1. In the expansion of the polynomial $(x-1)^{3}(x+2)^{10}$, the coefficient of $x^{6}$ is $\qquad$
$$
\begin{array}{l}
C_{3}^{0}(-1)^{3} \cdot C_{10}^{6} \cdot 2^{4}+C_{3}^{1}(-1)^{2} \cdot C_{10}^{5} \cdot 2^{5}+C_{3}^{2}(-1)^{1} \cdot C_{10}^{4} \cdot 2^{6}+C_{3}^{3}(-1)^{0} \cdot C_{10}^{3} \cdot 2^{7} \\
=-210 \cdot 16+3 \cdot 252 \cdot 32-3 \cdot 210 \cdot 64+120 \cdot 128=-4128 .
\end{array}
$$

The translation is as follows:

$$
\begin{array}{l}
C_{3}^{0}(-1)^{3} \cdot C_{10}^{6} \cdot 2^{4}+C_{3}^{1}(-1)^{2} \cdot C_{10}^{5} \cdot 2^{5}+C_{3}^{2}(-1)^{1} \cdot C_{10}^{4} \cdot 2^{6}+C_{3}^{3}(-1)^{0} \cdot C_{10}^{3} \cdot 2^{7} \\
=-210 \cdot 16+3 \cdot 252 \cdot 32-3 \cdot 210 \cdot 64+120 \cdot 128=-4128 .
\end{array}
$$