text: Due to recent innovations to the laser spray technique, a new method of laser ablation using the spray method has surfaced. Laserspray inlet ionization (LSII) involves a matrix/analyte sample at atmospheric pressure being ablated, and the ionization process will take place in an ion transfer capillary tube located in the mass spectrometer inlet.  The LSII method is also known as laserspray ionization vacuum (LSIV).