Pancreatic neuroendocrine tumors sometimes don't cause symptoms. When they do, signs and symptoms can include:  Stomach ulcers Heartburn Diabetes Weakness Fatigue Muscle cramps Indigestion Diarrhea Weight loss Skin rash Constipation Pain in your abdomen or back Yellowing of your skin or eyes Low blood sugar  Causes It's not clear what causes most pancreatic neuroendocrine tumors. Pancreatic neuroendocrine tumors occur when hormone-producing cells in the pancreas (islet cells) develop changes (mutations) in their DNA — the material that provides instructions for every chemical process in your body. DNA mutations cause changes in these instructions. One result is that cells may begin to grow out of control and eventually form a tumor — a mass of cancerous cells. Sometimes the cancer cells break away and spread to other organs, such as the liver. Some inherited syndromes increase the risk of this type of cancer, including:  Multiple endocrine neoplasia, type 1 (MEN 1) syndrome Von Hippel-Lindau disease Von Recklinghausen's disease (neurofibromatosis 1) Tuberous sclerosis  Risk factors Factors that are associated with an increased risk of pancreatic neuroendocrine tumors include:  Being male. Men are much more likely than women to develop these tumors. A family history of pancreatic neuroendocrine tumors. If a family member was diagnosed with pancreatic neuroendocrine tumor, your risk is increased. You may have multiple endocrine neoplasia, type 1 (MEN 1) syndrome, which increases the risk of this type of tumor.                   By Mayo Clinic Staff By Mayo Clinic Staff  Pancreatic neuroendocrine tumors care at Mayo Clinic 
pancreatic neuroendocrine tumors don't cause symptoms  do  signs symptoms can include:  stomach ulcers heartburn diabetes weakness fatigue muscle cramps indigestion diarrhea weight loss skin rash constipation pain abdomen back yellowing skin eyes low blood sugar  causes it's clear causes pancreatic neuroendocrine tumors  pancreatic neuroendocrine tumors occur hormone-producing cells pancreas (islet cells) develop changes (mutations) dna — material instructions chemical process body  dna mutations cause changes instructions  result cells may begin grow control eventually form tumor — mass cancerous cells  cancer cells break away spread organs  liver  inherited syndromes increase risk type cancer  including:  multiple endocrine neoplasia  type 1 (men 1) syndrome von hippel-lindau disease von recklinghausen's disease (neurofibromatosis 1) tuberous sclerosis  risk factors factors associated increased risk pancreatic neuroendocrine tumors include:  being male  men likely women develop tumors  family history pancreatic neuroendocrine tumors  family member diagnosed pancreatic neuroendocrine tumor  risk increased  may multiple endocrine neoplasia  type 1 (men 1) syndrome  increases risk type tumor                    mayo clinic staff mayo clinic staff  pancreatic neuroendocrine tumors care mayo clinic 
pancreatic neuroendocrine tumors