Alzheimers, Alzheimers Disease, Tauopathies, Disease, Health.
to create knock-in mice, animals bred with an inserted mutated gene in their DNA that prevented the polyglutamylation of the tubulin-α subunit (C-terminal) end (Figure 2, right). Next, they bred tauopathy-model mice with a defective human tau gene inserted in their DNA. This resulted in ‘mutant’