A myeloid sarcoma (chloroma, granulocytic sarcoma,: 744  extramedullary myeloid tumor) is a solid tumor composed of immature white blood cells called myeloblasts. A chloroma is an extramedullary manifestation of acute myeloid leukemia; in other words, it is a solid collection of leukemic cells occurring outside of the bone marrow. Types
In acute leukemia
Chloromas are rare; exact estimates of their prevalence are lacking, but they are uncommonly seen even by physicians specializing in the treatment of leukemia. Chloromas may be somewhat more common in patients with the following disease features:
French–American–British (FAB) classification class M2
WHO Classification (2016 revision) is a separate entity under the "Acute myeloid leukemia (AML) and related neoplasms"
those with specific cytogenetic abnormalities (e.g. t(8;21) or inv(16))
those whose myeloblasts express T-cell surface markers, CD13, or CD14
those with high peripheral white blood cell countsHowever, even in patients with the above risk factors, chloroma remains an uncommon complication of acute myeloid leukemia. Rarely, a chloroma can develop as the sole manifestation of relapse after apparently successful treatment of acute myeloid leukemia. In keeping with the general behavior of chloromas, such an event must be regarded as an early herald of a systemic relapse, rather than as a localized process. In one review of 24 patients who developed isolated chloromas after treatment for acute myeloid leukemia, the mean interval until bone marrow relapse was 7 months (range, 1 to 19 months). In myeloproliferative or myelodysplastic syndromes
Chloromas may occur in patients with a diagnosis of myelodysplastic syndrome (MDS) or myeloproliferative syndromes (MPS) (e.g.
Myoglobinuria is the presence of myoglobin in the urine, which usually results from rhabdomyolysis or muscle injury. Myoglobin is present in muscle cells as a reserve of oxygen. Signs and symptoms
Signs and symptoms of myoglobinuria are usually nonspecific and needs some clinical prudence. Therefore, among the possible signs and symptoms to look for would be:
Swollen and painful muscles
Fever, nausea
Delirium (elderly individuals)
Myalgia
Dark urine
Calcium ion loss

Causes
Trauma, vascular problems, malignant hyperthermia, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys. Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of kidney problems, it can occlude the kidneys filtration system leading to acute tubular necrosis and acute kidney injury. Other causes of myoglobinuria include:

McArdles disease
Phosphofructokinase deficiency
Carnitine palmitoyltransferase II deficiency
Malignant hyperthermia
Polymyositis
Lactate dehydrogenase deficiency
Adenosine monophosphate deaminase deficiency type 1
Thermal or electrical burn

Pathophysiology
Myoglobinuria pathophysiology consists of a series of metabolic actions in which damage to muscle cells affect calcium mechanisms, thereby increasing free ionized calcium in the cytoplasm of the myocytes (concurrently decreasing free ionized calcium in the bloodstream). This, in turn, affects several intracellular enzymes that are calcium-dependent, thereby compromising the cell membrane, which in turn causes the release of myoglobin. Diagnosis
After centrifuging, the urine of myoglobinuria is red, where the urine of hemoglobinuria after centrifuge is pink to clear. Treatment
Hospitalization and IV hydration should be the first step in any patient suspected of having myoglobinuria or rhabdomyolysis.