question: I was prescribed clomipramine three years following a nervous breakdown that left me unable to sleep more than a couple of hours a night, at best. It worked so well that after being on the drug for three years the doctor I was seeing decide to take me off it. Following a long taper, I went about two weeks free of the drug before relapsing. Reintroduction of clomipramine proved ineffective. I have tried over 40 different medications over the span of 20 years without finding any lasting success. I have a bad anxiety problem that seems to be totally unrelated to my day to day existence. Did I make a mistake by going on medication in the first place? Should I just throw in the towel on meds? They don t work anyway, and I ve tried just about all possible meds for sleep and anxiety.