Zirabev was approved for medical use in the United States in June 2019, and in Australia in November 2019.In June 2020, Mvasi was approved for medical use in Australia.In August 2020, Aybintio was approved for use in the European Union.In September 2020, Equidacent was approved for use in the European Union.On 28 January 2021, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Alymsys, intended for the treatment of carcinoma of the colon or rectum, breast cancer, non-small cell lung cancer, renal cell cancer, epithelial ovarian, fallopian tube or primary peritoneal cancer, and carcinoma of the cervix. Alymsys was approved for medical use in the European Union in March 2021.In January 2021, Onbevzi was approved for medical use in the European Union.In June 2019, and June 2021, Zirabev was approved for medical use in Canada.Abevmy was approved for medical use in the European Union in April 2021, and in Australia in September 2021.In September 2021, Bambevi was approved for medical use in Canada.Bevacip and Bevaciptin were approved for medical use in Australia in November 2021.In November 2021, Abevmy and Aybintio were approved for medical use in Canada.In April 2022, Alymsys was approved for medical use in the United States.In September 2022, Vegzelma was approved for medical use in the United States.
The lesions are located on the head, neck, tail, and perineum. The typical lesion is a round, whitish crust. Multiple lesions may coalesce in "map-like" appearance. Clinical dermatophytosis is also diagnosed in sheep, dogs, cats, and horses. Causative agents, besides Trichophyton verrucosum, are T. mentagrophytes, T. equinum, Microsporum gypseum, M. canis, and M. nanum.Dermatophytosis may also be present in the holotype of the Cretaceous eutriconodont mammal Spinolestes, suggesting a Mesozoic origin for this disease. Diagnosis
Ringworm in pets may often be asymptomatic, resulting in a carrier condition which infects other pets. In some cases, the disease only appears when the animal develops an immunodeficiency condition. Circular bare patches on the skin suggest the diagnosis, but no lesion is truly specific to the fungus. Similar patches may result from allergies, sarcoptic mange, and other conditions. Three species of fungi cause 95% of dermatophytosis in pets: these are Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes. Veterinarians have several tests to identify ringworm infection and identify the fungal species that cause it:
Woods test: This is an ultraviolet light with a magnifying lens. Only 50% of M. canis will show up as an apple-green fluorescence on hair shafts, under the UV light. The other fungi do not show. The fluorescent material is not the fungus itself (which does not fluoresce), but rather an excretory product of the fungus which sticks to hairs. Infected skin does not fluoresce. Microscopic test: The veterinarian takes hairs from around the infected area and places them in a staining solution to view under the microscope.