question: Q:A 45-year-old man is brought to the physician by his wife because of difficulty sleeping and poor appetite for the past 4 weeks. During this period, he also has had persistent sadness and difficulty concentrating on tasks, because of which he has been reprimanded at work for poor performance. Over the past 3 years, he has often had such phases, with a maximum symptom-free gap of one month between each of them. His behavior is causing a strain in his relationships with his wife and children. His mother died 4 months ago from breast cancer. Physical examination shows no abnormalities. Mental status examination shows a depressed mood and constricted affect. What is the most likely diagnosis in this patient?? 
  {'A': 'Persistent depressive disorder', 'B': 'Adjustment disorder with depressed mood', 'C': 'Bipolar affective disorder', 'D': 'Major depressive disorder', 'E': 'Persistent complex bereavement disorder'},