question: Background: Vaccination programs are effective only when a significant percentage of people are vaccinated. However, vaccine acceptance varies among communities around the world. Social media usage is arguably one of the factors affecting public attitudes towards vaccines. Objective: This study aims to identify if the social media usages factors can be used to predict attitudes and behavior towards the COVID-19 vaccines among the people in the Arab world. Methods: An online survey was conducted in the Arab countries and 217 Arab people participated in this study. Logistic regression was applied to identify what demographics and social media usage factors predict public attitudes and behavior towards the COVID-19 vaccines. Results: Of the 217 participants, 56.22% of them were willing to accept the vaccine and 41.47% of them were hesitant. This study shows that none of the social media usages factors were significant enough to predict the actual vaccine acceptance behavior. Whereas the analysis showed few of the social media usage factors can predict public attitudes towards the COVID-19 vaccines. For example, frequent social media users were 2.85 times more likely to agree that the risk of COVID-19 is being exaggerated (OR=2.85, 95% CI=0.86-9.45, p=0.046) than infrequent social media users. Whereas participants having more trust in vaccine information shared by their contacts are less likely to agree that decision-makers have verified that vaccines are safe (OR=0.528, 95% CI= 0.276-1.012, p=0.05). Conclusion: The use of social media and information shared on it may affect public attitudes towards COVID-19 vaccines. Therefore, disseminating correct and validated information about COVID-19 and other vaccines on social media is important for increasing public trust and countering the impact of incorrect and misinformation.