Heat tolerance
Cats are able to tolerate quite high temperatures: Humans generally start to feel uncomfortable when their skin temperature passes about 38 °C (100 °F), but cats show no discomfort until their skin reaches around 52 °C (126 °F),: 46  and can tolerate temperatures of up to 56 °C (133 °F) if they have access to water. Temperature regulation
Cats conserve heat by reducing the flow of blood to their skin and lose heat by evaporation through their mouths. Cats have minimal ability to sweat, with glands located primarily in their paw pads, and pant for heat relief only at very high temperatures (but may also pant when stressed). A cats body temperature does not vary throughout the day; this is part of cats general lack of circadian rhythms and may reflect their tendency to be active both during the day and at night. : 1

Water conservation
Cats feces are comparatively dry and their urine is highly concentrated, both of which are adaptations to allow cats to retain as much water as possible. Their kidneys are so efficient, they can survive on a diet consisting only of meat, with no additional water. They can tolerate high levels of salt only in combination with freshwater to prevent dehydration. Ability to swim
While domestic cats are able to swim, they are generally reluctant to enter water as it quickly leads to exhaustion.
Adverse effects
The medication has two FDA "black box" warnings: One raises concerns that use before or during pregnancy by either sex may result in birth defects in the baby, and the other is regarding the risk of red blood cell breakdown.Ribavirin should not be given with zidovudine because of the increased risk of anemia; concurrent use with didanosine should likewise be avoided because of an increased risk of mitochondrial toxicity. Mechanisms of action
It is a guanosine (ribonucleic) analog used to stop viral RNA synthesis and viral mRNA capping, thus, it is a nucleoside inhibitor. Ribavirin is a prodrug, which when metabolized resembles purine RNA nucleotides. In this form, it interferes with RNA metabolism required for viral replication. Over five direct and indirect mechanisms have been proposed for its mechanism of action. The enzyme inosine triphosphate pyrophosphatase (ITPase) dephosphorylates ribavirin triphosphate in vitro to ribavirin monophosphate, and ITPase reduced enzymatic activity present in 30% of humans potentiates mutagenesis in hepatitis C virus. RNA viruses
Ribavirins amide group can make the native nucleoside drug resemble adenosine or guanosine, depending on its rotation. For this reason, when ribavirin is incorporated into RNA, as a base analog of either adenine or guanine, it pairs equally well with either uracil or cytosine, inducing mutations in RNA-dependent replication in RNA viruses. Such hypermutation can be lethal to RNA viruses.