The 18th Dynasty Egyptian pharaoh Tutankhamun is believed by some to have had Klippel–Feil syndrome, though others dispute this claim. Contemporary
English cricketer Gladstone Small
"Big" Ed Brown from the TLC series, 90 Day Fiancé. Kansas City Chiefs wide receiver Justyn Ross. References
This article incorporates information in the public domain prepared by the National Institute of Neurological Disorders and Stroke. External links
Klippel–Feil syndrome at Curlie
Amoxapine is also a weak GlyT2 blocker, as well as a weak (Ki = 2.5 μM, EC50 = 0.98 μM) δ-opioid receptor partial agonist.7-Hydroxyamoxapine, a major active metabolite of amoxapine, is a more potent dopamine receptor antagonist and contributes to its neuroleptic efficacy, whereas 8-hydroxyamoxapine is a norepinephrine reuptake inhibitor but a stronger serotonin reuptake inhibitor and helps to balance amoxapines ratio of serotonin to norepinephrine transporter blockade. Pharmacokinetics
Amoxapine is metabolised into two main active metabolites: 7-hydroxyamoxapine and 8-hydroxyamoxapine. Where:
- t1/2 is the elimination half life of the compound. - tmax is the time to peak plasma levels after oral administration of amoxapine. - CSS is the steady state plasma concentration. - protein binding is the extent of plasma protein binding. - Vd is the volume of distribution of the compound. Society and culture
Brand names
Brand names for amoxapine include (where † denotes discontinued brands):
Adisen (KR)
Amolife (IN)
Amoxan (JP)
Asendin† (previously marketed in CA, NZ, US)
Asendis† (previously marketed in IE, UK)
Défanyl (FR)
Demolox (DK†, IN, ES†)
Oxamine (IN)
Oxcap (IN)

See also
Loxapine


== References ==