question: Q:A 42-year-old African American woman presents to the physician’s office complaining of sudden onset chest pain. She describes the pain as sharp, non-radiating with improvement when she is sitting up and leaning forward. She denies fever, chills, or a cough, but she has had swollen hands and wrists for the past 3 weeks. Medical history is significant for chronic hypertension. She had an appendectomy at age 12. Medications include hydralazine and folic acid. Vital signs are normal except for a low-grade fever. On examination, the patient is in mild distress, especially in the supine position. The metacarpophalangeal and proximal interphalangeal joints are swollen and tender bilaterally. ECG shows diffuse ST elevations. Her antinuclear antibody is negative. Which of the following additional antibodies are expected to be found in this patient’s serum?? 
  {'A': 'Anti-topoisomerase I antibodies', 'B': 'Anti-histone antibodies', 'C': 'Anti-cardiolipin antibodies', 'D': 'Anti-mitochondrial antibodies', 'E': 'Anti-cyclic citrullinated antibodies'},