question: BACKGROUND: Amidst the adversities of the COVID 19 pandemic, the health care system has seen a new paradigm shift towards e-health services. In the advent of catering to the geometrically increasing health care needs of the patients suffering from various chronic health conditions when in social isolation, the need for the shift seems to be paramount. Patients with Ankylosing spondylitis under immunosuppressants and variable degrees of disabilities are at higher risk. This study aims to assess the efficacy of e-Yoga as a treatment option for these patients in need. METHODS: This is a single-center, parallel-group prospective randomized, open-blinded end-point trial. Patients aged between 30 to 50 years will be recruited from the members of Antardhwani: A society of ankylosing spondylitis, Ahmedabad, Gujarat. The yoga experts will administer a scientifically developed and validated Yoga module via e-Yoga modalities. A total of 135 patients will be recruited and randomly allocated to Yoga and control groups. Data will be recorded at baseline and three months on disease activity, degree of functional limitations in patients, quality of life, inflammatory biomarkers, depression, and anxiety using Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index(BASFI), AS Quality of Life index(ASQOL), C reactive protein (CRP), Erythrocyte sedimentation rate (ESR), Physical health questionnaire-4 (PHQ-4), respectively. DISCUSSION: The study will report the efficacy of e-Yoga in catering to the physical and mental insufficiencies of inpatients with Ankylosing spondylitis amidst Covid 19 pandemic. The study is prospectively registered in the Clinical Trial Registry of India (CTRI/2020/08/027215)