text: Several processes are known to have developed for organelle biogenesis. These can range from de novo synthesis to the copying of a template organelle; the formation of an organelle from scratch and using a preexisting organelle as a template to manufacture an organelle, respectively. The distinct structures of each organelle are thought to be caused by the different mechanisms of the processes which create them and the proteins that they are made up of. Organelles may also be split between two cells during the process of cellular division (known as organelle inheritance), where the organelle of the parent cell doubles in size and then splits with each half being delivered to their respective daughter cells.
  The process of organelle biogenesis is known to be regulated by specialized transcription networks that modulate the expression of the genes that code for specific organellar proteins. In order for organelle biogenesis to be carried out properly, the specific genes coding for the organellar proteins must be transcribed properly and the translation of the resulting mRNA must be successful. In addition to this, the process requires the transfer of polypeptides to their site of function, guided by signaling peptides. If proteins are not directed to their respective sites of subcellular function, a defective organelle that fails to fulfill its tasks within the cell properly may result.
  Several metabolic diseases are known to be caused by a fault in the process of organelle biogenesis. These may include mitochondrial biogenesis defects, peroxisome biogenesis disorders, and lysosomal storage disorders.