text: The Krebs cycle occurs in the mitochondrial matrix. Pyruvate produced in the glycolysis is first decarboxylated to yield acetyl-CoA. The acetyl-CoA combines with oxaloacetate to yield citrate. Citrate is then converted to isocitrate. Isocitrate is then converted to a-ketoglutarate (first CO2 is lost and the first NADH is produced). A-keto is converted to succinyl-CoA (CO2 produced). At this point the rest of the cycle is to regenerate oxaloacetate. The succinyl-CoA is converted to succinate (producing GTP) which is converted to fumarate (produces FADH2). Fumarate is converted to Malate and finally to Oxaloacetate (NADH produced). Krebs cycle produces a total of 1 GTP, 1 FADH2 and 3 NADH. The FADH2 and NADH enter the electron transport chain. For each molecule of glucose there will be 2 turns of the cycle.