Synthesis
C1-inhibitor is contained in the human blood; it can, therefore, be isolated from donated blood. Risks of infectious disease transmission (viruses, prions, etc.) and relative expense of isolation prevented widespread use. It is also possible to produce it by recombinant technology, but Escherichia coli (the most commonly used organism for this purpose) lacks the eukaryotic ability to glycosylate proteins; as C1-inhibitor is particularly heavily glycosylated, this sialylated recombinant form would have a short circulatory life (the carbohydrates are not relevant to the inhibitor function). Therefore, C1-inhibitor has also been produced in glycosylated form using transgenic rabbits. This form of recombinant C1-inhibitor also has been given orphan drug status for delayed graft function following organ transplantation and for capillary leakage syndrome. References
Further reading
External links
Human SERPING1 genome location and SERPING1 gene details page  in the UCSC Genome Browser. "SERPING1". Drug Information Portal. U.S. National Library of Medicine. The MEROPS online database for peptidases and their inhibitors: I04.024
B02AB03 (WHO)
Overview of all the structural information available in the PDB for UniProt: P05155 (Plasma protease C1 inhibitor) at the PDBe-KB.
There is a 39% average rate of recurrence of anterior shoulder dislocation, with age, sex, hyperlaxity and greater tuberosity fractures being the key risk factors. Knee: Patellar dislocation
Many different knee injuries can happen. Three percent of knee injuries are acute traumatic patellar dislocations. Because dislocations make the knee unstable, 15% of patellas will re-dislocate. Patellar dislocations occur when the knee is in full extension and sustains a trauma from the lateral to medial side. Elbow: Posterior dislocation, 90% of all elbow dislocations
Wrist: Lunate and Perilunate dislocation most common
Finger: Interphalangeal (IP) or metacarpophalangeal (MCP) joint dislocationsIn the United States, men are most likely to sustain a finger dislocation with an incidence rate of 17.8 per 100,000 person-years. Women have an incidence rate of 4.65 per 100,000 person-years. The average age group that sustain a finger dislocation are between 15 and 19 years old. Hip: Posterior and anterior dislocation of hip
Anterior dislocations are less common than posterior dislocations. 10% of all dislocations are anterior and this is broken down into superior and inferior types. Superior dislocations account for 10% of all anterior dislocations, and inferior dislocations account for 90%. 16-40 year old males are more likely to receive dislocations due to a car accident. When an individual receives a hip dislocation, there is an incidence rate of 95% that they will receive an injury to another part of their body as well. 46–84% of hip dislocations occur secondary to traffic accidents, the remaining percentage is due based on falls, industrial accidents or sporting injury.