question: Q:A 13-year-old girl is brought to the pediatrician due to a 4-month history of heavy vaginal bleeding during menstrual periods. She endorses episodes of bleeding gums after brushing her teeth and experienced prolonged bleeding after tonsillectomy 6 years ago. Her mother states that she bled significantly during childbirth and that the girl’s older brother has similar symptoms including easy bruising. Vitals were stable and physical exam was not revealing. Laboratory studies show:
  
  Platelet count: 72,000/mm^3
  Bleeding time: 14 min
  Prothrombin time: 12 secs (INR = 1)
  Partial thromboplastin time: 40 secs
  
  Blood smear demonstrates increased megakaryocytes and enlarged platelets. Platelets do not aggregate to ristocetin. Which of the following is the most likely diagnosis?? 
  {'A': 'von Willebrand disease (vWD)', 'B': 'Aspirin or NSAID use', 'C': 'Idiopathic thrombocytopenic purpura (ITP)', 'D': 'Glanzmann thrombasthenia', 'E': 'Bernard-Soulier syndrome'},