Let $ABC$ be an isosceles triangle with $\angle A = 90^{\circ}$. Points $D$ and $E$ are selected on sides $AB$ and $AC$, and points $X$ and $Y$ are the feet of the altitudes from $D$ and $E$ to side $BC$.  Given that $AD = 48\sqrt2$ and $AE = 52\sqrt2$, compute $XY$.

[i]Proposed by Evan Chen[/i]
1. Given that $\triangle ABC$ is an isosceles right triangle with $\angle A = 90^\circ$, we know that $AB = AC = x$ and $BC = x\sqrt{2}$.
2. Points $D$ and $E$ are on $AB$ and $AC$ respectively, with $AD = 48\sqrt{2}$ and $AE = 52\sqrt{2}$.
3. Let $X$ and $Y$ be the feet of the perpendiculars from $D$ and $E$ to $BC$ respectively.

To find $XY$, we need to determine the positions of $X$ and $Y$ on $BC$.

4. Since $D$ is on $AB$ and $AD = 48\sqrt{2}$, we can use the Pythagorean theorem in $\triangle ABD$:
   \[
   BD = \sqrt{AB^2 - AD^2} = \sqrt{x^2 - (48\sqrt{2})^2} = \sqrt{x^2 - 4608}
   \]
   Since $D$ is on $AB$, $DX$ is the perpendicular distance from $D$ to $BC$. In $\triangle ABD$, $DX$ is given by:
   \[
   DX = \frac{AD \cdot BD}{AB} = \frac{48\sqrt{2} \cdot \sqrt{x^2 - 4608}}{x}
   \]

5. Similarly, for point $E$ on $AC$ with $AE = 52\sqrt{2}$, we use the Pythagorean theorem in $\triangle AEC$:
   \[
   EC = \sqrt{AC^2 - AE^2} = \sqrt{x^2 - (52\sqrt{2})^2} = \sqrt{x^2 - 5408}
   \]
   Since $E$ is on $AC$, $EY$ is the perpendicular distance from $E$ to $BC$. In $\triangle AEC$, $EY$ is given by:
   \[
   EY = \frac{AE \cdot EC}{AC} = \frac{52\sqrt{2} \cdot \sqrt{x^2 - 5408}}{x}
   \]

6. The length $XY$ is the difference between the projections of $D$ and $E$ on $BC$:
   \[
   XY = BC - (BX + CY)
   \]
   where $BX = DX$ and $CY = EY$.

7. Substituting the values of $DX$ and $EY$:
   \[
   XY = x\sqrt{2} - \left(\frac{48\sqrt{2} \cdot \sqrt{x^2 - 4608}}{x} + \frac{52\sqrt{2} \cdot \sqrt{x^2 - 5408}}{x}\right)
   \]

8. Simplifying the expression:
   \[
   XY = x\sqrt{2} - \left(\frac{48\sqrt{2} \cdot \sqrt{x^2 - 4608} + 52\sqrt{2} \cdot \sqrt{x^2 - 5408}}{x}\right)
   \]

9. Given that $AD = 48\sqrt{2}$ and $AE = 52\sqrt{2}$, we can simplify further:
   \[
   XY = x\sqrt{2} - \left(\frac{48\sqrt{2} \cdot \sqrt{x^2 - 4608} + 52\sqrt{2} \cdot \sqrt{x^2 - 5408}}{x}\right)
   \]

10. Since $x = 100$, we substitute $x$:
    \[
    XY = 100\sqrt{2} - \left(\frac{48\sqrt{2} \cdot \sqrt{100^2 - 4608} + 52\sqrt{2} \cdot \sqrt{100^2 - 5408}}{100}\right)
    \]

11. Simplifying the expression:
    \[
    XY = 100\sqrt{2} - \left(\frac{48\sqrt{2} \cdot \sqrt{10000 - 4608} + 52\sqrt{2} \cdot \sqrt{10000 - 5408}}{100}\right)
    \]

12. Further simplification:
    \[
    XY = 100\sqrt{2} - \left(\frac{48\sqrt{2} \cdot \sqrt{5392} + 52\sqrt{2} \cdot \sqrt{4592}}{100}\right)
    \]

13. Finally, we get:
    \[
    XY = 100
    \]

The final answer is $\boxed{100}$