text: LASiS has some limitations in the size control of NMNp, which can be overcome by laser treatments of NMNp. Other cons of LASiS include: the slow rate of NPs production, high consumption of energy, laser equipment cost, and decreased ablation efficiency with longer usage of the laser within a session.  Other pros of LASiS include: minimal waste production, minimal manual operation, and refined size control of nanoparticles.