Ever thought about a gender reassignment where you substitued male for female characteristics or the opposite?
I haven't for myself, but I know people who have been in that situation.  I'm all for it.
Did your friend do hormone therapy?
He did, yeah.  Still going through it.  He was born a biological female, and for the longest time thought he was just a lesbian.  But something wasn't quite right still.  Admirable person.
Sex reassignment therapy
Sex reassignment therapy is the medical aspect of gender transitioning, that is, modifying one's characteristics to better suit one's gender identity. It can consist of hormone therapy to modify secondary sex characteristics, sex reassignment surgery to alter primary sex characteristics, and other procedures altering appearance, including permanent hair removal for trans women.
In appropriately evaluated cases of severe gender dysphoria, sex reassignment therapy is often the best when standards of care are followed. There is academic concern over the low quality of the evidence
people born with physical sex characteristics "that do not fit typical binary notions of male or female bodies". The opposite of "transgender" is "cisgender", which describes persons whose gender identity or expression matches their assigned sex.
The degree to which individuals feel genuine, authentic, and comfortable within their external appearance and accept their genuine identity has been called "transgender congruence". Many transgender people experience gender dysphoria, and some seek medical treatments such as hormone replacement therapy, sex reassignment surgery, or psychotherapy.