Determine the smallest integer $n \ge 4$ for which one can choose four different numbers $a, b, c, $ and $d$ from any $n$ distinct integers such that $a+b-c-d$ is divisible by $20$ .
To determine the smallest integer \( n \ge 4 \) for which one can choose four different numbers \( a, b, c, \) and \( d \) from any \( n \) distinct integers such that \( a + b - c - d \) is divisible by \( 20 \), we can use the Pigeonhole Principle (PHP).

1. **Understanding the Problem:**
   We need to find the smallest \( n \) such that for any set of \( n \) distinct integers, there exist four numbers \( a, b, c, \) and \( d \) such that \( a + b - c - d \equiv 0 \pmod{20} \).

2. **Using the Pigeonhole Principle:**
   Consider the residues of the \( n \) integers modulo \( 20 \). There are \( 20 \) possible residues (from \( 0 \) to \( 19 \)).

3. **Counting Pairs:**
   We need to ensure that there are enough pairs of numbers such that their sums modulo \( 20 \) can cover all possible residues. The number of ways to choose 2 numbers from \( n \) is given by the binomial coefficient \( \binom{n}{2} \).

4. **Applying the Pigeonhole Principle:**
   If \( \binom{n}{2} \) (the number of pairs) is greater than \( 20 \), then by the Pigeonhole Principle, there must be at least two pairs of numbers whose sums have the same residue modulo \( 20 \).

5. **Calculating the Binomial Coefficient:**
   \[
   \binom{n}{2} = \frac{n(n-1)}{2}
   \]
   We need:
   \[
   \frac{n(n-1)}{2} > 20
   \]
   Solving for \( n \):
   \[
   n(n-1) > 40
   \]
   \[
   n^2 - n - 40 > 0
   \]
   Solving the quadratic inequality:
   \[
   n = \frac{1 \pm \sqrt{1 + 4 \cdot 40}}{2} = \frac{1 \pm \sqrt{161}}{2}
   \]
   Approximating \( \sqrt{161} \approx 12.69 \):
   \[
   n \approx \frac{1 + 12.69}{2} \approx 6.85
   \]
   Since \( n \) must be an integer, we round up to the next whole number:
   \[
   n = 7
   \]

6. **Verification:**
   For \( n = 7 \):
   \[
   \binom{7}{2} = \frac{7 \cdot 6}{2} = 21 > 20
   \]
   For \( n = 6 \):
   \[
   \binom{6}{2} = \frac{6 \cdot 5}{2} = 15 < 20
   \]
   Thus, \( n = 7 \) is the smallest integer satisfying the condition.

The final answer is \( \boxed{7} \).