text: Asymmetric induction by the molecular framework of an acyclic substrate is the idea that asymmetric steric and electronic properties of a molecule may determine the chirality of subsequent chemical reactions on that molecule. This principal is used to design chemical syntheses where one stereocentre is in place and additional stereocentres are required.
  When considering how two functional groups or species react, the precise 3D configurations of the chemical entities involved will determine how they may approach one another. Any restrictions as to how these species may approach each other will determine the configuration of the product of the reaction. In the case of asymmetric induction, we are considering the effects of one asymmetric centre on a molecule on the reactivity of other functional groups on that molecule. The closer together these two sites are, the larger an influence is expected to be observed. A more holistic approach to evaluating these factors is by computational modelling, however, simple qualitative factors may also be used to explain the predominant trends seen for some synthetic steps. The ease and accuracy of this qualitative approach means it is more commonly applied in synthesis and substrate design. Examples of appropriate molecular frameworks are alpha chiral aldehydes and the use of chiral auxiliaries.