A review of 11 randomized trials and quasi-randomized trials looked at outcomes for US performed routinely versus selective US at <24 weeks. Although perinatal mortality was not affected, there was increased detection of fetal anomalies, improved detection of multiple gestations, and lower rates of induction for postdates. Long-term follow-up of children exposed to US in utero showed no detrimental effects on cognitive or physical development, supporting the safety of US [9]. There are several systematic reviews and large studies, which report fetal anomaly detection rates between 16% and 56% on US performed prior to 24 weeks [5,8,9]. The rate of detection of lethal anomalies is higher, up to 84% [8,29]. MRI Fetal Without and With IV Contrast There is no relevant literature to support the use of fetal MRI with and without intravenous (IV) contrast for screening of a fetal anomaly in a low-risk pregnancy. MRI Fetal Without IV Contrast There is no relevant literature to support the use of fetal MRI without IV contrast for screening of a fetal anomaly in a low-risk pregnancy. US Echocardiography Fetal There is no relevant literature to support the use of fetal echocardiography for screening of a fetal anomaly in a low- risk pregnancy. US Pregnant Uterus Transabdominal Detailed Scan There is no relevant literature to support the use of US pregnant uterus transabdominal detailed scan for screening of a fetal anomaly in a low-risk pregnancy. Second and Third Trimester Screening for Fetal Anomaly US Pregnant Uterus Transabdominal Anatomy Scan The Eunice Kennedy Shriver National Institute of Child Health and Human Development hosted a fetal imaging workshop in December 2012, resulting in a multispecialty panel recommending that at least one US be offered routinely to all pregnant women between 18 and 20 weeks of gestation [8].
Second and Third Trimester Screening for Fetal Anomaly. A review of 11 randomized trials and quasi-randomized trials looked at outcomes for US performed routinely versus selective US at <24 weeks. Although perinatal mortality was not affected, there was increased detection of fetal anomalies, improved detection of multiple gestations, and lower rates of induction for postdates. Long-term follow-up of children exposed to US in utero showed no detrimental effects on cognitive or physical development, supporting the safety of US [9]. There are several systematic reviews and large studies, which report fetal anomaly detection rates between 16% and 56% on US performed prior to 24 weeks [5,8,9]. The rate of detection of lethal anomalies is higher, up to 84% [8,29]. MRI Fetal Without and With IV Contrast There is no relevant literature to support the use of fetal MRI with and without intravenous (IV) contrast for screening of a fetal anomaly in a low-risk pregnancy. MRI Fetal Without IV Contrast There is no relevant literature to support the use of fetal MRI without IV contrast for screening of a fetal anomaly in a low-risk pregnancy. US Echocardiography Fetal There is no relevant literature to support the use of fetal echocardiography for screening of a fetal anomaly in a low- risk pregnancy. US Pregnant Uterus Transabdominal Detailed Scan There is no relevant literature to support the use of US pregnant uterus transabdominal detailed scan for screening of a fetal anomaly in a low-risk pregnancy. Second and Third Trimester Screening for Fetal Anomaly US Pregnant Uterus Transabdominal Anatomy Scan The Eunice Kennedy Shriver National Institute of Child Health and Human Development hosted a fetal imaging workshop in December 2012, resulting in a multispecialty panel recommending that at least one US be offered routinely to all pregnant women between 18 and 20 weeks of gestation [8].