Formal diagnostic criteria and definition of the disease was established in 2016, which will allow for better understanding and the ability to appropriately track and research CD. In 2017, international consensus diagnostic criteria for idiopathic multicentric Castleman disease (iMCD) were established for the first time. In 2018, the first treatment guidelines for iMCD were established. In 2020 the first evidence based diagnostic criteria and treatment guidelines were established for unicentric Castleman disease. World Castleman Disease Day was established in 2018 and is held every year on July 23. This date was chosen for Benjamin Castlemans initial case series describing Castleman disease, which was published in July 1956, and the diagnostic criteria for idiopathic multicentric Castleman disease, which were published in the journal Blood on March 23, 2017. Castleman Disease Collaborative Network
The Castleman Disease Collaborative Network (CDCN) was founded in 2012 and is the largest organization focused on Castleman disease. It is a global initiative dedicated to research and treatment for Castleman disease (CD) and to improve survival for all patients with CD. The CDCN works to achieve this by facilitating collaboration among the global research community, mobilizing resources, strategically investing in high-impact research, and supporting patients and their loved ones. References
Further reading
Fajgenbaum, David (2019). Chasing My Cure: A Doctors Race to Turn Hope into Action; a Memoir. New York: Ballantine Books. ISBN 9781524799618. OCLC 1144129598. Book by the founder of the Castleman Disease Collaborative Network.
Acetohydroxamic acid (also known as AHA or by the trade name Lithostat) is a drug that is a potent and irreversible enzyme inhibitor of the urease enzyme in various bacteria and plants; it is usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by urease; it thus disrupts the bacterias metabolism through competitive inhibition. Orphan drug
In 1983 the US Food and Drug Administration approved acetohydroxamic acid (AHA) as an orphan drug for "prevention of so-called struvite stones" under the newly enacted Orphan Drug Act of 1983. AHA cannot be patented because it is a standard chemical compound. See also
Salicylhydroxamic acid


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