Calculating absolute risk from odds ratio, relative risk, or hazard ratio Say I have a known cumulative probability distribution for the probability (absolute risk) of developing breast cancer vs. age in a group representing the general population. I also know the odds ratio, relative risk, and hazard ratio for the development of breast cancer in a population that carries a cancer susceptibility gene mutation (ATM, for example). How would I calculate the cumulative probability distribution for the development of breast cancer vs. age in ATM mutation carriers?
I appreciate your help!

The odds ratio is how much more likely the group of interest is to develop cancer given that they carry ATM, right?
If you had the CDF for non-ATM carriers it would be trivial: simply multiply by odds ratio at each point in time and you would get separate curves for ATM carriers and non-carriers. The problem you're facing, then, is that the CDF you have contains data from both ATM carrying and non-carrying subjects.
If you know the fraction of ATM carriers in the general population, and if we can assume this holds also for the sample that makes up the CDF, you should be able to deconstruct it into carrying and non-carrying curves using the population proportion and the odds ratio -- if nothing else numerically. (With computer-intensive methods, you might even be able to get confidence bounds out of it.)
Note that this would only be possible because of a proportional hazards assumption, which simplifies the situation quite a lot. It's very important that you try to verify that assumption.
