text: Transforming growth factor beta-1-induced transcript 1 plays a role in a number of cell functions. Originally, TGFB1I1 was isolated as a senescence-inducing gene from mouse osteoblastic cells through treatment with transforming growth factor beta-1 and hydrogen peroxide. During this, TGFB1I1 was also being independently discovered by numerous other groups and was characterized as a focal adhesion protein, an androgen and glucocorticoid receptor co-activator, a negative regulator of muscle differentiation, and major player in the recovery of arterial media.