text: Within the topic of gated drug delivery systems, utilizing magnetic forces generally goes hand in hand with temperature stimulus. The phenomenon of magnetic hyperthermia is when superparamagnetic nanoparticles reorient themselves after being exposed to heat generated by an alternating magnetic field (AMF). This concept has been utilized within the drug delivery field wherein gatekeepers are magnetically linked to the scaffolding and upon the application of heat, reorient and allow for the release of drug. This particular method has not been researched as heavily given the drawback that high energy is needed to produce the AMF and uncap the system. However, the Vallet-Regi lab based in Madrid, Spain decided to investigate the possibility of using magnetic gates bound to the scaffold using DNA. The lab generated oligonucleotide-modified superparamagnetic mesoporous silica nanoparticles. They capped the scaffolding using iron oxide nanoparticles that carried complementary DNA to the scaffold's oligonucleotide sequence. What the lab found was that they were able to cap their system due to the DNA coming together and creating a double strand. Upon heating the system using an AMF, the DNA bonds detached, the system became uncapped, and the drug was able to be released. Furthermore, the lab found that this linkage was reversible. As temperature was reduced, the DNA was able to re-link to its complementary half. This study was able to illustrate the possibility of having a drug delivery system that could be remotely triggered and exhibit an on-off switch.