text: An important application of mass spectrometric immunoassy is that it can be used as a rapid, sensitive and accurate screening of apolipoproteins and mutations of them. Apolipoproteins represent a groups of proteins with many functions such as transport and clearance as well as enzyme activation. Recent studies have claimed that mutations in apopliproteins result in, or assist in the progression of various associated diseases including amyloidosis, amyloid cardiomyopathy, Alzheimer's disease, hypertriglyceridemic, lowered cholesterol, hyperlipidemia and atherosclerosis to name a few. Nelson and colleagues did a study using MSIA to characterize and isolate apolipoproteins species.