text: One of the challenges of DNA computing is its speed. While DNA as a substrate is biologically compatible i.e. it can be used at places where silicon technology cannot, its computation speed is still very slow. For example, the square-root circuit used as a benchmark in field took over 100 hours to complete. While newer ways with external enzyme sources are reporting faster and more compact circuits, Chatterjee et al. demonstrated an interesting idea in the field to speed up computation through localized DNA circuits,  a concept being further explored by other groups. This idea, while originally proposed in the field of computer architecture, has been adopted in this field as well. In computer architecture, it is very well-known that if the instructions are executed in sequence, having them loaded in the cache will inevitably lead to fast performance, also called the principle of localization. This is because with instructions in fast cache memory, there is no need swap them in and out of main memory, which can be slow. Similarly, in [https://www.nature.com/articles/nnano.2017.127 localized DNA computing], the DNA strands responsible for computation are fixed on a breadboard-like substrate ensuring physical proximity of the computing gates. Such localized DNA computing techniques have shown to potentially reduce the computation time by [https://www.nature.com/articles/nnano.2017.127 orders of magnitude].