text: The environmental bacterium and opportunistic pathogen Pseudomonas aeruginosa uses quorum sensing to coordinate the formation of biofilm, swarming motility, exopolysaccharide production, virulence, and cell aggregation. These bacteria can grow within a host without harming it until they reach a threshold concentration. Then they become aggressive, developing to the point at which their numbers are sufficient to overcome the hosts immune system, and form a biofilm, leading to disease within the host as the biofilm is a protective layer encasing the bacterial population. The relative ease of growth, handling, and genetic manipulation of Pseudomonas aeruginosa has lent much research effort to the quorum sensing circuits of this relatively common bacterium. Quorum sensing in Pseudomonas aeruginosa typically encompasses two complete AHL synthase-receptor circuits, LasI-LasR and RhlI-RhlR, as well as the orphan receptor-regulator QscR, which is also activated by the LasI-generated signal. Together, the multiple AHL quorum sensing circuits of Pseudomonas aeruginosa' influence regulation of hundreds of genes.
  Another form of gene regulation that allows the bacteria to rapidly adapt to surrounding changes is through environmental signaling. Recent studies have discovered that anaerobiosis can significantly impact the major regulatory circuit of quorum sensing. This important link between quorum sensing and anaerobiosis has a significant impact on the production of virulence factors of this organism. There is hope among some humans that the therapeutic enzymatic degradation of the signaling molecules will be possible when treating illness caused by biofilms, and prevent the formation of such biofilms and possibly weaken established biofilms. Disrupting the signaling process in this way is called quorum sensing inhibition.