Notable cases
Tony Bland – first patient in English legal history to be allowed to die
Paul Brophy – first American to die after court-authorization
Sunny von Bülow – lived almost 28 years in a persistent vegetative state until her death
Gustavo Cerati – Argentine singer-songwriter, composer and producer who died after four years in a coma
Prichard Colón – Puerto Rican former professional boxer and gold medal winner who spent years in a vegetative state after a bout
Nancy Cruzan – American woman involved in a landmark United States Supreme Court case
Gary Dockery – American police officer who entered, emerged and later reentered a persistent vegetative state
Eluana Englaro – Italian woman from Lecco whose life was ended after a legal case after spending 17 years in a vegetative state
Elaine Esposito – American woman who was a previous record holder for having spent 37 years in a coma
Lia Lee – Hmong person who spent 26 years in a vegetative state and was the subject of a 1997 book by Anne Fadiman
Martin Pistorius South African man who is a rare example of a survivor as his state progressed to minimally conscious after 3 years, locked in syndrome after another 4 more years, and fully came out of a coma after another 5 years. He is now a web designer, developer, and author. In 2011, he wrote a book called Ghost Boy, in which he describes his many years of being comatose.
In recent years, a number of studies have demonstrated an important role for functional neuroimaging in the identification of residual cognitive function in persistent vegetative state; this technology is providing new insights into cerebral activity in patients with severe brain damage. Such studies, when successful, may be particularly useful where there is concern about the accuracy of the diagnosis and the possibility that residual cognitive function has remained undetected. Diagnostic experiments
Researchers have begun to use functional neuroimaging studies to study implicit cognitive processing in patients with a clinical diagnosis of persistent vegetative state. Activations in response to sensory stimuli with positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and electrophysiological methods can provide information on the presence, degree, and location of any residual brain function. However, use of these techniques in people with severe brain damage is methodologically, clinically, and theoretically complex and needs careful quantitative analysis and interpretation. For example, PET studies have shown the identification of residual cognitive function in persistent vegetative state. That is, an external stimulation, such as a painful stimulus, still activates "primary" sensory cortices in these patients but these areas are functionally disconnected from "higher order" associative areas needed for awareness. These results show that parts of the cortex are indeed still functioning in "vegetative" patients.In addition, other PET studies have revealed preserved and consistent responses in predicted regions of auditory cortex in response to intelligible speech stimuli.