text: Other than standard fluorescence optical tweezers are now being built with multiple color Confocal, Widefield, STED, FRET, TIRF or IRM.
  This allows applications such as measuring: protein/DNA localization binding, protein folding, condensation, motor protein force generation, visualization of cytoskeletal filaments and motor dynamics, microtubule dynamics, manipulating liquid droplet (rheology) or fusion. These setups are difficult to build and traditionally are found in non correlated academic setups. In the recent years even home builders (both biophysics and general biologists) are converting to the alternative and are acquiring total correlated solution with easy data acquisition and data analysis.