fOttawa Hospital Research Institute and the Department of Radiology, The University of Ottawa, Ottawa, Ontario, Canada; Canadian Association of Radiologists. gUniversity of Kansas Medical Center, Kansas City, Kansas. hEinstein Healthcare Network, Philadelphia, Pennsylvania. iUniversity of California San Diego Medical Center, San Diego, California. jOregon Health & Science University, Portland, Oregon. kUniversity of North Carolina School of Medicine, Chapel Hill, North Carolina; American Academy of Neurology. lNorthwestern University Feinberg School of Medicine, Chicago, Neurosurgery Expert. mWalter Reed National Military Medical Center, Bethesda, Maryland. nUIC Medical Center, Chicago, Illinois; Neurosurgery Expert. oColumbia University Medical Center, New York, New York. pSpecialty Chair, Atlanta VA Health Care System and Emory University, Atlanta, Georgia. The American College of Radiology seeks and encourages collaboration with other organizations on the development of the ACR Appropriateness Criteria through society representation on expert panels. Participation by representatives from collaborating societies on the expert panel does not necessarily imply individual or society endorsement of the final document. Reprint requests to: publications@acr.org Movement Disorders and Neurodegenerative Diseases Human prion diseases, also known as transmissible spongiform encephalopathies, represent the most common cause of RPD and are a group of uniformly fatal neurodegenerative disorders associated with accumulation of a misfolded form of the normal prion protein. CJD is the most common human transmissible spongiform encephalopathy and can be either infectious or neurogenetic in nature. Four distinct types are currently recognized: sporadic, familial/genetic (mutations of the prion protein gene), iatrogenic, and variant.
Movement Disorders and Neurodegenerative Diseases. fOttawa Hospital Research Institute and the Department of Radiology, The University of Ottawa, Ottawa, Ontario, Canada; Canadian Association of Radiologists. gUniversity of Kansas Medical Center, Kansas City, Kansas. hEinstein Healthcare Network, Philadelphia, Pennsylvania. iUniversity of California San Diego Medical Center, San Diego, California. jOregon Health & Science University, Portland, Oregon. kUniversity of North Carolina School of Medicine, Chapel Hill, North Carolina; American Academy of Neurology. lNorthwestern University Feinberg School of Medicine, Chicago, Neurosurgery Expert. mWalter Reed National Military Medical Center, Bethesda, Maryland. nUIC Medical Center, Chicago, Illinois; Neurosurgery Expert. oColumbia University Medical Center, New York, New York. pSpecialty Chair, Atlanta VA Health Care System and Emory University, Atlanta, Georgia. The American College of Radiology seeks and encourages collaboration with other organizations on the development of the ACR Appropriateness Criteria through society representation on expert panels. Participation by representatives from collaborating societies on the expert panel does not necessarily imply individual or society endorsement of the final document. Reprint requests to: publications@acr.org Movement Disorders and Neurodegenerative Diseases Human prion diseases, also known as transmissible spongiform encephalopathies, represent the most common cause of RPD and are a group of uniformly fatal neurodegenerative disorders associated with accumulation of a misfolded form of the normal prion protein. CJD is the most common human transmissible spongiform encephalopathy and can be either infectious or neurogenetic in nature. Four distinct types are currently recognized: sporadic, familial/genetic (mutations of the prion protein gene), iatrogenic, and variant.