text: In biocatalysis, many reactions are sought that are absent in nature. To do this, enzymes with a small promiscuous activity towards the required reaction are identified and evolved via directed evolution or rational design.
  An example of a commonly evolved enzyme is ω-transaminase which can replace a ketone with a chiral amine and consequently libraries of different homologues are commercially available for rapid biomining (eg. Codexis).
  Another example is the possibility of using the promiscuous activities of cysteine synthase (cysM) towards nucleophiles to produce non-proteinogenic amino acids.