text: Hyperglycemia, a side effect caused by diabetes, combines with oxidative stress to create advanced glycation end-products (AGEs) that can lead to diabetic retinopathy (RD) and cause symptoms such as blindness in adults.
  The manipulation of the glyoxalase system in mice retina has shown there is a potential for targeting the glyoxalase system to use as a therapeutic treatment for RD by lowering the production of AGEs.
  Oxidative stress can lead to worsening neurological diseases such as Alzheimers, Parkinsons, and Autism Spectrum Disorder. Flavonoids, a type of antioxidant that combats oxidative stress in the body, has been found to help decrease the production of radical oxygen species (ROS) mostly by preventing the formation of free radicals but also partially by promoting the glyoxalase pathway via increasing transcription of GSH and GSH constituent subunits to increase intracellular levels of GSH.