text: Viral RNA modifications use the same machinery as cellular RNA. This involves the use of "writer" and "reader" complexes. The writer complex contains the enzyme methyl transferase-like 3 (METTL3) and its cofactors like METTL14, WTP, KIAA1492 and RBM15/RBM15B which adds the mA modification in the nucleus.  The family of proteins known as the YTH like YTHDC1 and YTHDC2 are capable of detecting these modifications within the nucleus. In the cytoplasm, the reading duties are carried out by YTHDF1, YTHDF2, and YTHDF3.  The proteins ALKBH5 and FTO remove the mA modification, functionally serving as erasers, with the latter having a more restricted selectivity depending on the position of the modification.