text: The inositol-phospholipid signaling pathway is responsible for the generation of IP3 through the cleavage of Phosphatidylinositol 4,5-bisphosphate (PIP2) found in the lipid bi-layer of the plasma membrane by phospholipase C in response to either receptor tyrosine kinase or Gq alpha subunit-G protein-coupled receptor signaling. Soluble inositol trisphosphate (IP3) is able to rapidly diffuse into the cytosol and bind to the inositol trisphosphate receptor (InsP3Rs) calcium channels located in the endoplasmic reticulum. This releases calcium into the cytosol, serving as a rapid and potent signal for various cellular processes.
  Further reading: Function of calcium in humans