text: A well studied pioneer factor family is the Groucho-related (Gro/TLE/Grg) transcription factors that often have a negative effect on transcription.  These chromatin binding domains can span up to 3-4 nucleosomes.  These large domains are scaffolds for further protein interactions and also modify the chromatin for other pioneer factors such as FoxA1 which has been shown to bind to Grg3.  Transcription factors with zinc finger DNA binding domains, such as the GATA family and glucocorticoid receptor.  The zinc finger domains do not appear to bind nucleosomes well and can be displaced by FOX factors. 
  In the skin epidermis, SOX family transcription factor, SOX9, also behaves as a pioneer factor that governs hair follicle cell fate and can reprogram epidermal stem cells to a hair follicle fate.