When "symbols of Cambodian society were equally disrupted, social institutions of every kind…were purged or torn down", cultural violence (defined as when "any aspect of culture such as language, religion, ideology, art, or cosmology is used to legitimize direct or structural violence") is added to the structural violence of forced movement and to the direct violence, such as murder, at the Killing Fields. Vietnam eventually intervened and the genocide officially ended. However, ten million landmines left by opposing guerillas in the 1970s continue to create a violent landscape in Cambodia. Human geography, though coming late to the theorizing table, has tackled violence through many lenses, including anarchist geography, feminist geography, Marxist geography, political geography, and critical geography. However, Adriana Cavarero notes that, "as violence spreads and assumes unheard-of forms, it becomes difficult to name in contemporary language". Cavarero proposes that, in facing such a truth, it is prudent to reconsider violence as "horrorism"; that is, "as though ideally all the…victims, instead of their killers, ought to determine the name". With geography often adding the forgotten spatial aspect to theories of social science, rather than creating them solely within the discipline, it seems that the self-reflexive contemporary geography of today may have an extremely important place in this current (re)imaging of violence, exemplified by Cavarero. Epidemiology
As of 2010, all forms of violence resulted in about 1.34 million deaths up from about 1 million in 1990. Suicide accounts for about 883,000, interpersonal violence for 456,000 and collective violence for 18,000.
Tranexamic acid (TXA) is a medication used to treat or prevent excessive blood loss from major trauma, postpartum bleeding, surgery, tooth removal, nosebleeds, and heavy menstruation. It is also used for hereditary angioedema. It is taken either orally or by injection into a vein. Mechanism of action
Tranexamic acid is a synthetic analog of the amino acid lysine. It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen. This decreases the conversion of plasminogen to plasmin, preventing fibrin degradation and preserving the framework of fibrins matrix structure. Tranexamic acid has roughly eight times the antifibrinolytic activity of an older analogue, ε-aminocaproic acid. Tranexamic acid also directly inhibits the activity of plasmin with weak potency (IC50 = 87 mM), and it can block the active-site of urokinase plasminogen activator (uPA) with high specificity (Ki = 2 mM), one of the highest among all the serine proteases.Side effects are rare. Some include changes in color vision, blood clots, and allergic reactions. Greater caution is recommended in people with kidney disease. Tranexamic acid appears to be safe for use during pregnancy and breastfeeding. Tranexamic acid is an antifibrinolytic medication.Tranexamic acid was first made in 1962 by Japanese researchers Shosuke and Utako Okamoto. It is on the World Health Organizations List of Essential Medicines. Tranexamic acid is available as a generic drug. Medical uses
Tranexamic acid is frequently used following major trauma.