One of the most common mutations implicated in the development of familial hypertriglyceridemia is a heterozygous inactivating mutation of the LPL gene. Inactivation of this gene leads to an individuals inability to hydrolyze the triglycerides within the VLDL core. This inactivation of function leads to a considerable accumulation of triglycerides and VLDL in the bloodstream, which then contributes to several avenues of pathology. Individuals with insulin resistance can have even further elevated levels of hypertriglyceridemia due to the fact that insulin is a potent activator of LPL. Therefore, an individual who is resistant to the bioactivity of insulin will have decreased LPL activity and will therefore lead to further hypertriglyceridemia, helping push serum triglycerides to pathologic levels. Beyond the classic understanding of single-gene mutation leading to disease, hypertriglyceridemia is also linked to several different genetic loci permitting additional aberrant changes to other lipid levels in the body. Epidemiology
Familial hypertriglyceridemia can follow an autosomal dominant monogenic inheritance pattern. The frequency of heterozygous carriers of certain pathologic mutations in the LPL gene can range from 0.06% to 20%. It is important to note that dissimilar mutations can confer varying degrees of underlying pathology. However, most cases of familial hypertriglyceridemia follow a polygenic inheritance pattern involving mutations in multiple genetic foci. Pathophysiology
Inactivity of lipoprotein lipase (LPL) plays the predominant role in the development of familial hypertriglyceridemia. LPL plays a role in the metabolism of triglycerides within VLDL molecules. Inactivation mutations in LPL will create an environment with an increased concentration of VLDL molecules and therefore, triglycerides.
Siti or SITI may refer to:

People
Siti (given name), a common Malay female given name
Siti Kassim (born 1961), Comorian politician
Siti Mwinyi (born 1932), Tanzanian first lady
Beáta Siti (born 1973), Hungarian handball player and coach
Eszter Siti (born 1977), Hungarian handball player
Walid Siti (born 1952), Kurdish artist
Siti Badriah (born 1991), musical artist Dancedhut at the Productions Nagaswara

Places
Siti Hydroelectric Power Station (disambiguation)

Other
Siti, character in Opera Jawa
Saratoga International Theater Institute, theater  company in New York, United States
SITI: An Iconic Exhibition of Dato Siti Nurhaliza
Siti (film), 2014 Indonesian film
Siti Networks
Siti language
Stevens Institute of Technology International, former private university in Dominican Republic

See also
All pages with titles containing Siti
All pages with titles beginning with Siti