Myiasis is also not restricted to sheep; screwworm flies (Cochliomyia hominivorax in particular) regularly cause upwards of US$100 million in annual damages to domestic cows and goats, though the impact has been heavily mitigated in recent years by the sterile insect technique. History
Frederick William Hope coined the term myiasis in 1840 to refer to diseases resulting from dipterous larvae as opposed to those caused by other insect larvae (the term for this was scholechiasis). Hope described several cases of myiasis from Jamaica caused by unknown larvae, one of which resulted in death.Even though the term myiasis was first used in 1840, such conditions have been known since ancient times. Ambroise Paré, the chief surgeon to King Charles IX and King Henry III, observed that maggots often infested open wounds. Maggot therapy
Throughout recorded history, maggots have been used therapeutically to clean out necrotic wounds, an application known as maggot therapy.Fly larvae that feed on dead tissue can clean wounds and may reduce bacterial activity and the chance of a secondary infection. They dissolve dead tissue by secreting digestive enzymes onto the wound as well as actively eating the dead tissue with mouth hooks, two hard, probing appendages protruding on either side of the "mouth".
Synthesis
Avanafil can be synthesized from a benzylamine derivative and a pyrimidine derivative:

References
External links
"Avanafil". Drug Information Portal. U.S. National Library of Medicine.