This observation coupled with the capacity of sporangia of the race affected (1.2.3.4) for the uptake and interconversion of purines, as demonstrated by experiments with labelled purines under in vivo and in vitro conditions, pointed to hypoxanthine as a key intermediate in the purine metabolism directly associated with spore formation and development.
Par contre, la germination est presque tout à fait arretée lorsque les suspensions de spores ont subits traitement de l'analogue purique, le benzimidazole, et aussi des composés le dinitrophénol et l'azoture de sodium.