Molecular Biology, Oncology, Research, Cell Signalling, Medical.
(1). The signalling pathway begins with the binding of VEGF Receptors (VEGFR) to the VEGF cytokine to form a homodimer, a process known as Dimerization (2). The binding of a VEGF molecule to two VEGFR molecules induces the transphosphorylation of the intracellular domains of the receptors, leading