text: The detection of -2-hydroxyglutarate in glioma patients using proton magnetic resonance spectroscopy (MRS) has been shown to be a noninvasive procedure. The presence of IDH1 or IDH2 mutations was linked to the detection of this oncometabolite 100 percent of the time. IDH2/R140Q is a specific mutation that has shown promising results after its inhibition by the small molecule AGI-6780. Therefore, limiting the supply of -2-hydroxyglutarate by inhibiting the detected mutant IDH enzymes could be a good therapeutical approach to IDH-mutant cancers.