xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT06041906</url>
    </required_header>
    <id_info>
      <org_study_id>2018-00413</org_study_id>
      <nct_id>NCT06041906</nct_id>
    </id_info>
    <brief_title>International Registry of Congenital Portosystemic Shunt (IRCPSS)</brief_title>
    <acronym>IRCPSS</acronym>
    <official_title>International Registry of Congenital Portosystemic Shunts (IRCPSS) - A Multi-centre, Retrospective and Prospective Registry of Neonates, Children and Adults With Congenital Portosystemic Shunts</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Prof. Valérie Mc Lin</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
      <collaborator>
        <agency>European Society of Pediatric Gastroenterology, Hepatology and Nutrition</agency>
        <agency_class>Other</agency_class>
      </collaborator>
      <collaborator>
        <agency>European Association for the Study of the Liver (EASL)</agency>
        <agency_class>Other</agency_class>
      </collaborator>
      <collaborator>
        <agency>Fondation Andrea Ferrari</agency>
        <agency_class>Other</agency_class>
      </collaborator>
    </sponsors>
    <source>University Hospital, Geneva</source>
    <oversight_info>
      <has_dmc>No</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        Congenital Portosystemic Shunt (CPSS) is a rare condition important by the multiplicity and&#xD;
        severity of associated complications.&#xD;
  &#xD;
        CPSS is venous anomaly in which blood coming from the intestines only partially passes&#xD;
        through the liver.&#xD;
  &#xD;
        This leads to the accumulation of potentially toxic factors that cause systemic effects.&#xD;
  &#xD;
        Complications vary among the individuals, and currently, it is challenging to predict which&#xD;
        individuals will develop severe complications.&#xD;
  &#xD;
        The IRCPSS registry is established with the aim of centralizing detailed clinical follow-up&#xD;
        and biological information from participants around the world who suffer from Congenital&#xD;
        Portosystemic Shunt (CPSS). A multidisciplinary consortium of experts is collaborating to&#xD;
        enhance our understanding of the prevalence, natural history, individual risks, and&#xD;
        physiopathology of the disease through the IRCPSS registry.&#xD;
      </textblock>
    </brief_summary>
    <overall_status>Enrolling by invitation</overall_status>
    <start_date type="Actual">April 26, 2018</start_date>
    <completion_date type="Anticipated">December 31, 2028</completion_date>
    <primary_completion_date type="Anticipated">October 26, 2026</primary_completion_date>
    <study_type>Observational [Patient Registry]</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <observational_model>Cohort</observational_model>
      <time_perspective>Other</time_perspective>
    </study_design_info>
    <target_duration>20 Years</target_duration>
    <primary_outcome>
      <measure>Numbers of patients with spontaneous shunt closure</measure>
      <time_frame>3; 6; 12; 24 months</time_frame>
    </primary_outcome>
    <primary_outcome>
      <measure>Number of patients developing one or more complications</measure>
      <time_frame>5; 10; 20 years</time_frame>
    </primary_outcome>
    <primary_outcome>
      <measure>Number of patients undergoing preemptive closure</measure>
      <time_frame>6; 12; 24 months</time_frame>
    </primary_outcome>
    <number_of_groups>1</number_of_groups>
    <enrollment type="Anticipated">500</enrollment>
    <condition>Congenital Porto-Systemic Shunt (CPSS)</condition>
    <arm_group>
      <arm_group_label>Neonate, Children, Adult with CPSS</arm_group_label>
    </arm_group>
    <intervention>
      <intervention_type>Procedure</intervention_type>
      <intervention_name>Shunt Closure</intervention_name>
      <description>Consist in spontaneous, surgical or interventional closure of the shunt. Depending on context, surgical intervention may also be transplantation.</description>
      <arm_group_label>Neonate, Children, Adult with CPSS</arm_group_label>
    </intervention>
    <eligibility>
      <study_pop>
        <textblock>
          neonates; children; adults&#xD;
        </textblock>
      </study_pop>
      <sampling_method>Non-Probability Sample</sampling_method>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
          Individual with CPSS&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
          Secondary shunt without evidence of congenital shunt&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>1 Day</minimum_age>
      <maximum_age>N/A</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Valérie A Mc Lin, Prof. Dr. med.</last_name>
      <role>Study Director</role>
      <affiliation>University Hospital, Geneva</affiliation>
    </overall_official>
    <location>
      <facility>
        <name>Yale University School of Medicine</name>
        <address>
          <city>New Haven</city>
          <state>Connecticut</state>
          <zip>06520</zip>
          <country>United States</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Royal Children's Hospital Melbourne</name>
        <address>
          <city>Parkville</city>
          <state>Victoria</state>
          <zip>3052</zip>
          <country>Australia</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Universitary Clinics Saint-Luc, UCL</name>
        <address>
          <city>Brussels</city>
          <zip>1200</zip>
          <country>Belgium</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>The Hospital for Sick Children</name>
        <address>
          <city>Toronto</city>
          <state>Ontario</state>
          <zip>M5G 1X8</zip>
          <country>Canada</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Beaujon University Hospital</name>
        <address>
          <city>Clichy</city>
          <zip>92100</zip>
          <country>France</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Hôpital Bicêtre-Hôpitaux Universitaires Paris-Sud- Assistance Publique Hôpitaux de Paris.</name>
        <address>
          <city>Le Kremlin-Bicêtre</city>
          <zip>94275</zip>
          <country>France</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Hôpital Necker</name>
        <address>
          <city>Paris</city>
          <zip>75743</zip>
          <country>France</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Haunersche Kinderklinik - LMU Munich</name>
        <address>
          <city>Munich</city>
          <zip>80337</zip>
          <country>Germany</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>University of Tuebingen</name>
        <address>
          <city>Tuebingen</city>
          <zip>72076</zip>
          <country>Germany</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>&quot;Agia Sofia&quot; Children's Hospital</name>
        <address>
          <city>Athens</city>
          <zip>11527</zip>
          <country>Greece</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>&quot; ATTIKON &quot; University Hospital</name>
        <address>
          <city>Chaidari</city>
          <zip>12462</zip>
          <country>Greece</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>First Department of Pediatrics, Semmelweis University</name>
        <address>
          <city>Budapest</city>
          <zip>1083</zip>
          <country>Hungary</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Department of Pediatric Hepatology Institute of Liver and Biliary Sciences</name>
        <address>
          <city>New Delhi</city>
          <zip>110070</zip>
          <country>India</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Schneider Children's Medical Center of Israel</name>
        <address>
          <city>Petach Tikvah</city>
          <zip>49202</zip>
          <country>Israel</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Children's Hospital Santobono</name>
        <address>
          <city>Naples</city>
          <zip>80129</zip>
          <country>Italy</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Istituto di Ricovero e Cura a Carattere Scientifico (ISMETT)</name>
        <address>
          <city>Palermo</city>
          <zip>90127</zip>
          <country>Italy</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>National Center for Child Health and Development</name>
        <address>
          <city>Tokyo</city>
          <zip>157-8535</zip>
          <country>Japan</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Academic Medical Centre</name>
        <address>
          <city>Amsterdam</city>
          <zip>1105</zip>
          <country>Netherlands</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>University Medical Center Groningen</name>
        <address>
          <city>Groningen</city>
          <zip>9700 RB</zip>
          <country>Netherlands</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Hospital Clínic de Barcelona</name>
        <address>
          <city>Barcelona</city>
          <zip>08036</zip>
          <country>Spain</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Hôpitaux Universitaires de Geneve (HUG)</name>
        <address>
          <city>Geneva</city>
          <state>GE</state>
          <zip>1205</zip>
          <country>Switzerland</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Gazi University, Faculty of Medicine</name>
        <address>
          <city>Yenimahalle</city>
          <state>Ankara</state>
          <zip>06560</zip>
          <country>Turkey</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Koc University School of Medicine</name>
        <address>
          <city>Istanbul</city>
          <zip>34010</zip>
          <country>Turkey</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Birmingham Children's Hospital</name>
        <address>
          <city>Birmingham</city>
          <zip>B4 6NH</zip>
          <country>United Kingdom</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Royal Hospital for Children and Young People</name>
        <address>
          <city>Edinburgh</city>
          <zip>EH16 4TJ</zip>
          <country>United Kingdom</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Leeds General Infirmary</name>
        <address>
          <city>Leeds</city>
          <zip>LS1 3EX</zip>
          <country>United Kingdom</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Royal Free London NHS Foundation Trust</name>
        <address>
          <city>London</city>
          <zip>NW3 2QG</zip>
          <country>United Kingdom</country>
        </address>
      </facility>
    </location>
    <location>
      <facility>
        <name>Kings College Hospital</name>
        <address>
          <city>London</city>
          <zip>SE5 9RS</zip>
          <country>United Kingdom</country>
        </address>
      </facility>
    </location>
    <location_countries>
      <country>Australia</country>
      <country>Belgium</country>
      <country>Canada</country>
      <country>France</country>
      <country>Germany</country>
      <country>Greece</country>
      <country>Hungary</country>
      <country>India</country>
      <country>Israel</country>
      <country>Italy</country>
      <country>Japan</country>
      <country>Netherlands</country>
      <country>Spain</country>
      <country>Switzerland</country>
      <country>Turkey</country>
      <country>United Kingdom</country>
      <country>United States</country>
    </location_countries>
    <link>
      <url>https://ircpss.com/</url>
      <description>International Registry of Congenital Portosystemic Shunts website, for patients and professionals</description>
    </link>
    <reference>
      <citation>Hanquinet S, Morice C, Courvoisier DS, Cousin V, Anooshiravani M, Merlini L, McLin VA. Globus pallidus MR signal abnormalities in children with chronic liver disease and/or porto-systemic shunting. Eur Radiol. 2017 Oct;27(10):4064-4071. doi: 10.1007/s00330-017-4808-x. Epub 2017 Apr 6.</citation>
      <PMID>28386718</PMID>
    </reference>
    <reference>
      <citation>Cudalbu C, McLin VA, Lei H, Duarte JM, Rougemont AL, Oldani G, Terraz S, Toso C, Gruetter R. The C57BL/6J mouse exhibits sporadic congenital portosystemic shunts. PLoS One. 2013 Jul 23;8(7):e69782. doi: 10.1371/journal.pone.0069782. Print 2013.</citation>
      <PMID>23936100</PMID>
    </reference>
    <reference>
      <citation>Joye R, Lador F, Aggoun Y, Farhat N, Wacker J, Wildhaber BE, Vallee JP, Hachulla AL, McLin VA, Beghetti M. Outcome of paediatric portopulmonary hypertension in the modern management era: A case report of 6 patients. J Hepatol. 2021 Mar;74(3):742-747. doi: 10.1016/j.jhep.2020.11.039. Epub 2020 Dec 1.</citation>
      <PMID>33276028</PMID>
    </reference>
    <reference>
      <citation>McLin V, Beghetti M, D'Antiga L, Franchi-Abella S; International Registry of Congenital Porto-Systemic Shunts (IRCPSS). Current Quandaries in the Management of Congenital Portosystemic Shunts. Liver Transpl. 2021 Aug;27(8):1212-1213. doi: 10.1002/lt.26055. Epub 2021 Jul 20. No abstract available.</citation>
      <PMID>33749116</PMID>
    </reference>
    <reference>
      <citation>Korff S, Mostaguir K, Beghetti M, D'Antiga L, Debray D, Franchi-Abella S, Gonzales E, Guerin F, Hachulla AL, Lambert V, Makrythanasis P, Roduit N, Savale L, Senat MV, Spaltenstein J, van Steenbeek F, Wildhaber BE, Zwahlen M, McLin VA. International registry of congenital porto-systemic shunts: a multi-centre, retrospective and prospective registry of neonates, children and adults with congenital porto-systemic shunts. Orphanet J Rare Dis. 2022 Jul 19;17(1):284. doi: 10.1186/s13023-022-02412-8.</citation>
      <PMID>35854389</PMID>
    </reference>
    <reference>
      <citation>Lambert V, Ladarre D, Fortas F, Durand P, Herve P, Gonzales E, Guerin F, Savale L, McLin VA, Ackermann O, Franchi-Abella S; International Registry of Congenital Portosystemic Shunts (IRCPSS). Cardiovascular disorders in patients with congenital portosystemic shunts: 23 years of experience in a tertiary referral centre. Arch Cardiovasc Dis. 2021 Mar;114(3):221-231. doi: 10.1016/j.acvd.2020.10.003. Epub 2020 Dec 3.</citation>
      <PMID>33281106</PMID>
    </reference>
    <reference>
      <citation>McLin VA, D'Antiga L. The current pediatric perspective on type B and C hepatic encephalopathy. Anal Biochem. 2022 Apr 15;643:114576. doi: 10.1016/j.ab.2022.114576. Epub 2022 Jan 29.</citation>
      <PMID>35104444</PMID>
    </reference>
    <reference>
      <citation>McLin VA, Franchi Abella S, Debray D, Guerin F, Beghetti M, Savale L, Wildhaber BE, Gonzales E; Members of the International Registry of Congenital Porto-Systemic Shunts. Congenital Portosystemic Shunts: Current Diagnosis and Management. J Pediatr Gastroenterol Nutr. 2019 May;68(5):615-622. doi: 10.1097/MPG.0000000000002263.</citation>
      <PMID>30628988</PMID>
    </reference>
    <reference>
      <citation>Bahadori A, Kuhlmann B, Debray D, Franchi-Abella S, Wacker J, Beghetti M, Wildhaber BE, McLin VA, On Behalf Of The Ircpss. Presentation of Congenital Portosystemic Shunts in Children. Children (Basel). 2022 Feb 11;9(2):243. doi: 10.3390/children9020243.</citation>
      <PMID>35204963</PMID>
    </reference>
    <reference>
      <citation>Guerin F, Franchi Abella S, McLin V, Ackermann O, Girard M, Cervoni JP, Savale L, Hernandez-Gea V, Valla D, Hillaire S, Dutheil D, Bureau C, Gonzales E, Plessier A. Congenital portosystemic shunts: Vascular liver diseases: Position papers from the francophone network for vascular liver diseases, the French Association for the Study of the Liver (AFEF), and ERN-rare liver. Clin Res Hepatol Gastroenterol. 2020 Sep;44(4):452-459. doi: 10.1016/j.clinre.2020.03.004. Epub 2020 Apr 9. No abstract available.</citation>
      <PMID>32279979</PMID>
    </reference>
    <reference>
      <citation>Rock NM, Beghetti M, Tissot C, Willi JP, Bouhabib M, McLin VA, Maggio ABR. Reliable Detection of Intrapulmonary Shunts Using Contrast-Enhanced Echocardiography in Children With Portal Hypertension or Portosystemic Shunt. J Pediatr Gastroenterol Nutr. 2021 Jul 1;73(1):73-79. doi: 10.1097/MPG.0000000000003079.</citation>
      <PMID>33605662</PMID>
    </reference>
    <verification_date>September 2023</verification_date>
    <study_first_submitted>September 11, 2023</study_first_submitted>
    <study_first_submitted_qc>September 11, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">September 18, 2023</study_first_posted>
    <last_update_submitted>September 11, 2023</last_update_submitted>
    <last_update_submitted_qc>September 11, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">September 18, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Sponsor-Investigator</responsible_party_type>
      <investigator_affiliation>University Hospital, Geneva</investigator_affiliation>
      <investigator_full_name>Prof. Valérie Mc Lin</investigator_full_name>
      <investigator_title>Prof. Dr. med.</investigator_title>
    </responsible_party>
    <keyword>shunt</keyword>
    <keyword>portosystemic</keyword>
    <keyword>portasystemic</keyword>
    <keyword>porto-systemic</keyword>
    <keyword>porta-systemic</keyword>
    <keyword>registry</keyword>
    <keyword>liver</keyword>
    <keyword>rare disease</keyword>
    <keyword>Abernethy malformation</keyword>
    <keyword>vascular malformation</keyword>
    <keyword>Hypertension, Pulmonary</keyword>
    <keyword>Hepatopulmonary Syndrome</keyword>
    <keyword>Liver Neoplasms</keyword>
    <keyword>hyperinsulinemic</keyword>
    <keyword>hypoglycemia</keyword>
    <keyword>hyperinsulinism</keyword>
    <keyword>Insulin resistance</keyword>
    <keyword>hyperandrogenism</keyword>
    <keyword>Hepatic Encephalopathy</keyword>
    <keyword>Hyperammonemia</keyword>
    <patient_data>
      <sharing_ipd>Undecided</sharing_ipd>
      <ipd_description>undecided</ipd_description>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT06041906
  org study id: 2018-00413
  nct id: NCT06041906
  lead sponsor: 
  collaborator: 
  collaborator: 
  collaborator: 
  has dmc: No
  is fda regulated drug: No
  is fda regulated device: No
  Congenital Portosystemic Shunt (CPSS) is a rare condition important by the multiplicity and
        severity of associated complications.
  
        CPSS is venous anomaly in which blood coming from the intestines only partially passes
        through the liver.
  
        This leads to the accumulation of potentially toxic factors that cause systemic effects.
  
        Complications vary among the individuals, and currently, it is challenging to predict which
        individuals will develop severe complications.
  
        The IRCPSS registry is established with the aim of centralizing detailed clinical follow-up
        and biological information from participants around the world who suffer from Congenital
        Portosystemic Shunt (CPSS). A multidisciplinary consortium of experts is collaborating to
        enhance our understanding of the prevalence, natural history, individual risks, and
        physiopathology of the disease through the IRCPSS registry.
  observational model: Cohort
  time perspective: Other
  measure: Numbers of patients with spontaneous shunt closure
  time frame: 3; 6; 12; 24 months
  measure: Number of patients developing one or more complications
  time frame: 5; 10; 20 years
  measure: Number of patients undergoing preemptive closure
  time frame: 6; 12; 24 months
  arm group label: Neonate, Children, Adult with CPSS
  intervention type: Procedure
  intervention name: Shunt Closure
  description: Consist in spontaneous, surgical or interventional closure of the shunt. Depending on context, surgical intervention may also be transplantation.
  arm group label: Neonate, Children, Adult with CPSS
  study pop: 
  sampling method: Non-Probability Sample
  criteria: 
  gender: All
  minimum age: 1 Day
  maximum age: N/A
  healthy volunteers: No
  last name: Valérie A Mc Lin, Prof. Dr. med.
  role: Study Director
  affiliation: University Hospital, Geneva
  facility: 
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  facility: 
  country: Australia
  country: Belgium
  country: Canada
  country: France
  country: Germany
  country: Greece
  country: Hungary
  country: India
  country: Israel
  country: Italy
  country: Japan
  country: Netherlands
  country: Spain
  country: Switzerland
  country: Turkey
  country: United Kingdom
  country: United States
  url: https://ircpss.com/
  description: International Registry of Congenital Portosystemic Shunts website, for patients and professionals
  citation: Hanquinet S, Morice C, Courvoisier DS, Cousin V, Anooshiravani M, Merlini L, McLin VA. Globus pallidus MR signal abnormalities in children with chronic liver disease and/or porto-systemic shunting. Eur Radiol. 2017 Oct;27(10):4064-4071. doi: 10.1007/s00330-017-4808-x. Epub 2017 Apr 6.
  PMID: 28386718
  citation: Cudalbu C, McLin VA, Lei H, Duarte JM, Rougemont AL, Oldani G, Terraz S, Toso C, Gruetter R. The C57BL/6J mouse exhibits sporadic congenital portosystemic shunts. PLoS One. 2013 Jul 23;8(7):e69782. doi: 10.1371/journal.pone.0069782. Print 2013.
  PMID: 23936100
  citation: Joye R, Lador F, Aggoun Y, Farhat N, Wacker J, Wildhaber BE, Vallee JP, Hachulla AL, McLin VA, Beghetti M. Outcome of paediatric portopulmonary hypertension in the modern management era: A case report of 6 patients. J Hepatol. 2021 Mar;74(3):742-747. doi: 10.1016/j.jhep.2020.11.039. Epub 2020 Dec 1.
  PMID: 33276028
  citation: McLin V, Beghetti M, D'Antiga L, Franchi-Abella S; International Registry of Congenital Porto-Systemic Shunts (IRCPSS). Current Quandaries in the Management of Congenital Portosystemic Shunts. Liver Transpl. 2021 Aug;27(8):1212-1213. doi: 10.1002/lt.26055. Epub 2021 Jul 20. No abstract available.
  PMID: 33749116
  citation: Korff S, Mostaguir K, Beghetti M, D'Antiga L, Debray D, Franchi-Abella S, Gonzales E, Guerin F, Hachulla AL, Lambert V, Makrythanasis P, Roduit N, Savale L, Senat MV, Spaltenstein J, van Steenbeek F, Wildhaber BE, Zwahlen M, McLin VA. International registry of congenital porto-systemic shunts: a multi-centre, retrospective and prospective registry of neonates, children and adults with congenital porto-systemic shunts. Orphanet J Rare Dis. 2022 Jul 19;17(1):284. doi: 10.1186/s13023-022-02412-8.
  PMID: 35854389
  citation: Lambert V, Ladarre D, Fortas F, Durand P, Herve P, Gonzales E, Guerin F, Savale L, McLin VA, Ackermann O, Franchi-Abella S; International Registry of Congenital Portosystemic Shunts (IRCPSS). Cardiovascular disorders in patients with congenital portosystemic shunts: 23 years of experience in a tertiary referral centre. Arch Cardiovasc Dis. 2021 Mar;114(3):221-231. doi: 10.1016/j.acvd.2020.10.003. Epub 2020 Dec 3.
  PMID: 33281106
  citation: McLin VA, D'Antiga L. The current pediatric perspective on type B and C hepatic encephalopathy. Anal Biochem. 2022 Apr 15;643:114576. doi: 10.1016/j.ab.2022.114576. Epub 2022 Jan 29.
  PMID: 35104444
  citation: McLin VA, Franchi Abella S, Debray D, Guerin F, Beghetti M, Savale L, Wildhaber BE, Gonzales E; Members of the International Registry of Congenital Porto-Systemic Shunts. Congenital Portosystemic Shunts: Current Diagnosis and Management. J Pediatr Gastroenterol Nutr. 2019 May;68(5):615-622. doi: 10.1097/MPG.0000000000002263.
  PMID: 30628988
  citation: Bahadori A, Kuhlmann B, Debray D, Franchi-Abella S, Wacker J, Beghetti M, Wildhaber BE, McLin VA, On Behalf Of The Ircpss. Presentation of Congenital Portosystemic Shunts in Children. Children (Basel). 2022 Feb 11;9(2):243. doi: 10.3390/children9020243.
  PMID: 35204963
  citation: Guerin F, Franchi Abella S, McLin V, Ackermann O, Girard M, Cervoni JP, Savale L, Hernandez-Gea V, Valla D, Hillaire S, Dutheil D, Bureau C, Gonzales E, Plessier A. Congenital portosystemic shunts: Vascular liver diseases: Position papers from the francophone network for vascular liver diseases, the French Association for the Study of the Liver (AFEF), and ERN-rare liver. Clin Res Hepatol Gastroenterol. 2020 Sep;44(4):452-459. doi: 10.1016/j.clinre.2020.03.004. Epub 2020 Apr 9. No abstract available.
  PMID: 32279979
  citation: Rock NM, Beghetti M, Tissot C, Willi JP, Bouhabib M, McLin VA, Maggio ABR. Reliable Detection of Intrapulmonary Shunts Using Contrast-Enhanced Echocardiography in Children With Portal Hypertension or Portosystemic Shunt. J Pediatr Gastroenterol Nutr. 2021 Jul 1;73(1):73-79. doi: 10.1097/MPG.0000000000003079.
  PMID: 33605662
  responsible party type: Sponsor-Investigator
  investigator affiliation: University Hospital, Geneva
  investigator full name: Prof. Valérie Mc Lin
  investigator title: Prof. Dr. med.
  sharing ipd: Undecided
  ipd description: undecided