Nineteen subjects (46%) who achieved a complete response continued to have a complete response at the twelve-month mark.The US Food and Drug Administration (FDA) granted the application for mitomycin gel priority review along with breakthrough therapy, fast track, and orphan drug designations. The FDA granted approval of Jelmyto to UroGen Pharma, Inc.

Research
Potential bis-alkylating heterocyclic quinones were synthetised in order to explore their antitumoral activities by bioreductive alkylation.In the bacterium Legionella pneumophila, mitomycin C induces competence, a condition necessary for the process of natural transformation that transfers DNA and promotes recombination between cells. Exposure of the fruitfly Drosophila melanogaster to mitomycin C increases recombination during meiosis, a key stage of the sexual cycle. It has been suggested that during sexual process in prokaryotes (transformation) and eukaryotes (meiosis) DNA cross-links and other damages introduced by mitomycin C may be removed by recombinational repair. See also
Aziridine

References
External links
"Mitomycin". Drug Information Portal. U.S. National Library of Medicine. Clinical trial number NCT02793128 for "The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study (Olympus)" at ClinicalTrials.gov
There is also evidence from a systematic review of randomized controlled trials that chewing gum, as a form of sham feeding, may stimulate gastrointestinal motility in the post-operative period and reduce the duration of postoperative ileus.If possible the underlying cause is corrected (e.g. replace electrolytes). Other animals
Ileus is a cause of colic in horses due to functional obstruction of the intestines. It is most commonly seen in horses postoperatively, especially following colic surgery. Horses experiencing ileus are at risk for gastric rupture due to rapid reflux build-up, and require intense medical management with frequent nasogastric intubation. Ileus may increase adhesion formation, because intestinal segments have more prolonged contact and intestinal distention causes serosal injury and ischemia. It is usually treated with aggressive fluid support, prokinetics, and anti-inflammatories. Terminology
ICD-10 coding reflects both impaired-peristalsis senses and mechanical-obstruction senses of the term as modified by various adjectives. Some authors have argued for trying to reserve the term for the impaired-peristalsis senses, under which prescription certain older terms such as "gallstone ileus" and "meconium ileus", although now technically misnomers, are still accepted as correct owing to their long-established usage. References
External links

MedlinePlus Encyclopedia: Intestinal Obstruction
Patient UK: Intestinal Obstruction and Ileus
PubMed Health: Intestinal obstruction
Ileus at eMedicine
Merck Manual Professional: Ileus