text: 1,1,1-Trichloroethane was one of the volatile organochlorides that have been tried as alternatives to chloroform in anaesthesia.
  In the 1880s, it was found to be a safe and strong substitute for chloroform but its production was expensive and difficult.
  In 1880, 1,1,1-Trichloroethane was suggested as an anaesthetic. It was first referred to as "methyl-chloroform" in the same year. At the time, the narcotic effects of chloral hydrate were owed to a hypothetical metabolic pathway to chloroform in "alkaline blood". Trichloroethane was studied for its structural similarity to chloral and potential anaesthetic effects. However, trichloroethane did not exhibit any conversion to chloroform in laboratory experiments. The 1,1,2-trichloroethane isomer, which lacked a trichloromethyl group, exhibited anaesthetic effects even stronger than the 1,1,1 isomer.