question: Coronavirus disease 2019 (COVID-19) is the current biggest health problem that has caused pandemic in hundreds of countries worldwide Important efforts for COVID-19 prevention and management have been implemented by WHO and many countries;however, the number of new cases is still increasing The objective of this review is to formulate appropriate strategies to tackle COVID-19 pandemic using molecular mechanisms-based approach COVID-19 preventive measures aim to avoid virus entry to human cells by applying physical distancing, hand washing and personal protective equipment, maintaining good immune system by balanced nutrition and physical exercise, developing vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on comprehensive analysis on SARS-CoV-2 antigen presentation and subsequent immunological cascades, considering the patients' clinical condition including biomolecular parameters, and developing drugs by designing inhibitors for SARS-CoV-2 proteins responsible for virus replication and transcription