text: A chromosome mutation is a change that involves a part of, or an entire chromosome: examples: non-homologous translocations,\nadditions or deletions caused by chromosomal breakage and reattachment, inversions, nondisjunction, polyploidy, to name a few .\n\nA gene mutation involves a change in DNA, like mis- pairing of the N-bases .This is considered a biochemical change.\n\nThere are specific genetic disorders in humans associated with either chromosome or gene mutations.