In 2009 and 2010, hydrocodone was the second most frequently encountered opioid pharmaceutical in drug evidence submitted to U.S. federal, state, and local forensic laboratories as reported by DEAs National Forensic Laboratory Information System (NFLIS) and System to Retrieve Information from Drug Evidence (STRIDE). Pregnancy and breastfeeding
Pregnancy category C: Risk in pregnancy cannot be ruled out. Animal controlled studies have not been conducted with this medication.Low concentrations of paracetamol is excreted through breast milk, however, hydrocodones excretion is unknown. Kidney and liver impairment
Use with caution due to possible risk of toxicity. Side effects
Most common
Lightheadedness
Dizziness
Euphoria
Sedation
Nausea and vomiting
Headaches

Less common
Central nervous system: drowsiness, confusion, lethargy, anxiety, fear, unease, dependence, mood changes, impairment of mental and physical performance
Gastrointestinal system: constipation
Genitourinary system: inability to urinate, bladder spasms
Respiratory depression: decreased rate and effort of breathing
Hearing impairment, permanent hearing loss
Dermatological: rash, itching

Black box warning
"Paracetamol has been associated with cases of acute liver failure, at times resulting in liver transplant or death. Most of the cases of liver injury are associated with the use of paracetamol at doses that exceed 4000 milligrams per day, and often involve more than one paracetamol-containing product." Allergy warning
"Do not take hydrocodone bitartrate and paracetamol tablets if you are allergic to any of its ingredients. If you develop signs of allergy such as a rash or difficulty breathing stop taking hydrocodone bitartrate and paracetamol tablets and contact your healthcare provider immediately."
The FDA also required manufacturers on all paracetamol containing products to issue a black box warning indicating the potential risk for severe liver injury and a warning highlighting potential for allergic reactions.On 22 August 2014, the Drug Enforcement Administration (DEA) announced that all hydrocodone combination products (HCPs) will be rescheduled from Schedule III to Schedule II of the Controlled Substances Act (CSA), effective on 6 October 2014. In 2010, more than 16,000 deaths were attributed to abuse of opioid drugs. Even though there are legitimate medical uses for HCPs, data suggest that a significant number of individuals misuse them. Popular culture
Vicodin is mentioned in songs such as Juice Wrlds "Already Dead" Eminems "Kill You", Blackbears "Sniffing Vicodin in Paris", Kendrick Lamars "A.D.H.D", Futures "Lay Up", Lupe Fiascos "Mural", Queens of the Stone Ages "Feel Good Hit of the Summer", A Winged Victory for the Sullens "Steep Hills of Vicodin Tears", Death Gripss "Anne Bonny" and The Wombats "Give Me a Try". Vicodin use is a central theme in the 2004–2012 medical TV drama House, in which the lead character Dr. Gregory House is addicted to the drug combination. Brand names
Brand names include Adol, Hycet, Lortab, Lorcet, Norco, and Vicodin among others. See also
Hydrocodone/aspirin
Hydrocodone/ibuprofen
Oxycodone/paracetamol

References
External links
"Acetaminophen mixture with Hydrocodone bitartrate". Drug Information Portal. U.S. National Library of Medicine. Vicodin U.S. Federal Regulations Archived 18 January 2017 at the Wayback Machine