This is misleading, as DLD is not caused by brain damage.Although the term DLD has been used for many years, it has been less common than the term specific language impairment (SLI), which has been widely adopted, especially in North America. The definition of SLI overlaps with DLD, but was rejected by the CATALISE panel because it was seen as overly restrictive in implying that the child had relatively pure problems with language in the absence of any other impairments. Children with such selective problems are relatively rare, and there is no evidence that they respond differently to intervention, or have different causal factors, from other children with language problems.In the UK education system, the term speech, language and communication needs (SLCN) is widely used, but this is far broader than DLD, and includes children with speech, language and social communication difficulties arising from a wide range of causes.The question of whether to refer to childrens language problems as a disorder was a topic of debate among the CATALISE consortium, but the conclusion was that disorder conveyed the serious nature and potential consequences of persistent language deficits. It is also parallel with other neurodevelopmental conditions and consistent with diagnostic frameworks such as the DSM-5 and ICD-11. Where there are milder or more transient difficulties, language difficulties may be a more appropriate term. Areas of language difficulty
DLD can affect a range of areas of language and the degree of impairment in different areas of language can vary from child to child.
Pyoderma gangrenosum is a rare, inflammatory skin disease where painful pustules or nodules become ulcers that progressively grow. Pyoderma gangrenosum is not infectious.Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab.The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s. Types
There are two main types of pyoderma gangrenosum:
the typical ulcerative form, which occurs in the legs
an atypical form that is more superficial and occurs in the hands and other parts of the bodyOther variations are:
Peristomal pyoderma gangrenosum comprises 15% of all cases of pyoderma
Bullous pyoderma gangrenosum
Pustular pyoderma gangrenosum
Vegetative pyoderma gangrenosum

Presentation
Associations
The following are conditions commonly associated with pyoderma gangrenosum:
Inflammatory bowel disease:
Ulcerative colitis
Crohns disease
Arthritides:
Rheumatoid arthritis
Seronegative arthritis
Hematological disease:
Myelocytic leukemia
Hairy cell leukemia
Myelofibrosis
Myeloid metaplasia
Monoclonal gammopathy
Autoinflammatory disease:
Pyogenic sterile arthritis, and acne syndrome (PAPA syndrome)

Causes
Though the cause is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. In support of an immune cause, a variety of immune mediators such as interleukin (IL)-8, IL-1β, IL-6, interferon (IFN)-γ, granulocyte colony-stimulating factor, tumor necrosis factor alpha, matrix metalloproteinase (MMP)-9, MMP10, and elafin have all been reported to be elevated in patients with pyoderma gangrenosum.Also in support of an immune cause is the finding that at least half of all pyoderma gangrenosum patients suffer from immune-mediated diseases. For instance, ulcerative colitis, rheumatoid arthritis, and multiple myeloma (MM) have all been associated with pyoderma gangrenosum.