text: Dynamic kinetic resolution has also been applied to the total synthesis of a variety of natural products.  After Bäckvall's discoveries in 2007, he employed another enzyme-metal coupled reaction to synthesize the natural product (R)-Bufuralol.
  The key step that the literature points out utilizes DKR to convert the chlorohydrin into the (S)-acetate by means of a lipase and a ruthenium catalyst.
  The lipase PS-C “Amano” II has been reported in the literature to be particularly enantioselective for the 1-phenyl-2-chloroethanol motif.  The enzyme, along with the ruthenium catalyst, allows for rapid racemization of the chlorohydrin with a selective binding to the (S) isomer for the acetylation reaction.  Here isopropenyl acetate is used as the acyl donor.  The product is achieved in excellent yield (96%) and near-perfect enantiomeric excess (>99%).