text: Beyond its canonical role in the SIR complex, SIR2 also plays a role in rDNA repression. As part of the cells regulation mechanism, rDNA repeats are excised from the chromosome so they cannot be expressed. SIR2 forms a complex with NET1 (a nuclear protein) and CDC14 (a phosphatase) to form the regulator of nucleolar silencing and telophase (RENT) complex. The RENT complex sequesters excised rDNA in extrachromosomal circles, preventing recombination. Accumulation of these circles has been linked to premature aging. Sirtuin 2 (SIRT2), SIR2s human analog, has also been linked to age-related disease.