xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT06018051</url>
    </required_header>
    <id_info>
      <org_study_id>GO 23/582</org_study_id>
      <nct_id>NCT06018051</nct_id>
    </id_info>
    <brief_title>&quot;Can Do&quot; Versus &quot;Do Do&quot; in Patients With Breast Cancer</brief_title>
    <official_title>Evaluation of the Concept &quot;Can Do&quot; Versus &quot;Do Do&quot; in Patients With Breast Cancer</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Hacettepe University</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Hacettepe University</source>
    <oversight_info>
      <has_dmc>No</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        Breast cancer occurs as a result of uncontrolled proliferation of cells in the breast tissue.&#xD;
        Breast cancer is the most common type of cancer among women worldwide and is an important&#xD;
        problem that threatens women's lives. The incidence rate has reached approximately 16 Breast&#xD;
        cancer treatment consists of local and systemic therapies. While local treatments include&#xD;
        surgery and radiotherapy, systemic treatments, which are administered in two different ways,&#xD;
        namely adjuvant and neoadjuvant systemic treatments, consist of chemotherapy, hormone therapy&#xD;
        and targeted biological therapies. Although the treatment options for breast cancer are&#xD;
        increasing day by day, there are many complications during and after treatment. These&#xD;
        complications negatively affect functionality and quality of life The 6-minute walk test&#xD;
        (6MWD) is a widely used test for indirect measurement of cardiorespiratory fitness in various&#xD;
        cancer populations. Studies have proven that the 6MWT is safe and feasible in breast cancer&#xD;
        patients. The concept of 'can do, do do' has recently emerged to describe impaired physical&#xD;
        functions in chronic obstructive pulmonary disease (COPD) and asthma. This concept&#xD;
        categorizes participants into four quadrants based on physical activity level and functional&#xD;
        capacity measurements and cut-off point. This concept has proven useful for measuring&#xD;
        physical function in both asthma and COPD. This concept may be useful in understanding&#xD;
        physical functioning in breast cancer patients. Therefore, The aim of this study is to apply&#xD;
        the concept of 'can do, do do' in breast cancer patients, to determine the quadrants&#xD;
        according to physical activity level and functional capacity measurements in breast cancer&#xD;
        patients, to investigate whether and to what extent there is a difference, whether and to&#xD;
        what extent there is a difference between demographic information, disease stages,&#xD;
        comorbidity level, clinical features, peripheral muscle strength, fatigue and quality of life&#xD;
        and upper extremity functionality according to quadrants.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        Breast cancer occurs as a result of uncontrolled proliferation of cells in the breast tissue.&#xD;
        Breast cancer is the most common type of cancer among women worldwide and is an important&#xD;
        problem that threatens women's lives. The incidence rate has reached approximately 16 Breast&#xD;
        cancer treatment consists of local and systemic therapies. While local treatments include&#xD;
        surgery and radiotherapy, systemic treatments, which are administered in two different ways,&#xD;
        namely adjuvant and neoadjuvant systemic treatments, consist of chemotherapy, hormone therapy&#xD;
        and targeted biological therapies. Although the treatment options for breast cancer are&#xD;
        increasing day by day, there are many complications during and after treatment. These&#xD;
        complications negatively affect functionality and quality of life.&#xD;
  &#xD;
        Thanks to the increasing treatment possibilities with the developing technology in recent&#xD;
        years, the majority of patients show good functional recovery after breast cancer. However,&#xD;
        it has been reported that treatments negatively affect the functional capacity of the upper&#xD;
        extremities, daily life, work and social activities and decrease the quality of life. Many&#xD;
        side effects are observed in patients after breast cancer treatment. Therefore, there are&#xD;
        various rehabilitation needs. Side effects vary from person to person. Therefore, the&#xD;
        rehabilitation program to be applied should be personalized. Commonly reported side effects&#xD;
        of the disease or treatments include pain, lymphedema, fatigue and depression. In addition,&#xD;
        psychosocial consequences and psychological distress, such as reduced health-related quality&#xD;
        of life and reduced social contacts, as well as difficulties in maintaining functional&#xD;
        activities and life roles, have been reported. As a result, breast cancer patients may have&#xD;
        physical, psychological, social and existential rehabilitation needs.&#xD;
  &#xD;
        Exercise is an effective non-pharmacologic treatment method in cancer patients. Exercise also&#xD;
        has therapeutic properties in cancer-related fatigue. Increased physical activity has been&#xD;
        reported to improve psychological recovery and physical well-being in cancer patients.&#xD;
        Aerobic exercise has been proven to reduce cancer-related fatigue as a result of studies. It&#xD;
        has also been reported that supervised exercise during chemotherapy or radiotherapy&#xD;
        treatments both increases the effectiveness of the treatment and reduces the side effects&#xD;
        that may occur. In addition, resistance exercises significantly reduce cancer-related&#xD;
        fatigue. There is evidence that there is a strong relationship between the risk of breast&#xD;
        cancer and physical activity level. Exercise training is an important physiotherapy and&#xD;
        rehabilitation approach in breast cancer survivors. According to randomized controlled trials&#xD;
        on the outcomes of exercise modalities in women with breast cancer, women who exercise have&#xD;
        improved survival rates. Physical and psychological conditions such as fatigue, pain,&#xD;
        anxiety, depression and decreased functional capacity reduce patients' quality of life.&#xD;
        Exercise interventions during or after treatment have been reported to improve&#xD;
        musculoskeletal performance, cardiorespiratory fitness, body awareness, and psychological&#xD;
        status in breast cancer. Previous studies have also reported that exercise training programs&#xD;
        to be applied during or after cancer treatment in cancer patients improve quality of life. It&#xD;
        has been reported that mind-body togetherness exercises such as aerobic, resistance,&#xD;
        stretching, yoga, and Tai Chi in breast cancer patients improve quality of life and general&#xD;
        and mental health, and have a positive effect on of the maximal oxygen uptake (VO2 max) , and&#xD;
        provide significant improvements in self-esteem and attitude towards life. In addition,&#xD;
        exercise training alleviates symptoms of depression and anxiety in breast cancer survivors.&#xD;
        In addition to reducing body mass index (BMI) and causing significant increases in lean mass,&#xD;
        exercise also increases muscle strength in the intervention groups. Furthermore, the serum&#xD;
        concentration of some physiological markers, such as insulin, insulin-like growth factor&#xD;
        (IGF-II) and insulin-like growth factor binding protein (IGFBP-1), is significantly reduced&#xD;
        after the exercise intervention. Physical activity has been shown to improve the symptom of&#xD;
        fatigue.&#xD;
  &#xD;
        The type, intensity, intensity and duration of the exercise to be applied differ from person&#xD;
        to person. Exercise intervention is safe both during and after systemic treatments.&#xD;
        Therefore, exercise intervention should be prescribed to breast cancer patients and they&#xD;
        should be encouraged to maintain their established exercise habits or adopt a correct type of&#xD;
        exercise.&#xD;
  &#xD;
        The most widely accepted exercise regimen for breast cancer patients is about 150 minutes of&#xD;
        moderate to vigorous intensity aerobic exercise per week. However, only 30% to 47% of breast&#xD;
        cancer survivors are reported to adhere to the recommended exercise programs. Furthermore,&#xD;
        aerobic exercise, strengthening exercises or body-mind exercises have a significant impact on&#xD;
        side effects after cancer treatments. Aerobic and resistance exercises reduce physical and&#xD;
        psychosocial problems associated with cancer and cancer treatment. Breast cancer survivors&#xD;
        are also recommended mindfulness, yoga or body-mind exercises to feel better and more&#xD;
        relaxed. Breathing exercises during physical activity are important for relaxation.&#xD;
  &#xD;
        The 6-minute walk test (6MWD) is a widely used test for indirect measurement of&#xD;
        cardiorespiratory fitness in various cancer populations. Studies have proven that the 6MWT is&#xD;
        safe and feasible in breast cancer patients. The concept of 'can do, do do' has recently&#xD;
        emerged to describe impaired physical functions in chronic obstructive pulmonary disease&#xD;
        (COPD) and asthma. This concept categorizes investigators into four quadrants based on&#xD;
        physical activity level and functional capacity measurements and cut-off point. This concept&#xD;
        has proven useful for measuring physical function in both asthma and COPD. This concept may&#xD;
        be useful in understanding physical functioning in breast cancer patients. Therefore, The aim&#xD;
        of this study is to apply the concept of 'can do, do do' in breast cancer patients, to&#xD;
        determine the quadrants according to physical activity level and functional capacity&#xD;
        measurements in breast cancer patients, to investigate whether and to what extent there is a&#xD;
        difference, whether and to what extent there is a difference between demographic information,&#xD;
        disease stages, comorbidity level, clinical features, peripheral muscle strength, fatigue and&#xD;
        quality of life and upper extremity functionality according to quadrants.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Not yet recruiting</overall_status>
    <start_date type="Anticipated">September 30, 2023</start_date>
    <completion_date type="Anticipated">July 1, 2024</completion_date>
    <primary_completion_date type="Anticipated">May 1, 2024</primary_completion_date>
    <study_type>Observational</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <observational_model>Other</observational_model>
      <time_perspective>Prospective</time_perspective>
    </study_design_info>
    <primary_outcome>
      <measure>Functional Exercise Capacity</measure>
      <time_frame>One Year</time_frame>
      <description>Six-minute walk test (6MWT)</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Physical Activity Level</measure>
      <time_frame>One Year</time_frame>
      <description>SenseWear Armband (SWA)</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Comorbidity Assessment</measure>
      <time_frame>One Year</time_frame>
      <description>The Charlson Comorbidity Index According to this index developed by the Institute of Medicine, comorbid diseases are assessed according to their severity. is scored. Comorbidities are scored from mild disease state to severe disease state. are given a score of 1, 2, 3, 4, respectively, and the score obtained by summing the scores of comorbid diseases The severity of comorbidity is also calculated according to the weighted score. One point for every ten years over the age of forty (50-59: 1 point, 60-69: 2 points, etc.)</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Peripheral muscle strength assessment</measure>
      <time_frame>One Year</time_frame>
      <description>Peripheral muscle strength (knee extensors, shoulder abductors and hand grip strength) will be measured using a handheld digital dynamometer</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Evaluation of Upper Extremity Functionality</measure>
      <time_frame>One Year</time_frame>
      <description>Questionnaire Disability of Arm, Shoulder and Hand (Q-DASH) Each item is scored on a 5-point Likert scale (1-5).The maximum score is 100 points. Score increase shows an increase in disability</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Fatigue Assessment</measure>
      <time_frame>One Year</time_frame>
      <description>Piper Fatigue Scale (PFS) Responses for each item It is evaluated between 0-10 points. The total fatigue score is based on 22 items scores are summed and divided by the number of items. Scale obtained from high scores indicate a high level of perceived fatigue shows.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Evaluation of Quality of Life</measure>
      <time_frame>One Year</time_frame>
      <description>European Organization for Research and Treatment of Cancer Quality of Life (EORTC QLQ-C30) All scores were linearly transformed to a 0 to 100 scale. A high or healthy level of functioning is represented by a high functional score</description>
    </secondary_outcome>
    <enrollment type="Anticipated">60</enrollment>
    <condition>Breast Cancer</condition>
    <condition>Exercise Capacity</condition>
    <condition>Physical Activity</condition>
    <eligibility>
      <study_pop>
        <textblock>
          Patients between the ages of 18-65 who were diagnosed with breast cancer in Hacettepe&#xD;
          University Hospital, Department of Internal Medicine, Department of Medical Oncology and&#xD;
          volunteered to participate in the study will be included in the study.&#xD;
        </textblock>
      </study_pop>
      <sampling_method>Probability Sample</sampling_method>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            1. Being between 18-65 years of age,&#xD;
  &#xD;
            2. Volunteering to participate in the research,&#xD;
  &#xD;
            3. At least 15 months after breast cancer surgery,&#xD;
  &#xD;
            4. Six months after active breast cancer treatment (i.e. surgery/chemotherapy),&#xD;
  &#xD;
            5. No problems in reading and/or understanding the scales and being able to cooperate&#xD;
               with the tests,&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            1. Presence of active infection,&#xD;
  &#xD;
            2. Musculoskeletal and neurological diseases that may affect exercise performance,&#xD;
               symptomatic heart disease,&#xD;
  &#xD;
            3. Have a neurological disease or other clinical diagnosis that may affect cognitive&#xD;
               status.&#xD;
  &#xD;
            4. Musculoskeletal and neurologic disease, symptomatic heart disease, previous lung&#xD;
               surgery and malignant disease that may affect exercise performance.&#xD;
  &#xD;
            5. Presence of unstable hypertension or diabetes mellitus&#xD;
        </textblock>
      </criteria>
      <gender>Female</gender>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>65 Years</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Ebru Calik-Kutukcu, PhD</last_name>
      <role>Principal Investigator</role>
      <affiliation>Hacettepe University</affiliation>
    </overall_official>
    <overall_official>
      <last_name>Melda Saglam, PhD</last_name>
      <role>Study Chair</role>
      <affiliation>Hacettepe University</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Ebru Calik Kutukcu, PhD</last_name>
      <phone>+903123051576</phone>
      <phone_ext>195</phone_ext>
      <email>ebru.calik@hacettepe.edu.tr</email>
    </overall_contact>
    <overall_contact_backup>
      <last_name>Naciye Vardar-Yagli, PhD</last_name>
      <phone>+03123051576</phone>
      <phone_ext>129</phone_ext>
      <email>naciyevardar@yahoo.com</email>
    </overall_contact_backup>
    <location>
      <facility>
        <name>Ebru Çalık Kutukcu</name>
        <address>
          <city>Ankara</city>
          <state>Hacettepe Unıversity</state>
          <zip>06100</zip>
          <country>Turkey</country>
        </address>
      </facility>
    </location>
    <location_countries>
      <country>Turkey</country>
    </location_countries>
    <verification_date>September 2023</verification_date>
    <study_first_submitted>August 24, 2023</study_first_submitted>
    <study_first_submitted_qc>August 24, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 30, 2023</study_first_posted>
    <last_update_submitted>September 1, 2023</last_update_submitted>
    <last_update_submitted_qc>September 1, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">September 6, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Principal Investigator</responsible_party_type>
      <investigator_affiliation>Hacettepe University</investigator_affiliation>
      <investigator_full_name>Ebru Calik Kutukcu</investigator_full_name>
      <investigator_title>Associate Professor</investigator_title>
    </responsible_party>
    <keyword>breast cancer</keyword>
    <keyword>Quality of life.</keyword>
    <keyword>exercise</keyword>
    <keyword>physical activity</keyword>
    <keyword>Physical capacity</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Breast Neoplasms</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT06018051
  org study id: GO 23/582
  nct id: NCT06018051
  lead sponsor: 
  has dmc: No
  is fda regulated drug: No
  is fda regulated device: No
  Breast cancer occurs as a result of uncontrolled proliferation of cells in the breast tissue.
        Breast cancer is the most common type of cancer among women worldwide and is an important
        problem that threatens women's lives. The incidence rate has reached approximately 16 Breast
        cancer treatment consists of local and systemic therapies. While local treatments include
        surgery and radiotherapy, systemic treatments, which are administered in two different ways,
        namely adjuvant and neoadjuvant systemic treatments, consist of chemotherapy, hormone therapy
        and targeted biological therapies. Although the treatment options for breast cancer are
        increasing day by day, there are many complications during and after treatment. These
        complications negatively affect functionality and quality of life The 6-minute walk test
        (6MWD) is a widely used test for indirect measurement of cardiorespiratory fitness in various
        cancer populations. Studies have proven that the 6MWT is safe and feasible in breast cancer
        patients. The concept of 'can do, do do' has recently emerged to describe impaired physical
        functions in chronic obstructive pulmonary disease (COPD) and asthma. This concept
        categorizes participants into four quadrants based on physical activity level and functional
        capacity measurements and cut-off point. This concept has proven useful for measuring
        physical function in both asthma and COPD. This concept may be useful in understanding
        physical functioning in breast cancer patients. Therefore, The aim of this study is to apply
        the concept of 'can do, do do' in breast cancer patients, to determine the quadrants
        according to physical activity level and functional capacity measurements in breast cancer
        patients, to investigate whether and to what extent there is a difference, whether and to
        what extent there is a difference between demographic information, disease stages,
        comorbidity level, clinical features, peripheral muscle strength, fatigue and quality of life
        and upper extremity functionality according to quadrants.
  Breast cancer occurs as a result of uncontrolled proliferation of cells in the breast tissue.
        Breast cancer is the most common type of cancer among women worldwide and is an important
        problem that threatens women's lives. The incidence rate has reached approximately 16 Breast
        cancer treatment consists of local and systemic therapies. While local treatments include
        surgery and radiotherapy, systemic treatments, which are administered in two different ways,
        namely adjuvant and neoadjuvant systemic treatments, consist of chemotherapy, hormone therapy
        and targeted biological therapies. Although the treatment options for breast cancer are
        increasing day by day, there are many complications during and after treatment. These
        complications negatively affect functionality and quality of life.
  
        Thanks to the increasing treatment possibilities with the developing technology in recent
        years, the majority of patients show good functional recovery after breast cancer. However,
        it has been reported that treatments negatively affect the functional capacity of the upper
        extremities, daily life, work and social activities and decrease the quality of life. Many
        side effects are observed in patients after breast cancer treatment. Therefore, there are
        various rehabilitation needs. Side effects vary from person to person. Therefore, the
        rehabilitation program to be applied should be personalized. Commonly reported side effects
        of the disease or treatments include pain, lymphedema, fatigue and depression. In addition,
        psychosocial consequences and psychological distress, such as reduced health-related quality
        of life and reduced social contacts, as well as difficulties in maintaining functional
        activities and life roles, have been reported. As a result, breast cancer patients may have
        physical, psychological, social and existential rehabilitation needs.
  
        Exercise is an effective non-pharmacologic treatment method in cancer patients. Exercise also
        has therapeutic properties in cancer-related fatigue. Increased physical activity has been
        reported to improve psychological recovery and physical well-being in cancer patients.
        Aerobic exercise has been proven to reduce cancer-related fatigue as a result of studies. It
        has also been reported that supervised exercise during chemotherapy or radiotherapy
        treatments both increases the effectiveness of the treatment and reduces the side effects
        that may occur. In addition, resistance exercises significantly reduce cancer-related
        fatigue. There is evidence that there is a strong relationship between the risk of breast
        cancer and physical activity level. Exercise training is an important physiotherapy and
        rehabilitation approach in breast cancer survivors. According to randomized controlled trials
        on the outcomes of exercise modalities in women with breast cancer, women who exercise have
        improved survival rates. Physical and psychological conditions such as fatigue, pain,
        anxiety, depression and decreased functional capacity reduce patients' quality of life.
        Exercise interventions during or after treatment have been reported to improve
        musculoskeletal performance, cardiorespiratory fitness, body awareness, and psychological
        status in breast cancer. Previous studies have also reported that exercise training programs
        to be applied during or after cancer treatment in cancer patients improve quality of life. It
        has been reported that mind-body togetherness exercises such as aerobic, resistance,
        stretching, yoga, and Tai Chi in breast cancer patients improve quality of life and general
        and mental health, and have a positive effect on of the maximal oxygen uptake (VO2 max) , and
        provide significant improvements in self-esteem and attitude towards life. In addition,
        exercise training alleviates symptoms of depression and anxiety in breast cancer survivors.
        In addition to reducing body mass index (BMI) and causing significant increases in lean mass,
        exercise also increases muscle strength in the intervention groups. Furthermore, the serum
        concentration of some physiological markers, such as insulin, insulin-like growth factor
        (IGF-II) and insulin-like growth factor binding protein (IGFBP-1), is significantly reduced
        after the exercise intervention. Physical activity has been shown to improve the symptom of
        fatigue.
  
        The type, intensity, intensity and duration of the exercise to be applied differ from person
        to person. Exercise intervention is safe both during and after systemic treatments.
        Therefore, exercise intervention should be prescribed to breast cancer patients and they
        should be encouraged to maintain their established exercise habits or adopt a correct type of
        exercise.
  
        The most widely accepted exercise regimen for breast cancer patients is about 150 minutes of
        moderate to vigorous intensity aerobic exercise per week. However, only 30% to 47% of breast
        cancer survivors are reported to adhere to the recommended exercise programs. Furthermore,
        aerobic exercise, strengthening exercises or body-mind exercises have a significant impact on
        side effects after cancer treatments. Aerobic and resistance exercises reduce physical and
        psychosocial problems associated with cancer and cancer treatment. Breast cancer survivors
        are also recommended mindfulness, yoga or body-mind exercises to feel better and more
        relaxed. Breathing exercises during physical activity are important for relaxation.
  
        The 6-minute walk test (6MWD) is a widely used test for indirect measurement of
        cardiorespiratory fitness in various cancer populations. Studies have proven that the 6MWT is
        safe and feasible in breast cancer patients. The concept of 'can do, do do' has recently
        emerged to describe impaired physical functions in chronic obstructive pulmonary disease
        (COPD) and asthma. This concept categorizes investigators into four quadrants based on
        physical activity level and functional capacity measurements and cut-off point. This concept
        has proven useful for measuring physical function in both asthma and COPD. This concept may
        be useful in understanding physical functioning in breast cancer patients. Therefore, The aim
        of this study is to apply the concept of 'can do, do do' in breast cancer patients, to
        determine the quadrants according to physical activity level and functional capacity
        measurements in breast cancer patients, to investigate whether and to what extent there is a
        difference, whether and to what extent there is a difference between demographic information,
        disease stages, comorbidity level, clinical features, peripheral muscle strength, fatigue and
        quality of life and upper extremity functionality according to quadrants.
  observational model: Other
  time perspective: Prospective
  measure: Functional Exercise Capacity
  time frame: One Year
  description: Six-minute walk test (6MWT)
  measure: Physical Activity Level
  time frame: One Year
  description: SenseWear Armband (SWA)
  measure: Comorbidity Assessment
  time frame: One Year
  description: The Charlson Comorbidity Index According to this index developed by the Institute of Medicine, comorbid diseases are assessed according to their severity. is scored. Comorbidities are scored from mild disease state to severe disease state. are given a score of 1, 2, 3, 4, respectively, and the score obtained by summing the scores of comorbid diseases The severity of comorbidity is also calculated according to the weighted score. One point for every ten years over the age of forty (50-59: 1 point, 60-69: 2 points, etc.)
  measure: Peripheral muscle strength assessment
  time frame: One Year
  description: Peripheral muscle strength (knee extensors, shoulder abductors and hand grip strength) will be measured using a handheld digital dynamometer
  measure: Evaluation of Upper Extremity Functionality
  time frame: One Year
  description: Questionnaire Disability of Arm, Shoulder and Hand (Q-DASH) Each item is scored on a 5-point Likert scale (1-5).The maximum score is 100 points. Score increase shows an increase in disability
  measure: Fatigue Assessment
  time frame: One Year
  description: Piper Fatigue Scale (PFS) Responses for each item It is evaluated between 0-10 points. The total fatigue score is based on 22 items scores are summed and divided by the number of items. Scale obtained from high scores indicate a high level of perceived fatigue shows.
  measure: Evaluation of Quality of Life
  time frame: One Year
  description: European Organization for Research and Treatment of Cancer Quality of Life (EORTC QLQ-C30) All scores were linearly transformed to a 0 to 100 scale. A high or healthy level of functioning is represented by a high functional score
  study pop: 
  sampling method: Probability Sample
  criteria: 
  gender: Female
  minimum age: 18 Years
  maximum age: 65 Years
  healthy volunteers: No
  last name: Ebru Calik-Kutukcu, PhD
  role: Principal Investigator
  affiliation: Hacettepe University
  last name: Melda Saglam, PhD
  role: Study Chair
  affiliation: Hacettepe University
  last name: Ebru Calik Kutukcu, PhD
  phone: +903123051576
  phone ext: 195
  email: ebru.calik@hacettepe.edu.tr
  last name: Naciye Vardar-Yagli, PhD
  phone: +03123051576
  phone ext: 129
  email: naciyevardar@yahoo.com
  facility: 
  country: Turkey
  responsible party type: Principal Investigator
  investigator affiliation: Hacettepe University
  investigator full name: Ebru Calik Kutukcu
  investigator title: Associate Professor
  mesh term: Breast Neoplasms
  sharing ipd: No