text: Assuming that catalytic activity largely depends on the catalyst's affinity to the transition state, one could synthesize a transition state analog (TSA), a structure that resembles the transition state of the reaction. Then one could link the TSA to a solid-support or identifiable tag and use that TSA to select an optimal catalyst from a mixture of many different potential catalysts generated chemically or biologically by a diversity oriented synthesis. This method allows quick screening of a library of diverse compounds. It does not require as much synthetic effort and it allows a study of various catalytic factors simultaneously. Hence the method could potentially yield an efficient catalyst that we could not have designed with our current knowledge.
  Many catalytic antibodies were developed and studied using this approach.