It was first described by the Japanese physician Hakaru Hashimoto in 1912. In 1957, it was recognized as an autoimmune disorder. Signs and symptoms
Many symptoms are attributed to the development of Hashimotos thyroiditis. The most common symptoms include: fatigue, weight gain, pale or puffy face, feeling cold, joint and muscle pain, constipation, dry and thinning hair, heavy menstrual flow or irregular periods, depression, panic disorder, a slowed heart rate, and problems getting pregnant and miscarriages.Hashimotos disease is about seven times more common in women than in men. It can occur in teens and young women, but more commonly appears in middle age, particularly for men. People who develop Hashimotos disease often have family members who have thyroid or other autoimmune diseases, and sometimes have other autoimmune diseases themselves.The thyroid gland may become firm, large, and lobulated in Hashimotos thyroiditis, but changes in the thyroid can also be nonpalpable. Enlargement of the thyroid is due to lymphocytic infiltration and fibrosis, rather than tissue hypertrophy. While their role in the initial destruction of the follicles is unclear, antibodies against thyroid peroxidase   or thyroglobulin are relevant, as they serve as markers for detecting the disease and its severity. They are thought to be the secondary products of the T cell-mediated destruction of the gland.It is also characterized by invasion of the thyroid tissue by leukocytes, mainly T-lymphocytes. A rare but serious complication is thyroid lymphoma, generally the B-cell type, non-Hodgkin lymphoma.
Nevus lipomatosus (cutaneous) superficialis (NLS or NLCS, also known as "Nevus lipomatosis of Hoffman and Zurhelle") is characterized by soft, yellowish papules or cerebriform plaques, usually of the buttock or thigh, less often of the ear or scalp, with a wrinkled rather than warty surface. : 625  It is usually congenital
in origin or appears within the first three decades.A pedunculated lipofibroma is a solitary variant of nevus lipomatosus superficialis. It usually appears in adult life, and usually on the axilla, knee, ear, arm, scalp and the lower trunk. In both multiple and solitary variants, the histopathology shows variable amounts of mature lipocytes within the dermis. Occasionally, there is an excessive fibrocollagenous tissue proliferation. The main differential diagnoses are acrochordon, seborrheic keratosis, intradermal melanocytic nevi, neurofibromas, verrucae and fibroepithelioma of Pinkus. See also
Skin lesion
List of cutaneous conditions


== References ==