One of the most common signs of primary immunodeficiency is having infections that are more frequent, longer lasting or harder to treat than are the infections of someone with a typical immune system. You may also get infections that a person with a healthy immune system likely wouldn't get (opportunistic infections). Signs and symptoms differ depending on the type of primary immunodeficiency disorder, and they vary from person to person. Signs and symptoms of primary immunodeficiency can include:  Frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections Inflammation and infection of internal organs Blood disorders, such as low platelet count or anemia Digestive problems, such as cramping, loss of appetite, nausea and diarrhea Delayed growth and development Autoimmune disorders, such as lupus, rheumatoid arthritis or type 1 diabetes 
common signs primary immunodeficiency infections frequent  longer lasting harder treat infections typical immune system  may infections person healthy immune system likely wouldn't (opportunistic infections)  signs symptoms differ depending type primary immunodeficiency disorder  vary person person  signs symptoms primary immunodeficiency can include:  frequent recurrent pneumonia  bronchitis  sinus infections  ear infections  meningitis skin infections inflammation infection internal organs blood disorders  low platelet count anemia digestive problems  cramping  loss appetite  nausea diarrhea delayed growth development autoimmune disorders  lupus  rheumatoid arthritis type 1 diabetes 
primary immunodeficiency