In typical T-cell recognition, an antigen is taken up by an antigen-presenting cell, processed, expressed on the cell surface in complex with class II major histocompatibility complex (MHC) in a groove formed by the alpha and beta chains of class II MHC, and recognized by an antigen-specific T-cell receptor. This results in polyclonal T-cell activation. Superantigens do not require processing by antigen-presenting cells but instead, interact directly with the invariant region of the class II MHC molecule. In patients with TSS, up to 20% of the bodys T-cells can be activated at one time. This polyclonal T-cell population causes a cytokine storm, followed by a multisystem disease. Risk factors
A few possible causes of toxic shock syndrome are:
Cuts or open wounds on the skin
Surgical wounds
Viral infections (e.g.
Perifollicular fibroma is a cutaneous condition, a benign tumor usually skin colored, most often affecting the face and upper trunk. : 674

See also
Birt–Hogg–Dubé syndrome
List of skin conditions


== References ==