Teledermatology protocol for screening of Skin Cancer
It is not difficult to see the potential that the dissemination of use of
telemedicine has to offer to the practice of Dermatology. Especially if we consider
that, in this branch of medicine, which is responsible for the care of the skin and
its adnexa, the diagnosis of patients is often made - with due respect to the
patient's medical history - through images and visualizations of the lesion. Thus,
one can say that teledermatology corresponds to the branch of telemedicine that
seeks to subsume new IT and communication technologies into dermatological
practices, in order to reduce the need for face-to-face encounter between the
patient and the specialist. Its objective is to ensure effective healthcare
planning, research, education, clinical discussion, second opinions and specialized
dermatological care. Because dermatology deals with a strong visual component, it is
highly benefited by telemedicine, which is basicly used to provide teleconsultation,
i.e., remote medical assistance. - There are two methods for the exchange of information in Telemedicine which are also
used in second formative opinion: the synchronous (realtime) mode, in which the
person asking the question and the one answering it, together with the patient,
participate in live consultations; and the asynchronous mode (store-and-forward), in
which a question is transferred to a database for later consultation. The latter
mode is used by the Santa Catarina Telemedicine Network (RCTM, Rede Catarinense de
Telemedicina). , - Due to the large number of dermatological diseases and their clinical and temporal
variability, and the difficulty in standardizing photos, the creation of specific
protocols and adequate tools for enabling remote diagnostics in dermatology is of
paramount importance. , - Currently, it is not difficult to realize that one of the main impediments to the
achievement of a comprehensive and effective healthcare system is economic. In this
sense, second formative opinion and telediagnosis offer alternatives to overcome
this barrier, since they are considered to be low-cost procedures, when compared to
the concrete results achieved. , Another remarkable fact is the maldistribution of physicians in the state of Santa
Catarina Most professionals, for many different reasons, tend to establish
themselves around urban centers, often leaving the outlying areas under the
responsibility of non-specialist professionals. In this context, the second
formative opinion is used with the objective of assessing the need for referral of a
patient to a specialist away from home. This prevents that simple therapeutic
treatments are put off due to the distance between patient and specialist.
Furthermore, this new technique for exchange of information allows the provision of
adequate treatment to residents of remote regions. , , , , An accurate diagnosis is crucial for a successful therapeutic intervention. However,
the dynamics of medicine as well as the various ways in which a disease can manifest
itself interferes with the art of clinical reasoning. Given this reality, added to
the economic and geographic factors outlined above, telediagnosis through
teledermatology appears as an innovative method of professional aid, essential to
enabling proper access to health. In this perspective, the verification of the effectiveness of telediagnosis in
dermatology proves extremely valuable for the consolidation of this new technique as
an alternative to achieve a democratic and specialized medical treatment. Thus, this study aims to determine the diagnostic compatibility between general
practitioners of primary healthcare services and telediagnosis in dermatology by a
specialist physicians. This should be done by using a structured protocol of
teledermatology for the diagnosis of the main types of skin cancer that affect the
population of Santa Catarina. 

This is an epidemiological case-control study to validate the structured protocol of
teledermatology for the diagnostic screening of skin cancer. A descriptive
cross-sectional approach was adopted for the independent variables. The study was
conducted at the Center for Telemedicine and Telehealth of the State Secretariat of
Health of Santa Catarina. The study population included patients treated in Basic Healthcare Units (BHU) of
Santa Catarina who sought treatment due to visible dermatological complaints. The physician who required the examination (assistant - non-specialist physician),
responsible for on-site consultations in Primary Health Care (PHC), and the
dermatologist responsible for remotely making the analysis and proposing a diagnosis
based on the photos of the lesions (telediagnosis) also participated in the study
. We used the census method to select the study population. Inclusion and exclusion criteria All patients - - regardless of age, gender, socioeconomic status, skin type or
origin - who sought a BHU in Santa Catarina with visible dermatological
complaints and after initial medical assessment with a nonspecialist were
referred for consultation with a dermatologist (specialist) via telediagnosis
were admitted to this study. However, only those who signed the informed consent
form participated in the study. Groups Cases: patients who presented with suspect lesions detected by the attending
primary care physician. Controls: patients who had lesions compatible with skin cancer according to the
specialist's assessment. Exclusion criteria were: patients who attended the consultation with
dermatological complaints, but had no visible lesions or who had lesions which
presented insufficient quality for evaluation or patients who were undergoing
dermatological treatment and presented only clinical symptoms without visible
dermatological symptoms. All those who did not sign the consent form were also
excluded from the study. Data collection Aiming at the standardization of procedures for the collection of data for this
study, which occurred by means of digital imaging, we provided trainings to the
professionals working at the nine healthcare centers which are evenly
distributed among the macro-regions that make up the State of Santa Catarina.
This space was called Qualified Healthcare Units for the Collection of Tests and
counted with the participation of professional technicians, previously trained
to obtaining adequate images. Procedures During on-site consultation with a non-specialist physician in the Basic
Healthcare Units, all relevant patient data were entered into an electronic
health record. This made a referral to a specialist possible, when needed.
Patients who had signs or symptoms that suggested skin cancer had indication of
referral. Those patients who were selected for a consultation with a dermatologist were
conducted to the nearest Qualified Healthcare Unit for the Collection of Tests,
where data collection was conducted once the consent form had been signed. The photographic record for the investigation of suspected cancer cases was
performed in three steps: Panoramic Photo, Close-up with scale and
Dermoscopy. Regarding the Panoramic Photo, the technician was instructed to identify each
lesion using a label with the date, patient's initials and lesion number. He
also was told to make a panoramic image of the region of the body affected by
one or more lesions (head, torso, arms and legs, either front or back). At this
stage, the technician was instructed not to use the zoom function. The second step consisted of close-up with scale. The technician was instructed
to take the picture at a distance of about thirty centimeters from the lesion,
without using the zoom function and to place a scale parallel to the lesion in
order to serve as a reference of the actual size of the lesion. Finally, the third photo was taken by using dermoscopy. The dermatoscope was
connected to the digital camera. In this step, the technician applied gel on the
lens of the camera and photographed each lesion by using the dermatoscope placed
against the patient's skin and the maximum zooming level. After collection, the data were transmitted through an environment developed
exclusively for sending data corresponding to each patient on the Internet.
Whenever a new case arrived, a message was sent to the participating physician
(specialist), communicating the new remote consultation request, which was
accessed through a restricted site. The doctor in charge would show his diagnosis autonomously, respecting the
seventy-two-hour deadline and using the clinical photographs and medical data
sent by the non-specialist physician. Data collection instrument A protocol was used as an instrument for data collection. It included information
relating to the procedure used for obtaining images of the lesions and the
anatomical region affected. After the protocol was completed, the photos were
sent via the Internet to a restricted virtual site, to which the remote
specialist (dermatologist) and the on-site non-specialist physician had
access. The collection of images was performed by using Cyber Shot cameras, since
photographs of lesions are part of the basic data necessary for conducting
telediagnosis. These images were then uploaded onto the computer via USB cable
and stored in JPEG format. Statistical analysis Data were analyzed using the SPSS 18.0 program. Sensitivity and specificity as
well as PPV and NPV, and accuracy of the diagnosis of each tumor type were
calculated. The odds that the medical expert could make a diagnosis for the
dermatological examination sent, following the established protocol or not, were
calculated by the odds ratio, considering the 95% confidence interval and
p<0.05. For validation, methods were calculated for agreement using the kappa
coefficient (κ). Ethical aspects This study is in accordance with the guidelines and rules for research involving
human subjects (resolution 196/1996 of the National Health Council) and was
approved by the research ethics committee of UNISUL, Opinion No.
11.190.04.01). All patients who agreed to participate in the study signed an informed consent
form in duplicate. Both the case histories and the photographs were performed on
a secrecy basis. 

All patients - - regardless of age, gender, socioeconomic status, skin type or
origin - who sought a BHU in Santa Catarina with visible dermatological
complaints and after initial medical assessment with a nonspecialist were
referred for consultation with a dermatologist (specialist) via telediagnosis
were admitted to this study. However, only those who signed the informed consent
form participated in the study. 

Cases: patients who presented with suspect lesions detected by the attending
primary care physician. Controls: patients who had lesions compatible with skin cancer according to the
specialist's assessment. Exclusion criteria were: patients who attended the consultation with
dermatological complaints, but had no visible lesions or who had lesions which
presented insufficient quality for evaluation or patients who were undergoing
dermatological treatment and presented only clinical symptoms without visible
dermatological symptoms. All those who did not sign the consent form were also
excluded from the study. 

Aiming at the standardization of procedures for the collection of data for this
study, which occurred by means of digital imaging, we provided trainings to the
professionals working at the nine healthcare centers which are evenly
distributed among the macro-regions that make up the State of Santa Catarina.
This space was called Qualified Healthcare Units for the Collection of Tests and
counted with the participation of professional technicians, previously trained
to obtaining adequate images. 

During on-site consultation with a non-specialist physician in the Basic
Healthcare Units, all relevant patient data were entered into an electronic
health record. This made a referral to a specialist possible, when needed.
Patients who had signs or symptoms that suggested skin cancer had indication of
referral. Those patients who were selected for a consultation with a dermatologist were
conducted to the nearest Qualified Healthcare Unit for the Collection of Tests,
where data collection was conducted once the consent form had been signed. The photographic record for the investigation of suspected cancer cases was
performed in three steps: Panoramic Photo, Close-up with scale and
Dermoscopy. Regarding the Panoramic Photo, the technician was instructed to identify each
lesion using a label with the date, patient's initials and lesion number. He
also was told to make a panoramic image of the region of the body affected by
one or more lesions (head, torso, arms and legs, either front or back). At this
stage, the technician was instructed not to use the zoom function. The second step consisted of close-up with scale. The technician was instructed
to take the picture at a distance of about thirty centimeters from the lesion,
without using the zoom function and to place a scale parallel to the lesion in
order to serve as a reference of the actual size of the lesion. Finally, the third photo was taken by using dermoscopy. The dermatoscope was
connected to the digital camera. In this step, the technician applied gel on the
lens of the camera and photographed each lesion by using the dermatoscope placed
against the patient's skin and the maximum zooming level. After collection, the data were transmitted through an environment developed
exclusively for sending data corresponding to each patient on the Internet.
Whenever a new case arrived, a message was sent to the participating physician
(specialist), communicating the new remote consultation request, which was
accessed through a restricted site. The doctor in charge would show his diagnosis autonomously, respecting the
seventy-two-hour deadline and using the clinical photographs and medical data
sent by the non-specialist physician. 

A protocol was used as an instrument for data collection. It included information
relating to the procedure used for obtaining images of the lesions and the
anatomical region affected. After the protocol was completed, the photos were
sent via the Internet to a restricted virtual site, to which the remote
specialist (dermatologist) and the on-site non-specialist physician had
access. The collection of images was performed by using Cyber Shot cameras, since
photographs of lesions are part of the basic data necessary for conducting
telediagnosis. These images were then uploaded onto the computer via USB cable
and stored in JPEG format. 

Data were analyzed using the SPSS 18.0 program. Sensitivity and specificity as
well as PPV and NPV, and accuracy of the diagnosis of each tumor type were
calculated. The odds that the medical expert could make a diagnosis for the
dermatological examination sent, following the established protocol or not, were
calculated by the odds ratio, considering the 95% confidence interval and
p<0.05. For validation, methods were calculated for agreement using the kappa
coefficient (κ). 

This study is in accordance with the guidelines and rules for research involving
human subjects (resolution 196/1996 of the National Health Council) and was
approved by the research ethics committee of UNISUL, Opinion No.
11.190.04.01). All patients who agreed to participate in the study signed an informed consent
form in duplicate. Both the case histories and the photographs were performed on
a secrecy basis. 

The analyzed group consisted of 333 requests for evaluation. Of these, 149 were
invalidated for various reasons, such as: trial examination; repeated examination,
examination not in accordance with the protocol and examination with image out of
focus, as shown in . With regard to examinations not in accordance with the protocol being a reason for
invalidation, one hundred twenty-eight such episodes were reported between the
months of January and July, accounting for 85.91% of the total number of
examinations. The incidence images out of focus caused the invalidation of twelve
cases - 8.05% of the total number of invalidated examinations. 149 cases received from the primary healthcare network were invalidated. This
occurred most frequently in January and accounted for fifty cases (33.55%) and least
frequently in July (3.35%). Likewise, the most prevalent reason for invalidation of
diagnostic hypotheses was due to examinations which were not performed in accordance
with the protocol and the least prevalent reason was due to trial examinations,
according to the data cited above. Regarding the remaining group - 184 evaluation requests - we found a higher frequency
of females (135 - 73.37%). The hegemonic skin color was white. Phototype III was
evidenced in 135 patients (55.97%). Phototype II in 30 patients (16.84%) and
phototype I in 19 patients (10.86%). The average age was 54.74 (± 15.17) years. Furthermore, we analyzed the compatibility of diagnoses for each type of skin
neoplasia, according to , itemized
below. Among the analyzed group, 71.74% were referred with suspected basal cell carcinoma
(BCC), 4.89% with suspected squamous cell carcinoma (SCC) and 23.37% with suspected
malignant melanoma (MM). Regarding BCC, 19.57% of the cases analyzed by teledermatology obtained this
neoplasia as a diagnostic hypothesis. Of these, 15.38% were diagnosed as other skin
cancers, while 21.21% confirmed the suspicion received from the primary healthcare
unit. On the other hand, of the 132 cases sent to telediagnosis as suspected BCC,
78.79% were not compatible with the diagnosis proposed by the specialist and of 52
referrals diagnosed as non-BCC carcinomas, 84.62% agreed with the dermatologist's
opinion. In the case of SCC, of all valid examinations, 7.07% were confirmed by the specialist
as such. 5.14% of these were derived from the primary healthcare system as other
skin cancers and 44.44% as suspected SCC. However, of 9 examinations coming as SCC,
55.56% were incompatible with the proposed diagnosis made by the telemedicine
physician. With regard to MM, only 2.17% were classified as such by the dermatologist. Of these,
0.71% were diagnosed as other skin cancers, while 6.98% confirmed the suspected
diagnosis of primary care. However, of the 43 suspected cases of MM, 93.02% showed
no compatibility. After checking the compatibility between suspicion and diagnostic hypothesis, we
analyzed the percentage of diagnostic examinations according to each type of skin
cancer, namely: sensitivity, specificity, accuracy, positive predictive value and
negative predictive value, as shown in . Sensitivity for the diagnosis of BCC was 77.77%. This means that, among the 36 cases
qualified by teledermatology as BCC, 28 were sent to telediagnosis with this
suspicion, whereas 8 cases were diagnosed by the specialist as BCC, although they
had been referred to as other skin cancers. Specificity in regard to the BCC was 29.73% Therefore, of the 148 cases so classified
by the specialist, only 44 were sent as being other skin cancers. 39.13% of accuracy was obtained in the diagnosis of BCC. Therefore, 28 suspected
cases of BCC were compatible with the teledermatology diagnosis, while 44 cases of
suspected other skin cancers (non-basal cell cancers) were also compatible. Both
accounted for a total of 184 tests performed. With regard to SCC, diagnostic sensitivity was 30.77%. Thus, among the 13 cases
classified as SCC by the specialist, 4 had been sent by primary care with such
suspecion, while 9 had been sent as other skin cancers, not SCC. SCC specificity was 97.07%. Therefore, of the 171 cases which did not have such a
diagnostic proposal, 166 were suspected to be other skin cancers The accuracy of SCC diagnosis was 92.39%. From a total of 184 examinations performed,
4 suspected SCC cases presented diagnostic compatibility, whereas 166 suspected
cases of other skin cancers (not SCC) were also compatible. Regarding MM, the diagnostic sensitivity was 75%. That is, among the 4 cases
classified as MM, 3 were sent to telediagnosis with such suspicion, while 1 was
described by the teledermatology physician as MM, although it had been classified as
other skin cancer by the non-specialist physician. MM specificity was 77.77%. Thus, of the 180 cases presented by telediagnosis as MM,
140 had been suspected as other skin cancers, not MM. The accuracy of the diagnosis of MM was 77.70%. Therefore, 3 suspected MM cases were
consistent with the specialist's opinion, while 140 examinations with suspecion of
other neoplasias were also compatible. A total of 184 examinations were
conducted. Regarding the PPV of BCC, we obtained a value of 21.21%. This means that, of the 132
examinations referred to the specialist as suspected BCC, 28 were compatible. The
negative predictive value of BCC was 84.62%. Of 52 examinations sent by the primary
care system as other skin cancers, 44 were classified as non-BCC by the
dermatologist. VPP of SCC was found to be 44.44%. Of the 9 examinations sent by primary care as
suspected SCC, 4 were consistent with the diagnosis made by the specialist. NPV of
CEC was 94.86%, since of 175 reports sent to telediagnosis as other skin neoplasias,
166 were not considered by the specialist as SCC. PPV of MM was found to be 6.97%. Of the 43 examinations referred to as malignant
melanoma, only 3 were consistent with the diagnosis proposed by the specialist. In
contrast, the NPV of MM was 99.29%. Of the 141 examinations referred to
telediagnosis as MM, 140 showed diagnostic compatibility. Regarding the use of the protocol for the standardization of digital imaging
obtention, this study found that, of the 333 requests generated in the primary
healthcare network, 180 examinations indicated that the protocol had been followed
appropriately, and among these, 159 were considered suitable to be sent to the
specialist for evaluation. Conversely, 153 requests indicated some problem in
compliance with the protocol. Of these, only 25 could be analyzed. The odds calculated for the dermatologist to make the teledermatology diagnosis
following the protocol correctly, was OR 38.77 (95% CI, 20.74 to 72.43; p
<0.001), showing a substantial agreement (κ = 0.69 ). 

This study was conducted in the search for alternatives to ensure proper access to
health care and in partnership with non-specialist doctors from different
macro-regions of Santa Catarina. Its aim was to analyze the compatibility index
between the suspected diagnosis of skin cancer made by basic care, and the diagnosis
proposed by teledermatology. Moreover, we aimed at validating a protocol for
standardizing the obtention of digital images for telediagnosis reports in
dermatology. Currently, CFM Resolution 1.643/2002 defines and regulates the provision of services
through telemedicine. Telediagnosis in Dermatology is not yet regulated in the
Unified Healthcare System (SUS). Santa Catarina is a pioneer in the use of
teledermatology. However, in order to guarantee the long-term sustainability of the
model, it has to be regulated by CONITEC (National Commission for Technology
Incorporation in the SUS), a body of the ANVISA (National Health Surveillance
Agency). This is a unique study that seeks to assist in the improvement of the teledermatology
system in the State of Santa Catarina. Methodological efforts to legitimize the
results were undertaken. First, the sampling census design used in this study assured a valid number of
participants to be included in the investigation. Second, the quality of data
collection was assured by the standardization of procedures, which was achieved
through the provision of trainings to the professionals of healthcare centers in the
state who were performing the tests, and through the technology employed - an
environment exclusively created on the Internet for sending patients' data. Third,
the use of protocols as an instrument for objective data collection, together with
predefined procedures for the performance of photographs of skin lesions, avoids
vulnerabilities as interpretation biases, confirming the verification of adequate
diagnosis. Fourth, the careful application of the methodology generated 149
invalidations, leaving only 184 requests to be analyzed. Finally, the fact that the research was conducted at the Center for Telemedicine and
Telehealth of the State Secretariat of Health was one of the strengths of conducting
this study, since the above-mentioned environment is a reference environment in
terms of telemedicine in Santa Catarina. In contrast, the recent implementation of teledermatology care in the state, parallel
to the fact that we depend on a virtual environment software, caused practical
problems to the system. In addtion, we had to deal with the inexperience of the
technical teams (even after training was provided), and with difficulties in the
operation of the virtual program, which resulted in a significant reduction in the
total number of requests sent to telediagnostics. Regarding the number of invalidations, we found that the highest rates occurred in
the first months. This result may be associated with the fact that the system had
been recently implemented, since invalidations gradually reduced in the subsequent
months, indicating the adaptation of the team and their learning of the technique.
Moreover, it could mean that these figures will decrease even more with time.
Corroborating the hypothesis, it is noteworthy that the main reason for invalidation
was due to sending examinations which were not conducted in accordance with the
protocol, i.e., examinations whose annulment occurred due to incorrect use of
photography techniques and/or data completion. The invalidation rate later possibly
reduced because the team acquired more experience with the procedures. Conversely, although in the early phase of implementation of the system, the month of
February showed low rates of invalidations. This can be explained by the lower
amount of requests analyzed by the specialist physician in these period. In the case of the remaining group, the majority of subjects were female. This result
may be linked to a higher demand for primary care services by this population. Such
supposition is supported by Figueiredo and Pinheiro et al, who argue that women are
more concerned with their personal health. , Another
possibility may be related to the higher incidence of skin cancer in the female
population, since, according to Azulay et al, BCC - which accounts for 70% of cases
- and MM are slightly more frequent in women. Most of the cases studied were white persons (83.67%), including phototypes I, II and
III, a factor that most likely is related to the higher incidence of skin cancer in
people with lighter skin color. This hypothesis is based on the literature, which
supports the direct relationship between skin cancer and skin color, in the sense
that the lighter the skin color, the greater the frequency of occurrence of skin
cancer. - Nevertheless, another plausible explanation
for the high incidence of white people in the study is due to the fact that the
population of Santa Catarina is predominantly light-skinned (84%), according to
IBGE. As to the age group, the average age of subjects was 54.9 years, which corroborates
the data found by other authors, like Ignatius et al and Nasser. , This can be explained by the cumulative action of ultraviolet
radiation on the skin over the years, a significant risk factor for the development
of skin cancer, according to the authors mentioned before. Turning to the diagnostic suspicions sent by the primary care network, we found that
most referrals (71.74%) were suspicions of BCC. One possible explanation for this is
the high prevalence of this type of cancer in the population, as studies by Azulay
et al, Chinem & Miot and the National Cancer Institute (INCA) report. These
studies state that BCC corresponds to 70% of all skin neoplasias. , , Moreover, the
fact that this type of cancer is considered the most frequent in the literature may
lead non-specialists to generalize suspected cases in the case of diagnostic doubt,
also increasing the number of referrals due to BCC. With respect to the SCC, the total number of referrals, compared to BCC and MM, was
significantly lower (4.89%), which confirms the epidemiology found in the
literature, according to studies by Azulay et al., Nasser and Nunes et al. , , This can be
explained by the difficulty faced by the non-specialist physician in distinguishing
between BCC and SCC, as they are considered as one another's main differential
diagnoses, according to Azulay et al. Moreover, as already said before, when uncertain about the diagnosis, the general
practitioner may have opted for the one known to be more common, which possibly
reduced the incidence of suspected SCC. Likewise, the fact that the incidence of
suspected MM in this study does not agree with the literature, may result in
significant reduction of referrals due to SCC, since the INCA and Dimatos et al , state that the frequency of melanoma accounts for around 4%, while in
the present study 23.37% of the reports were sent as suspected MM. Thus, with respect to MM, as already discussed above, the number of referrals was
incongruent with the current literature. , This possibly
occurred due to the difficulty of the non-specialist physician in distinguishing
between malignant lesions and lesions with benign features, given that MM is a tumor
originating from melanocytes which develops, in most cases, from a preexisting
nevus, i.e., possibly even before a nevus with changes that do not characterize
malignancy, the general practitioner classifies it as MM. However, sensitivity was found to be 75%, which is a
reasonable value. This information deserves further reflection, though, since it
should be taken into account that the high number of referrals as suspected MM, in
association with the low prevalence of the disease, increases the ods of diagnostic
compatibility. Likewise, MM specificity may be related to this hypothesis, since in
40 cases of suspected MM, no compatibility was observed. With regard to diagnostic tests applied to BCC, the sensitivity found denotes that
generalist physicians were able to identify most of the cases thus diagnosed by the
specialist. This means that the general practitioner would be able to identify this
neoplasia in patients. However, this data cannot be interpreted in isolation, given
that, in terms of specificity, the value found was very low, suggesting that these
professionals do not demonstrate the ability to exclude the possibility of BCC when
the patient does not have this condition. According to the specialist, this possibly
occurred because the generalist is able to make referrals when faced with a
suspicious lesion, but fails to recognize the condition. Regarding the accuracy for BCC, the present study demonstrated that the level of
compatibility between the specialist and the non-specialist physicians was low. It
is important to highlight that in 104 cases for which the medical expert dismissed
the diagnosis of BCC, the non-specialist physician did not disregard the condition,
but, on the contrary, he suggested its existence. This fact proves to be extremely
important, since this is a condition whose diagnosis is a determining factor in the
treatment and cure of the patient. With respect to the sensitivity found for SCC, we observed a greater difficulty of
general practitioners in identifying this disease. Such an event may be related to
the lack of specific knowledge in for distinguishing among skin neoplasias. This
leads non-specialists, in case of diagnostic doubt, to opt for the more frequent
neoplasia that belongs to their differential diagnosis, such as BCC. However,
specificity values for SCC were very high, perhaps because of a lack of knowledge
about the disease, which provides the non-specialist physician with a greater
possibility of diagnostic exclusion than inclusion. However, this information
deserves some notes, because although the specificity of SCC was found to be quite
high, it is relevant to mention that we found a low absolute number of requests
generated as suspected SCC. This does not correlate with the studied literature -
which expects a prevalence of around 20%. This may give rise to increased cases of
BCC and/or MM, and thus increase the supposed correctness of the non-specialist
physician with regard to non-SCC cases, resulting in a high specificity. , , Moreover, with respect to SCC, the accuracy score obtained can be considered high,
and the highest among the types of cancer studied. This is possibly due to the high
level of specificity founf for SCC, whose probable cause has already been
analyzed. Regarding the use of the protocol as a method for collecting digital images, we found
that, when correct, 88.33% of the referrals were considered valid and could thus be
evaluated by a specialist. Likewise, the absence of appropriate protocol generated
only 16.34% of analyzable requests. In addition, we highlight the possibility of some of the tests being considered
suitable for diagnosis by specialists (although they had not correctly followed the
protocol) due to the low complexity and/or typical presentation of the lesion, which
is in accordance to the literature. Thus,
when faced with high complexity lesions or lesions without typical features, the use
of a structured standard protocol is even more relevant, in order to provide the
remote physician with the most efficient tools for making the diagnosis. These facts, associated with the Odds ratio values found - which showed that the odds
of obtaining a diagnosis from a specialist was 38.77 times higher among valid tests,
when compared to all invalid tests - suggest that the use of the protocol for
obtaining images for telediagnosis may be able to increase the number of tests that
the dermatologist can offer, since, according to the literature, the technical
quality of the photos is a determining factor in the level of diagnostic accuracy
and interobserver agreement. , , This is because the protocol includes: a
panoramic photo, which shows the lesion and the affected anatomical region without
using the zoom function, enabling the comparison of the lesion size with the
patient's body size; a close-up photo with a scale, which allows a close to ideal
viewing of the lesion, similar to the face-to-face dermatological examination,
besides enabling the verification of the actual size of the lesion; and dermoscopy,
which provides key data for the diagnosis of melanocytic lesions (melanoma and
benign melanocytic lesions), as well as an approximate analysis of structures
present in non-melanoma skin cancers. These steps contribute to ensure the technical
quality of the photo, making it suitable for evaluation. Moreover, the fact that the correlation between the on-side diagnosis and the
diagnosis made by teledermatology, when obtained by dermatologists, varies between
80.5 and 91.6%. , However, in these studies, the images were
not obtained through a structured protocol and yet the agreement found was high.
This way, it is understood that the use of a standard protocol such as the one used
in this study may further improve the compatibility of telediagnosis, either among
experts or not, thus consolidating teledermatology as a skilled method for
diagnosing skin lesions. A limitation of the study was that the analysis of all images was performed by a
single specialist. However, the diagnostic accuracy of dermatologists was not being
evaluated, but rather the possibility of a lesion being or not compatible with skin
cancer. Thus, sensitivity is more important than specificity in the analysis of
images. Thus all doubtful images were considered compatible. Due to the problems found during the conduction of this study, which resulted in
several invalidations, this research gave rise to changes in the collection and
submission of test requests, thus contributing to the improvement of teledermatology
in Santa Catarina. For all that, this research demonstrates the importance of using teledermatology as a
modern tool of access to health, since it is a diagnostic method that enables early
detection of skin cancer, thus decreasing the number of unnecessary referrals to a
dermatologist. Therefore, it helps not only to reduce the waiting time for
face-to-face consultations, but also the costs associated with this process. In addition, the implementation of the teledermatology system in Santa Catarina
deserves to be expanded within the context of public policies to provide health
access, because it has shown to be a feasible way to address the lack of medical
specialists in the public healthcare network, especially in more remote locations.
It can be used not only as dermatological care, but also as a method of health
planning, research, education and clinical discussion. 

The application of a structured protocol was found to be statistically significant,
increasing by 38.77 times the odds that examinations were considered suitable for
evaluation by the specialist, when correctly completed. 

