Treatment
The primary goal of surgical intervention is to allow normal cranial vault development to occur. This can be achieved by excision of the prematurely fused suture and correction of the associated skull deformities. If the synostosis goes uncorrected, the deformity will progressively worsen not only threatening the aesthetic aspect, but also the functional aspect. This is especially prevalent with asymmetric conditions, such as unilateral coronal synostosis, with compromised function of the eyes and the jaw. In addition, signs of compromised neurodevelopment have been seen amongst all the synostoses, although this may also be caused by primary maldevelopment of the brain and can thus not be prevented by surgical intervention.There are a few basic elements involved in surgical intervention which is aimed at normalization of the cranial vault:

Surgery for craniosynostosis is often associated with significant perioperative hemorrhage so multiple strategies are often used to minimize blood loss. One such method involves the injection of vasoconstrictive agents (i.e. epinephrine) seven to ten minutes before scalp incision. Additionally, the initiation of surgery should be delayed until blood products are physically present in the operating room. Another general agreement is the avoidance of the use of titanium plates in the fixation of the skull. One potential complication following this procedure involves the gradual movement of the titanium plates towards the brain, induced by resorption of the innermost bone layer of the skull with deposition of new bone on the outermost layer, thereby integrating the titanium plates.
The goal of treatment is to position this bar together with the frontal bone in a plane three millimetres further forwards than the vertical plane of the cornea. A two-dimensional sagittal image is used to pre-operatively determine the extent of movement, which can vary between seven and fifteen millimetres depending on the severity of the deformity.The orbital asymmetry exists typically of a narrower and taller orbit at the ipsilateral side of the head. The contralateral orbit, however, is wider than usual. Symmetry is restored by extracting a small piece of bone from the supraorbital bar at the contralateral side, thereby reducing the width. This bone fragment is then introduced into the supraorbital bar on the ipsilateral side, thereby increasing width. The height of the orbit is altered at the ipsilateral side only, by extracting a piece of bone. Any correction of the nasal tip, which points towards the contralateral side, will not be performed during childhood. Unilateral lambdoid synostosis/posterior plagiocephaly
An excision of the flattened occipital bone with release of the fused suture tends to correct the cranial vault deformity. Bilateral coronal synostosis/brachycephaly
The treatment of bilateral coronal synostosis shows a high degree of overlap with treatment of unilateral coronal synostosis; in both surgical interventions is the forward advancement of the supraorbital rim together with the frontal bones is an important part of the procedure. Again, the plane three millimetres further forwards than the vertical plane of the [cornea] is the appropriate position to place the bone.