text: Several important anticancer agents both bind to DNA and generate reactive oxygen species.  These include adriamycin and other anthracyclines,  bleomycin, and cisplatin.  These agents may show specific toxicity towards cancer cells because of the low level of antioxidant defenses found in tumors. Recent research demonstrates that redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells that can be selectively targeted by pro-oxidant non-genotoxic redox chemotherapeutics.
  Photodynamic therapy is used to treat some cancers as well as other conditions. It involves the administration of a photosensitizer followed by exposing the target to appropriate wavelengths of light. The light excites the photosensitizer, causing it to generate reactive oxygen species, which can damage or destroy diseased or unwanted tissue.