question: I have Wegeners. Last Rituxan infusion Jan 2013 and Prednisone free since Nov 2013. I was taking Plaquenil and the occasional Diclofenac and have weaned off those completely as well. It has been about a month medication free and I am having a flare. My doctor is on vacation and I m not sure what to do. Severe joint aches in back, knee and elbow as well as increased inflammation in right ear. Prednisone? If so how much. Also do I start taking Plaquenil again...it will take a while to get back into my system. If I take prednisone without a maintenance drug in my system will my body be reliant upon it?