Impact of 
Data Collection Between June 2017 and February 2022, 449 patients with various cancers were referred for 68 Ga-FAPI PET/CT imaging. All patients underwent conventional gold standard imaging (GSI). 68 Ga-FAPI PET was also performed to address issues such as inconclusive findings on other imaging modalities or to assist in radiotherapy planning. Of the 449 patients initially referred, 226 were selected for this retrospective analysis on the basis of the following inclusion criteria: an age of 18 y or older, adequate GSI data available, no secondary malignancy within 5 y, and an interval of less than 100 d between GSI and 68 Ga-FAPI PET, with no intervening therapy and no evidence of progression between GSI and 68 Ga-FAPI PET . The local institutional review board approved this retrospective analysis (study S-430/2022). A subgroup of patients analyzed here were included in previous projects with small and midsize patient cohorts, in which we evaluated the impact of 68 Ga-FAPI PET/CT on the staging and clinical management of pancreatic ductal adenocarcinomas  and adenoid cystic carcinomas  but not the impact on staging or clinical management of 68 Ga-FAPI PET/CT for various cancer diseases . 68 Ga-FAPI PET/CT Imaging Four tracer variants of 68 Ga-FAPI were used in this study: 68 Ga-FAPI-02 (21 patients), 68 Ga-FAPI-04 (63 patients), 68 Ga-FAPI-46 (101 patients), and 68 Ga-FAPI-74 (41 patients). All tracers were synthesized and labeled as previously described . A Siemens Biograph mCT Flow scanner was used for PET imaging, according to previously published protocols . Briefly, a low-dose CT scan with or without contrast medium was first obtained, followed by a 3-dimensional PET acquisition (matrix, 200 × 200). After image reconstruction, emission data were corrected for attenuation, scatter, and decay. All PET scans were acquired 60 min after administration of 200 ± 50 MBq of 68 Ga-labeled FAPI tracers. TNM Staging Based on 68 Ga-FAPI PET Compared with GSI Staging guidelines were based on the eighth edition of the TNM classification of malignant tumors of the Union for International Cancer Control based on GSI and 68 Ga-FAPI PET/CT findings by 1 board-certified radiologist, 1 board-certified radiation oncologist, and 2 board-certified nuclear medicine physicians in consensus. Staging was based on reviewing clinical imaging records, but if the written record was inadequate, images were reviewed by three of the authors. lists GSI modalities according to the types of cancer. Changes in TNM stage, numeric changes, and the location of metastases were recorded. Staging changes comparing 68 Ga-FAPI PET with GSI were considered major according to the following criteria: T, any change in T stage or evidence of invasion of other organs by the primary tumor; N, a change from N0 to N+ or vice versa; and M, a change from M0 to M+ or detection of new metastases in other organs or vice versa. Minor staging changes were classified according to the following criteria: N, detection of additional lymph node metastases in N+-positive patients if not affecting N stage; and M, detection of additional distant metastases in the same organ or vice versa. Sankey plots for were produced using the freeware tool SankeyMATIC ( www.sankeymatic.com ). Evaluation of Impact of 68 Ga-FAPI PET on Oncologic Management Changes in clinical management related to additional findings on 68 Ga-FAPI PET were recorded after retrospective review of patient charts by three of the authors. Changes in oncologic management (management based on 68 Ga-FAPI PET/CT vs. management based on GSI) were classified as follows: fundamental alterations in the type or intent of treatment type were classified as major, whereas changes within an already prescribed treatment regime were classified as minor. Statistical Analysis Data were analyzed descriptively by comparing numeric results and percentages of TNM changes and changes in oncologic management. 

Between June 2017 and February 2022, 449 patients with various cancers were referred for 68 Ga-FAPI PET/CT imaging. All patients underwent conventional gold standard imaging (GSI). 68 Ga-FAPI PET was also performed to address issues such as inconclusive findings on other imaging modalities or to assist in radiotherapy planning. Of the 449 patients initially referred, 226 were selected for this retrospective analysis on the basis of the following inclusion criteria: an age of 18 y or older, adequate GSI data available, no secondary malignancy within 5 y, and an interval of less than 100 d between GSI and 68 Ga-FAPI PET, with no intervening therapy and no evidence of progression between GSI and 68 Ga-FAPI PET . The local institutional review board approved this retrospective analysis (study S-430/2022). A subgroup of patients analyzed here were included in previous projects with small and midsize patient cohorts, in which we evaluated the impact of 68 Ga-FAPI PET/CT on the staging and clinical management of pancreatic ductal adenocarcinomas  and adenoid cystic carcinomas  but not the impact on staging or clinical management of 68 Ga-FAPI PET/CT for various cancer diseases . 

Ga-FAPI PET/CT Imaging Four tracer variants of 68 Ga-FAPI were used in this study: 68 Ga-FAPI-02 (21 patients), 68 Ga-FAPI-04 (63 patients), 68 Ga-FAPI-46 (101 patients), and 68 Ga-FAPI-74 (41 patients). All tracers were synthesized and labeled as previously described . A Siemens Biograph mCT Flow scanner was used for PET imaging, according to previously published protocols . Briefly, a low-dose CT scan with or without contrast medium was first obtained, followed by a 3-dimensional PET acquisition (matrix, 200 × 200). After image reconstruction, emission data were corrected for attenuation, scatter, and decay. All PET scans were acquired 60 min after administration of 200 ± 50 MBq of 68 Ga-labeled FAPI tracers. 

68 Ga-FAPI PET Compared with GSI Staging guidelines were based on the eighth edition of the TNM classification of malignant tumors of the Union for International Cancer Control based on GSI and 68 Ga-FAPI PET/CT findings by 1 board-certified radiologist, 1 board-certified radiation oncologist, and 2 board-certified nuclear medicine physicians in consensus. Staging was based on reviewing clinical imaging records, but if the written record was inadequate, images were reviewed by three of the authors. lists GSI modalities according to the types of cancer. Changes in TNM stage, numeric changes, and the location of metastases were recorded. Staging changes comparing 68 Ga-FAPI PET with GSI were considered major according to the following criteria: T, any change in T stage or evidence of invasion of other organs by the primary tumor; N, a change from N0 to N+ or vice versa; and M, a change from M0 to M+ or detection of new metastases in other organs or vice versa. Minor staging changes were classified according to the following criteria: N, detection of additional lymph node metastases in N+-positive patients if not affecting N stage; and M, detection of additional distant metastases in the same organ or vice versa. Sankey plots for were produced using the freeware tool SankeyMATIC ( www.sankeymatic.com ). 

68 Ga-FAPI PET on Oncologic Management Changes in clinical management related to additional findings on 68 Ga-FAPI PET were recorded after retrospective review of patient charts by three of the authors. Changes in oncologic management (management based on 68 Ga-FAPI PET/CT vs. management based on GSI) were classified as follows: fundamental alterations in the type or intent of treatment type were classified as major, whereas changes within an already prescribed treatment regime were classified as minor. 

Data were analyzed descriptively by comparing numeric results and percentages of TNM changes and changes in oncologic management. 

Patient Characteristics Our cohort consisted of 137 male and 89 female patients with a mean age of 62 y (range, 20–86 y). In 48 patients imaging was performed at initial diagnosis, whereas in 50 patients imaging was performed for assessing metastatic disease. In 34 patients imaging was obtained for progressive disease, in 77 patients it was obtained for follow-up, and in 14 patients it was obtained in the adjuvant setting after surgery. In 3 cases the clinical situation could not be determined. The most common tumor site was pancreatic cancer (77 patients), head and neck tumors (29 patients), and lung cancer (23 patients). The cohort also included some rare tumors such as uterine sarcoma, appendiceal carcinoma, and thymus cancer. Oncologic diagnoses and clinical characteristics are listed by tumor type in Supplemental Table 1 (supplemental materials are available at http://jnm.snmjournals.org ). Impact of 68 Ga-FAPI PET on TNM Staging Among 205 patients, 86 (42%) experienced a TNM change after 68 Ga-FAPI PET/CT. For most (91%) of these cases, a major change was observed, and upstaging (53 major, 6 minor) was more frequent than downstaging (29 major, 2 minor). The most frequent reason for upstaging was the detection of new metastases on 68 Ga-FAPI PET/CT compared with GSI. Three patients with carcinoma of the gallbladder  and lung cancer  had both major upstaging and major downstaging after 68 Ga-FAPI PET/CT. In addition, 1 patient with lung cancer showed major downstaging and minor upstaging. Major changes occurred most frequently for pancreatic cancer patients (26 upstaged, 6 downstaged) and lung cancer (5 upstaged, 9 downstaged). provides an overview of changes in TNM staging for all patients, and Supplemental Table 5 provides changes in TNM staging of rare entities. depicts changes in N and M staging of the 3 most common entities—pancreatic cancer, head and neck tumors, and lung cancer—in Sankey plots. Supplemental Tables 2–4 provide an overview of the locations of the additional findings on 68 Ga-FAPI PET/CT compared with GSI, as well as 68 Ga-FAPI–negative lesions, which led to staging changes in these 3 entities. For 21 patients with glioma, there were no TNM staging guidelines. Impact of 68 Ga-FAPI PET on Patient Management Among the 226 patients who underwent 68 Ga-FAPI PET/CT for staging or restaging, 18 had no further clinical information available. Of the remaining 208 patients, 117 (56.3%) had a change in clinical management; however, major changes in management occurred in only 14 patients (12%). The major changes in management after 68 Ga-FAPI PET/CT included irradiation of a new organ, 68 Ga-FAPI radioligand therapy, chemotherapy in place of radiation therapy, additional treatments such as surgery or chemotherapy, or a change in treatment intent (curative vs. palliative). Major treatment changes due to 68 Ga-FAPI PET/CT more frequently led to systemic therapy in place of local treatment (4 cases) or local treatment in place of systemic treatment (1 case). Among the minor changes caused by findings on 68 Ga-FAPI PET/CT, the most frequent was adjustment of the target volume for patients undergoing radiation therapy. Clinical management changed most frequently for pancreatic cancer (7 major, 23 minor), lung cancer (1 major, 13 minor), and head and neck tumors (1 major, 24 minor). shows the changes in oncologic management for all cancer types, and Supplemental Table 6 shows changes in oncologic management for each of the rare entities. Differences Between Clinical Settings To evaluate the potential influence of disease state on the impact of 68 Ga-FAPI PET/CT, we divided our cohort into 3 subgroups: primary staging ( n = 48), follow-up or adjuvant therapy ( n = 91), and progressive disease or recurrence ( n = 84). Three patients for whom the clinical setting remained unclear were excluded . 68 Ga-FAPI PET/CT led to changes in TNM staging less frequently in the primary and follow-up settings than in the progressive disease/recurrence setting. However, the impact on oncologic management was highest in the primary setting, followed by progressive disease/recurrence and finally follow-up, mostly because of 68 Ga-FAPI PET/CT–related changes in radiotherapy planning . Case Vignettes Case 1 A 64-y-old woman with pancreatic ductal adenocarcinoma achieved a complete remission after resection of the tail of the pancreas, with splenectomy, lymphadenectomy, and adjuvant chemotherapy (FOLFIRINOX [fluorouracil, leucovorin, irinotecan, and oxaliplatin] and oxaliplatin) and resection of the paraaortic lymph nodes and pulmonary metastases . The tumor marker CA 19.9 had increased from 960 to 1,600 ng/mL, but restaging with contrast-enhanced CT did not reveal any sites of recurrence. A 68 Ga-FAPI PET/CT scan revealed pulmonary metastases with mediastinal and paraaortic lymph node metastases. Retrospectively, we observed faint radiologic correlates for these metastases on previous CT scans, which were not prospectively interpreted as positive. Thus, 68 Ga-FAPI PET/CT restaged the patient from cT0cN0cM0 to cTxcN1cM1, leading to a major change in oncologic management. Previously, the patient was being observed, but after the 68 Ga-FAPI PET/CT scan, systemic chemotherapy (FOLFIRINOX followed by 5-fluorouracil) was administered and resulted in regression of the pulmonary and lymphatic tumor lesions. Case 2 A 78-y-old man presented with primary non–small cell lung cancer. GSI with 18 F-FDG PET/CT showed extensive mediastinal involvement, with cervical lymph node and adrenal metastases . 68 Ga-FAPI PET/CT confirmed the primary and cervical lymph node disease, but the adrenal mass did not demonstrate uptake and was therefore reassessed as more likely benign. Before the 68 Ga-FAPI PET/CT, the patient was to undergo selective irradiation of the left adrenal gland, but this was cancelled after the scan. The patient underwent definitive irradiation of the mediastinum and cervical lymph nodes. 

Our cohort consisted of 137 male and 89 female patients with a mean age of 62 y (range, 20–86 y). In 48 patients imaging was performed at initial diagnosis, whereas in 50 patients imaging was performed for assessing metastatic disease. In 34 patients imaging was obtained for progressive disease, in 77 patients it was obtained for follow-up, and in 14 patients it was obtained in the adjuvant setting after surgery. In 3 cases the clinical situation could not be determined. The most common tumor site was pancreatic cancer (77 patients), head and neck tumors (29 patients), and lung cancer (23 patients). The cohort also included some rare tumors such as uterine sarcoma, appendiceal carcinoma, and thymus cancer. Oncologic diagnoses and clinical characteristics are listed by tumor type in Supplemental Table 1 (supplemental materials are available at http://jnm.snmjournals.org ). 

68 Ga-FAPI PET on TNM Staging Among 205 patients, 86 (42%) experienced a TNM change after 68 Ga-FAPI PET/CT. For most (91%) of these cases, a major change was observed, and upstaging (53 major, 6 minor) was more frequent than downstaging (29 major, 2 minor). The most frequent reason for upstaging was the detection of new metastases on 68 Ga-FAPI PET/CT compared with GSI. Three patients with carcinoma of the gallbladder  and lung cancer  had both major upstaging and major downstaging after 68 Ga-FAPI PET/CT. In addition, 1 patient with lung cancer showed major downstaging and minor upstaging. Major changes occurred most frequently for pancreatic cancer patients (26 upstaged, 6 downstaged) and lung cancer (5 upstaged, 9 downstaged). provides an overview of changes in TNM staging for all patients, and Supplemental Table 5 provides changes in TNM staging of rare entities. depicts changes in N and M staging of the 3 most common entities—pancreatic cancer, head and neck tumors, and lung cancer—in Sankey plots. Supplemental Tables 2–4 provide an overview of the locations of the additional findings on 68 Ga-FAPI PET/CT compared with GSI, as well as 68 Ga-FAPI–negative lesions, which led to staging changes in these 3 entities. For 21 patients with glioma, there were no TNM staging guidelines. 

68 Ga-FAPI PET on Patient Management Among the 226 patients who underwent 68 Ga-FAPI PET/CT for staging or restaging, 18 had no further clinical information available. Of the remaining 208 patients, 117 (56.3%) had a change in clinical management; however, major changes in management occurred in only 14 patients (12%). The major changes in management after 68 Ga-FAPI PET/CT included irradiation of a new organ, 68 Ga-FAPI radioligand therapy, chemotherapy in place of radiation therapy, additional treatments such as surgery or chemotherapy, or a change in treatment intent (curative vs. palliative). Major treatment changes due to 68 Ga-FAPI PET/CT more frequently led to systemic therapy in place of local treatment (4 cases) or local treatment in place of systemic treatment (1 case). Among the minor changes caused by findings on 68 Ga-FAPI PET/CT, the most frequent was adjustment of the target volume for patients undergoing radiation therapy. Clinical management changed most frequently for pancreatic cancer (7 major, 23 minor), lung cancer (1 major, 13 minor), and head and neck tumors (1 major, 24 minor). shows the changes in oncologic management for all cancer types, and Supplemental Table 6 shows changes in oncologic management for each of the rare entities. 

To evaluate the potential influence of disease state on the impact of 68 Ga-FAPI PET/CT, we divided our cohort into 3 subgroups: primary staging ( n = 48), follow-up or adjuvant therapy ( n = 91), and progressive disease or recurrence ( n = 84). Three patients for whom the clinical setting remained unclear were excluded . 68 Ga-FAPI PET/CT led to changes in TNM staging less frequently in the primary and follow-up settings than in the progressive disease/recurrence setting. However, the impact on oncologic management was highest in the primary setting, followed by progressive disease/recurrence and finally follow-up, mostly because of 68 Ga-FAPI PET/CT–related changes in radiotherapy planning . 

Case 1 A 64-y-old woman with pancreatic ductal adenocarcinoma achieved a complete remission after resection of the tail of the pancreas, with splenectomy, lymphadenectomy, and adjuvant chemotherapy (FOLFIRINOX [fluorouracil, leucovorin, irinotecan, and oxaliplatin] and oxaliplatin) and resection of the paraaortic lymph nodes and pulmonary metastases . The tumor marker CA 19.9 had increased from 960 to 1,600 ng/mL, but restaging with contrast-enhanced CT did not reveal any sites of recurrence. A 68 Ga-FAPI PET/CT scan revealed pulmonary metastases with mediastinal and paraaortic lymph node metastases. Retrospectively, we observed faint radiologic correlates for these metastases on previous CT scans, which were not prospectively interpreted as positive. Thus, 68 Ga-FAPI PET/CT restaged the patient from cT0cN0cM0 to cTxcN1cM1, leading to a major change in oncologic management. Previously, the patient was being observed, but after the 68 Ga-FAPI PET/CT scan, systemic chemotherapy (FOLFIRINOX followed by 5-fluorouracil) was administered and resulted in regression of the pulmonary and lymphatic tumor lesions. Case 2 A 78-y-old man presented with primary non–small cell lung cancer. GSI with 18 F-FDG PET/CT showed extensive mediastinal involvement, with cervical lymph node and adrenal metastases . 68 Ga-FAPI PET/CT confirmed the primary and cervical lymph node disease, but the adrenal mass did not demonstrate uptake and was therefore reassessed as more likely benign. Before the 68 Ga-FAPI PET/CT, the patient was to undergo selective irradiation of the left adrenal gland, but this was cancelled after the scan. The patient underwent definitive irradiation of the mediastinum and cervical lymph nodes. 

A 64-y-old woman with pancreatic ductal adenocarcinoma achieved a complete remission after resection of the tail of the pancreas, with splenectomy, lymphadenectomy, and adjuvant chemotherapy (FOLFIRINOX [fluorouracil, leucovorin, irinotecan, and oxaliplatin] and oxaliplatin) and resection of the paraaortic lymph nodes and pulmonary metastases . The tumor marker CA 19.9 had increased from 960 to 1,600 ng/mL, but restaging with contrast-enhanced CT did not reveal any sites of recurrence. A 68 Ga-FAPI PET/CT scan revealed pulmonary metastases with mediastinal and paraaortic lymph node metastases. Retrospectively, we observed faint radiologic correlates for these metastases on previous CT scans, which were not prospectively interpreted as positive. Thus, 68 Ga-FAPI PET/CT restaged the patient from cT0cN0cM0 to cTxcN1cM1, leading to a major change in oncologic management. Previously, the patient was being observed, but after the 68 Ga-FAPI PET/CT scan, systemic chemotherapy (FOLFIRINOX followed by 5-fluorouracil) was administered and resulted in regression of the pulmonary and lymphatic tumor lesions. 

A 78-y-old man presented with primary non–small cell lung cancer. GSI with 18 F-FDG PET/CT showed extensive mediastinal involvement, with cervical lymph node and adrenal metastases . 68 Ga-FAPI PET/CT confirmed the primary and cervical lymph node disease, but the adrenal mass did not demonstrate uptake and was therefore reassessed as more likely benign. Before the 68 Ga-FAPI PET/CT, the patient was to undergo selective irradiation of the left adrenal gland, but this was cancelled after the scan. The patient underwent definitive irradiation of the mediastinum and cervical lymph nodes. 

Although the sensitivity for detecting cancers with 68 Ga-FAPI PET/CT has been well reported, to date there is little information on the clinical impact of 68 Ga-FAPI PET/CT on oncologic patients. Our large-cohort–based results substantiate smaller studies, in which the impact of 68 Ga-FAPI PET on the staging and management of pancreatic ductal adenocarcinoma and on the staging of adenoid cystic carcinoma was reported . In the current analysis, we observed that 68 Ga-FAPI PET/CT resulted in changes in TNM staging in about 40% of patients. The impact on TNM staging was particularly pronounced in clinical settings of progressive disease and recurrence, which is in line with our previous findings in pancreatic ductal adenocarcinoma staging . In this diverse group of cancers, 68 Ga-FAPI PET/CT had the largest impact on pancreatic and lung cancer. Although 18 F-FDG PET/CT is clinically well established in lung cancer, 68 Ga-FAPI PET/CT appeared to surpass 18 F-FDG PET/CT in detecting additional disease, thus altering TNM staging. For instance, whereas 18 F-FDG PET/CT altered staging in 35% of patients with non–small cell lung cancer, compared with CT, in this study 68 Ga-FAPI PET/CT altered staging in 56% of such patients. . Similar results were observed for 18 F-FDG PET/CT for gastric adenocarcinoma, hepatic carcinoma, and pancreatic cancer . The PET-PANC trial demonstrated that 18 F-FDG PET/CT correctly changed the staging of pancreatic cancer in only 56 of 550 patients. However, 18 F-FDG PET/CT influenced management in 250 (45%) patients and stopped resection in 58 (20%) patients who were due to have surgery . In the current study, only a small percentage of patients had prior PET imaging ( 18 F-FDG, 68 Ga-DOTATOC, 68 Ga-PSMA) as part of their standard workup, and therefore, no comparison between 68 Ga-FAPI and other PET tracers can be made. However, a structured head-to-head comparison of staging based on 68 Ga-FAPI PET/CT and 18 F-FDG PET/CT would be great interest, since the latter modality is so frequently performed as a standard of care. The findings on 68 Ga-FAPI PET/CT influencing TNM staging also had a direct impact on clinical management. More than half our cohort had a change in management due to findings on 68 Ga-FAPI PET/CT that differed from GSI. A similar change of 30%–62% in patient management was seen after the introduction of PSMA PET/CT in prostate cancer, thus demonstrating the power of targeted PET agents to alter patient care . Interestingly, the greatest impact was on radiation therapy planning—for both PSMA PET/CT and 68 Ga-FAPI PET/CT—which underscores the additional value of PET imaging for radiotherapy planning. In our cohort, PET imaging was able to enhance target volume delineation, leading to reduced exposure of organs at risk and improved definition of the target volume. This finding is in line with findings from a large PET trial for patients with non–small cell lung cancer undergoing chemoradiation. Nestle et al. concluded that 18 F-FDG PET–based planning was able to improve local control at no cost of added toxicity . Similarly, 68 Ga-FAPI PET/CT also decreases off-target exposure and improves the target volume delineation, resulting in improved dosimetry for radiotherapy. As a side note, 68 Ga-FAPI PET/CT appears to be superior to other modalities in detecting peritoneal carcinosis, which is often difficult to detect on imaging. Several prior studies have suggested that 68 Ga-FAPI PET/CT has a higher sensitivity and specificity in the detection of peritoneal lesions in ovarian and colorectal cancer . Our data suggest that 68 Ga-FAPI PET/CT is an extremely promising diagnostic approach for peritoneal disease and is more sensitive and specific than contrast-enhanced CT and contrast-enhanced MRI. This study had several limitations. First, this retrospective trial was conducted at a single institution; however, the large size of the study counters, to some extent, potential patient selection biases. Most of the findings on 68 Ga-FAPI PET/CT were not histologically verified, although false positives can occur. There was also no evidence that the prescribed changes in patient management resulted in improved patient outcomes. Instead of 1 unified type of 68 Ga-FAPI PET/CT, 4 chemical variants were used, creating additional variables. However, most of the agents tested here appear to perform similarly, reducing the impact of this factor. Because the exclusion criteria allowed for a relatively long interval between GSI and 68 Ga-FAPI PET/CT (<100 d), we cannot fully exclude the possibility that in some patients the differences in TNM staging might have been due to actual disease progression. Thus, the results of this study must be considered preliminary. Despite these limitations, these results provide a basis for prospective randomized trials that can provide level 1 evidence of the value of 68 Ga-FAPI PET/CT. 

This study demonstrated that 68 Ga-FAPI PET/CT impacts both TNM staging and oncologic management in a high percentage of cancer patients with a variety of cancer types. 68 Ga-FAPI PET/CT detected numerous malignant lesions (in particular lung cancer, pancreatic cancer, and head and neck cancers) not visible on standard imaging and helped radiation therapy planning achieve superior target delineation. This innovative technology offers the potential to improve outcomes for patients by better defining the full extent of their disease. 

Stefan Koerber reports research grants from Viewray Inc. and honoraria from IBA Dosimetry and Think Wired! (outside the submitted work). Frederik Giesel is an advisor at ABX, Telix, SOFIE Biosciences, and α-Fusion and holds shares in the consultancy group iTheranostic. Jakob Liermann is funded by the Physician-Scientist Program of Heidelberg University, Faculty of Medicine. Thomas Walle reports stock ownership for Roche, Bayer, and Innate Pharma and research funding (outside the submitted work) from CanVirex AG, Basel, Switzerland, and the Institute of Clinical Cancer Research IKF GmbH, Frankfurt, Germany. Dirk Jaeger reports consulting fees from CureVac AG, Definiens, F. Hoffmann-La Roche Ltd., Genmab A-S, Life Science Inkubator GmbH, VAXIMM AG, OncoOne Research & Development Research GmbH, Oncolytics Biotech Inc., Zelluna, HDIT GmbH, AYOXXA, Seattle Genetics, BreakBio Corp., and Roche Pharma AG; received honoraria from SKK Kliniken Heilbronn GmbH, Georg Thieme Verlag, Terrapinn, Touch Medical Media, BMS GmbH & Co. KGaA, MSD, Guppe 5 Filmproduktion GmbH, AstraZeneca GmbH, the Department of Radiation Medicine at the University of Kentucky, the Norwegian Cancer Society Oslo, Wilhlem-Sander Stiftung, Else-Kröner-Fesenius Stiftung, Schering Stiftung, and NordForsk; and received support for attending meetings or travel from Amgen Inc., Oryx GmbH, Roche Glycart AG, Parexel.com , IKTZ HD GmbH, and BMS. Juergen Debus received grants from Accuray International Sàrl, Merck Serono GmbH, CRI–the Clinical Research Institute GmbH, View Ray Inc., Accuray Inc., RaySearch Laboratories AB, Vision RT Limited, Astellas Pharma GmbH, Astra Zeneca GmbH, Solution Akademie GmbH, Ergomed PLC Surrey Research Park, Siemens Healthcare GmbH, Quintiles GmbH, NovoCure, Pharmaceutical Research Associates GmbH, Boehringer Ingelheim Pharma GmbH Co., PTW-Freiburg Dr. Pychlau GmbH, Nanobiotix A.A., and IntraOP Medical (outside the submitted work). Uwe Haberkorn has a patent application for quinolone‐based FAP‐targeting agents for imaging and therapy in nuclear medicine and has shares of the consultancy group iTheranostics (outside the submitted work). No other potential conflict of interest relevant to this article was reported. 

