text: Modern enantioselective synthesis typically applies a well-chosen homogeneous catalyst for key steps.  The ligands on these catalysts confer chirality.  The Josiphos family of privileged ligands provides especially high yields in enantioselective synthesis.
  In the early 1990s, Antonio Togni began studying at the Ciba (now Novartis) Central Research Laboratories previously-known ferrocenyl ligands for a Au(I)-catalyzed aldol reaction.  Tognis team began considering diphosphine ligands, and technician Josi Puleo prepared the first ligands with secondary phosphines.  The team applied Puleos products in an Ru-catalyzed enamide hydrogenation synthesis; in a dramatic success, the reaction had e.e. >99% and a turnover frequency (TOF) 0.3 s.  The same ligand proved useful in production of (S)-metolachlor, active ingredient in the most common herbicide in the United States.  Synthesis requires enantioselective hydrogenation of an imine; after introduction of the catalyst, the reaction proceeds with 100% conversion, turnover number (TON) >7mil, and turnover frequency >0.5 ms. This process is the largest-scale application of enantioselective hydrogenation, producing over 10 kilotons/year of the desired product with 79% e.e.
  Josiphos ligands also serve in non-enantioselective reactions: a Pd-catalyzed reaction of aryl chlorides and aryl vinyl tosylates with TON of 20,000 or higher, catalytic carbonylation, or Grignard and Negishi couplings A variety of Josiphos ligands are commercially available under licence from Solvias. The (R-S) and its enantiomer provide higher yields and enantioselectivities than the diastereomer (R,R).
  The ferrocene scaffold has proved to be versatile.  One structural parameter that influences reactivity is the bite angle. The P-M-P angle has an average value of 92.7°.
  The general consensus for the naming is abbreviating the individual ligand as (R)-(S)-RPF-PR'. The substituent on the Cp is written in front of the F and the R on the chiral center after the F.