text: I have been a pump user since 1995 and have used all the above.  I favor the silhouette infusion set personally because it lies more flush against the skin and doesn't catch and possibly snag on clothing like the quick release.  Also, I don't particularly care for the use of poly-skin dressing as it tends to irritate the skin.  The silhouette can be quickly released, leaving only the infusion set flush against the skin surface and they come with stopper clips for bathing, but aren't really necessary.  I would cleanse it with an alcohol swab anyway for sterilization though.\nBest of luck and I hope your choice works best for you...it's really a matter of personal preference really.\nBTW, you may find more information on these items at www.minimed.com   Also, the new 722 is awesome as it has a bolus wizard and is compatible with the Guardian Real Time continuous glucose monitor. It communicates glucose readings directly with your pump and alarms when your glucose levels are too high or too low.  There is good information on this at the mini med website.  Again, much luck to you...live long and live healthy.