It can be tried for depression as a second-line therapy, after the failure of other treatments. For treatment-resistant adolescent depression or for cancer-related depression amitriptyline is no better than placebo. It is sometimes used for the treatment of depression in Parkinsons disease, but supporting evidence for that is lacking. Pain
Amitriptyline alleviates painful diabetic neuropathy. It is recommended by a variety of guidelines as a first or second line treatment. It is as effective for this indication as gabapentin or pregabalin but less well tolerated.Low doses of amitriptyline moderately improve sleep disturbances and reduce pain and fatigue associated with fibromyalgia. It is recommended for fibromyalgia accompanied by depression by Association of the Scientific Medical Societies in Germany and as a second-line option for fibromyalgia, with exercise being the first line option, by European League Against Rheumatism. Combinations of amitriptyline and fluoxetine or melatonin may reduce fibromyalgia pain better than either medication alone.There is some (low-quality) evidence that amitriptyline may reduce pain in cancer patients. It is recommended only as a second line therapy for non-chemotherapy-induced neuropathic or mixed neuropathic pain, if opioids did not provide the desired effect.Moderate evidence exists in favor of amitriptyline use for atypical facial pain. Amitriptyline is ineffective for HIV-associated neuropathy. Headache
Amitriptyline is probably effective for the prevention of periodic migraine in adults. Amitriptyline is similar in efficacy to venlafaxine and topiramate but carries a higher burden of adverse effects than topiramate. For many patients, even very small doses of amitriptyline are helpful, which may allow for minimization of side effects.
Portia may refer to:

Biology
Portia (spider), a genus of jumping spiders
Anaea troglodyta or Portia, a brush-footed butterfly
Portia tree, a plant native to Polynesia
Ctt. Portia, an orchid Cattlianthe

Medication
A form of birth control made of ethinylestradiol/levonorgestrel

Other uses
Portia (moon), a moon of Uranus
Portia Club, a womens club in Payette, Idaho/USA
Portia, Missouri, a community in the United States
PORTIA portfolio-management software from Thomson Financial
HMS Lennox (1914) or HMS Portia, a Laforey-class destroyer launched in 1914

People with the given name
Portia Arthur (born 1990), Ghanaian author, writer and reporter
Porcia Catonis, the wife of Roman senator Marcus Junius Brutus (fictionalized as  a character in William Shakespeares play Julius Caesar as "Portia")
Portia Dawson, American actress
Portia de Rossi or Portia DeGeneres, Australian-born actress
Portia Doubleday, American actress
Portia Geach (1873–1959), Australian artist and feminist
Portia Holman (1903–1983), Australian child psychiatrist
Portia Mansfield (1887–1979), American dance educator and choreographer
Portia Simpson-Miller, political leader of Jamaicas Peoples National Party and Prime Minister of Jamaica
Portia White, Canadian singer
Portia Zvavahera (born 1985), Zimbabwean painter
Portia, pen name of Abigail Adams (1744-1818)
Portia, pen name of Grizelda Elizabeth Cottnam Tonge (1803-1825)

Fictional
Portia (The Merchant of Venice), a character in William Shakespeares play The Merchant of Venice
Portia Quayne, the protagonist in The Death of the Heart by Elizabeth Bowen
Portia Gibbons, character on The Mighty B!