Signs and symptoms of primary lateral sclerosis usually take years to progress and generally begin in the legs. Rarely, PLS begins in your tongue or hands and then progresses down your spinal cord to your legs. However, the disease has highly variable effects from person to person. Signs and symptoms may include: PLS  Stiffness, weakness and muscle spasms (spasticity) in your legs, rarely starting in one leg, and eventually progressing to your arms, hands, tongue and jaw Slowed movement Tripping, clumsiness and difficulty with balance Hand clumsiness Hoarseness, as well as slowed, slurred speech and drooling Difficulties with chewing and swallowing Sometimes, frequent, rapid and intense shifts in emotions (mood lability) Rarely, breathing problems and bladder problems late in the disease 
signs symptoms primary lateral sclerosis take years progress generally begin legs  rarely  pls begins tongue hands progresses down spinal cord legs  however  disease highly variable effects person person  signs symptoms may include: pls  stiffness  weakness muscle spasms (spasticity) legs  rarely starting leg  eventually progressing arms  hands  tongue jaw slowed movement tripping  clumsiness difficulty balance hand clumsiness hoarseness  well slowed  slurred speech drooling difficulties chewing swallowing sometimes  frequent  rapid intense shifts emotions (mood lability) rarely  breathing problems bladder problems late disease 
primary lateral sclerosis