The reason given: "Based on the collective evidence from several large cardiovascular outcome trials, the Agency has concluded that the totality of the scientific evidence no longer supports the conclusion that a drug-induced reduction in triglyceride levels and/or increase in HDL-cholesterol levels in statin-treated patients results in a reduction in the risk of cardiovascular events." The drug company discontinued the drugs. Contraindications
Prescription immediate release (Niacor) and extended release (Niaspan) niacin are contraindicated for people with either active or a history of liver disease because both, but especially Niaspan, have been associated with instances of serious, on occasion fatal, liver failure. Both products are contraindicated for people with existing peptic ulcer disease, or other bleeding problems because niacin lowers platelet count and interferes with blood clotting. Both products are also contraindicated for women who are pregnant or expecting to become pregnant because safety during pregnancy has not been evaluated in human trials. These products are contraindicated for women who are lactating because it is known that niacin is excreted into human milk, but the amount and potential for adverse effects in the nursing infant are not known. Women are advised to either not nurse their child or discontinue the drug. High-dose niacin has not been tested or approved for use in children under 16 years. Adverse effects
The most common adverse effects of medicinal niacin (500–3000 mg) are flushing (e.g., warmth, redness, itching or tingling) of the face, neck and chest, headache, abdominal pain, diarrhea, dyspepsia, nausea, vomiting, rhinitis, pruritus and rash.
According to one commentator, Americans use pauses such as "um" or "em", the Irish commonly use the pause "em", the British say "uh" or "eh", the French use "euh", the Germans say "äh" (pronounced eh or er), the Dutch use "eh", Japanese use "ā", "anō" or "ēto", the Spanish say "ehhh" (also used in Hebrew) and "como" (normally meaning like), and Latin Americans but not the Spanish use "este" (normally meaning this). Besides "er" and "uh", the Portuguese use "hã" or "é". In Mandarin, "那个(nà gè)" and "这个(zhè ge)" are used, meaning "that" or "this", respectively. Arabic speakers say "يعني", the pronunciation of which is close to "yaani", [jæʕni] or [jaʕni], (literally he means, there is no grammatical gender-neutral third person) and Turkish say "şey" in addition to "yani" (without the [ʕ] found in Arabic) and "ııı".Despite the differences between languages, pause fillers in different languages often sound similar because they tend to be the easiest and most neutral vowel sounds to make (such as the schwa), i.e the sounds that can be pronounced with a relaxed tongue or jaw. Research
Recent linguistic research has suggested that non-pathological disfluencies may contain a variety of meaning; the frequency of "uh" and "um" in English is often reflective of a speakers alertness or emotional state.