text: Synthetic polymers are human made through chemical reactions of monomers. Their mechanical properties are favorable in that their molecular weights can be regulated from low to high based on differing requirements. However, their lack of functional groups and structural complexity has limited their usage in organ printing. Current synthetic polymers with excellent 3D printability and in vivo tissue compatibility, include polyethylene glycol (PEG), poly(lactic-glycolic acid) (PLGA), and polyurethane (PU). PEG is a biocompatible, nonimmunogenic synthetic polyether that has tunable mechanical properties for use in 3D bioprinting. Though PEG has been utilized in various 3D printing applications, the lack of cell-adhesive domains has limited further use in organ printing. PLGA, a synthetic copolymer, is widely familiar in living creatures, such as animals, humans, plants, and microorganisms. PLGA is used in conjunction with other polymers to create different material systems, including PLGA-gelatin, PLGA-collagen, all of which enhance mechanical properties of the material, biocompatible when placed in vivo, and have tunable biodegradability. PLGA has most often been used in printed constructs for bone, liver, and other large organ regeneration efforts. Lastly, PU is unique in that it can be classified into two groups: biodegradable or non-biodegradable. It has been used in the field of bioprinting due to its excellent mechanical and bioinert properties. An application of PU would be inanimate artificial hearts; however, using existing 3D bioprinters, this polymer cannot be printed. A new elastomeric PU was created composed of PEG and polycaprolactone (PCL) monomers. This new material exhibits excellent biocompatibility, biodegradability, bioprintability, and biostability for use in complex bioartificial organ printing and manufacturing. Due to high vascular and neural network construction, this material can be applied to organ printing in a variety of complex ways, such as the brain, heart, lung, and kidney.