text: Mechanistically, eukaryotic translation termination matches its prokaryotic counterpart. In this case, termination of the polypeptide chain is achieved through the hydrolytic action of a heterodimer consisting of release factors, eRF1 and eRF3. Translation termination is said to be leaky in some cases as noncoding-tRNAs may compete with release factors to bind stop codons. This is possible due to the matching of 2 out 3 bases within the stop codon by tRNAs that may occasionally outcompete release factor base pairing.  An example of regulation at the level of termination is functional translational readthrough of the lactate dehydrogenase gene LDHB. This readthrough provides a peroxisomal targeting signal that localizes the distinct LDHBx to the peroxisome.