Authors review the previous pathogenic theories, discuss the link between concentric sclerosis and Liesegangs periodic precipitation phenomenon and propose a new mechanism based on self-organization. Clinical courses
It that the clinical course is primary progressive, but a relapsing-remitting course has been reported. It seems that the course gets better with prednisone therapy, although evidence of this is anecdotal and such conclusions are difficult to accept given that there are cases where patients spontaneously recover whether the patient was on steroid therapy or not.Baló lesions can disappear over time, but it has also been reported that the disease can convert to RRMSThe clinical course of Balo-like lesions also depends to the context in which they appear. Balo-like lesions have been reported in aquaporin-4 seropositive and seronegative NMOSD, and also in children, as part of an ADEM-like presentation

Diagnosis
Lesions under MRI are distinctive due to their natural concentric shape.Under a lumbar puncture CSF test, with Balós concentric sclerosis, as well as patients with pattern III lesions, were recently shown to be mostly negative for CSF-restricted oligoclonal bands. Also pattern III patients tend to be negative under the MRZ-reaction (measles, rubeola and zoster viruses)

Paediatric cases
Balós concentric sclerosis in children has been reported to behave different from adults

Lesions in autopsy and biopsy
A report comparing 1H-magnetic resonance spectroscopy, magnetization transfer and diffusion tensor imaging with histopathology in a patient with Balós concentric sclerosis, found that inflammation was traced by fractional anisotropy and increased lactate.
Nature Clinical Practice Neurology. 3 (9): E1. doi:10.1038/ncpneuro0619. PMID 17805242. S2CID 33938721. == External links ==