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MAURIZI Lionel (English version)


Researchgate profile

With a chemical engineering background I started in 2010 a PhD in physical-chemistry on the syntheses and characterizations of nanoparticles for biomedical applications. While going deeper into my nanoparticles skills I learned new knowledge on toxicities and biological behaviors of nanohybrids made for medical purposes.

During my postdoctoral experiences from 2011 to 2016, in particular at EPFL, I continued working on synthesis and characterizations methods "GMP-like" for nanomaterials in order to answer pharmaceutical and medical requirements. I also focused my research on the study and the understanding of the role of nanoobjects physico-chemistry on the living world especially their interactions with protein from biological media: the "Protein Corona"

This thematic is driving my actual research at ICB Laboratory.

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2007-2010: After a chemical engineering diploma from the University of Technology of Compiegne (UTC), I started a PhD in physical chemistry at the ICB Laboratory on the Elaboration of functionalized nanoparticles: applications as MRI contrast agent. My research was focused on the syntheses of magnetic nanparticles via soft chemistry or hydrothermal and continuous methods with an accurate control of the physicochemical properties and in depth characterizations. Nanoparticles' surfaces were also modified and functionalized for a better biocompatibility, less toxicity and targeting behviors in order to be used as a Magnetic Resonance Imaging (MRI) contrast agent.

2011-2015: I worked for 4 years in Pr. H. Hofmann's team at the Ecole Polytechnique Fédérale de Lausanne (EPFL) on a FP7 European project (Nanodiara) on the development of novel nanotechnology based diagnostic and therapeutic systems for arthritic diseases. My research was centered on one part on the reproducibility and scale-up of the syntheses and methods to face biomedical challenges. On another part, I studied the interactions between nanoparticles and proteins in order to better understand their biological behaviors. This scientific area is commonly called: the "Protein Corona".

2015-2016: After these projects, I continued my research at Dublin City University (Pr. Dermot Brougham) on a FP7 European project (UNION). Then at Basel University (Pr. Cornelia Palivan) I worked on a Swiss project NCCR (National Centres of Competence in Research). These two projects were focused on the development of physicochemical solutions for biomedical applications such as  "nano-flowers" or "nano-vesicles".

Since the end of 2016: I got a CNRS Researcher (CR) permanent position at Pr. Nadine Millot's team from the nanosciences department of the ICB laboratory to continue working on my thematic focused on  the development of nanomedical solutions and on the understanding of their biological behaviors.

Main fields of expertise

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2017-2018:BQR Project (Bonus on Quality and Research): In vivo interactions of biocompatible nanoparticles with biological proteins: influence on biodistribution

Main projects completed

From 2011 to 2014 at EPFL: FP7 European project (Nanodiara) on the development of nanotechnological tools for the detection and the therapy of arthrtic diseases.
 
Although treatment of rheumatoid arthritis (RA) has improved in the last years, there is still no disease modifying treatment for osteoarthritis (OA). For treatments to be effective it is considered extremely important to detect and treat these diseases early and then be able to monitor treatment efficacy early on (within weeks or months) after its initiation rather than waiting up to a year for RA and 18 months for OA. RA is a chronic inflammatory joint disease that involves acute and chronic synovial (joint lining) inflammation causing the erosive destruction of articular cartilages, ligaments and subchondral bone. It develops in about 1% of the population. OA, currently the main cause of disability among the middle age and elderly populations, is a degenerative arthritis involving much less synovial inflammation in most patients, with a prevalence of about 12% of the population.
The main objective of the NanoDiaRA project is the development of nanotechnology-based diagnostic tools for easy and early detection of disease onset, progression and responses to therapy RA and OA via specific targeting of inflamatory areas and imaging with Magnetic Resonance Imaging (MRI).  New blood and urine nanotechnology-based diagnostic biomarker assayswas also develpped to be a very sensitive, easy to use and affordable immunoassay benchtop analytical systems for widespread clinical use. In view of the development of this targeted nanoparticle-based technology there are also opportunities to use this tissue-targeted approach for locally controlled drug release (e.g. in joints alone/intra-articular). This way of improving drug delivery to minimize possible side effects is a long term future approach which will be examined for its feasibility during the term of the project. The overall project follows a personalized medicine approach and is driven by the prominent unmet clinical needs outlined above.
The NanoDiaRA project is divided into five research work packages and four supporting work packages. While the research packages deal with fundamental research, the latter are particularly addressing dissemination, publication and valorization of the research outcome, investigation of the ethical issues, training of young investigators and the administration of the project.

Research Work Packages:

Work packages de support:

It pooled 15 European partners européens from academic and industrail fields:

Role during the project:

As a scientist and WP leader at EPFL, my role was pivotal and consisted in bringing nanotechnological solutions to our biological, industrial and medical partners. As main responsibles of the WP 1, we worked in close collaborations with all the scientific WP to develop specific nanoparticles for arthritic pathologies with industrial requirements such as biocompatibility and upscalable methods to have enough quantity of materials for pharmacokinetic studies. We also studied in depth the biological behaviors of our nanohybrids (toxicity, internalization, biodistribution or Protein Corona).

In 2016 at Basel University: Swiss project NCCR (National Centres of Competence in Research) Molecular Systems Engineering on the development of innovative molecular systems approaching the complexity of a cell.
 
This NCCR project was pooling multidisciplinary areas from the physics and chemistry to the biology, the biostatistics and the computer sciences.

The main objctive of the "Molecular Systems Engineering" project was to create complex molecular layouts to mimic cellular reactions. Such systems can be use as organic molecules (enzymes for example) industrial productions or to control cellular systemps for applications in health.

The Molecular Systems Egineering project was divided into 4 Work Packages (more details).

It pooled 9 Swiss partners from academic and industrail fields:


As a scientist in the WP 2 of University of Basel, my role was to develop stimulo-sensitive membranes made from the assembly of polymeric vesicles (polymersomes) and inorganic nanoparticles functionalized with DNA. These membranes shoul induce cascade reactions between the vesicles and catalyzed by the chosen nanoparticles (more details).


29 articles in peer-reviewed journals

3 international conferences proceedings

2 Book chapters

List of publications from Web of Science

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Conference proceedings

ORCID number: 0000-0002-6346-7623

Google scholar ; ResearcherID: E-3606-2016 and Scopus: 40262179400 accounts

Most significant publications




44 international and national conferences including:

5 invited talks with international collaborators

Recent selection:



36 hours per year on supervised project: Fifth year of engineering school: ESIREM (École supérieure d'ingénieurs de recherche en matériaux et en infotronique)


The supervision's proportions are given in brackets.

International collaborations


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