text: intrinsic resistance when talking about bacteria is the ability of bacteria to be resistant to something(usually antibiotics) because of the makeup or special feature of the bacteria..somthing that the bacteria had when it originated.  Like the ability of a certain bacteria to produce betalactamases which are enzymes produced by certain bacteria to inactivate beta lactam antibiotics..this bacteria has an intrinsic factor that allows it to produce this enzyme and therefore be resistant