xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT06020469</url>
    </required_header>
    <id_info>
      <org_study_id>GD2HMZK</org_study_id>
      <nct_id>NCT06020469</nct_id>
    </id_info>
    <brief_title>Comparative Effects of Ciprofol and Propofol on Pain Intensity on the First Day After Surgery: a Retrospective, Propensity Score Matched, Cohort Study</brief_title>
    <official_title>Comparative Effects of Ciprofol and Propofol on Pain Intensity of the Patients Without PCA on the First Day After Surgery: a Retrospective, Propensity Score Matched, Cohort Study</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Guangdong Second Provincial General Hospital</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Guangdong Second Provincial General Hospital</source>
    <oversight_info>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        Data intelligence platform was widely used to facilitate the process of clinical research.&#xD;
        However, a platform that integrates natural language processing (NLP) and machine learning&#xD;
        (ML) algorithms has not been reported in perioperative medical management.&#xD;
      </textblock>
    </brief_summary>
    <overall_status>Recruiting</overall_status>
    <start_date type="Anticipated">October 2023</start_date>
    <completion_date type="Anticipated">December 2023</completion_date>
    <primary_completion_date type="Anticipated">October 2023</primary_completion_date>
    <study_type>Observational</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <observational_model>Case-Only</observational_model>
      <time_perspective>Retrospective</time_perspective>
    </study_design_info>
    <primary_outcome>
      <measure>Area under the curve</measure>
      <time_frame>October 2022 to October 2023</time_frame>
    </primary_outcome>
    <number_of_groups>2</number_of_groups>
    <enrollment type="Anticipated">6500</enrollment>
    <condition>Anesthesia</condition>
    <condition>Acute Pain</condition>
    <condition>Risk Reduction</condition>
    <arm_group>
      <arm_group_label>Numeric Rating Scale (NRS) score after surgery &lt;4</arm_group_label>
    </arm_group>
    <arm_group>
      <arm_group_label>Numeric Rating Scale (NRS) score after surgery ≥ 4</arm_group_label>
    </arm_group>
    <eligibility>
      <study_pop>
        <textblock>
          Pain assessment was used by Numeric Rating Scale (NRS) score after surgery.&#xD;
        </textblock>
      </study_pop>
      <sampling_method>Probability Sample</sampling_method>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Patients were included if they were above 18 years old, undergoing non-local&#xD;
               anesthesia surgery.&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  The basic information such gender, age, height, weight, and body mass index (BMI) were&#xD;
               missing.&#xD;
  &#xD;
            -  Patients undergoing day surgery, with a history of multiple operations, or entering&#xD;
               ICU after surgery, and losing the NRS score during movement at 24h after surgery.&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>80 Years</maximum_age>
      <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
    </eligibility>
    <overall_contact>
      <last_name>Hui Zhang</last_name>
      <phone>13719136792</phone>
      <email>zhanghui@gd2h.org.cn</email>
    </overall_contact>
    <location>
      <facility>
        <name>Guangdong Second Provincial General Hospital</name>
        <address>
          <city>Guangzhou</city>
          <state>Guangdong</state>
          <country>China</country>
        </address>
      </facility>
      <status>Recruiting</status>
      <contact>
        <last_name>ZhangHui Zhang</last_name>
        <phone>13719136792</phone>
        <email>zhanghui@gd2h.org.cn</email>
      </contact>
    </location>
    <location_countries>
      <country>China</country>
    </location_countries>
    <verification_date>August 2023</verification_date>
    <study_first_submitted>August 28, 2023</study_first_submitted>
    <study_first_submitted_qc>August 28, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 31, 2023</study_first_posted>
    <last_update_submitted>August 28, 2023</last_update_submitted>
    <last_update_submitted_qc>August 28, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">August 31, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Principal Investigator</responsible_party_type>
      <investigator_affiliation>Guangdong Second Provincial General Hospital</investigator_affiliation>
      <investigator_full_name>Hui Zhang</investigator_full_name>
      <investigator_title>associate chief physician</investigator_title>
    </responsible_party>
    <keyword>Data Platform</keyword>
    <keyword>Machine Learning</keyword>
    <keyword>Postoperative Acute Pain</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Acute Pain</mesh_term>
      <mesh_term>Pain</mesh_term>
    </condition_browse>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT06020469
  org study id: GD2HMZK
  nct id: NCT06020469
  lead sponsor: 
  is fda regulated drug: No
  is fda regulated device: No
  Data intelligence platform was widely used to facilitate the process of clinical research.
        However, a platform that integrates natural language processing (NLP) and machine learning
        (ML) algorithms has not been reported in perioperative medical management.
  observational model: Case-Only
  time perspective: Retrospective
  measure: Area under the curve
  time frame: October 2022 to October 2023
  arm group label: Numeric Rating Scale (NRS) score after surgery <4
  arm group label: Numeric Rating Scale (NRS) score after surgery ≥ 4
  study pop: 
  sampling method: Probability Sample
  criteria: 
  gender: All
  minimum age: 18 Years
  maximum age: 80 Years
  healthy volunteers: Accepts Healthy Volunteers
  last name: Hui Zhang
  phone: 13719136792
  email: zhanghui@gd2h.org.cn
  facility: 
  status: Recruiting
  contact: 
  country: China
  responsible party type: Principal Investigator
  investigator affiliation: Guangdong Second Provincial General Hospital
  investigator full name: Hui Zhang
  investigator title: associate chief physician
  mesh term: Acute Pain
  mesh term: Pain