In 1879, Vassili von Anrep of the University of Würzburg conducted an experiment in which he applied cocaine to one side of a frog’s limbs before attempting an invasive medical procedure. Cocaine proved to be extremely effective as both an anesthetic and pain reducer.In World War II, soldiers were medicated using a type of stimulant called amphetamines to keep both pilots and soldiers alert, full of energy, and ready to fight. Amphetamines were given in pill form to American soldiers, as well as to Japanese and German military members. It is estimated that German soldiers ingested roughly 35 million doses of Pervitin® through the course of the war. Pervitin® is a brand-name for methamphetamine, a drug that belongs to the stimulant class of drugs. The use of methamphetamine was an attempt by the Nazi leadership to create "super soldiers" who felt no pain and operated with extreme energy and unwavering confidence. The United States, for comparison, had dispensed roughly 200 million Benzedrine® tablets. A mixture of amphetamine salts, these pills were favored for their ability to increase wakefulness and energy levels while simultaneously suppressing appetite.The United States, around the year 1960, saw large increases in amphetamines sold as diet pills, with pharmaceutical companies recognizing the appetite-suppressing and energy-boosting effects stimulants could provide. It was estimated that worldwide sales of diet pills containing stimulants rocketed to over 10 billion tablets sold and that between 6% and 8% of the U.S. population were prescribed these types of medications to aid in weight loss.
In breastfeeding, lactation failure may refer to:

Primary lactation failure, a cause of low milk supply in breastfeeding mothers
Cessation of breastfeeding before the mother had planned to stop, usually as a result of breastfeeding difficulties
Low milk supply in generalLactation failure can result in neonatal jaundice. References

Lawrence, Ruth A. (1986). "Maternal Factors in Lactation Failure". Human Lactation 2. Boston, MA: Springer US. pp. 283–291. doi:10.1007/978-1-4615-7207-7_25. ISBN 978-1-4615-7209-1. Lawrence, Ruth (2016). Breastfeeding : a guide for the medical profession, 8th edition. Philadelphia, PA: Elsevier. p. 836. ISBN 978-0-323-35776-0. == External links ==