In 1964, James Black synthesized the first clinically significant beta blockers—propranolol and pronethalol; it revolutionized the medical management of angina pectoris and is considered by many to be one of the most important contributions to clinical medicine and pharmacology of the 20th century.For the treatment of primary hypertension, meta-analyses of studies which mostly used atenolol have shown that although beta blockers are more effective than placebo in preventing stroke and total cardiovascular events, they are not as effective as diuretics, medications inhibiting the renin–angiotensin system (e.g., ACE inhibitors), or calcium channel blockers. Medical uses
Large differences exist in the pharmacology of agents within the class, thus not all beta blockers are used for all indications listed below.
Shake may refer to:

Handshake
Milkshake
Tremor
Shakes (wood), cracks in timber
Shake (shingle), a wooden shingle made from split logsShake, The Shakes, Shaking, or Shakin may refer to:

Geography
Shake, Zimbabwe
Shake, another name for Sake language, used in parts of Gabon

People
Shakin Stevens, Welsh rock and roll singer
Anthony "Shake" Shakir, Detroit techno producer
Master Shake, a character in Aqua Teen Hunger Force
Shake (singer) (Sheikh Abdullah Ahmad), Malaysian singer
Shaking, a stage name of Xie Keyin, Chinese singer, rapper and songwriter
Malik "Shake" Milton, American basketball player

Music
Shake (music) (more commonly known as a trill), a musical ornament
The Shake (dance), a fad dance of the 1960s
The Shake (American rock band)

Albums
Shake (The Thing album) (2015)
Shake (John Schlitt album) (1995)
Shake! (album) (1968), by the Siegel–Schwall Band
Shake (2001), by Zucchero Fornaciari
Shakin (album), 1986 work by country music group Sawyer Brown
The Shake (Laurie Johnson), an LP by Laurie Johnson, the base of what is now known as "The Avengers Theme"

Songs
"Shake" (Sam Cooke song) (1964), notably covered by Otis Redding
"Shake!"