The same TSH concentration may have a different meaning whether it is used for diagnosis of thyroid dysfunction or for monitoring of substitution therapy with levothyroxine. Reasons for this lack of generalisation are Simpsons paradox and the fact that the TSH-T3 shunt is disrupted in treated hypothyroidism, so that the shape of the relation between free T4 and TSH concentration is distorted. Therapeutic
A synthetic drug called recombinant human TSH alpha (rhTSHα or simply rhTSH) or thyrotropin alfa (INN) is manufactured by Genzyme Corp under the trade name Thyrogen. It is used to manipulate endocrine function of thyroid-derived cells, as part of the diagnosis and treatment of thyroid cancer. History
In 1916, Bennett M. Allen and Philip E. Smith found that the pituitary contained a thyrotropic substance. References
External links

"Thyrotropin alfa". Drug Information Portal. U.S. National Library of Medicine. TSH at Lab Tests Online
MedlinePlus Encyclopedia: 003684
Thyrotropin at the US National Library of Medicine Medical Subject Headings (MeSH)
Lonapegsomatropin, sold under the brand name Skytrofa, is a human growth hormone used for the treatment of growth hormone deficiency. Lonapegsomatropin is a prodrug of somatropin.Lonapegsomatropin was approved for medical use in the United States in August 2021. Medical uses
Lonapegsomatropin is a growth hormone therapy indicated to treat growth hormone deficiency. References
Further reading
External links
"Lonapegsomatropin". Drug Information Portal. U.S. National Library of Medicine. Clinical trial number NCT02781727 for "A Phase 3 Trial of the Safety, Tolerability and Efficacy of TransCon hGH Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD)" at ClinicalTrials.gov