A retrospective single-institution study of 152 patients with soft tissue sarcomas comparing whole body FDG- PET/CT with MRI at the primary treatment site did not detect a significant difference in performance for detecting local recurrence (MRI sensitivity of 90% and specificity of 98%, compared with FDG-PET/CT sensitivity of 95% and specificity of 96%) [80]. FDG-PET/MRI Whole Body A retrospective single-institution study of 41 patients with resected soft tissue sarcomas and with clinically suspicious recurrence underwent FDG-PET/MRI, either whole body if a truncal primary or localized to the primary tumor site if an extremity sarcoma. The MRI portion and then FDG-PET/MRI portions were interpreted independently. With the addition of FDG-PET imaging to the MRI, sensitivity increased from 82% to 96%, although specificity mildly decreased from 85% to 79%. Diagnostic confidence increased for the readers [81]. FDG- PET/MRI whole body may be useful as a problem-solving tool when other imaging of the area of interest is equivocal. MRI Area of Interest Without and With IV Contrast MRI used as surveillance of the primary soft tissue tumor site is the mainstay for evaluating local recurrence. Few studies regarding the diagnostic utility of MRI for local recurrence of soft tissue sarcomas have been published in recent years, likely given its widespread adoption clinically. MRI is useful not only for asymptomatic surveillance but also if a clinical area of concern at the resection site develops. MRI is often requested before surgery and radiation when local recurrence is established. A retrospective single-institution study by Park et al [77] of 325 patients with extremity sarcoma with a local recurrence rate of 11% found MRI detected 60% of those patients with recurrence not identified clinically or with US. Those with MRI detected local recurrence trended towards better survival, but this did not reach statistical significance.
Malignant or Aggressive Primary Musculoskeletal Tumor Staging And Surveillance PCAs. A retrospective single-institution study of 152 patients with soft tissue sarcomas comparing whole body FDG- PET/CT with MRI at the primary treatment site did not detect a significant difference in performance for detecting local recurrence (MRI sensitivity of 90% and specificity of 98%, compared with FDG-PET/CT sensitivity of 95% and specificity of 96%) [80]. FDG-PET/MRI Whole Body A retrospective single-institution study of 41 patients with resected soft tissue sarcomas and with clinically suspicious recurrence underwent FDG-PET/MRI, either whole body if a truncal primary or localized to the primary tumor site if an extremity sarcoma. The MRI portion and then FDG-PET/MRI portions were interpreted independently. With the addition of FDG-PET imaging to the MRI, sensitivity increased from 82% to 96%, although specificity mildly decreased from 85% to 79%. Diagnostic confidence increased for the readers [81]. FDG- PET/MRI whole body may be useful as a problem-solving tool when other imaging of the area of interest is equivocal. MRI Area of Interest Without and With IV Contrast MRI used as surveillance of the primary soft tissue tumor site is the mainstay for evaluating local recurrence. Few studies regarding the diagnostic utility of MRI for local recurrence of soft tissue sarcomas have been published in recent years, likely given its widespread adoption clinically. MRI is useful not only for asymptomatic surveillance but also if a clinical area of concern at the resection site develops. MRI is often requested before surgery and radiation when local recurrence is established. A retrospective single-institution study by Park et al [77] of 325 patients with extremity sarcoma with a local recurrence rate of 11% found MRI detected 60% of those patients with recurrence not identified clinically or with US. Those with MRI detected local recurrence trended towards better survival, but this did not reach statistical significance.