question: PURPOSE: Nurses have an increased risk for acquiring COVID-19 infection. This study assessed levels of risk for exposure to COVID-19 among nurses, and determined those at the greatest risk. DESIGN: A cross-sectional design was used to assess risk for exposure to COVID-19 in nurses from five randomly selected governmental hospitals in the United Arab Emirates. Participants completed an online survey (including the World Health Organization survey) to assess their risk for exposure to COVID-19. Descriptive statistics were used to describe classes of risk for exposure, and logistic regression was used to identify factors associated with greater risk. FINDINGS: Of the 552 participants, 284 nurses (51.4%) were classified at high risk for COVID-19 exposure as they did not report adherence to infection control and prevention (ICP) guidelines at all times during healthcare interactions and when performing aerosol procedures, or had accidental exposure to biological fluid and respiratory secretions. Compared with adherence to wearing medical masks, gloves, and hand hygiene practices, adherence to wearing face shields or goggles and disposable gowns and decontaminating high-touch surfaces was less frequent. Shifting to work in critical care units, not having adequate critical care experience, and reporting a need for training in ICP practices were factors that contributed to high-risk exposure (p values for Ex (Bs) = 2.60, 2.16, 1.75, &#8804; 0.05, consecutively). CONCLUSIONS: A considerable number of nurses were classified at high risk for COVID-19 exposure. Critical care work experience and adequate evidence-based training in ICP practices related to COVID-19 must be considered to mitigate the risk for exposure to COVID-19 in nurses. CLINICAL RELEVANCE: This study provided a strong message regarding protecting nurses at high risk for exposure to COVID-19. Clinical leaders must stay vigilant to ensure nurses' adherence to ICP practices in the context of COVID-19, and to proactively address any related deficits.