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---
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language:
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- en
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tags:
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- biology
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- ESM
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- language-model
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- protein
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- VEP
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pretty_name: VESM scores
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size_categories:
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- 100M<n<1B
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# Proteome-wide VESM variant effect scores
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This repository provides precomputed **proteome-wide (UniProt, hg19, and hg38) variant-effect prediction scores** using the latest VESM models developed in the paper ["Compressing the collective knowledge of ESM into a single protein language model"](vesm_arxiv) by Tuan Dinh, Seon-Kyeong Jang, Noah Zaitlen and Vasilis Ntranos.
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- **Models:** VESM, VESM1, VESM2, VESM3, VESM++ (available at https://huggingface.co/ntranoslab/vesm).
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```VESM1, VESM2 and VESM3 are individual protein language models based on ESM1b, ESM2-650m and ESM3. VESM is the average of VESM1 and VESM2 (sequence-only) and VESM++ is the ensemble of all three. ```
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Please see the corresponding GitHub repo (https://github.com/ntranoslab/vesm) for more details.
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## License <a name="license"></a>
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The predictions of VESM, VESM1, and VESM2 are distributed under the MIT License.
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The VESM3 and VESM++ models are built with ESM3-Open (EvolutionaryScale), which is available under a [non-commercial license agreement](https://www.evolutionaryscale.ai/policies/cambrian-open-license-agreement).
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