text: Immunotherapy is a treatment used to produce immunity to a disease or enhance the resistance of the immune system to an active disease process, such as cancer
  Wnt and Fz genes are frequently overexpressed in head and neck squamous cell carcinoma (HNSCC).  Treatment of a HNSCC cell line (SNU 1076) with anti-Wnt1 antibodies reduced the activity of the Wnt/Fz dependent transcription factor LEF/TCF and diminished the expression of cyclin D1 and B-catenin proteins.  Similar to anti-Wnt antibodies, treatment with recombinant SFRP1 inhibited growth of SNU 1076 cells as well.  This suggests that Wnt and Fz receptors may be attractive targets for immunotherapy and drug therapy of HNSCC.