 Although overall sensitivity of mammography is in the range of 70% to 85%, the sensitivity can vary significantly with breast density [5-7]. The mammographic sensitivity is higher in women with fatty breast parenchyma; however, the sensitivity may decrease to as low as 30% in women with dense breast tissue [5-9]. Although the overall performance of digital mammography is similar to film screen mammography, digital mammography has better performance in specific subgroups, such as in women with dense breasts [8,9]. In addition, even with regular mammographic screening, the interval cancer rate may be as high as 30% [10-13]. Given the limitations of mammography, supplemental screening has been advocated for women with dense breast tissue. In order to bring uniformity to the language, a federal law passed in February 2019, enables the FDA to develop a statement that the effect of breast density on mammographic sensitivity be included in all mammography report. aPerelman School of Medicine of the University of Pennsylvania, Philadelphia, PennsylvaniabPanel Chair, Boston University School of Medicine, Boston, Massachusetts. cPanel Vice-Chair, New York University School of Medicine, New York, New York. dBoston University Schools of Medicine and Public Health, Boston, Massachusetts. eYale School of Medicine, New Haven, Connecticut; Society of Surgical Oncology. fThomas Jefferson University Hospital, Robbinsville, New Jersey; American College of Obstetricians and Gynecologists. gAlpert Medical School of Brown University, Providence, Rhode Island. hFeinberg School of Medicine, Northwestern University, Chicago, Illinois; American College of Physicians. iUniversity of California San Francisco, San Francisco, California. jSutter Medical Group and Sutter Cancer Center, Roseville, California. kThe University of Texas MD Anderson Cancer Center, Houston, Texas. lEmory University Hospital, Atlanta, Georgia. mSanford Health of Northern Minnesota, Bemidji, Minnesota.
Supplemental Breast Cancer Screening Based on Breast Density.  Although overall sensitivity of mammography is in the range of 70% to 85%, the sensitivity can vary significantly with breast density [5-7]. The mammographic sensitivity is higher in women with fatty breast parenchyma; however, the sensitivity may decrease to as low as 30% in women with dense breast tissue [5-9]. Although the overall performance of digital mammography is similar to film screen mammography, digital mammography has better performance in specific subgroups, such as in women with dense breasts [8,9]. In addition, even with regular mammographic screening, the interval cancer rate may be as high as 30% [10-13]. Given the limitations of mammography, supplemental screening has been advocated for women with dense breast tissue. In order to bring uniformity to the language, a federal law passed in February 2019, enables the FDA to develop a statement that the effect of breast density on mammographic sensitivity be included in all mammography report. aPerelman School of Medicine of the University of Pennsylvania, Philadelphia, PennsylvaniabPanel Chair, Boston University School of Medicine, Boston, Massachusetts. cPanel Vice-Chair, New York University School of Medicine, New York, New York. dBoston University Schools of Medicine and Public Health, Boston, Massachusetts. eYale School of Medicine, New Haven, Connecticut; Society of Surgical Oncology. fThomas Jefferson University Hospital, Robbinsville, New Jersey; American College of Obstetricians and Gynecologists. gAlpert Medical School of Brown University, Providence, Rhode Island. hFeinberg School of Medicine, Northwestern University, Chicago, Illinois; American College of Physicians. iUniversity of California San Francisco, San Francisco, California. jSutter Medical Group and Sutter Cancer Center, Roseville, California. kThe University of Texas MD Anderson Cancer Center, Houston, Texas. lEmory University Hospital, Atlanta, Georgia. mSanford Health of Northern Minnesota, Bemidji, Minnesota.