Liver Spleen Scan There is no relevant literature to support the use of a Tc-99m sulfur colloid scan in this clinical scenario. Liver Lesion-Initial Characterization US Abdomen In patients with a history of primary malignancy and indeterminate, subcentimeter focal liver lesions on CT, grayscale US is able to prove cystic nature of the lesion in 67% of cases [88]. US Abdomen with Contrast In patients with a history of primary malignancy and indeterminate, subcentimeter focal liver lesions on CT that were proven to be noncystic on grayscale US, CEUS correctly characterizes 95% of lesions overall, and 98% of metastases [88]. Compared with a baseline dual-phase contrast-enhanced CT, CEUS can detect 6.5 times more subcentimeter metastases [9]. CT of the abdomen with and without IV contrast is not recommended for this clinical scenario because there is no added value for unenhanced images. FDG-PET/CT Skull Base to Mid-Thigh There is no relevant literature to support the use of FDG-PET/CT in this clinical scenario. DOTATATE PET/CT Skull Base to Mid-Thigh There is no relevant literature to support the use of Ga-68-DOTATATE PET/CT in this clinical scenario. Octreotide Scan with SPECT or SPECT/CT Chest and Abdomen There is no relevant literature to support the use of In-111 somatostatin receptor scan with SPECT or SPECT/CT in this clinical scenario. There is no relevant literature that has assessed the performance of MRI without IV contrast specifically for this clinical scenario. Therefore, the committee recommendations on the use of MRI without IV contrast are based primarily on expert opinion. RBC Scan Abdomen and Pelvis There is no relevant literature to support the use of a Tc-99m RBC scan in this clinical scenario. Liver Spleen Scan There is no relevant literature to support the use of a Tc-99m sulfur colloid scan in this clinical scenario. Liver Lesion-Initial Characterization Liver Lesion-Initial Characterization
Liver Lesion Initial Characterization. Liver Spleen Scan There is no relevant literature to support the use of a Tc-99m sulfur colloid scan in this clinical scenario. Liver Lesion-Initial Characterization US Abdomen In patients with a history of primary malignancy and indeterminate, subcentimeter focal liver lesions on CT, grayscale US is able to prove cystic nature of the lesion in 67% of cases [88]. US Abdomen with Contrast In patients with a history of primary malignancy and indeterminate, subcentimeter focal liver lesions on CT that were proven to be noncystic on grayscale US, CEUS correctly characterizes 95% of lesions overall, and 98% of metastases [88]. Compared with a baseline dual-phase contrast-enhanced CT, CEUS can detect 6.5 times more subcentimeter metastases [9]. CT of the abdomen with and without IV contrast is not recommended for this clinical scenario because there is no added value for unenhanced images. FDG-PET/CT Skull Base to Mid-Thigh There is no relevant literature to support the use of FDG-PET/CT in this clinical scenario. DOTATATE PET/CT Skull Base to Mid-Thigh There is no relevant literature to support the use of Ga-68-DOTATATE PET/CT in this clinical scenario. Octreotide Scan with SPECT or SPECT/CT Chest and Abdomen There is no relevant literature to support the use of In-111 somatostatin receptor scan with SPECT or SPECT/CT in this clinical scenario. There is no relevant literature that has assessed the performance of MRI without IV contrast specifically for this clinical scenario. Therefore, the committee recommendations on the use of MRI without IV contrast are based primarily on expert opinion. RBC Scan Abdomen and Pelvis There is no relevant literature to support the use of a Tc-99m RBC scan in this clinical scenario. Liver Spleen Scan There is no relevant literature to support the use of a Tc-99m sulfur colloid scan in this clinical scenario. Liver Lesion-Initial Characterization Liver Lesion-Initial Characterization