The most common treatment is dopamine replacement therapy, which consists in the administration of levodopa (L-Dopa) or dopamine agonists (such as pramipexole or ropinirole) to patients. Dopamine replacement therapy is well known to improve motor symptoms but its effects in cognitive and behavioral symptoms are more complex. Dopamine has been related to the normal learning of stimuli with behavioral and motivational significance, attention, and most importantly the reward system. In accordance with the role of dopamine in reward processing, addictive drugs stimulate dopamine release. Although the exact mechanism has yet to be elucidated, the role of dopamine in the reward system and addiction has been proposed as the origin of DDS. Models of addiction have been used to explain how dopamine replacement therapy produces DDS. One of these models of addiction proposes that over the usage course of a drug there is a habituation to the rewarding effects that it produces at the initial stages. This habituation is thought to be dopamine mediated. With long-term administration of L-dopa the reward system gets used to it and needs higher quantities. As the user increases drug intake there is a loss of dopaminergic receptors in the striatum which acts in addition to an impairment in goal-direction mental functions to produce an enhancement of sensitization to dopamine therapy. The behavioral and mood symptoms of the syndrome are produced by the dopamine overdose. Diagnosis
Diagnosis of the syndrome is clinical since there are no laboratory tests to confirm it.
Minimally invasive procedures as; bilateral greater occipital nerve block  or sphenopalatine ganglion block. Persistent and severe PDPH may require an epidural blood patch. A small amount of the persons blood is injected into the epidural space near the site of the original puncture; the resulting blood clot then "patches" the meningeal leak. EBP is effective, and further intervention is rarely necessary. 25-35% of patients suffer from transient back pain after EBP. More rare complications of EBP include misplacement of blood leading to spinal subdural hematoma or intrathecal injection and arachnoiditis, infection with subdural abscess, facial nerve paralysis, spastic paraparesis and cauda equina syndrome. Epidemiology
Estimates for the overall incidence of PDPH vary between 0.1% and 36%. It is more common in younger patients (especially in the 18–30 age group), females (especially those who are pregnant), and those with a low body mass index (BMI). The low prevalence in elderly patients may be due to a less stretchable dura mater. It is also more common with the use of larger diameter needles.