Elderly users of diflunisal are at greater risk for serious GI events. Increased risk of GI events including bleeding, ulceration, and stomach or intestine perforation. Abdominal pain or cramps
Constipation
Gas
Diarrhea
Nausea and vomiting
Dyspepsia

Cardiovascular
Irregular heart beat
Possible increased risk of serious and potentially fatal cardiovascular thrombotic events, MI, and stroke
Risks may increase with duration of use and for cardiovascular disease history

Ear, nose, throat, and eye
Ringing in the ears
Yellowing of eyes

Central nervous system
Drowsiness
Dizziness
Headache
Insomnia
Fatigue
Somnolence
Nervousness

Skin
Swelling of the feet, ankles, lower legs, and hands
Yellowing of skin
Rash
Ecchymosis

Contraindications
Hypersensitivity to aspirin/NSAID-induced asthma or urticaria
Aspirin triad
3rd trimester pregnancy
Coronary artery bypass surgery (peri-op pain)

Cautions
Overdose
Deaths that have occurred from diflunisal usually involved mixed drugs and or extremely high dosage. The oral LD50 is 500 mg/kg. Symptoms of overdose include coma, tachycardia, stupor, and vomiting. The lowest dose without the presence of other medicines which caused death was 15 grams. Mixed with other medicines, a death at 7.5 grams has also occurred. Diflunisal usually comes in 250 or 500 mg, making it relatively hard to overdose by accident. References
External links
Diflunisal: MedlinePlus Drug Information
Dolobid Prescribing Information (manufacturers website)
Dolobid Medication Guide (manufacturers website)
"Single dose oral diflunisal for acute postoperative pain in adults"
Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cholangitis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis. Cause
Cholestasis means "the slowing or stopping of bile flow" which can be caused by any number of diseases of the liver (which produces the bile), the gallbladder (which stores the bile), or biliary tract (also known as the biliary tree, the conduit that allows the bile to leave the liver and gallbladder and enter the small intestine). When this occurs, conjugated bilirubin and the waste products that usually would be cleared in bile reflux back into the bloodstream. This causes a primarily conjugated hyperbilirubinemia and jaundice; the liver conjugates the bile to make it water-soluble and because the bile has already been processed by the liver, when it gets backed up because of a blockage and is refluxed into the blood, the blood will have high levels of conjugated bilirubin. This is in contrast to primarily unconjugated hyperbilirubinemia which is the water-insoluble form that is bound to serum albumin; the liver has not had a chance to conjugate the bilirubin yet and can be caused either because too much unconjugated bilirubin is made (such as in massive hemolysis or ineffective erythropoiesis) or because too little is conjugated (Gilberts disease or Crigler–Najjar syndrome). Unconjugated hyperbilirubinemia does not typically cause pruritus.