question: I have been on Effexor xr for aproximatly 12 yrs. I have dealt with depression and anxiety since 1986. have been doing pretty good until about 2 mo s ago started feeling a lot of anger,frustration mood swings.then the most recent issue not being able to sleep waking up 2,3,4, times a night. or just insomnia. my doctor has increased my dose from 300mg daily to 450 daily. My concern is that this is too much I thought maximum dose was 375. am I wrong to beconcerned about this?