Its adverse effects include intoxication, hypoglycemia in children, and possible liver toxicity. People receiving ethanol therapy also require frequent blood ethanol concentration measurements and dosage adjustments to maintain a therapeutic ethanol concentration. People therefore must be monitored in an intensive care unit. Alternatively, the adverse side effects of fomepizole are minimal and the approved dosing regimen maintains therapeutic concentrations without the need to monitor blood concentrations of the drug. The disadvantage of fomepizole is that it is expensive. Costing US$1,000 per gram, an average course used in an adult poisoning would cost approximately $3,500 to $4,000. Despite the cost, fomepizole is gradually replacing ethanol as the antidote of choice in ethylene glycol poisoning.Adjunct agents including thiamine and pyridoxine are often given, because they may help prevent the formation of oxalic acid. The use of these agents is based on theoretical observations and there is limited evidence to support their use in treatment; they may be of particular benefit in people who could be deficient in these vitamins such as those who are malnourished or alcoholic. Hemodialysis
In addition to antidotes, an important treatment for poisoning is the use of hemodialysis. Hemodialysis is used to enhance the removal of unmetabolized ethylene glycol, as well as its metabolites from the body. It has been shown to be highly effective in the removal of ethylene glycol and its metabolites from the blood. Hemodialysis also has the added benefit of correcting other metabolic derangements or supporting deteriorating kidney function.
1985 diethylene glycol wine scandal
Elixir sulfanilamide, a banned medicine that caused mass poisoning because it used ethylene glycol as a solvent
Methanol poisoning

References
External links

"Antifreeze Poisoning in Dogs & Cats (Ethylene Glycol Poisoning)" – Pet Poison Helpline
"Antifreeze Poisoning" – Washington State University, College of Veterinary Medicine information sheet
"Overview of Ethylene Glycol Toxicity" – Merck Veterinary Manual information.