text: Under pre-equilibrium conditions, the catalyst and substrate undergo rapid and reversible association prior to a relatively slow step leading to product formation and release. Under these conditions, the system can be described by a "one-plus" rate law where the numerator consists of all rate constants and species required to go from starting material to product, and the denominator consists of a sum of terms describing each of the states in which the catalyst exists (and 1 corresponds to the free catalyst). For the simplest case where one substrate goes to one product through a single intermediate:
  In the slightly more complex situation where two substrates bind in sequence followed by product release:
  In the case of the simple pre-equilibrium conditions described above, the catalyst resting state is either entirely or partially (depending on the magnitude of the equilibrium constant) the substrate bound complex.