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Mapping Protein–Protein Interactions of the Resistance-Related Bacterial Zeta Toxin–Epsilon Antitoxin Complex (ε2ζ2) with High Affinity Peptide Ligands Using Fluorescence Polarization

Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication

Dynamic Duo—The Salmonella Cytolethal Distending Toxin Combines ADP-Ribosyltransferase and Nuclease Activities in a Novel Form of the Cytolethal Distending Toxin
 Volume 8, Issue 7
 







Toxins 2016, 8(7), 220; https://doi.org/10.3390/toxins8070220

Impact of CDT Toxin on Human Diseases

Tiphanie Faïs 1,2,3,* , Julien Delmas 1,2,3, Arnaud Serres 2, Richard Bonnet 1,2,3 and Guillaume Dalmasso 1,2,3,*
Microbes, Inflammation, Intestin et Susceptibilité de l’Hôte (M2iSH), Clermont Université, Université d’Auvergne; INSERM U1071; INRA USC2018, Clermont-Ferrand 63000, France
Laboratoire de Bactériologie, Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France
Institut Universitaire de Technologie, Université d’Auvergne, Aubière 63170, France
Academic Editors: Joseph M. DiRienzo and Gerald E. Duhamel
Received: 10 February 2016 / Revised: 1 July 2016 / Accepted: 6 July 2016 / Published: 15 July 2016
(This article belongs to the Special Issue Contribution of Cytolethal Distending Toxin to Diseases Caused by Clinically-important Bacterial Pathogens)
Full-Text   |   PDF [1467 KB, uploaded 15 July 2016]   |


Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects. View Full-Text
Keywords: CDT toxin; CDT-producing bacteria; DNA damage CDT toxin; CDT-producing bacteria; DNA damage 

Faïs, T.; Delmas, J.; Serres, A.; Bonnet, R.; Dalmasso, G. Impact of CDT Toxin on Human Diseases. Toxins 2016, 8, 220.


Faïs T, Delmas J, Serres A, Bonnet R, Dalmasso G. Impact of CDT Toxin on Human Diseases. Toxins. 2016; 8(7):220.


Faïs, Tiphanie; Delmas, Julien; Serres, Arnaud; Bonnet, Richard; Dalmasso, Guillaume. 2016. "Impact of CDT Toxin on Human Diseases." Toxins 8, no. 7: 220.





