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Nano Research 
July 2017, Volume 10, Issue 7, pp 2234–2243 | Cite as

“Takeaway” drug delivery: A new nanomedical paradigm



An alternative model to the well-established paradigm of the externally switchable drug delivery systems is herein proposed. In contrast to the on–off archetype, here the amount of released drug is pre-set by the application of an external stimulus, and is gradually released after the withdrawal of the exogenous signal. These attributes are achieved through an innovative approach featuring the integration of plasmonic nanovehicles in a polymer-based film. Such a platform is provided with optically responsive capabilities together with multiple diffusional barriers, allowing for an “on-demand” time-limited release where light acts as a therapeutic “starting shot”. These nanoarchitectured depots have great potential as implantable drug delivery systems in clinical scenarios where a recurrent, sustained, and yet, on–off administration of medication is required. The application of these hybrid materials may extend the implementation of nanomedicine strategies beyond the point-of-care setting.


release plasmonic nanocapsule hydrogel NIR





This work was funded by Xunta de Galicia (No. EM2014/035), MINECO-Spain (No. CTM2014-58481-R), and Fundación Tatiana Pérez de Guzmán el Bueno.



© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016




González-Domínguez, E., Rodríguez-González, B., Pérez-Lorenzo, M. et al. Nano Res. (2017) 10: 2234. https://doi.org/10.1007/s12274-016-1412-3



