text: The ideal statin should have the following properties:
  *High affinity for the enzyme active site
  *Marked selectivity of uptake into hepatic cells compared with non-hepatic cells
  *Low systemic availability of active inhibitory equivalents
  *Relatively prolonged duration of effect.
  One of the main design objectives of statin design is the selective inhibition of HMGR in the liver, as cholesterol synthesis in non-hepatic cells is needed for normal cell function and inhibition in non-hepatic cells could possibly be harmful.