General adaptation syndrome
The process whereby the human body responds to extended stress is known as general adaptation syndrome (GAS). After the initial fight-or-flight response, the body becomes more resistant to stress in an attempt to dampen the sympathetic nervous response and return to homeostasis. During this period of resistance, physical and mental symptoms of CSR may be drastically reduced as the body attempts to cope with the stress. Long combat involvement, however, may keep the body from homeostasis and thereby deplete its resources and render it unable to normally function, sending it into the third stage of GAS: exhaustion. Sympathetic nervous activation remains in the exhaustion phase and reactions to stress are markedly sensitized as fight-or-flight symptoms return. If the body remains in a state of stress, then such more severe symptoms of CSR as cardiovascular and digestive involvement may present themselves. Extended exhaustion can permanently damage the body.
Joe: Americas Elite
The Plague, a duo of demonic assassins in the movie Hobo with a Shotgun

Films and television
Plague (1979 film), a science-fiction film
The Plague (1992 film), a drama film
The Plague (2006 film), a horror film
Plague (2014 film), an Australian horror film
La peste (TV series), Spanish historical drama series broadcast in the UK as The Plague

Games
Corrupted Blood incident, a virtual plague that occurred in the video game World of Warcraft
Plague Inc., a strategy game for smartphones and tablets by Ndemic Creations
Plague!, a card game about the Black Plague in England
Plague of Shadows (Plague Knight), a character and DLC gamemode for Shovel Knight
The Plague, a playable killer character of Babylonian origin from the asymmetrical-survival horror Dead by Daylight

Literature
Plague, a 2000 young adult novel by Malcolm Rose
Plague, a 1977 thriller novel by Graham Masterton
Plague 99, a novel by Jean Ure
The Plague (novel), a novel by Albert Camus
"The Plague" (Dragon Prince), an epidemic which affects both humans and dragons in Melanie Rawns novel
The Plague (magazine), New York Universitys comedy magazine

Music
Artists
The Plague (American band), a hardcore punk band from Cleveland
The Plague (English band), a punk rock band
The Plague (New Zealand band), a theatrical punk/art rock band

Albums
Plague (Klinik album)
Plagues (album), by The Devil Wears Prada
The Plague, by Demon
The Plague (Brotha Lynch Hung album)

EPs
The Plague (Nuclear Assault EP)
The Plague (I Hate Sally EP)

Songs
"Plague", by Crystal Castles from the 2012 album III
"The Plague", by Demon from the 1983 album by the same name
"The Plague," an unreleased song by The Mountain Goats that appears on the 2020 live album The Jordan Lake Sessions

Musicals
Plague!