text: While Picard is right in principle that misuse of antibiotics promotes resistance, this is not the key problem in the case of tuberculosis. TB bacteria are special little critters, and there is little overlap between the drugs used against them and those used against other bacterial pathogens; therefore, misuse of the latter class has little effect on TB. 
  
  A key problem with TB is drug cost. As stated in the article, you use a combination of 3 or 4 effective drugs. The key reason is to prevent emergence of resistance under treatment: bugs are much less likely to acquire resistance to multiple drugs all at once than to a single one. 
  
  Now, if you are poor and nobody pays for your treatment, and you are prescribed 4 expensive drugs, what are you going to do? Right, you only buy the cheapest 1 or 2. Your bugs become resistant, and you infect other people. That partial resistance now serves as a jumping board for the bug to become resistant to the other drugs in the combination as well.