Studies have shown significant hepatotoxicity is uncommon in patients who have taken greater than normal doses over 3 to 4 days. In adults, a dose of 6 grams a day over the preceding 48 hours could potentially lead to toxicity, while in children acute doses above 200 mg/kg could potentially cause toxicity. Acute paracetamol overdose in children rarely causes illness or death, and it is very uncommon for children to have levels that require treatment, with chronic larger-than-normal doses being the major cause of toxicity in children.Intentional overdosing (self-poisoning, with suicidal intent) is frequently implicated in paracetamol toxicity. In a 2006 review, paracetamol was the most frequently ingested compound in intentional overdosing.In rare individuals, paracetamol toxicity can result from normal use. This may be due to individual ("idiosyncratic") differences in the expression and activity of certain enzymes in one of the metabolic pathways that handle paracetamol (see paracetamols metabolism). Risk factors
A number of factors can potentially increase the risk of developing paracetamol toxicity. Chronic excessive alcohol consumption can induce CYP2E1, thus increasing the potential toxicity of paracetamol. In one study of patients with liver injury, 64% reported alcohol intakes of greater than 80 grams a day, while 35% took 60 grams a day or less. Whether chronic alcoholism should be considered a risk factor has been debated by some clinical toxicologists. For chronic alcohol users, acute alcohol ingestion at the time of a paracetamol overdose may have a protective effect. For non-chronic alcohol users, acute alcohol consumption had no protective effect.
Websters definition of "mute", on the other hand, gives the adjectival meaning as "unable to speak", whereas one of its usages as a noun is "a person who cannot speak ... sometimes offensive".In informal American English the terms "mute" and "dumb" are sometimes used to refer to other hearing people in jest, to chide, or to invoke an image of someone who refuses to employ common sense or who is unreliable. In the past deaf-mute was used to describe deaf people who used sign language, but in modern times, the term is frequently viewed today as offensive and inaccurate. From antiquity (as noted in the Code of Hammurabi) until recent times, the terms "deaf-mute" and "deaf and dumb" were sometimes considered analogous to "stupid" by some hearing people. The simple identity of "deaf" has been embraced by the community of signing deaf people since the foundations of public deaf education in the 18th century and remains the preferred term of reference or identity for many years. Within the deaf community there are some who prefer the term "Deaf" (upper-case D) to "deaf" (lower-case) as a description of their status and identity. Jewish law
Classification as a deaf-mute has a particular importance in Jewish law. Because historically it was thought impossible to teach or communicate with them, deaf-mutes were not moral agents, and therefore were unable to own real estate, act as witnesses, or be punished for any crime. However, today when techniques for educating deaf people are known, they are no longer classed as such.