Long term, children can relapse several years after having no symptoms; though after 2 years, the risk is significantly lower.In most children with minimal change disease, particularly among those who respond typically, there is minimal to no permanent damage observed in their kidneys. Complications primarily arise from the side effects of therapy. Prolonged use of corticosteroids can lead to immunosuppression (leading to infection), growth complications, weight gain. Adults
While most adults diagnosed with minimal change disease  respond to corticosteroids, 25% fail to respond after 3–4 months of corticosteroid therapy; it is possible that these patients were incorrectly diagnosed, and do not have minimal change disease. Adults with MCD tend to respond more slowly to corticosteroid treatment, taking up to 3 or 4 months, than children do. Data in adults is less complete than for children, but relapses are fairly frequent with 56–76% of patients relapsing and needing further treatment with immunosuppressants such as ciclosporin, tacrolimus, mycophenolate, and rituximab. There is little evidence to support the use of azathioprine for MCD.As in children, complications primarily arise from the side effects of therapy. Prolonged use of corticosteroids can lead to immunosuppression (leading to infection), growth complications, weight gain. Epidemiology
Minimal change disease is most common in very young children but can occur in older children and adults.It is by far the most common cause of nephrotic syndrome in children, accounting for 70–90% of children >1 year of age. After puberty, it is caused by minimal change disease about half the time.
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External links

Medline Plus article on Nasal Discharge