	The St. Joe Missouri and North Arkansas Railroad Depot is a historic railroad station on the south side of United States Route 65 in the center of St. Joe, Arkansas. It is a typical long rectangular building, with a gable-on-hip roof, and a telegrapher's booth projecting out the north (originally track-facing) side. Built in about 1912 by the Missouri and North Arkansas Railroad, it is the only one of that railroad's wood-frame depots to survive in the state, and is the only railroad depot in Searcy County in its original location. The town of St. Joe was incorporated in 1902 as a railroad town.