text: Target 2035 is a global effort or movement to discover open science, pharmacological modulator(s) for every protein in the human proteome by the year 2035.  The effort is led by the Structural Genomics Consortium with the intention that this movement evolves organically. Target 2035 has been borne out of the success that chemical probes have had in elevating or de-prioritizing the therapeutic potential of protein targets. The availability of open access pharmacological tools is a largely unmet aspect of drug discovery especially for the dark proteome. 
  The first five years will include building mechanisms (Phase 1 below) which allow researchers to find collaborators with like-minded goals towards discovering a pharmacological tool for a specific protein or protein family, and make it open access (without encumbrances due to intellectual property). One strategic goal is seeding new open science programs on components of the drug discovery pipeline with the goal to bring medicines to the bedside equitably, affordably and rapidly. Phase 1 will also build a framework that welcomes new and (re-)emerging enabling technologies in hit-finding and characterization. An update on the progress was published.
  Target 2035 will draw on successes from past and current publicly-funded programs including National Institutes of Health (NIH) [https://druggablegenome.net/index Illuminating the Druggable Genome initiative] for under-explored kinases, GPCR’s and ion channels, Innovative Medicines Initiatives [https://re-solute.eu/ RESOLUTE] project on human SLCs, Innovative Medicines Initiatives [https://www.eubopen.org/ Enabling and Unlocking Biology in the Open] (EUbOPEN), and Innovative Medicines Initiative's [https://ultra-dd.org/ Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery]. The NIH recently re-iterated their commitment to making their data open to mitigate the tens of billions due to irreproducible data. 
  Target 2035 will collaborate with the Chemical Probes Portal and open science platforms, e.g. [https://app.jogl.io/space/target2035 Just One Giant Lab], in order to spread awareness and education of best practices for chemical modulators and the benefits of open science, respectively.
  The following draft plan has been outlined in a white paper.