Signs and symptoms of multiple myeloma can vary and, early in the disease, there may be none. When signs and symptoms do occur, they can include:  Bone pain, especially in your spine or chest Nausea Constipation Loss of appetite Mental fogginess or confusion Fatigue Frequent infections Weight loss Weakness or numbness in your legs Excessive thirst 
signs symptoms multiple myeloma can vary and  early disease  may none  signs symptoms occur  can include:  bone pain  especially spine chest nausea constipation loss appetite mental fogginess confusion fatigue frequent infections weight loss weakness numbness legs excessive thirst 
multiple myeloma