When failure of tissues to fuse together that are forming early in pregnancy, defect can happen and jaw is incomplete. For example, cleft lip and palate when one of the jaws embryological processes failed to fuse together or the agenesis of the condylar process of the mandible, which may be seen in hemifacial microsomia. Clinically, cleft palate  presents as opening in the palate that can affect the front palate only or extending from the front to the back palate. Cleft lip is presented clinically with opening of the upper lip which can be a small slit on the upper lip or large opening connected to the nose. The cleft can be unilateral on the upper lip or bilaterally. Cleft lip can happen together with cleft palate.Palatal clefts are one of the most common congenital abnormalities which occur in 1:2500 live births. Embryologically, palate formation takes place in two stages, with the primary palate formed after 6th week followed by secondary palate formation between sixth and eighth weeks. The palate will fuse with the medial nasal process to form the roof of the mouth in order to complete the developmental process. However, if this process is incomplete that is when developmental defect occur. Initially, it is just a common oro-nasal cavity within the embryo with nothing to separate the nose and mouth cavity. This space is occupied with tongue. The primary palate formed when medial nasal prominences fused together to form the intermaxillary segment to demarcate the oral from the nasal components.
Rarely, they can be associated with Birt–Hogg–Dubé syndrome, acromegaly, or polycystic ovary syndrome.Elevated blood sugar and insulin is linked to an increased incidence of skin tags through an unknown mechanism. Treatment
If removal is desired or warranted, it can be achieved by a dermatologist, general practitioner or similarly trained professional who may use cauterization, cryosurgery, excision, laser, or surgical ligation to remove the acrochorda. Varied home remedies are also available, but most are unproven and some (e.g. tea tree oil) may cause allergic skin reactions. See also
Molluscum contagiosum (a viral disease which is similar in appearance and grows in similar areas)
List of cutaneous neoplasms associated with systemic syndromes
Papilloma
Cutaneous horn

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