text: Under steady-state conditions, the catalyst and substrate undergo reversible association followed by a relatively rapid consumption of the catalyst–substrate complex (by both forward reactions to product and reverse reactions to unbound catalyst.) The steady-state approximation holds that the concentration of the catalyst-substrate complex is not changing over time; the total concentration of this complex remains low as it is whisked away almost immediately after formation. A steady-state rate law contains all of the rate constants and species required to go from starting material to product, while the denominator consists of a sum of terms describing the relative rates of the forward and reverse reactions consuming the steady-state intermediate. For the simplest case where one substrate goes to one product through a single intermediate:
  In a slightly more complex situation where two substrates bind in sequence followed by product release:
  Increasingly complex systems can be described simply with the algorithm described in this reference.
  In the case of the steady-state conditions described above, the catalyst resting state is the unbound form (because the substrate-bound intermediate is, by definition, only present at a minimal concentration.)