In very rare cases, it causes severe side effects such as angioedema, anaphylaxis, and C. difficile infection (that can range from mild diarrhea to serious pseudomembranous colitis). Some develop black "furry" tongue. Serious adverse effects also include seizures and serum sickness. The most common side effects, experienced by about 10% of users are diarrhea and rash. Less common side effects can be nausea, vomiting, itching, and blood dyscrasias. The gastrointestinal effects, such as hairy tongue, nausea, vomiting, diarrhea, and colitis, are more common with the oral form of penicillin. Other conditions may develop up several weeks after treatment. Overdose
Ampicillin overdose can cause behavioral changes, confusion, blackouts, and convulsions, as well as neuromuscular hypersensitivity, electrolyte imbalance, and kidney failure. Interactions
Ampicillin reacts with probenecid and methotrexate to decrease renal excretion. Large doses of ampicillin can increase the risk of bleeding with concurrent use of warfarin and other oral anticoagulants, possibly by inhibiting platelet aggregation. Ampicillin has been said to make oral contraceptives less effective, but this has been disputed. It can be made less effective by other antibiotic, such as chloramphenicol, erythromycin, cephalosporins, and tetracyclines. For example, tetracyclines inhibit protein synthesis in bacteria, reducing the target against which ampicillin acts. If given at the same time as aminoglycosides, it can bind to it and inactivate it. When administered separately, aminoglycosides and ampicillin can potentiate each other instead.Ampicillin causes skin rashes more often when given with allopurinol.Both the live cholera vaccine and live typhoid vaccine can be made ineffective if given with ampicillin.
Gallbladder and sphincter of Oddi disorders

E1. Biliary pain
E1a. Functional gallbladder disorder
E1b. Functional biliary sphincter of Oddi disorder
E2. Functional pancreatic sphincter of Oddi disorderF. Anorectal disorders

F1. Fecal incontinence
F2. Functional anorectal pain
F2a. Levator ani syndrome
F2b. Unspecified functional anorectal pain
F2c. Proctalgia fugax
F3. Functional defecation disorders
F3a. Inadequate defecatory propulsion
F3b. Dyssynergic defecationG. Childhood functional GI disorders: Neonate/Toddler

G1. Infant regurgitation
G2. Rumination syndrome
G3. Cyclic vomiting syndrome (CVS)
G4. Infant colic
G5. Functional diarrhea
G6. Infant dyschezia
G7. Functional constipationH. Childhood functional GI disorders: Child/Adolescent

H1. Functional nausea and vomiting disorders
H1a. Cyclic vomiting syndrome (CVS)
H1b. Functional nausea and functional vomiting
H1b1. Functional nausea
H1b2. Functional vomiting
H1c. Rumination syndrome
H1d. Aerophagia
H2. Functional abdominal pain disorders
H2a. Functional dyspepsia
H2a1. Postprandial distress syndrome
H2a2. Epigastric pain syndrome
H2b. Irritable bowel syndrome (IBS)
H2c. Abdominal migraine
H2d. Functional abdominal pain ‒ NOS
H3. Functional defecation disorders
H3a. Functional constipation
H3b. Nonretentive fecal incontinence

Epidemiology
Functional gastrointestinal disorders are very common. Globally, irritable bowel syndrome and functional dyspepsia alone may affect 16–26% of the population. Research
There is considerable research into the causes, diagnosis and treatments for FGIDs. Diet, microbiome, genetics, neuromuscular function and immunological response all interact. A role for mast cell activation has been proposed as one of the factors. See also
Allergy
Food intolerance
Functional indigestion
Histamine intolerance

References


== External links ==