question: Hello doctor,  I am married for over three years. In these three years, I had five miscarriages. First three times I had miscarriages in the second and third month (due to missed heart beat of the baby) then in the fourth time I had the termination of pregnancy in the sixth month (due to low amniotic fluid level of the baby) it is found in the fifth month scan but baby parts are found normal. Again for the fifth time I had a medical abortion due to no heart beat in the baby. I undergo all medical tests HSG Scan, thyroid, prolactin, anti cardiolipin Ab IgG, anti cardiolipin Ab IgM, partial thromboplastin time (aPTT), HbA1c, LH, FSH, Estradiol - 17 b (E2), platelet count, hemoglobin, prothrombin time (PT), control (PT), INR, bleeding time and clothing time, etc. And in the karyotype test done for me and my husband reports that chromosome analysis of culture peripheral blood lymphocytes cells revealed a normal female karyotype. No clonal numerical or structural abnormalities were noted. A variant in one of the chromosome 9 was observed with an additional heterochromatin region on the long arm. Rest of that everything is normal. In that sixth month termination of pregnancy I took injection Heparin 5000 iu daily once, Ecosprin 75 mg, Porgy ova 2 mg, Duphaston 10 mg, Folvete 5 mg. Even though my pregnancy terminated due to severe oligohydramnios. But till now I did not find any solution to my problem and the doctor too was also not able to find out what is the problem. They are telling its unexplainable thing. Please give some suggestions for me. Four months passed away for the last miscarriage. Now give me some suggestion for the next step.