CT Chest, Abdomen, and Pelvis With IV Contrast Staging of patients before and after treatment typically entails either 1) FDG-PET/CT skull base to mid-thigh only or 2) bone scan in conjunction with CT chest, abdomen, and pelvis with IV contrast, depending upon institutional preference. There is no evidence to support performing all 3 studies. CT with IV contrast is commonly used to stage patients with newly diagnosed, locally advanced, or recurrent breast cancer [128]. PET/CT combines cross-sectional imaging with tumor metabolism and has been shown to be more sensitive and accurate than conventional staging with combined CT and bone scan [127]. CT Chest, Abdomen, and Pelvis Without and With IV Contrast There is no relevant literature to support the use of CT chest, abdomen, and pelvis without and with IV contrast in the initial evaluation of metastatic disease. CT Chest, Abdomen, and Pelvis Without IV Contrast There is no relevant literature to support the use of CT chest, abdomen, and pelvis without IV contrast in the initial evaluation of metastatic disease. FDG-PET/CT Skull Base to Mid-Thigh Staging of patients before and after treatment typically entails either 1) FDG-PET/CT skull base to mid-thigh only or 2) bone scan in conjunction with CT chest, abdomen, and pelvis with IV contrast, depending upon institutional preference. There is no evidence to support performing all 3 studies. PET/CT combines cross-sectional imaging with tumor metabolism and has been shown to be more sensitive and accurate than conventional staging with combined CT and bone scan [127]. Staging with PET/CT detects distant metastases with a sensitivity of 50% to 100% and a specificity of 50% to 97% in patients with advanced breast cancers, some of which were occult on conventional CT imaging. In one study by Lee et al, the detection of distant metastases occult on conventional CT imaging led to changes in clinical stage for 52% of women [129].
Monitoring Response to Neoadjuvant Systemic Therapy for Breast Cancer. CT Chest, Abdomen, and Pelvis With IV Contrast Staging of patients before and after treatment typically entails either 1) FDG-PET/CT skull base to mid-thigh only or 2) bone scan in conjunction with CT chest, abdomen, and pelvis with IV contrast, depending upon institutional preference. There is no evidence to support performing all 3 studies. CT with IV contrast is commonly used to stage patients with newly diagnosed, locally advanced, or recurrent breast cancer [128]. PET/CT combines cross-sectional imaging with tumor metabolism and has been shown to be more sensitive and accurate than conventional staging with combined CT and bone scan [127]. CT Chest, Abdomen, and Pelvis Without and With IV Contrast There is no relevant literature to support the use of CT chest, abdomen, and pelvis without and with IV contrast in the initial evaluation of metastatic disease. CT Chest, Abdomen, and Pelvis Without IV Contrast There is no relevant literature to support the use of CT chest, abdomen, and pelvis without IV contrast in the initial evaluation of metastatic disease. FDG-PET/CT Skull Base to Mid-Thigh Staging of patients before and after treatment typically entails either 1) FDG-PET/CT skull base to mid-thigh only or 2) bone scan in conjunction with CT chest, abdomen, and pelvis with IV contrast, depending upon institutional preference. There is no evidence to support performing all 3 studies. PET/CT combines cross-sectional imaging with tumor metabolism and has been shown to be more sensitive and accurate than conventional staging with combined CT and bone scan [127]. Staging with PET/CT detects distant metastases with a sensitivity of 50% to 100% and a specificity of 50% to 97% in patients with advanced breast cancers, some of which were occult on conventional CT imaging. In one study by Lee et al, the detection of distant metastases occult on conventional CT imaging led to changes in clinical stage for 52% of women [129].