question: SARS-CoV-2 infection represents an emerging public health problem with worldwide involvement since its first isolation in Wuhan, Hubei province, China in December 2019 Central nervous system and heart appear to be more affected organs beyond lungs;moreover an increasing cases of peripheral nervous system involvement associated with COVID-19 as inflammatory polyradicoloneurophaty are reported We report a case of Guillain-Barrè syndrome in a 75-year-old female associated with SARS-CoV2 infection