Weakening or dissipation can also occur if a storm experiences vertical wind shear which causes the convection and heat engine to move away from the center; this normally ceases the development of a tropical cyclone. In addition, its interaction with the main belt of the Westerlies, by means of merging with a nearby frontal zone, can cause tropical cyclones to evolve into extratropical cyclones. This transition can take 1–3 days.Should a tropical cyclone make landfall or pass over an island, its circulation could start to break down, especially if it encounters mountainous terrain. When a system makes landfall on a large landmass, it is cut off from its supply of warm moist maritime air and starts to draw in dry continental air. This, combined with the increased friction over land areas, leads to the weakening and dissipation of the tropical cyclone. Over a mountainous terrain, a system can quickly weaken; however, over flat areas, it may endure for two to three days before circulation breaks down and dissipates.Over the years, there have been a number of techniques considered to try to artificially modify tropical cyclones. These techniques have included using nuclear weapons, cooling the ocean with icebergs, blowing the storm away from land with giant fans, and seeding selected storms with dry ice or silver iodide. These techniques, however, fail to appreciate the duration, intensity, power or size of tropical cyclones. Methods for assessing intensity
A variety of methods or techniques, including surface, satellite, and aerial, are utilized to assess the intensity of a tropical cyclone.
Diagnosis
MTHFR deficiency is diagnosed by genetic testing. Management
In common forms of MTHFR deficiency, elevated plasma homocysteine levels have sometimes been treated with Vitamin B12 and low doses of folic acid. Although this treatment significantly decreases the serum levels of homocysteine, this treatment is not thought to improve health outcomes.Due to the ineffectiveness of these treatments, it was no longer considered clinically useful to test for MTHFR in most cases of thrombophilia or recurrent pregnancy loss. A more recent evaluation from a case series recommends testing for MTHFR in case of long lasting impaired fertility and repeat miscarriages. Treatment with high doses of folic acid (5 mg/day) are deemed unsuitable for MTHFR isoform carriers, who could alternatively be treated with the metabolically active form, 5-methyltetrahydrofolate. 5-MTHF was shown to induce significantly higher plasma folate concentrations compared to folic acid in homozygous MTHFR mutation carriers in this case series.A different study corroborates these results and suggests a physiological dose (800 μg) of 5-methyltetrahydrofolate can bypass MTHFR C677T and A1298C isoforms in couples with fertility problems. This treatment with 5-MTHF also avoids un-metabolized folic acid syndrome, which can occur with folic acid intakes of 5 mg per day. Prognosis
Whether MTHFR deficiency has any effect at all on all-cause mortality is unclear. One Dutch study showed that the MTHFR mutation was more prevalent in younger individuals (36% relative to 30%), and found that elderly men with MTHFR had an elevated mortality rate, attributable to cancer. Among women, however, no difference in life expectancy was seen.