question: I have been suffering from severe depression with severe anhedonia for four years.  Seen a number psychiatrists, been prescribed numerous medications with no success.  I alsoave 20-30 tiny white matter lesions.  My neurologist called them smokers plaques and didn't seem particularly concerned about them.  I am afraid that I have vascular depression with no hope of recovery.  I am only 55.  Used to  be an attorney, now I am virtually bedridden.  If you do think that I have vascular depression, any treatment suggestions as to treatment?  I am in psychological agony!