text: VMAT1 is found in both large dense-core vesicles (LDCVs) as well as in small synaptic vesicles (SSVs). This was discovered via studying rat adrenal medulla cells (PC12 cells).  LDCVs are 70-200 nm in size and exist throughout the neuron (soma, dendrites, etc.).  SSVs are much smaller (usually about 40 nm) and typically exist as clusters in the presynaptic cleft.