Fludrocortisone, sold under the brand name Florinef, among others, is a corticosteroid used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency. In adrenal insufficiency, it is generally taken together with hydrocortisone. Fludrocortisone is taken by mouth and is most commonly used in its acetate form.Common side effects of fludrocortisone include high blood pressure, swelling, heart failure, and low blood potassium. Other serious side effects can include low immune-system function, cataracts, muscle weakness, and mood changes. Whether use of fludrocortisone during pregnancy is safe for the fetus is unknown. Fludrocortisone is mostly a mineralocorticoid, but it also has glucocorticoid effects.Fludrocortisone was patented in 1953. It is on the World Health Organizations List of Essential Medicines. Medical uses
Fludrocortisone has been used in the treatment of cerebral salt-wasting syndrome. It is used primarily to replace the missing hormone aldosterone in various forms of adrenal insufficiency such as Addisons disease and the classic salt-wasting (21-hydroxylase deficiency) form of congenital adrenal hyperplasia. Due to its effects on increasing Na+ levels, and therefore blood volume, fludrocortisone is the first-line of treatment for orthostatic intolerance and postural orthostatic tachycardia syndrome (POTS). It can be used to treat low blood pressure.Fludrocortisone is also a confirmation test for diagnosing Conns syndrome (aldosterone-producing adrenal adenoma), the fludrocortisone suppression test. Loading the patient with fludrocortisone would suppress serum aldosterone level in a normal patient, whereas the level would remain elevated in a Conns patient. The fludrocortisone suppression test is an alternative to the NaCl challenge (which would use normal saline or salt tablets).
In pediatric medicine, acrocephalosyndactyly is the common presentation of craniosynostosis and syndactyly. When there is also polydactyly the classification is acrocephalopolysyndactyly. Cause
Diagnosis
Classification
It has several different types:

type I – Apert syndrome: 577 
type II – Crouzon syndrome: 577 
type III – Saethre–Chotzen syndrome
type IV – Goodman Syndrome
type V – Pfeiffer syndromeA related term, acrocephalopolysyndactyly, refers to the inclusion of polydactyly to the presentation. It also has multiple types:

type I – Noack syndrome; now classified with Pfeiffer syndrome
type II – Carpenter syndrome
type III – Sakati–Nyhan–Tisdale syndrome
type IV – Goodman syndrome; now classified with Carpenter syndrome
type V – Pfeiffer syndromeIt has been suggested that the distinction between "acrocephalosyndactyly" versus "acrocephalopolysyndactyly" should be abandoned. Treatment
See also
List of skin conditions
Oxycephaly

References
External links

Acrocephalosyndactylia at the US National Library of Medicine Medical Subject Headings (MeSH)