question: The coronavirus disease 2019 pandemic is having a major impact on healthcare systems worldwide Several months after the COVID-19 outbreak, waiting lists of non-urgent structural heart (SH) interventions continue to increase Limitations in terms of ICU beds and anesthesiology represent a major limitation to conduct non-urgent SH interventions and are a valid reason to move towards less invasive approaches The field of left atrial appendage occlusion (LAAO) reflects this challenging situation perfectly The aim of this paper is to describe the possibilities for pre-procedural LAA assessment, performance of the LAAO procedure and post-procedural surveillance in these challenging times