Left ventricular thrombus is a blood clot (thrombus) in the left ventricle of the heart. LVT is a common complication of acute myocardial infarction (AMI). Typically the clot is a mural thrombus, meaning it is on the wall of the ventricle. The primary risk of LVT is the occurrence of cardiac embolism, in which the thrombus detaches from the ventricular wall and travels through the circulation and blocks blood vessels. Blockage can be especially damaging in the heart or brain (stroke). Pathophysiology
LVT occurs most often during the first 2 weeks following AMI. AMI patients most at risk display the 3 characteristics of Virchows triad:

Stagnation of blood
The risk of LVT formation increases as infarction size increases. A larger infarction means a larger area of tissue injury, which may be akinetic or dyskinetic, resulting in stagnation of ventricular blood. Endothelial injury
Monocytes and macrophages play important roles in healing after myocardial infarction. With the absence of monocytes and macrophages, chances of LVT formation are very high. Failure to clear cellular debris from the infarct compromises the endothelial lining of the left ventricle and exposes the damaged tissue to the blood. The response is to build a thrombus composed of fibrin, red blood cells and platelets. Hypercoagulable state
For several days after AMI, the levels of tissue factor and D-dimer, which are involved in coagulation, are high, which increases the risk of LVT formation. LVT may be good for the heart when tissues are severely damaged because it acts to thicken the wall, thus protecting it against rupture.
Pemphigoid is a group of rare autoimmune blistering diseases of the skin, and mucous membranes. As its name indicates, pemphigoid is similar in general appearance to pemphigus, but, unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells.Pemphigoid is more common than pemphigus, and is slightly more common in women than in men. It is also more common in people aged over 70 years than it is in younger people. Classification
IgG
The forms of pemphigoid are considered to be connective tissue autoimmune skin diseases. There are several types:

Gestational pemphigoid (PG) (formerly called Herpes gestationis)
Bullous pemphigoid (BP) Rarely affects the mouth
Mucous membrane pemphigoid (MMP) or (cicatricial pemphigoid), (No skin involvement)Bullous and mucous membrane pemphigoid usually affect persons who are over age 60. Gestational pemphigoid occurs during pregnancy, typically in the second or third trimester, or immediately following pregnancy. IgA
Pemphigoid is usually considered to be mediated by IgG, but IgA-mediated forms have also been described.IgA-mediated immunobullous diseases can often be difficult to treat even with usually effective medications such as rituximab. Bullous pemphigoid
Bullous pemphigoid is a rare and chronic autoimmune disorder characterised by large sub-epidermal blisters called bullae, that predominantly involves the skin and less commonly the mucous membranes. It is the most common type of the pemphigoid group, representing 80% of sub-epidermal immunobullous cases. It is more commonly known as cutaneous pemphigoid. Presentation
Primary lesions of small and large blisters, known as vesicles and bullae, are found on the skin and sometimes on the mucous membranes.