For all $x,y,z$ positive real numbers, find the all $c$ positive real numbers that providing
$$\frac{x^3y+y^3z+z^3x}{x+y+z}+\frac{4c}{xyz}\ge2c+2$$
1. **Initial Claim and Simplification:**
   We start by claiming that the only such number \( c \) is \( c = 1 \). To verify this, we first consider the case when \( x = y = z \). Substituting \( x = y = z \) into the inequality, we get:
   \[
   \frac{x^3y + y^3z + z^3x}{x + y + z} + \frac{4c}{xyz} \ge 2c + 2
   \]
   Since \( x = y = z \), the expression simplifies to:
   \[
   \frac{3x^4}{3x} + \frac{4c}{x^3} \ge 2c + 2
   \]
   \[
   x^3 + \frac{4c}{x^3} \ge 2c + 2
   \]

2. **Testing Specific Values:**
   To find \( c \), we test specific values of \( x \). Let \( x = \sqrt[3]{2 + 2\varepsilon} \) for \( \varepsilon > 0 \). Then:
   \[
   (\sqrt[3]{2 + 2\varepsilon})^3 + \frac{4c}{(\sqrt[3]{2 + 2\varepsilon})^3} \ge 2c + 2
   \]
   \[
   2 + 2\varepsilon + \frac{4c}{2 + 2\varepsilon} \ge 2c + 2
   \]
   Simplifying, we get:
   \[
   2 + 2\varepsilon + \frac{2c}{1 + \varepsilon} \ge 2c + 2
   \]
   \[
   2\varepsilon + \frac{2c}{1 + \varepsilon} \ge 2c
   \]
   \[
   \varepsilon + \frac{c}{1 + \varepsilon} \ge c
   \]
   \[
   \varepsilon \ge c - \frac{c}{1 + \varepsilon}
   \]
   \[
   \varepsilon \ge c \left(1 - \frac{1}{1 + \varepsilon}\right)
   \]
   \[
   \varepsilon \ge c \left(\frac{\varepsilon}{1 + \varepsilon}\right)
   \]
   \[
   \varepsilon (1 + \varepsilon) \ge c \varepsilon
   \]
   \[
   \varepsilon + \varepsilon^2 \ge c \varepsilon
   \]
   \[
   1 + \varepsilon \ge c
   \]
   Since \( \varepsilon \) can be arbitrarily small, we conclude \( c \le 1 \).

3. **Testing Another Specific Value:**
   Let \( x = \sqrt[3]{2 - 2\Delta} \) for \( \Delta > 0 \). Then:
   \[
   (\sqrt[3]{2 - 2\Delta})^3 + \frac{4c}{(\sqrt[3]{2 - 2\Delta})^3} \ge 2c + 2
   \]
   \[
   2 - 2\Delta + \frac{4c}{2 - 2\Delta} \ge 2c + 2
   \]
   Simplifying, we get:
   \[
   2 - 2\Delta + \frac{2c}{1 - \Delta} \ge 2c + 2
   \]
   \[
   -2\Delta + \frac{2c}{1 - \Delta} \ge 2c
   \]
   \[
   -\Delta + \frac{c}{1 - \Delta} \ge c
   \]
   \[
   -\Delta \ge c - \frac{c}{1 - \Delta}
   \]
   \[
   -\Delta \ge c \left(1 - \frac{1}{1 - \Delta}\right)
   \]
   \[
   -\Delta \ge c \left(\frac{-\Delta}{1 - \Delta}\right)
   \]
   \[
   \Delta (1 - \Delta) \ge c \Delta
   \]
   \[
   \Delta - \Delta^2 \ge c \Delta
   \]
   \[
   1 - \Delta \ge c
   \]
   Since \( \Delta \) can be arbitrarily small, we conclude \( c \ge 1 \).

4. **Combining Results:**
   From the above two cases, we have \( 1 + \varepsilon \ge c \ge 1 - \Delta \) for all positive \( \Delta, \varepsilon \). Since \( \varepsilon \) and \( \Delta \) can be arbitrarily small, we conclude \( c = 1 \).

5. **Verification for All Positive \( x, y, z \):**
   Now we need to prove the inequality for all positive \( x, y, z \) with \( c = 1 \):
   \[
   \frac{x^3y + y^3z + z^3x}{x + y + z} + \frac{4}{xyz} \ge 4
   \]
   We claim that:
   \[
   x^3y + y^3z + z^3x \ge xyz(x + y + z)
   \]
   This can be shown using the weighted AM-GM inequality:
   \[
   \frac{4}{7}x^3y + \frac{1}{7}y^3z + \frac{2}{7}z^3x \ge x^2yz
   \]
   Summing cyclically, we get:
   \[
   x^3y + y^3z + z^3x \ge xyz(x + y + z)
   \]
   Therefore:
   \[
   \frac{x^3y + y^3z + z^3x}{x + y + z} + \frac{4}{xyz} \ge xyz + \frac{4}{xyz}
   \]
   Using AM-GM inequality:
   \[
   xyz + \frac{4}{xyz} \ge 4
   \]
   This completes the proof.

\(\blacksquare\)

The final answer is \( \boxed{ c = 1 } \)