Neurodegenerative Disease, Neuroscience, Translational Research, Neurobiology, Pathology.
α-Syn, LBs also contain other proteins and cellular materials. These insoluble clumps are a key feature of PD and other neurodegenerative diseases. In laboratory conditions, the small building blocks (monomers) of α-Syn aggregate to form amyloid fibrils known as pre-formed fibrils (PFFs). These