The criteria for the diagnosis of NDPH were proposed in 1994 (the Silberstein–Lipton criteria)  but not included in the International Classification of Headache Disorders (ICHD) until 2004. Signs and symptoms
The headaches can vary greatly in their clinical presentation and duration.Quality of the headache has been described as dull and/or pressure-like sensation, and throbbing and/or pulsating sensation. The pain is usually on both sides of the head (in 88–93% of people with NDPH), but may be unilateral, and may be localized to any head region. The pain can fluctuate in intensity and duration, is daily, and lasts more than 3 months.There may be accompanying photophobia, phonophobia, lightheadedness or mild nausea. Co-morbidity with mood disorders has been reported in a subset of patients.Cranial autonomic nervous symptoms occur with painful exacerbations in 21%, and cutaneous allodynia may be present in 26%.In 2002, Li and Rozen conducted a study of 56 patients at the Jefferson Headache Center in Philadelphia and published the following results:

82% of patients were able to pinpoint the exact day their headache started. 30% of the patients, the onset of the headache occurred in correlation with an infection or flu-like illness. 38% of the patients had a prior personal history of headache. 29% of the patients had a family history of headache. 68% reported nausea. 66% reported photophobia. 61% reported phonophobia. 55% reported lightheadedness.Imaging and laboratory testing were unremarkable except for an unusually high number of patients who tested positive for a past Epstein-Barr virus infection.
Osteopathia striata with cranial sclerosis (OSCS) is a rare genetic entity characterized by osseous abnormalities. Signs and symptoms
Symptoms and their severity vary person to person but generally people with OSCS have generalized dysplasia of the distal parts of the long bones, cranial sclerosis (that is, the hardening of bones in the face and head), macrocephaly (abnormally large head), and cleft palate. Developmental delay, hearing loss, congenital heart defects, alongside feeding and breathing (dyspnea) difficulties are common as well, although they are not seen in all cases. Complications
The feeding and breathing difficulties that are sometimes associated with OSCS can result in starvation, nutritional deficiencies, and/or respiratory arrest if they remain untreated, which may result in early death. Treatment
Although OSCS has no cure, it can be treated and managed. Treatment is symptom-specific, for example: avoiding areas with air pollution (e.g., big cities, smoking areas, etc. ), high-altitude areas, and physically exhausting activities can reduce breathlessness episodes (breathing difficulties). Causes
This condition is caused by X-linked dominant mutations in the AMER1 gene, in the X chromosome. Prevalence
According to OMIM, the total number of cases described in medical literature is between 70 and 90. == References ==