A review of functional neuroimaging studies reported reduced activations in "bottom up" limbic region and increased activations in "top down" cortical regions which may play a role in restrictive eating.Compared to controls, people who have recovered from anorexia show reduced activation in the reward system in response to food, and reduced correlation between self reported liking of a sugary drink and activity in the striatum and anterior cingulate cortex. Increased binding potential of 11C radiolabelled raclopride in the striatum, interpreted as reflecting decreased endogenous dopamine due to competitive displacement, has also been observed.Structural neuroimaging studies have found global reductions in both gray matter and white matter, as well as increased cerebrospinal fluid volumes. Regional decreases in the left hypothalamus, left inferior parietal lobe, right lentiform nucleus and right caudate have also been reported in acutely ill patients. However, these alterations seem to be associated with acute malnutrition and largely reversible with weight restoration, at least in nonchronic cases in younger people. In contrast, some studies have reported increased orbitofrontal cortex volume in currently ill and  in recovered patients, although findings are inconsistent. Reduced white matter integrity in the fornix has also been reported. Diagnosis
A diagnostic assessment includes the persons current circumstances, biographical history, current symptoms, and family history. The assessment also includes a mental state examination, which is an assessment of the persons current mood and thought content, focusing on views on weight and patterns of eating.
Lipoblastoma is a type of rare, subcutaneous, benign, fatty tumor, found in infants, and children, more common in males with tendency of local recurrence. Local recurrence can happen in up to 80% of incompletely resected tumours. Therefore, complete surgical resection is required to prevent recurrence. It arises from embyronic white fat that is rapidly enlarging. Most common locations are at the trunk and extremities.Types include:
Benign lipoblastomatosis, a tumor, also known as an embryonic lipoma, which usually occurs in children under three years old. This is the tumor of brown fat cells. Myxoid lipoblastoma, a cutaneous condition characterized by excess mucin

Specimen
Macroscopic
Grossly, it has a pale yellow, myxoid cut surface with small cystic foci. Microscopic
It has lobules consists of immature adipose tissue separated by fibrous septa and lipoblasts at different stages of maturation, without atypia or mitosis. Plexiform capillary network and mature adipose tissue are seen at the central part of the lobule. See also
Lipoblast
Lipoma


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