In this study, only 9.2% of individuals met the 2021 USPSTF lung cancer screening eligibility criteria. Among male patients with lung cancer, 23.2% were <50 years of age. In female patients with lung cancer, 33.3% were <50 years of age [35]. This study suggests that further evaluation of screening may be warranted in younger individuals, although more research is needed to assess the utility of screening in this population. Several studies have evaluated LDCT in patients with occupational exposures. In a cohort of 2,433 men exposed to asbestos, both lung cancer-related mortality and all-cause mortality was reduced amongst participants who underwent lung cancer screening [36]. A separate cohort study of LDCT among 7,189 nuclear weapons workers also demonstrated favorable results, detecting 80 lung cancers, of which 59% were stage I and an additional 10% were stage II [37]. As with the populations above, additional investigation is needed to assess screening in individuals with occupational exposures. FDG-PET/CT Skull Base to Mid-Thigh There is no evidence to support screening in this population with FDG-PET/CT. MRI Chest Without and With IV Contrast There is no evidence to support screening in this population with MRI chest without and with IV contrast. MRI Chest Without IV Contrast There is no evidence to support screening in this population with MRI chest without IV contrast. Radiography Chest There is no evidence to support screening in this population with chest radiography. Variant 3: Lung cancer screening. Patient of any age with less than 20 packs per year history of smoking, and no additional risk factor (ie, radon exposure or occupational exposure or cancer history or family history of lung cancer or history of COPD or history of pulmonary fibrosis). Initial imaging. CT Chest With IV Contrast There is no evidence to support screening in this population with chest CT with IV contrast. Lung Cancer Screening
Lung Cancer Screening PCAs. In this study, only 9.2% of individuals met the 2021 USPSTF lung cancer screening eligibility criteria. Among male patients with lung cancer, 23.2% were <50 years of age. In female patients with lung cancer, 33.3% were <50 years of age [35]. This study suggests that further evaluation of screening may be warranted in younger individuals, although more research is needed to assess the utility of screening in this population. Several studies have evaluated LDCT in patients with occupational exposures. In a cohort of 2,433 men exposed to asbestos, both lung cancer-related mortality and all-cause mortality was reduced amongst participants who underwent lung cancer screening [36]. A separate cohort study of LDCT among 7,189 nuclear weapons workers also demonstrated favorable results, detecting 80 lung cancers, of which 59% were stage I and an additional 10% were stage II [37]. As with the populations above, additional investigation is needed to assess screening in individuals with occupational exposures. FDG-PET/CT Skull Base to Mid-Thigh There is no evidence to support screening in this population with FDG-PET/CT. MRI Chest Without and With IV Contrast There is no evidence to support screening in this population with MRI chest without and with IV contrast. MRI Chest Without IV Contrast There is no evidence to support screening in this population with MRI chest without IV contrast. Radiography Chest There is no evidence to support screening in this population with chest radiography. Variant 3: Lung cancer screening. Patient of any age with less than 20 packs per year history of smoking, and no additional risk factor (ie, radon exposure or occupational exposure or cancer history or family history of lung cancer or history of COPD or history of pulmonary fibrosis). Initial imaging. CT Chest With IV Contrast There is no evidence to support screening in this population with chest CT with IV contrast. Lung Cancer Screening