text: c-Src is a gene that codes for proto-oncogene tyrosine-protein kinase Src, a protein important for normal mitotic cycling. It is phosphorylated and dephosphorylated to turn signaling on and off. Proto-oncogene tyrosine-protein kinase Src must be localized to the plasma membrane in order to phosphorylate other downstream targets; myristoylation is responsible for this membrane targeting event. Increased myristoylation of c-Src can lead to enhanced cell proliferation and be responsible for transforming normal cells into cancer cells. Activation of c-Src can lead to the so-called "hallmarks of cancer", among them upregulation of angiogenesis, proliferation, and invasion.