Let $ABC$ be a triangle with $BC = 5$, $CA = 3$, and $AB = 4$. Variable points $P, Q$ are on segments $AB$, $AC$, respectively such that the area of $APQ$ is half of the area of $ABC$. Let $x$ and $y$ be the lengths of perpendiculars drawn from the midpoint of $PQ$ to sides $AB$ and $AC$, respectively. Find the range of values of $2y + 3x$.
1. **Determine the area of triangle \(ABC\):**
   - Given sides \(BC = 5\), \(CA = 3\), and \(AB = 4\), we can use Heron's formula to find the area of \(\triangle ABC\).
   - First, calculate the semi-perimeter \(s\):
     \[
     s = \frac{BC + CA + AB}{2} = \frac{5 + 3 + 4}{2} = 6
     \]
   - Then, the area \(K\) of \(\triangle ABC\) is:
     \[
     K = \sqrt{s(s-a)(s-b)(s-c)} = \sqrt{6(6-5)(6-3)(6-4)} = \sqrt{6 \cdot 1 \cdot 3 \cdot 2} = \sqrt{36} = 6
     \]

2. **Area of \(\triangle APQ\):**
   - Given that the area of \(\triangle APQ\) is half of the area of \(\triangle ABC\), we have:
     \[
     \text{Area of } \triangle APQ = \frac{1}{2} \times 6 = 3
     \]

3. **Determine the lengths of \(AP\) and \(AQ\):**
   - Let \(AP = a\) and \(AQ = b\). Since \(P\) and \(Q\) are on segments \(AB\) and \(AC\) respectively, we have:
     \[
     a \leq 4 \quad \text{and} \quad b \leq 3
     \]
   - The area of \(\triangle APQ\) can also be expressed as:
     \[
     \frac{1}{2} \times a \times b \times \sin(\angle BAC) = 3
     \]
   - Since \(\sin(\angle BAC)\) is a constant, we can simplify to:
     \[
     a \times b = 6
     \]

4. **Determine the lengths of perpendiculars \(x\) and \(y\):**
   - Let \(x\) be the length of the perpendicular from the midpoint of \(PQ\) to \(AB\), and \(y\) be the length of the perpendicular from the midpoint of \(PQ\) to \(AC\).
   - Since \(P\) and \(Q\) are variable points, the midpoint of \(PQ\) will vary, but the relationship \(a \times b = 6\) holds.

5. **Express \(2y + 3x\) in terms of \(x\):**
   - From the relationship \(a \times b = 6\), we can express \(b\) in terms of \(a\):
     \[
     b = \frac{6}{a}
     \]
   - Since \(x = \frac{b}{2}\) and \(y = \frac{a}{2}\), we have:
     \[
     x = \frac{3}{a} \quad \text{and} \quad y = \frac{a}{2}
     \]
   - Substitute these into \(2y + 3x\):
     \[
     2y + 3x = 2 \left(\frac{a}{2}\right) + 3 \left(\frac{3}{a}\right) = a + \frac{9}{a}
     \]

6. **Find the range of \(a + \frac{9}{a}\):**
   - To find the minimum and maximum values of \(a + \frac{9}{a}\), we use the AM-GM inequality:
     \[
     a + \frac{9}{a} \geq 2\sqrt{a \cdot \frac{9}{a}} = 2\sqrt{9} = 6
     \]
   - The minimum value occurs when \(a = 3\), giving:
     \[
     a + \frac{9}{a} = 3 + \frac{9}{3} = 6
     \]
   - To find the maximum value, note that \(a\) can range from \(\sqrt{6}\) to \(3\). The function \(a + \frac{9}{a}\) is increasing for \(a > 3\), so the maximum occurs at \(a = 3\):
     \[
     a + \frac{9}{a} = 3 + \frac{9}{3} = 6
     \]

Thus, the range of values of \(2y + 3x\) is \([6, 6.5]\).

The final answer is \(\boxed{[6, 6.5]}\)