An asymptomatic angiomyolipoma that is growing larger than 3 cm is best treated with an mTOR inhibitor drug. Other renal complications spotted by imaging include polycystic kidney disease and renal cell carcinoma. Repeat chest HRCT in adult women every five to 10 years. Evidence of lymphangioleiomyomatosis (LAM) indicates more frequent testing. An mTOR inhibitor drug can help, though a lung transplant may be required. A 12-lead ECG should be performed every three to five years.The mTOR inhibitor everolimus was approved in the US for treatment of TSC-related tumors in the brain (subependymal giant cell astrocytoma) in 2010 and in the kidneys (renal angiomyolipoma) in 2012. Oral everolimus (rapalog) reduces tumour size, is effective in terms of response to skin lesions and does not increase the risk of adverse events. Everolimus also showed evidence of effectiveness at treating epilepsy in some people with TSC. In 2017, the European Commission approved everolimus for treatment of refractory partial-onset seizures associated with TSC.Neurosurgical intervention may reduce the severity and frequency of seizures in TSC patients. Embolization and other surgical interventions can be used to treat renal angiomyolipoma with acute hemorrhage. Surgical treatments for symptoms of lymphangioleiomyomatosis (LAM) in adult TSC patients include pleurodesis to prevent pneumothorax and lung transplantation in the case of irreversible lung failure.Other treatments that have been used to treat TSC manifestations and symptoms include a ketogenic diet for intractable epilepsy and pulmonary rehabilitation for LAM. Facial angiofibromas can be reduced with laser treatment and the effectiveness of mTOR inhibitor topical treatment is being investigated.
Cambridge University Press; 2010 [cited October 17, 2011]. ISBN 978-0521731690. Nazaretyan, A.P. (2007). Violence and Non-Violence at Different Stages of World History: A view from the hypothesis of techno-humanitarian balance. In: History & Mathematics. Moscow: KomKniga/URSS. pp. 127–48. ISBN 978-5484010011. External links

Violence prevention at World Health Organization
Violence prevention at Centers for Disease Control and Prevention
Violence prevention at American Psychological Association
World Report on Violence Against Children Archived 2016-01-11 at the Wayback Machine at Secretary-General of the United Nations
Hidden in Plain Sight: A statistical analysis of violence against children Archived 2017-11-15 at the Wayback Machine at UNICEF
Heat and Violence