Given $r\in\mathbb{R}$. Alice and Bob plays the following game:
An equation with blank is written on the blackboard as below:
$$S=|\Box-\Box|+|\Box-\Box|+|\Box-\Box|$$
Every round, Alice choose a real number from $[0,1]$ (not necessary to be different from the numbers chosen before)  and Bob fill it in an empty box. After 6 rounds, every blank is filled and $S$ is determined at the same time. If $S\ge r$ then Alice wins, otherwise Bob wins.
Find all $r$ such that Alice can guarantee her victory.
To solve this problem, we need to analyze the game and determine the conditions under which Alice can guarantee her victory. We will start by examining the given equation and the rules of the game.

1. **Understanding the Equation:**
   The equation given is:
   \[
   S = |\Box - \Box| + |\Box - \Box| + |\Box - \Box|
   \]
   There are 6 boxes to be filled with numbers from the interval \([0, 1]\). Alice chooses a number, and Bob places it in one of the empty boxes. After 6 rounds, the value of \(S\) is determined.

2. **Analyzing the Absolute Values:**
   Each term in the sum \(S\) is an absolute difference between two numbers chosen from \([0, 1]\). The maximum value of \(|a - b|\) for \(a, b \in [0, 1]\) is 1, and the minimum value is 0.

3. **Strategy for Alice:**
   Alice's goal is to ensure that \(S \ge r\). To do this, she needs to maximize the sum of the absolute differences. The best strategy for Alice is to choose numbers that are as far apart as possible.

4. **Worst-Case Scenario for Alice:**
   Bob will try to minimize \(S\). The worst-case scenario for Alice is when Bob places the numbers in such a way that the absolute differences are minimized. For example, if Alice chooses 0 and 1 alternately, Bob can place them in pairs to minimize the differences.

5. **Calculating the Minimum Value of \(S\):**
   If Alice chooses 0 and 1 alternately, Bob can place them as follows:
   \[
   S = |0 - 1| + |0 - 1| + |0 - 1| = 1 + 1 + 1 = 3
   \]
   This is the maximum value of \(S\) when Alice chooses optimally and Bob places the numbers to minimize \(S\).

6. **Generalization for \(N\) Absolute Values:**
   For a general case with \(N\) absolute values, the equation is:
   \[
   S = |\Box - \Box| + |\Box - \Box| + \cdots + |\Box - \Box|
   \]
   with \(2N\) boxes to be filled. If Alice chooses 0 and 1 alternately, the maximum value of \(S\) is \(N\).

7. **Condition for Alice to Win:**
   Alice wins if \(S \ge r\). From the above analysis, the maximum value of \(S\) is \(N\). Therefore, Alice can guarantee her victory if:
   \[
   N \ge r
   \]

8. **Case for \(\alpha = 2\):**
   If \(\alpha = 2\), Alice needs \(S \ge 2\). For large enough \(N\), Alice can always ensure \(S \ge 2\) by choosing 0 and 1 alternately. The smallest \(N\) for which Bob has a winning strategy is when \(N < 2\).

The final answer is \( \boxed{ r \le 3 } \) for the given problem and \(N \ge r\) for the generalized problem.