question: Good morning. I was wondering how long does bisoprolol stay in your system. about a year ago, my doctor took one blood pressure reading 140/90 and put me on bisoprolol HCTZ. Four days prior, my OB/GYN took my blood pressure 120/70. I told my primary care doctor, but he still put me on blood pressure meds despite the fact that I told him I was extremely stressed after losing my job. At any rate, I started weaning myself off the meds after taking it for 8 months July 2010-March 2011. When I exercise, I get very good readings 101/75, 99/68, 103/76 and sometimes a little higher 121/77. Prior to being placed on the meds, my blood pressure normal range was 116-120 over 70-78. Now that I ve stop the meds, if I miss a few days of not exercising my pressure is all over the place ie (151/97, 137/86, 122/83, 115/75, 140/90, etc).