question: Hi, I had a heart attack in June 2011. I have complex intraatrial septum with aneurysmal fossa ovalis. I have normal arteries.I am being treated with Bisoprolol 10mg, warfarin 2mg, ramipril 2.5mg and pravastatin 20mg. I have had one positive lupus anticoagulant result and am waiting on a second result. I am experiencing a very cold left foot in the evening with numbness that can happen day or night and when walking which is making my life very difficult; i also get bad back pain which again makes walking almost impossible. I am wondering if the Bisoprolol is to blame? Any thoughts on the matter would be appreciated. Sharon.