question: Diabetes is the greatest public condition among patients with coronavirus disease and has been found to affect prognosis worldwide It is revealed that hyperglycemia is one of the elements that elevates the risk of consequences in these persons This study designed to analysis the overall features of the novel coronavirus and provide an understanding of the coronavirus disease in diabetic patients, and its treatment These patients are usually treated with various medications and this review clarify the role of metformin and dipeptidyl peptidase 4 inhibitors as helpful factors in these patients Recommendations are made on the probable pathophysiological mechanisms of the association between coronavirus and diabetes, and its management Additional study about this association and its clinical managing is necessary © 2021, Institute of Medico-Legal Publications All rights reserved