Nodules are inflamed, painful, deep bumps under the skin.Comedones that are 1 mm or larger are called macrocomedones. They are closed comedones and are more frequent on the face than neck.Solar comedones (sometimes called senile comedones) are related to many years of exposure to the sun, usually on the cheeks, not to acne-related pathophysiology. Management
Using nonoily cleansers and mild soap may not cause as much irritation to the skin as regular soap. Blackheads can be removed across an area with commercially available pore-cleansing strips (which can still damage the skin by leaving the pores wide open and ripping excess skin) or the more aggressive cyanoacrylate method used by dermatologists.Squeezing blackheads and whiteheads can remove them, but  can also damage the skin. Doing so increases the risk of causing or transmitting infection and scarring, as well as potentially pushing any infection deeper into the skin. Comedo extractors are used with careful hygiene in beauty salons and by dermatologists, usually after using steam or warm water.Complementary medicine options for acne in general have not been shown to be effective in trials. These include aloe vera, pyridoxine (vitamin B6), fruit-derived acids, kampo (Japanese herbal medicine), ayurvedic herbal treatments, and acupuncture.Some acne treatments target infection specifically, but some treatments are aimed at the formation of comedones, as well. Others remove the dead layers of the skin and may help clear blocked pores.Dermatologists can often extract open comedones with minimal skin trauma, but closed comedones are more difficult.
Syringomas are benign eccrine sweat duct tumors, typically found clustered on eyelids, although they may also be found in the armpits, abdomen, chest, neck, scalp, or groin area, including genitals, in a symmetric pattern. : 663   They are skin-colored or yellowish firm, rounded bumps, 1–3 mm in diameter, and may be confused with xanthoma, milia, hidrocystoma, trichoepithelioma, and xanthelasma. They are more common in women and are most commonly found in middle-aged Asian women. While they can present at any time in life, they typically present during adolescence. They are usually not associated with any other symptoms, although can sometimes cause itchiness or irritation. Types
The eruptive form typically presents on the anterior chest, abdomen, neck, and arms. It presents in successive crops with periods of relief in between times of active rash. The milia-like  type of syringoma is typically smaller lesions that have a milky white center that can look like milia. The plaque type is more commonly associated with itchiness and chronic scratching that leads to epidermal thickening similar to lichen planus. The familial form, in some cases of syringoma, exhibits a familial pattern in an autosomal-dominant pattern of inheritance. Chromosome 16q22 has been shown to be involved in the genetic links of syringoma. Presentation
Associated syndromes
Syringomas can be found in association with other symptoms as part of a syndrome.