Such therapies include insulin shock therapy, cardiazol shock therapy, and electroconvulsive therapy. Despite considerable risk, shock therapy was considered highly efficacious in the treatment of psychosis including schizophrenia. The acceptance of high-risk treatments led to more invasive medical interventions including psychosurgery. In 1888, Swiss psychiatrist Gottlieb Burckhardt performed the first medically sanctioned psychosurgery in which the cerebral cortex was excised. Although some patients showed improvement of symptoms and became more subdued, one patient died and several developed aphasia or seizure disorders. Burckhardt would go on to publish his clinical outcomes in a scholarly paper. This procedure was met with criticism from the medical community and his academic and surgical endeavors were largely ignored. In the late 1930s, Egas Moniz conceived the leucotomy (AKA prefrontal lobotomy) in which the fibers connecting the frontal lobes to the rest of the brain were severed. Monizs primary inspiration stemmed from a demonstration by neuroscientists John Fulton and Carlyles 1935 experiment in which two chimpanzees were given leucotomies and pre- and post-surgical behavior was compared. Prior to the leucotomy, the chimps engaged in typical behavior including throwing feces and fighting. After the procedure, both chimps were pacified and less violent. During the Q&A, Moniz asked if such a procedure could be extended to human subjects, a question that Fulton admitted was quite startling. Moniz would go on to extend the controversial practice to humans with various psychotic disorders, an endeavor for which he received a Nobel Prize in 1949.
Therefore, the use in pregnancy is not recommended. Side effects
The nasal spray form of mometasone may cause the following side effects:

headache
Viral upper respiratory infections
sore throat
nose bleeds
cough
muscle and joint painSerious side effects include: Thrush (fungal infection in the nose or throat), slow wound healing, eye problems such as glaucoma or cataracts, weakened immune system (immunodeficiency) which causes an increased susceptibility to infections and adrenal insufficiency. The inhaled form of mometasone for asthma may cause the following side effects

headache
stuffy or runny nose
dry throat
swelling of nose, throat and sinuses
flu like symptoms
painful menstrual periodsSerious side effects may include: allergic reactions (anaphylaxis), increased risk of osteoporosis, glaucoma and cataracts, thrush in the mouth or throat, growth retardation in children, bronchospasms, adrenal insufficiency and weakened immune system which causes an increased susceptibility to infections. The topical (skin cream) version may cause:

burning and itching at the application site
acne
changes in skin color
dryness at application site
skin soresThe only serious side effect that is known with mometasone topical is adrenal insufficiency. Pharmacology
Pharmacodynamics
Mometasone furoate reduces inflammation by causing several effects:
Reversing the activation of inflammatory proteins
Activating the secretion of anti-inflammatory proteins
Stabilizing cell membranes
Decreasing the influx of inflammatory cellsIn addition to the glucocorticoid properties of mometasone furoate, it is a very potent agonist of the progesterone receptor as well as a partial agonist of the mineralocorticoid receptor. Mechanism of action
Mometasone, like other corticosteroids, possesses anti-inflammatory, antipruritic, and vasoconstrictive properties. For allergies, corticosteroids reduce the allergic reactions in various types of cells (mastocytes and eosinophils) that are responsible for allergic reactions.