Symptoms usually come and go, and may include:  Skin lesions. Most people with cryoglobulinemia develop purplish skin lesions on their legs. In some people, leg ulcers also occur. Joint pain. Symptoms resembling rheumatoid arthritis are common in cryoglobulinemia. Peripheral neuropathy. Cryoglobulinemia can damage the nerves at the tips of your fingers and toes, causing numbness and other problems.  Causes Cryoglobulinemia has been associated with:  Infections. Hepatitis C is the most common infection associated with cryoglobulinemia. Others include hepatitis B, HIV, Epstein-Barr, toxoplasmosis and malaria. Certain cancers. Some cancers of the blood, such as multiple myeloma, Waldenstrom macroglobulinemia and chronic lymphocytic leukemia, can sometimes cause cryoglobulinemia. Autoimmune disorders. Disease such as lupus, rheumatoid arthritis and Sjogren's syndrome increase the risk of developing cryoglobulinemia.  Risk factors Risk factors of cryoglobulinemia may include:  Your sex. Cryoglobulinemia occurs more frequently in women than in men. Age. Symptoms of cryoglobulinemia usually begin in middle age. Other diseases. Cryoglobulinemia is associated with diseases such as hepatitis C, HIV, multiple myeloma, Waldenstrom macroglobulinemia, lupus and Sjogren's syndrome.                   By Mayo Clinic Staff By Mayo Clinic Staff  Cryoglobulinemia care at Mayo Clinic 
symptoms come go  may include:  skin lesions  people cryoglobulinemia develop purplish skin lesions legs  people  leg ulcers occur  joint pain  symptoms resembling rheumatoid arthritis common cryoglobulinemia  peripheral neuropathy  cryoglobulinemia can damage nerves tips fingers toes  causing numbness problems   causes cryoglobulinemia associated with:  infections  hepatitis common infection associated cryoglobulinemia  include hepatitis b  hiv  epstein-barr  toxoplasmosis malaria  cancers  cancers blood  multiple myeloma  waldenstrom macroglobulinemia chronic lymphocytic leukemia  can cause cryoglobulinemia  autoimmune disorders  disease lupus  rheumatoid arthritis sjogren's syndrome increase risk developing cryoglobulinemia   risk factors risk factors cryoglobulinemia may include:  sex  cryoglobulinemia occurs frequently women men  age  symptoms cryoglobulinemia begin middle age  diseases  cryoglobulinemia associated diseases hepatitis c  hiv  multiple myeloma  waldenstrom macroglobulinemia  lupus sjogren's syndrome                    mayo clinic staff mayo clinic staff  cryoglobulinemia care mayo clinic 
cryoglobulinemia