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- ---
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- license: mit
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- ---
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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+ ---
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+ language:
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+ - en
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+ tags:
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+ - biology
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+ - ESM
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+ - language-model
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+ - protein
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+ - VEP
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+ pretty_name: VESM scores
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+ size_categories:
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+ - 100M<n<1B
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+ ---
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+
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+ # Proteome-wide VESM variant effect scores
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+
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+ This repository provides precomputed **proteome-wide (UniProt, hg19, and hg38) variant-effect prediction scores** using the latest VESM models developed in the paper ["Compressing the collective knowledge of ESM into a single protein language model"](vesm_arxiv) by Tuan Dinh, Seon-Kyeong Jang, Noah Zaitlen and Vasilis Ntranos.
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+ - **Models:** VESM, VESM1, VESM2, VESM3, VESM++ (available at https://huggingface.co/ntranoslab/vesm).
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+
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+ ```VESM1, VESM2 and VESM3 are individual protein language models based on ESM1b, ESM2-650m and ESM3. VESM is the average of VESM1 and VESM2 (sequence-only) and VESM++ is the ensemble of all three. ```
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+
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+ Please see the corresponding GitHub repo (https://github.com/ntranoslab/vesm) for more details.
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+
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+ ## License <a name="license"></a>
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+ The predictions of VESM, VESM1, and VESM2 are distributed under the MIT License.
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+ The VESM3 and VESM++ models are built with ESM3-Open (EvolutionaryScale), which is available under a [non-commercial license agreement](https://www.evolutionaryscale.ai/policies/cambrian-open-license-agreement).