After absorption and circulation to the respiratory tract, benzonatate acts as a local anesthetic, decreasing the sensitivity of vagal afferent fibers and stretch receptors in the bronchi, alveoli, and pleura in the lower airway and lung. This dampens their activity and reduces the cough reflex. Benzonatate also has central antitussive activity on the cough center in central nervous system at the level of the medulla. However, there is minimal inhibition of the respiratory center at a therapeutic dosage. Pharmacokinetics
The antitussive effect of benzonatate begins within 15 to 20 minutes after oral administration and typically lasts between 3 and 8 hours.Benzonatate is hydrolyzed by plasma butyrylcholinesterase (BChE) to the metabolite 4-(butylamino)benzoic acid (BABA) as well as polyethylene glycol monomethyl esters. Like many other local anesthetic esters, the hydrolysis of the parent compound is rapid. There are concerns that those with pseudocholinesterase deficiencies may have an increased sensitivity to benzonatate as this hydrolysis is impaired, leading to increased levels of circulating medication. Chemical structure
Benzonatate is a butylamine, structurally related to other polyglycol ester local anesthetics such as procaine and tetracaine. The molecular weight of benzonatate is 603.7 g/mol. However, the reference standard for benzonatate is a mixture of n-ethoxy compounds, differing in the abundance of 7-9 repeating units, with an average molecular weight of 612.23 g/mol. There is also evidence that the compound is not uniform between manufacturers. Society and culture
Benzonatate was first made available in the U.S. in 1958 as a prescription medication for the treatment of cough in individuals over the age of 10.
A brother is a man or boy who shares one or more parents with another; a male sibling. The female counterpart is a sister. Although the term typically refers to a familial relationship, it is sometimes used endearingly to refer to non-familial relationships. A full brother is a first degree relative. Overview
The term brother comes from the Proto-Indo-European *bʰréh₂tēr, which becomes Latin frater, of the same meaning. Sibling warmth or affection between male siblings has been correlated to some more negative effects. In pairs of brothers, higher sibling warmth is related to more risk taking behaviour, although risk taking behaviour is not related to sibling warmth in any other type of sibling pair. The cause of this phenomenon in which sibling warmth is only correlated with risk taking behaviours in brother pairs still is unclear. This finding does, however, suggest that although sibling conflict is a risk factor for risk taking behaviour, sibling warmth does not serve as a protective factor. Some studies suggest that girls having an older brother delays the onset of menarche by roughly one year. Research also suggests that the likelihood of being gay increases with the more older brothers a man has. Some analyzers have suggested that a mans attractiveness to a heterosexual woman may increase with the more he resembles her brother, while his unattractiveness may increase the more his likeness diverges from her brother.