question: My husband has been since last June, they did a work up and found 2 spots on his brain possible demylenation, he is now having symtoms again which are numbeness of the face and lips, headaches and his leg feels hallow all on the Left side. Today we went back he had a second MRI and it show significant increase in spots from his June MRI, they are now asking him to have a brain angio and a lumbar puncture.. Differental dx of MS or a vasculitis of the vessels in his brain? Thoughts or suggestion. When he first became sick he had speech problems, member issue, fatique and severe pain all on the left side at times he could not walk. He is on Neurontin and a few other medications. They also thought possible seizures, he is a smoker but, the MD today said, he had enough increase in spots in the brain that she is not comfortable with just saying they are ischemic changes from smoking.