Neurodegenerative Disease, Neuroscience, Translational Research, Neurobiology, Pathology.
induces TDP-43 pathology, which spreads over time. Ageing and cellular stress — conditions known to affect homeostasis — may lead to the accumulation of cellular TDP-43. Such cellular accumulation may act as ‘seeds’ leading to the growth and spread of TDP-43 in the brain, with certain neuronal