In a small study of factory workers in good health, wearing compression garments helped to reduce edema and the pain associated with edema. A small study of runners found that wearing knee-high compression stockings while running significantly improved performance.The circumference of the calf has been used to estimate selected health risks. In Spain, a study of 22,000 persons 65 or older found that a smaller calf circumference was associated with a higher risk of undernutrition. In France, a study of 6265 persons 65 or older found an inverse correlation between calf circumference and carotid plaques.Calf augmentation and restoration is available, using a range of prosthesis devices and surgical techniques

Training and Exercise
The calves can be isolated by performing movements involving plantarflexion (pointing the toes down). The two major categories of calf exercises are those that maintain an extended knee, and those that maintain a flexed knee. The first category includes movements such as standing calf raises, donkey calf raises and stair calves. The second category includes movements that maintain a bent knee, such as seated calf raises. Movements with a straight knee will target the gastrocnemius muscle more, and movements with a bent-knee will target the soleus muscle more. However, both variations will target both muscles to a large degree. As the calf muscles are predominantly slow-twitch, they should be trained in a moderate to high repetition range. All repetition ranges offer their own benefits, and as such, calf training should be done in the 5-10 repetition range, the 10-20 repetition range, and the 20-30 repetition range.
If the adrenal glands appear not to be working then tetracosactide injection can be given to check whether the problem is due to diseased or damaged adrenals or due to lack of pituitary ACTH. Tetracosactide stimulates the release of corticosteroids such as cortisol from the adrenal glands, and is used for the ACTH stimulation test to assess adrenal gland function. : 271

Chemistry
The synthetic form consists of the first 24 (of a total of 39) amino acids of ACTH and retains full function of the parent peptide. : 1165

Manufacturing
History
Society and culture
Approved forms
In the US, available forms of animal-derived corticotrophin have included:

Cortiocotrophin derived from pituitary glands from pigs, in a gel formulation as well as in a zinc hydrochloride formulation, each first approved in the US in 1955 and subsequently discontinued. In September 2015 ANI Pharmaceuticals and Merck & Co. agreed that ANI would purchase NDA 009854 and NDA 008975 and related trademarks and other assets related to these two versions of corticotrophin from Merck for $75M and ongoing royalties; the transaction closed in January 2016. As of November 2016 ANI was preparing its supplemental NDA to get approval to re-introduce this formulation; in 2015 ANI estimated that the US market for these products was about $1 billion per year, based on sales of Acthar gel. Corticotrophin, first approved in 1952 and subsequently discontinued; as of January 2017 this NDA was under control of Parkedale, a subsidiary of King Pharmaceuticals which is in turn a subsidiary of Pfizer.