text: Since its original description in 1992, the CSI method has been used to characterize the secondary structure of thousands of peptides and proteins.  Its popularity is largely due to the fact that it is easy to understand and can be implemented without the need for specialized computer programs.  Even though the CSI method can be easily performed manually, a number of commonly used NMR data processing programs such as NMRView, NMR structure generation web servers such as [http://www.cs23d.ca/ CS23D] as well as various NMR data analysis web servers such as [http://randomcoilindex.com RCI], [http://www.preditor.ca/ Preditor] and PANAV  have incorporated the CSI method into their software.