text: The significance of peptide plane flips in the dynamics of the native state has been inferred in some proteins by comparing crystal structures of the same protein in multiple conformations.  For example, peptide flips have been described as significant in the catalytic cycle of flavodoxin and in the formation of amyloid structures, where their ability to provide a low-energy pathway between beta sheet and the so-called alpha sheet conformation is suggested to facilitate the early stages of amyloidogenesis. Peptide plane flipping may also be significant in the early stages of protein folding.