3. If real numbers $m, n, p, q$ satisfy the conditions
$$
\begin{array}{l}
m+n+p+q=22, \\
m p=n q=100,
\end{array}
$$

then the value of $\sqrt{(m+n)(n+p)(p+q)(q+m)}$ is
$\qquad$
3. 220 .

From the given, we have
$$
\begin{aligned}
& (m+n)(n+p)(p+q)(q+m) \\
= & {[(m+n)(p+q)][(n+p)(q+m)] } \\
= & (200+m q+n p)(200+m n+p q) \\
= & 200^{2}+100\left(m^{2}+n^{2}+p^{2}+q^{2}+2 m n+\right. \\
& 2 m q+2 n p+2 p q) \\
= & 200^{2}+100\left[(m+n+p+q)^{2}-400\right] \\
= & {[10(m+n+p+q)]^{2} . }
\end{aligned}
$$

Therefore, the original expression $=10(m+n+p+q)=220$.