text: A thiophosphonate group is a functional group related to phosphonate by substitution of an oxygen atom for a sulphur. They are a reactive component of many pesticides and nerve agents. Substituted thiophosphonates can have 2 main structural isomers bonding though either O or S groups to give thione and thiol forms respectively. This is a property they share with related functional groups such as thiocarboxylic acids and organothiophosphates.