MRI Breast Without IV Contrast Abbreviated There is no relevant literature regarding the use of AB-MRI breast without IV contrast for supplemental screening in intermediate-risk women with nondense breasts. MRI Breast Without and With IV Contrast Abbreviated AB-MRI performed with IV contrast is an abbreviated breast MRI examination. It is similar to a full MRI examination yet does not have a standard protocol; however, at minimum, it must include a precontrast and one postcontrast sequence. A T2-weighted sequence may also be included. There are currently limited data on screening women with nondense breasts at intermediate lifetime risk with AB-MRI. In 2 retrospective reader studies, in women recently diagnosed with unifocal breast cancer, the sensitivity of AB-MRI was comparable with the full protocol [36,37]. When the performance of AB-MRI was compared with screening US and mammography, there were 12 cancers in 12 women (CDR 15/1,000), 7 of which were not detected on WBUS and mammography [38]. In a prospective observational study of 443 women with mild to moderately elevated lifetime risk for breast cancer, AB-MRI had a similar diagnostic accuracy as the full MRI protocol [39]. MRI Breast Without IV Contrast There is no relevant literature regarding the use of MRI breast without IV contrast for supplemental screening in intermediate-risk women with nondense breasts. MRI Breast Without and With IV Contrast There is some relevant literature supporting the use of MRI breast without and with IV contrast for supplemental screening in intermediate-risk women, specifically in women with a history of lobular carcinoma in situ or a personal history of breast cancer, although these studies included all breast densities [40-42].
Supplemental Breast Cancer Screening Based on Breast Density. MRI Breast Without IV Contrast Abbreviated There is no relevant literature regarding the use of AB-MRI breast without IV contrast for supplemental screening in intermediate-risk women with nondense breasts. MRI Breast Without and With IV Contrast Abbreviated AB-MRI performed with IV contrast is an abbreviated breast MRI examination. It is similar to a full MRI examination yet does not have a standard protocol; however, at minimum, it must include a precontrast and one postcontrast sequence. A T2-weighted sequence may also be included. There are currently limited data on screening women with nondense breasts at intermediate lifetime risk with AB-MRI. In 2 retrospective reader studies, in women recently diagnosed with unifocal breast cancer, the sensitivity of AB-MRI was comparable with the full protocol [36,37]. When the performance of AB-MRI was compared with screening US and mammography, there were 12 cancers in 12 women (CDR 15/1,000), 7 of which were not detected on WBUS and mammography [38]. In a prospective observational study of 443 women with mild to moderately elevated lifetime risk for breast cancer, AB-MRI had a similar diagnostic accuracy as the full MRI protocol [39]. MRI Breast Without IV Contrast There is no relevant literature regarding the use of MRI breast without IV contrast for supplemental screening in intermediate-risk women with nondense breasts. MRI Breast Without and With IV Contrast There is some relevant literature supporting the use of MRI breast without and with IV contrast for supplemental screening in intermediate-risk women, specifically in women with a history of lobular carcinoma in situ or a personal history of breast cancer, although these studies included all breast densities [40-42].