How many of the numbers
\[ 
a_1\cdot 5^1+a_2\cdot 5^2+a_3\cdot 5^3+a_4\cdot 5^4+a_5\cdot 5^5+a_6\cdot 5^6
\]
are negative if $a_1,a_2,a_3,a_4,a_5,a_6 \in \{-1,0,1 \}$?

$ 
\textbf{(A)}\ 121
\qquad\textbf{(B)}\ 224
\qquad\textbf{(C)}\ 275
\qquad\textbf{(D)}\ 364
\qquad\textbf{(E)}\ 375
$
1. We start by analyzing the given expression:
   \[
   a_1 \cdot 5^1 + a_2 \cdot 5^2 + a_3 \cdot 5^3 + a_4 \cdot 5^4 + a_5 \cdot 5^5 + a_6 \cdot 5^6
   \]
   where \(a_1, a_2, a_3, a_4, a_5, a_6 \in \{-1, 0, 1\}\).

2. To determine when the expression is negative, we need to consider the contributions of each term. Notice that the powers of 5 increase rapidly:
   \[
   5 < 5^2 < 5^3 < 5^4 < 5^5 < 5^6
   \]
   This implies that the term with the highest power of 5 will dominate the sum.

3. The expression will be negative if the last nonzero coefficient \(a_i\) is \(-1\). This is because the term with the highest power of 5 will have the largest magnitude and will determine the sign of the sum.

4. We need to count the number of ways to assign values to \(a_1, a_2, a_3, a_4, a_5, a_6\) such that the last nonzero coefficient is \(-1\).

5. Consider the cases:
   - \(a_6 = -1\): The remaining coefficients \(a_1, a_2, a_3, a_4, a_5\) can be any of \(-1, 0, 1\). There are \(3^5\) such combinations.
   - \(a_6 = 0\) and \(a_5 = -1\): The remaining coefficients \(a_1, a_2, a_3, a_4\) can be any of \(-1, 0, 1\). There are \(3^4\) such combinations.
   - \(a_6 = a_5 = 0\) and \(a_4 = -1\): The remaining coefficients \(a_1, a_2, a_3\) can be any of \(-1, 0, 1\). There are \(3^3\) such combinations.
   - \(a_6 = a_5 = a_4 = 0\) and \(a_3 = -1\): The remaining coefficients \(a_1, a_2\) can be any of \(-1, 0, 1\). There are \(3^2\) such combinations.
   - \(a_6 = a_5 = a_4 = a_3 = 0\) and \(a_2 = -1\): The remaining coefficient \(a_1\) can be any of \(-1, 0, 1\). There are \(3^1\) such combinations.
   - \(a_6 = a_5 = a_4 = a_3 = a_2 = 0\) and \(a_1 = -1\): There is \(3^0 = 1\) such combination.

6. Summing these cases, we get:
   \[
   3^5 + 3^4 + 3^3 + 3^2 + 3^1 + 3^0
   \]

7. Calculating the sum:
   \[
   3^5 = 243, \quad 3^4 = 81, \quad 3^3 = 27, \quad 3^2 = 9, \quad 3^1 = 3, \quad 3^0 = 1
   \]
   \[
   243 + 81 + 27 + 9 + 3 + 1 = 364
   \]

8. Therefore, the number of negative numbers is:
   \[
   \boxed{364}
   \]