text: In addition to diagnosis and classification, EPIC-seq holds promise in predicting patient response to various cancer therapies, including immune-checkpoint inhibition (ICI). By analyzing changes in gene expression patterns captured through EPIC-seq, researchers can forecast patient response to PD-(L)1 blockade therapy, which can provide great help in personalized cancer treatment. EPIC-seq-derived indices have shown significant correlation with treatment response, offering potential prognostic markers for therapy outcome prediction.