text: According to Ostwald's rule, usually less stable polymorphs crystallize before the stable form.  The concept hinges on the idea that unstable polymorphs more closely resemble the state in solution, and thus are kinetically advantaged.  The founding case of fibrous vs rhombic  benzamide illustrates the case. Another example is provided by two polymorphs of titanium dioxide. Nevertheless, there are known systems, such as metacetamol, where only narrow cooling rate favors obtaining metastable form II.
  Polymorphs have disparate stabilities.  Some convert rapidly at room (or any) temperature. Most polymorphs of organic molecules only differ by a few kJ/mol in lattice energy. Approximately 50% of known polymorph pairs differ by less than 2 kJ/mol and stability differences of more than 10 kJ/mol are rare. Valuable to mention that polymorph stability may change upon temperature or pressure. Important to note that structural and thermodybnamic stability are different. Thermodynamic stability may be studied using experimental or computational methods.
  Polymorphism is affected by the details of crystallisation. The solvent in all respects affects the nature of the polymorph, including concentration, other components of the solvent, i.e., species that inhibiting or promote certain growth patterns. A decisive factor is often the temperature of the solvent from which crystallisation is carried out.
  Metastable polymorphs are not always reproducibly obtained, leading to cases of "disappearing polymorphs", with usually negative implications on law and business.