Intramuscular injections of 200 mg NETE once every 3 weeks have also been found to suppress spermatogenesis in men. Similarly, a single intramuscular injection of 50 mg NETE in combination with 5 mg estradiol valerate has been found to strongly suppress testosterone levels in men. Levels of testosterone decreased from ~503 ng/dL at baseline to ~30 ng/dL at the lowest point (–94%) which occurred at day 7 post-injection. Pharmacokinetics
The pharmacokinetics of norethisterone have been reviewed. Absorption
The oral bioavailability of norethisterone is between 47 and 73%, with a mean oral bioavailability of 64%. Micronization has been found to significantly improve the oral bioavailability of norethisterone by increasing intestinal absorption and reducing intestinal metabolism. A single 2 mg oral dose of norethisterone has been found to result in peak circulating levels of the drug of 12 ng/mL (40 nmol/L), whereas a single 1 mg oral dose of norethisterone in combination with 2 mg estradiol resulted in peak levels of norethisterone of 8.5 ng/mL (29 nmol/L) one-hour post-administration. Distribution
The plasma protein binding of norethisterone is 97%. It is bound 61% bound to albumin and 36% bound to SHBG. Metabolism
Norethisterone has an elimination half-life of 5.2 to 12.8 hours, with a mean elimination half-life of 8.0 hours. The metabolism of norethisterone is very similar to that of testosterone (and nandrolone) and is mainly via reduction of the Δ4 double bond to 5α- and 5β-dihydronorethisterone, which is followed by the reduction of the C3 keto group to the four isomers of 3,5-tetrahydronorethisterone.
Videx, Inc. is a Corvallis, Oregon manufacturer of computer hardware such as access control products and data collection terminals. Its initial success came with the first release of the $345 Videoterm (80 column) display card in March 1980 and the $149 shift and custom keyboard mapping Enhancer II terminal card in November 1981, both for Apple II computers. Later, in 1984, it released its $379 UltraTerm expansion card boasting high-definition 96-pixel characters and up to 128 × 32 character display. These products became obsolete when Apple released the Apple IIe with most of the 80-column card hardware built-in - only a much simpler and cheaper RAM card was then required. Videx also produced software, including Desktop Calendar for the Apple Lisa. References
External links
Official website