question: Q:An experimental drug, ES 62, is being studied. It prohibits the growth of vancomycin-resistant Staphylococcus aureus. It is highly lipid-soluble. The experimental design is dependent on a certain plasma concentration of the drug. The target plasma concentration is 100 mmol/dL. Which of the following factors is most important for calculating the appropriate loading dose? ? 
  {'A': 'Rate of administration', 'B': 'Clearance of the drug', 'C': 'Half-life of the drug', 'D': 'Therapeutic index', 'E': 'Volume of distribution'},