text: Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H/K ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease.
  PPIs also can bind to other types of proton pumps such as  those that occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance.