Farming and gardening correlate with an increased risk of HCL development in some studies which does not necessarily imply causation.A 2011 study identified somatic BRAF V600E mutations in all 47 HCL patients studied, and no such mutations in the 193 peripheral B-cell lymphomas/leukemias other than HCL.The U.S. Institute of Medicine (IOM) found a correlation which permits an association between exposure to herbicides and later development of chronic B-cell leukemias and lymphomas in general. The IOM report emphasizes that neither animal nor human studies indicate an association of herbicides with HCL specifically. However, the IOM extrapolated data from chronic lymphocytic leukemia and non-Hodgkin lymphoma to conclude that HCL and other rare B-cell neoplasms may share this risk factor. As a result of the IOM report, the U.S. Department of Veterans Affairs considers HCL an illness presumed to be a service-related disabilityHuman T-lymphotropic virus 2 (HTLV-2) has been isolated in a small number of patients with the variant form of HCL. In the 1980s, HTLV-2 was identified in a patient with a T-cell lymphoproliferative disease; this patient later developed HCL, but HTLV-2 was not found in the hairy cell clones. There is no evidence that HTLV-II causes any sort of hematological malignancy, including HCL. Pathophysiology
Pancytopenia in HCL is caused primarily by marrow failure and splenomegaly. Bone-marrow failure is caused by the accumulation of hairy cells and reticulin fibrosis in the bone marrow, as well as by the detrimental effects of dysregulated cytokine production.
At that time, the Rolaids website carried the following statement regarding product availability: "You may have noticed that ROLAIDS® products are not available at your local retailers. We are changing some of our manufacturing facilities where our products are made, a process that will take time to complete. We apologize for the inconvenience this may be causing you. Your health and comfort are important to us, and we assure you we are working hard to get ROLAIDS® product back on store shelves. "Another recall was issued around December 9, 2010, as a result of foreign objects that contained metal and wood particles. The foreign materials were caused by a third-party manufacturer during the production process. Several people complained when they took the product; they also had vomiting, strange taste, and tooth and gum injury. After this recall, beyond the small "candy aisle" rolls and chewable lines, the Rolaids line of products was drastically reduced and disappeared from most American retailers until Chattem returned the product to the market in the fall of 2013. Advertising
Rolaids best-known commercial from the 1970s featured the famous tag line:

"How do you spell relief?" "R-O-L-A-I-D-S"In connection with the famous slogan, Rolaids sponsored the Major League Baseball award for top relief pitchers called the Rolaids Relief Man of the Year Award. The award was given yearly from 1976 through 2012. Rolaids softchews
Pfizer released a new version of Rolaids on April 6, 2006, branded Extra Strength Rolaids Plus Gas Relief Softchews.