Early indications of mixed connective tissue disease can include:  General feeling of being unwell. This can include increased fatigue and a mild fever. Cold and numb fingers or toes (Raynaud's phenomenon). In response to cold or stress, your fingers or toes might turn white and then purplish blue. After warming, the fingers or toes turn red. Swollen fingers or hands. Some people have swelling of the fingers. Muscle and joint pain. Joints can become inflamed, swollen and deformed, similar to what occurs with rheumatoid arthritis. Rash. Red or reddish brown patches can appear over the knuckles. 
early indications mixed connective tissue disease can include:  general feeling being unwell  can include increased fatigue mild fever  cold numb fingers toes (raynaud's phenomenon)  response cold stress  fingers toes turn white purplish blue  warming  fingers toes turn red  swollen fingers hands  people swelling fingers  muscle joint pain  joints can inflamed  swollen deformed  similar occurs rheumatoid arthritis  rash  red reddish brown patches can knuckles
mixed connective tissue disease