In 2006, paroxetine was the fifth-most prescribed antidepressant in the U.S. retail market, with more than 19.7 million prescriptions. In 2007, sales had dropped slightly to 18.1 million but paroxetine remained the fifth-most prescribed antidepressant in the U.S.

Trade names
Trade names include Aropax, Paretin, Brisdelle, Deroxat, Paxil, Pexeva, Paxtine, Paxetin, Paroxat, Paraxyl, Sereupin, Daparox and Seroxat. Research
Several studies have suggested that paroxetine can be used in the treatment of premature ejaculation. In particular, intravaginal ejaculation latency time (IELT) was found to increase with 6- to 13-fold, which was somewhat longer than the delay achieved by the treatment with other SSRIs (fluvoxamine, fluoxetine, sertraline, and citalopram). However, paroxetine taken acutely ("on demand") 3–10 hours before coitus resulted only in a "clinically irrelevant and sexually unsatisfactory" 1.5-fold delay of ejaculation and was inferior to clomipramine, which induced a fourfold delay.There is also evidence that paroxetine may be effective in the treatment of compulsive gambling and hot flashes.Benefits of paroxetine prescription for diabetic neuropathy or chronic tension headache are uncertain. Although the evidence is conflicting, paroxetine may be effective for the treatment of dysthymia, a chronic disorder involving depressive symptoms for most days of the year.There is evidence to support that paroxetine selectively binds to and inhibits G protein-coupled receptor kinase 2 (GRK2) in mice with heart failure.
Since GRK2 regulates the activity of the beta adrenergic receptor, which becomes desensitized in cases of heart failure, paroxetine (or a paroxetine derivative) could be used as a heart failure treatment in the future.Paroxetine has been identified as a potential disease-modifying osteoarthritis drug. Other organisms
Paroxetine is a common finding in waste water. It is highly toxic to the alga Pseudokirchneriella subcapitata (syn. Raphidocelis subcapitata).It also is toxic to the soil nematode Caenorhabditis elegans.Alberca et al., 2016 finds paroxetine acts as a trypanocide against T. cruzi. See also
List of medical ethics cases

References
External links

"Paroxetine". Drug Information Portal. U.S. National Library of Medicine. Detailed Paroxetine Consumer Information: Uses, Precautions, Side Effects from medlibrary.org