Although modest reversal of clozapine-associated weight gain is found with metformin, primary prevention of weight gain is more valuable. Use with insulin
Metformin may reduce the insulin requirement in type 1 diabetes, albeit with an increased risk of hypoglycemia. Life extension
There is some evidence metformin may be helpful in extending lifespan, even in otherwise healthy people. It has received substantial interest as an agent that delays aging, possibly through similar mechanisms as its treatment of diabetes (insulin and carbohydrate regulation). This is controversial, and an area of active research. Alzheimers disease
The possibility that metformin can delay the onset or progression of Alzheimers, or even prevent it, is under investigation. There has been a variety of research published in this field in an effort to establish a correlation between type 2 diabetes and Alzheimers disease. Research now includes studies with participants not diagnosed with diabetes. Contraindications
Metformin is contraindicated in people with:

Severe renal impairment (estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m2)
Known hypersensitivity to metformin
Acute or chronic metabolic acidosis, including diabetic ketoacidosis (from uncontrolled diabetes), with or without comaWarnings are also given regarding the use of metformin in less severe renal impairment, people aged 65 years old or greater,  hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, hepatic impairment, concomitant use of certain drugs (e.g.
Lichen aureus  is a skin condition characterized by the sudden appearance of one or several golden or rust-colored, closely packed macules or lichenoid papules. : 830

See also
Pigmentary purpuric eruptions
List of cutaneous conditions

References


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