text: In general, EPIC-seq analysis results showed a significant correlation between the inspected biological effect and the developed score. For the classification tasks Area Under the ROC (receiver operating characteristic curve) Curve (AUC) scores were over 90% with a sufficient significance interval. Also, for these tasks, cfDNA levels did not change the performance unfavourably even when the levels were below 1%. So, the method shows a good robustness against cfDNA levels as well. Finally, EPIC-seq did not show any significant changes under different pre-analytical factors, which proves that the method is robust under different circumstances that can be caused by the instruments and tools used before the analysis.