Mesuximide (or methsuximide, methosuximide) is a succinimide anticonvulsant medication. It is sold as a racemate by Pfizer under the tradenames Petinutin (Switzerland) and Celontin (United States). The therapeutic efficacy of methosuximide is largely due to its pharmacologically active metabolite, N-desmethylmethosuximide, which has a longer half-life and attains much higher plasma levels than its parent. Medical use
is indicated for the control of absence seizures that are refractory to other drugs. == References ==
lower forced expiratory volume per second (FEV1) predicted, impaired walking capacity or increased number of exacerbations) as evaluated by a healthcare professional experienced in the treatment of alpha1-proteinase inhibitor deficiency.The most common side effects include dizziness, headache, dyspnoea (shortness of breath) and nausea. Allergic reactions have been observed during treatment, some of which were severe.Aerosolized-augmented A1AT therapy is under study. This involves inhaling purified human A1AT into the lungs and trapping the A1AT into the lower respiratory tract. However, inhaled A1AT may not reach the elastin fibers in the lung where elastase injury occurs. Further study is currently underway. Recombinant alpha-1 antitrypsin is not yet available for use as a medication but is under development. History
Axelsson and Laurell first investigated the possibility of allelic variants of A1AT leading to disease in 1965. See also
Alpha 1-antichymotrypsin, another serpin that is analogous for protecting the body from excessive effects of its own inflammatory proteases

References
Further reading
External links
"Alpha 1-Antitrypsin". Drug Information Portal. U.S. National Library of Medicine. The MEROPS online database for peptidases and their inhibitors: I04.001
Proteopedia: Alpha-1-antitrypsin
Human SERPINA1 genome location and SERPINA1 gene details page  in the UCSC Genome Browser.