xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT05996861</url>
    </required_header>
    <id_info>
      <org_study_id>842</org_study_id>
      <nct_id>NCT05996861</nct_id>
    </id_info>
    <brief_title>Protocol For Sleep for Critically Ill Patients</brief_title>
    <official_title>Multidisciplinary Protocol for Best Pracrice in Sleep for Critically Ill Patients</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Hospital Moinhos de Vento</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Hospital Moinhos de Vento</source>
    <oversight_info>
      <has_dmc>No</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        Sleep is essential for health and well-being. The quality of sleep impacts physical and&#xD;
        cognitive aspects, including memory, immune system, and neuroendocrine function, with&#xD;
        abnormalities associated with cardiovascular changes, neuropsychiatric disorders, and&#xD;
        mortality. Additionally, sleep disorders are related to an increased incidence of delirium in&#xD;
        Intensive Care Units (ICUs). Routines to control environmental factors in ICUs seem to have&#xD;
        an impact on reducing the incidence of acute brain dysfunction - delirium - and could help&#xD;
        prevent sleep disturbances in critically ill patients. This study aims to demonstrate an&#xD;
        improvement in sleep quality in critically ill patients through the reduction of the&#xD;
        Richards-Campbell Sleep Questionnaire score and propose a package of measures to improve&#xD;
        sleep practices in ICU-admitted patients.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        Detailed description:&#xD;
  &#xD;
        Critically ill patients are particularly vulnerable to sleep disorders. In the context of&#xD;
        critical illness and ICU admission, there is an intersection of factors contributing to this&#xD;
        situation: pre-existing health conditions, severe acute illness, sleep-altering treatments&#xD;
        (sedatives, analgesics, mechanical ventilation), psychiatric disorders, and the physical&#xD;
        environment. In addition to the impact during hospitalization, the literature points to a&#xD;
        long-term reduction in quality of life due to sleep disturbance. Recent studies following up&#xD;
        on patients after ICU discharge reveal high rates of sleep disorders up to 6 months after&#xD;
        hospital discharge - related or unrelated to new psychiatric disorders and even cognitive&#xD;
        changes. Furthermore, sleep disorders are associated with an increased incidence of delirium&#xD;
        in ICUs, which refers to altered consciousness and cognition in patients admitted to the&#xD;
        intensive care environment, which are associated with worsened patient outcomes such as&#xD;
        increased hospital stay and consequently the risk of fatal complications. The prevalence of&#xD;
        delirium is around 70%, with an incidence of 89%. Delirium assessment in ICUs is usually&#xD;
        performed daily.&#xD;
  &#xD;
        In order to improve the sleep quality of this population, there are modifiable factors,&#xD;
        whether environmental (lighting, noise, general care), physiological (medications,&#xD;
        ventilatory parameter adjustments), or psychological (anxiety, pain, absence of family&#xD;
        members). Routines to control environmental factors in ICUs seem to have an impact on&#xD;
        reducing the incidence of acute brain dysfunction - delirium - and could help prevent sleep&#xD;
        disturbances in critically ill patients. These measures include dimming or reducing corridor&#xD;
        lights at night, grouping (when possible) care activities at appropriate times, raising&#xD;
        curtains, and encouraging mobilization during daytime shifts. For non-delirious patients, the&#xD;
        use of earplugs and eye masks is also recommended.&#xD;
  &#xD;
        Therefore, the investigators have developed this research project with the aim of evaluating&#xD;
        the implementation of a multifaceted and multidisciplinary protocol to promote an improvement&#xD;
        in sleep quality in critically ill patients.&#xD;
  &#xD;
        The SPIRIT Protocol is a summary of recommendations for clinical trials, which was used as a&#xD;
        support in this study. This is a multicenter clinical trial with a quasi-experimental design.&#xD;
  &#xD;
        The first step consists of assessing the sleep quality in sequential patients admitted to the&#xD;
        ICU and characterizing the disruptive elements.&#xD;
  &#xD;
        After this period, the second step will involve sensitizing and training the&#xD;
        multidisciplinary team about the importance of sleep for critically ill patients and&#xD;
        providing training for the implementation of a multifaceted protocol of interventions to&#xD;
        promote sleep quality improvement.&#xD;
  &#xD;
        Once the multidisciplinary protocol is implemented, the sleep quality of the patients and the&#xD;
        clinical impact of this protocol will be reevaluated.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Recruiting</overall_status>
    <start_date type="Actual">March 20, 2023</start_date>
    <completion_date type="Anticipated">June 1, 2024</completion_date>
    <primary_completion_date type="Anticipated">November 30, 2023</primary_completion_date>
    <study_type>Observational</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <observational_model>Cohort</observational_model>
      <time_perspective>Prospective</time_perspective>
    </study_design_info>
    <primary_outcome>
      <measure>Change in the Richards-Campbell Sleep Quality Score</measure>
      <time_frame>before and one month after implementation of the sleep protocol</time_frame>
      <description>To demonstrate a better sleep quality in critical patients</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Change in the Sleep in the ICU Questionnaire</measure>
      <time_frame>before and one month after implementation of the sleep protocol</time_frame>
      <description>Characterization of the perception of factors influencing sleep in critically ill patients</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change in the Confusion Assessment Method for the ICU</measure>
      <time_frame>before and one month after implementation of the sleep protocol</time_frame>
      <description>To evaluate the incidence of delirium and its duration according to sleep quality;</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change in the Questionnaire on the patient's perception of sleep from the family member's point of view</measure>
      <time_frame>before and one month after implementation of the sleep protocol</time_frame>
      <description>To compare patient satisfaction at ICU discharge with family satisfaction</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change in the Questionnaire for the evaluation of the multidisciplinary team regarding prior knowledge of sleep protocol</measure>
      <time_frame>before implementation of the sleep protocol</time_frame>
      <description>To assess the knowledge of the multidisciplinary team regarding sleep in critically ill patients before the implementation of the multidisciplinary protocol</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change in the Questionnaire for assessing and perceiving patients' sleep from the point of view of the care team</measure>
      <time_frame>one month after implementation of the sleep protocol</time_frame>
      <description>To assess the perception of the multidisciplinary team regarding the sleep quality of hospitalized patients after the implementation of the multidisciplinary protocol</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change in the Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale.</measure>
      <time_frame>at three and six months after hospital discharge</time_frame>
      <description>To evaluate the sleep quality of surviving patients of critical illnesses at ICU discharge</description>
    </secondary_outcome>
    <number_of_groups>2</number_of_groups>
    <enrollment type="Anticipated">100</enrollment>
    <condition>Sleep Disorders</condition>
    <arm_group>
      <arm_group_label>Pre-sleep protocol group</arm_group_label>
      <description>Patients with inclusion criteria assessed before the implementation of the sleep protocol.</description>
    </arm_group>
    <arm_group>
      <arm_group_label>Post-sleep protocol group</arm_group_label>
      <description>Patients with inclusion criteria after the implementation of the sleep protocol.</description>
    </arm_group>
    <intervention>
      <intervention_type>Behavioral</intervention_type>
      <intervention_name>ICU sleep protocol</intervention_name>
      <description>Adjusting sound intensity, as well as reducing noise: efforts will be made to minimize staff conversation volume during the night.&#xD;
  Earplugs will be offered, along with the provision of eye masks for lucid patients, and thermal comfort adjustments will be made, such as providing blankets and/or adjusting room temperature.&#xD;
  Dimming of lights starting from 10 PM. Reduced circulation of external services between 11 PM and 6 AM, and rationalization of sample collections and/or patient transfers between beds during the 11 PM to 6 AM interval.&#xD;
  Optimization of analgesics for better pain control; optimization of medication use during wakefulness when clinically feasible; adjustment of intervals for capillary blood glucose measurement; maintaining and/or resuming the use of chronic sleep medications. If the patient has been unable to sleep, a hypnotic medication will be offered.&#xD;
  Other considerations include suggesting ventilatory support measures for selected patients.</description>
      <arm_group_label>Post-sleep protocol group</arm_group_label>
    </intervention>
    <eligibility>
      <study_pop>
        <textblock>
          Adult patients admitted to the intensive care unit with a minimum stay of two nights&#xD;
        </textblock>
      </study_pop>
      <sampling_method>Non-Probability Sample</sampling_method>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Adult patients (18 years or older);&#xD;
  &#xD;
            -  Have spent at least two nights in the ICU;&#xD;
  &#xD;
            -  Neuropsychiatric conditions to respond to the sleep questionnaire Informed consent -&#xD;
               authorization through the ICF (Informed Consent Form).&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Neuropsychiatric conditions that prevent responding to the questionnaire, such as&#xD;
               patients with dementia, severe sequelae of cerebrovascular disease, inability to&#xD;
               understand and/or communicate, severe encephalopathy, deep sedation, acute brain&#xD;
               dysfunction and/or delirium, visual and/or auditory acuity impairments that prevent&#xD;
               responding to the questionnaire, active alcoholism, active illicit drug use, severe&#xD;
               withdrawal symptoms;&#xD;
  &#xD;
            -  Patients with deep sedation that does not allow interaction with the evaluator;&#xD;
  &#xD;
            -  Moribund patients;&#xD;
  &#xD;
            -  Refusal to participate in the study.&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>N/A</maximum_age>
      <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Laura Drehmer</last_name>
      <role>Principal Investigator</role>
      <affiliation>Vale dos Sinos Hospital</affiliation>
    </overall_official>
    <overall_official>
      <last_name>Felippe Dexheimer</last_name>
      <role>Study Director</role>
      <affiliation>Moinhos de Vento Hospital</affiliation>
    </overall_official>
    <overall_official>
      <last_name>Cassiano Teixeira</last_name>
      <role>Study Director</role>
      <affiliation>Moinhos de Vento Hospital</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Laura Drehmer</last_name>
      <phone>5551999886722</phone>
      <email>laura.drehmer@gmail.com</email>
    </overall_contact>
    <overall_contact_backup>
      <last_name>Felippe Dexheimer</last_name>
      <phone>555191195508</phone>
    </overall_contact_backup>
    <location>
      <facility>
        <name>Unimed Vale dos Sinos Hospital</name>
        <address>
          <city>Novo Hamburgo</city>
          <state>Rio Grande Do Sul</state>
          <country>Brazil</country>
        </address>
      </facility>
      <status>Recruiting</status>
    </location>
    <location>
      <facility>
        <name>Moinhos de Vento Hospital</name>
        <address>
          <city>Porto Alegre</city>
          <state>Rio Grande Do Sul</state>
          <country>Brazil</country>
        </address>
      </facility>
      <status>Recruiting</status>
    </location>
    <location_countries>
      <country>Brazil</country>
    </location_countries>
    <link>
      <url>http://www.spirit-statement.org/spirit-statement/</url>
      <description>SPIRIT 2013 Checklist</description>
    </link>
    <reference>
      <citation>Altman MT, Knauert MP, Pisani MA. Sleep Disturbance after Hospitalization and Critical Illness: A Systematic Review. Ann Am Thorac Soc. 2017 Sep;14(9):1457-1468. doi: 10.1513/AnnalsATS.201702-148SR.</citation>
      <PMID>28644698</PMID>
    </reference>
    <reference>
      <citation>Beltrami FG, John AB, de Macedo BR, Correa Junior V, Nguyen XL, Pichereau C, Maury E, Fleury B, Gus M, Fagondes SC. A multi-intervention protocol to improve sleep quality in a coronary care unit. Eur J Cardiovasc Nurs. 2022 Jun 30;21(5):464-472. doi: 10.1093/eurjcn/zvab099.</citation>
      <PMID>34935040</PMID>
    </reference>
    <reference>
      <citation>Ritmala-Castren M, Virtanen I, Vahlberg T, Leivo S, Kaukonen KM, Leino-Kilpi H. Evaluation of patients' sleep by nurses in an ICU. J Clin Nurs. 2016 Jun;25(11-12):1606-13. doi: 10.1111/jocn.13148. Epub 2016 Mar 18.</citation>
      <PMID>26991592</PMID>
    </reference>
    <reference>
      <citation>Ebben MR, Spielman AJ. Non-pharmacological treatments for insomnia. J Behav Med. 2009 Jun;32(3):244-54. doi: 10.1007/s10865-008-9198-8. Epub 2009 Jan 24.</citation>
      <PMID>19169804</PMID>
    </reference>
    <reference>
      <citation>Mori S, Takeda JR, Carrara FS, Cohrs CR, Zanei SS, Whitaker IY. Incidence and factors related to delirium in an intensive care unit. Rev Esc Enferm USP. 2016 Jul-Aug;50(4):587-593. doi: 10.1590/S0080-623420160000500007. English, Portuguese.</citation>
      <PMID>27680043</PMID>
    </reference>
    <reference>
      <citation>Richards KC, Wang YY, Jun J, Ye L. A Systematic Review of Sleep Measurement in Critically Ill Patients. Front Neurol. 2020 Nov 6;11:542529. doi: 10.3389/fneur.2020.542529. eCollection 2020.</citation>
      <PMID>33240191</PMID>
    </reference>
    <reference>
      <citation>Telias I, Wilcox ME. Sleep and Circadian Rhythm in Critical Illness. Crit Care. 2019 Mar 9;23(1):82. doi: 10.1186/s13054-019-2366-0.</citation>
      <PMID>30850003</PMID>
    </reference>
    <results_reference>
      <citation>Li SY, Wang TJ, Vivienne Wu SF, Liang SY, Tung HH. Efficacy of controlling night-time noise and activities to improve patients' sleep quality in a surgical intensive care unit. J Clin Nurs. 2011 Feb;20(3-4):396-407. doi: 10.1111/j.1365-2702.2010.03507.x.</citation>
      <PMID>21219521</PMID>
    </results_reference>
    <verification_date>August 2023</verification_date>
    <study_first_submitted>July 10, 2023</study_first_submitted>
    <study_first_submitted_qc>August 9, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 18, 2023</study_first_posted>
    <last_update_submitted>August 9, 2023</last_update_submitted>
    <last_update_submitted_qc>August 9, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">August 18, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Principal Investigator</responsible_party_type>
      <investigator_affiliation>Hospital Moinhos de Vento</investigator_affiliation>
      <investigator_full_name>Laura Drehmer</investigator_full_name>
      <investigator_title>Principal investigator</investigator_title>
    </responsible_party>
    <keyword>Sleep</keyword>
    <keyword>ICU</keyword>
    <keyword>Delirium</keyword>
    <keyword>Multidisciplinary Team</keyword>
    <keyword>Sleep Protocol</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Sleep Wake Disorders</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <provided_document_section>
      <provided_document>
        <document_type>Statistical Analysis Plan</document_type>
        <document_has_protocol>No</document_has_protocol>
        <document_has_icf>No</document_has_icf>
        <document_has_sap>Yes</document_has_sap>
        <document_date>February 8, 2023</document_date>
        <document_url>https://ClinicalTrials.gov/ProvidedDocs/61/NCT05996861/SAP_000.pdf</document_url>
      </provided_document>
      <provided_document>
        <document_type>Informed Consent Form</document_type>
        <document_has_protocol>No</document_has_protocol>
        <document_has_icf>Yes</document_has_icf>
        <document_has_sap>No</document_has_sap>
        <document_date>February 8, 2023</document_date>
        <document_url>https://ClinicalTrials.gov/ProvidedDocs/61/NCT05996861/ICF_001.pdf</document_url>
      </provided_document>
    </provided_document_section>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT05996861
  org study id: 842
  nct id: NCT05996861
  lead sponsor: 
  has dmc: No
  is fda regulated drug: No
  is fda regulated device: No
  Sleep is essential for health and well-being. The quality of sleep impacts physical and
        cognitive aspects, including memory, immune system, and neuroendocrine function, with
        abnormalities associated with cardiovascular changes, neuropsychiatric disorders, and
        mortality. Additionally, sleep disorders are related to an increased incidence of delirium in
        Intensive Care Units (ICUs). Routines to control environmental factors in ICUs seem to have
        an impact on reducing the incidence of acute brain dysfunction - delirium - and could help
        prevent sleep disturbances in critically ill patients. This study aims to demonstrate an
        improvement in sleep quality in critically ill patients through the reduction of the
        Richards-Campbell Sleep Questionnaire score and propose a package of measures to improve
        sleep practices in ICU-admitted patients.
  Detailed description:
  
        Critically ill patients are particularly vulnerable to sleep disorders. In the context of
        critical illness and ICU admission, there is an intersection of factors contributing to this
        situation: pre-existing health conditions, severe acute illness, sleep-altering treatments
        (sedatives, analgesics, mechanical ventilation), psychiatric disorders, and the physical
        environment. In addition to the impact during hospitalization, the literature points to a
        long-term reduction in quality of life due to sleep disturbance. Recent studies following up
        on patients after ICU discharge reveal high rates of sleep disorders up to 6 months after
        hospital discharge - related or unrelated to new psychiatric disorders and even cognitive
        changes. Furthermore, sleep disorders are associated with an increased incidence of delirium
        in ICUs, which refers to altered consciousness and cognition in patients admitted to the
        intensive care environment, which are associated with worsened patient outcomes such as
        increased hospital stay and consequently the risk of fatal complications. The prevalence of
        delirium is around 70%, with an incidence of 89%. Delirium assessment in ICUs is usually
        performed daily.
  
        In order to improve the sleep quality of this population, there are modifiable factors,
        whether environmental (lighting, noise, general care), physiological (medications,
        ventilatory parameter adjustments), or psychological (anxiety, pain, absence of family
        members). Routines to control environmental factors in ICUs seem to have an impact on
        reducing the incidence of acute brain dysfunction - delirium - and could help prevent sleep
        disturbances in critically ill patients. These measures include dimming or reducing corridor
        lights at night, grouping (when possible) care activities at appropriate times, raising
        curtains, and encouraging mobilization during daytime shifts. For non-delirious patients, the
        use of earplugs and eye masks is also recommended.
  
        Therefore, the investigators have developed this research project with the aim of evaluating
        the implementation of a multifaceted and multidisciplinary protocol to promote an improvement
        in sleep quality in critically ill patients.
  
        The SPIRIT Protocol is a summary of recommendations for clinical trials, which was used as a
        support in this study. This is a multicenter clinical trial with a quasi-experimental design.
  
        The first step consists of assessing the sleep quality in sequential patients admitted to the
        ICU and characterizing the disruptive elements.
  
        After this period, the second step will involve sensitizing and training the
        multidisciplinary team about the importance of sleep for critically ill patients and
        providing training for the implementation of a multifaceted protocol of interventions to
        promote sleep quality improvement.
  
        Once the multidisciplinary protocol is implemented, the sleep quality of the patients and the
        clinical impact of this protocol will be reevaluated.
  observational model: Cohort
  time perspective: Prospective
  measure: Change in the Richards-Campbell Sleep Quality Score
  time frame: before and one month after implementation of the sleep protocol
  description: To demonstrate a better sleep quality in critical patients
  measure: Change in the Sleep in the ICU Questionnaire
  time frame: before and one month after implementation of the sleep protocol
  description: Characterization of the perception of factors influencing sleep in critically ill patients
  measure: Change in the Confusion Assessment Method for the ICU
  time frame: before and one month after implementation of the sleep protocol
  description: To evaluate the incidence of delirium and its duration according to sleep quality;
  measure: Change in the Questionnaire on the patient's perception of sleep from the family member's point of view
  time frame: before and one month after implementation of the sleep protocol
  description: To compare patient satisfaction at ICU discharge with family satisfaction
  measure: Change in the Questionnaire for the evaluation of the multidisciplinary team regarding prior knowledge of sleep protocol
  time frame: before implementation of the sleep protocol
  description: To assess the knowledge of the multidisciplinary team regarding sleep in critically ill patients before the implementation of the multidisciplinary protocol
  measure: Change in the Questionnaire for assessing and perceiving patients' sleep from the point of view of the care team
  time frame: one month after implementation of the sleep protocol
  description: To assess the perception of the multidisciplinary team regarding the sleep quality of hospitalized patients after the implementation of the multidisciplinary protocol
  measure: Change in the Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale.
  time frame: at three and six months after hospital discharge
  description: To evaluate the sleep quality of surviving patients of critical illnesses at ICU discharge
  arm group label: Pre-sleep protocol group
  description: Patients with inclusion criteria assessed before the implementation of the sleep protocol.
  arm group label: Post-sleep protocol group
  description: Patients with inclusion criteria after the implementation of the sleep protocol.
  intervention type: Behavioral
  intervention name: ICU sleep protocol
  description: Adjusting sound intensity, as well as reducing noise: efforts will be made to minimize staff conversation volume during the night.
  Earplugs will be offered, along with the provision of eye masks for lucid patients, and thermal comfort adjustments will be made, such as providing blankets and/or adjusting room temperature.
  Dimming of lights starting from 10 PM. Reduced circulation of external services between 11 PM and 6 AM, and rationalization of sample collections and/or patient transfers between beds during the 11 PM to 6 AM interval.
  Optimization of analgesics for better pain control; optimization of medication use during wakefulness when clinically feasible; adjustment of intervals for capillary blood glucose measurement; maintaining and/or resuming the use of chronic sleep medications. If the patient has been unable to sleep, a hypnotic medication will be offered.
  Other considerations include suggesting ventilatory support measures for selected patients.
  arm group label: Post-sleep protocol group
  study pop: 
  sampling method: Non-Probability Sample
  criteria: 
  gender: All
  minimum age: 18 Years
  maximum age: N/A
  healthy volunteers: Accepts Healthy Volunteers
  last name: Laura Drehmer
  role: Principal Investigator
  affiliation: Vale dos Sinos Hospital
  last name: Felippe Dexheimer
  role: Study Director
  affiliation: Moinhos de Vento Hospital
  last name: Cassiano Teixeira
  role: Study Director
  affiliation: Moinhos de Vento Hospital
  last name: Laura Drehmer
  phone: 5551999886722
  email: laura.drehmer@gmail.com
  last name: Felippe Dexheimer
  phone: 555191195508
  facility: 
  status: Recruiting
  facility: 
  status: Recruiting
  country: Brazil
  url: http://www.spirit-statement.org/spirit-statement/
  description: SPIRIT 2013 Checklist
  citation: Altman MT, Knauert MP, Pisani MA. Sleep Disturbance after Hospitalization and Critical Illness: A Systematic Review. Ann Am Thorac Soc. 2017 Sep;14(9):1457-1468. doi: 10.1513/AnnalsATS.201702-148SR.
  PMID: 28644698
  citation: Beltrami FG, John AB, de Macedo BR, Correa Junior V, Nguyen XL, Pichereau C, Maury E, Fleury B, Gus M, Fagondes SC. A multi-intervention protocol to improve sleep quality in a coronary care unit. Eur J Cardiovasc Nurs. 2022 Jun 30;21(5):464-472. doi: 10.1093/eurjcn/zvab099.
  PMID: 34935040
  citation: Ritmala-Castren M, Virtanen I, Vahlberg T, Leivo S, Kaukonen KM, Leino-Kilpi H. Evaluation of patients' sleep by nurses in an ICU. J Clin Nurs. 2016 Jun;25(11-12):1606-13. doi: 10.1111/jocn.13148. Epub 2016 Mar 18.
  PMID: 26991592
  citation: Ebben MR, Spielman AJ. Non-pharmacological treatments for insomnia. J Behav Med. 2009 Jun;32(3):244-54. doi: 10.1007/s10865-008-9198-8. Epub 2009 Jan 24.
  PMID: 19169804
  citation: Mori S, Takeda JR, Carrara FS, Cohrs CR, Zanei SS, Whitaker IY. Incidence and factors related to delirium in an intensive care unit. Rev Esc Enferm USP. 2016 Jul-Aug;50(4):587-593. doi: 10.1590/S0080-623420160000500007. English, Portuguese.
  PMID: 27680043
  citation: Richards KC, Wang YY, Jun J, Ye L. A Systematic Review of Sleep Measurement in Critically Ill Patients. Front Neurol. 2020 Nov 6;11:542529. doi: 10.3389/fneur.2020.542529. eCollection 2020.
  PMID: 33240191
  citation: Telias I, Wilcox ME. Sleep and Circadian Rhythm in Critical Illness. Crit Care. 2019 Mar 9;23(1):82. doi: 10.1186/s13054-019-2366-0.
  PMID: 30850003
  citation: Li SY, Wang TJ, Vivienne Wu SF, Liang SY, Tung HH. Efficacy of controlling night-time noise and activities to improve patients' sleep quality in a surgical intensive care unit. J Clin Nurs. 2011 Feb;20(3-4):396-407. doi: 10.1111/j.1365-2702.2010.03507.x.
  PMID: 21219521
  responsible party type: Principal Investigator
  investigator affiliation: Hospital Moinhos de Vento
  investigator full name: Laura Drehmer
  investigator title: Principal investigator
  mesh term: Sleep Wake Disorders
  sharing ipd: No
  provided document: 
  provided document: 