text: Bennett explores which specific expression for ΔF is the most efficient, in the sense of yielding the smallest standard error for a given simulation time. He shows that the optimal choice is to take
  # , which is essentially the  Fermi–Dirac distribution (satisfying indeed the detailed balance condition).
  # . This value, of course, is not known (it is exactly what one is trying to compute), but it can be approximately chosen in a self-consistent manner. 
  Some assumptions needed for the efficiency are the following:
  # The densities of the two super states (in their common configuration space) should have a large overlap. Otherwise, a chain of super states between A and B may be needed, such that the overlap of each two consecutive super states is adequate.
  # The sample size should be large. In particular, as successive states are correlated, the simulation time should be much larger than the correlation time.
  # The cost of simulating both ensembles should be approximately equal - and then, in fact, the system is sampled roughly equally in both super states. Otherwise, the optimal expression for C is modified, and the sampling should devote equal times (rather than equal number of time steps) to the two ensembles.