One form has been associated with DXYS154.Secondary chronic intestinal pseudo-obstruction can occur as a consequence of a number of other conditions including:

Hirschsprungs disease - the absence of colonic nerve cells
Chagas disease - a chronic parasitic infection of the colon leading to loss of nerve endings
Kawasaki disease - a rare presentation for this particular autoimmune disorder of the vasculature
Parkinsons disease - related to the neurodegeneration of gastrointestinal tract
Autoimmune conditions - conditions including systemic lupus erythematosus and scleroderma lead to collagen vascular deposition and gastrointestinal motility disruption
Mitochondrial disease - IPO is a known presentation for mitochondrial disease
Endocrine disorders
Certain medications.The term may be used synonymously with enteric neuropathy if a neurological cause is suspected. Diagnosis
The symptoms of IPO are nonspecific. It is not unusual for patients to present repeatedly and to undergo numerous tests. Mechanical causes of intestinal obstruction must be excluded to reach a diagnosis of pseudo-obstruction. Attempts must also be made to determine whether the IPO is the result of a primary or secondary condition. A diagnostic work-up may include:
Gastric motility studies
Imaging studies:
 X-rays - may show intestinal air fluid levels (seen with true mechanical intestinal obstruction)
CT scans
Barium enema
Blood tests
Upper and lower endoscopies
Manometry - used to measure pressure of esophagus and stomach

Treatment
Treatment for IPO (acute or chronic) is aimed at removing the disease process and/or managing the complications present. Focus is placed on management of pain, gastrointestinal symptoms, nutritional deficiencies, fluid status, infection control, and improving quality of life. When CIPO is secondary to another disease, treatment is addressed towards the underlying condition.
Bacterial overgrowth of the small intestine can occur in chronic cases - presenting as malabsorption, diarrhea, and nutrient deficiencies - which may require the use of antibiotics. Presentation
Clinical features of IPO can include abdominal pain, nausea, abdominal distension, vomiting, dysphagia, and constipation. Symptoms depend on the portion of the gastrointestinal tract involved and the duration of symptoms. Symptoms may occur intermittently and over a prolonged period of time. It is not unusual for patients to present several times owing to the nonspecific nature of the symptoms. Conditions and onset will vary if the disease is primary vs secondary and the underlying disease (if a secondary manifestation) and its management. Symptoms indicative of advanced disease and possible intestinal failure include diarrhea, loss of appetite, sepsis, bloating, fatigue, signs of low volume status, and malabsorption including nutritional deficiencies and foul-smelling stools. Causes
In primary CIPO (the majority of chronic cases) the condition results from disruption of the intestines ability to move food. These can be broadly classified as myopathic (affecting the smooth muscle), mesenchymopathic (affecting the interstitial cells of Cajal), or neuropathic (of the nervous system) of the gastrointestinal tract.In some cases there appears to be a genetic association.