The ACR recommends annual breast MRI in high-risk women beginning as early as 25 years of age [3]. Female Breast Cancer Screening MRI Breast Without and With IV Contrast Abbreviated Data are limited regarding the use of abbreviated breast MRI without and with IV contrast for screening in high- risk women. Following the publication of the American Cancer Society guidelines for supplemental screening breast MRI in 2007, high-risk women have traditionally undergone conventional full protocol breast MRI without and with IV contrast [3,4]. However, multiple studies have demonstrated similar diagnostic accuracy for abbreviated protocol MRI compared to conventional full protocol breast MRI [73-75]. In a study evaluating 3,037 abbreviated breast MRI in 1,975 high-risk women, the CDR was 29 per 1,000, the interval cancer rate was 0.66 per 1,000, and all cancers missed by abbreviated breast MRI were node negative early-stage invasive malignancies [72]. MRI Breast Without IV Contrast There is no relevant literature to support the use of MRI without IV contrast for screening women at high risk. MRI Breast Without IV Contrast Abbreviated There is no relevant literature to support the use of abbreviated breast MRI without IV contrast for screening women at high risk. Sestamibi MBI Data are limited regarding the use of sestamibi MBI for screening women at high risk. Most studies have focused upon women with dense breasts and variable risk profiles. Retrospective and prospective studies have demonstrated similar incremental CDR for sestamibi MBI of 6.5 to 9 over mammography, with one study demonstrating an incremental CDR of 16.5 per 1,000 in women at increased risk primarily due to family or personal history of breast cancer [40,47]. Sestamibi MBI demonstrates similar sensitivity, better specificity, and lower recall rate compared to supplemental screening US in women with dense breasts [47,48].
Female Breast Cancer Screening. The ACR recommends annual breast MRI in high-risk women beginning as early as 25 years of age [3]. Female Breast Cancer Screening MRI Breast Without and With IV Contrast Abbreviated Data are limited regarding the use of abbreviated breast MRI without and with IV contrast for screening in high- risk women. Following the publication of the American Cancer Society guidelines for supplemental screening breast MRI in 2007, high-risk women have traditionally undergone conventional full protocol breast MRI without and with IV contrast [3,4]. However, multiple studies have demonstrated similar diagnostic accuracy for abbreviated protocol MRI compared to conventional full protocol breast MRI [73-75]. In a study evaluating 3,037 abbreviated breast MRI in 1,975 high-risk women, the CDR was 29 per 1,000, the interval cancer rate was 0.66 per 1,000, and all cancers missed by abbreviated breast MRI were node negative early-stage invasive malignancies [72]. MRI Breast Without IV Contrast There is no relevant literature to support the use of MRI without IV contrast for screening women at high risk. MRI Breast Without IV Contrast Abbreviated There is no relevant literature to support the use of abbreviated breast MRI without IV contrast for screening women at high risk. Sestamibi MBI Data are limited regarding the use of sestamibi MBI for screening women at high risk. Most studies have focused upon women with dense breasts and variable risk profiles. Retrospective and prospective studies have demonstrated similar incremental CDR for sestamibi MBI of 6.5 to 9 over mammography, with one study demonstrating an incremental CDR of 16.5 per 1,000 in women at increased risk primarily due to family or personal history of breast cancer [40,47]. Sestamibi MBI demonstrates similar sensitivity, better specificity, and lower recall rate compared to supplemental screening US in women with dense breasts [47,48].