001), and women were followed-up more frequently than men (P < . 001). In the multivariate analysis adjusted by age, smoking status, chronic obstructive pulmonary disease, and nodule characteristics, women were still more likely than men to be followed-up (P = . 002). The median time between nodule detection and those diagnosed with lung cancer was 1.5 months for men and 4.2 months for women (no statistical difference). Authors raise the question that management variability could be related to a false belief that lung cancer is considered a disease of men. This was a small study, and further research exploring management differences are warranted to better understand the impact of sex in the management of lung nodules. Vascularity differences between benign and malignant nodules have been described showing that malignant nodules are more vascular [30]. Nodule enhancement, which reflects vascularity, can be quantified with dynamic contrast- enhanced CT. This technique is highly sensitive in detecting malignant nodules but is nonspecific, mainly because of active inflammatory and infectious nodules also showing high vascularity [2,28]. Different enhancement cut-off values have been proposed to help with this problem. Lower cut-offs generally come with higher sensitivity but decreased specificity. Perfusion values are also influenced by technique, highlighting the need to be cautious when generalizing study results [34]. Incidentally Detected Indeterminate Pulmonary Nodule selection bias. Radiation dose was also discussed, suggesting their technique might not be appropriate for women with low pretest probability of malignancy [29]. Several other series have reported low specificity values [2,32]. Although enhancement patterns of solid nodules have been widely studied, this is not the case for part-solid nodules.
Incidentally Detected Indeterminate Pulmonary Nodule PCAs. 001), and women were followed-up more frequently than men (P < . 001). In the multivariate analysis adjusted by age, smoking status, chronic obstructive pulmonary disease, and nodule characteristics, women were still more likely than men to be followed-up (P = . 002). The median time between nodule detection and those diagnosed with lung cancer was 1.5 months for men and 4.2 months for women (no statistical difference). Authors raise the question that management variability could be related to a false belief that lung cancer is considered a disease of men. This was a small study, and further research exploring management differences are warranted to better understand the impact of sex in the management of lung nodules. Vascularity differences between benign and malignant nodules have been described showing that malignant nodules are more vascular [30]. Nodule enhancement, which reflects vascularity, can be quantified with dynamic contrast- enhanced CT. This technique is highly sensitive in detecting malignant nodules but is nonspecific, mainly because of active inflammatory and infectious nodules also showing high vascularity [2,28]. Different enhancement cut-off values have been proposed to help with this problem. Lower cut-offs generally come with higher sensitivity but decreased specificity. Perfusion values are also influenced by technique, highlighting the need to be cautious when generalizing study results [34]. Incidentally Detected Indeterminate Pulmonary Nodule selection bias. Radiation dose was also discussed, suggesting their technique might not be appropriate for women with low pretest probability of malignancy [29]. Several other series have reported low specificity values [2,32]. Although enhancement patterns of solid nodules have been widely studied, this is not the case for part-solid nodules.