Dosages vary according to the age groups and the individual condition of the person, body weight, and compliance to the medication and diet. Other predictors of the required dosage are sex, body mass index, deiodinase activity (SPINA-GD), and etiology of hypothyroidism. Annual or semiannual clinical evaluations and TSH monitoring are appropriate after dosing has been established. Levothyroxine is taken on an empty stomach about half an hour to an hour before meals. As such, thyroid replacement therapy is usually taken 30 minutes prior to eating in the morning. For patients with trouble taking levothyroxine in the morning, bedtime dosing is effective, as well. A study in 2015 showed greater efficacy of levothyroxine when taken at bedtime. Doses of levothyroxine that normalize serum TSH may not normalize abnormal levels of LDL cholesterol and total cholesterol.Poor compliance in taking the medicine is the most common cause of elevated TSH levels in people receiving appropriate doses of levothyroxine. 50 and older
For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should not be initiated at the full replacement dose. Since thyroid hormone increases the hearts oxygen demand by increasing heart rate and contractility, starting at higher doses may cause an acute coronary syndrome or an abnormal heart rhythm. Pregnancy and breastfeeding
Hypothyroidism is common among pregnant women. A nationwide cohort study showed that 1.39% of all pregnant women in 2010 in Denmark received a prescription of levothyroxine during pregnancy.
Yaz may refer to:

People
Yazmith Bataz (born 1972), Mexican sprinter
Yaz Mubarakai (born 1975), Australian politician
Carl Yastrzemski (born 1939), American Hall-of-Fame baseball player
Mike Yastrzemski (born 1990), American professional baseball player, grandson of Carl

Other uses
Yaz culture, an early Iron Age culture of Bactria and Margiana, c. 1500-1100 BC
Yaz-class river patrol craft, Russian Coast Guard vessels
YAZ, IATA code for Tofino Airport in Tofino, British Columbia, Canada
yaz, ISO 639-3 code for the Yakö language, spoken by the Yakö people of Nigeria
Yaz (band) or  Yazoo, an English synth-pop band
Yaz Pistachio, a female character from the comic strip Bloom County
Yaz (drug), a brand name for a birth control pill containing drospirenone that may also be used for other indications
YAZ, a programmer toolkit for development of Z39.50 clients and servers

See also
Yazz (born 1960), pseudonym used by English singer Yasmin Evans
Yazz The Greatest, a stage name of American actor and rapper Bryshere Y. Gray