text: Surprisal analysis was extended to better characterize and understand cellular processes, see figure, biological phenomena and human disease with reference to personalized diagnostics. Surprisal analysis was first utilized to identify genes implicated in the balance state of cells in vitro; the genes mostly present in the balance state were genes directly responsible for the maintenance of cellular homeostasis. Similarly, it has been used to discern two distinct phenotypes during the EMT of cancer cells.