text: Every two anomers are designated alpha (α) or beta (β), according to the configurational relationship between the anomeric centre and the anomeric reference atom, hence they are relative stereodescriptors. The anomeric centre in hemiacetals is the anomeric carbon C-1; in hemiketals, it is the carbon derived from the carbonyl of the ketone (e.g. C-2 in -fructose). In aldohexoses the anomeric reference atom is the stereocenter that is farthest from anomeric carbon in the ring (the configurational atom, defining the sugar as  or ). For example, in α--glucopyranose the reference atom is C-5.
  If in the cyclic Fischer projection the exocyclic oxygen atom at the anomeric centre is cis (on the same side) to the exocyclic oxygen attached to the anomeric reference atom (in the OH group) the anomer is α. If the two oxygens are trans (on different sides) the anomer is β. Thus, the absolute configurations of the anomeric carbon and the reference atom are the same (both R or both S) in the α anomer and opposite (one R and the other S) in the β anomer.