	Normally, no extra medical intervention is required when maternal Rh status is RhD+, nor RhD- mothers going through first pregnancy. However, in the case of a sensitised RhD- mother (previously conceived an RhD+ child) and the foetus being Rh+, medication such as anti-D immunoglobulin will be given to the RhD- mother. Injecting RhD- mother with anti-D immunoglobulin has been proven effective in avoiding the sensitisation of RhD+ antigen, even though the mechanism of how this medication works remains obscure. Anti-D immunoglobulin injection is also offered to RhD- individuals who have been mistakenly transfused with RhD+ blood.