The carbon 10 functional group change causes docetaxel to be more water-soluble than paclitaxel. Formulations and compositions
Docetaxel is a white powder and is the active ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80. The solution is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL. 20 mg Taxotere is distributed in a blister carton containing one single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL sterile pyrogen-free anhydrous polysorbate 80, and a single dose Taxotere solvent vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose for administration. 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and solvent vials are combined to give a solution of 10 mg/mL and the required dose is drawn from this solution. Vials have an overfill to compensate for liquid loss during preparation, foaming, adhesion to vial walls and the dead volume. 20 mg vials may be stored for 24 months below 25 °C away from light and 80 mg vials for 26 months in the same conditions.Recently Sanofi has got approval for one-vial formulation. With this one-vial formulation, the preparation of the infusion solution is simplified by eliminating the first dilution step. The two-vial and one-vial formulations contain the same drug substance, docetaxel trihydrate, and the same excipients (ethanol, polysorbate 80 and citric acid).
Middle cerebral artery lesions mostly affect the dominant hemisphere i.e. the left cerebral hemisphere. Signs and Symptoms
Hemiparesis or hemiplegia of the lower half of the contralateral face
Hemiparesis or hemiplegia of the contralateral upper and lower extremities*
Sensory loss of the contralateral face, arm and leg*
Ataxia of contralateral extremities*
Speech impairments/aphasia: Brocas area, Wernickes or Global aphasia as a result of a dominant hemisphere lesion (usually the left brain)
Perceptual deficits: hemispatial neglect, anosognosia, apraxia, and spatial disorganization as a result of a non-dominant hemisphere lesion (usually the right brain)
Visual disorders: déviation conjuguée, a gaze preference towards the side of the lesion; contralateral homonymous hemianopsiaNote: *faciobrachial deficits greater than that of the lower limb

Diagnosis
Diagnosis can be confirmed by CT Scan or MRI for advanced investigations. References


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