question: The COVID-19 pandemic presents unprecedented challenges and uncertainties for families Guided by uncertainty management theory, this study qualitatively explored mothers’ sources of COVID-related uncertainties for their older children and the strategies used to manage their uncertainties Twenty-five mothers in the U S Midwest were interviewed by telephone between March-May 2020 during the early pandemic months Data indicated four sources of uncertainty: adjustment, threat of COVID-19, COVID-19 information, and social interaction Protective behaviors used to manage threat of COVID-19 uncertainties (e g , social distancing and isolation) sometimes unleashed further uncertainties about social interactions with others that mothers were still attempting to manage The findings suggest theoretical implications of uncertainty management theory as it applies to COVID-19 and practical implications for empowering mothers with tools for support and health literacy skills to understand and act on credible COVID-19 information [ABSTRACT FROM AUTHOR] Copyright of Journal of Family Communication is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )