Tandem genomic duplication is the only proposed mechanism with supporting in vivo experimental evidence: a short intragenic tandem duplication can insert a novel intron into a protein-coding gene, leaving the corresponding peptide sequence unchanged. This mechanism also has extensive indirect evidence lending support to the idea that tandem genomic duplication is a prevalent mechanism for intron gain. The testing of other proposed mechanisms in vivo, particularly intron gain during DSBR, intron transfer, and intronization, is possible, although these mechanisms must be demonstrated in vivo to solidify them as actual mechanisms of intron gain. Further genomic analyses, especially when executed at the population level, may then quantify the relative contribution of each mechanism, possibly identifying species-specific biases that may shed light on varied rates of intron gain amongst different species. See also
Structure:

Exon
mRNA
Eukaryotic chromosome fine structure
Small t intronSplicing:

Alternative splicing
Exitron
Minor spliceosome
OutronFunction

MicroRNAOthers:

Exon shuffling
Intein
Interrupted gene
Noncoding DNA
Noncoding RNA
Selfish DNA
Twintron
Exon-intron database

References
External links

A search engine for exon/intron sequences defined by NCBI
Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter Molecular Biology of the Cell, 2007, ISBN 978-0-8153-4105-5. Fourth edition is available online through the NCBI Bookshelf: link
Jeremy M Berg, John L Tymoczko, and Lubert Stryer, Biochemistry 5th edition, 2002, W H Freeman. Available online through the NCBI Bookshelf: link
Intron finding tool for plant genomic sequences
Exon-intron graphic maker
Lymphedema praecox is a condition characterized by swelling of the soft tissues in which an excessive amount of lymph has accumulated, and generally develops in females between the ages of nine and twenty-five. This is the most common form of primary lymphedema, accounting for about 80% of the patients. : 848

See also
Lymphedema
Lymphedema-distichiasis syndrome
Aagenaes syndrome
List of cutaneous conditions

References


== External links ==