1. Calculate: $45 \times 1234321-3333 \times 9999=$
\begin{aligned} \text { 【Analysis】Original expression } & =5 \times 9 \times 1111 \times 1111-3 \times 1111 \times 9 \times 1111 \\ & =(45-27) \times 1111 \times 1111 \\ & =18 \times 1111 \times 1111 \\ & =22217778\end{aligned}