question: Yes, I have a friend who has been taking ibuprophen for joint pain for a couple of years. He has recently developed a swelling in both hands which causes painful movement and actually gets pain up both arms into the shoulders. It is continuing to get worse and the VA doctors have so far been unable to put a finger on what it going on. He is around 50, was in great shape until about a year ago. Used to run 5 miles every day, now walks it.