Fluid restriction does not help people who have nocturia due to gravity-induced third spacing of fluid because fluid is mobilized when they lie in a reclining position. Compression stockings may be worn through the day to prevent fluid from accumulating in the legs, unless heart failure or another contraindication is present. Drugs that increase the passing of urine can help decrease the third spacing of fluid, but they could also increase nocturia. Medications
ADH replacements such as Desmopressin and Vasopressin
Selective Alpha-1 blockers are the most commonly used medicine to treat BPH. Alpha-1 blockers are first line treatment for the symptoms of BPH in men. Doxazosin, terazosin, alfuzosin and tamsulosin have all been well established in treatment to reduce lower urine tract symptoms (LUTS) caused by benign prostatic hyperplasia. They are all believed to be similarly effective for this purpose. First generation alpha-1 blockers, like prazosin are not recommended to treat lower urinary tract symptoms because of their blood-pressure-lowering effect. Later generation drugs in this class are used for this purpose. In some cases alpha-1 blockers have been used in combined therapy with 5-alpha reductase blockers. Dutasteride and tamsulosin are on the market as combined therapy and results have shown that they improve symptoms significantly versus monotherapy. If urinary tract infection is causative, it can be treated with urinary antimicrobials. Antimuscarinic agents such as oxybutynin, tolterodine, solifenacin are especially used in patients who suffer from nocturia due to an overactive bladder and urgency incontinence because they help bladder contractility.
Turoctocog alfa pegol
In February 2019, the FDA approved antihemophilic factor (recombinant), glycopegylated-exei (turoctocog alfa pegol) (Esperoct) for the treatment of hemophilia A. Turoctocog alfa pegol was approved for medical use in the European Union in June 2019. References
External links
"Turoctocog alfa". Drug Information Portal. U.S. National Library of Medicine. "Turoctocog alfa pegol". Drug Information Portal. U.S. National Library of Medicine.