Signs and symptoms
Humans
The course of fasciolosis in humans has 4 main phases:Incubation phase: from the ingestion of metacercariae to the appearance of the first symptoms; time period: few days to 3 months; depends on number of ingested metacercariae and immune status of host
Invasive or acute phase: fluke migration up to the bile ducts. This phase is a result of mechanical destruction of the hepatic tissue and the peritoneum by migrating juvenile flukes causing localized and or generalized toxic and allergic reactions. The major symptoms of this phase are:
Fever: usually the first symptom of the disease; 40–42 °C (104–108 °F)
Abdominal pain
Gastrointestinal disturbances: loss of appetite, flatulence, nausea, diarrhea
Urticaria
Respiratory symptoms (very rare): cough, dyspnoea, chest pain, hemoptysis
Hepatomegaly and splenomegaly
Ascites
Anaemia
Jaundice
Latent phase: This phase can last for months or years. The proportion of asymptomatic subjects in this phase is unknown. They are often discovered during family screening after a patient is diagnosed. Chronic or obstructive phase:This phase may develop months or years after initial infection. Adult flukes in the bile ducts cause inflammation and hyperplasia of the epithelium. The resulting cholangitis and cholecystitis, combined with the large body of the flukes, are sufficient to cause mechanical obstruction of the biliary duct. In this phase, biliary colic, epigastric pain, fatty food intolerance, nausea, jaundice, pruritus, right upper-quadrant abdominal tenderness, etc., are clinical manifestations indistinguishable from cholangitis, cholecystitis and cholelithiasis of other origins. Hepatic enlargement may be associated with an enlarged spleen or ascites.
Amelia may refer to:

Arts, entertainment, and media
Films
Amélia (film), a 2000 Brazilian film directed by Ana Carolina
Amelia (film), a 2009 film based on the life of Amelia Earhart

Literature
Amelia (magazine), a Swedish womens magazine
Amelia (novel), a 1751 sentimental novel by Henry Fielding
Amelia Bedelia, a series of US childrens books
Amelia Jane, a series of books by Enid Blyton
Amelia Rules!, a series of American childrens graphic novels

Music
Amelia (opera), music by Daron Hagen; libretto by Gardner McFall; story by Stephen Wadsworth
"Amelia" (song), a song by Joni Mitchell on her 1976 album Hejira
"Amelia", a song by The Mission, from the album Carved in Sand
"Amelia", a song by the Cocteau Twins on their 1984 album Treasure
"Amelia", a song by Prism on their 1977 album Prism
"Amelia", a 1972 song by Wayne Cochran and The C.C. Riders

People
Amelia (given name), including people so named
Marco Amelia (born 1982), Italian football goalkeeper
Princess Amelia (disambiguation)

Places
United States
Amelia, Louisiana, a census-designated place in St. Mary Parish, Louisiana
Amelia, Nebraska, an unincorporated community in Holt County, Nebraska
Amelia, Ohio, a village in Clermont County, Ohio
Amelia, Washington
Amelia, West Virginia
Amelia City, Florida, a town in Nassau County, Florida
Amelia County, Virginia
Amelia Courthouse, Virginia, a village in Amelia County near Richmond
Amelia Island, the southernmost of the Sea Islands, near Florida

Elsewhere
Amelia, Umbria, a town in Italy
Amelia Cove, Newfoundland and Labrador, Canada, a hamlet in the St. Barbe District, near Griguet

Ships
Amelia (ship)
HMS Amelia, ships of the Royal Navy

Other uses
Amelia (birth defect)
Amelia (typeface)
Tropical Storm Amelia (disambiguation)
Amelia (company), an internet technology company

See also
Aemilia (disambiguation)
Amélie (disambiguation)