question: • As the number of patients with COVID-19 is increasing worldwide, it is necessary to stress on the importance of the atypical clinical presentations (including those related to the nervous system) of COVID-19 infection, since they might be the initial manifestations. • Literature on this regard should be sent by the international and local health committees to all health-care providers during this COVID -19 pandemic, to make sure that all providers are well informed and aware of these cases. • More studies are deeply needed to enable the concerned committees to make evidence-based guidelines for prevention, early detection and appropriate management of these cases.