How to determine the coefficient of the main term of $S_{k}(x)$? Let $k\geqslant 2$ be an integer, suppose that $p_1,p_2,\dotsc,p_k$ are primes not exceeding $x$. Write
$$ S_{k}(x) = \sum_{p_1 \leqslant x} \dotsb \sum_{p_k \leqslant x} \frac{1}{p_1+\dotsb +p_k}.  $$
By AM-GM inequality, $p_{1}+\dotsb + p_{k} \geqslant k \sqrt[k]{p_{1}\dotsm p_{k}}$, we have
$$ S_{k}(x) \leqslant \frac{1}{k} \sum_{p_{1}\leqslant x}\dotsb \sum_{p_{k} \leqslant x}
 \frac{1}{\sqrt[k]{p_{1}\dotsm p_{k}}} = \frac{1}{k} \left( \sum_{p \leqslant x} p^{-\frac{1}{k}} \right)^{k}. $$
By Prime Number Theorem and summation by parts we see that
$$ \sum_{p \leqslant x} p^{-\frac{1}{k}} = \mathrm{Li}\big( x^{1-\frac{1}{k}} \big) + O \left( x^{1-\frac{1}{k}}\mathrm{e}^{-c\sqrt{\log x}} \right), $$
Here $\mathrm{Li}(x)$ is the logarithmic integral, and $\mathrm{Li}(x)\sim x/\log x$. Hence
$$ S_{k}(x) \leqslant \left( \frac{k^{k-1}}{(k-1)^{k}} +o(1) \right) \frac{x^{k-1}}{\log^{k} x}. $$
On the other hand, $p_{1}+\dotsb +p_{k} \leqslant kx$, we have
$$ S_{k}(x) \geqslant \frac{1}{kx} \sum_{p_{1} \leqslant x} \dotsb \sum_{p_{k} \leqslant x} 1 = \frac{1}{kx} \left( \sum_{p \leqslant x} 1 \right)^{k} = \frac{\pi^{k}(x)}{kx} = \frac{(1+o(1))}{k} \frac{x^{k-1}}{ \log^{k} x}. $$
My question is how to determine the coefficient of the main term of $S_{k}(x)$? Thanks!

Thank you, Mr. Petrov, but you made a little mistake.
A detailed calculation of $c$ is as follows:
Write $g(x)=(1-\mathrm{e}^{-x})^k= \sum\limits_{j=0}^{k} \binom{k}{j} (-1)^{j} \mathrm{e}^{-jx}$, integrating by parts we get
\begin{align}
\int_{0}^{\infty} g(x) x^{-k} \,\mathrm{d} x & = \int_{0}^{\infty} g(x) \,\mathrm{d} \left( \frac{x^{-k+1}}{-k+1} \right)  \nonumber \\
  & = \left. \frac{g(x)}{(-k+1)x^{k-1}} \right|_{0}^{\infty}
    + \frac{1}{k-1} \int_{0}^{\infty} \frac{g'(x)}{x^{k-1}} \mathrm{d} x,
\end{align}
since $\lim\limits_{x\to 0} \dfrac{g(x)}{x^{k-1}} = \lim\limits_{x\to +\infty} \dfrac{g(x)}{x^{k-1}} = 0$, so that
\begin{align*}
  \frac{1}{k-1} \int_{0}^{\infty} \frac{g'(x)}{x^{k-1}} \mathrm{d} x
  & = \frac{1}{k-1} \int_{0}^{\infty} g'(x) \, \mathrm{d} \left( \frac{x^{-k+2}}{-k+2} \right) \\
 & = - \left. \frac{g'(x)}{(k-1)(k-2)x^{k-2}} \right|_{0}^{\infty} + \frac{1}{(k-1)(k-2)} \int_{0}^{\infty} \frac{g''(x)}{x^{k-2}} \mathrm{d} x,
\end{align*}
where $g'(x)=k(1-\mathrm{e}^{-x})^{k-1}\cdot \mathrm{e}^{-x}$ and $\lim\limits_{x\to 0} \dfrac{-g'(x)}{(k-1)(k-2)x^{k-2}}= \lim\limits_{x\to +\infty} \dfrac{-g'(x)}{(k-1)(k-2)x^{k-2}}=0$. Hence, integrating by parts $k-1$ times gives
\begin{align}
   \int_{0}^{\infty}
      \frac{\sum\limits_{j=0}^{k} \binom{k}{j} (-1)^{j}\mathrm{e}^{-jx}}{x^k} \, \mathrm{d} x
 & =\frac{1}{(k-1)!}\int_{0}^{\infty} \frac{\sum\limits_{j=0}^{k} \binom{k}{j} (-1)^j(-j)^{k-1} \mathrm{e}^{-jx}}{x} \,\mathrm{d} x  \nonumber \\
& =\frac{1}{(k-1)!}\int_{0}^{\infty} \sum\limits_{j=1}^{k} \binom{k}{j} (-1)^{k+j-1}j^{k-1} \frac{\mathrm{e}^{-jx}}{x} \, \mathrm{d} x. \quad (\ast)
\end{align}
Notice that $(-1)^{k+j-1}=(-1)^{k+j+1}=-(-1)^{k-j}$, and consider the Stirling number of the second kind, we get
\begin{align}
\frac{1}{(k-1)!} \sum_{j=1}^{k} (-1)^{k+j-1} \binom{k}{j} j^{k-1}
 & = -k \cdot \frac{1}{k!} \sum_{j=1}^{k} (-1)^{k-j} \binom{k}{j} j^{k-1} \\
 & = -k\cdot S(k-1,k)=0.
\end{align}
Set $\displaystyle a_{j} = \frac{(-1)^{k+j-1}j^{k-1}}{(k-1)!} \binom{k}{j}$, then $\sum\limits_{j=1}^{k} a_{j}=0$.
Using the Frullani's integral formula $\int_{0}^{\infty} \frac{\mathrm{e}^{-jx}- \mathrm{e}^{-Ax}}{x} \mathrm{d} x = \log A - \log j$ with $0<j<A$.
Write $(\ast)$ as
\begin{align*}
  \int_{0}^{\infty} \sum_{j=1}^{k} a_{j} \frac{\mathrm{e}^{-jx}}{x} \mathrm{d} x
 & = \lim_{A\to + \infty} \int_{0}^{\infty} \sum_{j=1}^{k} a_{j}
    \frac{\mathrm{e}^{-jx}- \mathrm{e}^{-Ax}}{x} \mathrm{d} x  \\
 & = \lim_{A\to +\infty} \sum_{j=1}^{k} a_{j} (\log A - \log j)
  = - \sum_{j=1}^{k} a_{j} \log j,
\end{align*}
where $\lim\limits_{A\to +\infty} \sum\limits_{j=1}^{k} a_{j} \log A =0$. We obtain
$$ \int_{0}^{\infty} \left(\frac{1-\mathrm{e}^{-x}}{x}\right)^k \,\mathrm{d}x = c = \frac{1}{(k-1)!} \sum_{j=2}^{k} (-1)^{k+j} j^{k-1} \binom{k}{j} \log j. $$
