The Sauk or Sac are a group of Native Americans of the Eastern Woodlands culture group, who lived primarily in the region of what is now Green Bay, Wisconsin, when first encountered by the French in 1667. Their autonym is oθaakiiwaki, and their exonym is Ozaagii(-wag) in Ojibwe. The latter name was transliterated into French and English by colonists of those cultures. Today they have three federally recognized tribes, together with the Meskwaki (Fox), located in Iowa, Oklahoma and Kansas. History
Early history
The Sauk, an Algonquian languages people, are believed to have developed as a people along the St. Lawrence River, which is now northern New York. The precise time is unknown, but around the time of the year 1600, they were driven from the area of the St. Lawrence river. Some historians believe that the Sauk migrated to what is now eastern Michigan, where they settled around Saginaw Bay (Ojibwe: Zaagiinaad-wiikwed – "Of the Outlet Bay"). For many years, the Sauk are believed to have prospered in the fertile valley of Saginaw thereafter. They had been driven west by pressure from other tribes, especially the powerful Iroquois League or Haudenosaunee, which sought control over hunting grounds in the area. The neighboring Anishanabeg Ojibwe (Sauk name: Ochipwêwa) and Odawa peoples referred to them by the exonym Ozaagii(-wag), meaning "those at the outlet". French colonists transliterated that as Sac and the English as "Sauk".
Pseudoxanthoma elasticum (PXE) is a genetic disease that causes mineralization of elastic fibers in some tissues. The most common problems arise in the skin and eyes, and later in blood vessels in the form of premature atherosclerosis. PXE is caused by autosomal recessive mutations in the ABCC6 gene on the short arm of chromosome 16 (16p13.1). Signs and symptoms
Usually, pseudoxanthoma elasticum affects the skin first, often in childhood or early adolescence. Small, yellowish papular lesions form and cutaneous laxity mainly affect the neck, axillae (armpits), groin, and flexural creases (the inside parts of the elbows and knees). Skin may become lax and redundant. Many individuals have "oblique mental creases" (horizontal grooves of the chin)PXE first affects the retina through a dimpling of the Bruch membrane (a thin membrane separating the blood vessel-rich layer from the pigmented layer of the retina), that is only visible during ophthalmologic examinations. This is called peau dorange (a French term meaning "skin of the orange"). Eventually the mineralization of the elastic fibers in the Bruch membrane create cracks called angioid streaks that radiate out from the optic nerve. Angioid streaks themselves do not cause distortion of vision, even if they cross into the foveal area. This symptom is present in almost all PXE patients and is usually noticed a few years after the onset of cutaneous lesions. These cracks may allow small blood vessels that were originally held back by Bruchs membrane to penetrate the retina.