Pica or PICA may refer to:

Biology
Pica (disorder), an abnormal appetite for earth and other non-foods
Posterior inferior cerebellar artery, a major artery supplying blood to the cerebellum

Organisms
Aechmea Pica, a hybrid cultivar in the Bromeliad family of flowering plants
Pica (genus), a genus of magpie
Pika, a small mammal (archaic spelling "pica")

Organizations
OCLC PICA, a library automation company
Palestine Jewish Colonization Association, known by its Yiddish acronym as PICA
Pennsylvania Intergovernmental Cooperation Authority, a governmental agency in Philadelphia, Pennsylvania
Perth Institute of Contemporary Arts, Western Australia
Pica Press, a publishing imprint
Pittsburgh Intergovernmental Cooperation Authority, a governmental agency in Pittsburgh, Pennsylvania
Portland Institute for Contemporary Art, Oregon

People
Antonio Pica (1923–2014), Spanish actor
Joe Pica (1923–1973), American pianist
Pierre Pica (born 1951), French linguist
Teresa P. Pica (1945–2011), American educator
Tina Pica (1884–1968), Italian actress
Yamantaka Eye (born 1964), Japanese artist known as DJ Pica Pica Pica (DJ 光光光)

Places
Pica, Chile, an oasis town in the Atacama Desert of Chile
Limón de Pica, a lime variety from Pica
Pica, Cumbria, a village in northwest England
Pica, Jayuya, Puerto Rico, a barrio

Technology
Acer PICA, a system logic chipset introduced in 1993
Phenolic-impregnated carbon ablator, a spacecraft heat shield material
Pre-integrated COF APM, part of the International Space Stations Columbus module systems

Other uses
Pica, an alternative name for the grape Merille
Pica, a lance used by a picador in bullfighting
Pica (typography), a unit of length used in typesetting and document layout
píča, a rude expression for a vagina in the Czech Republic and Slovakia

See also
Pico (disambiguation)
Piga (disambiguation)
Pika (disambiguation)
Indeed, one suggested use for lofexidine is to ease withdrawal symptoms of methadone dependence. Its use is approved in the United States for up to 14 days. Other clinical uses
The possibility of using lofexidine to treat alcohol withdrawal symptoms has been investigated, and has not yet been shown to be an effective treatment. It is also used in treatment of cases with postmenopausal hot flashes. Special populations
Lofexidines safety in pregnancy or in the setting of breastfeeding are unknown. Caution is warranted if chronic kidney impairment is present. Adverse effects
Adverse effects that have occurred after taking lofexidine include the following:
Slow heart rate
Dizziness
Sleepiness
Mouth dryness
Low blood pressure
QT prolongationIn addition, people may experience a sudden jump in blood pressure after stopping lofexidine. Overdose
The LD50 of lofexidine is above 77 mg/kg in animals. Studies of high-dose, single administrations of lofexidine proved tolerable for animals, but repeat administration induced symptoms consistent with toxicity. In studies on mice, rats, and dogs, these included ataxia, somnolence, and tremors. It is expected that an overdose of lofexidine would result in symptoms akin to its pharmacological side effects in humans, such as bradycardia and hypotension. Interactions
Many drug-drug interactions with lofexidine are possible. QT prolongation
Lofexidine prolongs the QT interval, which can result in a severe interaction (torsade de pointes) when combined with other drugs that also prolong the QT interval. Patient-specific characteristics that increase the risk for a clinically significant drug-drug interaction include:
increasing age
female sex
cardiac disease
electrolyte disturbances (low blood potassium)As a result, there are many QT-prolonging drugs that may interact with lofexidine.