Inclusion body myositis (IBM) () (sometimes called sporadic inclusion body myositis, sIBM) is the most common inflammatory muscle disease in older adults. The disease is characterized by slowly progressive weakness and wasting of both proximal muscles (located on or close to the torso) and distal muscles (close to hands or feet), most apparent in the finger flexors and knee extensors. IBM is often confused with an entirely different class of diseases, called hereditary inclusion body myopathies (hIBM). The "M" in hIBM is an abbreviation for "myopathy" while the "M" in IBM is for "myositis". In IBM, two processes appear to occur in the muscles in parallel, one autoimmune and the other degenerative. Inflammation is evident from the invasion of muscle fibers by immune cells. Degeneration is characterized by the appearance of holes, deposits of abnormal proteins, and filamentous inclusions in the muscle fibers. sIBM is a rare disease, with a prevalence ranging from 1 to 71 individuals per million.Weakness comes on slowly (over months to years) in an asymmetric manner and progresses steadily, leading to severe weakness and wasting of arm and leg muscles. IBM is more common in men than women. Patients may become unable to perform activities of daily living and most require assistive devices within 5 to 10 years of symptom onset. sIBM does not significantly affect life expectancy, although death related to malnutrition and respiratory failure can occur. The risk of serious injury due to falls is increased. There is no effective treatment for the disease as of 2019.
When mothers actively smoke during pregnancy, their child is at a higher risk of being born with a low birth weight. Smoking can also be a stress management tool used by expecting mothers. There is some support for lower socioeconomic status of the parents being a determinant of low birth weight, but there is conflicting evidence, as socioeconomic status is tied to many other factors. Neonatal care
Most babies admitted to the NICU are born before 37 weeks of pregnancy or have low birth weight which is less than 5.5 pounds (2.5 kg). They could also have a medical condition that requires special care. In the United States nearly half a million babies are born preterm. Because of this, many of these babies also have low birth weights. There are four levels of care in the neonatal care units. Intensive Care, High Dependency Care, Low Dependency, and Transitional Care are the four levels:
Intensive Care: For babies with serious problems. This includes babies born three months early and have extremely low birth weight. High Dependency Care: For babies with less serious problem, but who still may not to be looked after or babies that are recovering from a critical illness. Low Dependency Care: For babies that do not need a continuous supervision. Transitional Care: For babies that still need medical treatment, but are well enough to be called for at their mothers bedside.