DSC
DSC may refer to:

Academia
 D.Sc., Doctor of Science
 Dalton State College, Georgia
 Daytona State College, Florida
 Deep Springs College, California
 District Selection Committee
 Dixie State University, Utah
 Doctor of Surgical Chiropody, superseded in the 1960s by Doctor of Podiatric Medicine

Science and technology
 .dsc, filename extension for files with description of source package in Debian
 DECT Standard Cipher, an encryption algorithm used by wireless telephone systems
 Differential scanning calorimetry, or the differential scanning calorimeter
 Digital Selective Calling in marine telecommunications
 Digital setting circles on telescopes
 Digital Signal Controller, a hybrid microcontroller and digital signal processor
 Digital Still Camera, used in automatic numbering of files of certain manufacturers within the Design rule for Camera File system (DCF) standard
 Document Structuring Conventions in PostScript programming
 Distributed source coding, a technique regarding the compression of multiple correlated information sources that do not communicate with each other.
 Dye-sensitized solar cell
 Dynamic stability control, computerized technology that improves a vehicle's stability 
 Dynamic susceptibility contrast, a type of perfusion MRI
 Desired State Configuration, a feature of Windows PowerShell that enables the deployment and management of configuration data for systems 
 Display Stream Compression, a technique part of the VESA standard, used to lower the bandwidth used by a video signal
 Dice similarity coefficient
 A subarctic climate in Köppen climate classification

Government, politics and the military
 Defence Security Corps, Indian military agency
 Defense Security Command, South Korean military agency
 Distinguished Service Cross (Australia), Australian military award
 Distinguished Service Cross (United Kingdom), British naval award
 Distinguished Service Cross (United States), American military award
 United States District Court for the District of South Carolina
 Directory of Social Change, British charity

Media, sports and entertainment
 Daily Source Code, a podcast by Adam Curry
 Dave, Shelly, and Chainsaw, a long-running morning radio show in the San Diego, California area
 Dresdner SC, a German multisport club playing in Dresden, Saxony
 Dubai Sports City, a multi-venue sports complex in Dubai, United Arab Emirates
 Star Trek: Discovery, an American science fiction television series and part of the Star Trek franchise officially abbreviated to "DSC".
 U.S. Postal Service Pro Cycling Team (UCI code: DSC), a United States-based professional road bicycle racing team
 Dutch Swing College Band

Other
 Down Syndrome Centre, a registered charity in Ireland
 Democratic Socialists of Canada, Canadian political organization