xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT06000644</url>
    </required_header>
    <id_info>
      <org_study_id>CMRPD1M0841</org_study_id>
      <nct_id>NCT06000644</nct_id>
    </id_info>
    <brief_title>Effects of Combined Cognitive Training and Rhythmic Auditory Stimulation in Treadmill Training After Stroke</brief_title>
    <official_title>Effects of Progressive Combined Cognitive Training and Rhythmic Auditory Stimulation in Treadmill Training on Walking Automaticity, Executive Function, and Dual-task Coordination for Patients With Chronic Stroke</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Chang Gung University</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Chang Gung University</source>
    <oversight_info>
      <has_dmc>No</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        The objective of this study is to compare the effects of progressive combined cognitive&#xD;
        training and rhythmic auditory stimulation to treadmill training (combined group), cognitive&#xD;
        treadmill training (cognitive group), rhythmic auditory stimulation to treadmill training&#xD;
        (rhythmic group), and treadmill walking alone (treadmill group) on walking automaticity,&#xD;
        executive function, and dual-task coordination for patients with chronic stroke (Aim 1). The&#xD;
        second aim of this study is to investigate the factors affecting the results of interventions&#xD;
        (Aim 2). The third aim of the study is to examine the characteristics of stroke population&#xD;
        who are appropriate for progressive combined cognitive training and rhythmic auditory&#xD;
        stimulation to treadmill training.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        A single-blinded, randomized controlled trial will be conducted at medical centers. Eighty&#xD;
        stroke patients will be randomized to one of the four groups. All groups will receive&#xD;
        interventions 30 minutes per time, 3 times a week, for 4 weeks. The combined group will&#xD;
        undertake progressive treadmill walking speed and rhythmic auditory stimulation while&#xD;
        performing a cognitive task. The cognitive group will receive cognitive training while&#xD;
        walking on the treadmill. The rhythmic group will hear rhythmic auditory stimulation while&#xD;
        treadmill walking. The treadmill group will train only in progressive treadmill walking. A&#xD;
        blinded assessor will administer three assessments. All participants will be examined for&#xD;
        gait and cognitive performance under single-task (walking only, Stroop task only) and&#xD;
        dual-task conditions (walking while performing the Stroop task) at baseline,&#xD;
        post-intervention, and one-month follow-up. The primary outcome measures of gait and&#xD;
        cognition are gait speed and cognitive score of the Stroop task under single- and dual-task&#xD;
        conditions. The secondary outcome measures are the Mini-BESTest, Walking Ability&#xD;
        Questionnaire, 6-minute Walk Test, and Stroke Impact Scale. Repeated measure ANOVA will be&#xD;
        used to compare measurements at baseline, after training, and follow-up between and within&#xD;
        the groups.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Not yet recruiting</overall_status>
    <start_date type="Anticipated">September 1, 2023</start_date>
    <completion_date type="Anticipated">July 31, 2026</completion_date>
    <primary_completion_date type="Anticipated">July 31, 2026</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>Randomized</allocation>
      <intervention_model>Parallel Assignment</intervention_model>
      <primary_purpose>Treatment</primary_purpose>
      <masking>Single (Outcomes Assessor)</masking>
    </study_design_info>
    <primary_outcome>
      <measure>Walking speed (m/s)</measure>
      <time_frame>5 minutes</time_frame>
      <description>Participants will walk 10 meters at their preferred speed with and without the Stroop task twice, respectively. The spatiotemporal gait parameters will be examined using Physilog® sensors (Gait Up, Switzerland) and analyzed by the Gait Analysis Package software on the USB key. Walking speed (m/s) is the mean speed of forward walking, calculated in meters per second.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Stride time variability (%)</measure>
      <time_frame>5 minutes</time_frame>
      <description>The stride time is the duration of one cycle (from heel strike to heel strike of the same side). Stride time variability (%) is the coefficient of variation of stride time or cycle duration in percent.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Gait asymmetry (%)</measure>
      <time_frame>5 minutes</time_frame>
      <description>Gait asymmetry will be assessed by comparing left and right swing time, in percent. A perfect symmetry outputs a value of 0%.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Cognitive composite score</measure>
      <time_frame>5 minutes</time_frame>
      <description>The Stroop task is the commonly utilized dual-task paradigm and measures executive function and response inhibition, which plays a vital role during walking. Therefore, the Stroop task will be selected to assess cognitive dual-task walking. The Stroop task will be performed while sitting and walking to assess executive function under single-task and dual-task conditions. The following is the formula for calculating the cognitive composite score: Cognitive composite score of the Stroop task = [Accuracy(%)/Reaction time(milliseconds)] * 100. The better the cognitive performance of the Stroop task, the higher the cognitive composite score.&#xD;
  The instructions for the dual-task walking (walking + Stroop) are designed to encourage neutral prioritization between the two tasks (&quot;walk at the preferred speed while performing the Stroop task as accurately and quickly as you can&quot;).</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Dual-task automaticity</measure>
      <time_frame>5 minutes</time_frame>
      <description>Automaticity is based on the combined interference of both motor (i.e., walking speed) and cognitive DTE. The combined dual-task effect (cDTE) is a measure that quantifies automaticity while performing a dual-task. The walking speed and cognitive composite score under single-task and dual-task conditions will be used to calculate combined DTE.A negative cDTE value is indicative of automaticity under dual-task that deteriorated or interfered. A positive cDTE value indicates automaticity facilitation.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Task-specific dual-task interference</measure>
      <time_frame>5 minutes</time_frame>
      <description>Task-specific dual-task interference calculates the motor (i.e., walking speed) or cognitive dual-task effect (DTE), which relates dual-task performance to single-task performance. For assessing dual-task interference, quantifying the combined interference of the motor and the cognitive tasks may be a more comprehensive measure of the dual-task effect to provide a more accurate picture of gait automaticity. The walking speed and cognitive composite score will be used to calculate motor and cognitive dual-task effect (DTE). For both the motor (i.e., walking speed) and cognitive DTE in this study, negative DTE values (i.e., dual-task interfence) indicate poor performance under dual-task walking condition compared to single-task conditions.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>6-minute Walking test, 6MWT</measure>
      <time_frame>6 minutes</time_frame>
      <description>The 6-minute walk test will be used to measure participants' walking capacity and walking endurance.The participants will ask to walk for six minutes at their own pace, resting or slowing down as needed, and the total distance (meters) of walking in six minutes will be recorded</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Stroke impact scale, SIS</measure>
      <time_frame>10 minutes</time_frame>
      <description>The SIS was developed to measure the quality of life after a stroke. The SIS 3.0 has eight domains: strength, hand function, mobility, activities of daily living/instrumental activities of daily living (i.e., ADLs and IADLs), memory and thinking, communication, emotion, and social participation. Scores for each domain range from 0 to 100, and higher scores indicate a better health-related quality of life. Lower scores indicate more incredible difficulty in task completion during the past week or past two weeks, or past four weeks. Eight items on the social participation domain and eight items on the mobility domain of the SIS will be used to measure the social participation of individuals with chronic stroke in this study.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Mini-Balance Evaluation System Test, Mini-BESTest</measure>
      <time_frame>10 minutes</time_frame>
      <description>The Mini-BESTest is a reliable and valid tool for evaluating balance in people with chronic stroke. It consists of 14 items and includes four subscales: anticipatory postural adjustments, reactive postural control, sensory orientation, and dynamic gait. Each test item is rated on a three-point ordinal scale (0-2, 0=severe, 1=moderate, and 2=normal), with the total score ranging between 0 and 28 points.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Walking ability questionnaire</measure>
      <time_frame>5 minutes</time_frame>
      <description>The walking ability questionnaire was designed to provide a more detailed assessment of the individual's social limitations due to reduced walking ability. A research assistant will administer the questionnaire to rate the participant's current customary mobility of 19 ambulatory activities performed in the home (8 items) and community (11 items). Current customary mobility was defined as an individual's self-reported ability to enter and leave the listed locations. Each test item is rated on a five-point ordinal scale (0-4, 0= unable, 1= wheelchair, 2=&quot;assisted, 3= supervised, 4= independent). An overall score was calculated. The range of scale was 0 to 76.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Outdoor walking assessment</measure>
      <time_frame>15 minutes</time_frame>
      <description>Participants will walk 400 meters at their comfortable speed on the street. A 402-meter walkway will be used for outdoor walking test. In order to allow the participants to have enough distance to accelerate and decelerate, only the time taken the middle 400 meters will be recorded by a stopwatch. The outcome measure will be walking speed (m/s).</description>
    </secondary_outcome>
    <number_of_arms>4</number_of_arms>
    <enrollment type="Anticipated">80</enrollment>
    <condition>Stroke</condition>
    <arm_group>
      <arm_group_label>combined group</arm_group_label>
      <arm_group_type>Experimental</arm_group_type>
      <description>The combined group will undertake progressive treadmill walking speed while performing a cognitive task with rhythmic auditory cueing.</description>
    </arm_group>
    <arm_group>
      <arm_group_label>cognitive group</arm_group_label>
      <arm_group_type>Active Comparator</arm_group_type>
      <description>The cognitive group will receive cognitive training while walking on the treadmill.</description>
    </arm_group>
    <arm_group>
      <arm_group_label>rhythmic group</arm_group_label>
      <arm_group_type>Active Comparator</arm_group_type>
      <description>The rhythmic group will hear rhythmic auditory stimulation while treadmill walking.</description>
    </arm_group>
    <arm_group>
      <arm_group_label>treadmill group</arm_group_label>
      <arm_group_type>Active Comparator</arm_group_type>
      <description>The treadmill group will train only in progressive treadmill walking.</description>
    </arm_group>
    <intervention>
      <intervention_type>Device</intervention_type>
      <intervention_name>Combined group</intervention_name>
      <description>The combined group will undertake progressive treadmill walking speed while performing a cognitive task with rhythmic auditory cueing for 30 minutes per session, 3 times a week for 4 weeks.</description>
      <arm_group_label>combined group</arm_group_label>
    </intervention>
    <intervention>
      <intervention_type>Device</intervention_type>
      <intervention_name>Cognitive group</intervention_name>
      <description>The cognitive group will receive cognitive training while treadmill walking with a progressive speed for 30 minutes per session, 3 times a week for 4 weeks .</description>
      <arm_group_label>cognitive group</arm_group_label>
    </intervention>
    <intervention>
      <intervention_type>Device</intervention_type>
      <intervention_name>Rhythmic group</intervention_name>
      <description>The rhythmic group will hear rhythmic auditory stimulation while treadmill walking for 30 minutes per session, 3 times a week for 4 weeks.</description>
      <arm_group_label>rhythmic group</arm_group_label>
    </intervention>
    <intervention>
      <intervention_type>Device</intervention_type>
      <intervention_name>Treadmill group</intervention_name>
      <description>The treadmill group will train only in progressive treadmill walking for 30 minutes per session, 3 times a week for 4 weeks.</description>
      <arm_group_label>treadmill group</arm_group_label>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            1. diagnosed with first-time stroke;&#xD;
  &#xD;
            2. more than 6 months after stroke onset;&#xD;
  &#xD;
            3. able to walk 10 meters;&#xD;
  &#xD;
            4. no severe vision, hearing, or speech impairments;&#xD;
  &#xD;
            5. understand and follow the instructions and sign the Informed Consent Form;&#xD;
  &#xD;
            6. older than 20 years old.&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            1. orthopedic problems affecting walking or other diseases that may interfere with study&#xD;
               participation;&#xD;
  &#xD;
            2. a score of less than 24 on the mini-mental state examination (MMSE);&#xD;
  &#xD;
            3. severe balance disorder with a total score of less than 45 points Berg Balance Scale.&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>20 Years</minimum_age>
      <maximum_age>85 Years</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Li-Ling Chuang, Ph.D.</last_name>
      <role>Principal Investigator</role>
      <affiliation>Chang Gung University</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Li-Ling Chuang, Ph.D.</last_name>
      <phone>886-3-2118800</phone>
      <phone_ext>3177</phone_ext>
      <email>lchunag@gap.cgu.edu.tw</email>
    </overall_contact>
    <overall_contact_backup>
      <last_name>Li-Ling Chuang, Ph.D.</last_name>
      <phone>886-3-2118800</phone>
      <phone_ext>3177</phone_ext>
      <email>lchuang@mail.cgu.edu.tw</email>
    </overall_contact_backup>
    <location>
      <facility>
        <name>Mackay Memory Hospital</name>
        <address>
          <city>Taipei</city>
          <country>Taiwan</country>
        </address>
      </facility>
      <contact>
        <last_name>Li-Ling Chuang, Ph.D.</last_name>
        <phone>886-3-2118800</phone>
        <phone_ext>3177</phone_ext>
        <email>lchuang@gap.cgu.edu.tw</email>
      </contact>
    </location>
    <location_countries>
      <country>Taiwan</country>
    </location_countries>
    <verification_date>August 2023</verification_date>
    <study_first_submitted>August 11, 2023</study_first_submitted>
    <study_first_submitted_qc>August 17, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 21, 2023</study_first_posted>
    <last_update_submitted>August 17, 2023</last_update_submitted>
    <last_update_submitted_qc>August 17, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">August 21, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Principal Investigator</responsible_party_type>
      <investigator_affiliation>Chang Gung University</investigator_affiliation>
      <investigator_full_name>Li-Ling Chuang</investigator_full_name>
      <investigator_title>Associated Professor</investigator_title>
    </responsible_party>
    <keyword>stroke</keyword>
    <keyword>gait rehabilitation</keyword>
    <keyword>rhythmic auditory stimulation</keyword>
    <keyword>cognitive training</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Stroke</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT06000644
  org study id: CMRPD1M0841
  nct id: NCT06000644
  lead sponsor: 
  has dmc: No
  is fda regulated drug: No
  is fda regulated device: No
  The objective of this study is to compare the effects of progressive combined cognitive
        training and rhythmic auditory stimulation to treadmill training (combined group), cognitive
        treadmill training (cognitive group), rhythmic auditory stimulation to treadmill training
        (rhythmic group), and treadmill walking alone (treadmill group) on walking automaticity,
        executive function, and dual-task coordination for patients with chronic stroke (Aim 1). The
        second aim of this study is to investigate the factors affecting the results of interventions
        (Aim 2). The third aim of the study is to examine the characteristics of stroke population
        who are appropriate for progressive combined cognitive training and rhythmic auditory
        stimulation to treadmill training.
  A single-blinded, randomized controlled trial will be conducted at medical centers. Eighty
        stroke patients will be randomized to one of the four groups. All groups will receive
        interventions 30 minutes per time, 3 times a week, for 4 weeks. The combined group will
        undertake progressive treadmill walking speed and rhythmic auditory stimulation while
        performing a cognitive task. The cognitive group will receive cognitive training while
        walking on the treadmill. The rhythmic group will hear rhythmic auditory stimulation while
        treadmill walking. The treadmill group will train only in progressive treadmill walking. A
        blinded assessor will administer three assessments. All participants will be examined for
        gait and cognitive performance under single-task (walking only, Stroop task only) and
        dual-task conditions (walking while performing the Stroop task) at baseline,
        post-intervention, and one-month follow-up. The primary outcome measures of gait and
        cognition are gait speed and cognitive score of the Stroop task under single- and dual-task
        conditions. The secondary outcome measures are the Mini-BESTest, Walking Ability
        Questionnaire, 6-minute Walk Test, and Stroke Impact Scale. Repeated measure ANOVA will be
        used to compare measurements at baseline, after training, and follow-up between and within
        the groups.
  allocation: Randomized
  intervention model: Parallel Assignment
  primary purpose: Treatment
  masking: Single (Outcomes Assessor)
  measure: Walking speed (m/s)
  time frame: 5 minutes
  description: Participants will walk 10 meters at their preferred speed with and without the Stroop task twice, respectively. The spatiotemporal gait parameters will be examined using Physilog® sensors (Gait Up, Switzerland) and analyzed by the Gait Analysis Package software on the USB key. Walking speed (m/s) is the mean speed of forward walking, calculated in meters per second.
  measure: Stride time variability (%)
  time frame: 5 minutes
  description: The stride time is the duration of one cycle (from heel strike to heel strike of the same side). Stride time variability (%) is the coefficient of variation of stride time or cycle duration in percent.
  measure: Gait asymmetry (%)
  time frame: 5 minutes
  description: Gait asymmetry will be assessed by comparing left and right swing time, in percent. A perfect symmetry outputs a value of 0%.
  measure: Cognitive composite score
  time frame: 5 minutes
  description: The Stroop task is the commonly utilized dual-task paradigm and measures executive function and response inhibition, which plays a vital role during walking. Therefore, the Stroop task will be selected to assess cognitive dual-task walking. The Stroop task will be performed while sitting and walking to assess executive function under single-task and dual-task conditions. The following is the formula for calculating the cognitive composite score: Cognitive composite score of the Stroop task = [Accuracy(%)/Reaction time(milliseconds)] * 100. The better the cognitive performance of the Stroop task, the higher the cognitive composite score.
  The instructions for the dual-task walking (walking + Stroop) are designed to encourage neutral prioritization between the two tasks ("walk at the preferred speed while performing the Stroop task as accurately and quickly as you can").
  measure: Dual-task automaticity
  time frame: 5 minutes
  description: Automaticity is based on the combined interference of both motor (i.e., walking speed) and cognitive DTE. The combined dual-task effect (cDTE) is a measure that quantifies automaticity while performing a dual-task. The walking speed and cognitive composite score under single-task and dual-task conditions will be used to calculate combined DTE.A negative cDTE value is indicative of automaticity under dual-task that deteriorated or interfered. A positive cDTE value indicates automaticity facilitation.
  measure: Task-specific dual-task interference
  time frame: 5 minutes
  description: Task-specific dual-task interference calculates the motor (i.e., walking speed) or cognitive dual-task effect (DTE), which relates dual-task performance to single-task performance. For assessing dual-task interference, quantifying the combined interference of the motor and the cognitive tasks may be a more comprehensive measure of the dual-task effect to provide a more accurate picture of gait automaticity. The walking speed and cognitive composite score will be used to calculate motor and cognitive dual-task effect (DTE). For both the motor (i.e., walking speed) and cognitive DTE in this study, negative DTE values (i.e., dual-task interfence) indicate poor performance under dual-task walking condition compared to single-task conditions.
  measure: 6-minute Walking test, 6MWT
  time frame: 6 minutes
  description: The 6-minute walk test will be used to measure participants' walking capacity and walking endurance.The participants will ask to walk for six minutes at their own pace, resting or slowing down as needed, and the total distance (meters) of walking in six minutes will be recorded
  measure: Stroke impact scale, SIS
  time frame: 10 minutes
  description: The SIS was developed to measure the quality of life after a stroke. The SIS 3.0 has eight domains: strength, hand function, mobility, activities of daily living/instrumental activities of daily living (i.e., ADLs and IADLs), memory and thinking, communication, emotion, and social participation. Scores for each domain range from 0 to 100, and higher scores indicate a better health-related quality of life. Lower scores indicate more incredible difficulty in task completion during the past week or past two weeks, or past four weeks. Eight items on the social participation domain and eight items on the mobility domain of the SIS will be used to measure the social participation of individuals with chronic stroke in this study.
  measure: Mini-Balance Evaluation System Test, Mini-BESTest
  time frame: 10 minutes
  description: The Mini-BESTest is a reliable and valid tool for evaluating balance in people with chronic stroke. It consists of 14 items and includes four subscales: anticipatory postural adjustments, reactive postural control, sensory orientation, and dynamic gait. Each test item is rated on a three-point ordinal scale (0-2, 0=severe, 1=moderate, and 2=normal), with the total score ranging between 0 and 28 points.
  measure: Walking ability questionnaire
  time frame: 5 minutes
  description: The walking ability questionnaire was designed to provide a more detailed assessment of the individual's social limitations due to reduced walking ability. A research assistant will administer the questionnaire to rate the participant's current customary mobility of 19 ambulatory activities performed in the home (8 items) and community (11 items). Current customary mobility was defined as an individual's self-reported ability to enter and leave the listed locations. Each test item is rated on a five-point ordinal scale (0-4, 0= unable, 1= wheelchair, 2="assisted, 3= supervised, 4= independent). An overall score was calculated. The range of scale was 0 to 76.
  measure: Outdoor walking assessment
  time frame: 15 minutes
  description: Participants will walk 400 meters at their comfortable speed on the street. A 402-meter walkway will be used for outdoor walking test. In order to allow the participants to have enough distance to accelerate and decelerate, only the time taken the middle 400 meters will be recorded by a stopwatch. The outcome measure will be walking speed (m/s).
  arm group label: combined group
  arm group type: Experimental
  description: The combined group will undertake progressive treadmill walking speed while performing a cognitive task with rhythmic auditory cueing.
  arm group label: cognitive group
  arm group type: Active Comparator
  description: The cognitive group will receive cognitive training while walking on the treadmill.
  arm group label: rhythmic group
  arm group type: Active Comparator
  description: The rhythmic group will hear rhythmic auditory stimulation while treadmill walking.
  arm group label: treadmill group
  arm group type: Active Comparator
  description: The treadmill group will train only in progressive treadmill walking.
  intervention type: Device
  intervention name: Combined group
  description: The combined group will undertake progressive treadmill walking speed while performing a cognitive task with rhythmic auditory cueing for 30 minutes per session, 3 times a week for 4 weeks.
  arm group label: combined group
  intervention type: Device
  intervention name: Cognitive group
  description: The cognitive group will receive cognitive training while treadmill walking with a progressive speed for 30 minutes per session, 3 times a week for 4 weeks .
  arm group label: cognitive group
  intervention type: Device
  intervention name: Rhythmic group
  description: The rhythmic group will hear rhythmic auditory stimulation while treadmill walking for 30 minutes per session, 3 times a week for 4 weeks.
  arm group label: rhythmic group
  intervention type: Device
  intervention name: Treadmill group
  description: The treadmill group will train only in progressive treadmill walking for 30 minutes per session, 3 times a week for 4 weeks.
  arm group label: treadmill group
  criteria: 
  gender: All
  minimum age: 20 Years
  maximum age: 85 Years
  healthy volunteers: No
  last name: Li-Ling Chuang, Ph.D.
  role: Principal Investigator
  affiliation: Chang Gung University
  last name: Li-Ling Chuang, Ph.D.
  phone: 886-3-2118800
  phone ext: 3177
  email: lchunag@gap.cgu.edu.tw
  last name: Li-Ling Chuang, Ph.D.
  phone: 886-3-2118800
  phone ext: 3177
  email: lchuang@mail.cgu.edu.tw
  facility: 
  contact: 
  country: Taiwan
  responsible party type: Principal Investigator
  investigator affiliation: Chang Gung University
  investigator full name: Li-Ling Chuang
  investigator title: Associated Professor
  mesh term: Stroke
  sharing ipd: No