It was confirmed by an order in council on 1 April 1913 under King George V. The title reflects the fact that the archpriest has the right to sit beside the bishop and acknowledges no authority below that of the Archbishop of Canterbury, although today it is more appropriate to go through the usual channels of the churchs hierarchy. Haccombe is a village in Devon, near Newton Abbot, where the parish is combined with that of Stoke-in-Teignhead with Combe-in-Teignhead. There is an hereditary patron for the Church of St Blaise, Haccombe. The modern office most closely resembling that of archpriest is the role of rural dean (rural dioceses) or area dean (urban dioceses). Like the archpriest of old, these officers have supervisory duties, but not ordinary jurisdiction, and are entitled to carry out visitations of subordinate parishes when so commissioned. With this in mind, although the Archpriest of Haccombe holds a unique role in the Church of England, it is considered analogous with certain incumbencies which bear the title "Dean" regardless of whether or not their incumbent is the actual rural or area dean. One example of this historical oddity is the office of Dean of Bocking in Essex. The current Archpriest of St Blaise, Haccombe is the current incumbent, the Reverend Annie Church, the first female priest to hold this office in Haccombe.
In cases of milder disease the potential benefits of HCT (>90% probability of cure if transplant occurs before age two) must be considered in the context of non-trivial risks presented by the procedure itself and the potential need for lifelong immunosuppression to prevent graft-versus-host disease. Generally outcomes are better if HCT occurs prior to the development of autoimmune disease or malignancy, however there are risks associated with chemotherapy (needed to make room for the new stem cells) especially in young infants (risk of a second cancer, or infertility).Bleeding complications
Otherwise WAS treatment is focused on managing symptoms and preventing complications. The greatest mortality risk in WAS before age 30 is from bleeding so aspirin and other nonsteroidal anti-inflammatory drugs that may interfere with already compromised platelet function should generally be avoided. Circumcision, as well as elective surgeries, should generally be deferred in males with thrombocytopenia until after HCT if possible. Protective helmets can help protect children from life-threatening intracranial hemorrhage (brain bleed) which could result from head injuries. Patients may require platelet transfusions when there is extreme bloodloss (such as during surgery) or for very low platelets splenectomy (removal of the spleen) may also be lifesaving. However, splenectomy is generally considered palliative and is not universally recommended in WAS because it can increase the risk of life-threatening infections. Post-splenectomy patients will require lifelong antibiotic prophyllaxis to prevent infections.