1. (8 points) Calculate: $6 \times\left(\frac{1}{2}-\frac{1}{3}\right)+12 \times\left(\frac{1}{3}+\frac{1}{4}\right)+19-33+21-7+22=$ $\qquad$
【Solution】Solution: Original expression $=1+7+19-33+21-7+22$
$$
\begin{array}{l}
=(1+19)+(7-7)+(21+22)-33 \\
=20+0+(43-33) \\
=20+10 \\
=30
\end{array}
$$

Therefore, the answer is: 30