text: no large clinical trials of CoQ in cancer treatment had been conducted. The US's National Cancer Institute identified issues with the few, small studies that had been carried out, stating, "the way the studies were done and the amount of information reported made it unclear if benefits were caused by the CoQ or by something else". The American Cancer Society concluded, "CoQ may reduce the effectiveness of chemo and radiation therapy, so most oncologists would recommend avoiding it during cancer treatment."