text: In metabolic control analysis, a variety of theorems have been discovered and discussed in the literature. The most well known of these are flux and concentration control coefficient summation relationships. These theorems are the result of the stoichiometric structure and mass conservation properties of biochemical networks. Equivalent theorems have not been found, for example, in electrical or economic systems.
  The summation of the flux and concentration control coefficients  were discovered independently by the Kacser/Burns group and the Heinrich/Rapoport group in the early 1970s and late 1960s.
  If we define the control coefficients using enzyme concentration, then the summation theorems are written as:
  However these theorems depend on the assumption that reaction rates are proportional to enzyme concentration. An alternative way to write the theorems is to use control coefficients that are defined with respect to the local rates which is therefore independent of how rates respond to changes in enzyme concentration:
  Although originally derived for simple linear chains of enzyme catalyzed reactions, it became apparent that the theorems applied to pathways of any structure including pathways with complex regulation involving feedback control.