question: Introduction: To counteract the spread of COVID, many companies opted for teleworking and thus reduce the number of people exposed. Knowing and regulating its implications is necessary for the health of the working population. Material and Method: a prospective descriptive study was conducted from May to August 2021, through an online questionnaire, which was answered regardless of the line of work, by 202 workers in several companies in Guatemala, who were doing at least one day of teleworking. The questionnaire with 21 questions evaluated work, personal and family aspects, implications for physical and mental health;as well as economic Results: hours of workers were extended in 80%. 27% up to 3 to 4 hours outside the usual, even 83% reported work activity during weekends, 88% having message / call activities outside the regular hours. Around 40% did not have a suitable table and chair for teleworking, which led to 96% reporting at least some physical symptoms, such as neck pain, eye fatigue and back pain. Conclusions: half of the respondents indicated that they were prepared to telecommute, but the same number reported personal life problems with noise, lighting, and temperature, which led to eating and sleeping disorders, and physical conditions. Workers had increases electricity and internet expenses, making 50% of the participants an investment of $50. Although, 81% indicated they agree that teleworking be implemented, 96% consider that it should be regulated.