Signs and symptoms of ALS vary greatly from person to person, depending on which neurons are affected. It generally begins with muscle weakness that spreads and gets worse over time. Signs and symptoms might include: ALS  Difficulty walking or doing normal daily activities Tripping and falling Weakness in your legs, feet or ankles Hand weakness or clumsiness Slurred speech or trouble swallowing Muscle cramps and twitching in your arms, shoulders and tongue Inappropriate crying, laughing or yawning Cognitive and behavioral changes  ALS often starts in the hands, feet or limbs, and then spreads to other parts of your body. As the disease advances and nerve cells are destroyed, your muscles get weaker. This eventually affects chewing, swallowing, speaking and breathing. ALS There's generally no pain in the early stages of ALS, and pain is uncommon in the later stages. ALS doesn't usually affect your bladder control or your senses.
signs symptoms als vary greatly person person  depending neurons affected  generally begins muscle weakness spreads worse time  signs symptoms include: als  difficulty walking normal daily activities tripping falling weakness legs  feet ankles hand weakness clumsiness slurred speech trouble swallowing muscle cramps twitching arms  shoulders tongue inappropriate crying  laughing yawning cognitive behavioral changes  als starts hands  feet limbs  spreads parts body  disease advances nerve cells destroyed  muscles weaker  eventually affects chewing  swallowing  speaking breathing  als there's generally pain early stages als  pain uncommon later stages  als doesn't affect bladder control senses
amyotrophic lateral sclerosis