Furthermore FDG-PET/CT has a high sensitivity and accuracy in detecting distant metastases, including osseous and pulmonary metastases [82,87,88], the most common sites for distant metastatic disease in NPC. Studies have shown that for early stage (I-II) disease, FDG-PET/CT may not confer additional benefit [74]. FDG-PET/CT is useful for the evaluation of metastatic cervical adenopathy with no primary evident on clinical examination or other imaging [17]. Comparison between FDG-PET/CT, CECT neck alone, or in combination with IV contrast-enhanced MRI, showed FDG-PET to be superior in detecting the primary site (69%) of the time versus 15% on CT alone and 41% when using the combination of CT and MRI [17]. FDG-PET/MRI Skull Base to Mid-Thigh FDG-PET/MRI is a new imaging modality with a growing body of evidence demonstrating the feasibility of use for routine clinical imaging, including the initial staging of NPC with similar results to FDG PET/CT [53,86]. A study found that this imaging modality may provide more accurate staging than the combination of FDG-PET/CT and MRI [89]. MRA Neck With IV Contrast There is no relevant literature to support the use of MRA neck with IV contrast in the initial staging of suspected or diagnosed NPC or EBV-associated unknown primary of the head and neck. MRA Neck Without and With IV Contrast There is no relevant literature to support the use of MRA neck without and with IV contrast in the initial staging of suspected or diagnosed NPC or EBV-associated unknown primary of the head and neck. MRA Neck Without IV Contrast There is no relevant literature to support the use of MRA neck without IV contrast in the initial staging of suspected or diagnosed NPC or EBV-associated unknown primary of the head and neck. MRI Head With IV Contrast There is no relevant literature to support the use of MRI head with IV contrast in the initial staging of suspected or diagnosed NPC or EBV-associated unknown primary of the head and neck.
Staging and Post Therapy Assessment of Head and Neck Cancer. Furthermore FDG-PET/CT has a high sensitivity and accuracy in detecting distant metastases, including osseous and pulmonary metastases [82,87,88], the most common sites for distant metastatic disease in NPC. Studies have shown that for early stage (I-II) disease, FDG-PET/CT may not confer additional benefit [74]. FDG-PET/CT is useful for the evaluation of metastatic cervical adenopathy with no primary evident on clinical examination or other imaging [17]. Comparison between FDG-PET/CT, CECT neck alone, or in combination with IV contrast-enhanced MRI, showed FDG-PET to be superior in detecting the primary site (69%) of the time versus 15% on CT alone and 41% when using the combination of CT and MRI [17]. FDG-PET/MRI Skull Base to Mid-Thigh FDG-PET/MRI is a new imaging modality with a growing body of evidence demonstrating the feasibility of use for routine clinical imaging, including the initial staging of NPC with similar results to FDG PET/CT [53,86]. A study found that this imaging modality may provide more accurate staging than the combination of FDG-PET/CT and MRI [89]. MRA Neck With IV Contrast There is no relevant literature to support the use of MRA neck with IV contrast in the initial staging of suspected or diagnosed NPC or EBV-associated unknown primary of the head and neck. MRA Neck Without and With IV Contrast There is no relevant literature to support the use of MRA neck without and with IV contrast in the initial staging of suspected or diagnosed NPC or EBV-associated unknown primary of the head and neck. MRA Neck Without IV Contrast There is no relevant literature to support the use of MRA neck without IV contrast in the initial staging of suspected or diagnosed NPC or EBV-associated unknown primary of the head and neck. MRI Head With IV Contrast There is no relevant literature to support the use of MRI head with IV contrast in the initial staging of suspected or diagnosed NPC or EBV-associated unknown primary of the head and neck.