to treat, work, or operate with the hands, especially when knowledge and dexterity are required; to manage in hand work; to handle; as, to manipulate scientific apparatus.-to control the action of, by management; as, to manipulate a convention of delegates; to manipulate the stock market; also, to manage artfully or fraudulently; as, to manipulate accounts, or election returns.-to use the hands in dexterous operations; to do hand work; specifically, to manage the apparatus or instruments used in scientific work, or in artistic or mechanical processes; also, specifically, to use the hand in mesmeric operations.