text: Rett syndrome is a neurodevelopmental disorder involving deterioration of learned language and motor skills, autism, and seizures starting in infancy. Many cases of Rett syndrome are associated with mutations in MECP2, a gene encoding a transcriptional repressor. Mutations in this gene decrease the levels of MeCP2 binding to different promoter sequences, resulting in their overall derepression. The increased expression of these MeCP2 regulated genes in neurons contribute to the Rett syndrome phenotype.