text: The final STQ-77/FET framework classifies temperament traits and their neurochemical biomarkers into 12 components: nine components regulating the formal functional aspects of behaviour (energetic, dynamic and orientational) each assessed in three domains (intellectual, physical and social-verbal); also three components related to emotionality (Neuroticism, Impulsivity and Satisfaction (Self-Confidence)) (see Figure) 
  The FET framework summarized existing literature showing the nine non-emotionality traits are regulated by the monoamines (MA) (noradrenalin, dopamine, serotonin), acetylcholine and neuropeptide systems, whereas the three emotionality-related traits emerge as a dysregulation of opioid receptors systems that have direct control over MA systems. Importantly, the FET model suggests that there is no one-to-one correspondence between the neurotransmitter systems underlying temperament traits (or mental disorders) but instead specific ensemble relationships between these systems emerge as temperament traits. The FET framework is based only on the strongest consensus points in the research studying the role of neurotransmitter in behavioural regulation and the components of temperament; it doesn't list more controversial links between these multiple systems.
   Neurotransmitter systems: 5-HT: serotonin; DA: dopamine; NE: noradrenalin; ACh: acetylcholine; Glu: glutamate; OXY: oxytocin; VSP: vasopressin; NP: Neuropeptides; KOR, MOR, DOR: kappa-, mu- and delta-opioid receptors correspondingly; sANS - sympathetic autonomic nervous system; HPA - hypothalamic–pituitary–adrenal axis.
  The FET points out that opioid receptor systems are involved not only in regulation of emotional dispositions but also amplify three non-emotionality aspects of behaviour (KOR for orientation, DOR for integration of actions and MOR of approval-maintenance of behaviour). This involvement was confirmed for MOR systems that bind endorphins: experiments show that MOR overstimulation influences hypothalamic serotonin and Brain-derived neurotrophic factor release and affecting endurance aspects of behaviour. The interplay within hormonal systems and its interaction with serotonin also appeared to be a factor is social emotions, such as shame and guilt