question: The implementation of nature-based solutions (NBS) in urban regeneration aims to improve citizens’ health and well-being. Therefore, tools need to be applied to identify the most suitable and efficient location and type of NBS. Within the CLEVER-cities H2020 project, the Greenpass method has been chosen to evaluate different design solutions regarding thermal comfort and physiological equivalent temperature (PET), energy, water and air fluxes. The Greenpass system comprises of standardized tools, reports and a unique set of Key Performance Score (KPS) and Key Performance Indicators (KPI). This paper deals with the impact assessment of NBS by the use of the innovative Greenpass system for the CLEVER-cities project ‘Fischbeker Höfe’ in Hamburg, Germany to ensure human health and well-being improvements for the citizens. To that end and considering the climate change context, thermal comfort is a KPI with high relevance in terms of the NBS co-benefits. Based on the PET within a project area Greenpass calculates the Thermal Comfort Score (TCS). The share of the different PET classes within the project area is multiplied with a weighting factor and summarized to the TCS. The results of the climate resilience analysis of the urban development area ‘Fischbeker Höfe’ in Hamburg are presented and discussed in comparison to a conventional architecture that disregards NBS, showing improvement with regards to four out of five KPS. Based on the evaluation results, advice is given to the co-creative design team on how to further improve the design towards climate resilience. The Greenpass system has proven to be a powerful and tailored tool to support climate resilient urban design and architecture. It provides a standardized and comprehensible but still scientific basis for decisions in a highly efficient and understandable way.