text: Fibrosis or scar formation is another pro-oxidant-related symptom.  E.g., interocular copper or vitreous chalicosis is associated with severe vitreous fibrosis,  as is interocular iron.  Liver cirrhosis is also a major symptom of Wilson's disease.  The  pulmonary fibrosis produced by paraquat and the antitumor agent bleomycin is also thought to be induced by the pro-oxidant properties of these agents.   It may be that oxidative stress produced by such agents mimics a normal physiological signal for fibroblast conversion to myofibroblasts.