question: Q:A 22-year-old Caucasian female presents with severe right lower quadrant pain, malaise, and diarrhea. The physician performs an endoscopy and finds disease involvement in the terminal ileum, noting that that the disease process is patchy with normal intervening mucosa. The entire wall of the region is thickened and inflamed, which may directly lead to formation of:? 
  {'A': 'Fistulas', 'B': 'Toxic megacolon', 'C': 'Widening of the intestinal lumen', 'D': 'Plummer-Vinson syndrome', 'E': 'Paneth cell metaplasia'},