Nephrogenic systemic fibrosis can begin days to months, and even years, after exposure to an older gadolinium-based contrast agent (group 1). Some signs and symptoms of nephrogenic systemic fibrosis may include:  Swelling and tightening of the skin Reddened or darkened patches on the skin Thickening and hardening of the skin, typically on the arms and legs and sometimes on the body, but almost never on the face or head Skin that may feel "woody" and develop an orange-peel appearance Burning, itching or severe sharp pains in areas of involvement Skin thickening that inhibits movement, resulting in loss of joint flexibility Rarely, blisters or ulcers  In some people, involvement of muscles and body organs may cause:  Muscle weakness Limitation of joint motion caused by muscle tightening (contractures) in arms, hands, legs and feet Bone pain, particularly in the hip bones or ribs Reduced internal organ function, including heart, lung, diaphragm, gastrointestinal tract or liver Yellow plaques on the white surface (sclera) of the eyes  The condition is generally long term (chronic), but some people may improve. In a few people, it can cause severe disability, even death.
nephrogenic systemic fibrosis can begin days months  years  exposure older gadolinium-based contrast agent (group 1)  signs symptoms nephrogenic systemic fibrosis may include:  swelling tightening skin reddened darkened patches skin thickening hardening skin  typically arms legs body  face head skin may feel "woody" develop orange-peel appearance burning  itching severe sharp pains areas involvement skin thickening inhibits movement  resulting loss joint flexibility rarely  blisters ulcers  people  involvement muscles body organs may cause:  muscle weakness limitation joint motion caused muscle tightening (contractures) arms  hands  legs feet bone pain  hip bones ribs reduced internal organ function  including heart  lung  diaphragm  gastrointestinal tract liver yellow plaques white surface (sclera) eyes  condition generally long term (chronic)  people may improve  people  can cause severe disability  death
nephrogenic systemic fibrosis