text: Jorgensens research interests are broad and include the calculation of free energy of reactions using quantum mechanics, molecular mechanics, and Metropolis Monte Carlo methods, with application to the calculation of protein-ligand binding affinities, which have pharmaceutical applications. Most generally, the research goals include the development of theoretical and computational methods in an attempt to gain a deeper understanding of the structure and reactivity for organic and biomolecular systems. Another relevant research topic of his is in the development of improved NNRTIs, which are used for the treatment of HIV.