However, leukemoid reactions can resemble more serious conditions such as chronic myelogenous leukemia (CML), which can present with identical findings on the peripheral blood smear. Historically, various clues including the leukocyte alkaline phosphatase score and the presence of basophilia were used to distinguish CML from a leukemoid reaction. However, at present the test of choice in adults to distinguish CML is an assay for the presence of the Philadelphia chromosome, either via cytogenetics and FISH, or via PCR for the BCR/ABL fusion gene. The LAP (leukocyte alkaline phosphatase) score is high in reactive states but is low in CML. In cases where the diagnosis is uncertain, a qualified hematologist or oncologist should be consulted. Treatment
Treatment of underlying condition. If drug induced, discontinue drug. If the reaction is found to be from anything besides drug use, certain anti neoplastic drugs may be indicated. See also
Leukemid
Leukocytosis
Neutrophilia

References


== External links ==
Extremities may refer to:

Anatomy
The distal limb (forearm or lower leg) of a tetrapod animal, more specifically its distalmost portion, including:
Hand, a prehensile, multi-digited organ at the distal end of upper limb (arm) of bipedal primates (especially humans) that is highly adapted for grasping and fine manipulation of objects
Foot, the terminal portion of a quadruped tetrapods limb that mainly bears weight and allows terrestrial locomotion. In toe-walking ungulates, the term typically refers to the hoofed portion of the foot. Paw, a furry, padded foot with claws, common in many quadruped animals
Appendage, any external body part that protrudes outwards from an organisms core, such as a limb, tail, ear, nose, horn/antler, external genitalia, antenna, tusk/mouthpart or raptorial

Other
Extremities (play), a 1982 play by William Mastrosimone
Extremities (film), a 1986 film based on the play

See also
Extreme (disambiguation)