The American Academy of Orthopaedic Surgeons report approximately 12 million visits to doctors offices each year are due to back pain. Missed work and disability related to low back pain costs over $50 billion each year in the United States. In the United Kingdom in 1998, approximately £1.6 billion per year was spent on expenses related to disability from back pain. References
External links

Back and spine at Curlie
Handout on Health: Back Pain at National Institute of Arthritis and Musculoskeletal and Skin Diseases
Qaseem A, Wilt TJ, McLean RM, Forciea MA (April 2017). "Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians". Annals of Internal Medicine. 166 (7): 514–30. doi:10.7326/M16-2367. PMID 28192789. Non-specific Back Pain Guidelines 2017 – Kaiser Foundation Health Plan of Washington Archived
Therefore, it is not expected to react with CYP2C19 substrates like theophylline, warfarin, diazepam, and phenytoin. However, the acid-suppression effects of rabeprazole, like other PPIs, may interfere with the absorption of drugs that require acid, such as ketoconazole and digoxin.There is some evidence that omeprazole and esomeprazole, two medications in the same class as rabeprazole, can disturb the conversion of an anticoagulant medication called clopidogrel to its active metabolite. However, because this is thought to be mediated by the effect of omeprazole and esomeprazole on CYP2C19, the enzyme that activates clopidogrel, this drug interaction is not expected to occur as strongly with rabeprazole. However, whether the effect of omeprazole and esomeprazole on clopidogrels metabolism actually leads to poor clinical outcomes is still a matter of intense debate among healthcare professionals.Clinically serious drug-drug interactions may involve the acid-suppression effects of rabeprazole. For example, rabeprazole should not be used concomitantly with rilpivirine, an anti-HIV therapy, which requires acid for absorption. Lowered plasma concentrations of rilpivirine could lead to progression of HIV infection. Other drugs that require acid for absorption include antifungal drugs like ketoconazole and itraconazole, digoxin, iron, mycophenolate, and tyrosine kinase inhibitors like erlotinib, dasatinib, and nilotinib. There is no clinically relevant drug interaction between rabeprazole and antacids. Food-drug interactions
Food does not affect the amount of rabeprazole that enters the body, but it does delay its onset of effect by about 1.7 hours.