Intravascular hemolysis describes hemolysis that happens mainly inside the vasculature. As a result, the contents of the red blood cell are released into the general circulation, leading to hemoglobinemia and increasing the risk of ensuing hyperbilirubinemia. Mechanism
Intravascular hemolysis is the state when the red blood cell ruptures as a result of the complex of complement autoantibodies attached (fixed) on the surfaces of RBCs attack and rupture RBCs membranes, or a parasite such as Babesia exits the cell that ruptures the RBCs membrane as it goes.Upon RBCs rupture, components of which are released and circulating in the blood plasma.These components comprise hemoglobin and others. At this stage, the hemoglobin is called free hemoglobin. Free hemoglobin (also called naked hemoglobin) is the un-bound hemoglobin that is not enclosed in the red blood cell. The naked hemoglobin is devoid of its anti-oxidant sentries that are normally available within the RBC. Free hemoglobin is thus vulnerable to be oxidized.When the serum concentration of free hemoglobin is within the physiologic range of haptoglobin, the potential deleterious effects of free hemoglobin are prevented because haptoglobin will bind to "free hemoglobin" forming a complex of "free hemoglobin-haptoglobin" evidenced by reduced amount of haptoglobin. However, during hyper-hemolytic conditions or with chronic hemolysis, haptoglobin is depleted so the remaining free hemoglobin readily distribute to tissues where it might be exposed to oxidative conditions, thus some of the ferrous heme (FeII), the oxygen-binding component of hemoglobin, of the free hemoglobin are oxidized and becoming met-hemoglobin (ferric hemoglobin).
benzydamine mouthwash) to reduce pain
Topical (gels, creams or inhalers) or systemic steroids may be used to reduce inflammation
An antifungal drug may be used to prevent oral candidiasis developing in those who use prolonged steroids
People with mouth ulcers may prefer to avoid hot or spicy foods, which can increase the pain
Self-inflicted ulceration can be difficult to manage, and psychiatric input may be required in some people: 53 
For recurrent ulcers, vitamin B12 has been shown to be effective

Epidemiology
Oral ulceration is a common reason for people to seek medical or dental advice. : 52  A breach of the oral mucosa probably affects most people at various times during life. For a discussion of the epidemiology of aphthous stomatitis, see the epidemiology of aphthous stomatitis. See also
Sodium dodecyl sulfate

References
External links

 Learning materials related to Oral ulceration at Wikiversity
Mouth ulcer at Curlie