Determining the missing digits of $15! \equiv 1\square0767436\square000$ without actually calculating the factorial 
$$15! \equiv 1\cdot 2\cdot 3\cdot\,\cdots\,\cdot 15 \equiv 1\square0767436\square000$$
Using a calculator, I know that the answer is $3$ and $8$, but I know that the answer can be calculated by hand.

How to calculate the missing digits? I know that large factorials can be estimated using Stirling's approximation:
$$15! \approx \sqrt{2\pi\cdot 15}
\cdot \left(\frac{15}{e}\right)^{15}$$
which is not feasible to calculate by hand.
The resulting number must be divisible by 9 which means that the digit sum must add up to 9 and is also divisible by 11 which means that the alternating digit sum must be divisible by 11:
$1+ d_0 + 0 + 7 +6 +7 +4 +3+6+d_1+0+0+0 \mod \phantom{1}9 \equiv \,34 + d_0 + d_1 \mod \phantom{1}9 \equiv 0 $
$-1+ d_0 - 0 + 7 -6 +7 -4 +3-6+d_1-0+0-0 \mod 11 \equiv d_0 + d_1 \mod 11 \equiv 0 $
The digits $3$ and $8$, or $7$ and $4$, fulfill both of the requirements.

Another way to reason is to note that $15!$ is divisible by $2\cdot4\cdot2\cdot8\cdot2\cdot4\cdot2=2^{11}$, which means $1\square0767436\square$ is divisible by $2^8$.  In particular, it's divisible by $8$. But since $8\mid1000$ and $8\mid360$, the final $\square$ must be either $0$ or $8$.  But it can't be $0$, since $15!$ has only three powers of $5$ (from $5$, $10$, and $15$), and those were already accounted for in the final three $0$'s of the number.  Thus the final $\square$ is an $8$. Casting out $9$'s now reveals that the first $\square$ is a $3$.
Remark: It wasn't strictly necessary to determine the exact power of $2$ (namely $2^{11}$) that divides $15!$, merely that $2^6$ divides it, but it wasn't that hard to do.
