The product
$$\left(\frac{1+1}{1^2+1}+\frac{1}{4}\right)\left(\frac{2+1}{2^2+1}+\frac{1}{4}\right)\left(\frac{3+1}{3^2+1}+\frac{1}{4}\right)\cdots\left(\frac{2022+1}{2022^2+1}+\frac{1}{4}\right)$$
can be written as $\frac{q}{2^r\cdot s}$, where $r$ is a positive integer, and $q$ and $s$ are relatively prime odd positive integers. Find $s$.

1. Consider the given product:
   \[
   \left(\frac{1+1}{1^2+1}+\frac{1}{4}\right)\left(\frac{2+1}{2^2+1}+\frac{1}{4}\right)\left(\frac{3+1}{3^2+1}+\frac{1}{4}\right)\cdots\left(\frac{2022+1}{2022^2+1}+\frac{1}{4}\right)
   \]

2. Simplify each term in the product:
   \[
   \frac{x+1}{x^2+1} + \frac{1}{4} = \frac{4(x+1) + x^2 + 1}{4(x^2 + 1)} = \frac{x^2 + 4x + 5}{4(x^2 + 1)}
   \]

3. Notice that \(x^2 + 4x + 5\) can be rewritten using the identity \((x+2)^2 + 1\):
   \[
   x^2 + 4x + 5 = (x+2)^2 + 1
   \]

4. Substitute this back into the expression:
   \[
   \frac{(x+2)^2 + 1}{4(x^2 + 1)}
   \]

5. The product now becomes:
   \[
   \prod_{x=1}^{2022} \left( \frac{(x+2)^2 + 1}{4(x^2 + 1)} \right)
   \]

6. Factor out the constant term \( \frac{1}{4} \) from each term:
   \[
   \left( \frac{1}{4} \right)^{2022} \prod_{x=1}^{2022} \left( \frac{(x+2)^2 + 1}{x^2 + 1} \right)
   \]

7. Simplify the product inside:
   \[
   \prod_{x=1}^{2022} \left( \frac{(x+2)^2 + 1}{x^2 + 1} \right)
   \]

8. Notice that the numerator and denominator form a telescoping product:
   \[
   \frac{(3^2 + 1)}{(1^2 + 1)} \cdot \frac{(4^2 + 1)}{(2^2 + 1)} \cdot \frac{(5^2 + 1)}{(3^2 + 1)} \cdots \frac{(2024^2 + 1)}{(2022^2 + 1)}
   \]

9. Most terms cancel out, leaving:
   \[
   \frac{2024^2 + 1}{2^2 + 1} = \frac{2024^2 + 1}{5}
   \]

10. Combine this with the constant term:
    \[
    \left( \frac{1}{4} \right)^{2022} \cdot \frac{2024^2 + 1}{5}
    \]

11. Express the final result in the form \( \frac{q}{2^r \cdot s} \):
    \[
    \frac{2024^2 + 1}{4^{2022} \cdot 5}
    \]

12. Since \(4^{2022} = (2^2)^{2022} = 2^{4044}\), we have:
    \[
    \frac{2024^2 + 1}{2^{4044} \cdot 5}
    \]

13. Identify \(q\), \(r\), and \(s\):
    \[
    q = 2024^2 + 1, \quad r = 4044, \quad s = 5
    \]

The final answer is \( \boxed{5} \).