question: Q:A 35-year-old woman comes to the physician because of a 2-month history of progressive fatigue and intermittent abdominal pain. During this time, she has noticed that her urine is darker when she wakes up in the morning. Her stool is of normal color. Five months ago, she was diagnosed with type 2 diabetes mellitus, for which she takes metformin. Physical examination shows pallor and jaundice. There is no splenomegaly. Laboratory studies show:
  Hemoglobin 7.5 g/dL
  WBC count 3,500/mm3
  Platelet count 100,000/mm3
  Serum
  Creatinine 1.0 mg/dL
  Total bilirubin 6.0 mg/dL
  Direct bilirubin 0.2 mg/dl
  Lactate dehydrogenase 660 U/L
  Haptoglobin 18 mg/dL (N=41–165 mg/dL)
  Her urine is red, but urinalysis shows no RBCs. A Coombs test is negative. Peripheral blood smear shows no abnormalities. This patient is at greatest risk for which of the following complications?"? 
  {'A': 'Cholesterol gallstones', 'B': 'Acrocyanosis', 'C': 'Hepatocellular carcinoma', 'D': 'Venous thrombosis', 'E': 'Chronic lymphocytic leukemia'},