text: RopB regulation speB is a key determinant in the expression of the speB proteinase which is a primary virulence factor and the most abundant extracellular protein in Streptococcal secretions. SpeB cleaves host serum proteins that make up the human extracellular matrix and bacterial proteins including other secreted Streptococcal proteins. As previously mentioned, it is responsible for the dissemination of a host of infectious diseases including but not limited to pharyngitis, impetigo, streptococcal toxic shock syndrome, necrotizing fasciitis, and scarlet fever. Therefore, study of the inactivation of speB's many functional pathways and regulators are of critical importance in developing potential novel therapeutics.