However, there is a slight possibility (around 1%) due to germline mosaicism, a phenomenon in which some sperm cell precursors have the mutation and others dont. Genetic counselling may be offered for this. Epidemiology
The prevalence of the disorder is as yet unknown. As of May 2019, 26 individuals worldwide were known to be affected, with 13 of these reported in literature, mostly from 2010 to 2019. History
Okamoto syndrome was first described in 1997 by Nobuhiko Okamoto et al. from the Department of Medical Genetics at Osaka Womens and Childrens Hospital after observing very similar symptoms and physical features in two unrelated Japanese infants. Both infants had congenital hydronephrosis due to ureteropelvic junction stenosis, low muscle tone, developmental delay and characteristic facial features including an open mouth and low-set ears.Au–Kline syndrome was first described in 2015 by Ping-Yee Billie Au, Antonie D. Kline et al. after mutations in HNRNPK were found in two individuals with similar symptoms at their respective practices in Calgary, Alberta, Canada and Baltimore, Maryland, United States. The practices were united with each other after both submitted the gene as a candidate to the online service GeneMatcher, which matched them together and allowed them to confirm the syndrome.In 2019, Okamoto proposed that Au–Kline syndrome and Okamoto syndrome were synonymous, because a mutation in the HNRNPK gene had been found in a new Okamoto syndrome patient, and the symptoms were virtually identical. See also
CDK13-related disorder
Kabuki syndrome

References
External links
Au–Kline syndrome at the US National Institutes of Health (NIH) Genetics Home Reference
Researchers predict that if this upwards trend continues, the amount of food insecure seniors will increase by 50% by 2025.This age group suffers the most from chronic conditions, including heart disease, diabetes, and respiratory diseases. Eighty percent of this group has a minimum of one chronic condition, and almost 70% have two or more. These illnesses are exacerbated and are more likely to develop under the addition of hunger. A report from 2017 shows that seniors facing this issue are 60% more likely to experience depression than seniors who are not hungry, and 40% are more likely to develop congestive heart failure. The added stress of inconsistent and inadequate feedings make these conditions much more dangerous.Fixed incomes often limit the elderly’s ability to freely purchase food necessities. Medical costs and housing may take priority over quality foods. Limited mobility makes it difficult for these individuals to physically leave their homes, especially in areas lacking public transportation or transportation catering to a disabled body. The COVID-19 pandemic has made things even more difficult, as this group is extremely vulnerable to contracting variants. They are high-risk, and are faced with the threat of this disease, more so than other age groups, when they leave their homes. This continues to limit their food access. The Supplemental Nutrition Assistance Program (SNAP) provides aid to low-income seniors in relation to food security. This is an opportunity for seniors who receive benefits to allocate money in their budgets for other needs, such as medical or housing bills. However, participation is extremely low.