question: Hi doctor, I am a 55 year old male. I have been suffering from ankylosing spondylitis for at least 15 years. With very limited mobility and severe pain, I was under continuous medication and was taking Remicade (Infliximab) for the last five years. Till recently, Remicade was working well and my pain was under control, however with some limited mobility. But, in the last three months, the stiffness and pain got severe. As per my doctor's advice, I started injecting Humira - Adalimumab once in every two weeks. Four weeks since I had started using Humira now and so far injected two, but my pain and stiffness only got worse and the mobility is almost nil. My HLA B27 results are negative. My questions are, how many days or weeks I need to wait to see improvement from Humira? How long should I continue Humira even if I did not see improvement? What option I have if Humira does not work for me? Shall I try no starch diet (NSD) or low starch diet (LSD)?