text: Whether or not a given individuals brain can deal effectively with stress, and thus their susceptibility to depression, depends on the β-catenin in each persons brain, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published November 12, 2014, in the journal Nature. Higher β-catenin signaling increases behavioral flexibility, whereas defective β-catenin signaling leads to depression and reduced stress management.