Primary sclerosing cholangitis is often diagnosed before symptoms appear when a routine blood test or an X-ray taken for an unrelated condition shows liver abnormalities. Early signs and symptoms often include:  Fatigue Itching Yellow eyes and skin (jaundice) Abdominal pain  Many people diagnosed with primary sclerosing cholangitis before they have symptoms continue to feel generally well for several years. But there's no reliable way to predict how quickly or slowly the disease will progress for any individual. Signs and symptoms that may appear as the disease progresses include:  Fever Chills Night sweats Enlarged liver Enlarged spleen Weight loss 
primary sclerosing cholangitis diagnosed symptoms routine blood test x-ray taken unrelated condition shows liver abnormalities  early signs symptoms include:  fatigue itching yellow eyes skin (jaundice) abdominal pain  people diagnosed primary sclerosing cholangitis symptoms continue feel generally well years  there's reliable way predict quickly slowly disease will progress individual  signs symptoms may disease progresses include:  fever chills night sweats enlarged liver enlarged spleen weight loss 
primary sclerosing cholangitis