Symptoms are burning sensation in soles, sometime ankles and legs in many patients. Tingling sensation and pin prick sensations are also common. Sweating of legs and soles is seen. In some case hypertrophy of one of the legs is seen mainly in tropical region where external temperature is also higher. Eponym
Termed Grierson-Gopalan syndrome after Coluther Gopalan and J. Grierson. See also
Erythromelalgia
Small fiber peripheral neuropathy
Tarsal tunnel syndrome
Chemotherapy-induced acral erythema

References


== External links ==
The involvement of the immune system in this putative condition has also been theorized but has never been proven.Purported symptoms of metallosis generally include pain around the site of the implant, pseudotumors (a mass of inflamed cells that resembles a tumor but is actually collected fluids), and a noticeable rash that indicates necrosis. The damaged and inflamed tissue can also contribute to loosening the implant or medical device. Metallosis can cause dislocation of non-cemented implants as the healthy tissue that would normally hold the implant in place is weakened or destroyed. Metallosis has been demonstrated to cause osteolysis.Women, those who are small in stature, and the obese are at greater risk for metallosis because their body structure causes more tension on the implant, quickening the abrasion of the metal components and the subsequent build-up of metallic debris. Physical effects and symptoms
Persons suffering from metallosis can experience any of the following symptoms:

Extreme pain (even when not moving);
Swelling and inflammation;
Loosening of the implant;
Joint dislocation;
Bone deterioration;
Aseptic fibrosis, local necrosis;
Hip replacement failure;
Metal toxicity from grinding metal components; and
Necessary subsequent hip replacement revision or surgeries. Complications
As the grinding components cause metal flakes to shed from the system, the implant wears down. Metallosis results in numerous additional side effects:

Confusion;
Feelings of malaise;
Gastrointestinal problems;
Dizziness;
Headaches;
Problems in the nervous system (feelings of burning, tingling, or numbness of the extremities); and
Cobalt poisoning (skin rashes, cardiomyopathy, problems with hearing, sight or cognition, tremors, and hypothyroidism).