Enophthalmos is a posterior displacement of the eyeball within the orbit. It is due to either enlargement of the bony orbit and/or reduction of the orbital content, this in relation to each other.It should not be confused with its opposite, exophthalmos, which is the anterior displacement of the eye. It may be a congenital anomaly, or be acquired as a result of trauma (such as in a blowout fracture of the orbit), Horners syndrome (apparent enophthalmos due to ptosis), Marfan syndrome, Duanes syndrome, silent sinus syndrome or phthisis bulbi. References
Further reading
Cline RA, Rootman J (1984). "Enophthalmos: a clinical review". Ophthalmology. 91 (3): 229–37. doi:10.1016/s0161-6420(84)34299-3. PMID 6717910. == External links ==
Methotrexate based chemotherapy markedly improves survival, with some studies showing median survival after methotrexate chemotherapy reaching 48 months. In AIDS patients
Patients with AIDS and PCNSL have a median survival of only 4 months with radiotherapy alone. Untreated, median survival is only 2.5 months, sometimes due to concurrent opportunistic infections rather than the lymphoma itself. Extended survival has been seen, however, in a subgroup of AIDS patients with CD4 counts of more than 200 and no concurrent opportunistic infections, who can tolerate aggressive therapy consisting of either methotrexate monotherapy or vincristine, procarbazine, or whole brain radiotherapy. These patients have a median survival of 10–18 months. Of course, highly active antiretroviral therapy (HAART) is critical for prolonged survival in any AIDS patient, so compliance with HAART may play a role in survival in patients with concurrent AIDS and PCNSL. References
External links

MedPix Teaching File MR Scans of Primary Brain Lymphoma