text: In addition to BLOSUM matrices, a previously developed scoring matrix can be used. This is known as a PAM. The two result in the same scoring outcome, but use differing methodologies. BLOSUM looks directly at mutations in motifs of related sequences while PAM's extrapolate evolutionary information based on closely related sequences.
  Since both PAM and BLOSUM are different methods for showing the same scoring information, the two can be compared but due to the very different method of obtaining this score, a PAM100 does not equal a BLOSUM100.