The cyclodextrin contained in the oral solution can cause an osmotic diarrhea, and if this is a problem, then half the dose can be given as oral solution and half as capsule to reduce the amount of cyclodextrin given. "Sporanox" itraconazole capsules should always be taken with food, as this improves absorption, however the manufacturers of "Lozanoc" assert that it may be taken "without regard to meals". Itraconazole oral solution should be taken an hour before food, or two hours after food (and likewise if a combination of capsules and oral solution are used). Itraconazole may be taken with orange juice or cola, as absorption is also improved by acid. Absorption of itraconazole is impaired when taken with an antacid, H2 blocker or proton pump inhibitor. Side effects
Itraconazole is a relatively well-tolerated drug (although not as well tolerated as fluconazole or voriconazole) and the range of adverse effects it produces is similar to the other azole antifungals:
elevated alanine aminotransferase levels are found in 4% of people taking itraconazole
"small but real risk" of developing congestive heart failure
liver failure, sometimes fatalThe cyclodextrin used to make the syrup preparation can cause diarrhea. Side effects that may indicate a greater problem include:

Interactions
The following drugs should not be taken with itraconazole:

Pharmacology
Pharmacodynamics
The mechanism of action of itraconazole is the same as the other azole antifungals: it inhibits the fungal-mediated synthesis of ergosterol, via inhibition of lanosterol 14α-demethylase.
The peritoneal cavity is a potential space between the  parietal peritoneum (the peritoneum that surrounds the abdominal wall) and visceral peritoneum (the peritoneum that surrounds the internal organs). The parietal and visceral peritonea are layers of the peritoneum named depending on their function/location. It is one of the spaces derived from the coelomic cavity of the embryo, the others being the pleural cavities around the lungs and the pericardial cavity around the heart. It is the largest serosal sac, and the largest fluid-filled cavity, in the body and secretes approximately 50 ml of fluid per day. This fluid acts as a lubricant and has anti-inflammatory properties. The peritoneal cavity is divided into two compartments – one above, and one below the transverse colon. Compartments
The peritoneal cavity is divided by the transverse colon (and its mesocolon) into an upper supracolic compartment, and a lower infracolic compartment. The liver, spleen, stomach, and lesser omentum are contained within the supracolic compartment. The small intestine surrounded by the ascending, transverse, and descending colon, and the paracolic gutters are contained within the infracolic compartment. Clinical significance
The peritoneal cavity is a common injection site, used in intraperitoneal injection. An increase in the capillary pressure in the abdominal viscera can cause fluid to leave the interstitial space and enter the peritoneal cavity, a condition called ascites.