When the condition occurs in the liver it usually does not cause symptoms, but some may experience pain in the upper right abdomen, a feeling of fullness after eating only a small amount of food, decreased appetite, nausea, or vomiting. Presentation
Cavernous hemangiomas can arise nearly anywhere in the body where there are blood vessels. They are sometimes described as resembling raspberries because of the appearance of bubble-like caverns. Unlike capillary hemangiomas, cavernous ones can be life-threatening and do not regress. Causes
Most cases of cavernomas are thought to be congenital; however they can develop over the course of a lifetime. While there is no definitive cause, research suggests that genetic mutations result in the condition. Congenital hemangiomas that appear on the skin are known as either vascular or red birthmarks. Familial cerebral cavernous malformations are known to occur. The mutations may be inherited in an autosomal dominant fashion or occur sporadically. Overall, familial disease is thought to be responsible for one-third to one-half of cases. In the US, approximately 50% of Hispanic patients with cerebral  cavernous malformations have a familial form. In contrast, the familiar form of the condition accounts for only 10 to 20% of cases in Caucasians. The reason for this difference is not presently known. Several genes – K-Rev interaction trapped 1 (ССМ1), Malcavernin (CCM2) and Programmed cell death protein 10 (ССМ3) – have been identified as having mutations thought to be related to these lesions.
A variant of eccrine spiradenoma which can be multiple on the scalp and can  coalesce to form a Turban tumour. In pathology, a cylindroma is a tumour with nests of cells that resemble a cylinder in cross section. Types include:

Dermal eccrine cylindroma, a benign tumour of the skin
Adenoid cystic carcinoma, a malignant tumour of the salivary gland

See also
CYLD cutaneous syndrome
List of cutaneous neoplasms associated with systemic syndromes


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