The Princeton University Band plays a setlist of 8 distinct songs, 3 of which are tiring to play.  If the Band can't play any two tiring songs in a row, how many ways can the band play its 8 songs?
1. **Arrange the 5 non-tiring songs:**
   - There are 5 non-tiring songs, and they can be arranged in any order. The number of ways to arrange 5 distinct items is given by the factorial of 5:
   \[
   5! = 120
   \]

2. **Determine the slots for the tiring songs:**
   - When the 5 non-tiring songs are arranged, they create 6 possible slots where the tiring songs can be placed (before the first non-tiring song, between each pair of non-tiring songs, and after the last non-tiring song):
   \[
   \_ N \_ N \_ N \_ N \_ N \_
   \]
   - We need to choose 3 out of these 6 slots to place the tiring songs. The number of ways to choose 3 slots from 6 is given by the binomial coefficient:
   \[
   \binom{6}{3} = 20
   \]

3. **Arrange the 3 tiring songs:**
   - Once the slots are chosen, the 3 tiring songs can be arranged in these slots in any order. The number of ways to arrange 3 distinct items is given by the factorial of 3:
   \[
   3! = 6
   \]

4. **Calculate the total number of ways:**
   - Multiply the number of ways to arrange the non-tiring songs, the number of ways to choose the slots for the tiring songs, and the number of ways to arrange the tiring songs:
   \[
   120 \times 20 \times 6 = 14400
   \]

The final answer is \(\boxed{14400}\)