The phenotypically aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells which in studied cases appears due to their excess production of interleukin 5, interleukin 3, or interleukin 13. The disorder is usually indolent but infrequently progresses to T-cell lymphoma or Sezary syndrome. Accumulation of partial deletions in the short arm of chromosome 6, the long arm of chromosome 10, or the acquirement of an extra chromosome (i.e. trisomy) 7) in T-cells or the proliferation of lymphocytes with the CD3 negative, CD41 positive immunophenotype may occur during the disorders progression to lymphoma. Reports on treatment of the disorder are rare. In on study of 16 lymphocyte-variant hypereosinophilia patients with the aberrant CD3 negative, CD41 positive immunophenotype, good responds to corticosteroid drugs were uniform but 16 ultimately required corticosteroid-sparing agents. Hydroxyurea and imatinib are less likely to have efficacy in this variant of hypereosinophilia than in many cases of clonal eosinophilia or chronic eosinophilic leukemia. Gleichs syndrome
Gleichs syndrome, which may be a form of lymphocyte-variant hypereosinophilia, involves hypereosinophilia, elevated blood levels of IgM antibodies, and clonal expansion of T cells. Similar to lymphocyte=variant hypereosinophilia, the increased levels of blood eosinophils in Gleichs syndrome is thought to be secondary to the secretion of eosinophil-stimulating cytokines by a T cell clones. IgG4-related disease
IgG4-related disease or Immunoglobulin G4-related disease is a condition dacryoadenitis, sialadenitis, lymphadentitis, and pancreatitis (i.e. inflammation of the lacrimal glands, salivary glands, lymph nodes, and pancreas, respectively) plus retroperitoneal fibrosis.
Patients were treated with sciatic nerve decompression by resection of fibrovascular scar bands, piriformis tendon release, obturator internus, or quadratus femoris or by hamstring tendon scarring. Anesthetic
Signals from the sciatic nerve and its branches can be blocked, in order to interrupt transmission of pain signal from the innervation area, by performing a regional nerve blockade called a sciatic nerve block. Society and culture
According to Jewish law, the sciatic nerve (Hebrew: Gid hanasheh) may not be eaten by Jews, to commemorate Jacobs  injury in his struggle with an angel. Additional images
See also
Lesser sciatic notch
Greater sciatic notch

Notes
References
This article incorporates text in the public domain from page 960 of the 20th edition of Grays Anatomy (1918)

External links
Sciatic nerve at the Duke University Health Systems Orthopedics program
MedlinePlus Image 19503
pelvis at The Anatomy Lesson by Wesley Norman (Georgetown University) (pelvicnerves)
glutealregion at The Anatomy Lesson by Wesley Norman (Georgetown University) (glutealner)
Sciatica and the Sciatic Nerve