Signs and symptoms of systemic mastocytosis depend on the part of the body affected by excessive mast cells. Too many mast cells can build up in the skin, liver, spleen, bone marrow or intestines. Less commonly, other organs such as the brain, heart or lungs also may be affected. Signs and symptoms of systemic mastocytosis may include:  Flushing, itching or hives Abdominal pain, diarrhea, nausea or vomiting Anemia or bleeding disorders Bone and muscle pain Enlarged liver, spleen or lymph nodes Depression, mood changes or problems concentrating  The mast cells are triggered to produce substances that cause inflammation and symptoms. People have different triggers, but the most common ones include:  Alcohol Skin irritation Spicy foods Exercise Insect stings Certain medications  When to see a doctor When to see a doctor  Talk to your doctor if you have problems with flushing or hives, or if you have concerns about the signs or symptoms listed above. Causes Most cases of systemic mastocytosis are caused by a random change (mutation) in the KIT gene. Typically this flaw in the KIT gene is not inherited. Too many mast cells are produced and build up in tissues and body organs, releasing substances such as histamine, leukotrienes and cytokines that cause inflammation and symptoms. Complications Complications of systemic mastocytosis can include:  Anaphylactic reaction. This severe allergic reaction includes signs and symptoms such as rapid heartbeat, fainting, loss of consciousness and shock. If you have a severe allergic reaction, you may need an injection of epinephrine. Blood disorders. These can include anemia and poor blood clotting. Peptic ulcer disease. Chronic stomach irritation can lead to ulcers and bleeding in your digestive tract. Reduced bone density. Because systemic mastocytosis can affect your bones and bone marrow, you may be at risk of bone problems, such as osteoporosis. Organ failure. A buildup of mast cells in body organs can cause inflammation and damage to the organ.                   By Mayo Clinic Staff By Mayo Clinic Staff  Systemic mastocytosis care at Mayo Clinic 
signs symptoms systemic mastocytosis depend part body affected excessive mast cells  mast cells can build skin  liver  spleen  bone marrow intestines  commonly  organs brain  heart lungs may affected  signs symptoms systemic mastocytosis may include:  flushing  itching hives abdominal pain  diarrhea  nausea vomiting anemia bleeding disorders bone muscle pain enlarged liver  spleen lymph nodes depression  mood changes problems concentrating  mast cells triggered produce substances cause inflammation symptoms  people triggers  common ones include:  alcohol skin irritation spicy foods exercise insect stings medications  see doctor see doctor  talk doctor problems flushing hives  concerns signs symptoms listed above  causes cases systemic mastocytosis caused random change (mutation) kit gene  typically flaw kit gene inherited  mast cells produced build tissues body organs  releasing substances histamine  leukotrienes cytokines cause inflammation symptoms  complications complications systemic mastocytosis can include:  anaphylactic reaction  severe allergic reaction includes signs symptoms rapid heartbeat  fainting  loss consciousness shock  severe allergic reaction  may need injection epinephrine  blood disorders  can include anemia poor blood clotting  peptic ulcer disease  chronic stomach irritation can lead ulcers bleeding digestive tract  reduced bone density  systemic mastocytosis can affect bones bone marrow  may risk bone problems  osteoporosis  organ failure  buildup mast cells body organs can cause inflammation damage organ                    mayo clinic staff mayo clinic staff  systemic mastocytosis care mayo clinic 
systemic mastocytosis