Syringomas are benign eccrine sweat duct tumors, typically found clustered on eyelids, although they may also be found in the armpits, abdomen, chest, neck, scalp, or groin area, including genitals, in a symmetric pattern. : 663   They are skin-colored or yellowish firm, rounded bumps, 1–3 mm in diameter, and may be confused with xanthoma, milia, hidrocystoma, trichoepithelioma, and xanthelasma. They are more common in women and are most commonly found in middle-aged Asian women. While they can present at any time in life, they typically present during adolescence. They are usually not associated with any other symptoms, although can sometimes cause itchiness or irritation. Types
The eruptive form typically presents on the anterior chest, abdomen, neck, and arms. It presents in successive crops with periods of relief in between times of active rash. The milia-like  type of syringoma is typically smaller lesions that have a milky white center that can look like milia. The plaque type is more commonly associated with itchiness and chronic scratching that leads to epidermal thickening similar to lichen planus. The familial form, in some cases of syringoma, exhibits a familial pattern in an autosomal-dominant pattern of inheritance. Chromosome 16q22 has been shown to be involved in the genetic links of syringoma. Presentation
Associated syndromes
Syringomas can be found in association with other symptoms as part of a syndrome.
Diagnosis
Syringomas can often be diagnosed clinically based on presentation, distribution patterns over the body, lack of associated symptoms, and family history. A definitive diagnosis requires a skin biopsy to allow the tissue to be examined under a microscope. Histologically, syringomas have a characteristic comma-shaped ("tadpole") tail of dilated, cystic eccrine ducts. Treatment
The goal of treatment is to improve the appearance of lesions, since they are otherwise not serious and typically do not cause symptoms. Many treatment methods have been attempted, but complete removal is uncommon. No single treatment method has been shown to work consistently. Both medical and surgical treatments have been studied, each with variable success. Common destructive treatment methods include carbon dioxide lasers, dermabrasion, surgical excision, electrocoagulation, and chemical peels. Many of these methods are very time-consuming and require multiple treatment sessions. Carbon dioxide lasers are the most commonly practiced method; they can cause thermal damage, though, leading to scarring in the area. Medical therapies include topical atropine, topical retinoids, and oral tranilast. The most common adverse effects include redness, skin discoloration, and pain. Other side effects include blistering and scarring. See also
Acrospiroma
List of cutaneous conditions
List of cutaneous neoplasms associated with systemic syndromes

References
External links
eMedicine entry on syringomas
DermNet NZ