text: Transcription factor TFA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA.  TFA is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II.  Other GTFs include TFD, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TFB, TFE, TFF, and TFH.  Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.