xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT06034067</url>
    </required_header>
    <id_info>
      <org_study_id>MBRU IRB-2021-61</org_study_id>
      <nct_id>NCT06034067</nct_id>
    </id_info>
    <brief_title>Osseodensification Versus Conventional Drilling for Implant Site Preparation</brief_title>
    <official_title>Osseodensification Versus Conventional Drilling for Implant Site Preparation: a Randomized Controlled Trial</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Mohammed Bin Rashid University of Medicine and Health Sciences</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Mohammed Bin Rashid University of Medicine and Health Sciences</source>
    <oversight_info>
      <has_dmc>Yes</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        A total of 34 participants, who require replacement of an anterior or posterior single tooth&#xD;
        with dental implant, will be randomly allocated to two equal sized groups. In the control&#xD;
        group, the osteotomy site preparation will be prepared by using conventional surgical drills,&#xD;
        while the test group site preparation will involve the use of Densah™ Burs (Versah Co., LLC.,&#xD;
        USA) as per the osseodensification protocol. In addition to evaluating implant stability, the&#xD;
        trial will also report on implant and patient outcomes at various time points.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        Osseodensification technique has demonstrated increased primary stability and increased bone&#xD;
        mineral density around the osteotomy site. The implants placed into osseous densification&#xD;
        osteotomies have shown significant increase in insertion and removal torque values. This&#xD;
        technique also burnishes bone along the inner layer of the osteotomy site and create a&#xD;
        condensed layer of autografted bone along the periphery and apex of the implant. This would,&#xD;
        in turn, increase the bone-implant contact enhancing the insertion torque values, and thus,&#xD;
        primary implant stability. This new technique has not only shown increased primary implant&#xD;
        stability when compared with conventional drilling, but also, shown to have similar clinical&#xD;
        safety to conventional methods of osteotomy site preparation. Although osseodensification has&#xD;
        been reported to enhance the clinical outcomes of implants by increasing primary stability,&#xD;
        its long-term effects on implant stability measurements and implant survival rates are still&#xD;
        not clear. The purpose of the present randomized controlled trial is to evaluate the&#xD;
        stability of implants placed in sites prepared with either conventional drilling or&#xD;
        osseodensification and report on implant and patient outcomes at various time points.&#xD;
  &#xD;
        Objectives:&#xD;
  &#xD;
        The aims of the randomized controlled trial are:&#xD;
  &#xD;
          -  To evaluate implant stability as measured by implant stability quotient (ISQ).&#xD;
  &#xD;
          -  To evaluate the clinical, radiographic outcomes and implant survival rates.&#xD;
  &#xD;
          -  To evaluate the need for additional bone augmentation at the time of implant placement.&#xD;
  &#xD;
          -  To evaluate changes in peri-implant marginal bone level.&#xD;
  &#xD;
          -  To evaluate bone quality as estimated by clinicians during osteotomy preparation.&#xD;
  &#xD;
          -  To evaluate biological and technical complications during the follow-up period.&#xD;
  &#xD;
          -  To evaluate patient reported outcomes.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Recruiting</overall_status>
    <start_date type="Actual">September 1, 2022</start_date>
    <completion_date type="Anticipated">August 31, 2024</completion_date>
    <primary_completion_date type="Anticipated">December 31, 2023</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>Randomized</allocation>
      <intervention_model>Parallel Assignment</intervention_model>
      <intervention_model_description>Prospective, in which participants will be recruited and then followed up throughout a specified period of time.&#xD;
  Randomized, parallel designed, concurrent controlled trial with participants randomly allocated to either control or test groups.&#xD;
  Double-blinded as both the participants and outcome accessors of radiographic outcomes will be blinded to the intervention.</intervention_model_description>
      <primary_purpose>Treatment</primary_purpose>
      <masking>Double (Participant, Outcomes Assessor)</masking>
      <masking_description>- Double-blinded as both the participants and outcome accessors of radiographic outcomes will be blinded to the intervention.</masking_description>
    </study_design_info>
    <primary_outcome>
      <measure>Changes in Implant stability quotient (ISQ values) using resonance frequency analysis</measure>
      <time_frame>Upto 36 months</time_frame>
      <description>Resonance frequency analysis (RFA) will be used to determine stability (the level of osseointegration) in dental implants. The stability will be presented as an implant stability quotient (ISQ) value. The measurements will be recorded at time of implant placement, delivery of implant restoration (baseline), one year of implant restoration and annually up to three years using resonance frequency analysis.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Implant failure rate</measure>
      <time_frame>Upto 36 months</time_frame>
      <description>Implant failure rate will be assessed clinically after one year of implant restoration and annually up to three years.</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Changes in peri-implant marginal bone level (in mm)</measure>
      <time_frame>Upto 36 months</time_frame>
      <description>Changes in peri-implant marginal bone level will be assessed at implant placement, delivery of implant restoration (baseline), one year of implant restoration and annually up to three years using standardized peri-apical radiograph. The changes in peri-implant marginal bone levels will be recorded in millimeters</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Descriptive evaluation of biological and technical complications associated with dental implant restorations</measure>
      <time_frame>Upto 36 months</time_frame>
      <description>Descriptive evaluation of biological and technical complications will be recorded during the follow-up period</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Patient postoperative experience ( visual analogue scale )</measure>
      <time_frame>Upto 10 days</time_frame>
      <description>Patient postoperative experience will be assessed using visual analogue scale during the first week following implant placement; the scale consists of a 10cm line, with end points representing 0 ('no pain') and 10 ('unbearable/worst pain'). The participant will be asked to place a mark on he line indicating the level of pain that he/she experienced.</description>
    </secondary_outcome>
    <number_of_arms>2</number_of_arms>
    <enrollment type="Anticipated">34</enrollment>
    <condition>Dental Implant Failed</condition>
    <condition>Jaw, Edentulous, Partially</condition>
    <condition>Edentulous Alveolar Ridge</condition>
    <condition>Osseointegration Failure of Dental Implant</condition>
    <arm_group>
      <arm_group_label>Osseodensification (test) group</arm_group_label>
      <arm_group_type>Experimental</arm_group_type>
      <description>Implant site preparation will be completed using osseodensification technique where tapered multifluted burs (Densah Burs; Versah, MI, USA) will be used as per manufacturer's instructions.</description>
    </arm_group>
    <arm_group>
      <arm_group_label>Standard (control) group</arm_group_label>
      <arm_group_type>Active Comparator</arm_group_type>
      <description>Implant site preparation will be completed using conventional drilling protocol technique where standardized drills provided by Straumann (Straumann®, Institute Straumann AG, Basel, Switzerland)) will be used as per manufacturer's instructions.</description>
    </arm_group>
    <intervention>
      <intervention_type>Procedure</intervention_type>
      <intervention_name>Osseodensification osteotomy preparation</intervention_name>
      <description>The implant site will be prepared by raising a mucoperiosteal flap. Implant osteotomy will be prepared by using osseodensification technique using Versah burs and a dental implant will be placed. The flaps will then be replaced and sutured with 4/0 polyglycolic acid interrupted and mattress sutures.</description>
      <arm_group_label>Osseodensification (test) group</arm_group_label>
      <other_name>Densah® burs, Versah co., USA</other_name>
    </intervention>
    <intervention>
      <intervention_type>Procedure</intervention_type>
      <intervention_name>Standardized osteotomy preparation</intervention_name>
      <description>The implant site will be prepared by raising a mucoperiosteal flap. Implant osteotomy will be prepared by using either conventional surgical drills provided by Straumann implant systems and a dental implant will be placed. The flaps will then be replaced and sutured with 4/0 polyglycolic acid interrupted and mattress sutures.</description>
      <arm_group_label>Standard (control) group</arm_group_label>
      <other_name>Straumann® Twist Drills, Straumann, Switzerland</other_name>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Aged 18 or over.&#xD;
  &#xD;
            -  Require replacement of an anterior or posterior single tooth with dental implant.&#xD;
  &#xD;
            -  Controlled oral hygiene (full-mouth plaque and bleeding scores ≤ 25% at baseline).&#xD;
  &#xD;
            -  Good compliance and commitment to attend follow-up review appointments.&#xD;
  &#xD;
            -  Willing to provide informed consent.&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Localized / generalized periodontitis.&#xD;
  &#xD;
            -  Bone metabolic disease and/or taking medications that affect bone metabolism.&#xD;
  &#xD;
            -  Long term use of non-steroidal anti-inflammatory medications.&#xD;
  &#xD;
            -  History of malignancy, radiotherapy or chemotherapy.&#xD;
  &#xD;
            -  Pregnant or lactating women.&#xD;
  &#xD;
            -  Severe bruxism or parafunctional habits.&#xD;
  &#xD;
            -  Participants, who have controlled medical condition or smokers, will not be excluded&#xD;
               in this study&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>N/A</maximum_age>
      <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Maanas S Shah, BDS MSD CAGS</last_name>
      <role>Principal Investigator</role>
      <affiliation>Mohammed Bin Rashid University of Medicine and Health Sciences</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Maanas S Shah, BDS MSD CAGS</last_name>
      <phone>00971556102178</phone>
      <email>maanas.shah@mbru.ac.ae</email>
    </overall_contact>
    <location>
      <facility>
        <name>Dubai Dental Hospital</name>
        <address>
          <city>Dubai</city>
          <zip>505055</zip>
          <country>United Arab Emirates</country>
        </address>
      </facility>
      <status>Recruiting</status>
      <contact>
        <last_name>Senior Director</last_name>
        <phone>+971505522151</phone>
        <email>khawla.belhoul@ddh.ae</email>
      </contact>
    </location>
    <location_countries>
      <country>United Arab Emirates</country>
    </location_countries>
    <results_reference>
      <citation>Albrektsson T, Zarb GA. Current interpretations of the osseointegrated response: clinical significance. Int J Prosthodont. 1993 Mar-Apr;6(2):95-105.</citation>
      <PMID>8329101</PMID>
    </results_reference>
    <results_reference>
      <citation>Atieh MA, Alsabeeha NH, Faggion CM Jr, Duncan WJ. The frequency of peri-implant diseases: a systematic review and meta-analysis. J Periodontol. 2013 Nov;84(11):1586-98. doi: 10.1902/jop.2012.120592. Epub 2012 Dec 13.</citation>
      <PMID>23237585</PMID>
    </results_reference>
    <results_reference>
      <citation>Atsumi M, Park SH, Wang HL. Methods used to assess implant stability: current status. Int J Oral Maxillofac Implants. 2007 Sep-Oct;22(5):743-54.</citation>
      <PMID>17974108</PMID>
    </results_reference>
    <results_reference>
      <citation>Buser D, Halbritter S, Hart C, Bornstein MM, Grutter L, Chappuis V, Belser UC. Early implant placement with simultaneous guided bone regeneration following single-tooth extraction in the esthetic zone: 12-month results of a prospective study with 20 consecutive patients. J Periodontol. 2009 Jan;80(1):152-62. doi: 10.1902/jop.2009.080360.</citation>
      <PMID>19228101</PMID>
    </results_reference>
    <results_reference>
      <citation>Buser D, von Arx T, ten Bruggenkate C, Weingart D. Basic surgical principles with ITI implants. Clin Oral Implants Res. 2000;11 Suppl 1:59-68. doi: 10.1034/j.1600-0501.2000.011s1059.x.</citation>
      <PMID>11168257</PMID>
    </results_reference>
    <results_reference>
      <citation>Di Stefano DA, Perrotti V, Greco GB, Cappucci C, Arosio P, Piattelli A, Iezzi G. The effect of undersizing and tapping on bone to implant contact and implant primary stability: A histomorphometric study on bovine ribs. J Adv Prosthodont. 2018 Jun;10(3):227-235. doi: 10.4047/jap.2018.10.3.227. Epub 2018 Jun 12.</citation>
      <PMID>29930793</PMID>
    </results_reference>
    <results_reference>
      <citation>Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009 Nov;41(4):1149-60. doi: 10.3758/BRM.41.4.1149.</citation>
      <PMID>19897823</PMID>
    </results_reference>
    <results_reference>
      <citation>Huwais S, Meyer EG. A Novel Osseous Densification Approach in Implant Osteotomy Preparation to Increase Biomechanical Primary Stability, Bone Mineral Density, and Bone-to-Implant Contact. Int J Oral Maxillofac Implants. 2017 Jan/Feb;32(1):27-36. doi: 10.11607/jomi.4817. Epub 2016 Oct 14.</citation>
      <PMID>27741329</PMID>
    </results_reference>
    <results_reference>
      <citation>Inchingolo AD, Inchingolo AM, Bordea IR, Xhajanka E, Romeo DM, Romeo M, Zappone CMF, Malcangi G, Scarano A, Lorusso F, Isacco CG, Marinelli G, Contaldo M, Ballini A, Inchingolo F, Dipalma G. The Effectiveness of Osseodensification Drilling Protocol for Implant Site Osteotomy: A Systematic Review of the Literature and Meta-Analysis. Materials (Basel). 2021 Feb 28;14(5):1147. doi: 10.3390/ma14051147.</citation>
      <PMID>33671038</PMID>
    </results_reference>
    <results_reference>
      <citation>Javed F, Ahmed HB, Crespi R, Romanos GE. Role of primary stability for successful osseointegration of dental implants: Factors of influence and evaluation. Interv Med Appl Sci. 2013 Dec;5(4):162-7. doi: 10.1556/IMAS.5.2013.4.3. Epub 2013 Dec 20.</citation>
      <PMID>24381734</PMID>
    </results_reference>
    <results_reference>
      <citation>Lioubavina-Hack N, Lang NP, Karring T. Significance of primary stability for osseointegration of dental implants. Clin Oral Implants Res. 2006 Jun;17(3):244-50. doi: 10.1111/j.1600-0501.2005.01201.x.</citation>
      <PMID>16672018</PMID>
    </results_reference>
    <results_reference>
      <citation>Meredith N. Assessment of implant stability as a prognostic determinant. Int J Prosthodont. 1998 Sep-Oct;11(5):491-501.</citation>
      <PMID>9922740</PMID>
    </results_reference>
    <results_reference>
      <citation>Sennerby L, Meredith N. Resonance frequency analysis: measuring implant stability and osseointegration. Compend Contin Educ Dent. 1998 May;19(5):493-8, 500, 502; quiz 504.</citation>
      <PMID>9693511</PMID>
    </results_reference>
    <results_reference>
      <citation>Sennerby L, Meredith N. Implant stability measurements using resonance frequency analysis: biological and biomechanical aspects and clinical implications. Periodontol 2000. 2008;47:51-66. doi: 10.1111/j.1600-0757.2008.00267.x. No abstract available.</citation>
      <PMID>18412573</PMID>
    </results_reference>
    <results_reference>
      <citation>Trisi P, Berardini M, Falco A, Podaliri Vulpiani M. New Osseodensification Implant Site Preparation Method to Increase Bone Density in Low-Density Bone: In Vivo Evaluation in Sheep. Implant Dent. 2016 Feb;25(1):24-31. doi: 10.1097/ID.0000000000000358.</citation>
      <PMID>26584202</PMID>
    </results_reference>
    <results_reference>
      <citation>Trisi P, Perfetti G, Baldoni E, Berardi D, Colagiovanni M, Scogna G. Implant micromotion is related to peak insertion torque and bone density. Clin Oral Implants Res. 2009 May;20(5):467-71. doi: 10.1111/j.1600-0501.2008.01679.x.</citation>
      <PMID>19522976</PMID>
    </results_reference>
    <verification_date>September 2023</verification_date>
    <study_first_submitted>August 27, 2023</study_first_submitted>
    <study_first_submitted_qc>September 10, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">September 13, 2023</study_first_posted>
    <last_update_submitted>September 12, 2023</last_update_submitted>
    <last_update_submitted_qc>September 12, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">September 14, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Principal Investigator</responsible_party_type>
      <investigator_affiliation>Mohammed Bin Rashid University of Medicine and Health Sciences</investigator_affiliation>
      <investigator_full_name>Maanas Shah</investigator_full_name>
      <investigator_title>Lecturer</investigator_title>
    </responsible_party>
    <keyword>osseointegration</keyword>
    <keyword>bone density</keyword>
    <keyword>osteotomy</keyword>
    <keyword>primary stability</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Jaw, Edentulous</mesh_term>
      <mesh_term>Jaw, Edentulous, Partially</mesh_term>
      <mesh_term>Mouth, Edentulous</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT06034067
  org study id: MBRU IRB-2021-61
  nct id: NCT06034067
  lead sponsor: 
  has dmc: Yes
  is fda regulated drug: No
  is fda regulated device: No
  A total of 34 participants, who require replacement of an anterior or posterior single tooth
        with dental implant, will be randomly allocated to two equal sized groups. In the control
        group, the osteotomy site preparation will be prepared by using conventional surgical drills,
        while the test group site preparation will involve the use of Densah™ Burs (Versah Co., LLC.,
        USA) as per the osseodensification protocol. In addition to evaluating implant stability, the
        trial will also report on implant and patient outcomes at various time points.
  Osseodensification technique has demonstrated increased primary stability and increased bone
        mineral density around the osteotomy site. The implants placed into osseous densification
        osteotomies have shown significant increase in insertion and removal torque values. This
        technique also burnishes bone along the inner layer of the osteotomy site and create a
        condensed layer of autografted bone along the periphery and apex of the implant. This would,
        in turn, increase the bone-implant contact enhancing the insertion torque values, and thus,
        primary implant stability. This new technique has not only shown increased primary implant
        stability when compared with conventional drilling, but also, shown to have similar clinical
        safety to conventional methods of osteotomy site preparation. Although osseodensification has
        been reported to enhance the clinical outcomes of implants by increasing primary stability,
        its long-term effects on implant stability measurements and implant survival rates are still
        not clear. The purpose of the present randomized controlled trial is to evaluate the
        stability of implants placed in sites prepared with either conventional drilling or
        osseodensification and report on implant and patient outcomes at various time points.
  
        Objectives:
  
        The aims of the randomized controlled trial are:
  
          -  To evaluate implant stability as measured by implant stability quotient (ISQ).
  
          -  To evaluate the clinical, radiographic outcomes and implant survival rates.
  
          -  To evaluate the need for additional bone augmentation at the time of implant placement.
  
          -  To evaluate changes in peri-implant marginal bone level.
  
          -  To evaluate bone quality as estimated by clinicians during osteotomy preparation.
  
          -  To evaluate biological and technical complications during the follow-up period.
  
          -  To evaluate patient reported outcomes.
  allocation: Randomized
  intervention model: Parallel Assignment
  intervention model description: Prospective, in which participants will be recruited and then followed up throughout a specified period of time.
  Randomized, parallel designed, concurrent controlled trial with participants randomly allocated to either control or test groups.
  Double-blinded as both the participants and outcome accessors of radiographic outcomes will be blinded to the intervention.
  primary purpose: Treatment
  masking: Double (Participant, Outcomes Assessor)
  masking description: - Double-blinded as both the participants and outcome accessors of radiographic outcomes will be blinded to the intervention.
  measure: Changes in Implant stability quotient (ISQ values) using resonance frequency analysis
  time frame: Upto 36 months
  description: Resonance frequency analysis (RFA) will be used to determine stability (the level of osseointegration) in dental implants. The stability will be presented as an implant stability quotient (ISQ) value. The measurements will be recorded at time of implant placement, delivery of implant restoration (baseline), one year of implant restoration and annually up to three years using resonance frequency analysis.
  measure: Implant failure rate
  time frame: Upto 36 months
  description: Implant failure rate will be assessed clinically after one year of implant restoration and annually up to three years.
  measure: Changes in peri-implant marginal bone level (in mm)
  time frame: Upto 36 months
  description: Changes in peri-implant marginal bone level will be assessed at implant placement, delivery of implant restoration (baseline), one year of implant restoration and annually up to three years using standardized peri-apical radiograph. The changes in peri-implant marginal bone levels will be recorded in millimeters
  measure: Descriptive evaluation of biological and technical complications associated with dental implant restorations
  time frame: Upto 36 months
  description: Descriptive evaluation of biological and technical complications will be recorded during the follow-up period
  measure: Patient postoperative experience ( visual analogue scale )
  time frame: Upto 10 days
  description: Patient postoperative experience will be assessed using visual analogue scale during the first week following implant placement; the scale consists of a 10cm line, with end points representing 0 ('no pain') and 10 ('unbearable/worst pain'). The participant will be asked to place a mark on he line indicating the level of pain that he/she experienced.
  arm group label: Osseodensification (test) group
  arm group type: Experimental
  description: Implant site preparation will be completed using osseodensification technique where tapered multifluted burs (Densah Burs; Versah, MI, USA) will be used as per manufacturer's instructions.
  arm group label: Standard (control) group
  arm group type: Active Comparator
  description: Implant site preparation will be completed using conventional drilling protocol technique where standardized drills provided by Straumann (Straumann®, Institute Straumann AG, Basel, Switzerland)) will be used as per manufacturer's instructions.
  intervention type: Procedure
  intervention name: Osseodensification osteotomy preparation
  description: The implant site will be prepared by raising a mucoperiosteal flap. Implant osteotomy will be prepared by using osseodensification technique using Versah burs and a dental implant will be placed. The flaps will then be replaced and sutured with 4/0 polyglycolic acid interrupted and mattress sutures.
  arm group label: Osseodensification (test) group
  other name: Densah® burs, Versah co., USA
  intervention type: Procedure
  intervention name: Standardized osteotomy preparation
  description: The implant site will be prepared by raising a mucoperiosteal flap. Implant osteotomy will be prepared by using either conventional surgical drills provided by Straumann implant systems and a dental implant will be placed. The flaps will then be replaced and sutured with 4/0 polyglycolic acid interrupted and mattress sutures.
  arm group label: Standard (control) group
  other name: Straumann® Twist Drills, Straumann, Switzerland
  criteria: 
  gender: All
  minimum age: 18 Years
  maximum age: N/A
  healthy volunteers: Accepts Healthy Volunteers
  last name: Maanas S Shah, BDS MSD CAGS
  role: Principal Investigator
  affiliation: Mohammed Bin Rashid University of Medicine and Health Sciences
  last name: Maanas S Shah, BDS MSD CAGS
  phone: 00971556102178
  email: maanas.shah@mbru.ac.ae
  facility: 
  status: Recruiting
  contact: 
  country: United Arab Emirates
  citation: Albrektsson T, Zarb GA. Current interpretations of the osseointegrated response: clinical significance. Int J Prosthodont. 1993 Mar-Apr;6(2):95-105.
  PMID: 8329101
  citation: Atieh MA, Alsabeeha NH, Faggion CM Jr, Duncan WJ. The frequency of peri-implant diseases: a systematic review and meta-analysis. J Periodontol. 2013 Nov;84(11):1586-98. doi: 10.1902/jop.2012.120592. Epub 2012 Dec 13.
  PMID: 23237585
  citation: Atsumi M, Park SH, Wang HL. Methods used to assess implant stability: current status. Int J Oral Maxillofac Implants. 2007 Sep-Oct;22(5):743-54.
  PMID: 17974108
  citation: Buser D, Halbritter S, Hart C, Bornstein MM, Grutter L, Chappuis V, Belser UC. Early implant placement with simultaneous guided bone regeneration following single-tooth extraction in the esthetic zone: 12-month results of a prospective study with 20 consecutive patients. J Periodontol. 2009 Jan;80(1):152-62. doi: 10.1902/jop.2009.080360.
  PMID: 19228101
  citation: Buser D, von Arx T, ten Bruggenkate C, Weingart D. Basic surgical principles with ITI implants. Clin Oral Implants Res. 2000;11 Suppl 1:59-68. doi: 10.1034/j.1600-0501.2000.011s1059.x.
  PMID: 11168257
  citation: Di Stefano DA, Perrotti V, Greco GB, Cappucci C, Arosio P, Piattelli A, Iezzi G. The effect of undersizing and tapping on bone to implant contact and implant primary stability: A histomorphometric study on bovine ribs. J Adv Prosthodont. 2018 Jun;10(3):227-235. doi: 10.4047/jap.2018.10.3.227. Epub 2018 Jun 12.
  PMID: 29930793
  citation: Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009 Nov;41(4):1149-60. doi: 10.3758/BRM.41.4.1149.
  PMID: 19897823
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  responsible party type: Principal Investigator
  investigator affiliation: Mohammed Bin Rashid University of Medicine and Health Sciences
  investigator full name: Maanas Shah
  investigator title: Lecturer
  mesh term: Jaw, Edentulous
  mesh term: Jaw, Edentulous, Partially
  mesh term: Mouth, Edentulous
  sharing ipd: No