MRI Breast Without IV Contrast Abbreviated There is no relevant literature regarding the use of AB-MRI breast without IV contrast for supplemental screening in high-risk women with dense breasts. MRI Breast Without and With IV Contrast Abbreviated AB-MRI performed with IV contrast is an abbreviated breast MRI examination. It is similar to a full MRI examination yet does not have a standard protocol; however, at minimum, it must include a precontrast and one postcontrast sequence. A T2-weighted sequence may also be included. There is limited relevant literature regarding the use of AB-MRI breast without and with IV contrast in high-risk women with dense breasts. In 2 retrospective studies comparing the full diagnostic protocol to an abbreviated protocol in high-risk women, the authors found both protocols to have similar sensitivity [48,49]. However, neither study evaluated the CDR by breast density. MRI Breast Without IV Contrast There is no relevant literature regarding the use of MRI breast without IV contrast for supplemental screening in high-risk women with dense breasts. MRI Breast Without and With IV Contrast The American Cancer Society advocates MRI screening in high-risk women regardless of breast density [15]. There is ample evidence in the literature supporting this recommendation [46,50-54]. In the high-risk population, sensitivity of mammography alone is approximately 31% to 33%, compared with the sensitivity of MRI alone which is 87% to 96% [45,46,55]. The combination of mammography and MRI yields 100% sensitivity compared with the 44% to 48% sensitivity of combined mammography and US [45,46]. In addition, the types of carcinoma detected on MRI compared with mammography may differ. Cancers detected on MRI are more likely to be invasive carcinomas (71%), whereas cancers detected on mammography were are likely to be ductal carcinoma in situ (65%), or associated with calcifications (88%) [56].
Supplemental Breast Cancer Screening Based on Breast Density. MRI Breast Without IV Contrast Abbreviated There is no relevant literature regarding the use of AB-MRI breast without IV contrast for supplemental screening in high-risk women with dense breasts. MRI Breast Without and With IV Contrast Abbreviated AB-MRI performed with IV contrast is an abbreviated breast MRI examination. It is similar to a full MRI examination yet does not have a standard protocol; however, at minimum, it must include a precontrast and one postcontrast sequence. A T2-weighted sequence may also be included. There is limited relevant literature regarding the use of AB-MRI breast without and with IV contrast in high-risk women with dense breasts. In 2 retrospective studies comparing the full diagnostic protocol to an abbreviated protocol in high-risk women, the authors found both protocols to have similar sensitivity [48,49]. However, neither study evaluated the CDR by breast density. MRI Breast Without IV Contrast There is no relevant literature regarding the use of MRI breast without IV contrast for supplemental screening in high-risk women with dense breasts. MRI Breast Without and With IV Contrast The American Cancer Society advocates MRI screening in high-risk women regardless of breast density [15]. There is ample evidence in the literature supporting this recommendation [46,50-54]. In the high-risk population, sensitivity of mammography alone is approximately 31% to 33%, compared with the sensitivity of MRI alone which is 87% to 96% [45,46,55]. The combination of mammography and MRI yields 100% sensitivity compared with the 44% to 48% sensitivity of combined mammography and US [45,46]. In addition, the types of carcinoma detected on MRI compared with mammography may differ. Cancers detected on MRI are more likely to be invasive carcinomas (71%), whereas cancers detected on mammography were are likely to be ductal carcinoma in situ (65%), or associated with calcifications (88%) [56].