question: Objective This study was conducted to evaluate the effect of medium chain triglycerides (MCT) with organic acids (OA) on growth performance, fecal score, blood profiles, intestinal morphology, and nutrient digestibility in weaning pigs. Methods A total of 120 weaning pigs ([Yorkshire x Landrace]) x Duroc) with an average body weight (BW) of 8.00 ± 0.87 kg were assigned in five treatments considering sex and initial BW in 3 replications with 8 pigs per pen in randomized complete block design. The experimental diets included a corn-soybean meal based basal diet with or without 0.1% or 0.2% MCT and 0.1% OA. The pigs were fed the diets for 5 weeks (phase 1: 0-2 weeks, phase 2: 3-5 weeks). A total of 15 barrows with an average BW of 12.48 ± 0.37 kg were used to evaluate the nutrient digestibility by total collection method. The BW and feed intake were measured at the end of each phase. Blood samples and small intestine samples were collected at the end of each phase. Results Supplementing 0.1% MCT with 0.1% OA showed greater BW for week 5 and ADG for overall period than control diet. Supplementing 0.1% MCT increased (p<0.05) ADG and improved (p<0.05) G:F ratio for phase 1. Dietary MCT and OA did not affect the fecal score and blood concentration of cortisol, IgG, TNF-α, IL-1β, IL-6, and IL-10 in weaning pigs. Pigs fed the diets with 0.1% MCT had greater (p<0.05) villus height of duodenum and ileum for phase 1. Also, pigs fed the diet with 0.1% OA showed greater (p<0.05) villus height and villus height to crypt depth ratio of duodenum for phase 2. There was no significant difference in nutrient digestibility and nitrogen retention of pigs. Conclusion Addition of 0.1% MCT with 0.1% OA in weaning pig's diet improved growth performance partly by enhancing intestinal morphology in weaning pigs.