A founder effect is also apparent in Sardinia, where there have been 18 recorded cases of Werner syndrome. Society and culture
On the episode "Stargazer in a Puddle" from the television series Bones, the victim has Werner syndrome. The team discovers in the course of the investigation that her mother killed her because she was dying of another disease, and worried that her daughter would have nobody to look after her afterwards, with the tragic twist that the mother began to recover from her disease after her daughters death.Werner syndrome is featured in the 1989 film The Fly II, starring Eric Stoltz, in which his character is born as a 2 year old baby. He never sleeps and grows 5 times his normal age due to his biological father having half fly genes from the first 1986 film The Fly.Werner syndrome is also featured in the 1996 film Jack, starring Robin Williams, in which his character ages four times faster than normal.In an early cutscene from the game Metal Gear Solid 4, Otacon cites "classic Werner syndrome" as the most likely cause of Solid Snakes premature aging, though he goes on to say that testing had been inconclusive.
A pervasive developmental disorder not otherwise specified (Including atypical autism) (PDD-NOS) is one of the four autistic spectrum disorders in the DSM-5 and also was one of the five disorders classified as a pervasive developmental disorder (PDD) in the DSM-IV. According to the DSM-4, PDD-NOS is a diagnosis that is used for "severe or pervasive impairment in the development of reciprocal social interaction and/or verbal and nonverbal communication skills, or when stereotyped behavior, interests, and/or activities are present, but the criteria are not met for a specific PDD" or for several other disorders. PDD-NOS includes atypical autism, because the criteria for autistic disorder are not met, for instance because of late age of onset, atypical symptomatology, or subthreshold symptomatology, or all of these. Even though PDD-NOS is considered milder than typical autism, this is not always true. While some characteristics may be milder, others may be more severe. Signs and symptoms
It is common for individuals with PDD-NOS to have more intact social skills and a lower level of intellectual deficit than individuals with other PDDs. Characteristics of many individuals with PDD-NOS are:

Communication difficulties (e.g., using and understanding language)
Difficulty with social behavior
Paranoia, a characteristic form of social anxiety, derealization, transient psychosis, and unconventional beliefs if the environment changed without further notice
Uneven skill development (strengths in some areas and delays in others)
Unusual play with toys and other objects
Repetitive body movements or behavior patterns
Preoccupation with fantasies that interfere and that are not normal to have at a certain age depending on social, cultural and religious norms.