question: Hello doctor, I am doing research regarding diagnosis and treatment of mental illnesses. Please answer a few questions of mine. What routine medical examinations apart from MMSE and history would you conduct? By this I mean standard routine blood investigations plus other investigations. What clinical signs would suggest performing MRI scan and would you order it with every patient? What clinical signs would suggest performing thyroid hormone tests? Would you do the thyroid hormone test with every patient admitted to the ward? Would it be a standard psychiatric procedure? What neurological and physical examinations would you conduct to rule out any other medical or neurological disorders? Schizophrenia is a dysfunction of brain’s physiology; the functioning through neurotransmitters and through hormones but actually genetic problem is always there; means there is a dysfunction at cellular level. Which neurotransmitters and hormones would be responsible for this dysfunction? What kind of dysfunction of cellular level is that? What does an elevated level of homocysteine found in schizophrenic patients tell the psychiatrist?