: 378  Obesity may be more likely to present among those with severe OI, (especially after the age of 20,) and can, in some, cause further declines in mobility. : 371, 373 Tilt table whole body vibration may also be done to increase the mobility of long-term immobilized (bedridden) patients with OI; in at least two cases it helped bedridden children to be able to sit upright. Teeth
More than 1 in 2 people with OI also have dentinogenesis imperfecta (DI)—a congenital abnormality in the formation of dentin, one of the four major components of the human tooth. Dental treatment may pose as a challenge as a result of the various deformities, skeletal and dental, due to OI. Children with OI should go for a dental check-up as soon as their teeth erupt; this may minimize tooth structure loss as a result of abnormal dentine, and they should be monitored regularly to preserve their teeth and oral health.Many people with OI are treated with bisphosphonates, and there are several possible related complications with dental procedures, for example, medication-related osteonecrosis of the jaw (MRONJ). However, no report of bisphosphonate-related MRONJ in either a child or adult with OI was found in a 2016 Cochrane review of the safety and efficacy of bisphosphonates for OI. In development
Monoclonal antibodies
Monoclonal antibodies have long been considered for OI, but as of 2021, such therapy has not been approved for OI, neither in the European Union nor in the United States. Thus, it is unclear whether they are safe or effective.
It can provide stability and support during the time (typically 8–12 weeks) needed for the cervical bones to heal. Surgery
Surgery may be needed to stabilize the neck and relieve pressure on the spinal cord. A variety of surgeries are available depending on the injury. Surgery to remove a damaged intervertebral disc may be done to relieve pressure on the spinal cord. The discs are cushions between the vertebrae. After the disc is removed, the vertebrae may be fused together to provide stability. Metal plates, screws, or wires may be needed to hold vertebrae or pieces in place. History
Arab physician and surgeon Ibn al-Quff (d. 1286 CE) described a treatment of cervical fractures through the oral route in his book Kitab al-ʿUmda fı Ṣinaʿa al-Jiraḥa (Book of Basics in the Art of Surgery). See also
Brown-Séquard syndrome
Cervical dislocation
Internal decapitation
Spinal cord injury

References
External links
Van Waes OJ, Cheriex KC, Navsaria PH, van Riet PA, Nicol AJ, Vermeulen J (January 2012). "Management of penetrating neck injuries". The British Journal of Surgery. 99 (Suppl 1): 149–154. doi:10.1002/bjs.7733. hdl:1765/37154. PMID 22441870. S2CID 205512500.