text: At least seven orally active TRPV1 antagonist substances have progressed into clinical development and several more are in preclinical development. The ligand GRC-6211, by Eli Lilly and Company-Glenmark is the most advanced and is currently in phase IIb clinical trials. GlaxoSmithKline, Merck-Neurogen, Amgen, and AstraZeneca are all developing TRPV1 antagonist and all are developing substances that have completed phase I trials successfully.