1. Calculate:
$$
2^{1+2+3}-\left(2^{1}+2^{2}+2^{3}\right)=(\quad) \text {. }
$$
(A) 0
(B) 50
(C) 52
(D) 54
(E) 57
1. B.
$$
\begin{array}{l}
2^{1+2+3}-\left(2^{1}+2^{2}+2^{3}\right) \\
=2^{6}-(2+4+8)=50
\end{array}
$$