text: It's very very difficult to lose weight while taking prednisone, and even after you stop taking it, you might find the pounds hard to lose. \n\nThat said, I've been on prednisone many times over the years, and gained a LOT of weight from it. I'm still taking pred, actually, am on a maintenance dose of 5mg/day, and have been on it non-stop for about 5 years now. (I was started at 60mg/day and slowly tapered down.)  Once I was tapered down to 10mg/day, I was able to start losing weight with the South Beach Diet. It's a very sensible diet, high in complex carbs (veggies, fruits, whole grains) and proteins. Combine it with exercise for best results. In just over 2 years, I've lost about 60 pounds.