text: Tunnels of Blood by Darren Shan (Chapter Two to be more precise) provides an answer to your question.\n\n-a stake through the heart\n-a well-placed bullet\n-fire\n-a falling heavy object will kill a vampire. They are harder to kill than humans but they are not immortal.\nIt is also included in this book that crosses, garlic or holy water don't matter to vampires.