text: your body should get used to the glucophage within 2 weeks, and you'll be okay. believe me, it's much better than having to have insulin injections like i do!! i'm constantly bruised, and the insulin burns like hell...it doesn't matter how warm/cold it is, or how slow i inject it...it always burns like mad. \nyou must have pretty high blood glucose levels if you're taking 500mg 3 x's a day...if you stop taking it, you could have a stroke due to your sugars going way too high. \nyou could talk to your doctor about other meds such as, glipizide, actos, avandia, metformin, etc. best of luck with this.