Like most of the movement disorders, alien hand syndrome also presents asymmetrically in those diagnosed with CBD. Apraxia
Ideomotor apraxia (IMA), although clearly present in CBD, often manifests atypically due to the additional presence of bradykinesia and rigidity in those individuals exhibiting the disorders. The IMA symptom in CBD is characterized by the inability to repeat or mimic particular movements (whether significant or random) both with or without the implementation of objects. This form of IMA is present in the hands and arms, while IMA in the lower extremities may cause problems with walking. Those with CBD that exhibit IMA may appear to have trouble initiating walking, as the foot may appear to be fixed to floor. This can cause stumbling and difficulties in maintaining balance. IMA is associated with deterioration in the premotor cortex, parietal association areas, connecting white matter tracts, thalamus, and basal ganglia. Some individuals with CBD exhibit limb-kinetic apraxia, which involves dysfunction of more fine motor movements often performed by the hands and fingers. Aphasia
Aphasia in CBD is revealed through the inability to speak or a difficulty in initiating spoken dialogue and falls under the non-fluent (as opposed to fluent or flowing) subtype of the disorder. This may be related to speech impairment such as dysarthria, and thus is not a true aphasia, as aphasia is related to a change in language function, such as difficulty retrieving words or putting words together to form meaningful sentences. The speech and/or language impairments in CBD result in disconnected speech patterns and the omission of words.
One or more of:
limb rigidity or akinesia
limb dystonia
limb myoclonus, plus one of:
orobuccal or limb apraxia
cortical sensory deficit
alien limb phenomena (more than simple levitation)More likely (probable sporadic CBS) if:
Asymmetric presentation
Onset after age 50
No family history (2 or more relatives)
No genetic mutation affecting T (e.g. MAPT)
plus two of:limb rigidity or akinesia
limb dystonia
limb myoclonusplus two of:orobuccal or limb apraxia,
cortical sensory deficit
alien limb phenomena (more than simple levitation)

Frontal behavioural-spatial syndrome subtype
Two of:
executive dysfunction
behavioural or personality changes
visuospatial deficits

NAV of primary progressive aphasia subtype
Effortful, agrammatic speech plus at least one of:
impaired grammar/sentence comprehension with relatively preserved single word comprehension or
groping, distorted speech production (apraxia of speech)

Progressive supranuclear palsy syndrome subtype
Three of:
axial or symmetric limb rigidity or akinesia
postural instability or falls
urinary incontinence
behavioural changes
supranuclear vertical gaze palsy or decreased vertical saccade velocity

Exclusion criteria
These apply to all types of CBD. Evidence of Lewy body disease
multiple system atrophy
Alzheimers disease
ALS
semantic or logopenic variant primary progressive aphasia
structural lesion suggestive of focal cause
granulin mutation or reduced plasma progranulin levels
TDP-43 or fused in sarcoma (FUS) mutationsThe diagnostic criteria for clinical use may result in a misdiagnosis of other tau-based diseases.The probable criteria are proposed for clinical research. Clinical vs. postmortem
One of the most significant problems associated with CBD is the inability to perform a definitive diagnosis while an individual exhibiting the symptoms associated with CBD is still alive. A clinical diagnosis of CBD is performed based upon the specified diagnostic criteria, which focus mainly on the symptoms correlated with the disease. However, this often results in complications as these symptoms often overlap with numerous other neurodegenerative diseases.