Digital Breast Tomosynthesis Diagnostic Although there is no relevant literature to support the use of DBT alone in assessing nipple discharge, mammography is useful for evaluating pathologic nipple discharge in male and female patients in this age group [30]. Early studies with DBT demonstrate promise in assessing the symptomatic breast [35,36]. Evaluation of Nipple Discharge US Breast Yue et al [69] studied 955 women <25 years of age who presented with breast symptoms including palpable mass, pain, and nipple discharge. US was performed in 692 patients and was normal/negative in 671 patients and indeterminate in 21 patients. No cancer was found in this group via biopsy or clinical follow-up. However, it is unknown how many of these patients had pathologic or physiologic discharge. Ductography There is no relevant literature to support the use of ductography in women <30 years of age with symptoms of pathologic nipple discharge. MRI Breast There is no relevant literature to support the use of MRI in women <30 years of age with symptoms of pathologic nipple discharge. FDG-PET Breast Dedicated There is no relevant literature to support the use of FDG-PET in women <30 years of age with symptoms of pathologic nipple discharge. Image-guided Core Biopsy Breast There is no relevant literature to support the use of image-guided core biopsy in women <30 years of age with symptoms of pathologic nipple discharge. However, if an imaging abnormality is identified, US may be used to direct biopsy. Image-Guided Fine Needle Aspiration Breast There is no relevant literature to support the use of image-guided FNA in women <30 years of age with symptoms of pathologic nipple discharge. Sestamibi MBI There is no relevant literature to support the use of MBI in women <30 years of age with symptoms of pathologic nipple discharge.
Evaluation of Nipple Discharge. Digital Breast Tomosynthesis Diagnostic Although there is no relevant literature to support the use of DBT alone in assessing nipple discharge, mammography is useful for evaluating pathologic nipple discharge in male and female patients in this age group [30]. Early studies with DBT demonstrate promise in assessing the symptomatic breast [35,36]. Evaluation of Nipple Discharge US Breast Yue et al [69] studied 955 women <25 years of age who presented with breast symptoms including palpable mass, pain, and nipple discharge. US was performed in 692 patients and was normal/negative in 671 patients and indeterminate in 21 patients. No cancer was found in this group via biopsy or clinical follow-up. However, it is unknown how many of these patients had pathologic or physiologic discharge. Ductography There is no relevant literature to support the use of ductography in women <30 years of age with symptoms of pathologic nipple discharge. MRI Breast There is no relevant literature to support the use of MRI in women <30 years of age with symptoms of pathologic nipple discharge. FDG-PET Breast Dedicated There is no relevant literature to support the use of FDG-PET in women <30 years of age with symptoms of pathologic nipple discharge. Image-guided Core Biopsy Breast There is no relevant literature to support the use of image-guided core biopsy in women <30 years of age with symptoms of pathologic nipple discharge. However, if an imaging abnormality is identified, US may be used to direct biopsy. Image-Guided Fine Needle Aspiration Breast There is no relevant literature to support the use of image-guided FNA in women <30 years of age with symptoms of pathologic nipple discharge. Sestamibi MBI There is no relevant literature to support the use of MBI in women <30 years of age with symptoms of pathologic nipple discharge.