question: Background: Home treatment of patients affected by COVID-19 is still a matter of daily debate During the clinical evolution of the disease, there are high risks of lung failure, which requires oxygen therapy Here, we report our clinical experience with at-home treatment using high-flow nasal cannula in non-hospitalised patients with confirmed COVID-19 Patients and methods: In this study, 18 patients with moderate-to-severe respiratory failure secondary to COVID-19 were monitored at home daily for temperature and SpO2 measurements Other parameters such as saturation of peripheral oxygen (SpO2), SpO2/FiO2 (fraction of inspired oxygen), temperature, and lung performance were monitored periodically Depending on oxygen requirements, the patients also received either standard oxygen via a face mask or, if higher FiO2 required, high-flow nasal cannula (HFNC) Results: All 18 patients had favourable outcomes and recovered from COVID-19 No death was recorded in this group Conclusion: Our clinical experience proves that high-flow nasal cannula oxygen therapy may be considered for at-home treatment of COVID-19 patients with moderate lung failure This could be useful for further treatment during the pandemic and may also be considered in future epidemics