xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT05976087</url>
    </required_header>
    <id_info>
      <org_study_id>1-010428</org_study_id>
      <nct_id>NCT05976087</nct_id>
    </id_info>
    <brief_title>Improving Grasp Function in People With Sensorimotor Impairments by Combining Electrical Stimulation With a Robotic Hand Orthosis</brief_title>
    <acronym>SENSIBLE-EXO</acronym>
    <official_title>Improving Grasp Function in People With Sensorimotor Impairments by Combining Electrical Stimulation With a Robotic Hand Orthosis</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Andrea Cimolato</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>ETH Zurich</source>
    <oversight_info>
      <has_dmc>No</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        Hand motor and sensory impairments resulting from neurological disorders or injuries affect&#xD;
        more than 50 million individuals worldwide. Conditions such as stroke, spinal cord injury&#xD;
        (SCI), and traumatic brain injury (TBI) can cause long-term hand impairments, greatly&#xD;
        impacting daily activities and social integration. Since traditional physiotherapy has&#xD;
        limited effectiveness in rehabilitation, assistive devices helping in performing in daily&#xD;
        activities have emerged as a necessary solution. Soft exoskeletons offer advantages as they&#xD;
        are more comfortable and adaptable for the user, but they often struggle to generate&#xD;
        sufficient force. On the other hand, electrical stimulation garments, like e-sleeves, show&#xD;
        promise by stimulating nerves and muscles in the forearm. However, achieving precise and&#xD;
        stable movement control remains challenging due to difficulties in electrode placement for&#xD;
        targeted stimulation. Furthermore, none of the currently available devices are capable of&#xD;
        artificially restoring lost sensation in users' hands, limiting their ability to manipulate&#xD;
        with fragile objects.&#xD;
  &#xD;
        Recognizing these limitations, our study proposes a solution that combines a standard hand&#xD;
        soft exoskeleton with: (i) electrical stimulation to the fingers' flexor and extensor muscles&#xD;
        to generate artificial muscle contractions synchronized with the exoskeleton motion,&#xD;
        compensating for the lack of gripping force, and (ii) electrical stimulation to the nerves to&#xD;
        artificially restore the lost sensation of touch, enabling users to receive feedback on the&#xD;
        force they are applying when interacting with the environment. The investigators refer to&#xD;
        this proposed combination as Sensible-Exo.&#xD;
  &#xD;
        To achieve this goal, our project aims to evaluate the functional improvements in assistive&#xD;
        and rehabilitative scenarios using SensoExo in comparison to use only the exoskeleton or&#xD;
        having no support at all. The exoskeleton will be coupled with an electrical stimulating&#xD;
        sleeve capable of delivering non-invasive electrical stimulation in the form of Functional&#xD;
        Electrical Stimulation (FES) and Transcutaneous Electrical Nerve Stimulation (TENS). A glove&#xD;
        with embedded force and bending sensors will be used to modulate the electrical stimulation.&#xD;
        Additionally, apart from studying the enhancement of functional tasks, the investigators will&#xD;
        explore improvements in body perception, representation, and multi-sensory integration.&#xD;
        Indeed, the investigators also aim at identifying the way patients perceive their body by&#xD;
        means of ad-hoc virtual reality assessments that has been developed. Before each assessment&#xD;
        patient will perform some predefined movement in virtual reality to familiarize with it and&#xD;
        increase embodiment.&#xD;
  &#xD;
        During the study, participants will perform a range of tasks based on their residual&#xD;
        abilities, including motor tasks (e.g., grab and release, Toronto Rehabilitation Institute&#xD;
        Hand Function Test, grip force regulation test, virtual egg test), cognitive tasks (dual&#xD;
        tasks), and assessments of body representation and perception. Some of these tasks will be&#xD;
        conducted in Virtual Reality environments, both with and without active stimulation.&#xD;
      </textblock>
    </brief_summary>
    <overall_status>Recruiting</overall_status>
    <start_date type="Actual">July 1, 2023</start_date>
    <completion_date type="Anticipated">June 30, 2030</completion_date>
    <primary_completion_date type="Anticipated">June 30, 2026</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>N/A</allocation>
      <intervention_model>Single Group Assignment</intervention_model>
      <primary_purpose>Treatment</primary_purpose>
      <masking>None (Open Label)</masking>
    </study_design_info>
    <primary_outcome>
      <measure>Change in Range of Motion with electrical stimulation and without no electrical stimulation</measure>
      <time_frame>up to one month before; thorugh study completition (average 1 month); up to one month after</time_frame>
      <description>Range of motion will be measured and compared among conditions</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Change in the area with tactile feedback in the hand with electrical stimulation and with no electrical stimulation</measure>
      <time_frame>up to one month before; thorugh study completition (average 1 month); up to one month after</time_frame>
      <description>Semmes-Weinstein Monofilament Test will be used to assess the residual tactile feedback</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Change in functional tasks performance with sensory feedback and without sensory feedback quantified by the number of successful grasp and release tasks</measure>
      <time_frame>up to one month before; thorugh study completition (average 1 month); up to one month after</time_frame>
      <description>Number of successful transportation of objects over an obstacle</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Change between functional tasks with sensory feedback and with no sensory feedback in number of virtual egg successful grasping</measure>
      <time_frame>up to one month before; thorugh study completition (average 1 month); up to one month after</time_frame>
      <description>Number of successful transportations of fragile objects over an obstacle</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Change between functional tasks with sensory feedback and with no sensory feedback in grasping force</measure>
      <time_frame>up to one month before; thorugh study completition (average 1 month); up to one month after</time_frame>
      <description>Grasping forces will be assessed during functional performance of the subjects</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Change between tasks with sensory feedback and with no sensory feedback in arm joints kinemtics</measure>
      <time_frame>up to one month before; thorugh study completition (average 1 month); up to one month after</time_frame>
      <description>Joint kinematics measurements will be measured with motion capture systems during functional performance of the subjects</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Change in experienced physical, mental, and social effects</measure>
      <time_frame>up one week before first session and up one week after last session</time_frame>
      <description>Neuro-QuL measurement system will be as assessment tool</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change in Proprioceptive drift between different conditions</measure>
      <time_frame>up one week before first session and up one week after last session</time_frame>
      <description>To measure embodiment subjects will be asked after VR sessions to indicate where they feel their arm without looking at the limb in real world. This is a measure of embodiment.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change in Telescoping measures between different conditions</measure>
      <time_frame>up one week before first session and up one week after last session</time_frame>
      <description>To measure embodiment subjects will be asked after VR sessions to indicate how long they feel their arm without looking at the limb in real world. This is a measure of embodiment.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change from baseline performance between tasks accomplished with sensory feedback and with no sensory feedback in Embodiment</measure>
      <time_frame>up one week before first session and up one week after last session</time_frame>
      <description>Embodiment will be measured with questionnaires (from -3 to +3, +3 totally agrees; two questions are from 1 to 10 (to measure vividness, where 10 is max vividness) and from 1 to 100 (to measure prevalence, where 100 is max duration of the embodiment feeling))</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Measures of self-body representation</measure>
      <time_frame>up one week before first session; thorugh study completition (average 1 month); up one week after last session</time_frame>
      <description>This will be measured in virtual reality by means of ad-hoc Body Landmark test. This is a body representation measurements.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Measures of body-space representation</measure>
      <time_frame>up one week before first session; thorugh study completition (average 1 month); up one week after last session</time_frame>
      <description>This will be measured in virtual reality by means of ad-hoc Hand Peri personal Space test. This is a body representation measurements.</description>
    </secondary_outcome>
    <number_of_arms>1</number_of_arms>
    <enrollment type="Anticipated">20</enrollment>
    <condition>Stroke</condition>
    <condition>Spinal Cord Injuries</condition>
    <condition>Traumatic Brain Injury</condition>
    <arm_group>
      <arm_group_label>Experimental group</arm_group_label>
      <arm_group_type>Experimental</arm_group_type>
    </arm_group>
    <intervention>
      <intervention_type>Device</intervention_type>
      <intervention_name>SensoExo</intervention_name>
      <description>combination of sensory feedback and the use of soft exoskeleton</description>
      <arm_group_label>Experimental group</arm_group_label>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Impairment of the motor and sensory functions of the hand in chronic stage&#xD;
  &#xD;
            -  The subject should have good proximal arm function (i.e. good shoulder abduction and&#xD;
               elevation)&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Cognitive and communication deficits impairment&#xD;
  &#xD;
            -  Prior or current psychological diseases such as borderline, schizophrenia, Depression&#xD;
               or Maniac Depression&#xD;
  &#xD;
            -  Major comprehension and memory deficits&#xD;
  &#xD;
            -  Pregnancy&#xD;
  &#xD;
            -  Epilepsy&#xD;
  &#xD;
            -  Pacemaker&#xD;
  &#xD;
            -  Cybersickness&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>N/A</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Stanisa Raspopovic, PhD</last_name>
      <role>Principal Investigator</role>
      <affiliation>ETH Zurich</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Andrea Cimolato, PhD</last_name>
      <phone>+41772466601</phone>
      <email>andrea.cimolato@gmail.com</email>
    </overall_contact>
    <location>
      <facility>
        <name>Neuroengineering Lab</name>
        <address>
          <city>Zürich</city>
          <state>Zurich</state>
          <zip>8001</zip>
          <country>Switzerland</country>
        </address>
      </facility>
      <status>Recruiting</status>
      <contact>
        <last_name>Stanisa Raspopovic, PhD</last_name>
      </contact>
    </location>
    <location_countries>
      <country>Switzerland</country>
    </location_countries>
    <reference>
      <citation>Dannenbaum RM, Dykes RW. Sensory loss in the hand after sensory stroke: therapeutic rationale. Arch Phys Med Rehabil. 1988 Oct;69(10):833-9.</citation>
      <PMID>3178450</PMID>
    </reference>
    <reference>
      <citation>Carey LM, Matyas TA, Oke LE. Sensory loss in stroke patients: effective training of tactile and proprioceptive discrimination. Arch Phys Med Rehabil. 1993 Jun;74(6):602-11. doi: 10.1016/0003-9993(93)90158-7.</citation>
      <PMID>8503750</PMID>
    </reference>
    <reference>
      <citation>Finnerup NB, Johannesen IL, Fuglsang-Frederiksen A, Bach FW, Jensen TS. Sensory function in spinal cord injury patients with and without central pain. Brain. 2003 Jan;126(Pt 1):57-70. doi: 10.1093/brain/awg007.</citation>
      <PMID>12477697</PMID>
    </reference>
    <reference>
      <citation>Fujimoto ST, Longhi L, Saatman KE, Conte V, Stocchetti N, McIntosh TK. Motor and cognitive function evaluation following experimental traumatic brain injury. Neurosci Biobehav Rev. 2004 Jul;28(4):365-78. doi: 10.1016/j.neubiorev.2004.06.002. Erratum In: Neurosci Biobehav Rev. 2005 Jan;28(8):877. Conte, Valeria [added]; Stocchetti, Nino [added].</citation>
      <PMID>15341032</PMID>
    </reference>
    <reference>
      <citation>Dannenbaum RM, Jones LA. The assessment and treatment of patients who have sensory loss following cortical lesions. J Hand Ther. 1993 Apr-Jun;6(2):130-8. doi: 10.1016/s0894-1130(12)80294-8.</citation>
      <PMID>8343879</PMID>
    </reference>
    <reference>
      <citation>Kwakkel G, Kollen BJ, van der Grond J, Prevo AJ. Probability of regaining dexterity in the flaccid upper limb: impact of severity of paresis and time since onset in acute stroke. Stroke. 2003 Sep;34(9):2181-6. doi: 10.1161/01.STR.0000087172.16305.CD. Epub 2003 Aug 7.</citation>
      <PMID>12907818</PMID>
    </reference>
    <reference>
      <citation>Wade DT. Measuring arm impairment and disability after stroke. Int Disabil Stud. 1989 Apr-Jun;11(2):89-92. doi: 10.3109/03790798909166398.</citation>
      <PMID>2698395</PMID>
    </reference>
    <reference>
      <citation>Fuhrer MJ, Rintala DH, Hart KA, Clearman R, Young ME. Relationship of life satisfaction to impairment, disability, and handicap among persons with spinal cord injury living in the community. Arch Phys Med Rehabil. 1992 Jun;73(6):552-7.</citation>
      <PMID>1622304</PMID>
    </reference>
    <reference>
      <citation>Noreau L, Fougeyrollas P. Long-term consequences of spinal cord injury on social participation: the occurrence of handicap situations. Disabil Rehabil. 2000 Mar 10;22(4):170-80. doi: 10.1080/096382800296863.</citation>
      <PMID>10798305</PMID>
    </reference>
    <reference>
      <citation>Butzer T, Lambercy O, Arata J, Gassert R. Fully Wearable Actuated Soft Exoskeleton for Grasping Assistance in Everyday Activities. Soft Robot. 2021 Apr;8(2):128-143. doi: 10.1089/soro.2019.0135. Epub 2020 Jun 18.</citation>
      <PMID>32552422</PMID>
    </reference>
    <reference>
      <citation>Beekhuizen KS. New perspectives on improving upper extremity function after spinal cord injury. J Neurol Phys Ther. 2005 Sep;29(3):157-62. doi: 10.1097/01.npt.0000282248.15911.38.</citation>
      <PMID>16398948</PMID>
    </reference>
    <reference>
      <citation>Lambercy O, Dovat L, Yun H, Wee SK, Kuah CW, Chua KS, Gassert R, Milner TE, Teo CL, Burdet E. Effects of a robot-assisted training of grasp and pronation/supination in chronic stroke: a pilot study. J Neuroeng Rehabil. 2011 Nov 16;8:63. doi: 10.1186/1743-0003-8-63.</citation>
      <PMID>22087842</PMID>
    </reference>
    <reference>
      <citation>Marquez-Chin C, Popovic MR. Functional electrical stimulation therapy for restoration of motor function after spinal cord injury and stroke: a review. Biomed Eng Online. 2020 May 24;19(1):34. doi: 10.1186/s12938-020-00773-4.</citation>
      <PMID>32448143</PMID>
    </reference>
    <reference>
      <citation>Ciancibello J, King K, Meghrazi MA, Padmanaban S, Levy T, Ramdeo R, Straka M, Bouton C. Closed-loop neuromuscular electrical stimulation using feedforward-feedback control and textile electrodes to regulate grasp force in quadriplegia. Bioelectron Med. 2019 Nov 1;5:19. doi: 10.1186/s42234-019-0034-y. eCollection 2019.</citation>
      <PMID>32232108</PMID>
    </reference>
    <reference>
      <citation>Prochazka A, Gauthier M, Wieler M, Kenwell Z. The bionic glove: an electrical stimulator garment that provides controlled grasp and hand opening in quadriplegia. Arch Phys Med Rehabil. 1997 Jun;78(6):608-14. doi: 10.1016/s0003-9993(97)90426-3.</citation>
      <PMID>9196468</PMID>
    </reference>
    <verification_date>July 2023</verification_date>
    <study_first_submitted>July 19, 2023</study_first_submitted>
    <study_first_submitted_qc>July 27, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 4, 2023</study_first_posted>
    <last_update_submitted>July 27, 2023</last_update_submitted>
    <last_update_submitted_qc>July 27, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">August 4, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Sponsor-Investigator</responsible_party_type>
      <investigator_affiliation>ETH Zurich</investigator_affiliation>
      <investigator_full_name>Andrea Cimolato</investigator_full_name>
      <investigator_title>Study coordinator</investigator_title>
    </responsible_party>
    <keyword>sensorimotor</keyword>
    <keyword>TENS</keyword>
    <keyword>FES</keyword>
    <keyword>exoskeleton</keyword>
    <keyword>wearable robotics</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Brain Injuries</mesh_term>
      <mesh_term>Spinal Cord Injuries</mesh_term>
      <mesh_term>Brain Injuries, Traumatic</mesh_term>
      <mesh_term>Wounds and Injuries</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT05976087
  org study id: 1-010428
  nct id: NCT05976087
  lead sponsor: 
  has dmc: No
  is fda regulated drug: No
  is fda regulated device: No
  Hand motor and sensory impairments resulting from neurological disorders or injuries affect
        more than 50 million individuals worldwide. Conditions such as stroke, spinal cord injury
        (SCI), and traumatic brain injury (TBI) can cause long-term hand impairments, greatly
        impacting daily activities and social integration. Since traditional physiotherapy has
        limited effectiveness in rehabilitation, assistive devices helping in performing in daily
        activities have emerged as a necessary solution. Soft exoskeletons offer advantages as they
        are more comfortable and adaptable for the user, but they often struggle to generate
        sufficient force. On the other hand, electrical stimulation garments, like e-sleeves, show
        promise by stimulating nerves and muscles in the forearm. However, achieving precise and
        stable movement control remains challenging due to difficulties in electrode placement for
        targeted stimulation. Furthermore, none of the currently available devices are capable of
        artificially restoring lost sensation in users' hands, limiting their ability to manipulate
        with fragile objects.
  
        Recognizing these limitations, our study proposes a solution that combines a standard hand
        soft exoskeleton with: (i) electrical stimulation to the fingers' flexor and extensor muscles
        to generate artificial muscle contractions synchronized with the exoskeleton motion,
        compensating for the lack of gripping force, and (ii) electrical stimulation to the nerves to
        artificially restore the lost sensation of touch, enabling users to receive feedback on the
        force they are applying when interacting with the environment. The investigators refer to
        this proposed combination as Sensible-Exo.
  
        To achieve this goal, our project aims to evaluate the functional improvements in assistive
        and rehabilitative scenarios using SensoExo in comparison to use only the exoskeleton or
        having no support at all. The exoskeleton will be coupled with an electrical stimulating
        sleeve capable of delivering non-invasive electrical stimulation in the form of Functional
        Electrical Stimulation (FES) and Transcutaneous Electrical Nerve Stimulation (TENS). A glove
        with embedded force and bending sensors will be used to modulate the electrical stimulation.
        Additionally, apart from studying the enhancement of functional tasks, the investigators will
        explore improvements in body perception, representation, and multi-sensory integration.
        Indeed, the investigators also aim at identifying the way patients perceive their body by
        means of ad-hoc virtual reality assessments that has been developed. Before each assessment
        patient will perform some predefined movement in virtual reality to familiarize with it and
        increase embodiment.
  
        During the study, participants will perform a range of tasks based on their residual
        abilities, including motor tasks (e.g., grab and release, Toronto Rehabilitation Institute
        Hand Function Test, grip force regulation test, virtual egg test), cognitive tasks (dual
        tasks), and assessments of body representation and perception. Some of these tasks will be
        conducted in Virtual Reality environments, both with and without active stimulation.
  allocation: N/A
  intervention model: Single Group Assignment
  primary purpose: Treatment
  masking: None (Open Label)
  measure: Change in Range of Motion with electrical stimulation and without no electrical stimulation
  time frame: up to one month before; thorugh study completition (average 1 month); up to one month after
  description: Range of motion will be measured and compared among conditions
  measure: Change in the area with tactile feedback in the hand with electrical stimulation and with no electrical stimulation
  time frame: up to one month before; thorugh study completition (average 1 month); up to one month after
  description: Semmes-Weinstein Monofilament Test will be used to assess the residual tactile feedback
  measure: Change in functional tasks performance with sensory feedback and without sensory feedback quantified by the number of successful grasp and release tasks
  time frame: up to one month before; thorugh study completition (average 1 month); up to one month after
  description: Number of successful transportation of objects over an obstacle
  measure: Change between functional tasks with sensory feedback and with no sensory feedback in number of virtual egg successful grasping
  time frame: up to one month before; thorugh study completition (average 1 month); up to one month after
  description: Number of successful transportations of fragile objects over an obstacle
  measure: Change between functional tasks with sensory feedback and with no sensory feedback in grasping force
  time frame: up to one month before; thorugh study completition (average 1 month); up to one month after
  description: Grasping forces will be assessed during functional performance of the subjects
  measure: Change between tasks with sensory feedback and with no sensory feedback in arm joints kinemtics
  time frame: up to one month before; thorugh study completition (average 1 month); up to one month after
  description: Joint kinematics measurements will be measured with motion capture systems during functional performance of the subjects
  measure: Change in experienced physical, mental, and social effects
  time frame: up one week before first session and up one week after last session
  description: Neuro-QuL measurement system will be as assessment tool
  measure: Change in Proprioceptive drift between different conditions
  time frame: up one week before first session and up one week after last session
  description: To measure embodiment subjects will be asked after VR sessions to indicate where they feel their arm without looking at the limb in real world. This is a measure of embodiment.
  measure: Change in Telescoping measures between different conditions
  time frame: up one week before first session and up one week after last session
  description: To measure embodiment subjects will be asked after VR sessions to indicate how long they feel their arm without looking at the limb in real world. This is a measure of embodiment.
  measure: Change from baseline performance between tasks accomplished with sensory feedback and with no sensory feedback in Embodiment
  time frame: up one week before first session and up one week after last session
  description: Embodiment will be measured with questionnaires (from -3 to +3, +3 totally agrees; two questions are from 1 to 10 (to measure vividness, where 10 is max vividness) and from 1 to 100 (to measure prevalence, where 100 is max duration of the embodiment feeling))
  measure: Measures of self-body representation
  time frame: up one week before first session; thorugh study completition (average 1 month); up one week after last session
  description: This will be measured in virtual reality by means of ad-hoc Body Landmark test. This is a body representation measurements.
  measure: Measures of body-space representation
  time frame: up one week before first session; thorugh study completition (average 1 month); up one week after last session
  description: This will be measured in virtual reality by means of ad-hoc Hand Peri personal Space test. This is a body representation measurements.
  arm group label: Experimental group
  arm group type: Experimental
  intervention type: Device
  intervention name: SensoExo
  description: combination of sensory feedback and the use of soft exoskeleton
  arm group label: Experimental group
  criteria: 
  gender: All
  minimum age: 18 Years
  maximum age: N/A
  healthy volunteers: No
  last name: Stanisa Raspopovic, PhD
  role: Principal Investigator
  affiliation: ETH Zurich
  last name: Andrea Cimolato, PhD
  phone: +41772466601
  email: andrea.cimolato@gmail.com
  facility: 
  status: Recruiting
  contact: 
  country: Switzerland
  citation: Dannenbaum RM, Dykes RW. Sensory loss in the hand after sensory stroke: therapeutic rationale. Arch Phys Med Rehabil. 1988 Oct;69(10):833-9.
  PMID: 3178450
  citation: Carey LM, Matyas TA, Oke LE. Sensory loss in stroke patients: effective training of tactile and proprioceptive discrimination. Arch Phys Med Rehabil. 1993 Jun;74(6):602-11. doi: 10.1016/0003-9993(93)90158-7.
  PMID: 8503750
  citation: Finnerup NB, Johannesen IL, Fuglsang-Frederiksen A, Bach FW, Jensen TS. Sensory function in spinal cord injury patients with and without central pain. Brain. 2003 Jan;126(Pt 1):57-70. doi: 10.1093/brain/awg007.
  PMID: 12477697
  citation: Fujimoto ST, Longhi L, Saatman KE, Conte V, Stocchetti N, McIntosh TK. Motor and cognitive function evaluation following experimental traumatic brain injury. Neurosci Biobehav Rev. 2004 Jul;28(4):365-78. doi: 10.1016/j.neubiorev.2004.06.002. Erratum In: Neurosci Biobehav Rev. 2005 Jan;28(8):877. Conte, Valeria [added]; Stocchetti, Nino [added].
  PMID: 15341032
  citation: Dannenbaum RM, Jones LA. The assessment and treatment of patients who have sensory loss following cortical lesions. J Hand Ther. 1993 Apr-Jun;6(2):130-8. doi: 10.1016/s0894-1130(12)80294-8.
  PMID: 8343879
  citation: Kwakkel G, Kollen BJ, van der Grond J, Prevo AJ. Probability of regaining dexterity in the flaccid upper limb: impact of severity of paresis and time since onset in acute stroke. Stroke. 2003 Sep;34(9):2181-6. doi: 10.1161/01.STR.0000087172.16305.CD. Epub 2003 Aug 7.
  PMID: 12907818
  citation: Wade DT. Measuring arm impairment and disability after stroke. Int Disabil Stud. 1989 Apr-Jun;11(2):89-92. doi: 10.3109/03790798909166398.
  PMID: 2698395
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  responsible party type: Sponsor-Investigator
  investigator affiliation: ETH Zurich
  investigator full name: Andrea Cimolato
  investigator title: Study coordinator
  mesh term: Brain Injuries
  mesh term: Spinal Cord Injuries
  mesh term: Brain Injuries, Traumatic
  mesh term: Wounds and Injuries
  sharing ipd: No