CT Chest Without and With IV Contrast There is no evidence to support screening in this population with chest CT without and with IV contrast. CT Chest Without IV Contrast Screening Screening for lung cancer is routinely performed with noncontrast LDCT in individuals who are eligible based on age and smoking history. LDCT for lung cancer screening is not currently useful for those without a significant smoking history. A retrospective study of 28,807 patients that included 12,176 who had not smoked; however, showed that LDCT helped to detect a significant number of lung cancers suggesting that more study is needed to evaluate screening in this population [38]. This study and others are part of a growing body of literature evaluating the use of lung cancer screening in patients without a history of smoking. In South Korea, 37,436 asymptomatic adults (17,968 without a smoking history and 19,468 with a smoking history) were screened for lung cancer using LDCT. The lung cancer rate was lower in those who had not smoked; however, no significant differences were seen in the number of false positives or the complication rates between the 2 groups [39]. There is particular interest in evaluating lung cancer in women, because the incidence of lung cancer in women without a significant smoking history is greater than in men [40,41]. In a retrospective study of 2,170 patients in the UK with lung cancer, the annual frequency of lung cancer development in those without a smoking history increased from 13% to 28%. Of those patients with lung cancer who had not smoked, 67% were women [42]. In a real-world cohort study of lung cancer screening in China, a total of 15,996 participants underwent LDCT. Among male patients with lung cancer in this study, 75% had a history of tobacco use. Among female patients with lung cancer in this cohort, only 5.8% reported a history of smoking [35].
Lung Cancer Screening PCAs. CT Chest Without and With IV Contrast There is no evidence to support screening in this population with chest CT without and with IV contrast. CT Chest Without IV Contrast Screening Screening for lung cancer is routinely performed with noncontrast LDCT in individuals who are eligible based on age and smoking history. LDCT for lung cancer screening is not currently useful for those without a significant smoking history. A retrospective study of 28,807 patients that included 12,176 who had not smoked; however, showed that LDCT helped to detect a significant number of lung cancers suggesting that more study is needed to evaluate screening in this population [38]. This study and others are part of a growing body of literature evaluating the use of lung cancer screening in patients without a history of smoking. In South Korea, 37,436 asymptomatic adults (17,968 without a smoking history and 19,468 with a smoking history) were screened for lung cancer using LDCT. The lung cancer rate was lower in those who had not smoked; however, no significant differences were seen in the number of false positives or the complication rates between the 2 groups [39]. There is particular interest in evaluating lung cancer in women, because the incidence of lung cancer in women without a significant smoking history is greater than in men [40,41]. In a retrospective study of 2,170 patients in the UK with lung cancer, the annual frequency of lung cancer development in those without a smoking history increased from 13% to 28%. Of those patients with lung cancer who had not smoked, 67% were women [42]. In a real-world cohort study of lung cancer screening in China, a total of 15,996 participants underwent LDCT. Among male patients with lung cancer in this study, 75% had a history of tobacco use. Among female patients with lung cancer in this cohort, only 5.8% reported a history of smoking [35].