253): early Christian theologian, allegedly castrated himself based on his reading of the Gospel of Matthew 19:12 ("For there are eunuchs, who were born so from their mothers womb: and there are eunuchs, who were made so by men: and there are eunuchs, who have made themselves eunuchs for the kingdom of heaven. He that can take, let him take it."). Despite the fact that the early Christian theologian Tertullian wrote that Jesus was a eunuch, there is no corroboration in any other early source. (The Skoptsy did, however, believe it to be true.) Chusdazat (died 344): He served King Shapur II, who killed him for declaring his Christian identity. Dorotheus of Tyre (255–362): A bishop who attended the Council of Nicaea, was exiled by Diocletian and Julian, and was martyred. Eutropius (died 399): only eunuch known to have attained the highly distinguished office of Roman Consul. Chrysaphius (died 450): chief minister of Eastern Roman Emperor Theodosius II, architect of imperial policy towards the Huns. Narses (478–573): general of Byzantine emperor Justinian I, responsible for destroying the Ostrogoths in 552 at the Battle of Taginae in Italy and reconquering Rome for the empire. Solomon (480s/490s–544): general and governor of Africa under Justinian I.
Gao Lishi (684–762): a loyal and trusted friend of Tang emperor Xuanzong. Li Fuguo (704–762): Tang eunuch who began another era of eunuch rule. Yu Chaoen (722–770): Tang eunuch who began his career as army supervisor. Staurakios (died 800): chief associate and minister of the Byzantine empress Irene of Athens.
Some chemical warfare agents, known as blister agents or vesicants, cause large, painful blisters wherever they contact skin; an example is mustard gas. Blood blister
A blood blister usually forms when a minute blood vessel close to 
the surface of the skin ruptures (breaks), and blood leaks into a tear between the layers of skin. This can happen if the skin is crushed, pinched or aggressively squeezed. Medical conditions
There are also a number of medical conditions that cause blisters. The most common are chickenpox, herpes, impetigo, and a form of eczema called dyshidrosis. Other, much rarer conditions that cause blisters include:

Bullous pemphigoid: a skin disease that causes large, tightly filled blisters to develop, usually affecting people over the age of 60. Pemphigus: a serious skin disease in which blisters develop if pressure is applied to the skin; the blisters burst easily, leaving raw areas that can become infected. Dermatitis herpetiformis: a skin disease that causes intensely itchy blisters, usually on the elbows, knees, back and buttocks. The blisters usually develop in patches of the same shape and size on both sides of the body. Chronic bullous dermatosis: a disease that causes clusters of blisters on the face, mouth or genitals. Cutaneous radiation syndrome
Epidermolysis bullosa

Pathophysiology
Friction blisters
Friction blisters are caused by excess shear stress between the bottom and surface of the skin and the body. The strata of skin around the stratum spinosum are most susceptible to shear. As the stratum spinosum tears away from the connecting tissues below, plasma from the cells diffuses out.