question: Q:A 28-year-old woman presents to the clinic with complaints of occasional low-grade fever and joint pain for 1 month. She also complains of morning stiffness in the proximal interphalangeal joints of both hands, which lasts for 5 to 10 minutes. She recently noticed a pink rash on her nose and cheekbones. Her family history is significant for similar complaints in her mother. She is not taking any medications. On examination, her temperature is 37.6°C (99.6°F), pulse is 74/min, blood pressure is 110/70 mm Hg, and respirations are 18/min. Aphthous ulcers are noted on her oral mucosa. Which of the following tests would be most specific for confirming the diagnosis in this patient?? 
  {'A': 'Anti-double stranded DNA (dsDNA) antibodies', 'B': 'Anti-histone antibodies', 'C': 'Anti-topoisomerase (anti-Scl 70) antibodies', 'D': 'Anti-Ro antibodies', 'E': 'Antinuclear antibodies (ANA)'},