question: Meaningful recognition from nurse managers is considered a powerful tool for improving staff nurses’ psychological capital to deal effectively with stressful challenges they are exposed to during the COVID-19 pandemic through raising their sense of coherence (SOC) and improving their self-efficacy Aim: This study aimed to assess the effect of nurse managers’ meaningful recognition program on staff nurses’ sense of coherence and self-efficacy Design: A quasi-experimental, one-group (pretest-posttest) research design was used Setting: This study was conducted at Shebin El Kom Teaching Hospital, Menoufia Governorate, Egypt Sample: A purposive sample of 35 nurse managers and 50 staff nurses Data collection tools: Three tools were used;Recognition Behavior Questionnaire, General Self-efficacy Likert Scale, and Sense of Coherence Scale (SOC), in addition to demographic characteristics Results: There was a highly statistically significant improvement of the total recognition behavior of nurse managers and its subscales as reported by staff nurses after implementation of the program and on follow up than before (P&lt;0 01) Additionally, there was a statistically significant improvement in the mean scores of the sense of coherence and self-efficacy of staff nurses after implementation of the program and on follow up than before (P&lt;0 001) Conclusion: The nurse managers' recognition program was effective in improving staff nurses' sense of coherence and self-efficacy Recommendation: Meaningful recognition behavior program can be widely adopted and applied for the nurses and all health care teams in different health care settings especially in such a stressful period due to the COVID-19 pandemic