Because screening mammography decreases breast cancer mortality, screening Female Breast Cancer Screening mammography or screening DBT is still performed in women undergoing supplemental screening studies [3,8,35]. Rather than supplementing screening mammography with additional imaging modalities, some have suggested limiting women offered screening mammography based upon individual patient risk assessed by various risk models, breast density, or genetic information such as single-nucleotide polymorphism. However, the randomized controlled trials demonstrating mortality reduction and most large-scale observational studies enrolled women based upon age and geographic location, not individual patient risk factors. In one observational study in women <50 years of age, restricting screening to women with a first-degree family history, extremely dense breast tissue, or both, would cause 66% of potentially screen-detected cancers to be missed [41]. Numerous studies in high-risk women have evaluated the performance of mammography and supplemental screening modalities, such as US and MRI. Mammography consistently demonstrates lower sensitivity (25%-69%) than US or MRI, and high-risk women experience higher interval cancer rates than the general population [3,40]. The combination of mammography with MRI yields the highest sensitivity across high-risk groups of women (91%- 98%) [3,40,81]. Because screening mammography decreases breast cancer mortality, screening mammography or screening DBT is still performed in women undergoing supplemental screening studies [3,8,35]. High-risk women should begin annual screening mammography at 30 years of age or 10 years prior to the youngest family member who had breast cancer, but generally not before 30 years of age [3]. Approximately one-third of breast cancers may only be detected on mammography in BRCA2 mutation carriers who are <40 years of age [79].
Female Breast Cancer Screening. Because screening mammography decreases breast cancer mortality, screening Female Breast Cancer Screening mammography or screening DBT is still performed in women undergoing supplemental screening studies [3,8,35]. Rather than supplementing screening mammography with additional imaging modalities, some have suggested limiting women offered screening mammography based upon individual patient risk assessed by various risk models, breast density, or genetic information such as single-nucleotide polymorphism. However, the randomized controlled trials demonstrating mortality reduction and most large-scale observational studies enrolled women based upon age and geographic location, not individual patient risk factors. In one observational study in women <50 years of age, restricting screening to women with a first-degree family history, extremely dense breast tissue, or both, would cause 66% of potentially screen-detected cancers to be missed [41]. Numerous studies in high-risk women have evaluated the performance of mammography and supplemental screening modalities, such as US and MRI. Mammography consistently demonstrates lower sensitivity (25%-69%) than US or MRI, and high-risk women experience higher interval cancer rates than the general population [3,40]. The combination of mammography with MRI yields the highest sensitivity across high-risk groups of women (91%- 98%) [3,40,81]. Because screening mammography decreases breast cancer mortality, screening mammography or screening DBT is still performed in women undergoing supplemental screening studies [3,8,35]. High-risk women should begin annual screening mammography at 30 years of age or 10 years prior to the youngest family member who had breast cancer, but generally not before 30 years of age [3]. Approximately one-third of breast cancers may only be detected on mammography in BRCA2 mutation carriers who are <40 years of age [79].