4. (8 points) Please fill in the 10 boxes in the figure with the numbers $0 \sim 9$ respectively, so that the subtraction equation holds. If the digits “6” and “1” are filled in the first two boxes of the minuend, respectively, then the difference of the equation is $\qquad$ .


【Solution】Solution: According to the problem, we know:
First, determine that the first digit of the result must be 5, because the hundreds place has 0, and there is no borrowing, so the thousand place digit of the result must be 9.

Among the remaining numbers $0,2,3,4,6,7,8$.
The combinations that fit the last digit are $7+5=12, 8+5=13$.
When the last digit is the $8+5$ combination, there are no numbers that meet the condition.
When the last digit is the $7+5=12$ combination. The tens place digit needs to borrow from the hundreds place to meet the condition, and at the same time, the hundreds place digits differ by
1. Analysis shows:

Therefore, the answer is: 59387