text: Developmental processes provide an example of how changes in synexpression control networks could significantly affect an organism's capacity to evolve and adapt effectively.  In animals, it is often beneficial for appendages to co-evolve, and it has been observed that fore-and hind-limbs share expression of Hox genes early in metazoan development. Thus, changes in the regulatory patterns of these genes would affect the development of both the fore- and hind-limbs, facilitating co-evolution.