Parkinsons disease and dementia with Lewy bodies)
Lactation
Children before the onset of pubertyNeither is it recommended to use amisulpride in patients with hypersensitivities to amisulpride or the excipients found in its dosage form. Adverse effects
Very Common (≥10% incidence)Extrapyramidal side effects (EPS; including dystonia, tremor, akathisia, parkinsonism).Common (≥1%, <10% incidence)
Hyperprolactinaemia (which can lead to galactorrhoea, breast enlargement and tenderness, sexual dysfunction, etc.) Weight gain (produces less weight gain than chlorpromazine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zotepine and more (although not statistically significantly) weight gain than haloperidol, lurasidone, ziprasidone and approximately as much weight gain as aripiprazole and asenapine)
Anticholinergic side effects (although it does not bind to the muscarinic acetylcholine receptors and hence these side effects are usually quite mild) such as- constipation
- dry mouth
- disorder of accommodation
- Blurred vision
Rare (<1% incidence)
Blood dyscrasias such as leucopenia, neutropenia and agranulocytosis
QT interval prolongation (in a recent meta-analysis of the safety and efficacy of 15 antipsychotic drugs amisulpride was found to have the 2nd highest effect size for causing QT interval prolongation)Hyperprolactinaemia results from antagonism of the D2 receptors located on the lactotrophic cells found in the anterior pituitary gland. Amisulpride has a high propensity for elevating plasma prolactin levels as a result of its poor blood-brain barrier penetrability and hence the resulting greater ratio of peripheral D2 occupancy to central D2 occupancy.
British desires to secure control of West African gold deposits played a role in the Anglo-Ashanti wars of the late 19th century, which saw the Ashanti Empire annexed by Britain.Gold played a role in western culture, as a cause for desire and of corruption, as told in childrens fables such as Rumpelstiltskin—where Rumpelstiltskin turns hay into gold for the peasants daughter in return for her child when she becomes a princess—and the stealing of the hen that lays golden eggs in Jack and the Beanstalk. The top prize at the Olympic Games and many other sports competitions is the gold medal. 75% of the presently accounted for gold has been extracted since 1910, two-thirds since 1950. One main goal of the alchemists was to produce gold from other substances, such as lead — presumably by the interaction with a mythical substance called the philosophers stone. Trying to produce gold led the alchemists to systematically find out what can be done with substances, and this laid the foundation for todays chemistry, which can produce gold (albeit uneconomically) by using nuclear transmutation. Their symbol for gold was the circle with a point at its center (☉), which was also the astrological symbol and the ancient Chinese character for the Sun. The Dome of the Rock is covered with an ultra-thin golden glassier. The Sikh Golden temple, the Harmandir Sahib, is a building covered with gold. Similarly the Wat Phra Kaew emerald Buddhist temple (wat) in Thailand has ornamental gold-leafed statues and roofs.