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September 2018, Volume 13, Issue 6, pp 977–978 | Cite as

Noninvasive auto-titrating ventilation (AVAPS-AE) versus average volume-assured pressure support (AVAPS) ventilation in hypercapnic respiratory failure patients: reply



We would like to thank Dr. Briones Claudett KH and Dr. Grunauer M for their interest in our study and encouraging discussion of the use of this relatively new noninvasive auto-titrating ventilation (AVAPS-AE) mode, in critically ill hypercapnic patients [1].

In their letter, they state that the heterogeneity of our selected group of hypercapnic patients leads to difficult interpretation of the results, since the prognostication differs with entities. We also accept this point, and refer to our limitations [2]. This is a preliminary study and before performing our future prospective study that will evaluate the AVAPS-AE efficiency in patients with obesity hypoventilation (OHS) and obstructive sleep apnea syndrome (OSAS) with the support of polysomnography (PSG), we just wanted to examine the effect of this new mode in all the hypercapnic patient-cohort of our intensive care unit (ICU) [2].

The authors mention that studies suggesting auto-titrating noninvasive ventilation...




The authors declare that they have no conflict of interest. All authors disclose any financial support or relationships that may pose conflict of interest. This includes any financial arrangements authors have with a company whose product figures prominently in the submitted manuscript or with a company making a competing product. All authors state explicitly that they have no any potential conflicts.


Human rights are followed in this study.


The Local Ethics Committee approved this study (No: 894-2015) and exempted it from the informed consent requirement because researchers accessed an anonymized database retrospectively for this analysis.



© SIMI 2018




Zerman, A., Aydogdu, M. & Gursel, G. Intern Emerg Med (2018) 13: 977. https://doi.org/10.1007/s11739-018-1862-6



