question: Background: We report the results of an e-learning project focused on the progressively acquired knowledge on Coronavirus Disease 19 (COVID-19), targeted to Italian healthcare professionals. and funded by the Italian National Federation of the Associations of Doctors, Surgeons and Dentists (FNOMCeO) and the Federation of Orders of Italian Pharmacists (FOFI). Methods The core course was launched as soon as the first cases of COVID-19 occurred in Italy. Several courses have been published throughout 2020 to meet the pandemic-related educational needs and offer continuously updated and evidence-based contents, supported by evidence-based scientific information and institutional sources. Results From February 22nd to December 31st, 2020, 70,825 health professionals enrolled in the main course and 67,103 (94.7%) passed, obtaining the Continuing Medical Education (CME) credits. The participants accounted for approximately 19% and 12% of all Italian practising physicians/dentists and pharmacists, respectively. Over 99.5% of participants considered the contents of high quality, relevant and appropriate for their immediate educational needs. Conclusion The Italian e-learning offer developed in the first nine months of the pandemic achieved wide dissemination and excellent acceptance by healthcare professionals working in the field. This educational model provides healthcare professionals with evidence-based and tailored information. During pandemics it offers several advantages: time flexibility, remote participation, continuous updating following the emerging evidence.