CE is advantageous over PAGE in that molecular weight measurements like mass spectrometry can be used with analytes, whereas PAGE requires the use of Southern blot to allow comparison to a sequencing ladder. For repeat lengths within the range where interruptions are relevant, assays like CE and PAGE will not determine if the strain is pathogenic and additional testing will be required. Clinical
No formal diagnostic criteria exist for most SCAs, and genetic testing is the only certain diagnostic method, but clinical examination of signs and symptoms may be vital to distinguishing SCAs from non-genetic ataxias, and from other types of genetic ataxias. Clinical examination can also help distinguish between SCA types to some extent, so genetic tests for certain types can be prioritized over others. Diagnosis of SCAs often begins with the detection of symptoms that suggest a cerebellar disorder, like progressive ataxia or dysarthria, or with recognition of similar symptoms to a case identified in the individuals family history, especially in first or second degree relatives. Many laboratory studies can be used to further narrow the potential cause of ataxia; imaging of brain and spinal cord and various electrophysiology exams may be useful for identifying disease phenotypes and blood and urine studies may rule out acquired causes. : 4 When evaluating ataxic disorders and their treatments, there are numerous tests that a neurologist may perform. Tests may be evaluated individually or follow a scale for evaluating the ataxia.
Lichen striatus  is a rare skin condition that is seen primarily in children, most frequently appearing ages 5–15. : 226–27  It consists of a self-limiting eruption of small, scaly papules. Symptoms
Lichen striatus impacts the skin and nails. It is seen as an unbroken or disrupted, linear band consisting of small tan, pink or flesh colored papules. The papules could be smooth, flat topped or scaly. The band of lichen striatus varies from a few millimeters to 1-- 2 cm wide and extends from a few centimeters to the complete length of the extremity. By and large, the papules are unilateral and single on an extremity along the lines of Blaschko. Itching is an accompanying function of the disorder. Diagnosis
Diagnosis is based on observing the appearance of the lesions. Management
It is self-limiting condition
1.reassurance
2.steroid cream for local application
3.moisturiser lotion

See also
Lichen planus
List of cutaneous conditions

References
External links

New England Journal of Medicine - Images of the Week