Adverse effects
The most common side effect is bone marrow suppression. The most common non-hematological adverse effects associated with temozolomide are nausea and vomiting, which are either self-limiting or readily controlled with standard antiemetic therapy. These latter effects are usually mild to moderate (grade 1 to 2). The incidence of severe nausea and vomiting is around 4% each. Patients who have pre-existing or a history of severe vomiting may require antiemetic therapy before initiating temozolomide treatment. Temozolomide should be administered in the fasting state, at least one hour before a meal. Antiemetic therapy may be administered before, or following, administration of temozolomide. Temozolomide is genotoxic, teratogenic and fetotoxic and should not be used during pregnancy. Lactating women should discontinue nursing while receiving the drug because of the risk of secretion into breast milk. One study indicated that women that have taken temozolomide without concomitant fertility preservation measures achieve pregnancy to a lesser rate later in life, but the study was too small to show statistical significance in the hypothesis that temozolomide would confer a risk of female infertility. In male patients, temozolomide can have genotoxic effects. Men are advised not to father a child during or up to six months after treatment and to seek advice on cryoconservation of sperm prior to treatment, because of the possibility of irreversible infertility due to temozolomide therapy. Very rarely temozolomide can cause acute respiratory failure or liver damage.
Out may refer to:

Arts, entertainment, and media
Films
Out (1957 film), a documentary short about the Hungarian Revolution of 1956
Out (1982 film), an American film directed by Eli Hollander
Out (2002 film), a Japanese film based on the novel by Natsuo Kirino and directed by Hideyuki Hirayama
Out (2013 film), a Canadian short comedy film directed by Jeremy LaLonde
Out (2017 film), a Slovak film directed by György Kristóf
Out (2020 film), an American animated film produced by Pixar

Music
Out (jazz) or outside, an approach to jazz improvisation
OUT, a band produced by Adam Walton
OUT, a 1994 album by Nav Katze
Out (In Essence), a 1991 album by Fluke

Television
Out (miniseries), a 1978 British television crime drama starring Tom Bell
"Out" (Dark Angel), a television episode

Other uses in arts, entertainment, and media
Out (magazine), an LGBT fashion, entertainment, and lifestyle magazine
Out (novel), a 1997 novel by Natsuo Kirino
OUTeverywhere, a community website for LGBT people around the world

Sports and recreation
Out (baseball), a play which retires the batter or a base runner
Out (cricket), the loss of a wicket by a batsman; also known as "dismissal"
Out (poker), an unseen card which is expected to win a hand, if drawn
Out (route), a pattern run by a receiver in American football

Sexuality
Coming out, publicly revealing ones own LGBT status
Outing, publicly revealing someone elses LGBT status

Mathematics
Out(Fn), the outer automorphism group of a free group on n generators
Outer automorphism group, a quotient Out(G) of the automorphism group

Transport
Outwood railway station, West Yorkshire, National Rail station code

Other uses
Out, a procedure word in voice radio communication

See also
Outing (disambiguation)
Outside (disambiguation)
All pages with titles containing Out
All pages with titles beginning with Out