text: The final part dealt with the construction of oxetane ring D starting with protection of the alcohol group in  38 (Scheme 4). as a TROC alcohol 39 with  2,2,2-trichloroethyl chloroformate and pyridine. The OBOM group was replaced by a bromine group in three steps: deprotection to 40 with hydrochloric acid and sodium iodide, mesylation to 41 with mesyl chloride, DMAP and pyridine and nucleophilic substitution with inversion of configuration with lithium bromide to bromide 42. Because the oxidation of the alkene group to the diol 43 with osmium tetroxide was accompanied by the undesired migration of the benzoate group, this step was taken to completion with imidazole as 44. Two additional countermeasures were required: reprotection of the diol as the carbonate ester 45 with triphosgene and removal of the benzoate group (KCN) to alcohol 46 in preparation of the actual ring closure to the oxetane 47 with N,N-diisopropylethylamine. In the final steps the tertiary alcohol was acylated in 48, the TIPS group removed in 49 and the benzoate group re-introduced in 50.
  Tail addition of the Ojima lactam 51 was not disclosed in detail but finally  taxol 52 was formed in several steps similar to the other efforts.