Sumatriptan, sold commonly under  brand names Imitrex and Treximet among others, is a medication used to treat migraine headaches and cluster headaches. It is taken orally, intranasally, or by subcutaneous injection. Therapeutic effects generally occur within three hours.Its primary effect as a serotonin 5-HT1B/1D receptor agonist can create common side effects such as chest pressure, fatigue, vomiting, tingling, and vertigo. Serious side effects may include serotonin syndrome, heart attacks, strokes, and seizures. With excessive medication overuse headaches may occur. It is unclear if use during pregnancy or breastfeeding is safe. The mechanism of action not entirely clear. It is in the triptan class of medications.Sumatriptan was patented in 1982 and approved for medical use in 1991. It is on the World Health Organizations List of Essential Medicines. It is available as a generic medication. In 2019, it was the 98th most commonly prescribed medication in the United States, with more than seven million prescriptions. It is also available as the combination product sumatriptan/naproxen. Medical uses
Sumatriptan is effective for ending or relieving the intensity of migraine and cluster headaches. It is most effective when taken early after the start of the pain. Injected sumatriptan is more effective than other formulations.Oral sumatriptan can be used also in the treatment of post-dural puncture headache. Adverse effects
Overdose of sumatriptan can cause sulfhemoglobinemia, a rare condition in which the blood changes from red to green, due to the integration of sulfur into the hemoglobin molecule. If sumatriptan is discontinued, the condition reverses within a few weeks.
Glomeruloid hemangioma is a distinctive vascular tumor first described in 1990 when found to be associated with POEMS syndrome and Castleman disease. : 595

See also
List of cutaneous conditions


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