More than half the people with primary biliary cholangitis do not have any noticeable symptoms when diagnosed. The disease may be diagnosed when blood tests are done for other reasons, such as routine testing. Symptoms eventually develop over the next 5 to 20 years. Those who do have symptoms at diagnosis typically have poorer outcomes. Common early symptoms include:  Fatigue Itchy skin  Later signs and symptoms may include:  Dry eyes and mouth Pain in the upper right abdomen Swelling of the spleen (splenomegaly) Bone, muscle or joint (musculoskeletal) pain Swollen feet and ankles (edema) Buildup of fluid in the abdomen due to liver failure (ascites) Fatty deposits (xanthomas) on the skin around the eyes, eyelids or in the creases of the palms, soles, elbows or knees Yellowing of the skin and eyes (jaundice) Darkening of the skin that's not related to sun exposure (hyperpigmentation) Weak and brittle bones (osteoporosis), which can lead to fractures High cholesterol Diarrhea, which may include greasy stools (steatorrhea) Underactive thyroid (hypothyroidism) Weight loss 
half people primary biliary cholangitis noticeable symptoms diagnosed  disease may diagnosed blood tests reasons  routine testing  symptoms eventually develop next 5 20 years  who symptoms diagnosis typically poorer outcomes  common early symptoms include:  fatigue itchy skin  later signs symptoms may include:  dry eyes mouth pain upper right abdomen swelling spleen (splenomegaly) bone  muscle joint (musculoskeletal) pain swollen feet ankles (edema) buildup fluid abdomen due liver failure (ascites) fatty deposits (xanthomas) skin eyes  eyelids creases palms  soles  elbows knees yellowing skin eyes (jaundice) darkening skin that's sun exposure (hyperpigmentation) weak brittle bones (osteoporosis)  can lead fractures high cholesterol diarrhea  may include greasy stools (steatorrhea) underactive thyroid (hypothyroidism) weight loss 
primary biliary cholangitis