text: The answer lies in the mechanism of action of the two medications.  \n\nAtomoxetine (Strattera) is a norepinephrine re-uptake inhibitor inhibitor that acts almost exclusively on the noradrenergic pathway.\n\nBupropion (Wellbutrin) inhibits the re-uptake of norepinephrine and dopamine neurotransmission without any significant direct effects on serotonin neurotransmission.\n\nSo as you can see the medications act on similiar mechanism and therefore taking them both would be like overdosing on either.  Wellbutrin can also promote seizure which is dose related too.\n\nIn sum, taking them together could be dangerous.