question: In contrast, analyses of 158 SNPs in 11 genes involved in AD including BIN1, CLU, CR1, and PICALM showed no significant association with cognitive phenotypes such as a test of verbal fluency similar to the WFT in 505 participants from the Lothian Birth Cohort of 1921(mean age 79.1 years) and 998 participants from the Lothian Birth Cohort of 1936 (mean age 69.6 years) [Hamilton et al  2011]. 