text: The operon consists of the promoter region fim S, the main constituent fim A, its gene product forming a rod like structure and fim H, coding for an adhesin at the tip, to name just a few important elements. The fim S region is flanked by 9bp repeats that are mirror images of each other. These mirror images serve as substrates for two ATP-dependent recombinases, fim B and fim E. These recombinases can invert the orientation of the  fim S region and only one orientation allows for 3 to 5 transcription.
  fim B "flips" the promoter region both ways, from the "on" position to the "off" position and vice versa, whereas fim E can only facilitate recombination from "on" to "off". This equilibrium, shifted towards maintaining the "off" position, due to higher fim E activity, serves as a mode of expressing pili only when adhesion is needed. Another level of transcriptional control in E. coli is mediated by the sensitivity of the recombinases to pH and osmolarity, further ensuring appropriate expression levels of type-I pili, given the stark differences in osmolarity inside and outside an animals body. Type-I pili are expressed by many species of Enterobacteriaceae. The transcriptional control can differ widely between species, in Salmonella typhimurium, for example much influence is exerted by a leucine-responsive regulatory protein and there is no fim' S element.