text: Since directing groups are ligands, their effectiveness correlates with their affinities for metals. Common functional groups such as ketones usually are only weak ligands and thus often are poor DGs.  This problem is solved by the use of a transient directing group. Transient DGs reversibly convert weak DGs (e.g., ketones) into strong DG's (e.g., imines) via a Schiff base condensation.  Subsequent to serving their role as DGs, the imine can hydrolyze, regenerating the ketone and amine.