Some animals that meet these criteria are sheep, non-human primates, rabbits, spiny mice, and guinea pigs.Transplantation of neural stem cells and umbilical cord stem cells is currently being trialed in neonatal brain injury, but it is not yet known if this therapy is likely to be successful. References
Further reading
Nelson, KB; Lynch, JK (March 2004). "Stroke in newborn infants". Lancet Neurology. 3 (3): 150–8. doi:10.1016/s1474-4422(04)00679-9. PMID 14980530. S2CID 11194017. Nelson, K. B. (29 January 2007). "Perinatal Ischemic Stroke". Stroke. 38 (2): 742–745. doi:10.1161/01.STR.0000247921.97794.5e. PMID 17261729. Rutherford, MA; Ramenghi, LA; Cowan, FM (September 2012). "Neonatal stroke". Archives of Disease in Childhood: Fetal and Neonatal Edition. 97 (5): F377-84. doi:10.1136/fetalneonatal-2010-196451. PMID 22933099. S2CID 32645328. Perinatal Stroke-Classification
Unique Approach to Neonatal Stroke Treatment
This should be considered if patients develop any systemic symptoms
Generalized eruption of cutaneous mastocytosis (adult type) is the most common pattern of mastocytosis presenting to the dermatologist, with the most common lesions being macules, papules, or nodules that are disseminated over most of the body but especially on the upper arms, legs, and trunk
Diffuse cutaneous mastocytosis has diffuse involvement in which the entire integument may be thickened and infiltrated with mast cells to produce a peculiar orange color, giving rise to the term "homme orange. "Cutaneous mastocytosis in children usually presents in the first year after birth and in most cases vanishes during adolescence. Systemic mastocytosis (SM)
Systemic mastocytosis involves the bone marrow in the majority of cases and in some cases other internal organs, usually in addition to involving the skin. Mast cells collect in various tissues and can affect organs where mast cells do not normally inhabit such as the liver, spleen and lymph nodes, and organs which have normal populations but where numbers are increased. In the bowel, it may manifest as mastocytic enterocolitis. However, normal ranges for mast cell counts in the gastrointestinal tract mucosa are not well established in the literature, and depend upon the exact location (e.g. right versus left colon), gender, and patient populations (such as asymptomatic patients versus patients with chronic diarrhea of unknown etiology). Quantitative mast cell stains may yield little diagnostic information, and further research studies are warranted to determine whether "mastocytic enterocolitis" truly represents a distinct entity.There are five types of systemic mastocytosis:
Indolent systemic mastocytosis (ISM).