: 918–919

Chemistry
Synthesis
Analogous to fenamic acid, this compound may be made from 2-chlorobenzoic acid and 2,3-dimethylaniline. Society and culture
Availability and pricing
Mefenamic acid is generic and is available worldwide under many brand names.In the US, wholesale price of a weeks supply of generic mefenamic acid has been quoted as $426.90 in 2014. Brand-name Ponstel is $571.70. In contrast, in the UK, a weeks supply is £1.66, or £8.17 for branded Ponstan. Research
While studies have been conducted to see if mefenamic acid can improve behavior in transgenic mouse models of Alzheimers disease there is little evidence that mefenamic acid or other NSAIDs can treat or prevent Alzheimers in humans; clinical trials of NSAIDs other than mefenamic acid for treatment of Alzheimers have found more harm than benefit.A small controlled study of 28 human subjects showed improved cognitive impairment using mefenamic acid non-steroidal anti-inflammatory therapy. See also
Niflumic acid

References
Sources
MedlinePlus Drug Information: Mefenamic Acid. Last accessed September 28, 2005. Ponstel Pharmacology, Pharmacokinetics, Studies, Metabolism - Mefenamic Acid - RxList Monographs. Last accessed September 28, 2005. Consumption of NSAIDs and the Development of Congestive Heart Failure in Elderly Patients
NSAIDs May Increase Risk for Worsening Heart Failure
On the other hand, the post-partal synthesis of PGE2 in newborns is considered one cause of patent ductus arteriosus.The aerosol form of PGE2 serves as a bronchodilator, but its use in this setting is limited by the fact that it also causes coughing.PGE2, similarly to PGE1, acts as a direct vasodilator by acting on smooth muscle to cause dilation of blood vessels. In addition, PGE2 inhibits platelet aggregation.PGE2 also suppresses T cell receptor signaling and proliferation, and may play a role in resolution of inflammation. In addition, PGE2 limits the immune response by  preventing B-lymphocyte differentiation and their ability to present antigens. Central and peripheral nervous systems effects
Prostaglandin E2 (PGE2) has a variety of functions within the central nervous system and peripheral nervous system. When PGE2 interacts with EP3 receptors, it increases body temperature, resulting in fever. PGE2 is also a predominant prostanoid that contributes to inflammation via enhancing edema and leukocyte infiltration from increased vascular permeability (allowing more blood flow into an inflamed area of the body) when acting on EP2 receptors. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) blocks the activity of COX-2, resulting in a decrease of PGE2 production. NSAIDs blocking COX-2 and decreasing the production of PGE2 remediates fever and inflammation.Additionally, PGE2 acting on EP1 and EP4 receptors are a component in feeling pain via inflammatory nociception. When PGE2 binds to EP1 and EP4 receptors, an increase in excitability via cation channels as well as inhibition of hyperpolarizing potassium (K+) channels, increase membrane excitability.