	Hoyer entered the 2010 preseason as Brady's only backup. During the preseason, Hoyer completed 32-of-57 passes for 471 yards and three touchdowns, with one interception and four sacks. He saw his first action of the regular season late in a 34–14 loss to the Cleveland Browns, throwing his first NFL interception. In Week 17, against the Miami Dolphins, he threw a 42-yard touchdown pass to wide receiver Brandon Tate for his first NFL touchdown pass.