Proximal myopathy, inflammatory polyarthritis, central nervous system symptoms, esophageal aperistalsis, and hoarseness are among the notable systemic symptoms. If viscera is involved, the disease will be fatal. The dermatoneuro syndrome is a rare neurological complication of the disease presenting with fever, seizures and altered mental status. Diagnosis
Classification
Papular mucinosis may be divided into several types or variants:
Acral persistent papular mucinosis
Self-healing papular mucinosis
Papular mucinosis of infancy
Cutaneous mucinosis of infancy
Nodular lichen myxedematosus
Localized lichen myxedematosus
Discrete papular lichen myxedematosus

Treatment
There is no effective treatment for this condition. It has been reported that clearance of lesions can be done with melphalan and cyclophosphamide alone or in combination with prednisone. Both isotretinoin and etretinate have also been shown to improve the conditions. All medications listed can cause adverse symptoms, with isotretinoin and etretinate particularly dangerous since they are both teratogens. Other attempted treatments include interferon-alpha, cyclosporine, PUVA photochemotherapy, electron-beam therapy, IVIg and dermabrasion. However, the overall prognosis for the disease is poor. There are reported instances of remission of the disease when treated with a combination of Revlimid and Dexamethasone over a 24-month period. Incidence
Papular mucinosis affects adults of both sexes equally and appears between ages 30 and 80. Recently, it has been reported in patients infected with the HIV/AIDS virus. It has also been associated with certain paraproteinemias such as IgG lambda paraproteinemia. See also
List of cutaneous conditions

Notes
References
"What is Papular mucinosis? ", The Star (Malaysia), December 20, 2006. "Papular Mucinosis", Dermatology Online Journal Vol. 7 No. 2. == External links ==
Military use
The United States Air Force uses zaleplon as one of the hypnotics approved as a "no-go pill" to help aviators and special-duty personnel sleep in support of mission readiness (with a four-hour restriction on subsequent flight operation). "Ground tests" are required prior to authorization being issued to use the medication in an operational situation. The other hypnotics used as "no-go pills" are temazepam and zolpidem, which both have longer mandatory recovery periods. See also


== References ==