text: As the equation originated with Henri, not with Michaelis and Menten, it is more accurate to call it the Henri–Michaelis–Menten equation, though it was Michaelis and Menten who realized that analysing reactions in terms of initial rates would be simpler, and as a result more productive, than analysing the time course of reaction, as Henri had attempted. Although Henri derived the equation he made no attempt to apply it. In addition, Michaelis and Menten understood the need for buffers to control the pH, but Henri did not.