Place the integers $1,2 , \ldots, n^{3}$ in the cells of a $n\times n \times n$ cube such that every number appears once. For any possible enumeration, write down the maximal difference between any two adjacent cells (adjacent means having a common vertex). What is the minimal number noted down?
1. **Understanding the Problem:**
   We need to place the integers \(1, 2, \ldots, n^3\) in the cells of an \(n \times n \times n\) cube such that every number appears exactly once. We are to determine the minimal possible value of the maximal difference between any two adjacent cells (where adjacent means having a common vertex).

2. **Establishing the Path:**
   Consider a path \(c_0, c_1, \ldots, c_m\) of cells where \(c_i\) is adjacent to \(c_{i+1}\), \(c_0\) contains the number 1, and \(c_m\) contains the number \(n^3\). The existence of such a path can be seen inductively, noting that every cell of an \(n \times n \times n\) cube is adjacent to a cell of a fixed \((n-1) \times (n-1) \times (n-1)\) cube.

3. **Calculating the Difference:**
   Since the difference between the numbers in \(c_m\) and \(c_0\) is \(n^3 - 1\) and there are \(m-1 \leq n-1\) pairwise differences, we can use the pigeonhole principle to find that there is an index \(i\) such that:
   \[
   |c_{i+1} - c_i| \geq \frac{n^3 - 1}{n - 1}
   \]
   Simplifying this expression:
   \[
   \frac{n^3 - 1}{n - 1} = \frac{n^3 - 1}{n - 1} = \frac{(n-1)(n^2 + n + 1) + n - 1}{n - 1} = n^2 + n + 1
   \]
   Therefore, there is always a pair of adjacent cells with a difference of at least \(n^2 + n + 1\).

4. **Constructing an Enumeration:**
   We now describe an enumeration that has no larger differences. Consider the \(k\)-th layer of the cube (which is an \(n \times n\) square) and fill it as follows:
   \[
   \begin{pmatrix}
   (k-1)n^2 + 1 & (k-1)n^2 + 2 & (k-1)n^2 + 3 & \ldots & (k-1)n^2 + n \\
   (k-1)n^2 + n + 1 & (k-1)n^2 + n + 2 & (k-1)n^2 + n + 3 & \ldots & (k-1)n^2 + 2n \\
   \vdots & \vdots & \vdots & \ddots & \vdots \\
   (k-1)n^2 + (n-1)n + 1 & (k-1)n^2 + (n-1)n + 2 & (k-1)n^2 + (n-1)n + 3 & \ldots & k n^2
   \end{pmatrix}
   \]
   One can check that this satisfies the condition, ensuring that the maximal difference between any two adjacent cells is \(n^2 + n + 1\).

The final answer is \(\boxed{n^2 + n + 1}\)