The expression $(81)^{-2^{-2}}$ has the same value as:
$\textbf{(A)}\ \frac {1}{81} \qquad \textbf{(B) }\ \frac {1}{3} \qquad \textbf{(C) }\ 3 \qquad \textbf{(D) }\ 81\qquad \textbf{(E) }\ 81^4$
Let us recall $\text{PEMDAS}$. We  calculate the exponent first. $(-2)^{-2}=\frac{1}{(-2)^2}=\frac{1}{4}$ When we substitute, we get $81^{\frac{1}{4}}=\sqrt[4]{81}=\boxed{\textbf{(C) }3}$.
~Mathfun1000