There is currently no treatment for MM, however promising improvements have been made and the study is still ongoing.In March 2020, it was approved for medical use in the United States.The U.S. Food and Drug Administration (FDA) approved isatuximab-irfc in March 2020, based on evidence from a clinical trial (NCT02990338) of 307 subjects with previously treated multiple myeloma. The trial was conducted at 102 sites in Europe, North America, Asia, Australia and New Zealand.The trial evaluated the efficacy and side effects of isatuximab-irfc in subjects with previously treated multiple myeloma. Subjects were randomly assigned to receive either isatuximab-irfc (in combination with pomalidomide and low-dose dexamethasone) or active comparator (pomalidomide and low-dose dexamethasone). Treatment was administered in both groups in 28-day cycles until disease progression or unacceptable toxicity. Both subjects and health care providers knew which treatment was given. The trial measured the time patients lived without the cancer growing (progression-free survival or PFS).It was approved for medical use in the European Union in May 2020. Structure and reactivity
The structure of isatuximab consists of two identical immunoglobulin kappa light chains and also two equal immunoglobulin gamma heavy chains. Chemically, isatuximab is similar to the structure and reactivity of daratumumab, hence both drugs show the same CD38 targeting. However, isatuximab shows a more potent inhibition of its ectozyme function. The latter gives potential for some non-cross reactivity. Isatuximab shows action of an allosteric antagonist with the inhibition of the CD38 enzymatic activity. Additionally, isatuximab shows potential where it can induce apoptosis without cross linking.
Treatment
The most common treatment in animals is weekly use of some form of topical pesticide appropriate for the affected animal, often an antiflea product. Fipronil works well, especially in cats. Cats can also be treated with a lime sulfur insecticide dip or a shampoo with non-pyrethrin insecticide for two weeks beyond the conclusion of symptoms.In unresponsive cases, ivermectin is used. Selamectin is also recommended for treatment. None of these products are approved for treatment of cheyletiellosis. Other pets in the same household should also be treated, and the house or kennel must be treated with an environmental flea spray. Species
Cheyletiella blakei Smiley, 1970 — infests cats (Felis catus), USA (Washington DC)
Cheyletiella parasitivorax  — infests rabbits (Oryctolagus cuniculus), France
Cheyletiella romerolagi (Fain, 1972) — infests Romerolagus diazi, USA (New York)
Cheyletiella strandtmanni  Smiley, 1970 — infests hares (Lepus spp. ), Taiwan
Cheyletiella yasguri Smiley, 1965 — infests dogsC. yasguri and C. blakei can transiently affect humans. See also
List of mites associated with cutaneous reactions
Mange


== References ==