Siderotic cardiomyopathy is characterized by iron deposition from frequent blood transfusions and altered iron hemostasis in hemoglobinopathy patients. Siderotic cardiomyopathy presents in advanced stages with HF, conduction abnormalities, or sudden death [2]. Scleroderma involves the heart in 80% (in autopsy) of cases, manifesting as HF, arrhythmia, CAD, peripheral vascular disease, or sudden death [2]. Endomyocardial fibrosis (Loeffler endocarditis in nontropical regions) is a spectrum of hyperesoinophlic syndrome (eosinophils >1,500/mm3; >6 months), with cardiac involvement seen in 50% of these patients [56]. There is an early necrotic phase followed by thrombotic and fibrotic phases. Myocardial oxalosis presents with LV thickening, heart block, and conduction abnormalities. Friedreich ataxia is characterized by mitochondrial iron accumulation, with cardiomyopathy seen in 63% of these patients [52]. Mucopolysaccharidoses has variable phenotypic expression. Infiltrative disease is generally evaluated with history, clinical examination, ECG, serology, and imaging tests [52]. Endomyocardial biopsy may be ultimately required for definitive diagnosis. Arteriography Coronary There is no relevant literature to support the use of coronary arteriography for the evaluation of restrictive cardiomyopathy. Arteriography Coronary with Ventriculography There is no relevant literature to support the use of coronary arteriography with ventriculography for infiltrative cardiac diseases. Right heart catheterization is used for the evaluation of hemodynamics, which is useful in the diagnosis of pulmonary hypertension and has prognostic value. In addition, right and left heart catheterization can be used to evaluate for constrictive pericarditis, which often has to be distinguished from restrictive cardiomyopathy. CT Chest There is no relevant literature to support the use of CT chest for evaluation of restrictive cardiomyopathy.
Nonischemic Myocardial Disease with Clinical Manifestations Ischemic Cardiomyopathy Already Excluded . Siderotic cardiomyopathy is characterized by iron deposition from frequent blood transfusions and altered iron hemostasis in hemoglobinopathy patients. Siderotic cardiomyopathy presents in advanced stages with HF, conduction abnormalities, or sudden death [2]. Scleroderma involves the heart in 80% (in autopsy) of cases, manifesting as HF, arrhythmia, CAD, peripheral vascular disease, or sudden death [2]. Endomyocardial fibrosis (Loeffler endocarditis in nontropical regions) is a spectrum of hyperesoinophlic syndrome (eosinophils >1,500/mm3; >6 months), with cardiac involvement seen in 50% of these patients [56]. There is an early necrotic phase followed by thrombotic and fibrotic phases. Myocardial oxalosis presents with LV thickening, heart block, and conduction abnormalities. Friedreich ataxia is characterized by mitochondrial iron accumulation, with cardiomyopathy seen in 63% of these patients [52]. Mucopolysaccharidoses has variable phenotypic expression. Infiltrative disease is generally evaluated with history, clinical examination, ECG, serology, and imaging tests [52]. Endomyocardial biopsy may be ultimately required for definitive diagnosis. Arteriography Coronary There is no relevant literature to support the use of coronary arteriography for the evaluation of restrictive cardiomyopathy. Arteriography Coronary with Ventriculography There is no relevant literature to support the use of coronary arteriography with ventriculography for infiltrative cardiac diseases. Right heart catheterization is used for the evaluation of hemodynamics, which is useful in the diagnosis of pulmonary hypertension and has prognostic value. In addition, right and left heart catheterization can be used to evaluate for constrictive pericarditis, which often has to be distinguished from restrictive cardiomyopathy. CT Chest There is no relevant literature to support the use of CT chest for evaluation of restrictive cardiomyopathy.