question: Q:A 2-month-old boy is brought to the physician by his mother because of poor weight gain and irritability since delivery. He is at the 10th percentile for height and below the 5th percentile for weight. Physical examination shows conjunctival pallor. Laboratory studies show:
  Hemoglobin 11.2 g/dL
  Mean corpuscular hemoglobin 24.2 pg/cell
  Mean corpuscular volume 108 μm3
  Serum
  Ammonia 26 μmol/L (N=11–35 μmol/L)
  A peripheral blood smear shows macrocytosis of erythrocytes and hypersegmented neutrophils. Supplementation with folate and cobalamin is begun. Two months later, his hemoglobin concentration is 11.1 g/dL and mean corpuscular volume is 107 μm3. The patient's condition is most likely caused by failure of which of the following enzymatic reactions?"? 
  {'A': 'Ornithine and carbamoylphosphate to citrulline', 'B': 'Glucose-6-phosphate to 6-phosphogluconate', 'C': 'Hypoxanthine to inosine monophosphate', 'D': 'Phosphoenolpyruvate to pyruvate', 'E': "Orotate to uridine 5'-monophosphate"},