question: Past research has found that a perceived meaning in life can act as a protective factor against adverse mental health symptomology, while also providing coping resources to buffer against the impact of negative life events. The current research investigated how the impact of self-perceived meaning in life as well as its predictors interact with stressors and worry related to the COVID-19 pandemic. We collected survey based data (n = 260) from Australian participants during the pandemic, measuring their meaning in life, orientation to differing life goals and COVID-19 related stressors via the impact of events scale. We found that meaning in life predicted less stress and worry associated with COVID-19. We also found that intrinsic based aspirations related positively to meaning in life within this context whereas extrinsic based goals related negatively to it, although these aspirations were not significant in reducing the stressors associated with COVID-19. These results reinforce past findings that meaning in life can effectively buffer against the impact of negative life events such as the COVID-19 pandemic. They also suggest that intrinsic based aspirations centred on relationships and self-acceptance may be an important mechanism in how people choose to pursue life meaning during uncertain life events.