question: OBJECTIVES: We aimed to investigate the factors affecting mortality of patients aged ?65 years who were hospitalized with the diagnosis of new coronavirus pneumonia (COVID-19). METHODS: This is a retrospective study of ?65 years paients with COVID-19 who were hospitalized in Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty between March 11 and May 28, 2020. Demographic, clinical, treatment and laboratory data were extracted from electronic medical records. We used univariate and multivariable logistic regression methods to explore the risk factors for in hospital death. RESULTS: 218 patients (112 men, 106 women) were included, of whom 166 were discharged and 52 died in hospital. With univariate analysis, various clinical features and laboratory variables were found to be significantly different (ie P <0.05). In multivariate logistic regression analysis; present malignancy (odds ratio [OR]= 4.817, 95% confidence interval [CI]= 1.107-20.958, p:0.036), dyspnea (OR=4.652, 95% CI=1.473-14.688, p:0.009), Neutrophil/lymphocyte ratio (NRL) (OR=1.097, 95% CI=1.012-1.188, p: 0.025), the highest values of CRP (OR=1.006, 95% CI=1.000-1.012, p: 0.049), LDH (OR=1.002, 95% CI=1.001-1.004, p: 0.003) and creatinine levels (OR=1.497, 95% CI=1.126-1.990, p: 0.006), SpO2 values on admission (OR=0.897, 95% CI=0.811-0.993, p: 0.036) and azithromycin use (OR=0.239, 95% CI=0.065-0.874, p: 0.031) were independently associated with mortality. CONCLUSION: The presence of malignancy, symptoms of dyspnea, high NLR, highest CRP, LDH and creatinine levels, low saturation on admission predicted mortality, while the azithromycin use was found to be protective against mortality. Therefore, knowing the causes predicting mortality is important in order to be more successful in the future cases.