to perform a work or labor; to exert power or strengh, physical or mechanical; to act.-to produce an appropriate physical effect; to issue in the result designed by nature; especially (med.), to take appropriate effect on the human system.-to act or produce effect on the mind; to exert moral power or influence.-to perform some manual act upon a human body in a methodical manner, and usually with instruments, with a view to restore soundness or health, as in amputation, lithotomy, etc.-to deal in stocks or any commodity with a view to speculative profits.-to produce, as an effect; to cause.-to put into, or to continue in, operation or activity; to work; as, to operate a machine.