i work as a stand up comedian. Nothing is more rewarding than to performs in front of a live audience, usually speaking directly to them.
That's great, I was wondering if there is anything in the brain that helps with comedy?
It has nothing to do with the brain. All you have to do is to  recite a grouping of humorous stories, jokes and one-liners typically called a monologue, routine or act.
That's great, does one have to learn a special skill to become a professional comedian?
and crucial for the comedian's act. Audiences expect a stand-up comedian to provide four to six laughs per minute, and a performer is always under pressure to deliver, especially the first two minutes.
Stand-up comedy show Basic format.
A stand-up comedy show is rarely one comedian. It is usually a multi-person, showcase format, often with a traditional opener, feature performer, and headliner. A traditional format typically features an opening act known as a host, "compère" (
Stand-up comedy
Stand-up comedy is a comic style in which a comedian performs in front of a live audience, usually speaking directly to them. The performer is commonly known as a comic, stand-up comic, comedian, comedienne, stand-up comedian, or simply a stand-up. In stand-up comedy, the comedian gives the illusion that they are dialoguing, but in actuality, they are monologuing a grouping of humorous stories, jokes and one-liners, typically called a shtick