text: The complexity of interactions in the human immune system has prompted the generation of a wealth of immunology-related multi-scale omic data.  Multi-omic data analysis has been employed to gather novel insights about the immune response to infectious diseases, such as pediatric chikungunya, as well as noncommunicable autoimmune diseases. Integrative omics has also been employed strongly to understand effectiveness and side effects of vaccines, a field called systems vaccinology.  For example, multiomics was essential to uncover the association of changes in plasma metabolites and immune system transcriptome on response to vaccination against herpes zoster.