Because it spreads from host to host through contamination, enterobiasis is common among people living in close contact, and tends to occur in all people within a household. The prevalence of pinworms is not associated with gender, nor with any particular social class, race, or culture. Pinworms are an exception to the tenet that intestinal parasites are uncommon in affluent communities. History
The earliest known instance of pinworms is evidenced by pinworm eggs found in coprolite, carbon dated to 7837 BC at western Utah. Pinworm infection is not classified as a neglected tropical disease unlike many other parasitic worm infections.Garlic has been used as a treatment in the ancient cultures of China, India, Egypt, and Greece. Hippocrates (459–370 BC) mentioned garlic as a remedy against intestinal parasites. German botanist Lonicerus (1564) recommended garlic against parasitic worms. Notes
References

External links

Brown MD (March 2006). "Images in clinical medicine. Enterobius vermicularis". The New England Journal of Medicine. 354 (13): e12. doi:10.1056/NEJMicm040931. PMID 16571876.
Plazomicin was found to be noninferior to meropenem. History
The drug was developed by the biotech company Achaogen. In 2012, the U.S. Food and Drug Administration granted fast track designation for the development and regulatory review of plazomicin. The FDA approved plazomicin for adults with complicated UTIs and limited or no alternative treatment options in 2018. Achaogen was unable to find a robust market for the drug, and declared bankruptcy a few months later. A generic version is manufactured by Cipla USA. Synthesis
It is derived from sisomicin by appending a hydroxy-aminobutyric acid substituent at position 1 and a hydroxyethyl substituent at position 6. The latter makes it impervious to acetylation (deactivation) by Aminoglycoside Acetyltransferase 6-N- Type Ib (AAC(6)-Ib), the most prevalent AAC enzyme. Names
Plazomicin is the international nonproprietary name (INN). References
Further reading
"FDA Briefing Information for the May 2, 2018 Meeting of the Antimicrobial Drugs Advisory Committee" (PDF). U.S. Food and Drug Administration. 2 May 2018. Retrieved 14 September 2019. "Achaogen Briefing Information for the May 2, 2018 Meeting of the Antimicrobial Drugs Advisory Committee" (PDF). U.S. Food and Drug Administration. 2 May 2018. Retrieved 14 September 2019. "Errata to the Achaogen Briefing Information for the May 2, 2018 Meeting of the Antimicrobial Drugs Advisory Committee" (PDF). U.S. Food and Drug Administration. 2 May 2018. Retrieved 14 September 2019. External links
"Plazomicin". Drug Information Portal. U.S. National Library of Medicine. "Plazomicin sulfate". Drug Information Portal. U.S. National Library of Medicine.