Let $x=\frac{4}{(\sqrt{5}+1)(\sqrt[4]{5}+1)(\sqrt[8]{5}+1)(\sqrt[16]{5}+1)}.$ Find $(x+1)^{48}$.
We note that in general,


${} (\sqrt[2^n]{5} + 1)(\sqrt[2^n]{5} - 1) = (\sqrt[2^n]{5})^2 - 1^2 = \sqrt[2^{n-1}]{5} - 1$.


It now becomes apparent that if we multiply the [numerator](https://artofproblemsolving.com/wiki/index.php/Numerator) and [denominator](https://artofproblemsolving.com/wiki/index.php/Denominator) of $\frac{4}{ (\sqrt{5}+1) (\sqrt[4]{5}+1) (\sqrt[8]{5}+1) (\sqrt[16]{5}+1) }$ by $(\sqrt[16]{5} - 1)$, the denominator will [telescope](https://artofproblemsolving.com/wiki/index.php/Telescope) to $\sqrt[1]{5} - 1 = 4$, so 


$x = \frac{4(\sqrt[16]{5} - 1)}{4} = \sqrt[16]{5} - 1$.


It follows that $(x + 1)^{48} = (\sqrt[16]5)^{48} = 5^3 = \boxed{125}$.