question: The adverse health effects of long and short-term exposure to ambient air pollutants are well established in the epidemiological literature Amongst all pollutants, fine particulate matter (PM2 5), poses a significant mortality risk because of its toxicity and extensive human exposure During COVID-19 lockdowns, numerous studies have reported a reduction in ambient PM2 5 concentrations due to decreased anthropogenic activities Therefore, potential health benefits are plausible during this period In this pursuit, the current study aims to estimate the potential deaths that might have been avoided due to the reductions in PM2 5 levels during COVID-19 lockdowns in India's 12 states For the same, concentration–response functions are developed, and the changes in PM2 5 levels were calculated Overall, PM2 5 levels in the analysed states decreased by an average of 19 61 µg/m3 (SD = 10 34 µg/m3) during the months of April–June 2020 compared to the previous year The concentration–response coefficient (β) obtained for the Indian states is 0 02272 (0 01063–0 03481, 95% Confidence Interval) Upon using these values in the calculation, our analysis estimates that nearly 73,853–92,116 mortalities might have been avoided in the 12 analysed Indian states for the period of April–June 2020 due to the COVID-19 lockdown Given the high levels of PM2 5 in India with its well-known associated health risks and the results of this study, it is likely that the number of lives potentially saved during the COVID-19 lockdown due to reduced concentrations of PM2 5 might surpass the COVID-19 deaths in the country © 2021, Institute of Earth Environment, Chinese Academy Sciences