Another study comparing patients with history of proliferative lesions with atypia with matched screenings based on age, density, and breast cancer family history also found no differences in mammographic sensitivity or proportion of interval cancers; however, they also reported lower specificity in the atypical proliferative lesions group [19]. FDG-PET Breast Dedicated There is no relevant literature to support the use of fluorine-18-2-fluoro-2-deoxy-D-glucose (FDG)-PET breast imaging in this clinical scenario. Although there are no relevant studies examining mammographic follow-up intervals of benign breast disease following surgical biopsy, there are some studies examining imaging intervals following benign core biopsy. In populations with nonproliferative lesions or proliferative lesions without atypia, imaging intervals of 6 months compared with routine annual screening did not improve cancer detection rates or change invasive cancer rates, stage, tumor size, or nodal status [11,12]. The studies on proliferative lesions with atypia, examining the need for Imaging after Breast Surgery excision and, if not excised, the need for short interval follow-up, are varied [13-16,20] and are outside the scope of this document. A majority agree that there is a need for surgical excision when atypical ductal hyperplasia is found on core biopsy. There is more varied practice in management of atypical lobular hyperplasia, LCIS, and flat epithelial atypia found on core biopsy. One study of more than 2 million screening mammograms in nearly 800,000 women, with 15% having a self- reported history of prior benign percutaneous or excisional breast biopsy, showed no difference in mammographic sensitivity; however, there was decreased in specificity and mammographic performance, which was attributed to tissue characteristics rather than the biopsy itself [18].
Imaging after Breast Surgery. Another study comparing patients with history of proliferative lesions with atypia with matched screenings based on age, density, and breast cancer family history also found no differences in mammographic sensitivity or proportion of interval cancers; however, they also reported lower specificity in the atypical proliferative lesions group [19]. FDG-PET Breast Dedicated There is no relevant literature to support the use of fluorine-18-2-fluoro-2-deoxy-D-glucose (FDG)-PET breast imaging in this clinical scenario. Although there are no relevant studies examining mammographic follow-up intervals of benign breast disease following surgical biopsy, there are some studies examining imaging intervals following benign core biopsy. In populations with nonproliferative lesions or proliferative lesions without atypia, imaging intervals of 6 months compared with routine annual screening did not improve cancer detection rates or change invasive cancer rates, stage, tumor size, or nodal status [11,12]. The studies on proliferative lesions with atypia, examining the need for Imaging after Breast Surgery excision and, if not excised, the need for short interval follow-up, are varied [13-16,20] and are outside the scope of this document. A majority agree that there is a need for surgical excision when atypical ductal hyperplasia is found on core biopsy. There is more varied practice in management of atypical lobular hyperplasia, LCIS, and flat epithelial atypia found on core biopsy. One study of more than 2 million screening mammograms in nearly 800,000 women, with 15% having a self- reported history of prior benign percutaneous or excisional breast biopsy, showed no difference in mammographic sensitivity; however, there was decreased in specificity and mammographic performance, which was attributed to tissue characteristics rather than the biopsy itself [18].