question: I took Accutane twice. 2 separate courses of the drug about years ago for acne. I had joint pain, fatique during the therapy and was told that was normal. Acne was so much improved it was worth it. At 59 I now have erosive arthritis. My knees were just rotten requiring total replacements. Hands, feet, elbows, even my spine are painful. I don t think I have Fibromyalsia. I got to thinking about the Accutane.