The announcer then reminded the listener that Anacin was available "at any drug counter", and "comes in handy (tin) boxes of 12 and 30, and economical family-size bottles of 50 and 100", usually spelling out its name at the end of the commercial.Anacin sponsored the first made-for-television sitcom, Mary Kay and Johnny. Unsure of how many viewers would be watching when they sponsored the show in 1947, Anacin ran a simple test, offering a free mirror to the first 200 viewers to write for one. The offer drew over 9,000 responses, overwhelming the sponsor but proving television was a viable advertising medium.Anacin was also a leading sponsor of the television soaps Love of Life, The Secret Storm and the early years of The Young and the Restless. Anacin is one of the earliest and best examples of a concerted television marketing campaign, created for them in the late 1950s by Rosser Reeves of the Ted Bates ad agency. Many people remember the commercials advertising "tension producing" situations, and the "hammers in the head" advertisement with the slogan "Tension. Pressure. Pain." An Anacin advertisement in 1962 featured a mother trying to assist her grown daughter with various chores, such as preparing a meal. "Dont you think it needs a little salt? ", the mother would say, only to have her nerve-racked daughter shout, "Mother, please, Id rather do it myself!" As the mother wilted, the daughter would emote and rub her head, with her inner voice saying, "Control yourself!
This makes the sperm completely unable to penetrate the zona pellucida. The sperm in Type 2 globozoospermia has some acrosomal covering surrounded by large droplets of cytoplasmic material, suggesting secondary degenerative changes. There is also a conical nucleus. It is thought that infertility in this type of globozoospermia is due to incorrect chromatin packaging which prevents proper fertilization. Symptoms
Aside from the effect on fertility globozoospermia is symptomless. People with globozoospermia have normal physical and mental development, normal clinical features and normal hormonal profile. Genetics
Table 1: Gene mutations that have been identified in globozoospermia and the impact these mutations have on sperm function and successful fertilization. Diagnosis
The presence of round headed sperm in a semen analysis sample confirms the diagnosis of globozoospermia. The lack of acrosome can be ascertained by either morphology staining or immunofluorescence. Treatment
Until 1995, the only options for people with globozoospermia who wished to conceive were adoption or sperm donation. With the advancement of assisted reproductive techniques (ART) it is now possible for those with globozoospermia to conceive using their own sperm. The main technique used is intracytoplasmic sperm injection (ICSI) where fertilisation is achieved by a single sperm being injected into the egg. Some studies have shown it is possible for a viable embryo to be created with this technique alone, however others have found it necessary to also use calcium ionophore treatment for fertilisation to be successful. Calcium ionophore treatment is used to artificially activate the oocyte.