question: I HAVE HAD MS FOR 14 YRS. I HAVE BEEN ON TYSABRI FOR 2 YEARS. I TESTED NEGATIVE FOR THE Jc virus INITIALLY BUT LAST MONTH I TESTED POSITIVE. MY DR WANTS TO RETEST ME AND I MAY HAVE TO GO TO A DIFFERENT MS TREATMENT BECUASE OF THE OBVIOUS RISK OF PML. I HAVE BEEN ON AVONEX, COPAXONE, REBIF AND BETASERONE AND THE TYSABRI HAS WORKED WONDERS..NO NEW LESIONS AND NO SIDE EFFECTS. I WAS ALSO JUST DIAGNOSED WITH UCTD AND WILL START ON PLEQUENIL NEXT WEEK. WHAT ALTERNATIVE MS TREATMENT SHOULD WE EXPLORE? AND IS IT COMMON TO GET UCTD WHEN YOU ALREADY HAVE MS?