text: This snail has been studied in relation to human pathology and the epidemiology of schistosomiasis.  S. masoni is known to change its host’s (B. glabrata's) behavior via the upregulation/downregulation of neuropeptides such as schistosomin and NPY, and some studies have reported that FMRFamide is aminergic, and may be implicated in the secretion of molecules to respond to infection with parasites.
  The ganglionic central nervous system (CNS) of B. glabrata consists of paired cerebral, pedal, pleural, parietal, and buccal ganglia, and one unpaired visceral ganglion. FMRFamide is concentrated in the concentrated in the cerebral and visceral ganglia, although evidence from current research suggests that FMRFamide moves downward of the head-foot region of the snail as embryonic development proceeds.
  The exact role of FMRFamide during early development of the embryonic central nervous system is not well studied. Detection of this neuropeptide is important because its expression lays down the foundation of the CNS in the early stages of development in invertebrates. In recent years, neuromodulatory actions of FMRFamide in invertebrates have become more apparent. This is in part due to the extensive studies done on the Planorbidae and Lymnaeidae families of pond snails.
  FMRFamide expression in B. glabrata can be detected as early 72 hours, post-cleavage.  Studies have shown its expression pattern in the posterior of the ganglionic nervous system, as the first FMRFamide immunoreactive cell appears at 25-28% of development and is located at the extreme posterior of the embryo. The cell sends a single process on each side and each process follows the body curvature.
  As these processes elongate, two lateral FMRFamide-expressing cells are apparent on either side of the body wall. Some studies have suggested that FMRFamide these structures may innervate muscles that originate in trochopore larvae and expand during development. This neuromodulator helps to regulate cardiac activity. Several FMRFamid related peptides are known, regulating various cellular functions and possessing pharmacological actions, such as anti-opiate effects. FMRFamide may also play a role in osmoregulation and developmental patterning. This neuropeoptide has multiple functions and controls many processes that allow the embryo to mature into an adult snail.