For 2008, d'Ambrosio raced in both the GP2 Series and the new GP2 Asia Series. He finished eleventh in the GP2 drivers' championship. In the 2008-09 GP2 Asia Series season, d'Ambrosio finished second to team-mate Kamui Kobayashi. In the 2009 season, he finished ninth with out wining a single race. In 2010, d'Ambrosio took his first series victory at Monaco. He took his first GP2 pole position at Belgian. He finished twelfth in the drivers' championship.