question: Q:A 72-year-old female is brought to the emergency department by ambulance because she was unable to walk. She says that she cut her leg while falling about a week ago. Since then, the wound has started draining fluid and become progressively more painful. She is found to have necrotizing fasciitis and is taken emergently to the operating room. Histological examination of cells along the fascial planes reveal cells undergoing necrosis. Which of the following represents the earliest sign that a cell has progressed to irreversible damage in this patient?? 
  {'A': 'Chromatin dissolution and disappearance', 'B': 'Condensation of DNA into a basophilic mass', 'C': 'Fragmentation of the nucleus', 'D': 'Membrane blebbing from organelles', 'E': 'Ribosomal detachment from the endoplasmic reticulum'},