% Appendix B - details of fit
\chapter{Details of fitting}
\label{ch:fit-details}

\section{Analysis of TrmD in silico}
\label{sec:fit-details-trmd-theory}

\subsection{$C\alpha$ map, $T=0.3\epsilon$}
\label{subsec:trmd-ce}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_ce_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.2062$
        \item $k_{prot}=0.0041$
        \item states = 7 (30.1, 35.2, 57.0, 63.6, 65.3, 78.9, 90.8 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_ce_contour_lengths_1.png}
    \caption{All TrmD experimental traces ($C\alpha$ map, $T=0.3\epsilon$).}
    \label{fig:trmd-ce-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations ($C\alpha$ map, $T=0.3\epsilon$)}
    \label{tab:trmd-ce-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.203 & 0.004 & 9.9, 12.4, 13.7, 15.9, 19.5, 30.1, 31.2, 34.6, 37.7, 41.3, 44.1, 58.4, 65.0, 72.4, 78.8, 90.8\\
        2 & 0.205 & 0.004 & 10.8, 14.8, 19.9, 30.3, 34.5, 37.3, 43.2, 46.2, 57.8, 62.6, 65.2, 78.9, 90.8\\
        3 & 0.211 & 0.004 & 8.5, 11.1, 14.3, 19.6, 30.9, 34.3, 36.4, 40.0, 43.7, 55.6, 62.6, 65.4, 78.9, 90.9\\
        4 & 0.206 & 0.004 & 9.8, 13.4, 17.3, 20.8, 29.1, 30.7, 36.8, 43.0, 54.8, 60.4, 63.9, 65.3, 78.8, 90.8\\
        5 & 0.205 & 0.004 & 9.4, 12.6, 18.2, 30.5, 34.9, 38.3, 53.8, 62.4, 65.3, 72.9, 78.9, 90.9\\\hline
    \end{tabular}
\end{table}

\subsection{$C\alpha$ map, $T=0.4\epsilon$}
\label{subsec:trmd-cc}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_cc_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.4233$
        \item $k_{prot}=0.0060$
        \item states = 5 (33.6, 53.0, 62.8, 75.8, 90.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_cc_contour_lengths_1.png}
    \caption{All TrmD experimental traces ($C\alpha$ map, $T=0.4\epsilon$).}
    \label{fig:trmd-cc-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_cc_contour_lengths_2.png}
    \caption{All TrmD experimental traces ($C\alpha$ map, $T=0.4\epsilon$).}
    \label{fig:trmd-cc-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations ($C\alpha$ map, $T=0.4\epsilon$)}
    \label{tab:trmd-cc-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.325 & 0.006 & 17.4, 29.6, 31.7, 32.7, 35.7, 43.3, 51.5, 59.3, 63.1, 75.3, 89.5, 90.9\\
        2 & 0.339 & 0.007 & 14.5, 19.8, 27.6, 31.3, 34.8, 41.7, 52.3, 61.0, 64.8, 77.0, 90.9\\
        3 & 0.345 & 0.007 & 14.8, 20.3, 24.1, 31.8, 32.0, 34.5, 49.4, 51.2, 53.0, 59.6, 63.4, 65.2, 77.3, 90.9\\
        4 & 0.337 & 0.006 & 18.9, 28.0, 31.9, 35.1, 42.4, 49.0, 52.6, 62.7, 65.6, 70.3, 75.8, 76.9, 90.9, 152.9\\
        5 & 0.335 & 0.006 & 18.6, 32.3, 33.8, 43.6, 48.0, 52.2, 57.4, 60.0, 61.6, 63.3, 73.2, 75.1, 90.8\\
        6 & 0.338 & 0.006 & 23.4, 32.3, 33.2, 35.6, 45.2, 50.7, 53.5, 55.6, 58.4, 68.4, 73.8, 76.3, 90.9\\
        7 & 1.635 & 0.000 & 51.9, 55.6, 57.3, 59.9, 63.6, 65.8, 68.3, 72.7, 77.7, 84.7, 101.6, 111.1, 122.4\\
        8 & 0.340 & 0.007 & 23.1, 32.3, 33.4, 39.2, 40.9, 43.6, 51.6, 54.8, 56.9, 61.4, 64.4, 76.0, 90.9\\
        9 & 0.324 & 0.006 & 28.0, 32.4, 36.0, 51.0, 54.5, 57.7, 60.8, 63.5, 75.7, 90.8\\
        10 & 0.335 & 0.006 & 29.6, 32.4, 34.2, 50.9, 55.6, 58.9, 62.7, 64.5, 76.2, 78.2, 90.9\\
        11 & 0.334 & 0.006 & 28.0, 29.2, 33.3, 36.1, 51.0, 53.9, 56.4, 61.4, 64.1, 76.0, 89.6, 90.9\\
        12 & 0.339 & 0.007 & 27.0, 29.5, 35.1, 46.1, 51.1, 54.9, 66.2, 72.2, 74.8, 76.8, 90.9\\
        13 & 0.343 & 0.007 & 28.2, 32.7, 34.7, 41.7, 50.0, 52.3, 54.3, 57.0, 67.3, 72.6, 76.1, 90.9\\
        14 & 0.343 & 0.007 & 18.7, 32.6, 33.0, 35.9, 51.7, 55.9, 60.5, 69.5, 73.1, 90.9\\
        15 & 0.337 & 0.006 & 17.5, 27.9, 34.4, 43.6, 52.0, 52.8, 54.5, 56.9, 60.8, 68.2, 73.0, 76.0, 76.9, 90.9\\\hline
    \end{tabular}
\end{table}

\subsection{$C\alpha$ map, $T=0.5\epsilon$}
\label{subsec:trmd-ca}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_ca_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.4642$
        \item $k_{prot}=0.0077$
        \item states = 6 (44.9, 50.8, 62.2, 67.8, 71.1, 90.8 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_ca_contour_lengths_1.png}
    \caption{All TrmD experimental traces ($C\alpha$ map, $T=0.5\epsilon$).}
    \label{fig:trmd-ca-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations ($C\alpha$ map, $T=0.5\epsilon$)}
    \label{tab:trmd-ca-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.465 & 0.008 & 21.6, 27.4, 34.1, 35.8, 39.1, 41.7, 49.2, 64.5, 72.4, 87.4, 90.9\\
        2 & 0.456 & 0.007 & 24.4, 28.1, 30.7, 32.8, 35.9, 38.5, 45.7, 49.9, 51.9, 53.4, 58.2, 60.4, 62.0, 64.0, 66.3, 68.4, 70.4, 83.8, 89.5, 90.9\\
        3 & 0.455 & 0.007 & 21.5, 39.8, 43.0, 45.5, 48.5, 52.8, 61.9, 67.7, 71.7, 87.1, 90.9\\
        4 & 0.469 & 0.008 & 23.0, 26.1, 29.2, 31.3, 35.5, 38.4, 40.5, 43.5, 49.6, 51.3, 53.3, 57.5, 59.9, 61.6, 64.8, 70.6, 73.5, 83.7, 89.0, 90.9\\
        5 & 0.472 & 0.008 & 22.0, 28.9, 32.0, 37.5, 44.1, 50.1, 58.0, 60.2, 62.4, 64.3, 66.3, 69.3, 90.8\\
        6 & 0.479 & 0.008 & 20.8, 23.0, 25.1, 27.2, 30.9, 34.6, 36.4, 37.8, 44.0, 52.4, 52.5, 59.8, 63.5, 64.5, 66.9, 69.3, 71.0, 87.6, 90.9\\
        7 & 0.482 & 0.008 & 20.8, 23.6, 26.7, 29.8, 40.2, 42.3, 45.2, 50.6, 55.1, 59.7, 63.2, 65.2, 66.9, 69.4, 84.6, 89.3, 91.0\\
        8 & 0.449 & 0.007 & 15.8, 22.4, 26.2, 30.4, 33.8, 35.9, 39.3, 44.6, 45.7, 47.7, 50.3, 55.6, 61.8, 65.2, 66.8, 68.6, 83.9, 89.4, 90.9\\
        9 & 0.431 & 0.006 & 20.5, 28.9, 33.9, 36.8, 39.7, 45.1, 48.2, 51.6, 54.6, 58.5, 60.2, 66.2, 71.6, 87.3, 90.8\\
        10 & 0.484 & 0.009 & 22.2, 24.4, 26.4, 28.4, 32.9, 35.4, 38.1, 44.5, 52.6, 62.6, 66.0, 68.2, 70.4, 90.9\\\hline
    \end{tabular}
\end{table}

\subsection{$C\alpha$ map, $T=0.6\epsilon$}
\label{subsec:trmd-cb}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_cb_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.5861$
        \item $k_{prot}=0.0101$
        \item states = 2 (64.0, 90.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_cb_contour_lengths_1.png}
    \caption{All TrmD experimental traces ($C\alpha$ map, $T=0.6\epsilon$).}
    \label{fig:trmd-cb-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_cb_contour_lengths_2.png}
    \caption{All TrmD experimental traces ($C\alpha$ map, $T=0.6\epsilon$).}
    \label{fig:trmd-cb-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations ($C\alpha$ map, $T=0.6\epsilon$)}
    \label{tab:trmd-cb-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.594 & 0.008 & 19.4, 21.8, 24.1, 26.8, 29.6, 32.2, 34.8, 37.6, 40.8, 43.5, 46.5, 49.7, 55.9, 63.5, 69.3, 77.4, 85.8, 90.9\\
        2 & 0.602 & 0.009 & 23.1, 30.6, 36.3, 40.9, 44.5, 47.3, 50.3, 56.6, 64.5, 73.9, 80.5, 83.4, 87.8, 90.9\\
        3 & 0.324 & 0.008 & 18.3, 22.0, 23.9, 25.2, 27.6, 30.5, 33.1, 39.1, 44.7, 47.9, 51.5, 54.6, 56.5, 60.2, 74.3, 86.9, 90.9\\
        4 & 0.626 & 0.009 & 28.2, 31.3, 37.5, 42.8, 45.0, 47.6, 50.4, 53.3, 56.0, 58.7, 62.6, 66.5, 70.5, 75.3, 79.0, 82.1, 84.8, 90.8\\
        5 & 0.643 & 0.010 & 26.6, 28.8, 33.0, 35.3, 40.0, 44.5, 48.0, 51.0, 53.3, 57.9, 67.2, 81.3, 88.0, 90.9\\
        6 & 0.623 & 0.009 & 27.7, 32.1, 36.2, 40.1, 43.8, 47.7, 56.1, 62.7, 67.2, 84.2, 90.9\\
        7 & 0.483 & 0.015 & 17.9, 20.6, 23.4, 25.7, 27.7, 31.1, 35.7, 40.6, 42.9, 44.7, 52.3, 60.0, 61.4, 76.7, 90.9\\
        8 & 0.606 & 0.009 & 26.8, 33.8, 40.1, 43.4, 45.8, 47.9, 50.1, 58.2, 62.6, 67.2, 78.9, 85.8, 90.9\\
        9 & 0.648 & 0.010 & 30.3, 36.8, 43.2, 45.2, 46.6, 49.1, 50.6, 53.4, 57.6, 66.1, 80.2, 85.4, 90.0, 91.0\\
        10 & 0.625 & 0.009 & 31.5, 37.2, 40.7, 43.1, 45.0, 48.1, 50.3, 53.7, 57.7, 63.2, 75.3, 76.8, 79.6, 86.7, 90.2, 90.9, 92.1\\
        11 & 0.625 & 0.009 & 29.1, 31.3, 33.2, 35.4, 38.9, 42.4, 47.1, 49.7, 57.7, 66.1, 84.5, 90.9\\
        12 & 0.637 & 0.010 & 42.3, 45.9, 48.5, 58.0, 64.3, 67.2, 70.1, 77.9, 78.8, 86.5, 90.6, 91.0\\
        13 & 0.667 & 0.011 & 28.9, 33.3, 38.6, 44.1, 50.4, 59.3, 63.1, 66.8, 76.6, 82.7, 89.4, 91.1\\
        14 & 0.610 & 0.009 & 28.9, 37.6, 41.1, 44.3, 48.0, 53.1, 58.1, 61.7, 65.5, 74.0, 79.4, 85.9, 90.3, 90.9\\
        15 & 0.479 & 0.015 & 17.2, 20.8, 23.2, 26.8, 30.2, 51.3, 54.4, 55.5, 58.3, 62.2, 70.6, 74.1, 77.9, 83.8, 89.3, 91.0\\\hline
    \end{tabular}
\end{table}

\subsection{$C\alpha$ map, $T=0.5\epsilon$, $\kappa_S=0$}
\label{subsec:trmd-cd}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_cd_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.2660$
        \item $k_{prot}=0.0052$
        \item states = 5 (33.1, 55.4, 64.8, 78.5, 90.8 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_cd_contour_lengths_1.png}
    \caption{All TrmD experimental traces ($C\alpha$ map, $T=0.5\epsilon$, $\kappa_S=0$).}
    \label{fig:trmd-cd-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_cd_contour_lengths_2.png}
    \caption{All TrmD experimental traces ($C\alpha$ map, $T=0.5\epsilon$, $\kappa_S=0$).}
    \label{fig:trmd-cd-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations ($C\alpha$ map, $T=0.5\epsilon$, $\kappa_S=0$)}
    \label{tab:trmd-cd-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.267 & 0.005 & 10.5, 12.3, 13.9, 15.6, 18.1, 21.6, 25.5, 32.7, 47.8, 49.8, 52.1, 53.7, 55.7, 59.6, 64.8, 76.3, 78.4, 90.8\\
        2 & 0.263 & 0.005 & 14.0, 29.2, 31.2, 32.5, 35.8, 49.7, 50.5, 55.9, 62.8, 65.1, 72.3, 78.5, 90.8\\
        3 & 0.266 & 0.006 & 17.1, 29.7, 31.6, 35.1, 37.8, 50.1, 53.4, 56.2, 60.6, 63.8, 65.3, 78.6, 90.9\\
        4 & 0.271 & 0.005 & 11.9, 18.3, 29.7, 31.8, 35.7, 50.0, 53.6, 56.2, 63.9, 76.9, 78.6, 90.8\\
        5 & 0.264 & 0.005 & 12.3, 16.0, 22.0, 29.4, 31.8, 35.8, 41.4, 53.5, 57.1, 60.8, 63.9, 65.1, 78.5, 90.8\\
        6 & 0.269 & 0.005 & 13.0, 21.4, 32.4, 32.9, 37.2, 40.4, 53.9, 62.0, 64.9, 78.6, 90.9\\
        7 & 0.267 & 0.005 & 10.5, 18.6, 27.2, 29.9, 34.4, 40.1, 53.0, 56.5, 63.2, 65.3, 78.5, 90.8\\
        8 & 0.255 & 0.005 & 11.0, 15.7, 17.6, 18.5, 20.9, 32.9, 49.8, 52.4, 60.8, 65.0, 77.0, 78.7, 90.8\\
        9 & 0.266 & 0.005 & 16.6, 26.7, 32.6, 36.3, 39.1, 52.9, 57.7, 64.8, 76.6, 78.7, 90.8\\
        10 & 0.265 & 0.005 & 11.1, 14.5, 17.5, 24.7, 26.7, 31.5, 33.5, 36.7, 44.0, 51.6, 55.6, 57.8, 60.8, 64.9, 78.7, 90.8\\
        11 & 0.264 & 0.005 & 10.6, 13.1, 15.3, 17.3, 19.5, 21.0, 28.8, 31.9, 35.6, 37.8, 52.2, 58.0, 60.7, 63.6, 65.2, 72.3, 78.6, 90.8\\
        12 & 0.263 & 0.005 & 9.3, 13.1, 15.4, 17.6, 19.3, 27.8, 30.1, 34.5, 38.6, 52.1, 54.8, 58.2, 62.7, 65.0, 77.6, 78.8, 90.9\\
        13 & 0.274 & 0.006 & 14.5, 18.6, 21.6, 25.9, 30.5, 32.2, 35.3, 42.6, 52.3, 61.1, 64.9, 76.8, 90.0, 90.9\\
        14 & 0.266 & 0.005 & 11.0, 13.6, 22.1, 28.9, 31.3, 35.1, 40.9, 54.0, 58.4, 63.9, 65.1, 78.4, 90.8\\
        15 & 0.270 & 0.005 & 15.2, 17.1, 21.2, 32.3, 32.4, 35.8, 50.2, 55.1, 63.1, 65.1, 78.5, 90.8\\\hline
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.4\epsilon$}
\label{subsec:trmd-pc}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_pc_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.3968$
        \item $k_{prot}=0.0048$
        \item states = 8 (8.4, 25.7, 40.6, 58.0, 63.1, 65.6, 77.6, 90.8 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_pc_contour_lengths_1.png}
    \caption{All TrmD experimental traces (Tsai map, $T=0.4\epsilon$).}
    \label{fig:trmd-pc-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_pc_contour_lengths_2.png}
    \caption{All TrmD experimental traces (Tsai map, $T=0.4\epsilon$).}
    \label{fig:trmd-pc-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations (Tsai map, $T=0.4\epsilon$)}
    \label{tab:trmd-pc-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.400 & 0.005 & 8.5, 18.3, 25.8, 30.7, 38.4, 44.0, 60.1, 65.6, 77.5, 89.9, 90.9\\
        2 & 0.402 & 0.005 & 8.4, 24.8, 30.8, 40.6, 44.0, 56.2, 61.3, 65.1, 66.3, 78.1, 90.9\\
        3 & 0.409 & 0.005 & 8.3, 10.6, 24.5, 30.6, 39.1, 42.5, 58.2, 64.6, 66.4, 77.8, 90.8\\
        4 & 0.404 & 0.005 & 8.5, 10.7, 25.6, 37.8, 41.2, 44.6, 58.3, 63.8, 77.4, 90.8\\
        5 & 0.402 & 0.005 & 8.4, 24.5, 27.5, 31.5, 40.3, 53.6, 54.7, 58.7, 62.2, 64.4, 66.1, 78.0, 89.4, 90.9\\
        6 & 0.403 & 0.005 & 8.1, 9.4, 13.3, 25.5, 31.6, 40.8, 44.2, 57.1, 60.9, 63.6, 76.2, 90.8\\
        7 & 0.390 & 0.004 & 8.2, 11.2, 23.2, 26.3, 30.6, 38.9, 42.3, 56.8, 62.3, 74.4, 78.0, 90.8\\
        8 & 0.400 & 0.005 & 8.3, 13.7, 25.7, 37.3, 41.3, 44.7, 56.6, 62.9, 66.0, 77.9, 90.2, 90.9\\
        9 & 0.343 & 0.007 & 8.1, 17.2, 24.7, 29.8, 37.3, 42.3, 54.2, 59.5, 64.0, 76.5, 90.9\\
        10 & 0.399 & 0.005 & 8.3, 10.5, 17.1, 25.5, 36.7, 38.5, 40.9, 44.8, 58.1, 62.6, 77.8, 90.8\\
        11 & 0.399 & 0.005 & 8.4, 24.8, 30.6, 40.3, 44.5, 57.5, 62.6, 73.7, 77.7, 90.8\\
        12 & 0.399 & 0.004 & 8.7, 25.2, 30.2, 36.7, 40.9, 55.5, 57.9, 62.9, 76.2, 89.4, 90.9\\
        13 & 0.405 & 0.005 & 8.2, 10.6, 25.2, 30.8, 39.1, 43.5, 56.8, 62.4, 65.4, 77.8, 90.5, 90.9\\
        14 & 0.403 & 0.005 & 8.4, 10.6, 24.8, 27.9, 29.2, 31.7, 41.0, 43.4, 45.2, 57.3, 62.4, 65.5, 77.8, 90.8, 95.0\\
        15 & 0.396 & 0.004 & 8.5, 25.0, 30.3, 38.1, 41.0, 43.9, 56.0, 60.0, 69.0, 74.5, 78.0, 90.8\\\hline
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.5\epsilon$}
\label{subsec:trmd-pa}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_pa_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.4821$
        \item $k_{prot}=0.0072$
        \item states = 8 (9.2, 24.7, 36.0, 52.3, 65.0, 71.5, 74.3, 90.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_pa_contour_lengths_1.png}
    \caption{All TrmD experimental traces (Tsai map, $T=0.5\epsilon$).}
    \label{fig:trmd-pa-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations (Tsai map, $T=0.5\epsilon$)}
    \label{tab:trmd-pa-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.460 & 0.007 & 9.2, 13.0, 16.6, 21.1, 25.2, 35.6, 45.7, 49.2, 56.4, 60.2, 62.0, 64.8, 71.6, 90.8\\
        2 & 0.463 & 0.007 & 8.9, 13.2, 23.7, 26.5, 35.9, 50.7, 54.3, 61.0, 61.8, 66.5, 70.7, 72.1, 75.0, 87.9, 90.9\\
        3 & 0.445 & 0.007 & 8.6, 10.9, 16.0, 21.8, 26.2, 35.8, 50.5, 62.5, 65.9, 71.4, 73.9, 90.8\\
        4 & 0.563 & 0.007 & 9.3, 10.3, 19.9, 25.8, 30.0, 36.8, 54.3, 65.3, 70.9, 76.1, 90.9\\
        5 & 0.538 & 0.006 & 8.6, 10.2, 22.0, 26.3, 37.1, 52.2, 59.7, 66.8, 72.1, 73.8, 76.3, 88.8, 90.9\\
        6 & 0.462 & 0.007 & 9.4, 12.3, 15.1, 20.6, 25.5, 35.3, 51.8, 60.5, 63.8, 67.1, 69.1, 72.0, 88.1, 90.9\\
        7 & 0.462 & 0.007 & 9.0, 13.2, 16.7, 18.8, 24.7, 36.4, 50.6, 60.3, 62.7, 65.0, 66.9, 69.0, 71.2, 74.5, 90.8\\
        8 & 0.483 & 0.008 & 9.1, 12.7, 23.9, 35.2, 47.0, 47.7, 57.1, 61.0, 64.0, 69.5, 83.2, 89.3, 91.0\\
        9 & 0.469 & 0.008 & 9.0, 19.2, 25.2, 36.5, 60.9, 64.1, 67.2, 70.5, 72.6, 73.5, 74.7, 88.8, 90.9\\
        10 & 0.474 & 0.008 & 9.2, 12.4, 20.1, 22.4, 25.2, 35.5, 49.3, 60.4, 67.6, 70.1, 73.6, 90.9\\\hline
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.6\epsilon$}
\label{subsec:trmd-pb}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_pb_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.6279$
        \item $k_{prot}=0.0092$
        \item states = 4 (34.4, 36.4, 64.4, 90.8 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_pb_contour_lengths_1.png}
    \caption{All TrmD experimental traces (Tsai map, $T=0.6\epsilon$).}
    \label{fig:trmd-pb-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_pb_contour_lengths_2.png}
    \caption{All TrmD experimental traces (Tsai map, $T=0.6\epsilon$).}
    \label{fig:trmd-pb-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations (Tsai map, $T=0.6\epsilon$)}
    \label{tab:trmd-pb-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.598 & 0.008 & 10.3, 13.1, 17.1, 24.2, 28.0, 29.9, 31.9, 33.9, 36.9, 38.4, 43.4, 49.6, 53.2, 60.1, 66.5, 77.1, 84.1, 89.0, 90.9\\
        2 & 0.646 & 0.010 & 9.9, 12.0, 13.9, 17.1, 20.3, 23.0, 25.5, 28.1, 31.3, 34.9, 40.4, 44.3, 45.7, 47.2, 55.1, 62.2, 65.8, 69.2, 84.9, 90.9\\
        3 & 0.601 & 0.008 & 11.1, 15.4, 18.6, 21.0, 21.9, 25.4, 30.3, 32.3, 34.4, 36.8, 39.3, 44.1, 53.4, 63.0, 69.3, 70.7, 85.0, 89.7, 90.9\\
        4 & 0.646 & 0.010 & 12.5, 23.9, 28.4, 30.2, 34.6, 36.4, 38.4, 40.7, 44.0, 60.5, 60.6, 64.8, 69.1, 83.7, 89.5, 91.0\\
        5 & 0.627 & 0.009 & 11.2, 14.6, 18.0, 24.6, 29.7, 32.5, 34.1, 35.6, 37.8, 43.1, 52.2, 59.3, 61.8, 64.4, 70.5, 76.2, 84.5, 90.9\\
        6 & 0.650 & 0.010 & 11.4, 14.9, 17.9, 22.6, 25.5, 28.6, 33.8, 37.4, 39.9, 49.2, 66.2, 90.8\\
        7 & 0.637 & 0.010 & 11.4, 15.4, 18.0, 20.3, 22.9, 25.3, 27.0, 30.7, 34.3, 38.8, 44.9, 47.2, 49.6, 56.5, 61.1, 63.0, 66.7, 75.0, 80.9, 88.2, 91.0\\
        8 & 0.639 & 0.009 & 10.5, 12.4, 14.0, 17.3, 22.3, 25.4, 28.6, 31.2, 33.7, 37.3, 41.2, 44.1, 46.4, 48.5, 50.5, 52.1, 56.9, 65.6, 74.5, 86.0, 90.9\\
        9 & 0.615 & 0.009 & 9.9, 11.9, 14.8, 18.9, 23.6, 27.1, 33.1, 35.7, 38.1, 40.0, 45.5, 50.0, 53.7, 58.7, 62.7, 66.7, 81.0, 86.2, 89.6, 90.9\\
        10 & 0.605 & 0.009 & 8.6, 11.3, 13.7, 18.8, 22.7, 26.0, 30.3, 35.2, 40.1, 52.4, 59.3, 61.6, 65.9, 81.5, 85.3, 89.0, 90.9\\
        11 & 0.638 & 0.010 & 13.6, 18.6, 22.9, 25.9, 28.4, 31.7, 35.7, 36.0, 52.7, 57.6, 59.3, 62.5, 66.6, 73.8, 73.8, 84.5, 89.9, 90.9\\
        12 & 0.643 & 0.010 & 12.7, 17.4, 20.2, 23.6, 28.2, 32.1, 35.9, 42.3, 58.7, 63.7, 65.7, 69.1, 83.8, 89.4, 91.0\\
        13 & 0.580 & 0.008 & 10.4, 15.3, 17.1, 21.9, 24.6, 26.8, 29.4, 34.2, 37.5, 44.0, 48.3, 54.4, 58.8, 64.8, 84.3, 89.2, 90.9\\
        14 & 0.642 & 0.010 & 12.4, 15.3, 20.7, 24.8, 26.9, 28.7, 31.3, 36.4, 42.9, 47.7, 50.3, 52.9, 55.4, 58.2, 61.8, 65.5, 73.3, 82.2, 88.8, 90.9\\
        15 & 0.652 & 0.010 & 10.6, 13.6, 19.5, 24.7, 29.0, 34.0, 36.5, 39.1, 41.3, 43.2, 44.7, 55.5, 65.3, 69.0, 90.9\\\hline
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.5\epsilon$, $\kappa_S=0$}
\label{subsec:trmd-pd}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_pd_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.2927$
        \item $k_{prot}=0.0118$
        \item states = 18 (8.4, 17.1, 21.7, 25.7, 35.2, 37.5, 47.2, 48.8, 50.4, 52.5, 55.7, 64.3, 67.7, 70.5, 73.7, 78.3, 83.2, 90.5 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_pd_contour_lengths_1.png}
    \caption{All TrmD experimental traces (Tsai map, $T=0.5\epsilon$, $\kappa_S=0$).}
    \label{fig:trmd-pd-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations (Tsai map, $T=0.5\epsilon$, $\kappa_S=0$)}
    \label{tab:trmd-pd-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.000 & 0.027 & 5.6, 7.6, 12.3, 19.3, 20.8, 23.5, 26.4, 29.9, 31.5, 32.2, 35.3, 37.8, 40.4, 42.2, 44.8, 46.6, 47.6, 49.0, 52.2, 53.7, 56.9, 59.7, 61.3, 66.2, 72.4, 74.9\\
        2 & 0.440 & 0.002 & 8.3, 11.4, 15.7, 18.3, 21.2, 23.7, 26.3, 31.7, 34.5, 38.0, 51.3, 52.4, 54.4, 56.1, 57.6, 59.9, 67.1, 72.4, 76.9, 80.1, 83.5, 88.5, 90.8\\
        3 & 0.361 & 0.004 & 8.2, 14.3, 18.0, 20.3, 24.6, 27.3, 32.2, 36.5, 40.6, 46.4, 50.5, 52.8, 56.4, 59.7, 62.4, 64.4, 67.2, 69.0, 71.3, 73.9, 81.8, 88.5, 90.7\\
        4 & 0.388 & 0.004 & 8.4, 11.5, 14.7, 22.8, 26.1, 34.6, 36.9, 48.2, 52.1, 53.5, 56.4, 62.9, 63.6, 67.6, 71.8, 78.9, 83.3, 86.0, 89.3, 90.7\\
        5 & 0.455 & 0.003 & 9.1, 12.7, 16.3, 20.1, 21.9, 26.5, 30.9, 36.1, 45.4, 46.4, 48.3, 54.3, 57.7, 60.3, 63.3, 65.7, 66.9, 68.3, 71.8, 75.8, 77.5, 83.6, 89.1, 90.7\\
        6 & 0.011 & 0.016 & 6.3, 10.1, 13.1, 16.1, 17.8, 19.4, 20.7, 22.7, 25.2, 27.0, 28.7, 30.6, 34.4, 37.7, 39.5, 41.2, 45.9, 48.7, 50.7, 54.0, 57.4, 61.8, 66.6, 68.4, 70.1, 73.5, 77.7, 79.3\\
        7 & 0.467 & 0.003 & 8.2, 9.5, 15.8, 23.2, 25.3, 27.2, 34.8, 38.2, 45.8, 47.0, 50.9, 52.5, 54.0, 56.6, 65.0, 67.5, 70.9, 75.0, 83.9, 86.4, 89.5, 90.8\\
        8 & 0.000 & 0.031 & 5.9, 9.1, 15.4, 18.5, 20.3, 21.9, 25.7, 29.0, 31.0, 34.6, 38.3, 40.6, 42.6, 44.9, 47.7, 50.6, 52.6, 55.5, 58.9, 62.8, 65.8, 68.8, 71.5, 73.8\\
        9 & 0.078 & 0.011 & 7.2, 10.3, 12.8, 18.3, 21.6, 24.1, 29.3, 31.9, 33.9, 38.6, 41.2, 42.6, 48.0, 50.4, 52.7, 56.8, 59.2, 63.8, 67.4, 70.4, 72.8, 78.1, 82.9\\
        10 & 0.027 & 0.018 & 6.8, 11.0, 13.1, 15.2, 18.7, 21.7, 24.6, 28.1, 31.2, 33.8, 37.9, 41.4, 43.6, 46.3, 49.9, 53.0, 56.4, 59.0, 61.0, 67.2, 70.8, 75.4, 78.2\\\hline
    \end{tabular}
\end{table}

\subsection{SMOG map, $T=0.4\epsilon$}
\label{subsec:trmd-sc}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_sc_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.2312$
        \item $k_{prot}=0.0073$
        \item states = 3 (6.2, 45.8, 88.4 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_sc_contour_lengths_1.png}
    \caption{All TrmD experimental traces (SMOG map, $T=0.4\epsilon$).}
    \label{fig:trmd-sc-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_sc_contour_lengths_2.png}
    \caption{All TrmD experimental traces (SMOG map, $T=0.4\epsilon$).}
    \label{fig:trmd-sc-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations (SMOG map, $T=0.4\epsilon$)}
    \label{tab:trmd-sc-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.144 & 0.009 & 5.9, 13.7, 29.6, 31.6, 35.1, 44.2, 57.4, 68.5, 73.5, 80.8, 85.4\\
        2 & 0.347 & 0.005 & 6.6, 14.4, 26.5, 33.9, 38.2, 46.9, 72.7, 77.9, 90.1\\
        3 & 0.016 & 0.015 & 5.1, 12.6, 20.6, 26.9, 29.8, 32.9, 41.3, 64.0, 69.0, 80.1\\
        4 & 0.321 & 0.005 & 6.5, 14.7, 28.5, 33.4, 37.5, 46.7, 60.5, 72.4, 77.5, 85.0, 89.7\\
        5 & 0.320 & 0.005 & 0.0, 6.5, 15.2, 27.0, 31.2, 34.0, 37.4, 46.7, 60.7, 72.3, 77.5, 85.2, 89.8\\
        6 & 0.179 & 0.009 & 6.0, 13.9, 24.1, 29.1, 32.1, 35.5, 44.8, 58.2, 69.3, 74.4, 86.2\\
        7 & 0.373 & 0.004 & 6.7, 14.6, 30.0, 34.1, 38.2, 47.3, 61.5, 73.2, 78.4, 90.9\\
        8 & 0.161 & 0.009 & 6.0, 13.6, 23.4, 29.5, 32.3, 35.9, 44.5, 57.9, 68.9, 74.0, 85.8\\
        9 & 0.255 & 0.007 & 6.3, 14.0, 27.2, 32.2, 33.5, 37.1, 45.8, 59.4, 71.0, 76.1, 88.1\\
        10 & 0.093 & 0.012 & 5.6, 13.0, 27.3, 31.0, 35.0, 43.2, 56.1, 67.0, 72.0, 83.5\\
        11 & 0.297 & 0.004 & 6.5, 14.1, 30.5, 33.8, 38.0, 46.5, 72.0, 77.2, 90.9\\
        12 & 0.177 & 0.009 & 6.0, 13.8, 27.8, 31.8, 35.7, 44.7, 58.1, 69.3, 74.3, 86.2\\
        13 & 0.254 & 0.007 & 6.3, 14.6, 30.4, 33.3, 37.1, 45.8, 71.1, 76.1, 88.1\\
        14 & 0.252 & 0.007 & 6.3, 14.1, 25.8, 32.6, 36.7, 45.7, 70.8, 75.9, 87.9\\
        15 & 0.278 & 0.006 & 0.0, 6.5, 14.3, 29.5, 33.1, 36.7, 46.1, 59.9, 71.5, 76.7, 88.8\\\hline
    \end{tabular}
\end{table}

\subsection{SMOG map, $T=0.5\epsilon$}
\label{subsec:trmd-sa}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_sa_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.4815$
        \item $k_{prot}=0.0059$
        \item states = 3 (46.9, 77.8, 90.5 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_sa_contour_lengths_1.png}
    \caption{All TrmD experimental traces (SMOG map, $T=0.5\epsilon$).}
    \label{fig:trmd-sa-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations (SMOG map, $T=0.5\epsilon$)}
    \label{tab:trmd-sa-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.358 & 0.008 & 6.9, 12.8, 24.0, 31.4, 36.1, 45.4, 69.9, 75.5, 88.4\\
        2 & 0.512 & 0.005 & 7.5, 13.2, 24.1, 31.7, 34.0, 37.9, 47.2, 73.4, 78.1, 90.9\\
        3 & 0.475 & 0.006 & 7.3, 12.9, 24.0, 27.1, 32.4, 35.7, 37.2, 46.8, 71.8, 77.7, 89.9, 90.2\\
        4 & 0.514 & 0.005 & 7.4, 13.6, 24.6, 30.0, 33.7, 37.5, 47.2, 72.5, 78.4, 90.8\\
        5 & 0.518 & 0.005 & 7.4, 12.5, 26.5, 33.0, 38.0, 47.3, 72.9, 78.5, 90.8, 90.9\\
        6 & 0.530 & 0.006 & 7.7, 13.1, 25.5, 28.8, 32.9, 37.7, 47.3, 66.3, 78.2, 90.9\\
        7 & 0.515 & 0.005 & 7.5, 13.5, 29.4, 31.6, 34.2, 47.0, 60.4, 73.3, 78.1, 90.0, 90.9\\
        8 & 0.515 & 0.005 & 7.2, 8.1, 13.1, 23.5, 29.7, 33.1, 37.6, 47.3, 61.2, 78.2, 90.9\\
        9 & 0.448 & 0.007 & 7.3, 12.6, 28.0, 32.9, 37.1, 46.5, 77.0, 86.0, 89.6\\
        10 & 0.429 & 0.007 & 7.1, 11.9, 14.6, 27.5, 32.2, 36.7, 45.9, 59.1, 69.9, 76.6, 88.7, 89.3\\\hline
    \end{tabular}
\end{table}

\subsection{SMOG map, $T=0.6\epsilon$}
\label{subsec:trmd-sb}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_sb_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.6131$
        \item $k_{prot}=0.0063$
        \item states = 3 (45.9, 75.9, 90.8 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_sb_contour_lengths_1.png}
    \caption{All TrmD experimental traces (SMOG map, $T=0.6\epsilon$).}
    \label{fig:trmd-sb-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_sb_contour_lengths_2.png}
    \caption{All TrmD experimental traces (SMOG map, $T=0.6\epsilon$).}
    \label{fig:trmd-sb-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations (SMOG map, $T=0.6\epsilon$)}
    \label{tab:trmd-sb-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.578 & 0.008 & 8.5, 12.6, 28.2, 30.9, 32.2, 35.5, 45.4, 75.3, 90.8\\
        2 & 0.594 & 0.004 & 8.6, 11.7, 13.3, 23.0, 30.1, 45.8, 72.9, 76.3, 90.7\\
        3 & 0.601 & 0.009 & 8.5, 12.6, 29.5, 45.6, 75.2, 89.0, 90.9, 139.6\\
        4 & 0.613 & 0.004 & 8.6, 12.4, 24.1, 29.6, 31.0, 45.3, 71.6, 76.5, 90.7\\
        5 & 0.608 & 0.004 & 8.4, 12.3, 29.3, 29.7, 35.6, 46.1, 76.1, 89.5, 90.9\\
        6 & 0.591 & 0.004 & 8.2, 11.8, 22.4, 24.8, 29.8, 36.8, 46.2, 69.0, 75.2, 90.6\\
        7 & 0.593 & 0.008 & 8.3, 10.4, 13.9, 29.6, 36.2, 45.6, 75.3, 90.8\\
        8 & 0.595 & 0.004 & 8.3, 12.4, 25.9, 31.7, 44.4, 46.4, 74.8, 88.7, 90.8\\
        9 & 0.587 & 0.008 & 8.5, 13.0, 27.4, 30.6, 44.8, 72.4, 75.1, 89.3, 90.9\\
        10 & 0.689 & 0.007 & 8.9, 13.6, 28.7, 32.7, 36.7, 46.5, 73.7, 77.4, 90.8\\
        11 & 0.692 & 0.007 & 9.2, 13.2, 25.5, 28.0, 31.6, 36.6, 46.7, 77.5, 79.1, 90.9\\
        12 & 0.585 & 0.008 & 9.0, 12.9, 24.9, 29.7, 35.6, 45.6, 71.2, 76.0, 90.9\\
        13 & 0.675 & 0.007 & 9.0, 13.8, 30.4, 32.6, 46.6, 77.3, 90.8, 94.0\\
        14 & 0.590 & 0.009 & 8.4, 12.3, 24.9, 27.4, 30.1, 34.9, 44.3, 46.3, 74.6, 90.8\\
        15 & 0.604 & 0.004 & 8.7, 10.8, 13.0, 23.1, 28.2, 31.7, 46.0, 73.4, 76.5, 90.7\\\hline
    \end{tabular}
\end{table}

\subsection{SMOG map, $T=0.5\epsilon$, $\kappa_S=0$}
\label{subsec:trmd-sd}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd_sd_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.2397$
        \item $k_{prot}=0.0144$
        \item states = 15 (7.6, 12.5, 15.7, 19.9, 26.8, 31.7, 37.2, 44.9, 47.1, 52.5, 60.9, 67.1, 72.0, 78.1, 90.3 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd_sd_contour_lengths_1.png}
    \caption{All TrmD experimental traces (SMOG map, $T=0.5\epsilon$, $\kappa_S=0$).}
    \label{fig:trmd-sd-cl1}
\end{figure}

\begin{table}
    \centering
    \caption{Parameters of TrmD fitting in simulations (SMOG map, $T=0.5\epsilon$, $\kappa_S=0$)}
    \label{tab:trmd-sd-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.000 & 0.003 & 6.5, 10.8, 28.7, 35.5, 38.8, 40.8, 43.5, 45.4, 50.7, 53.8, 56.3, 58.8, 60.8, 64.6, 66.6, 67.7, 69.9, 73.6, 79.6, 80.9, 81.7\\
        2 & 2.026 & 0.000 & 11.7, 22.6, 29.8, 32.9, 34.8, 36.7, 40.0, 44.0, 46.9, 50.9, 57.9, 60.7, 64.3, 70.4, 73.9, 76.1, 78.6, 80.7, 82.8, 85.9, 88.0, 91.2, 98.4, 103.3, 106.7, 112.4, 112.4, 117.4, 121.0\\
        3 & 0.028 & 0.010 & 9.6, 16.4, 19.6, 25.2, 27.1, 29.9, 32.7, 37.8, 41.4, 46.5, 48.8, 51.8, 55.6, 59.6, 61.0, 64.4, 67.7, 72.0, 77.5, 80.8\\
        4 & 0.000 & 0.008 & 13.0, 23.0, 25.9, 28.2, 30.3, 32.0, 34.0, 35.8, 38.4, 40.6, 43.5, 46.5, 50.8, 52.5, 54.8, 57.3, 59.3, 61.5, 64.0, 66.3, 69.6, 74.9, 79.3\\
        5 & 0.425 & 0.000 & 7.8, 12.9, 15.0, 17.6, 20.4, 24.7, 28.0, 30.7, 32.9, 36.5, 46.3, 54.8, 57.6, 60.6, 64.8, 73.7, 77.2, 84.4, 90.8, 92.6\\
        6 & 0.432 & 0.002 & 7.7, 12.4, 15.4, 24.7, 28.3, 33.0, 37.9, 44.8, 47.0, 53.9, 60.9, 63.4, 74.1, 77.0, 87.8, 90.5\\
        7 & 0.002 & 0.005 & 5.7, 8.3, 16.7, 19.5, 22.8, 25.3, 27.8, 30.9, 34.2, 37.5, 39.5, 41.1, 45.0, 48.5, 50.8, 53.9, 56.3, 57.5, 59.4, 63.4, 64.5, 66.5, 67.9, 70.1, 71.0, 73.2, 78.5, 80.9, 81.9\\
        8 & 0.593 & 0.006 & 8.1, 14.4, 20.4, 23.3, 26.1, 30.3, 33.4, 35.1, 37.5, 44.1, 47.7, 48.0, 52.0, 54.0, 59.0, 62.4, 64.8, 66.3, 68.0, 69.8, 73.3, 79.0, 87.3, 91.6, 91.9\\
        9 & 0.001 & 0.006 & 5.5, 7.7, 14.9, 21.5, 28.2, 31.6, 38.0, 40.8, 44.2, 47.0, 50.5, 54.2, 56.2, 58.2, 59.4, 61.5, 65.1, 67.0, 69.8, 74.2, 79.3, 80.6\\
        10 & 0.469 & 0.004 & 7.0, 8.2, 13.2, 15.6, 22.7, 26.7, 30.0, 31.9, 33.0, 34.0, 37.2, 46.4, 57.1, 60.4, 63.7, 76.4, 90.0\\\hline
    \end{tabular}
\end{table}

\section{Analysis of no-knot-TrmD in silico}
\label{sec:fit-details-no-knot-trmd-theory}
\subsection{$C\alpha$ map, $T=0.4\epsilon$}
\label{subsec:no-knot-trmd-cc}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd-no-knot_cc_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.2450$
        \item $k_{prot}=0.0161$
        \item states = 10 (30.1, 35.6, 37.7, 40.3, 47.6, 50.7, 66.7, 77.8, 89.0, 90.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd-no-knot_cc_contour_lengths_1.png}
    \caption{All no-knot-TrmD experimental traces ($C\alpha$ map, $T=0.4\epsilon$).}
    \label{fig:no-knot-trmd-cc-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of no-knot-TrmD fitting in simulations ($C\alpha$ map, $T=0.4\epsilon$)}
    \label{tab:no-knot-trmd-cc-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.199 & 0.012 & 13.2, 21.3, 24.3, 28.6, 35.6, 39.3, 43.6, 50.1, 54.3, 57.0, 60.0, 65.0, 65.4, 76.9, 78.4, 90.6\\
        2 & 0.250 & 0.016 & 10.8, 18.5, 23.9, 29.5, 38.1, 42.3, 45.1, 51.2, 55.4, 61.4, 65.4, 68.0, 70.3, 72.1, 76.8, 90.9\\
        3 & 0.276 & 0.019 & 16.1, 29.1, 31.4, 35.5, 39.8, 43.9, 47.9, 50.5, 68.8, 71.9, 75.3, 78.1, 79.4, 88.6, 91.0\\
        4 & 0.246 & 0.016 & 17.6, 25.6, 30.8, 36.4, 42.0, 48.8, 51.0, 52.2, 55.9, 60.4, 64.1, 75.3, 76.2, 85.0, 89.4, 90.9\\
        5 & 0.254 & 0.017 & 11.8, 18.7, 24.9, 30.6, 37.3, 41.2, 45.5, 64.6, 68.3, 71.3, 81.8, 88.8, 90.9\\
    \end{tabular}
\end{table}

\subsection{$C\alpha$ map, $T=0.5\epsilon$}
\label{subsec:no-knot-trmd-ca}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd-no-knot_ca_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.3977$
        \item $k_{prot}=0.0195$
        \item states = 11 (49.1, 54.0, 59.4, 63.3, 67.5, 70.3, 73.8, 80.6, 86.8, 89.5, 91.0 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd-no-knot_ca_contour_lengths_1.png}
    \caption{All no-knot-TrmD experimental traces ($C\alpha$ map, $T=0.5\epsilon$).}
    \label{fig:no-knot-trmd-ca-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of TrmD fitting in simulations ($C\alpha$ map, $T=0.5\epsilon$)}
    \label{tab:no-knot-trmd-ca-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.422 & 0.021 & 17.9, 20.9, 24.2, 28.7, 31.8, 35.5, 39.9, 42.9, 45.9, 48.4, 49.5, 51.6, 55.3, 58.5, 61.8, 66.6, 72.5, 75.4, 79.8, 80.2, 87.1, 90.4, 91.0\\
        2 & 0.463 & 0.027 & 25.4, 27.5, 29.7, 32.3, 34.0, 35.6, 37.6, 40.0, 42.6, 45.3, 47.4, 49.3, 51.9, 54.2, 59.4, 60.9, 63.2, 67.7, 68.9, 72.0, 74.9, 77.0, 80.3, 87.9, 89.2, 90.9\\
        3 & 0.328 & 0.012 & 22.8, 26.8, 31.7, 35.2, 40.5, 43.4, 45.9, 49.4, 53.0, 54.9, 56.4, 58.1, 60.7, 64.9, 68.0, 70.4, 73.4, 75.8, 80.0, 87.0, 89.8, 91.4\\
        4 & 0.380 & 0.018 & 18.0, 23.0, 25.7, 28.6, 31.8, 34.1, 39.3, 44.4, 47.7, 53.8, 59.1, 62.6, 69.3, 71.1, 73.6, 75.9, 84.2, 89.5, 90.9\\
        5 & 0.395 & 0.019 & 29.0, 32.3, 34.6, 37.4, 41.5, 44.3, 58.8, 59.6, 62.2, 66.9, 74.9, 79.8, 84.8, 90.0, 90.9, 92.0\\
    \end{tabular}
\end{table}

\subsection{$C\alpha$ map, $T=0.6\epsilon$}
\label{subsec:no-knot-trmd-cb}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd-no-knot_cb_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.5312$
        \item $k_{prot}=0.0206$
        \item states = 4 (72.5, 80.6, 87.9, 90.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd-no-knot_cb_contour_lengths_1.png}
    \caption{All no-knot-TrmD experimental traces ($C\alpha$ map, $T=0.6\epsilon$).}
    \label{fig:no-knot-trmd-cb-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of no-knot-TrmD fitting in simulations ($C\alpha$ map, $T=0.6\epsilon$)}
    \label{tab:no-knot-trmd-cb-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.541 & 0.021 & 24.0, 26.7, 30.4, 34.6, 41.5, 47.3, 51.3, 54.0, 57.2, 60.8, 62.8, 64.4, 65.6, 69.5, 75.0, 77.8, 80.0, 84.5, 90.9\\
        2 & 0.480 & 0.020 & 15.2, 21.2, 28.2, 33.3, 35.7, 36.9, 39.0, 42.1, 44.3, 46.8, 50.1, 53.0, 56.9, 64.5, 70.3, 75.0, 78.8, 86.6, 90.4\\
        3 & 0.540 & 0.021 & 22.1, 24.1, 25.9, 28.0, 31.6, 36.6, 40.3, 42.4, 44.8, 47.2, 49.0, 51.3, 53.9, 56.9, 61.7, 70.9, 77.3, 79.9, 82.3, 87.4, 91.0, 97.4\\
        4 & 0.577 & 0.022 & 17.5, 23.4, 26.5, 30.9, 35.2, 47.5, 51.8, 55.4, 61.6, 65.8, 68.6, 76.2, 76.8, 82.1, 88.1, 91.0\\
        5 & 0.517 & 0.020 & 28.5, 30.9, 34.9, 39.6, 43.8, 48.9, 53.3, 57.1, 60.0, 68.3, 70.0, 72.1, 74.1, 76.7, 79.4, 81.3, 84.0, 88.8, 91.0\\
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.4\epsilon$}
\label{subsec:no-knot-trmd-pc}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd-no-knot_pc_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.2542$
        \item $k_{prot}=0.0172$
        \item states = 9 (7.6, 23.6, 35.9, 47.5, 64.1, 69.0, 71.3, 77.4, 90.6 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd-no-knot_pc_contour_lengths_1.png}
    \caption{All no-knot-TrmD experimental traces (Tsai map, $T=0.4\epsilon$).}
    \label{fig:no-knot-trmd-pc-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of no-knot-TrmD fitting in simulations (Tsai map, $T=0.4\epsilon$)}
    \label{tab:no-knot-trmd-pc-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.398 & 0.034 & 8.5, 25.1, 37.9, 50.1, 66.3, 72.5, 86.3, 90.8\\
        2 & 0.179 & 0.009 & 7.3, 17.7, 22.1, 25.0, 27.5, 33.6, 36.3, 46.8, 63.7, 72.9, 77.1, 88.6, 90.9\\
        3 & 0.309 & 0.023 & 7.5, 8.7, 16.2, 22.7, 26.7, 34.7, 37.1, 47.5, 63.5, 67.8, 73.1, 78.4, 90.8\\
        4 & 0.179 & 0.009 & 7.3, 22.9, 32.8, 35.0, 36.9, 39.0, 46.9, 60.3, 62.5, 63.7, 65.2, 67.7, 73.7, 77.1, 90.6\\
        5 & 0.205 & 0.011 & 7.3, 22.6, 34.4, 45.4, 59.2, 60.9, 62.3, 65.4, 68.3, 71.0, 74.5, 86.8, 90.5\\
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.5\epsilon$}
\label{subsec:no-knot-trmd-pa}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd-no-knot_pa_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.3306$
        \item $k_{prot}=0.0123$
        \item states = 10 (8.3, 21.9, 33.3, 44.0, 50.0, 73.5, 81.4, 86.4, 89.2, 91.0 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd-no-knot_pa_contour_lengths_1.png}
    \caption{All no-knot-TrmD experimental traces (Tsai map, $T=0.5\epsilon$).}
    \label{fig:no-knot-trmd-pa-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of no-knot-TrmD fitting in simulations (Tsai map, $T=0.5\epsilon$)}
    \label{tab:no-knot-trmd-pa-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.306 & 0.012 & 7.9, 14.5, 21.2, 22.9, 31.0, 36.9, 41.0, 48.3, 50.7, 81.7, 88.8, 90.9\\
        2 & 0.325 & 0.013 & 8.5, 22.0, 33.1, 44.4, 60.5, 69.6, 72.6, 81.8, 88.9, 91.0\\
        3 & 0.365 & 0.015 & 8.6, 21.4, 23.5, 33.8, 44.1, 51.8, 67.3, 70.0, 72.1, 74.9, 77.5, 81.0, 87.7, 91.0\\
        4 & 0.328 & 0.013 & 8.1, 16.3, 22.3, 32.5, 42.1, 44.3, 57.0, 62.7, 66.8, 70.6, 75.6, 84.5, 89.3, 91.0\\
        5 & 0.329 & 0.008 & 8.0, 9.7, 22.0, 33.6, 41.5, 47.5, 49.8, 68.2, 75.1, 79.6, 85.0, 89.7, 91.4\\
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.6\epsilon$}
\label{subsec:no-knot-trmd-pb}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd-no-knot_pb_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.5624$
        \item $k_{prot}=0.0224$
        \item states = 8 (21.9, 34.1, 42.6, 74.4, 82.0, 86.8, 89.2, 90.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd-no-knot_pb_contour_lengths_1.png}
    \caption{All no-knot-TrmD experimental traces (Tsai map, $T=0.6\epsilon$).}
    \label{fig:no-knot-trmd-pb-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of no-knot-TrmD fitting in simulations (Tsai map, $T=0.6\epsilon$)}
    \label{tab:no-knot-trmd-pb-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.616 & 0.025 & 12.4, 15.9, 19.4, 22.3, 24.5, 26.6, 29.4, 31.9, 34.0, 35.9, 38.2, 41.5, 43.4, 46.2, 49.4, 52.0, 55.3, 58.7, 61.8, 69.2, 75.6, 79.1, 85.9, 90.9\\
        2 & 0.587 & 0.024 & 11.4, 13.3, 15.0, 17.3, 21.7, 26.1, 29.5, 32.6, 35.3, 43.7, 46.7, 49.8, 54.9, 62.3, 72.2, 73.5, 74.7, 76.7, 78.1, 81.7, 84.9, 88.6, 91.1\\
        3 & 0.646 & 0.028 & 9.6, 12.1, 14.3, 17.9, 20.6, 22.7, 24.9, 27.2, 31.9, 35.9, 37.2, 46.9, 50.6, 53.5, 60.1, 69.2, 74.6, 76.5, 78.6, 80.9, 83.2, 86.2, 91.0\\
        4 & 0.376 & 0.012 & 9.7, 12.1, 14.3, 17.7, 20.9, 27.9, 30.6, 31.5, 48.3, 58.9, 59.9, 63.0, 66.3, 69.6, 72.5, 75.7, 82.5, 88.1, 90.4\\
        5 & 0.587 & 0.023 & 10.2, 13.7, 16.6, 20.2, 25.0, 30.7, 35.5, 36.9, 37.9, 42.2, 42.8, 62.9, 69.2, 71.8, 75.4, 81.3, 84.2, 87.6, 90.9\\
    \end{tabular}
\end{table}

\subsection{SMOG map, $T=0.4\epsilon$}
\label{subsec:no-knot-trmd-sc}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd-no-knot_sc_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=1.7853$
        \item $k_{prot}=0.0266$
        \item states = 3 (6.4, 68.7, 90.8 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd-no-knot_sc_contour_lengths_1.png}
    \caption{All no-knot-TrmD experimental traces (SMOG map, $T=0.4\epsilon$).}
    \label{fig:no-knot-trmd-sc-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of no-knot-TrmD fitting in simulations (SMOG map, $T=0.4\epsilon$)}
    \label{tab:no-knot-trmd-sc-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.223 & 0.014 & 6.1, 13.8, 29.4, 32.9, 35.8, 44.7, 57.2, 68.7, 90.9\\
        2 & 0.208 & 0.014 & 6.0, 7.0, 14.2, 29.4, 32.1, 35.6, 44.6, 57.3, 68.7, 90.7\\
        3 & 3.874 & 0.100 & 15.5, 20.3, 24.0, 31.4, 37.3, 55.7, 58.4, 61.8, 67.2, 72.9, 74.7, 89.8, 92.7\\
        4 & 0.589 & 0.005 & 0.0, 7.3, 16.3, 35.6, 39.6, 49.4, 63.7\\
        5 & 4.032 & 0.000 & 16.0, 20.2, 24.4, 29.5, 34.9, 37.4, 39.3, 42.7, 49.2, 51.3, 61.9, 65.5, 68.2, 70.7, 74.0, 77.9, 80.3, 82.7, 87.3, 92.5\\
    \end{tabular}
\end{table}

\subsection{SMOG map, $T=0.5\epsilon$}
\label{subsec:no-knot-trmd-sa}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd-no-knot_sa_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.2968$
        \item $k_{prot}=0.0122$
        \item states = 3 (6.6, 51.8, 90.6 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd-no-knot_sa_contour_lengths_1.png}
    \caption{All no-knot-TrmD experimental traces (SMOG map, $T=0.5\epsilon$).}
    \label{fig:no-knot-trmd-sa-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of no-knot-TrmD fitting in simulations (SMOG map, $T=0.5\epsilon$)}
    \label{tab:no-knot-trmd-sa-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.260 & 0.009 & 4.7, 9.7, 19.7, 25.0, 28.5, 35.7, 41.6, 73.4\\
        2 & 0.269 & 0.009 & 6.5, 12.0, 27.9, 30.8, 34.8, 43.9, 56.5, 67.4, 90.5\\
        3 & 0.269 & 0.010 & 6.4, 7.4, 12.5, 23.8, 30.4, 35.3, 43.8, 55.8, 67.2, 90.5\\
        4 & 0.270 & 0.009 & 6.7, 12.9, 25.0, 30.4, 34.9, 43.9, 66.0, 67.8, 88.3, 90.9\\
        5 & 0.416 & 0.023 & 7.0, 12.9, 24.5, 31.0, 44.6, 56.9, 68.4, 73.5, 90.7\\
    \end{tabular}
\end{table}

\subsection{SMOGmap, $T=0.6\epsilon$}
\label{subsec:no-knot-trmd-sb}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{trmd-no-knot_sb_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.4275$
        \item $k_{prot}=0.0140$
        \item states = 3 (42.3, 51.8, 90.7 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{trmd-no-knot_sb_contour_lengths_1.png}
    \caption{All no-knot-TrmD experimental traces (SMOG map, $T=0.6\epsilon$).}
    \label{fig:no-knot-trmd-sb-cl1}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of no-knot-TrmD fitting in simulations (SMOG map, $T=0.6\epsilon$)}
    \label{tab:no-knot-trmd-sb-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.330 & 0.007 & 7.2, 11.3, 22.8, 28.2, 32.4, 45.7, 51.7, 90.6\\
        2 & 0.466 & 0.016 & 8.1, 12.0, 23.5, 27.2, 30.2, 42.8, 61.7, 64.3, 80.9, 85.3, 88.4, 90.9\\
        3 & 0.447 & 0.015 & 7.6, 12.0, 26.5, 40.4, 43.7, 64.3, 86.6, 90.9\\
        4 & 0.442 & 0.015 & 7.7, 11.6, 21.1, 28.0, 41.9, 63.9, 90.7\\
        5 & 0.453 & 0.016 & 9.2, 26.8, 42.6, 62.1, 65.5, 87.3, 90.7\\
    \end{tabular}
\end{table}

\section{Analysis of 5wyr structure of TrmD in silico}
\label{sec:fit-details-5wyr-theory}
\subsection{$C\alpha$ map, $T=0.4\epsilon$}
\label{subsec:5wyr-cc}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{5wyr_cc_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.3025$
        \item $k_{prot}=0.0058$
        \item states = 5 (35.2, 58.0, 67.2, 81.3, 93.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_cc_contour_lengths_1.png}
    \caption{All 5wyr TrmD experimental traces ($C\alpha$ map, $T=0.4\epsilon$).}
    \label{fig:5wyr-cc-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_cc_contour_lengths_2.png}
    \caption{All 5wyr TrmD experimental traces ($C\alpha$ map, $T=0.4\epsilon$).}
    \label{fig:5wyr-cc-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of 5wyr TrmD fitting in simulations ($C\alpha$ map, $T=0.4\epsilon$)}
    \label{tab:5wyr-cc-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.299 & 0.005 & 10.5, 30.2, 34.1, 38.6, 54.3, 59.1, 64.9, 67.6, 81.4, 93.9\\
        2 & 0.315 & 0.006 & 11.7, 15.7, 19.2, 24.2, 30.9, 35.9, 42.9, 53.9, 63.4, 67.6, 81.4, 93.9\\
        3 & 0.313 & 0.006 & 21.8, 31.5, 37.8, 48.8, 54.8, 58.2, 63.4, 67.6, 77.9, 81.5, 93.9\\
        4 & 0.312 & 0.006 & 21.1, 31.6, 32.0, 35.2, 36.8, 38.9, 44.5, 53.9, 57.4, 62.5, 67.5, 81.1, 93.9\\
        5 & 0.309 & 0.006 & 21.9, 36.9, 54.4, 59.6, 66.8, 75.0, 81.5, 93.9\\
        6 & 0.311 & 0.006 & 14.1, 17.0, 20.4, 29.9, 33.6, 38.8, 57.5, 66.6, 74.5, 81.2, 93.9\\
        7 & 0.245 & 0.007 & 13.5, 26.2, 26.4, 30.9, 36.3, 39.3, 54.6, 62.7, 66.1, 79.0, 80.4, 92.6\\
        8 & 0.313 & 0.006 & 31.7, 34.7, 37.0, 38.6, 40.7, 55.2, 58.8, 64.9, 67.7, 79.5, 81.5, 93.9\\
        9 & 0.311 & 0.006 & 15.5, 19.3, 27.3, 33.9, 36.6, 38.9, 57.7, 62.9, 67.2, 70.1, 81.2, 93.9\\
        10 & 0.306 & 0.005 & 20.3, 30.5, 34.2, 38.9, 53.4, 56.7, 59.5, 63.7, 67.3, 79.6, 81.5, 93.9\\
        11 & 0.297 & 0.005 & 13.3, 19.7, 23.1, 27.7, 31.7, 34.2, 36.7, 55.2, 63.9, 66.5, 67.9, 81.6, 93.9\\
        12 & 0.301 & 0.005 & 10.8, 13.7, 16.5, 19.4, 27.4, 33.9, 37.8, 51.7, 54.1, 56.2, 58.2, 60.5, 64.7, 67.6, 80.1, 81.5, 93.9\\
        13 & 0.299 & 0.005 & 27.6, 30.6, 32.8, 53.1, 59.9, 64.6, 67.6, 81.3, 92.3, 93.9\\
        14 & 0.305 & 0.006 & 31.6, 33.1, 34.5, 36.0, 48.2, 52.7, 56.1, 59.9, 65.0, 67.9, 81.3, 93.9\\
        15 & 0.303 & 0.006 & 16.3, 22.2, 31.2, 34.5, 38.9, 52.9, 56.7, 61.6, 65.4, 67.2, 68.7, 81.1, 93.9\\
    \end{tabular}
\end{table}

\subsection{$C\alpha$ map, $T=0.5\epsilon$}
\label{subsec:5wyr-ca}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{5wyr_ca_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.4581$
        \item $k_{prot}=0.0078$
        \item states = 5 (35.7, 54.1, 58.2, 73.3, 93.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_ca_contour_lengths_1.png}
    \caption{All 5wyr TrmD experimental traces ($C\alpha$ map, $T=0.5\epsilon$).}
    \label{fig:5wyr-ca-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_ca_contour_lengths_2.png}
    \caption{All 5wyr TrmD experimental traces ($C\alpha$ map, $T=0.5\epsilon$).}
    \label{fig:5wyr-ca-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of 5wyr TrmD fitting in simulations ($C\alpha$ map, $T=0.5\epsilon$)}
    \label{tab:5wyr-ca-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.465 & 0.008 & 26.4, 30.8, 36.3, 53.2, 56.3, 68.1, 73.1, 76.9, 90.7, 94.0\\
        2 & 0.447 & 0.007 & 24.2, 29.1, 31.2, 34.6, 40.4, 46.4, 52.0, 55.5, 58.4, 62.3, 72.7, 77.4, 93.9\\
        3 & 0.453 & 0.008 & 22.3, 30.0, 33.2, 36.9, 44.6, 54.6, 58.5, 71.3, 73.7, 76.8, 93.9\\
        4 & 0.457 & 0.008 & 26.2, 36.1, 55.2, 70.2, 76.2, 93.9\\
        5 & 0.443 & 0.007 & 16.5, 22.0, 25.8, 35.2, 56.1, 59.0, 62.7, 76.5, 90.9, 93.9\\
        6 & 0.462 & 0.008 & 19.7, 24.8, 30.8, 35.1, 38.6, 42.9, 47.3, 53.8, 56.6, 59.4, 71.1, 76.1, 93.9\\
        7 & 0.457 & 0.008 & 29.6, 33.2, 35.9, 40.1, 42.9, 44.9, 49.1, 51.4, 53.4, 55.1, 58.1, 72.9, 90.6, 93.9\\
        8 & 0.465 & 0.008 & 31.1, 36.3, 44.8, 52.8, 53.0, 54.4, 58.8, 70.0, 72.9, 76.0, 93.9\\
        9 & 0.488 & 0.009 & 23.7, 28.3, 34.9, 40.9, 46.6, 52.3, 57.0, 66.6, 68.9, 70.9, 72.6, 73.0, 74.3, 93.9\\
        10 & 0.466 & 0.008 & 28.1, 30.9, 32.2, 36.8, 44.1, 54.1, 55.0, 58.6, 68.2, 71.0, 72.7, 91.3, 94.0\\
        11 & 0.462 & 0.008 & 28.5, 34.0, 37.2, 38.7, 54.0, 56.8, 63.0, 66.3, 69.3, 72.6, 90.4, 94.0\\
        12 & 0.472 & 0.009 & 21.5, 23.5, 25.9, 29.3, 31.3, 33.0, 34.8, 37.7, 41.6, 43.4, 48.1, 53.8, 56.6, 58.2, 59.7, 61.5, 75.0, 82.9, 93.9\\
        13 & 0.444 & 0.007 & 22.3, 27.9, 30.3, 31.9, 34.5, 40.0, 45.0, 47.8, 50.7, 56.4, 60.9, 69.1, 73.6, 90.0, 93.9\\
        14 & 0.460 & 0.008 & 25.1, 29.6, 34.0, 37.8, 41.2, 50.3, 55.3, 55.6, 59.3, 70.8, 75.5, 91.1, 94.0\\
        15 & 0.432 & 0.007 & 19.6, 21.5, 24.4, 30.1, 36.2, 41.4, 44.0, 49.3, 53.9, 57.6, 72.0, 93.8\\
    \end{tabular}
\end{table}

\subsection{$C\alpha$ map, $T=0.6\epsilon$}
\label{subsec:5wyr-cb}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{5wyr_cb_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.5809$
        \item $k_{prot}=0.0088$
        \item states = 2 (67.2, 93.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_cb_contour_lengths_1.png}
    \caption{All 5wyr TrmD experimental traces ($C\alpha$ map, $T=0.6\epsilon$).}
    \label{fig:5wyr-cb-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_cc_contour_lengths_2.png}
    \caption{All 5wyr TrmD experimental traces ($C\alpha$ map, $T=0.6\epsilon$).}
    \label{fig:5wyr-cb-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of 5wyr TrmD fitting in simulations ($C\alpha$ map, $T=0.6\epsilon$)}
    \label{tab:5wyr-cb-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.586 & 0.008 & 25.0, 30.5, 33.7, 35.8, 37.9, 40.1, 41.8, 44.4, 48.2, 50.7, 53.3, 56.1, 59.4, 63.5, 66.5, 69.5, 79.7, 93.9\\
        2 & 0.609 & 0.009 & 24.5, 26.7, 29.5, 32.9, 36.1, 38.0, 40.2, 42.9, 46.6, 49.0, 51.5, 57.7, 65.5, 68.6, 71.4, 88.5, 94.0, 103.1\\
        3 & 0.593 & 0.009 & 54.0, 56.0, 58.9, 60.5, 64.9, 72.2, 75.3, 83.9, 90.4, 93.2, 94.0\\
        4 & 0.624 & 0.009 & 32.9, 42.2, 58.0, 63.4, 64.6, 69.9, 87.7, 92.8, 94.0\\
        5 & 0.576 & 0.008 & 32.1, 35.8, 39.2, 42.0, 45.3, 50.9, 59.2, 65.5, 70.2, 80.0, 81.9, 89.7, 93.9\\
        6 & 0.581 & 0.008 & 36.4, 42.9, 46.0, 48.1, 50.8, 54.6, 60.0, 69.1, 89.4, 93.9\\
        7 & 0.589 & 0.008 & 31.8, 34.4, 37.7, 40.6, 46.6, 52.0, 56.0, 66.4, 69.8, 72.3, 80.4, 81.1, 90.0, 93.9\\
        8 & 0.613 & 0.009 & 42.3, 44.8, 46.8, 52.2, 56.1, 58.4, 60.1, 62.1, 64.8, 69.6, 85.2, 92.3, 94.0\\
        9 & 0.583 & 0.008 & 24.8, 29.2, 34.0, 37.2, 39.4, 43.6, 48.3, 51.7, 63.0, 63.0, 66.8, 70.0, 71.8, 72.4, 86.2, 92.3, 93.9\\
        10 & 0.578 & 0.008 & 31.1, 34.4, 37.2, 39.1, 41.1, 45.4, 48.4, 50.3, 52.1, 58.2, 62.2, 67.4, 71.4, 86.8, 92.5, 94.0\\
        11 & 0.428 & 0.013 & 23.2, 30.2, 33.5, 35.8, 39.4, 46.4, 46.6, 49.4, 53.1, 57.5, 61.9, 66.4, 69.7, 84.1, 92.0, 94.0\\
        12 & 0.583 & 0.008 & 24.2, 29.0, 35.7, 41.9, 45.4, 49.1, 56.1, 63.7, 67.8, 71.8, 89.1, 93.9\\
        13 & 0.608 & 0.009 & 32.4, 36.5, 41.2, 43.7, 46.4, 49.1, 51.4, 53.4, 56.2, 59.8, 62.8, 68.7, 69.2, 84.9, 92.0, 94.0\\
        14 & 0.587 & 0.008 & 26.3, 29.1, 31.4, 35.1, 46.8, 53.9, 66.4, 68.4, 72.2, 87.6, 92.5, 94.0\\
        15 & 0.576 & 0.008 & 30.8, 37.6, 40.2, 42.9, 45.7, 48.3, 49.9, 53.4, 60.8, 63.6, 68.5, 83.3, 91.5, 93.9\\
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.4\epsilon$}
\label{subsec:5wyr-pc}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{5wyr_pc_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.3745$
        \item $k_{prot}=0.0043$
        \item states = 9 (8.1, 11.0, 27.6, 33.5, 47.9, 68.1, 76.4, 81.4, 93.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_pc_contour_lengths_1.png}
    \caption{All 5wyr TrmD experimental traces (Tsai map, $T=0.4\epsilon$).}
    \label{fig:5wyr-pc-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_pc_contour_lengths_2.png}
    \caption{All 5wyr TrmD experimental traces (Tsai map, $T=0.4\epsilon$).}
    \label{fig:5wyr-pc-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of 5wyr TrmD fitting in simulations (Tsai map, $T=0.4\epsilon$)}
    \label{tab:5wyr-pc-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.383 & 0.004 & 8.0, 10.4, 14.1, 27.8, 34.4, 48.1, 68.2, 76.5, 81.6, 93.9\\
        2 & 0.377 & 0.004 & 8.2, 12.2, 28.1, 31.1, 33.6, 44.3, 48.3, 67.8, 76.5, 81.4, 93.9\\
        3 & 0.367 & 0.004 & 8.0, 10.7, 13.7, 26.9, 30.7, 34.1, 46.7, 64.9, 68.3, 76.2, 81.3, 93.8\\
        4 & 0.371 & 0.004 & 8.0, 10.5, 14.2, 27.5, 33.2, 37.5, 47.5, 67.6, 76.5, 81.3, 93.8\\
        5 & 0.325 & 0.006 & 7.9, 10.7, 26.1, 28.0, 29.4, 31.5, 34.0, 46.8, 66.4, 75.1, 79.3, 93.9\\
        6 & 0.387 & 0.004 & 8.0, 10.5, 14.3, 27.6, 33.5, 35.7, 37.7, 48.1, 67.9, 80.7, 90.9, 93.9\\
        7 & 0.375 & 0.004 & 8.2, 11.5, 26.5, 31.7, 36.7, 48.0, 68.0, 76.6, 81.5, 93.9\\
        8 & 0.377 & 0.004 & 8.3, 12.7, 27.9, 30.0, 32.3, 34.9, 37.5, 47.9, 68.0, 76.4, 81.4, 93.9\\
        9 & 0.391 & 0.005 & 8.0, 10.5, 13.8, 25.1, 28.5, 32.0, 37.2, 48.3, 68.5, 76.6, 81.0, 93.9\\
        10 & 0.379 & 0.004 & 8.4, 11.6, 28.3, 32.0, 34.1, 37.4, 47.5, 66.9, 76.2, 81.4, 93.9\\
        11 & 0.382 & 0.004 & 8.2, 11.7, 27.2, 29.7, 31.0, 32.7, 36.4, 45.2, 48.6, 68.1, 81.0, 93.9\\
        12 & 0.374 & 0.004 & 8.0, 10.5, 13.8, 25.2, 31.1, 34.0, 36.6, 47.0, 64.8, 68.6, 76.4, 81.4, 93.9\\
        13 & 0.374 & 0.004 & 8.0, 10.6, 14.0, 27.6, 30.8, 33.7, 37.5, 47.5, 67.5, 76.6, 88.3, 93.9\\
        14 & 0.381 & 0.004 & 8.2, 11.0, 27.9, 33.5, 37.1, 45.6, 48.1, 64.5, 68.5, 76.3, 81.5, 93.9\\
        15 & 0.375 & 0.004 & 8.8, 13.7, 27.3, 30.0, 33.1, 38.3, 47.9, 67.3, 76.2, 81.4, 93.9\\
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.5\epsilon$}
\label{subsec:5wyr-pa}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{5wyr_pa_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.4938$
        \item $k_{prot}=0.0069$
        \item states = 7 (9.5, 26.3, 31.3, 41.5, 59.8, 74.1, 93.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_pa_contour_lengths_1.png}
    \caption{All 5wyr TrmD experimental traces (Tsai map, $T=0.5\epsilon$).}
    \label{fig:5wyr-pa-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_pa_contour_lengths_2.png}
    \caption{All 5wyr TrmD experimental traces (Tsai map, $T=0.5\epsilon$).}
    \label{fig:5wyr-pa-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of 5wyr TrmD fitting in simulations (Tsai map, $T=0.5\epsilon$)}
    \label{tab:5wyr-pa-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.459 & 0.008 & 9.4, 25.2, 29.8, 32.6, 41.6, 55.0, 67.7, 74.6, 76.6, 90.0, 93.9\\
        2 & 0.457 & 0.008 & 9.5, 24.9, 28.6, 32.4, 40.6, 54.3, 65.2, 68.6, 70.5, 73.1, 87.4, 93.9\\
        3 & 0.463 & 0.008 & 8.9, 10.9, 24.4, 27.2, 29.0, 32.0, 40.1, 43.6, 58.0, 61.2, 73.9, 93.9\\
        4 & 0.527 & 0.006 & 10.0, 19.0, 26.5, 28.6, 31.7, 40.1, 44.1, 59.6, 69.6, 71.6, 72.9, 74.6, 77.3, 93.9\\
        5 & 0.529 & 0.006 & 9.4, 19.3, 26.1, 31.9, 41.3, 55.2, 71.2, 71.7, 75.5, 78.5, 93.9\\
        6 & 0.457 & 0.008 & 8.9, 10.2, 18.4, 23.3, 26.9, 28.1, 31.5, 41.0, 59.6, 71.1, 76.2, 93.9\\
        7 & 0.533 & 0.006 & 9.8, 17.4, 25.8, 31.1, 33.6, 42.8, 61.8, 75.8, 91.2, 93.9\\
        8 & 0.545 & 0.006 & 9.7, 12.3, 26.8, 32.3, 41.0, 44.0, 60.7, 64.9, 76.6, 79.7, 92.4, 93.9\\
        9 & 0.553 & 0.007 & 9.1, 10.4, 12.7, 25.6, 27.4, 32.1, 41.0, 45.2, 61.9, 73.1, 78.0, 91.8, 94.0\\
        10 & 0.465 & 0.008 & 9.4, 11.8, 22.8, 26.8, 31.2, 41.5, 58.0, 61.5, 63.6, 71.6, 87.8, 92.2, 94.0\\
        11 & 0.537 & 0.006 & 9.6, 11.9, 26.7, 32.5, 39.7, 43.4, 59.1, 73.0, 76.0, 78.3, 91.9, 94.0\\
        12 & 0.446 & 0.007 & 9.2, 25.9, 30.4, 31.8, 40.7, 56.6, 67.4, 70.5, 75.1, 93.9\\
        13 & 0.442 & 0.007 & 8.5, 9.8, 15.1, 25.4, 31.6, 39.9, 43.7, 59.2, 73.8, 93.8\\
        14 & 0.552 & 0.007 & 9.4, 13.9, 18.8, 25.8, 28.3, 29.7, 32.4, 41.2, 57.7, 67.9, 71.9, 74.8, 77.3, 85.6, 93.9\\
        15 & 0.443 & 0.007 & 9.3, 11.9, 23.7, 25.5, 31.0, 41.1, 55.6, 58.6, 68.0, 71.2, 73.8, 90.7, 93.9\\
    \end{tabular}
\end{table}

\subsection{Tsai map, $T=0.6\epsilon$}
\label{subsec:5wyr-pb}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{5wyr_pb_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.6131$
        \item $k_{prot}=0.0088$
        \item states = 4 (26.4, 38.0, 67.3, 93.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_pb_contour_lengths_1.png}
    \caption{All 5wyr TrmD experimental traces (Tsai map, $T=0.6\epsilon$).}
    \label{fig:5wyr-pb-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_pb_contour_lengths_2.png}
    \caption{All 5wyr TrmD experimental traces (Tsai map, $T=0.6\epsilon$).}
    \label{fig:5wyr-pb-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of 5wyr TrmD fitting in simulations (Tsai map, $T=0.6\epsilon$)}
    \label{tab:5wyr-pb-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.590 & 0.008 & 9.6, 11.8, 17.4, 25.1, 26.2, 32.4, 35.2, 38.5, 55.4, 64.2, 66.6, 69.6, 77.0, 83.7, 88.7, 93.0, 94.0\\
        2 & 0.575 & 0.008 & 10.4, 14.0, 18.2, 21.8, 25.8, 31.2, 37.0, 50.0, 51.7, 66.4, 67.7, 86.9, 91.6, 94.0\\
        3 & 0.578 & 0.008 & 10.8, 13.9, 16.4, 21.1, 24.4, 26.3, 28.6, 36.5, 37.7, 39.0, 53.0, 57.7, 62.2, 68.4, 89.0, 93.9\\
        4 & 0.623 & 0.009 & 11.2, 14.9, 16.9, 20.0, 24.7, 27.8, 30.0, 36.1, 39.2, 42.5, 66.3, 67.6, 70.5, 90.1, 94.0\\
        5 & 0.633 & 0.010 & 11.0, 16.3, 24.4, 28.4, 38.1, 41.6, 66.6, 67.2, 69.9, 72.3, 77.6, 80.2, 83.0, 88.8, 93.8, 94.0\\
        6 & 0.607 & 0.009 & 9.8, 12.3, 17.8, 26.2, 30.1, 32.0, 33.8, 35.5, 37.5, 41.7, 46.9, 49.8, 59.7, 62.8, 67.8, 72.8, 85.5, 91.7, 94.0\\
        7 & 0.595 & 0.009 & 11.6, 16.7, 18.8, 21.0, 24.0, 26.2, 28.7, 32.8, 38.5, 59.5, 63.4, 67.0, 69.8, 88.8, 94.0\\
        8 & 0.636 & 0.010 & 10.9, 20.0, 26.6, 27.8, 30.7, 31.7, 37.7, 46.4, 53.2, 65.1, 65.1, 67.4, 71.2, 75.9, 84.5, 91.7, 94.0\\
        9 & 0.625 & 0.010 & 11.1, 18.0, 29.0, 30.8, 38.6, 42.6, 56.0, 59.7, 66.5, 69.3, 72.4, 77.9, 88.8, 93.9\\
        10 & 0.584 & 0.008 & 11.2, 17.6, 26.6, 37.5, 38.5, 53.8, 54.5, 60.5, 65.7, 67.8, 70.3, 71.5, 76.0, 77.2, 88.3, 92.4, 94.0\\
        11 & 0.610 & 0.009 & 11.4, 18.1, 22.2, 26.1, 37.7, 37.9, 46.6, 49.4, 52.5, 54.7, 58.0, 61.1, 63.6, 68.6, 77.8, 80.2, 86.1, 92.6, 94.0\\
        12 & 0.697 & 0.008 & 12.2, 21.1, 26.7, 29.4, 31.6, 40.1, 48.0, 56.8, 68.1, 75.8, 78.2, 80.2, 83.6, 89.1, 93.9\\
        13 & 0.600 & 0.009 & 11.0, 14.3, 16.2, 23.9, 26.5, 27.3, 29.9, 37.2, 39.7, 56.7, 61.0, 62.9, 64.3, 66.4, 66.9, 68.8, 84.8, 88.6, 92.3, 94.0\\
        14 & 0.617 & 0.009 & 11.2, 16.2, 21.4, 23.9, 25.7, 28.8, 32.8, 38.5, 40.8, 50.8, 58.1, 66.9, 69.9, 78.1, 86.4, 92.1, 94.0\\
        15 & 0.627 & 0.010 & 10.6, 13.0, 15.9, 22.9, 24.6, 27.6, 30.6, 36.3, 38.8, 52.8, 58.2, 61.0, 64.5, 66.9, 70.4, 73.5, 75.1, 90.6, 94.0\\
    \end{tabular}
\end{table}

\subsection{SMOG map, $T=0.4\epsilon$}
\label{subsec:5wyr-sc}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{5wyr_sc_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.1961$
        \item $k_{prot}=0.0078$
        \item states = 3 (7.1, 48.5, 93.4 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_sc_contour_lengths_1.png}
    \caption{All 5wyr TrmD experimental traces (SMOG map, $T=0.4\epsilon$).}
    \label{fig:5wyr-sc-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_sc_contour_lengths_2.png}
    \caption{All 5wyr TrmD experimental traces (SMOG map, $T=0.4\epsilon$).}
    \label{fig:5wyr-sc-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of 5wyr TrmD fitting in simulations (SMOG map, $T=0.4\epsilon$)}
    \label{tab:5wyr-sc-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.337 & 0.004 & 7.7, 11.2, 15.5, 30.2, 35.3, 39.8, 48.9, 69.0, 81.0, 88.7, 93.4\\
        2 & 0.037 & 0.012 & 6.4, 10.1, 24.7, 29.1, 31.1, 35.5, 43.9, 55.9, 62.2, 73.3, 84.8\\
        3 & 0.049 & 0.012 & 6.4, 10.1, 25.7, 31.0, 35.6, 44.2, 56.6, 62.7, 73.8, 85.1\\
        4 & 0.354 & 0.003 & 7.8, 10.5, 11.9, 30.9, 35.6, 40.0, 49.0, 62.4, 69.4, 81.5, 89.1, 93.9\\
        5 & 0.262 & 0.005 & 7.5, 11.2, 29.6, 34.7, 39.0, 46.4, 48.0, 61.1, 67.8, 79.6, 87.0, 91.8\\
        6 & 0.011 & 0.014 & 6.1, 10.0, 27.3, 30.3, 34.5, 43.0, 54.9, 61.0, 71.8, 78.6, 83.0\\
        7 & 0.013 & 0.014 & 6.0, 9.7, 12.3, 26.0, 30.1, 34.3, 42.9, 55.1, 61.0, 71.8, 78.8, 83.1\\
        8 & 0.335 & 0.004 & 7.7, 10.6, 11.6, 30.3, 35.2, 39.8, 48.8, 62.0, 69.0, 81.0, 88.8, 93.5\\
        9 & 0.358 & 0.004 & 0.0, 7.8, 11.6, 30.7, 35.6, 39.7, 49.0, 62.6, 69.4, 81.5, 89.0, 93.9\\
        10 & 0.337 & 0.003 & 7.7, 10.4, 11.6, 29.5, 32.6, 34.1, 35.6, 39.7, 46.3, 48.9, 69.2, 81.2, 93.6\\
        11 & 0.232 & 0.006 & 7.3, 11.0, 28.4, 34.0, 38.6, 47.4, 60.2, 67.2, 78.9, 86.3, 91.0\\
        12 & 0.153 & 0.008 & 7.0, 10.9, 28.5, 33.0, 37.4, 46.2, 59.2, 65.6, 77.1, 90.0\\
        13 & 0.038 & 0.013 & 6.3, 10.1, 25.6, 30.7, 35.3, 43.9, 56.1, 62.2, 73.2, 80.2, 84.6\\
        14 & 0.141 & 0.009 & 7.0, 10.7, 27.3, 32.9, 37.2, 46.0, 58.7, 65.2, 76.8, 88.6\\
        15 & 0.285 & 0.005 & 7.5, 11.2, 31.3, 34.7, 39.2, 48.2, 61.6, 68.2, 80.1, 87.8, 92.3\\
    \end{tabular}
\end{table}

\subsection{SMOG map, $T=0.5\epsilon$}
\label{subsec:5wyr-sa}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{5wyr_sa_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.4525$
        \item $k_{prot}=0.0057$
        \item states = 3 (8.3, 48.5, 93.7 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_sa_contour_lengths_1.png}
    \caption{All 5wyr TrmD experimental traces (SMOG map, $T=0.5\epsilon$).}
    \label{fig:5wyr-sa-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_sa_contour_lengths_2.png}
    \caption{All 5wyr TrmD experimental traces (SMOG map, $T=0.5\epsilon$).}
    \label{fig:5wyr-sa-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of 5wyr TrmD fitting in simulations (SMOG map, $T=0.5\epsilon$)}
    \label{tab:5wyr-sa-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.428 & 0.006 & 8.1, 10.7, 15.9, 27.7, 33.7, 38.8, 48.1, 67.6, 80.0, 93.9\\
        2 & 0.488 & 0.005 & 8.2, 10.2, 14.7, 28.6, 34.4, 39.3, 49.0, 81.2, 93.9\\
        3 & 0.376 & 0.007 & 7.9, 10.3, 25.9, 28.4, 32.6, 38.4, 47.7, 78.9, 91.7\\
        4 & 0.492 & 0.005 & 8.3, 10.3, 28.9, 31.1, 34.9, 39.4, 49.0, 69.0, 81.2, 93.7, 93.9\\
        5 & 0.408 & 0.006 & 8.2, 25.8, 29.1, 33.1, 38.8, 48.1, 79.5, 93.9\\
        6 & 0.497 & 0.005 & 8.2, 9.9, 28.5, 34.9, 39.6, 49.1, 69.2, 81.4, 92.5, 93.9\\
        7 & 0.401 & 0.006 & 7.9, 10.0, 27.6, 33.7, 38.2, 47.7, 67.0, 79.6, 92.2\\
        8 & 0.420 & 0.006 & 8.0, 10.3, 26.9, 33.1, 38.8, 48.1, 67.8, 79.9, 87.8, 92.4\\
        9 & 0.490 & 0.005 & 8.2, 10.7, 14.7, 28.6, 34.8, 39.4, 48.8, 62.2, 79.8, 81.3, 93.9\\
        10 & 0.487 & 0.005 & 8.2, 10.7, 27.1, 30.2, 33.9, 39.4, 48.9, 68.8, 81.3, 93.9\\
        11 & 0.444 & 0.007 & 8.1, 10.2, 27.5, 29.7, 33.8, 39.0, 48.2, 61.4, 67.9, 80.2, 93.9\\
        12 & 0.497 & 0.005 & 8.6, 27.3, 29.9, 34.1, 39.6, 49.0, 68.6, 81.2, 93.9, 94.2\\
        13 & 0.435 & 0.007 & 8.1, 10.7, 27.1, 28.8, 34.3, 38.9, 48.1, 78.0, 80.0, 93.9\\
        14 & 0.470 & 0.005 & 8.2, 10.8, 15.2, 28.4, 34.1, 39.3, 48.8, 68.8, 80.8, 88.7, 93.5\\
        15 & 0.454 & 0.006 & 8.2, 11.2, 26.6, 29.5, 33.9, 38.7, 48.5, 61.9, 68.8, 80.6, 93.2\\
    \end{tabular}
\end{table}

\subsection{SMOG map, $T=0.6\epsilon$}
\label{subsec:5wyr-sb}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{5wyr_sb_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=0.6156$
        \item $k_{prot}=0.0058$
        \item states = 3 (47.9, 79.5, 93.8 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_sb_contour_lengths_1.png}
    \caption{All 5wyr TrmD experimental traces (SMOG map, $T=0.4\epsilon$).}
    \label{fig:5wyr-sb-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{5wyr_sb_contour_lengths_2.png}
    \caption{All 5wyr TrmD experimental traces (SMOG map, $T=0.4\epsilon$).}
    \label{fig:5wyr-sb-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{Parameters of 5wyr TrmD fitting in simulations (SMOG map, $T=0.4\epsilon$)}
    \label{tab:5wyr-sb-parameters}
    \begin{tabular}{c|c|c|c}
        \textbf{Trace} & \textbf{$p_{prot}$} & \textbf{$k_{prot}$} & \textbf{States [nm]}\\\hline
        1 & 0.583 & 0.004 & 9.5, 22.9, 26.4, 31.7, 37.7, 47.8, 66.8, 79.0, 93.7\\
        2 & 0.596 & 0.004 & 9.3, 21.2, 26.7, 29.5, 31.8, 34.5, 37.8, 48.1, 79.6, 93.3, 93.8\\
        3 & 0.588 & 0.004 & 9.5, 15.4, 28.3, 37.2, 47.4, 65.4, 79.2, 93.7\\
        4 & 0.548 & 0.007 & 8.9, 14.0, 26.4, 28.4, 30.5, 32.9, 36.3, 47.1, 76.1, 79.1, 93.9\\
        5 & 0.640 & 0.006 & 9.4, 16.3, 28.6, 31.9, 34.5, 37.9, 48.2, 67.0, 79.9, 86.5, 93.8\\
        6 & 0.587 & 0.004 & 9.4, 18.3, 26.3, 30.2, 37.3, 47.0, 65.1, 76.8, 78.9, 92.0, 93.9\\
        7 & 0.665 & 0.007 & 9.6, 12.0, 28.7, 31.4, 33.8, 37.6, 48.0, 80.0, 93.9\\
        8 & 0.571 & 0.008 & 9.3, 27.1, 28.9, 30.3, 33.4, 37.3, 47.4, 65.3, 78.1, 93.9\\
        9 & 0.671 & 0.007 & 9.5, 11.7, 18.0, 29.1, 37.7, 48.3, 75.6, 80.2, 93.1, 94.0\\
        10 & 0.640 & 0.006 & 9.7, 10.9, 27.5, 33.3, 37.6, 47.9, 79.9, 93.9\\
        11 & 0.648 & 0.006 & 9.0, 10.2, 12.7, 23.8, 27.3, 30.4, 32.4, 34.9, 37.6, 47.5, 65.3, 79.8, 93.9\\
        12 & 0.663 & 0.007 & 9.3, 11.0, 28.8, 31.8, 34.3, 38.1, 48.2, 78.2, 80.9, 93.9\\
        13 & 0.650 & 0.006 & 9.4, 10.9, 16.5, 28.2, 33.2, 38.2, 48.6, 80.1, 93.9\\
        14 & 0.587 & 0.004 & 9.2, 10.6, 25.0, 27.7, 30.3, 30.7, 32.2, 36.9, 38.7, 47.8, 66.5, 79.1, 93.8\\
        15 & 0.597 & 0.005 & 9.5, 19.8, 28.5, 36.1, 47.0, 78.8, 80.2, 93.8\\
    \end{tabular}
\end{table}

\section{Analysis of TrmD in experiment}
\label{sec:fit-details-trmd-experiment}
\subsection{Regular fit (result - unknotted)}
\label{subsec:fit-details-trmd-experiment-unknotted}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{results-experiment-trmd-histo.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=5.9360$
        \item $k_{prot}=0.0000$
        \item $p_{dna}=0.1591$
        \item $k_{dna}=0.0090$
        \item $l_{dna}=339.438$
        \item states = 3 (45.2, 51.9, 86.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{unknotted_trmd_exp_contour_lengths_1.png}
    \caption{All TrmD experimental traces.}
    \label{fig:unkotted-trmd-exp-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{unknotted_trmd_exp_contour_lengths_2.png}
    \caption{All TrmD experimental traces (continued).}
    \label{fig:unkotted-trmd-exp-cl2}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{unknotted_trmd_exp_contour_lengths_3.png}
    \caption{All TrmD experimental traces (continued).}
    \label{fig:unkotted-trmd-exp-cl3}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{unknotted_trmd_exp_contour_lengths_4.png}
    \caption{All TrmD experimental traces (continued).}
    \label{fig:unkotted-trmd-exp-cl4}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{The fit parameters for TrmD (experiment, assumed unknotted).}
    \label{tab:trmd-fit-parameters-exp-unknotted}
    \begin{tabular}{c|c|c|c|c}
        \textbf{Trace} & $p_{dna}$ & $l_{dna}$ & $l_{prot}$ & states [nm]\\\hline
        1 & 0.143 & 340.127 & 5.936 & 46.4, 53.2, 87.1\\
        2 & 0.210 & 342.254 & 5.936 & 43.6, 47.3, 51.7, 53.2, 87.1\\
        3 & 0.210 & 343.767 & 5.936 & 40.2, 43.4, 47.8, 85.1, 89.2\\
        4 & 0.210 & 345.437 & 5.936 & 39.8, 42.3, 50.5, 86.6\\
        5 & 0.191 & 344.764 & 5.936 & 34.0, 48.5, 53.0, 56.2, 87.1\\
        6 & 0.155 & 342.986 & 5.936 & 46.7, 53.7, 56.4, 87.1\\
        7 & 0.137 & 342.045 & 5.936 & 45.8, 54.7, 87.0\\
        8 & 0.156 & 343.190 & 5.936 & 45.0, 53.0, 87.0\\
        9 & 0.130 & 345.102 & 5.936 & 42.5, 51.5, 85.3\\
        10 & 0.210 & 345.664 & 5.936 & 43.1, 46.4, 51.2, 86.6\\
        11 & 0.210 & 345.620 & 5.936 & 49.7, 83.9\\
        12 & 0.168 & 343.993 & 5.936 & 38.4, 43.0, 48.7, 84.7\\
        13 & 0.150 & 342.776 & 5.936 & 45.3, 52.3, 86.8\\
        14 & 0.210 & 344.203 & 5.936 & 53.0, 87.0\\
        15 & 0.188 & 343.914 & 5.936 & 45.7, 52.4, 87.0\\
        16 & 0.169 & 344.101 & 5.936 & 43.3, 45.6, 51.8, 87.1\\
        17 & 0.161 & 345.726 & 5.936 & 41.4, 50.0, 83.9, 87.4\\
        18 & 0.130 & 342.381 & 5.936 & 45.0, 52.1, 86.9\\
        19 & 0.130 & 340.034 & 5.936 & 45.1, 52.0, 87.2\\
        20 & 0.160 & 338.727 & 5.936 & 47.8, 50.1, 52.2, 87.4\\
        21 & 0.159 & 338.527 & 5.936 & 43.7, 47.8, 52.4, 87.0\\
        22 & 0.163 & 337.772 & 5.936 & 52.8, 86.9\\
        23 & 0.130 & 337.142 & 5.936 & 45.3, 49.7, 52.5, 79.1, 87.7\\
        24 & 0.163 & 332.855 & 5.936 & 48.5, 88.3\\
        25 & 0.130 & 331.275 & 5.936 & 48.0, 56.4, 87.1\\
        26 & 0.161 & 335.616 & 5.936 & 18.7, 43.7, 46.8, 54.5, 84.7\\
        27 & 0.130 & 334.444 & 5.936 & 45.4, 48.4, 49.0, 87.4\\
        28 & 0.163 & 334.098 & 5.936 & 52.9, 87.2, 91.9\\
        29 & 0.130 & 335.503 & 5.936 & 50.1, 85.2, 90.7\\
        30 & 0.155 & 336.108 & 5.936 & 46.9, 53.2, 87.3\\
        31 & 0.160 & 336.153 & 5.936 & 40.8, 47.2, 50.8, 54.9, 87.6\\
        32 & 0.130 & 335.449 & 5.936 & 38.5, 52.0, 58.7, 87.3\\
        33 & 0.160 & 335.847 & 5.936 & 50.9, 53.5, 87.2\\
        34 & 0.130 & 335.473 & 5.936 & 47.2, 53.9, 87.3\\
        35 & 0.130 & 335.570 & 5.936 & 47.0, 53.8, 86.6\\
        36 & 0.162 & 335.398 & 5.936 & 54.8, 59.8, 85.5, 88.0\\
        37 & 0.130 & 334.586 & 5.936 & 47.7, 55.2, 86.8\\
        38 & 0.130 & 334.962 & 5.936 & 48.0, 56.8, 87.6\\
        39 & 0.162 & 334.493 & 5.936 & 55.6, 87.2\\
    \end{tabular}
\end{table}

\subsection{Assumed knotted state}
\label{subsec:fit-details-trmd-experiment-knotted}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{results-experiment-trmd-histo-knotted.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=5.9360$
        \item $k_{prot}=0.0000$
        \item $p_{dna}=0.1565$
        \item $k_{dna}=0.0090$
        \item $l_{dna}=342.374$
        \item states = 3 (40.3, 47.1, 81.9 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{knotted_trmd_exp_contour_lengths_1.png}
    \caption{All TrmD experimental traces assuming knotted protein.}
    \label{fig:knotted-trmd-exp-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{knotted_trmd_exp_contour_lengths_2.png}
    \caption{All TrmD experimental traces assuming knotted protein (continued).}
    \label{fig:knotted-trmd-exp-cl2}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{knotted_trmd_exp_contour_lengths_3.png}
    \caption{All TrmD experimental traces assuming knotted protein (continued).}
    \label{fig:knotted-trmd-exp-cl3}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{knotted_trmd_exp_contour_lengths_4.png}
    \caption{All TrmD experimental traces assuming knotted protein (continued).}
    \label{fig:knotted-trmd-exp-cl4}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{The fit parameters for TrmD (experiment, assumed knotted).}
    \label{tab:trmd-fit-parameters-exp-knotted}
    \begin{tabular}{c|c|c|c|c}
        \textbf{Trace} & $p_{dna}$ & $l_{dna}$ & $l_{prot}$ & states [nm]\\\hline
        1 & 0.143 & 340.127 & 82.125 & 46.4, 53.2, 87.1\\
        2 & 0.210 & 345.925 & 82.125 & 38.7, 42.0, 46.4, 82.0\\
        3 & 0.210 & 347.494 & 82.125 & 35.0, 38.3, 43.0, 79.9, 84.0\\
        4 & 0.210 & 349.143 & 82.125 & 34.3, 36.8, 45.3, 81.5\\
        5 & 0.195 & 348.582 & 82.125 & 42.6, 47.8, 50.8, 81.9\\
        6 & 0.163 & 346.929 & 82.125 & 40.9, 50.4, 52.2, 82.0\\
        7 & 0.144 & 345.992 & 82.125 & 40.3, 49.5, 81.8\\
        8 & 0.171 & 347.406 & 82.125 & 39.9, 47.9, 81.9\\
        9 & 0.130 & 347.434 & 82.125 & 38.9, 48.1, 82.1\\
        10 & 0.210 & 349.114 & 82.125 & 39.3, 46.5, 81.8\\
        11 & 0.210 & 347.435 & 82.125 & 47.0, 81.3\\
        12 & 0.168 & 327.750 & 82.125 & 62.0, 66.6, 69.1, 71.9, 75.1, 92.0, 106.6\\
        13 & 0.189 & 347.900 & 82.125 & 40.9, 44.3, 48.0, 81.8\\
        14 & 0.177 & 346.774 & 82.125 & 46.9, 81.9\\
        15 & 0.194 & 347.800 & 82.125 & 40.6, 46.7, 50.1, 81.9\\
        16 & 0.190 & 348.537 & 82.125 & 38.3, 40.6, 46.9, 82.0\\
        17 & 0.130 & 348.195 & 82.125 & 35.4, 44.9, 82.0\\
        18 & 0.130 & 346.037 & 82.125 & 39.5, 47.0, 81.8\\
        19 & 0.130 & 343.693 & 82.125 & 39.6, 46.9, 82.0\\
        20 & 0.130 & 341.196 & 82.125 & 42.6, 82.1\\
        21 & 0.169 & 342.572 & 82.125 & 38.6, 42.8, 47.4, 81.9\\
        22 & 0.210 & 343.058 & 82.125 & 48.6, 81.9\\
        23 & 0.130 & 340.845 & 82.125 & 40.0, 44.5, 47.4, 74.0, 82.5\\
        24 & 0.130 & 335.372 & 82.125 & 41.5, 82.9\\
        25 & 0.130 & 334.930 & 82.125 & 42.2, 51.2, 82.0\\
        26 & 0.130 & 338.177 & 82.125 & 27.5, 39.3, 48.2, 79.2\\
        27 & 0.130 & 337.881 & 82.125 & 30.4, 43.2, 82.5\\
        28 & 0.210 & 339.235 & 82.125 & 45.0, 49.4, 52.4, 82.0, 87.4\\
        29 & 0.130 & 339.217 & 82.125 & 44.2, 80.0, 85.4\\
        30 & 0.130 & 338.777 & 82.125 & 42.5, 48.1, 82.2\\
        31 & 0.130 & 338.788 & 82.125 & 30.4, 40.4, 43.6, 50.9, 82.2\\
        32 & 0.130 & 339.110 & 82.125 & 30.8, 46.0, 53.3, 82.2\\
        33 & 0.130 & 338.424 & 82.125 & 45.9, 50.8, 82.0\\
        34 & 0.130 & 339.139 & 82.125 & 41.9, 48.8, 82.2\\
        35 & 0.130 & 338.592 & 82.125 & 42.6, 82.3\\
        36 & 0.130 & 337.836 & 82.125 & 45.0, 49.1, 53.1, 80.5, 82.9\\
        37 & 0.130 & 337.934 & 82.125 & 42.4, 50.5, 82.1\\
        38 & 0.130 & 338.628 & 82.125 & 42.2, 51.5, 82.5\\
        39 & 0.130 & 336.930 & 82.125 & 45.6, 49.8, 82.1\\
    \end{tabular}
\end{table}

\section{Analysis of Tm1570 in experiment}
\label{sec:fit-details-tm1570-experiment}

\subsection{Assumed unknotted state}
\label{subsec:fit-details-tm1570-experiment-unknotted}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{tm1570_exp_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=5.9360$
        \item $k_{prot}=0.0000$
        \item $p_{dna}=0.1691$
        \item $k_{dna}=0.0090$
        \item $l_{dna}=333.878$
        \item states = 11 (10.5, 16.4, 20.3, 27.0, 33.5, 40.0, 44.2, 52.6, 57.7, 62.0, 69.2 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{tm1570_exp_contour_lengths_1.png}
    \caption{All Tm1570 experimental traces assuming unknotted protein.}
    \label{fig:unknotted-tm1570-exp-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{tm1570_exp_contour_lengths_2.png}
    \caption{All Tm1570 experimental traces assuming unknotted protein (continued).}
    \label{fig:unknotted-tm1570-exp-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{The fit parameters for Tm1570 (experiment, assumed unknotted).}
    \label{tab:tm1570-fit-parameters-exp-unknotted}
    \begin{tabular}{c|c|c|c|c}
        \textbf{Trace} & $p_{dna}$ & $l_{dna}$ & $l_{prot}$ & states [nm]\\\hline
        1 & 0.130 & 339.650 & 70.080 & 20.9, 27.8, 50.8, 59.5, 62.2, 68.1\\
        2 & 0.130 & 338.952 & 70.080 & 17.2, 24.0, 40.3, 44.4, 62.2, 69.3\\
        3 & 0.131 & 339.289 & 70.080 & 22.6, 26.4, 30.4, 40.6, 42.2, 44.1, 47.1, 51.0, 61.2, 69.4\\
        4 & 0.130 & 338.819 & 70.080 & 15.9, 18.8, 26.7, 40.2, 44.1, 57.5, 61.8, 69.3\\
        5 & 0.133 & 338.419 & 70.080 & 12.2, 20.6, 33.8, 49.6, 52.6, 57.3, 60.9, 69.2\\
        6 & 0.131 & 343.863 & 70.080 & 10.4, 15.4, 53.3, 69.7\\
        7 & 0.130 & 344.082 & 68.716 & 26.2, 32.2, 37.4, 43.4, 49.6, 52.8, 67.5\\
        8 & 0.132 & 343.189 & 70.080 & 16.2, 26.6, 53.4, 60.4, 67.6, 69.9\\
        9 & 0.199 & 345.120 & 70.080 & 19.8, 29.4, 53.7, 69.2\\
        10 & 0.141 & 343.094 & 70.080 & 28.2, 33.7, 43.5, 51.3, 60.9, 68.9\\
        11 & 0.210 & 344.156 & 69.958 & 29.6, 35.7, 37.7, 52.4, 63.0, 69.6\\
        12 & 0.130 & 336.336 & 70.080 & 23.3, 25.6, 29.5, 33.6, 39.3, 45.6, 69.9, 73.4, 75.9\\
        13 & 0.130 & 339.378 & 70.080 & 32.6, 41.1, 50.6, 64.8, 70.9\\
        14 & 0.131 & 335.895 & 70.080 & 33.7, 36.1, 36.6, 43.9, 48.4, 54.9, 70.0\\
    \end{tabular}
\end{table}

\subsection{Assumed knotted state}
\label{subsec:fit-details-tm1570-experiment-knotted}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{tm1570_kexp_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=5.9360$
        \item $k_{prot}=0.0000$
        \item $p_{dna}=0.1929$
        \item $k_{dna}=0.0090$
        \item $l_{dna}=345.998$
        \item states = 9 (16.9, 24.9, 29.6, 35.2, 39.9, 48.0, 57.1, 57.4, 64.3 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{tm1570_kexp_contour_lengths_1.png}
    \caption{All Tm1570 experimental traces assuming knotted protein.}
    \label{fig:knotted-tm1570-exp-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{tm1570_kexp_contour_lengths_2.png}
    \caption{All Tm1570 experimental traces assuming knotted protein (continued).}
    \label{fig:knotted-tm1570-exp-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{The fit parameters for Tm1570 (experiment, assumed knotted).}
    \label{tab:tm1570-fit-parameters-exp-knotted}
    \begin{tabular}{c|c|c|c|c}
        \textbf{Trace} & $p_{dna}$ & $l_{dna}$ & $l_{prot}$ & states [nm]\\\hline
        1 & 0.210 & 345.909 & 64.970 & 17.2, 24.0, 46.1, 56.4, 63.5\\
        2 & 0.210 & 345.235 & 64.970 & 13.8, 20.9, 29.6, 36.3, 40.0, 57.4, 64.3\\
        3 & 0.210 & 345.562 & 64.970 & 20.2, 26.5, 38.9, 46.5, 56.4, 64.3\\
        4 & 0.210 & 345.052 & 64.970 & 11.9, 14.5, 17.6, 27.2, 35.9, 39.8, 47.3, 52.8, 56.9, 64.3\\
        5 & 0.210 & 344.555 & 64.970 & 10.6, 16.7, 30.6, 45.6, 52.5, 56.2, 64.1\\
        6 & 0.210 & 350.207 & 64.970 & 6.1, 11.0, 17.5, 48.5, 64.6\\
        7 & 0.210 & 349.459 & 64.970 & 24.0, 27.4, 30.9, 34.5, 39.8, 46.3, 49.5, 64.0\\
        8 & 0.210 & 349.525 & 64.970 & 13.1, 17.4, 23.6, 40.8, 47.3, 49.5, 55.6, 64.0\\
        9 & 0.210 & 349.142 & 64.970 & 12.3, 15.8, 24.2, 48.6, 64.0\\
        10 & 0.210 & 349.077 & 64.970 & 24.1, 29.2, 36.2, 46.7, 51.6, 56.2, 63.9\\
        11 & 0.210 & 347.762 & 64.970 & 24.1, 29.9, 31.9, 47.2, 58.0, 64.6\\
        12 & 0.130 & 339.980 & 64.970 & 20.2, 25.4, 32.4, 34.0, 38.5, 64.8, 70.7\\
        13 & 0.130 & 343.075 & 64.970 & 26.3, 33.0, 37.1, 59.4, 65.7\\
        14 & 0.130 & 339.437 & 64.970 & 30.0, 36.9, 40.8, 42.8, 44.4, 49.7, 64.8\\
    \end{tabular}
\end{table}

\section{Analysis of fusion TrmD-Tm1570 in experiment}
\label{sec:fit-details-fusion-experiment}

\subsection{Assumed unknotted state}
\label{subsec:fit-details-fusion-experiment-unknotted}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{fuzja_exp_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=5.9360$
        \item $k_{prot}=0.0000$
        \item $p_{dna}=0.1724$
        \item $k_{dna}=0.0090$
        \item $l_{dna}=335.848$
        \item states = 12 (33.3, 41.2, 46.1, 56.5, 73.5, 88.6, 91.9, 96.9, 102.6, 125.5, 134.1, 138.1 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{fuzja_exp_contour_lengths_1.png}
    \caption{All fusion experimental traces assuming unknotted protein.}
    \label{fig:unknotted-fusion-exp-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{fuzja_exp_contour_lengths_2.png}
    \caption{All fusion experimental traces assuming unknotted protein (continued).}
    \label{fig:unknotted-fusion-exp-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{The fit parameters for fusion (experiment, assumed unknotted).}
    \label{tab:fusion-fit-parameters-exp-unknotted}
    \begin{tabular}{c|c|c|c|c}
        \textbf{Trace} & $p_{dna}$ & $l_{dna}$ & $l_{prot}$ & states [nm]\\\hline
        1 & 0.132 & 332.318 & 157.315 & 60.8, 72.1, 74.2, 87.5, 96.0, 97.6, 109.3, 133.8, 157.3\\
        2 & 0.210 & 340.781 & 157.315 & 59.1, 67.1, 82.4, 90.9, 94.7, 96.6, 125.2, 158.1, 177.0\\
        3 & 0.210 & 340.469 & 157.242 & 57.4, 62.4, 79.8, 89.7, 120.7, 127.0, 156.5, 158.1\\
        4 & 0.148 & 330.000 & 133.593 & 55.6, 72.8, 91.3, 134.3\\
        5 & 0.153 & 339.926 & 157.315 & 33.4, 37.4, 41.7, 53.9, 157.4\\
        6 & 0.141 & 339.726 & 157.315 & 26.5, 29.8, 33.0, 36.3, 40.6, 42.5, 87.9, 157.4\\
        7 & 0.210 & 337.714 & 157.250 & 41.4, 43.3, 49.7, 58.8, 95.9, 162.5\\
        8 & 0.166 & 338.961 & 157.315 & 29.1, 44.7, 54.3, 90.2\\
        9 & 0.130 & 337.210 & 157.315 & 27.1, 29.9, 32.9, 37.1, 41.0, 46.8, 56.2, 92.3, 157.6\\
        10 & 0.130 & 330.021 & 138.206 & 82.1, 82.7, 97.1, 103.8, 138.0\\
        11 & 0.144 & 331.173 & 128.726 & 47.6, 52.1, 93.5, 96.1, 103.9\\
        12 & 0.147 & 330.000 & 127.728 & 101.3, 110.8, 123.2, 125.8, 129.2\\
        13 & 0.210 & 330.954 & 129.087 & 104.2, 113.4, 126.5, 131.4\\
        14 & 0.210 & 338.259 & 156.753 & 90.5, 95.3, 100.8, 101.0, 149.7, 154.3, 159.1\\
        15 & 0.133 & 335.604 & 157.315 & 86.2, 99.2, 112.8, 116.0, 152.1, 154.8, 157.0, 159.2\\
        16 & 0.210 & 338.322 & 157.315 & 90.4, 95.6, 100.8, 112.5, 151.1, 152.7, 157.7\\
        17 & 0.210 & 337.113 & 157.267 & 92.2, 97.9, 101.5, 112.9, 150.5, 153.2, 157.5\\
        19 & 0.210 & 336.720 & 156.560 & 90.8, 99.1, 113.1, 151.1, 155.8, 158.0, 159.5\\
    \end{tabular}
\end{table}

\subsection{Assumed singly knotted state}
\label{subsec:fit-details-fusion-experiment-singly}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{fuzja_pexp_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=5.9360$
        \item $k_{prot}=0.0000$
        \item $p_{dna}=0.2011$
        \item $k_{dna}=0.0090$
        \item $l_{dna}=338.832$
        \item states = 11 (29.1, 36.2, 40.1, 85.9, 95.5, 108.2, 114.9, 128.2, 142.5, 146.4, 152.8 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{fuzja_pexp_contour_lengths_1.png}
    \caption{All fusion experimental traces assuming singly knotted protein.}
    \label{fig:unknotted-fusion-pexp-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{fuzja_pexp_contour_lengths_2.png}
    \caption{All fusion experimental traces assuming singly knotted protein (continued).}
    \label{fig:unknotted-fusion-pexp-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{The fit parameters for fusion (experiment, assumed singly knotted).}
    \label{tab:fusion-fit-parameters-pexp-unknotted}
    \begin{tabular}{c|c|c|c|c}
        \textbf{Trace} & $p_{dna}$ & $l_{dna}$ & $l_{prot}$ & states [nm]\\\hline
        1 & 0.130 & 335.909 & 152.205 & 55.3, 68.7, 82.0, 90.9, 92.2, 102.5, 105.0, 128.7, 152.2\\
        2 & 0.210 & 344.509 & 152.205 & 54.0, 59.0, 61.3, 76.6, 85.8, 89.4, 91.5, 120.0, 152.9\\
        3 & 0.210 & 344.108 & 152.205 & 52.7, 74.3, 84.6, 115.7, 121.9, 151.4, 153.0\\
        4 & 0.210 & 330.026 & 152.205 & 61.7, 77.8, 79.8, 81.7, 82.7, 95.6, 137.6\\
        5 & 0.210 & 345.552 & 152.205 & 29.2, 36.3, 48.6, 152.3\\
        6 & 0.210 & 345.828 & 152.205 & 25.4, 25.9, 30.1, 35.9, 37.7, 83.0, 152.3\\
        7 & 0.210 & 341.545 & 152.205 & 37.0, 42.4, 44.5, 53.5, 90.6, 157.2\\
        8 & 0.210 & 344.126 & 152.205 & 23.0, 25.3, 29.4, 40.1, 49.3, 85.3\\
        9 & 0.130 & 340.890 & 152.205 & 24.9, 29.3, 31.3, 35.3, 41.4, 51.0, 87.1, 152.4\\
        10 & 0.210 & 330.026 & 152.205 & 89.6, 104.6, 109.2, 142.1\\
        11 & 0.210 & 330.026 & 152.205 & 52.5, 57.0, 98.4, 100.9, 108.6\\
        12 & 0.210 & 330.026 & 152.205 & 108.1, 112.2, 115.3, 127.9, 132.4\\
        13 & 0.210 & 330.026 & 152.205 & 105.6, 114.7, 118.0, 127.8, 132.6\\
        14 & 0.210 & 341.573 & 152.205 & 86.0, 96.2, 107.4, 144.4, 145.3, 154.6\\
        15 & 0.210 & 342.106 & 152.205 & 84.1, 95.4, 109.4, 147.3, 149.8, 151.9, 153.9\\
        16 & 0.210 & 342.027 & 152.205 & 84.4, 95.1, 107.2, 145.9, 147.6, 152.6\\
        17 & 0.210 & 340.791 & 152.205 & 85.6, 96.0, 107.7, 145.3, 148.1, 152.5\\
        19 & 0.210 & 339.877 & 152.205 & 85.8, 94.1, 108.6, 146.7, 151.5, 153.6, 155.2\\
    \end{tabular}
\end{table}

\subsection{Assumed doubly knotted state}
\label{subsec:fit-details-fusion-experiment-doubly}
\begin{minipage}[c]{0.7\textwidth}
    \includegraphics[width=\textwidth]{fuzja_kexp_histograms.png}
\end{minipage}
\hfill
\begin{minipage}[c]{0.45\textwidth}
    \begin{itemize}
        \item method = 'stretch-adjust';
        \item $p_{prot}=5.9360$
        \item $k_{prot}=0.0000$
        \item $p_{dna}=0.2016$
        \item $k_{dna}=0.0090$
        \item $l_{dna}=341.713$
        \item states = 12 (33.9, 36.8, 40.8, 80.5, 86.8, 90.1, 103.2, 108.2, 114.9, 137.5, 142.0, 147.4 nm);
    \end{itemize}
\end{minipage}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{fuzja_kexp_contour_lengths_1.png}
    \caption{All fusion experimental traces assuming doubly knotted protein.}
    \label{fig:doubly-fusion-kexp-cl1}
\end{figure}

\begin{figure}
    \centering
    \includegraphics[width=\linewidth]{fuzja_kexp_contour_lengths_2.png}
    \caption{All fusion experimental traces assuming doubly knotted protein (continued).}
    \label{fig:doubly-fusion-exp-cl2}
\end{figure}

\begin{table}
    \tiny
    \centering
    \caption{The fit parameters for fusion (experiment, assumed doubly knotted).}
    \label{tab:fusion-fit-parameters-exp-doubly}
    \begin{tabular}{c|c|c|c|c}
        \textbf{Trace} & $p_{dna}$ & $l_{dna}$ & $l_{prot}$ & states [nm]\\\hline
        1 & 0.130 & 339.565 & 147.095 & 48.8, 63.1, 76.8, 85.7, 87.8, 97.3, 99.8, 123.5, 147.1\\
        2 & 0.210 & 348.236 & 147.095 & 46.5, 52.2, 54.2, 70.9, 80.5, 84.0, 86.3, 114.8, 147.7\\
        3 & 0.210 & 347.801 & 147.095 & 46.6, 51.3, 69.5, 79.4, 110.6, 116.8, 146.3, 147.9\\
        4 & 0.210 & 330.026 & 147.095 & 61.7, 77.8, 79.8, 81.7, 82.7, 95.6, 137.6\\
        5 & 0.210 & 349.240 & 147.095 & 23.8, 27.7, 31.8, 43.6, 147.2\\
        6 & 0.210 & 349.518 & 147.095 & 18.3, 24.2, 30.6, 32.2, 37.1, 77.9, 147.2\\
        7 & 0.210 & 345.432 & 147.095 & 31.2, 38.9, 48.1, 85.2, 151.8, 0.0, 0.0, 31.2, 38.9, 48.1, 85.2, 151.8\\
        8 & 0.210 & 347.819 & 147.095 & 19.3, 34.8, 44.2, 80.1\\
        9 & 0.130 & 344.549 & 147.095 & 18.9, 22.8, 24.6, 26.0, 29.8, 36.2, 45.7, 81.9, 147.3\\
        10 & 0.210 & 330.026 & 147.095 & 89.6, 104.6, 109.2, 142.1\\
        11 & 0.210 & 330.026 & 147.095 & 52.5, 57.0, 98.4, 100.9, 108.6\\
        12 & 0.210 & 330.026 & 147.095 & 108.1, 112.2, 115.3, 127.9, 132.4\\
        13 & 0.210 & 330.026 & 147.095 & 105.6, 114.7, 118.0, 127.8, 132.6\\
        14 & 0.210 & 345.204 & 147.095 & 79.9, 90.7, 139.1, 140.2, 149.5\\
        15 & 0.210 & 345.810 & 147.095 & 78.0, 90.0, 104.3, 142.2, 144.7, 146.8, 148.8\\
        16 & 0.210 & 345.733 & 147.095 & 78.2, 89.4, 101.9, 140.7, 142.5, 147.5\\
        17 & 0.210 & 344.503 & 147.095 & 79.0, 90.5, 102.4, 140.1, 142.9, 147.3\\
        19 & 0.210 & 343.581 & 147.095 & 79.9, 89.0, 103.2, 141.4, 143.7, 146.3, 148.4, 150.0\\
    \end{tabular}
\end{table}