text: Though it was initially dubbed "mysterious protein", recent empirical studies are gradually starting to unveil some of seipins most compelling physiological functions. Among these, the following have been identified: central regulation of energy homeostasis, lipid catabolism (essential for adipocyte differentiation), lipid storage and lipid droplet maintenance, as well as prevention of ectopic lipid droplet formation in non-adipose tissues. Additionally, mutations of BSCL2 have been recently linked to the Silver syndrome (hereditary spastic periplegia type 17) and Celias encephalopathy.