MRI-Targeted Biopsy Prostatectomy Bed Similar to the greatly increased yields of targeted biopsy informed by targets identified on MRI in initial prostate cancer detection, biopsy in the setting of BCR is much more likely to identify a local recurrence when done targeting a suspicious lesion identified by MRI rather than systematic biopsy of the operative bed. In this setting, Post-Treatment Follow-up of Prostate Cancer it is the prostatectomy bed rather than the prostate itself. Because there is no commercial targeting application available in the postprostatectomy setting (there is no gland to segment), these targeted biopsies must be done with cognitive fusion or in-bore targeting [10]. Candidacy for salvage local therapy is largely determined by identification and characterization of a treatable local recurrence by biopsy. TRUS Prostatectomy Bed Several studies have shown the usefulness of color and power Doppler and contrast-enhanced color Doppler in detecting local recurrence after prostatectomy [19,42,43]. Choline PET/MRI Skull base to Mid-Thigh PET/MRI is a relatively newer imaging modality that allows simultaneous anatomic, functional, and molecular imaging of body parts. Few studies have evaluated the use of choline in PET/MRI. In 1 study with 75 patients with BCR, choline PET/MRI had a higher cancer detection rate compared with choline PET/CT (84.7% versus 77.3%) [58]. Fluciclovine PET/CT Skull Base to Mid-Thigh Fluciclovine (also known as anti-1-amino-3-[18-F]-fluorocyclobutane-1-carboxylic acid [FACBC]) is a synthetic amino acid PET radiotracer that was FDA approved in May 2016 for the imaging of patients with suspected prostate cancer recurrence based on elevated serum PSA levels following prior treatment. Odewole et al [59] reported superiority to 111 indium-capromab pendetide and to CT with detection of nodes as small as 5 mm and upstaging 25.7% of patients.
Post Treatment Follow up of Prostate Cancer. MRI-Targeted Biopsy Prostatectomy Bed Similar to the greatly increased yields of targeted biopsy informed by targets identified on MRI in initial prostate cancer detection, biopsy in the setting of BCR is much more likely to identify a local recurrence when done targeting a suspicious lesion identified by MRI rather than systematic biopsy of the operative bed. In this setting, Post-Treatment Follow-up of Prostate Cancer it is the prostatectomy bed rather than the prostate itself. Because there is no commercial targeting application available in the postprostatectomy setting (there is no gland to segment), these targeted biopsies must be done with cognitive fusion or in-bore targeting [10]. Candidacy for salvage local therapy is largely determined by identification and characterization of a treatable local recurrence by biopsy. TRUS Prostatectomy Bed Several studies have shown the usefulness of color and power Doppler and contrast-enhanced color Doppler in detecting local recurrence after prostatectomy [19,42,43]. Choline PET/MRI Skull base to Mid-Thigh PET/MRI is a relatively newer imaging modality that allows simultaneous anatomic, functional, and molecular imaging of body parts. Few studies have evaluated the use of choline in PET/MRI. In 1 study with 75 patients with BCR, choline PET/MRI had a higher cancer detection rate compared with choline PET/CT (84.7% versus 77.3%) [58]. Fluciclovine PET/CT Skull Base to Mid-Thigh Fluciclovine (also known as anti-1-amino-3-[18-F]-fluorocyclobutane-1-carboxylic acid [FACBC]) is a synthetic amino acid PET radiotracer that was FDA approved in May 2016 for the imaging of patients with suspected prostate cancer recurrence based on elevated serum PSA levels following prior treatment. Odewole et al [59] reported superiority to 111 indium-capromab pendetide and to CT with detection of nodes as small as 5 mm and upstaging 25.7% of patients.