text: Disruption of TAD boundaries can affect the expression of nearby genes, and this can cause disease.
  For example, genomic structural variants that disrupt TAD boundaries have been reported to cause developmental disorders such as human limb malformations. Additionally, several studies have provided evidence that the disruption or rearrangement of TAD boundaries can provide growth advantages to certain cancers, such as T-cell acute lymphoblastic leukemia (T-ALL), gliomas, and lung cancer.