text: Mutations in the HNF4A gene have been linked to maturity onset diabetes of the young 1 (MODY1).
  This seems to be caused by HNF4-a's [http://jme.endocrinology-journals.org/content/43/1/19.full.pdf] role in the synthesis of SHBG, which is known to be severely diminished in patients with insulin-resistance.