In Crohn's disease, any part of your small or large intestine can be involved. It may involve multiple segments, or it may be continuous. In some people, the disease is only in the colon, which is part of the large intestine. Signs and symptoms of Crohn's disease can range from mild to severe. They usually develop gradually, but sometimes will come on suddenly, without warning. You may also have periods of time when you have no signs or symptoms (remission). When the disease is active, symptoms typically include:  Diarrhea Fever Fatigue Abdominal pain and cramping Blood in your stool Mouth sores Reduced appetite and weight loss Pain or drainage near or around the anus due to inflammation from a tunnel into the skin (fistula)  Other signs and symptoms People with severe Crohn's disease may also experience symptoms outside of the intestinal tract, including:  Inflammation of skin, eyes and joints Inflammation of the liver or bile ducts Kidney stones Iron deficiency (anemia) Delayed growth or sexual development, in children 
crohn's disease  part small large intestine can involved  may involve multiple segments  may continuous  people  disease only colon  part large intestine  signs symptoms crohn's disease can range mild severe  develop gradually  will come suddenly  warning  may periods time signs symptoms (remission)  disease active  symptoms typically include:  diarrhea fever fatigue abdominal pain cramping blood stool mouth sores reduced appetite weight loss pain drainage near anus due inflammation tunnel skin (fistula)  signs symptoms people severe crohn's disease may experience symptoms intestinal tract  including:  inflammation skin  eyes joints inflammation liver bile ducts kidney stones iron deficiency (anemia) delayed growth sexual development  children 
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