The AUC and Cmax of calaspargase pegol-mknl were compared to pegaspargase.Calaspargase pegol-mknl received FDA orphan drug designation. The approval was granted to Servier Pharmaceuticals LLC. References
External links
"Calaspargase pegol". Drug Information Portal. U.S. National Library of Medicine. "Calaspargase pegol-mknl". National Cancer Institute. 25 January 2019. "Calaspargase pegol-mknl". NCI Drug Dictionary. National Cancer Institute.
Tay syndrome should not be confused with the Tay–Sachs disease. : 485   It is an autosomal recessive congenital disease. : 501  In some cases, it can be diagnosed prenatally. IBIDS syndrome is nonphotosensitive. Cause
The photosensitive form is referred to as PIBIDS, and is associated with ERCC2 and ERCC3. Photosensitive forms
All photosensitive TTD syndromes have defects in the nucleotide excision repair (NER) pathway, which is a vital DNA repair system that removes many kinds of DNA lesions. This defect is not present in the nonphotosensitive TTDs. These type of defects can result in other rare autosomal recessive diseases like xeroderma pigmentosum and Cockayne syndrome. DNA repair
Currently, mutations in four genes are recognized as causing the TTD phenotype, namely TTDN1, XPB, XPD and TTDA. Individuals with defects in XPB, XPD and TTDA are photosensitive, whereas those with a defect in TTDN1 are not. The three genes, XPB, XPD and TTDA, encode protein components of the multi-subunit transcription/repair factor IIH (TFIIH). This complex factor is an important decision maker in NER that opens the DNA double helix after damage is initially recognized. NER is a multi-step pathway that removes a variety of different DNA damages that alter normal base pairing, including both UV-induced damages and bulky chemical adducts. Features of premature aging often occur in individuals with mutational defects in genes specifying protein components of the NER pathway, including those with TTD (see DNA damage theory of aging). Diagnosis
Treatment
See also
Skin lesion
List of cutaneous conditions

References
External links
NIH document on Tay syndrome