xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT06024980</url>
    </required_header>
    <id_info>
      <org_study_id>2022-59</org_study_id>
      <nct_id>NCT06024980</nct_id>
    </id_info>
    <brief_title>Using the Subglottic Pressure to Predict the Dysphagia After Partial Laryngectomy</brief_title>
    <acronym>SPPDPL</acronym>
    <official_title>Department of Otolaryngology Head Neck Surg</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Guangdong Provincial People's Hospital</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Guangdong Provincial People's Hospital</source>
    <oversight_info>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        Recruited patients are divided into two arms depending on laryngeal carcinoma's T1 and T2&#xD;
        stages. Two interventions were undergone, including transoral endoscopic laser cordectomy and&#xD;
        open partial horizontal laryngectomy (OPHL). During the pre-and post-operative time, patients&#xD;
        performed measurements of swallowing function, including direct subglottic pressure, Eating&#xD;
        Assessment Tool-10(EAT-10) questionnaire, swallowing ability to different textures, and&#xD;
        fiberoptic evaluation of swallowing(FEES). Patients undergo subglottic pressure measurement&#xD;
        and swallowing function evaluation three times: 3-7 days, two months, and six months after&#xD;
        surgery. Patients also performed measurement voice acoustic analysis and subjective&#xD;
        assessment one-day pre-operation and six months post-operation.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        There were swallowing disorders after partial laryngectomy in most patients with laryngeal&#xD;
        carcinoma. At least these patients need several months to recover. Few people required&#xD;
        surgery of total laryngectomy to maintain normal swallowing function. The swallowing training&#xD;
        cannot acquire a valid swallowing function and take the risk of aspiration pneumonia. Factors&#xD;
        that influenced the swallowing function recovery, for example, the time of nasogastric&#xD;
        feeding and tracheostomy tube removal, were affected by age and diabetes.&#xD;
  &#xD;
        On the other hand, the pharynx size of a CT scan can predict the recovery of swallowing&#xD;
        function after laryngectomy. But those are not directly related to swallowing motion,&#xD;
        although they are predictors of dysphagia. The investigators will perform the study with&#xD;
        swallowing function measures to find predictors relative to swallowing function and evaluate&#xD;
        dysphagia's recovery early.&#xD;
  &#xD;
        Subglottic pressure is a protective factor that can reduce aspiration risk. This research&#xD;
        will measure the subglottic pressure after laryngectomy and predict or monitor swallowing&#xD;
        disorders. Specific objectives were to verify the effect of laryngectomy on subglottic&#xD;
        pressure.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Recruiting</overall_status>
    <start_date type="Actual">January 3, 2023</start_date>
    <completion_date type="Anticipated">December 1, 2025</completion_date>
    <primary_completion_date type="Anticipated">November 1, 2025</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>Non-Randomized</allocation>
      <intervention_model>Factorial Assignment</intervention_model>
      <primary_purpose>Prevention</primary_purpose>
      <masking>Double (Investigator, Outcomes Assessor)</masking>
    </study_design_info>
    <primary_outcome>
      <measure>Fiberoptic laryngoscope evaluation of swallowing</measure>
      <time_frame>Pre-operation, one week post-operation, two months post-operation, six months post-operation</time_frame>
      <description>The patient, in a sitting position, had to swallow liquid. The tip of a flexible endoscope was positioned beyond the soft palate, and the pharyngeal phase of swallowing was studied, recording videos and images for further analysis. In particular, according to the severity scale, the scores ranged from 1 point (no materials entered the airway) to 8 points (the material penetrated below the vocal cords, but no effort was made to eject the material), representing the severity of risk for penetration</description>
    </primary_outcome>
    <primary_outcome>
      <measure>direct subglottic pressure</measure>
      <time_frame>At one day before surgery, one week after surgery, two months after surgery, six months after surgery</time_frame>
      <description>Subglottic pressure was measured while swallowing a thinned solution with and without airflow delivery through the subglottic puncture needle. The unit of subglottic pressure is cmH20.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>EAT-10 questionnaire</measure>
      <time_frame>At one day before surgery, two months after surgery, six months after surgery</time_frame>
      <description>The EAT-10 questionnaire consists of a 10-item questionnaire with a maximum total score of 40 points. All items are rated on a 5-point scale in which 0 indicates no problem, and 4 indicates a severe problem in swallowing function. An EAT-10 score of over 3 is abnormal and indicates a higher self-perception of the presence of dysphagia.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Swallowing ability to four different textures</measure>
      <time_frame>At one day before surgery, one week after surgery, two months after surgery, six months after surgery</time_frame>
      <description>An early 5-point scoring system (score one corresponding to the early postoperative assessment) was applied to each patient depending on his ability to swallow one to four different textures (liquid, semi-liquid, semi-solid, and solid). A score of 0 is poor (no power to swallow), while a score of 4 is good.</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Voice acoustic analysis</measure>
      <time_frame>At one day before surgery, six months after surgery</time_frame>
      <description>Every participant was asked to phonate a sustained vowel /a/ at a habitual comfortable pitch and intensity for voice pitch, quality assessments, and habitual vocal intensity. The recordings were made in a quiet clinical room. The participant sat in front of a microphone positioned approximately 10cm from the left corner of the mouth. The voice signal coupled with Roland's Audio interface with a sampling rate of 44k-Hz and 16-bit accuracy. The signal was stored in a computer system after collecting sustained vowels. The voice signals were analyzed using speech analysis software. The stable phase of the voice sample was extracted for analysis. The 3,000-msec sample was analyzed for acoustic parameters. The voice acoustic parameters include F0 (fundamental frequency) in Hertz(Hz), percentage of jitter(%), percentage of shimmer(%), Harmonic to noise ratio(HNR), and intensity in decibels(dB).</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>The time in weeks of nasogastric feeding</measure>
      <time_frame>At two months after surgery, six months after surgery</time_frame>
      <description>The duration of surgery to oral feeding after withdrawing naso tube.</description>
    </secondary_outcome>
    <number_of_arms>2</number_of_arms>
    <enrollment type="Anticipated">50</enrollment>
    <condition>Laryngeal Cancer</condition>
    <condition>Dysphagia</condition>
    <arm_group>
      <arm_group_label>Supraglottic and glottic T2 laryngeal carcinoma</arm_group_label>
      <arm_group_type>Active Comparator</arm_group_type>
      <description>The open partial horizontal laryngectomy was underwent in patients with supraglottic or glottic laryngeal carcinoma in T2</description>
    </arm_group>
    <arm_group>
      <arm_group_label>Supraglottic and glottic T1 laryngeal carcinoma</arm_group_label>
      <arm_group_type>Active Comparator</arm_group_type>
      <description>The transoral endoscopic laser cordectomy was underwent in patients with supraglottic or glottic laryngeal carcinoma in T1</description>
    </arm_group>
    <intervention>
      <intervention_type>Procedure</intervention_type>
      <intervention_name>Open partial horizontal laryngectomy(OPHL), Type I-III</intervention_name>
      <description>An open partial horizontal laryngectomy(OPHL) was performed for patients with T2 supraglottic and glottic carcinoma, according to the American Joint Committee on Cancer(AJCC) criteria. Type I OPHL: Entails the resection of the supraglottis, including the pre-epiglottic space and the upper half of the thyroid cartilage. Type II OPHL: Entails the resection of the entire thyroid cartilage, with the inferior limit represented by the upper edge of the cricoid ring. Type III OPHL: Entails the resection of the entire supraglottic, glottic, and part of the subglottic sites, sparing both or at least one functioning crico-arytenoid unit.</description>
      <arm_group_label>Supraglottic and glottic T2 laryngeal carcinoma</arm_group_label>
      <other_name>Type I OPHLs(formerly defined horizontal supraglottic laryngectomy), Type II (previously called supracricoid laryngectomy), and Type III (also named supratracheal laryngectomy).</other_name>
    </intervention>
    <intervention>
      <intervention_type>Procedure</intervention_type>
      <intervention_name>Transoral endoscopic laser cordectomy</intervention_name>
      <description>For patients with T1 glottic laryngeal carcinoma, according to the criteria of the American Joint Committee on Cancer(AJCC), transoral endoscopic CO2 laser(2-40Watts) cordectomy was performed. The classification comprises eight types of cordectomies:&#xD;
  A subepithelial cordectomy (type I) is a resection of the epithelium of the vocal fold.&#xD;
  A subligamental cordectomy (type II) is a resection of the epithelium, Reinke's space, and vocal ligament.&#xD;
  Transmuscular cordectomy (type III), which proceeds through the vocalis muscle.&#xD;
  Total cordectomy (type IV).&#xD;
  Extended cordectomy encompasses the contralateral vocal fold and the anterior commissure (type Va).&#xD;
  Extended cordectomy, which includes the arytenoid (type Vb).&#xD;
  Extended cordectomy, which encompasses the subglottis (type Vc).&#xD;
  Extended cordectomy, which consists of the ventricle (type Vd).</description>
      <arm_group_label>Supraglottic and glottic T1 laryngeal carcinoma</arm_group_label>
      <other_name>Transoral carbon dioxide(CO2) laser microsurgery</other_name>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Age: 18-80 years&#xD;
  &#xD;
            -  Surgical treatment by open partial horizontal laryngectomy type I or II and transoral&#xD;
               laser cordectomy for squamous cell carcinoma&#xD;
  &#xD;
            -  Availability of clinical data&#xD;
  &#xD;
            -  Validity of normal swallowing of thin liquids&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Presence of severe chronic obstructive pulmonary disease, severe heart disease, and&#xD;
               psychopathy or mental disease&#xD;
  &#xD;
            -  Surgery complications(such as sepsis, pharyngocutaneous fistula, surgical revision)&#xD;
  &#xD;
            -  Radiotherapy histology&#xD;
  &#xD;
            -  Swallowing disorder or trachea aspiration before surgery.&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>80 Years</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Xujiao Chen, Ms</last_name>
      <role>Principal Investigator</role>
      <affiliation>Guangdong Provicial People's Hospital（Guangdong Academy of Sciences), Southern Medical University</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Pingjiang Ge, M.D.</last_name>
      <phone>+8613751753465</phone>
      <email>gepingjiang@aliyun.com</email>
    </overall_contact>
    <location>
      <facility>
        <name>Guangdong Provincial People's hospital</name>
        <address>
          <city>Guangzhou</city>
          <state>Guangdong</state>
          <zip>510080</zip>
          <country>China</country>
        </address>
      </facility>
      <status>Recruiting</status>
      <contact>
        <last_name>Pingjiang Ge</last_name>
        <phone>+8613751753465</phone>
        <email>gepingjiang@aliyun.com</email>
      </contact>
    </location>
    <location_countries>
      <country>China</country>
    </location_countries>
    <reference>
      <citation>Bagwell K, Leder SB, Sasaki CT. Is partial laryngectomy safe forever? Am J Otolaryngol. 2015 May-Jun;36(3):437-41. doi: 10.1016/j.amjoto.2014.11.005. Epub 2014 Nov 20.</citation>
      <PMID>25595047</PMID>
    </reference>
    <reference>
      <citation>Freitas AS, Santos IC, Furia C, Dornelas R, Silva ACAE, Dias FL, Salles GF. Prevalence and associated factors of aspiration and severe dysphagia in asymptomatic patients in the late period after open partial laryngectomy: a videofluoroscopic evaluation. Eur Arch Otorhinolaryngol. 2022 Jul;279(7):3695-3703. doi: 10.1007/s00405-021-07231-4. Epub 2022 Jan 4.</citation>
      <PMID>34982204</PMID>
    </reference>
    <reference>
      <citation>Breunig C, Benter P, Seidl RO, Coordes A. Predictable swallowing function after open horizontal supraglottic partial laryngectomy. Auris Nasus Larynx. 2016 Dec;43(6):658-65. doi: 10.1016/j.anl.2016.01.003. Epub 2016 Feb 4.</citation>
      <PMID>26853312</PMID>
    </reference>
    <reference>
      <citation>Dawson C, Pracy P, Patterson J, Paleri V. Rehabilitation following open partial laryngeal surgery: key issues and recommendations from the UK evidence based meeting on laryngeal cancer. J Laryngol Otol. 2019 Mar;133(3):177-182. doi: 10.1017/S0022215119000483.</citation>
      <PMID>30983563</PMID>
    </reference>
    <reference>
      <citation>Clarett M, Andreu MF, Salvati IG, Donnianni MC, Montes GS, Rodriguez MG. [Effect of subglottic air insufflation on subglottic pressure during swallowing]. Med Intensiva. 2014 Apr;38(3):133-9. doi: 10.1016/j.medin.2013.01.003. Epub 2013 Mar 6. Spanish.</citation>
      <PMID>23473519</PMID>
    </reference>
    <reference>
      <citation>Alaskarov E, Ozturk O, Batioglu-Karaaltin A, Gulmez ZD, Erdur ZB, Inan HC. Functional Outcomes of the Hyaluronic Acid Injections in Patients Who Underwent Partial Laryngectomy. J Voice. 2022 May;36(3):417-422. doi: 10.1016/j.jvoice.2020.06.026. Epub 2020 Jul 22.</citation>
      <PMID>32712078</PMID>
    </reference>
    <reference>
      <citation>Fakhry N, Michel J, Giorgi R, Robert D, Lagier A, Santini L, Moreddu E, Puymerail L, Adalian P, Dessi P, Giovanni A. Analysis of swallowing after partial frontolateral laryngectomy with epiglottic reconstruction for glottic cancer. Eur Arch Otorhinolaryngol. 2014 Jul;271(7):2013-20. doi: 10.1007/s00405-013-2750-3. Epub 2013 Oct 8.</citation>
      <PMID>24100885</PMID>
    </reference>
    <verification_date>August 2023</verification_date>
    <study_first_submitted>August 21, 2023</study_first_submitted>
    <study_first_submitted_qc>August 29, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">September 6, 2023</study_first_posted>
    <last_update_submitted>September 8, 2023</last_update_submitted>
    <last_update_submitted_qc>September 8, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">September 13, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Sponsor</responsible_party_type>
    </responsible_party>
    <keyword>partial laryngectomy</keyword>
    <keyword>subglottic pressure</keyword>
    <keyword>laser</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Laryngeal Neoplasms</mesh_term>
      <mesh_term>Deglutition Disorders</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT06024980
  org study id: 2022-59
  nct id: NCT06024980
  lead sponsor: 
  is fda regulated drug: No
  is fda regulated device: No
  Recruited patients are divided into two arms depending on laryngeal carcinoma's T1 and T2
        stages. Two interventions were undergone, including transoral endoscopic laser cordectomy and
        open partial horizontal laryngectomy (OPHL). During the pre-and post-operative time, patients
        performed measurements of swallowing function, including direct subglottic pressure, Eating
        Assessment Tool-10(EAT-10) questionnaire, swallowing ability to different textures, and
        fiberoptic evaluation of swallowing(FEES). Patients undergo subglottic pressure measurement
        and swallowing function evaluation three times: 3-7 days, two months, and six months after
        surgery. Patients also performed measurement voice acoustic analysis and subjective
        assessment one-day pre-operation and six months post-operation.
  There were swallowing disorders after partial laryngectomy in most patients with laryngeal
        carcinoma. At least these patients need several months to recover. Few people required
        surgery of total laryngectomy to maintain normal swallowing function. The swallowing training
        cannot acquire a valid swallowing function and take the risk of aspiration pneumonia. Factors
        that influenced the swallowing function recovery, for example, the time of nasogastric
        feeding and tracheostomy tube removal, were affected by age and diabetes.
  
        On the other hand, the pharynx size of a CT scan can predict the recovery of swallowing
        function after laryngectomy. But those are not directly related to swallowing motion,
        although they are predictors of dysphagia. The investigators will perform the study with
        swallowing function measures to find predictors relative to swallowing function and evaluate
        dysphagia's recovery early.
  
        Subglottic pressure is a protective factor that can reduce aspiration risk. This research
        will measure the subglottic pressure after laryngectomy and predict or monitor swallowing
        disorders. Specific objectives were to verify the effect of laryngectomy on subglottic
        pressure.
  allocation: Non-Randomized
  intervention model: Factorial Assignment
  primary purpose: Prevention
  masking: Double (Investigator, Outcomes Assessor)
  measure: Fiberoptic laryngoscope evaluation of swallowing
  time frame: Pre-operation, one week post-operation, two months post-operation, six months post-operation
  description: The patient, in a sitting position, had to swallow liquid. The tip of a flexible endoscope was positioned beyond the soft palate, and the pharyngeal phase of swallowing was studied, recording videos and images for further analysis. In particular, according to the severity scale, the scores ranged from 1 point (no materials entered the airway) to 8 points (the material penetrated below the vocal cords, but no effort was made to eject the material), representing the severity of risk for penetration
  measure: direct subglottic pressure
  time frame: At one day before surgery, one week after surgery, two months after surgery, six months after surgery
  description: Subglottic pressure was measured while swallowing a thinned solution with and without airflow delivery through the subglottic puncture needle. The unit of subglottic pressure is cmH20.
  measure: EAT-10 questionnaire
  time frame: At one day before surgery, two months after surgery, six months after surgery
  description: The EAT-10 questionnaire consists of a 10-item questionnaire with a maximum total score of 40 points. All items are rated on a 5-point scale in which 0 indicates no problem, and 4 indicates a severe problem in swallowing function. An EAT-10 score of over 3 is abnormal and indicates a higher self-perception of the presence of dysphagia.
  measure: Swallowing ability to four different textures
  time frame: At one day before surgery, one week after surgery, two months after surgery, six months after surgery
  description: An early 5-point scoring system (score one corresponding to the early postoperative assessment) was applied to each patient depending on his ability to swallow one to four different textures (liquid, semi-liquid, semi-solid, and solid). A score of 0 is poor (no power to swallow), while a score of 4 is good.
  measure: Voice acoustic analysis
  time frame: At one day before surgery, six months after surgery
  description: Every participant was asked to phonate a sustained vowel /a/ at a habitual comfortable pitch and intensity for voice pitch, quality assessments, and habitual vocal intensity. The recordings were made in a quiet clinical room. The participant sat in front of a microphone positioned approximately 10cm from the left corner of the mouth. The voice signal coupled with Roland's Audio interface with a sampling rate of 44k-Hz and 16-bit accuracy. The signal was stored in a computer system after collecting sustained vowels. The voice signals were analyzed using speech analysis software. The stable phase of the voice sample was extracted for analysis. The 3,000-msec sample was analyzed for acoustic parameters. The voice acoustic parameters include F0 (fundamental frequency) in Hertz(Hz), percentage of jitter(%), percentage of shimmer(%), Harmonic to noise ratio(HNR), and intensity in decibels(dB).
  measure: The time in weeks of nasogastric feeding
  time frame: At two months after surgery, six months after surgery
  description: The duration of surgery to oral feeding after withdrawing naso tube.
  arm group label: Supraglottic and glottic T2 laryngeal carcinoma
  arm group type: Active Comparator
  description: The open partial horizontal laryngectomy was underwent in patients with supraglottic or glottic laryngeal carcinoma in T2
  arm group label: Supraglottic and glottic T1 laryngeal carcinoma
  arm group type: Active Comparator
  description: The transoral endoscopic laser cordectomy was underwent in patients with supraglottic or glottic laryngeal carcinoma in T1
  intervention type: Procedure
  intervention name: Open partial horizontal laryngectomy(OPHL), Type I-III
  description: An open partial horizontal laryngectomy(OPHL) was performed for patients with T2 supraglottic and glottic carcinoma, according to the American Joint Committee on Cancer(AJCC) criteria. Type I OPHL: Entails the resection of the supraglottis, including the pre-epiglottic space and the upper half of the thyroid cartilage. Type II OPHL: Entails the resection of the entire thyroid cartilage, with the inferior limit represented by the upper edge of the cricoid ring. Type III OPHL: Entails the resection of the entire supraglottic, glottic, and part of the subglottic sites, sparing both or at least one functioning crico-arytenoid unit.
  arm group label: Supraglottic and glottic T2 laryngeal carcinoma
  other name: Type I OPHLs(formerly defined horizontal supraglottic laryngectomy), Type II (previously called supracricoid laryngectomy), and Type III (also named supratracheal laryngectomy).
  intervention type: Procedure
  intervention name: Transoral endoscopic laser cordectomy
  description: For patients with T1 glottic laryngeal carcinoma, according to the criteria of the American Joint Committee on Cancer(AJCC), transoral endoscopic CO2 laser(2-40Watts) cordectomy was performed. The classification comprises eight types of cordectomies:
  A subepithelial cordectomy (type I) is a resection of the epithelium of the vocal fold.
  A subligamental cordectomy (type II) is a resection of the epithelium, Reinke's space, and vocal ligament.
  Transmuscular cordectomy (type III), which proceeds through the vocalis muscle.
  Total cordectomy (type IV).
  Extended cordectomy encompasses the contralateral vocal fold and the anterior commissure (type Va).
  Extended cordectomy, which includes the arytenoid (type Vb).
  Extended cordectomy, which encompasses the subglottis (type Vc).
  Extended cordectomy, which consists of the ventricle (type Vd).
  arm group label: Supraglottic and glottic T1 laryngeal carcinoma
  other name: Transoral carbon dioxide(CO2) laser microsurgery
  criteria: 
  gender: All
  minimum age: 18 Years
  maximum age: 80 Years
  healthy volunteers: No
  last name: Xujiao Chen, Ms
  role: Principal Investigator
  affiliation: Guangdong Provicial People's Hospital（Guangdong Academy of Sciences), Southern Medical University
  last name: Pingjiang Ge, M.D.
  phone: +8613751753465
  email: gepingjiang@aliyun.com
  facility: 
  status: Recruiting
  contact: 
  country: China
  citation: Bagwell K, Leder SB, Sasaki CT. Is partial laryngectomy safe forever? Am J Otolaryngol. 2015 May-Jun;36(3):437-41. doi: 10.1016/j.amjoto.2014.11.005. Epub 2014 Nov 20.
  PMID: 25595047
  citation: Freitas AS, Santos IC, Furia C, Dornelas R, Silva ACAE, Dias FL, Salles GF. Prevalence and associated factors of aspiration and severe dysphagia in asymptomatic patients in the late period after open partial laryngectomy: a videofluoroscopic evaluation. Eur Arch Otorhinolaryngol. 2022 Jul;279(7):3695-3703. doi: 10.1007/s00405-021-07231-4. Epub 2022 Jan 4.
  PMID: 34982204
  citation: Breunig C, Benter P, Seidl RO, Coordes A. Predictable swallowing function after open horizontal supraglottic partial laryngectomy. Auris Nasus Larynx. 2016 Dec;43(6):658-65. doi: 10.1016/j.anl.2016.01.003. Epub 2016 Feb 4.
  PMID: 26853312
  citation: Dawson C, Pracy P, Patterson J, Paleri V. Rehabilitation following open partial laryngeal surgery: key issues and recommendations from the UK evidence based meeting on laryngeal cancer. J Laryngol Otol. 2019 Mar;133(3):177-182. doi: 10.1017/S0022215119000483.
  PMID: 30983563
  citation: Clarett M, Andreu MF, Salvati IG, Donnianni MC, Montes GS, Rodriguez MG. [Effect of subglottic air insufflation on subglottic pressure during swallowing]. Med Intensiva. 2014 Apr;38(3):133-9. doi: 10.1016/j.medin.2013.01.003. Epub 2013 Mar 6. Spanish.
  PMID: 23473519
  citation: Alaskarov E, Ozturk O, Batioglu-Karaaltin A, Gulmez ZD, Erdur ZB, Inan HC. Functional Outcomes of the Hyaluronic Acid Injections in Patients Who Underwent Partial Laryngectomy. J Voice. 2022 May;36(3):417-422. doi: 10.1016/j.jvoice.2020.06.026. Epub 2020 Jul 22.
  PMID: 32712078
  citation: Fakhry N, Michel J, Giorgi R, Robert D, Lagier A, Santini L, Moreddu E, Puymerail L, Adalian P, Dessi P, Giovanni A. Analysis of swallowing after partial frontolateral laryngectomy with epiglottic reconstruction for glottic cancer. Eur Arch Otorhinolaryngol. 2014 Jul;271(7):2013-20. doi: 10.1007/s00405-013-2750-3. Epub 2013 Oct 8.
  PMID: 24100885
  responsible party type: Sponsor
  mesh term: Laryngeal Neoplasms
  mesh term: Deglutition Disorders
  sharing ipd: No