question: 67 yr old female; positive ANA Screen; Sed Rate elevated at 40; ALT 76; AST 65; ANA Titer 1:256 with mixed homogeneous, speckled and nucleolar ANA staining observed. Anti-DNA, Dbl Strand, C-Reactive Protein, Rheumatoid Factor and Hepatitis B & C all within normal ranges. 2011 CT of abdomen showed multiple scattered attenuation lesions within liver, sub-centimeter in size-likely cysts or hemangiomas. Dr. put me on plaquenil and is having an abdominal ultrasound done as well. Have great difficulty walking and climbing stairs. Is the ANA screen and sed rate related to the increased ALT and AST or am I dealing with two different things?