If $S =  6 \times10 000 +5\times 1000+ 4 \times 10+ 3  \times 1$, what is $S$?

$\textbf{(A)}\ 6543 \qquad \textbf{(B)}\ 65043 \qquad \textbf{(C)}\ 65431 \qquad \textbf{(D)}\ 65403 \qquad \textbf{(E)}\ 60541$
1. The given expression is \( S = 6 \times 10,000 + 5 \times 1,000 + 4 \times 10 + 3 \times 1 \).
2. We can rewrite the expression using powers of 10:
   \[
   S = 6 \times 10^4 + 5 \times 10^3 + 4 \times 10^1 + 3 \times 10^0
   \]
3. Calculate each term separately:
   \[
   6 \times 10^4 = 6 \times 10,000 = 60,000
   \]
   \[
   5 \times 10^3 = 5 \times 1,000 = 5,000
   \]
   \[
   4 \times 10^1 = 4 \times 10 = 40
   \]
   \[
   3 \times 10^0 = 3 \times 1 = 3
   \]
4. Sum all the calculated values:
   \[
   S = 60,000 + 5,000 + 40 + 3
   \]
5. Perform the addition step-by-step:
   \[
   60,000 + 5,000 = 65,000
   \]
   \[
   65,000 + 40 = 65,040
   \]
   \[
   65,040 + 3 = 65,043
   \]

The final answer is \(\boxed{65043}\).