While serious effects are rare and have most often resulted from misuse, adverse reactions have occurred when used properly. The FDA, therefore, requires a so-called black box warning on lindane products, which explains the risks of lindane products and their proper use.The black box warning emphasizes that lindane should not be used on premature infants and individuals with known uncontrolled seizure disorders, and should be used with caution in infants, children, the elderly, and individuals with other skin conditions (e.g., dermatitis, psoriasis) and people who weigh less than 110 lb (50 kg), as they may be at risk of serious neurotoxicity. Environmental contamination
Lindane is a persistent organic pollutant: it is relatively long-lived in the environment, it is transported long distances by natural processes like global distillation, and it can bioaccumulate in food chains, though it is rapidly eliminated when exposure is discontinued.The production and agricultural use of lindane are the primary causes of environmental contamination, and levels of lindane in the environment have been decreasing in the U.S., consistent with decreasing agricultural usage patterns. The production of lindane generates large amounts of waste hexachlorocyclohexane isomers, and "every ton of lindane manufactured produces about nine tons of toxic waste." Modern manufacturing standards for lindane involve the treatment and conversion of waste isomers to less toxic molecules, a process known as "cracking".When lindane is used in agriculture, an estimated 12–30% of it volatilizes into the atmosphere, where it is subject to long-range transport and can be deposited by rainfall.
However, it has a high mortality, and there have been reports of a vegetative state and seizures resuming, this time in the healthy hemisphere.Surgery should be done as early as possible to minimize damage caused by seizures. However, a trial with drugs can be attempted for a few months before surgery, and there is a slim chance of it succeeding. The earlier surgery be done, the more the remaining side will do the missing sides job.Benzodiazepines might control the seizures. References


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