How to prove this inequality? For any nonnegative random variable $X$ independent of $U$ where $U \sim \operatorname{Uniform}(-t,t)$ and any $t\ge 0,$
$$P(X+U\ge t)\le\frac{E(X)}{2t}.$$
Any hints to prove this inequality?

It's convenient to define $U$ once and for all to be a uniform variable on the interval $[-1,1]$ and simply multiply it by $t$ to produce the $U$ used in the question.
Two useful, easily proven, but not widely known facts about random variables $X$ in general are

*

*No matter what the distribution function (CDF) $F_X$ of $X$ might be, the random variable $X + tU$ is absolutely continuous with a density function $$f_{X+tU}(y) = \frac{1}{2t}\left(F_X(y+t) - F_X(y-t)\right).$$ There are many ways to prove this, as explained at https://stats.stackexchange.com/a/43075/919 (which concerns sums of the closely related uniform variable supported on $[0,1]$).


*The expectation of any non-negative random variable $X$ with CDF $F_X$ equals $$E[X] = \int_0^\infty \left[1 - F_X(x)\right]\,\mathrm{d} x.$$ This is repeatedly demonstrated in many threads here on CV; one is Expectation of a function of a random variable from CDF.  They all amount to performing an integration by parts.
With these facts in mind, evaluate the probability in the question as
$$\begin{aligned}
\Pr(X + tU \gt t) &= \int_t^\infty f_{X+tU}(y)\,\mathrm{d}y \\
&= \frac{1}{2t}\int_t^\infty \left(F_X(y+t) - F_X(y-t)\right)\,\mathrm{d}y\\
&= \frac{1}{2t}\int_t^\infty \left( \left[1 - F_X(y-t)\right] - \left[1 - F_X(y+t)\right]\right)\,\mathrm{d}y\\
&= \frac{1}{2t}\left(\int_0^\infty \left[1 - F_X(x)\right]\,\mathrm{d}x - \int_{2t}^\infty \left[1 - F_X(x)\right]\,\mathrm{d}x\right)\\
&= \frac{1}{2t}\left(E[X] - \int_{2t}^\infty \left[1 - F_X(x)\right]\,\mathrm{d}x\right)\\
&\le \frac{1}{2t} E[X].
\end{aligned}$$
The justifications of these steps are (1) definition of density, (2) fact $(1)$ above, (3) algebra, (4) linearity of integration followed by changes of variables, (5) fact $(2)$ above, and (6) since $1-F_X(x)$ is a probability for all $x,$ it is never negative, whence its integral is non-negative.
Finally, $\Pr(X + tU \ge t) = \Pr(X + tU \gt t)$ because (as previously noted) the variable $X + tU$ is absolutely continuous, QED.

One thing I like about this way of proceeding is the insight it provides into the tightness of the inequality: the amount by which the probability (on the left hand side) falls short of $E[X]/(2t)$ (on the right hand side) is proportional to the integral of $1-F_X$ from $2t$ on up.  Thus, for instance, when $X$ is bounded and $2t$ exceeds this bound, that integral is zero and the inequality becomes an equality.
