Physiological effects
Dinoprostone has important effects in labor by inducing softening of the cervix and causing uterine contraction, and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts.Natural prostaglandins, including PGE1 and PGE2, are important in the structure and function of the ductus arteriosus in fetuses and newborns. They allow the ductus arteriosus to remain open, providing the necessary connection between the pulmonary artery and descending aorta that allows the blood to bypass the fetuss underdeveloped lungs and be transported to the placenta for oxygenation. The ductus arteriosus normally begins to close upon birth due to an increase of PGE2 metabolism, but in newborns with congenital heart disease, prostaglandins can be used to keep the ductus arteriosus open longer than normal to sustain healthy oxygen saturation levels in the blood. Although PGE1 is more commonly used in this setting, there has been a report of oral PGE2 being used to treat ductus-dependent congenital heart diseases in newborns to delay surgical treatment until the pulmonary arteries grew. In addition, PGE2 was used in another report to dilate the ductus arteriosus in newborns with various cardiovascular defects to allow for better perfusion of the lungs and kidneys.
A myoma is a type of tumor that involves muscle cells. There are two main types of myoma: 

Leiomyomas which occur in smooth muscle. They most commonly occur as uterine fibroids, but may also form in other locations. Rhabdomyomas which occur in striated muscle. They are rare tumors, occur in childhood and often become malignant.Whether or not angiomyomas are a type of leiomyoma or a separate entity is disputed as of 2014.Myomas are benign tumors of the uterus that can affect the fertility of a woman depending mainly on three factors:

Size (cut off value 4-5 cm)
Number
Location (they can be intramural, subserous or submucous). Submucous ones are worst from a fertility point of view, while subserous are less dangerous.Some of the most common symptoms are: abundant menstrual bleeding, longer menstrual periods, pelvic pressure, constipation, a need to urinate continuously. References


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