question: I was put on Macrobid 100mg 2x daily for a UTI they found in the ER when I came in for intense flank pain. The first dose was given to me in the ER because I am allergic to other antibiotics. I had no problems with first dose but I was also on tramadol, bentyl, and zofran. This morning I took the macrobid after a large breakfast with a full glass of water. 5 minutes later I felt an intense adrenaline rush and had to get up and walk around. My throats felt a little full and sore. 40 minutes later my vision got blurry and I felt like I was having the worse panic attack of my life, I was trembling. I felt short of breath. I took a Benadryl just in case. I don t have any symptoms anymore. I m wondering if I was having an adverse or allergic reaction, but I don t know why I didn t have one with my first dose. I am also on doxycycline for Lyme but hadn t taken it yet. It was a very scary feeling but I also don t want a kidney infection, and I need something I can take along with my doxy. My heart palpitations I sometimes get are a little aggravated now.