A decrease in benzodiazepine binding sites in the brain may also occur as part of benzodiazepine tolerance. Cross tolerance
Benzodiazepines share a similar mechanism of action with various sedative compounds that act by enhancing the GABAA receptor. Cross tolerance means that one drug will alleviate the withdrawal effects of another. It also means that tolerance of one drug will result in tolerance of another similarly-acting drug. Benzodiazepines are often used for this reason to detoxify alcohol-dependent patients and can have life-saving properties in preventing or treating severe life-threatening withdrawal syndromes from alcohol, such as delirium tremens. However, although benzodiazepines can be very useful in the acute detoxification of alcoholics, benzodiazepines in themselves act as positive reinforcers in alcoholics, by increasing the desire for alcohol. Low doses of benzodiazepines were found to significantly increase the level of alcohol consumed in alcoholics. Alcoholics dependent on benzodiazepines should not be abruptly withdrawn but be very slowly withdrawn from benzodiazepines, as over-rapid withdrawal is likely to produce severe anxiety or panic, which is well known for being a relapse risk factor in recovering alcoholics.There is cross tolerance between alcohol, the benzodiazepines, the barbiturates, the nonbenzodiazepine drugs, and corticosteroids, which all act by enhancing the GABAA receptors function via modulating the chloride ion channel function of the GABAA receptor.Neuroactive steroids, e.g., progesterone and its active metabolite allopregnanolone, are positive modulators of the GABAA receptor and are cross tolerant with benzodiazepines.
In breastfeeding, lactation failure may refer to:

Primary lactation failure, a cause of low milk supply in breastfeeding mothers
Cessation of breastfeeding before the mother had planned to stop, usually as a result of breastfeeding difficulties
Low milk supply in generalLactation failure can result in neonatal jaundice. References

Lawrence, Ruth A. (1986). "Maternal Factors in Lactation Failure". Human Lactation 2. Boston, MA: Springer US. pp. 283–291. doi:10.1007/978-1-4615-7207-7_25. ISBN 978-1-4615-7209-1. Lawrence, Ruth (2016). Breastfeeding : a guide for the medical profession, 8th edition. Philadelphia, PA: Elsevier. p. 836. ISBN 978-0-323-35776-0. == External links ==