A total of 683 patients were enrolled in all of the multiple dose trials, with 57% of the participants being women. These studies also looked at self reported pain intensities over a 5-day period of multiple dosing. In these studies, patients were either given the trial drug Vicoprofen or one of two an active controls: codeine with acetaminophen (Tylenol #3) or oxycodone with acetaminophen (Percocet), depending on the trial. Patients were allowed to take a dose as needed but no more than every 4 to 6 hours for up to 5 days. These trials measured efficacy based on parameters including self reported pain scores, number of doses used, and duration of treatment. Society and culture
Cost
The average wholesale price (AWP) of generic Vicoprofen varies based on the strength of the preparation. Pricing data gathered from Lexicomp in October 2017 indicates the AWP for a 100 count bottle of 7.5 mg/200 mg strength to be $114.62, a 100 count of 5 mg/200 mg strength to be $356.62 and a 100 count of 10 mg/200 mg strength to be $470.35. These prices are all for generic equivalents of Vicoprofen. Utilization
In 2003, at the time of the approval announcement for the first generic equivalent, it was reported that annual sales of brand name Vicoprofen totaled $104 million. According to IMS, the hydrocodone/ibuprofen tablets 7.5 mg/200 mg, had an estimated market size of $15.7 million for the 12 months preceding May 2016. See also
Fentanyl/fluanisone
Hydrocodone/aspirin
Hydrocodone/paracetamol
Morphine/naltrexone
Oxycodone/aspirin
Oxycodone/ibuprofen
Oxycodone/naloxone
Oxycodone/paracetamol

References
External links
"Hydrocodone tartrate mixture with ibuprofen". Drug Information Portal. U.S. National Library of Medicine.
Hypergonadism is a condition where there is a hyperfunction of the gonads. It can manifest as precocious puberty, and is caused by abnormally high levels of testosterone or estrogen, crucial hormones for sexual development. In some cases, it may be caused by a tumor, which can be malignant, but is more commonly benign. Anabolic steroids may also be a major cause of high androgen and estrogen functional activity. Other possible causes include head injuries and brain inflammatory diseases. Hypergonadism may contribute to symptoms such as precocious puberty and abnormal facial hair growth in females. Symptoms
Men and women exhibit different symptoms for hypergonadism. A few of the symptoms that men can experience are increased sex drive, early balding, excessive muscle mass, and acne. Women can have symptoms such as, increased growth of facial hair, deepened voice, coarse body hair, and an irregular menstrual cycle. See also
Hypergonadotropic hypergonadism
Hyperandrogenism and hyperestrogenism
Hypothalamus, pituitary gland, and HPG axis
GnRH and gonadotropins (FSH and LH)
Hypogonadism (hypoandrogenism and hypoestrogenism)


== References ==