in 1 million people.Children with this condition appear younger than their age. Nathalie syndrome can cause disability and death around early or mid adulthood. Sudden death, cardiomyopathy, and heart failure have been reported in some cases. == References ==
Pharmacokinetics
It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretins half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least three years after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant. References
External links
"Acitretin". Drug Information Portal. U.S. National Library of Medicine.