xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT05962775</url>
    </required_header>
    <id_info>
      <org_study_id>AUTF</org_study_id>
      <nct_id>NCT05962775</nct_id>
    </id_info>
    <brief_title>Ethanol Sclerotherapy Prior to ART</brief_title>
    <acronym>START</acronym>
    <official_title>The Impact of Ethanol Sclerotherapy Before ART (Assisted Reproductive Technology) Cycle on Cumulative Live Birth Rate in Infertile Women With Endometrioma: A Randomized Controlled Trial</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Ankara University</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
      <collaborator>
        <agency>Hacettepe University</agency>
        <agency_class>Other</agency_class>
      </collaborator>
    </sponsors>
    <source>Ankara University</source>
    <oversight_info>
      <has_dmc>Yes</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        The goal of this randomized controlled trial is to assess the impact of ethanol sclerotherapy&#xD;
        on ART cycle outcomes. The main questions it aims to answer are:&#xD;
  &#xD;
          1. Does ethanol sclerotherapy before ART cycle has any impact on cumulative live birth rate&#xD;
             in patients with endometrioma?&#xD;
  &#xD;
          2. Does ethanol sclerotherapy improve chronic pelvic pain, dysmenorrhea, complications&#xD;
             during oocyte retrieval, response to ovarian stimulation (number of mature oocytes&#xD;
             retrieved), and pregnancy loss rates?&#xD;
  &#xD;
        Infertile patients with endometrioma between 4-10 cm who are scheduled for ART within 2&#xD;
        cycles will be randomized to ethanol sclerotherapy or no intervention.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        The effect of ethanol sclerotherapy before assisted reproductive technology (ART) cycle in&#xD;
        patients with endometrioma on reproductive outcomes will be investigated. While endometrioma&#xD;
        may result in technical difficulties in the ART process, the superiority of ethanol&#xD;
        sclerotherapy has yet to be examined before the ART procedure in randomized controlled&#xD;
        studies and meta-analyses. The negative effect of ethanol sclerotherapy on ovarian reserve&#xD;
        was found to be less than other existing interventions such as cyst stripping. However,&#xD;
        randomized controlled studies did not determine its direct effect on ART outcome. Our current&#xD;
        study aimed to assess the effect of ethanol sclerotherapy on ART outcomes.&#xD;
  &#xD;
        Infertile patients aged 18-40 years with at least one endometrioma 4-10 cm and scheduled for&#xD;
        ART will be included in the study. Patients with any untreated thyroid dysfunction or&#xD;
        additional disease, such as hyperprolactinemia, those who did not accept the study&#xD;
        information and consent, and patients younger than 18 or older than 40 will not be included.&#xD;
        Those who underwent surgery for endometrioma within 3 months before ART will be excluded. In&#xD;
        addition, patients with an anti-mullerian hormone value below 0.3 ng/ml will not be included&#xD;
        in the study.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Recruiting</overall_status>
    <start_date type="Actual">May 1, 2023</start_date>
    <completion_date type="Anticipated">April 1, 2025</completion_date>
    <primary_completion_date type="Anticipated">January 1, 2025</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>Randomized</allocation>
      <intervention_model>Parallel Assignment</intervention_model>
      <primary_purpose>Treatment</primary_purpose>
      <masking>None (Open Label)</masking>
    </study_design_info>
    <primary_outcome>
      <measure>Cumulative live birth rate</measure>
      <time_frame>18 months</time_frame>
      <description>live births following fresh and frozen-thaw transfer of all embryos unless pregnancy occurs</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>pain scores</measure>
      <time_frame>3 months</time_frame>
      <description>Visual Analog Pain Scale scores related to dysmenorrhea, dyspareunia, and/or pelvic pain will be measured before and after procedure</description>
    </secondary_outcome>
    <number_of_arms>2</number_of_arms>
    <enrollment type="Anticipated">84</enrollment>
    <condition>Endometrioma</condition>
    <condition>Infertility</condition>
    <condition>Sclerotherapy</condition>
    <condition>ART</condition>
    <condition>IVF</condition>
    <arm_group>
      <arm_group_label>Control</arm_group_label>
      <arm_group_type>No Intervention</arm_group_type>
      <description>In eligible patients allocated to control group, no interventions will be done before ART cycle.</description>
    </arm_group>
    <arm_group>
      <arm_group_label>Ethanol sclerotherapy</arm_group_label>
      <arm_group_type>Experimental</arm_group_type>
      <description>In eligible patients allocated to study group, endometrioma/s will be aspirated and treated with ethanol for 10 minutes 1-2 cycles before ART.</description>
    </arm_group>
    <intervention>
      <intervention_type>Procedure</intervention_type>
      <intervention_name>Ethanol Sclerotherapy for Endometrioma</intervention_name>
      <description>2 gr IV cefazolin sodium will be administered 30 minutes before the procedure. The endometrioma cyst content will be aspirated by a single lumen needle, and the total aspirated volume calculation will be done. The endometrioma will then be washed with saline until the color of the cyst content becomes clear. Then, 96% ethanol will be injected into the cyst. The volume of injected ethanol will be 60% of the first aspirated volume (maximum 100 ml). After 10 minutes all ethanol will be aspirated.</description>
      <arm_group_label>Ethanol sclerotherapy</arm_group_label>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  AMH&gt;0.3 ng/ml&#xD;
  &#xD;
            -  unilateral/bilateral endometrioma&#xD;
  &#xD;
            -  Endometrioma diameter 40-100 mm&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  3 or more IVF/embryo transfer failure&#xD;
  &#xD;
            -  Menstrual cycle abnormalities&#xD;
  &#xD;
            -  Male Factor infertility&#xD;
  &#xD;
            -  Presence of uterine fibroids&#xD;
  &#xD;
            -  Presence of hydrosalpinx&#xD;
  &#xD;
            -  Presence of uterine abnormalities&#xD;
  &#xD;
            -  Suspicion of malignancy according to International Ovarian Tumor Analysis criteria&#xD;
        </textblock>
      </criteria>
      <gender>Female</gender>
      <gender_based>Yes</gender_based>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>40 Years</maximum_age>
      <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Batuhan Aslan</last_name>
      <role>Principal Investigator</role>
      <affiliation>Ankara University</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Yavuz Emre Sukur</last_name>
      <phone>+905332409381</phone>
      <email>yesukur@gmail.com</email>
    </overall_contact>
    <overall_contact_backup>
      <last_name>Sezcan Mumusoglu</last_name>
      <phone>+905326404673</phone>
      <email>sezcanmumusoglu@gmail.com</email>
    </overall_contact_backup>
    <location>
      <facility>
        <name>Ankara University School of Medicine, Department of Obstetrics and Gynecology</name>
        <address>
          <city>Ankara</city>
          <zip>06610</zip>
          <country>Turkey</country>
        </address>
      </facility>
      <status>Recruiting</status>
      <contact>
        <last_name>Yavuz Emre Şükür, M.D.</last_name>
        <phone>00905332409381</phone>
        <email>yesukur@gmail.com</email>
      </contact>
      <contact_backup>
        <last_name>Batuhan Aslan, M.D.</last_name>
        <phone>00905462555335</phone>
        <email>drbatuhanaslan@gmail.com</email>
      </contact_backup>
    </location>
    <location_countries>
      <country>Turkey</country>
    </location_countries>
    <reference>
      <citation>Akamatsu N, Hirai T, Masaoka H, Sekiba K, Fujita T. [Ultrasonically guided puncture of endometrial cysts--aspiration of contents and infusion of ethanol]. Nihon Sanka Fujinka Gakkai Zasshi. 1988 Feb;40(2):187-91. Japanese.</citation>
      <PMID>3283269</PMID>
    </reference>
    <reference>
      <citation>Alborzi S, Ravanbakhsh R, Parsanezhad ME, Alborzi M, Alborzi S, Dehbashi S. A comparison of follicular response of ovaries to ovulation induction after laparoscopic ovarian cystectomy or fenestration and coagulation versus normal ovaries in patients with endometrioma. Fertil Steril. 2007 Aug;88(2):507-9. doi: 10.1016/j.fertnstert.2006.11.134. Epub 2007 Apr 11.</citation>
      <PMID>17433319</PMID>
    </reference>
    <reference>
      <citation>Benaglia L, Busnelli A, Biancardi R, Vegetti W, Reschini M, Vercellini P, Somigliana E. Oocyte retrieval difficulties in women with ovarian endometriomas. Reprod Biomed Online. 2018 Jul;37(1):77-84. doi: 10.1016/j.rbmo.2018.03.020. Epub 2018 Apr 13.</citation>
      <PMID>29759886</PMID>
    </reference>
    <reference>
      <citation>Benaglia L, Somigliana E, Vercellini P, Abbiati A, Ragni G, Fedele L. Endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation. Hum Reprod. 2009 Sep;24(9):2183-6. doi: 10.1093/humrep/dep202. Epub 2009 Jun 5.</citation>
      <PMID>19502358</PMID>
    </reference>
    <reference>
      <citation>Cohen A, Almog B, Tulandi T. Sclerotherapy in the management of ovarian endometrioma: systematic review and meta-analysis. Fertil Steril. 2017 Jul;108(1):117-124.e5. doi: 10.1016/j.fertnstert.2017.05.015. Epub 2017 Jun 1.</citation>
      <PMID>28579409</PMID>
    </reference>
    <reference>
      <citation>Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D'Hooghe T, De Bie B, Heikinheimo O, Horne AW, Kiesel L, Nap A, Prentice A, Saridogan E, Soriano D, Nelen W; European Society of Human Reproduction and Embryology. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014 Mar;29(3):400-12. doi: 10.1093/humrep/det457. Epub 2014 Jan 15.</citation>
      <PMID>24435778</PMID>
    </reference>
    <reference>
      <citation>Garcia-Velasco JA, Somigliana E. Management of endometriomas in women requiring IVF: to touch or not to touch. Hum Reprod. 2009 Mar;24(3):496-501. doi: 10.1093/humrep/den398. Epub 2008 Dec 4.</citation>
      <PMID>19056774</PMID>
    </reference>
    <reference>
      <citation>Hart RJ, Hickey M, Maouris P, Buckett W. Excisional surgery versus ablative surgery for ovarian endometriomata. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD004992. doi: 10.1002/14651858.CD004992.pub3.</citation>
      <PMID>18425908</PMID>
    </reference>
    <reference>
      <citation>Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. Hum Reprod Update. 2019 Sep 11;25(5):592-632. doi: 10.1093/humupd/dmz012.</citation>
      <PMID>31318420</PMID>
    </reference>
    <reference>
      <citation>Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D'Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. 2009 Jul;92(1):68-74. doi: 10.1016/j.fertnstert.2008.04.056. Epub 2008 Aug 5.</citation>
      <PMID>18684448</PMID>
    </reference>
    <reference>
      <citation>Miquel L, Preaubert L, Gnisci A, Netter A, Courbiere B, Agostini A, Pivano A. Transvaginal ethanol sclerotherapy for an endometrioma in 10 steps. Fertil Steril. 2021 Jan;115(1):259-260. doi: 10.1016/j.fertnstert.2020.08.1422. Epub 2020 Oct 8.</citation>
      <PMID>33039127</PMID>
    </reference>
    <reference>
      <citation>Miquel L, Preaubert L, Gnisci A, Resseguier N, Pivano A, Perrin J, Courbiere B. Endometrioma ethanol sclerotherapy could increase IVF live birth rate in women with moderate-severe endometriosis. PLoS One. 2020 Sep 28;15(9):e0239846. doi: 10.1371/journal.pone.0239846. eCollection 2020.</citation>
      <PMID>32986747</PMID>
    </reference>
    <reference>
      <citation>Roustan A, Perrin J, Debals-Gonthier M, Paulmyer-Lacroix O, Agostini A, Courbiere B. Surgical diminished ovarian reserve after endometrioma cystectomy versus idiopathic DOR: comparison of in vitro fertilization outcome. Hum Reprod. 2015 Apr;30(4):840-7. doi: 10.1093/humrep/dev029. Epub 2015 Mar 3.</citation>
      <PMID>25740883</PMID>
    </reference>
    <reference>
      <citation>Rubod C, Jean Dit Gautier E, Yazbeck C. [Surgical management of endometrioma: Different alternatives in term of pain, fertility and recurrence. CNGOF-HAS Endometriosis Guidelines]. Gynecol Obstet Fertil Senol. 2018 Mar;46(3):278-289. doi: 10.1016/j.gofs.2018.02.013. Epub 2018 Mar 3. French.</citation>
      <PMID>29510964</PMID>
    </reference>
    <reference>
      <citation>Somigliana E, Benaglia L, Paffoni A, Busnelli A, Vigano P, Vercellini P. Risks of conservative management in women with ovarian endometriomas undergoing IVF. Hum Reprod Update. 2015 Jul-Aug;21(4):486-99. doi: 10.1093/humupd/dmv012. Epub 2015 Mar 6.</citation>
      <PMID>25750209</PMID>
    </reference>
    <reference>
      <citation>Sukur YE, Ozmen B, Yakistiran B, Atabekoglu CS, Berker B, Aytac R, Sonmezer M. Endometrioma surgery is associated with increased risk of subsequent assisted reproductive technology cycle cancellation; a retrospective cohort study. J Obstet Gynaecol. 2021 Feb;41(2):259-262. doi: 10.1080/01443615.2020.1754366. Epub 2020 Jun 4.</citation>
      <PMID>32496142</PMID>
    </reference>
    <reference>
      <citation>Yazbeck C, Madelenat P, Ayel JP, Jacquesson L, Bontoux LM, Solal P, Hazout A. Ethanol sclerotherapy: a treatment option for ovarian endometriomas before ovarian stimulation. Reprod Biomed Online. 2009 Jul;19(1):121-5. doi: 10.1016/s1472-6483(10)60055-7.</citation>
      <PMID>19573300</PMID>
    </reference>
    <reference>
      <citation>Yazbeck C, Koskas M, Cohen Scali S, Kahn V, Luton D, Madelenat P. [How I do... ethanol sclerotherapy for ovarian endometriomas]. Gynecol Obstet Fertil. 2012 Oct;40(10):620-2. doi: 10.1016/j.gyobfe.2012.07.029. Epub 2012 Sep 5. No abstract available. French.</citation>
      <PMID>22959083</PMID>
    </reference>
    <verification_date>July 2023</verification_date>
    <study_first_submitted>July 19, 2023</study_first_submitted>
    <study_first_submitted_qc>July 19, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">July 27, 2023</study_first_posted>
    <last_update_submitted>July 19, 2023</last_update_submitted>
    <last_update_submitted_qc>July 19, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">July 27, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Principal Investigator</responsible_party_type>
      <investigator_affiliation>Ankara University</investigator_affiliation>
      <investigator_full_name>Yavuz Emre Şükür</investigator_full_name>
      <investigator_title>associate professor</investigator_title>
    </responsible_party>
    <keyword>endometrioma</keyword>
    <keyword>ethanol sclerotherapy</keyword>
    <keyword>assisted reproductive technology</keyword>
    <keyword>in vitro fertilization</keyword>
    <keyword>cumulative live birth rate</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Infertility</mesh_term>
      <mesh_term>Endometriosis</mesh_term>
    </condition_browse>
    <intervention_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Ethanol</mesh_term>
    </intervention_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT05962775
  org study id: AUTF
  nct id: NCT05962775
  lead sponsor: 
  collaborator: 
  has dmc: Yes
  is fda regulated drug: No
  is fda regulated device: No
  The goal of this randomized controlled trial is to assess the impact of ethanol sclerotherapy
        on ART cycle outcomes. The main questions it aims to answer are:
  
          1. Does ethanol sclerotherapy before ART cycle has any impact on cumulative live birth rate
             in patients with endometrioma?
  
          2. Does ethanol sclerotherapy improve chronic pelvic pain, dysmenorrhea, complications
             during oocyte retrieval, response to ovarian stimulation (number of mature oocytes
             retrieved), and pregnancy loss rates?
  
        Infertile patients with endometrioma between 4-10 cm who are scheduled for ART within 2
        cycles will be randomized to ethanol sclerotherapy or no intervention.
  The effect of ethanol sclerotherapy before assisted reproductive technology (ART) cycle in
        patients with endometrioma on reproductive outcomes will be investigated. While endometrioma
        may result in technical difficulties in the ART process, the superiority of ethanol
        sclerotherapy has yet to be examined before the ART procedure in randomized controlled
        studies and meta-analyses. The negative effect of ethanol sclerotherapy on ovarian reserve
        was found to be less than other existing interventions such as cyst stripping. However,
        randomized controlled studies did not determine its direct effect on ART outcome. Our current
        study aimed to assess the effect of ethanol sclerotherapy on ART outcomes.
  
        Infertile patients aged 18-40 years with at least one endometrioma 4-10 cm and scheduled for
        ART will be included in the study. Patients with any untreated thyroid dysfunction or
        additional disease, such as hyperprolactinemia, those who did not accept the study
        information and consent, and patients younger than 18 or older than 40 will not be included.
        Those who underwent surgery for endometrioma within 3 months before ART will be excluded. In
        addition, patients with an anti-mullerian hormone value below 0.3 ng/ml will not be included
        in the study.
  allocation: Randomized
  intervention model: Parallel Assignment
  primary purpose: Treatment
  masking: None (Open Label)
  measure: Cumulative live birth rate
  time frame: 18 months
  description: live births following fresh and frozen-thaw transfer of all embryos unless pregnancy occurs
  measure: pain scores
  time frame: 3 months
  description: Visual Analog Pain Scale scores related to dysmenorrhea, dyspareunia, and/or pelvic pain will be measured before and after procedure
  arm group label: Control
  arm group type: No Intervention
  description: In eligible patients allocated to control group, no interventions will be done before ART cycle.
  arm group label: Ethanol sclerotherapy
  arm group type: Experimental
  description: In eligible patients allocated to study group, endometrioma/s will be aspirated and treated with ethanol for 10 minutes 1-2 cycles before ART.
  intervention type: Procedure
  intervention name: Ethanol Sclerotherapy for Endometrioma
  description: 2 gr IV cefazolin sodium will be administered 30 minutes before the procedure. The endometrioma cyst content will be aspirated by a single lumen needle, and the total aspirated volume calculation will be done. The endometrioma will then be washed with saline until the color of the cyst content becomes clear. Then, 96% ethanol will be injected into the cyst. The volume of injected ethanol will be 60% of the first aspirated volume (maximum 100 ml). After 10 minutes all ethanol will be aspirated.
  arm group label: Ethanol sclerotherapy
  criteria: 
  gender: Female
  gender based: Yes
  minimum age: 18 Years
  maximum age: 40 Years
  healthy volunteers: Accepts Healthy Volunteers
  last name: Batuhan Aslan
  role: Principal Investigator
  affiliation: Ankara University
  last name: Yavuz Emre Sukur
  phone: +905332409381
  email: yesukur@gmail.com
  last name: Sezcan Mumusoglu
  phone: +905326404673
  email: sezcanmumusoglu@gmail.com
  facility: 
  status: Recruiting
  contact: 
  contact backup: 
  country: Turkey
  citation: Akamatsu N, Hirai T, Masaoka H, Sekiba K, Fujita T. [Ultrasonically guided puncture of endometrial cysts--aspiration of contents and infusion of ethanol]. Nihon Sanka Fujinka Gakkai Zasshi. 1988 Feb;40(2):187-91. Japanese.
  PMID: 3283269
  citation: Alborzi S, Ravanbakhsh R, Parsanezhad ME, Alborzi M, Alborzi S, Dehbashi S. A comparison of follicular response of ovaries to ovulation induction after laparoscopic ovarian cystectomy or fenestration and coagulation versus normal ovaries in patients with endometrioma. Fertil Steril. 2007 Aug;88(2):507-9. doi: 10.1016/j.fertnstert.2006.11.134. Epub 2007 Apr 11.
  PMID: 17433319
  citation: Benaglia L, Busnelli A, Biancardi R, Vegetti W, Reschini M, Vercellini P, Somigliana E. Oocyte retrieval difficulties in women with ovarian endometriomas. Reprod Biomed Online. 2018 Jul;37(1):77-84. doi: 10.1016/j.rbmo.2018.03.020. Epub 2018 Apr 13.
  PMID: 29759886
  citation: Benaglia L, Somigliana E, Vercellini P, Abbiati A, Ragni G, Fedele L. Endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation. Hum Reprod. 2009 Sep;24(9):2183-6. doi: 10.1093/humrep/dep202. Epub 2009 Jun 5.
  PMID: 19502358
  citation: Cohen A, Almog B, Tulandi T. Sclerotherapy in the management of ovarian endometrioma: systematic review and meta-analysis. Fertil Steril. 2017 Jul;108(1):117-124.e5. doi: 10.1016/j.fertnstert.2017.05.015. Epub 2017 Jun 1.
  PMID: 28579409
  citation: Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D'Hooghe T, De Bie B, Heikinheimo O, Horne AW, Kiesel L, Nap A, Prentice A, Saridogan E, Soriano D, Nelen W; European Society of Human Reproduction and Embryology. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014 Mar;29(3):400-12. doi: 10.1093/humrep/det457. Epub 2014 Jan 15.
  PMID: 24435778
  citation: Garcia-Velasco JA, Somigliana E. Management of endometriomas in women requiring IVF: to touch or not to touch. Hum Reprod. 2009 Mar;24(3):496-501. doi: 10.1093/humrep/den398. Epub 2008 Dec 4.
  PMID: 19056774
  citation: Hart RJ, Hickey M, Maouris P, Buckett W. Excisional surgery versus ablative surgery for ovarian endometriomata. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD004992. doi: 10.1002/14651858.CD004992.pub3.
  PMID: 18425908
  citation: Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. Hum Reprod Update. 2019 Sep 11;25(5):592-632. doi: 10.1093/humupd/dmz012.
  PMID: 31318420
  citation: Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D'Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. 2009 Jul;92(1):68-74. doi: 10.1016/j.fertnstert.2008.04.056. Epub 2008 Aug 5.
  PMID: 18684448
  citation: Miquel L, Preaubert L, Gnisci A, Netter A, Courbiere B, Agostini A, Pivano A. Transvaginal ethanol sclerotherapy for an endometrioma in 10 steps. Fertil Steril. 2021 Jan;115(1):259-260. doi: 10.1016/j.fertnstert.2020.08.1422. Epub 2020 Oct 8.
  PMID: 33039127
  citation: Miquel L, Preaubert L, Gnisci A, Resseguier N, Pivano A, Perrin J, Courbiere B. Endometrioma ethanol sclerotherapy could increase IVF live birth rate in women with moderate-severe endometriosis. PLoS One. 2020 Sep 28;15(9):e0239846. doi: 10.1371/journal.pone.0239846. eCollection 2020.
  PMID: 32986747
  citation: Roustan A, Perrin J, Debals-Gonthier M, Paulmyer-Lacroix O, Agostini A, Courbiere B. Surgical diminished ovarian reserve after endometrioma cystectomy versus idiopathic DOR: comparison of in vitro fertilization outcome. Hum Reprod. 2015 Apr;30(4):840-7. doi: 10.1093/humrep/dev029. Epub 2015 Mar 3.
  PMID: 25740883
  citation: Rubod C, Jean Dit Gautier E, Yazbeck C. [Surgical management of endometrioma: Different alternatives in term of pain, fertility and recurrence. CNGOF-HAS Endometriosis Guidelines]. Gynecol Obstet Fertil Senol. 2018 Mar;46(3):278-289. doi: 10.1016/j.gofs.2018.02.013. Epub 2018 Mar 3. French.
  PMID: 29510964
  citation: Somigliana E, Benaglia L, Paffoni A, Busnelli A, Vigano P, Vercellini P. Risks of conservative management in women with ovarian endometriomas undergoing IVF. Hum Reprod Update. 2015 Jul-Aug;21(4):486-99. doi: 10.1093/humupd/dmv012. Epub 2015 Mar 6.
  PMID: 25750209
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  PMID: 22959083
  responsible party type: Principal Investigator
  investigator affiliation: Ankara University
  investigator full name: Yavuz Emre Şükür
  investigator title: associate professor
  mesh term: Infertility
  mesh term: Endometriosis
  mesh term: Ethanol
  sharing ipd: No