xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT05992402</url>
    </required_header>
    <id_info>
      <org_study_id>IRB 23-212</org_study_id>
      <nct_id>NCT05992402</nct_id>
    </id_info>
    <brief_title>Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery</brief_title>
    <acronym>ReBOOT</acronym>
    <official_title>Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Kayela Arrotta</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>The Cleveland Clinic</source>
    <oversight_info>
      <has_dmc>No</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        The goal of this clinical trial is to learn if new educational program prior to epilepsy&#xD;
        surgery can either decrease the risk of cognitive decline after surgery or be a help to those&#xD;
        patients who experience a decline after undergoing epilepsy surgery.&#xD;
  &#xD;
        Participants will participate in 2 individual virtual sessions and 4 virtual group sessions&#xD;
        over the course of 5-6 weeks prior to their epilepsy surgery. They will asked to fill out&#xD;
        online surveys and questionnaires at various times throughout the study, up to 12 months&#xD;
        after their surgery.&#xD;
  &#xD;
        To see if the educational program works, researchers will compare those participating in the&#xD;
        educational program with those that are receiving the standard epilepsy care prior to&#xD;
        surgery.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        In this prospective, controlled, randomized study, the researchers aim to assess the&#xD;
        feasibility and effectiveness of a cognitive intervention in those with epilepsy. They will&#xD;
        implement a novel prehabilitation program for patients who have been recommended for epilepsy&#xD;
        surgery and will track recruitment, retention, and adherence to understand the feasibility of&#xD;
        the program. Researchers will gather patient data regarding satisfaction with the&#xD;
        prehabilitation program and elicit qualitative feedback from patients to further refine the&#xD;
        program. To assess intervention efficacy, researchers will compare patients who undergo the&#xD;
        prehabilitation program to a treatment-as-usual control group on outcome measures related to&#xD;
        compensatory strategy use, psychosocial factors, and surgical expectations and satisfaction.&#xD;
  &#xD;
        The study team will accomplish these objectives by comparing participants that are randomly&#xD;
        assigned to the ReBOOT intervention arm (2 individual, virtual sessions and 4 virtual, group&#xD;
        sessions over the course of 5-6 weeks) to those participants assigned to the control arm&#xD;
        (standard epilepsy care). Researchers will measure the effects and feasibility of the&#xD;
        intervention through the use attendance tracking, homework adherence, and health and quality&#xD;
        of life questionnaires.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Not yet recruiting</overall_status>
    <start_date type="Anticipated">October 2023</start_date>
    <completion_date type="Anticipated">June 2028</completion_date>
    <primary_completion_date type="Anticipated">June 2028</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>Randomized</allocation>
      <intervention_model>Parallel Assignment</intervention_model>
      <primary_purpose>Treatment</primary_purpose>
      <masking>None (Open Label)</masking>
    </study_design_info>
    <primary_outcome>
      <measure>Recruitment success</measure>
      <time_frame>5-6 Weeks post study enrollment</time_frame>
      <description>As determined by number of patients contacted vs enrolled</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Intervention attendance</measure>
      <time_frame>5-6 Weeks post study enrollment</time_frame>
      <description>As determined by weekly group attendance and the number of weeks it takes each patient to complete all four rotating sessions</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Rate of Homework Completion</measure>
      <time_frame>5-6 Weeks post study enrollment</time_frame>
      <description>As determined by self-reported whether or not patient attempted to complete or completed their homework</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Study Attrition</measure>
      <time_frame>5-6 Weeks post study enrollment</time_frame>
      <description>As determined by number of patients who do not complete the ReBOOT program and the reasons why</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Intervention Efficacy based on Functional Status - Based on The Instrumental Activities of Daily Living-Compensation questionnaire score</measure>
      <time_frame>5-6 weeks post study enrollment, 6 month, 12 month</time_frame>
      <description>The Instrumental Activities of Daily Living-Compensation questionnaire (Min/Max: 27-216, higher score means worse outcome)</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Intervention Efficacy based on Functional Status - Based on The Quality of Life in Epilepsy questionnaire score</measure>
      <time_frame>5-6 weeks post study enrollment, 6 month, 12 month</time_frame>
      <description>Quality of Life in Epilepsy questionnaire (Min/Max: 0-100, higher score means better outcome)</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Change in Subjective Cognitive Function</measure>
      <time_frame>5-6 weeks post study enrollment, 6 month, 12 month</time_frame>
      <description>As assessed by the Memory Assessment Clinics Scale for Epilepsy (Min/Max: 30-150, Higher score means better outcome) and the Everyday Compensation Scale (Min/Max: 0-220, higher score means better outcome)</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change in Stress</measure>
      <time_frame>5-6 weeks post study enrollment, 6 month, 12 month</time_frame>
      <description>As assessed by the Perceived Stress Scale 4 (Min/Max: 0-16, higher score means worse outcome)</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Change in Mood</measure>
      <time_frame>5-6 weeks post study enrollment, 6 month, 12 month</time_frame>
      <description>As assessed by the Patient Health Questionnaire (Min/Max: 0-24, higher score means worse outcome) and the Generalized Anxiety Disorder (Min/Max: 0-21, higher score means worse outcome)</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Surgery Satisfaction assessed by Epilepsy Surgery Satisfaction Questionnaire</measure>
      <time_frame>6 month, 12 month</time_frame>
      <description>Min/Max: 19-133, higher score means better outcome</description>
    </secondary_outcome>
    <number_of_arms>2</number_of_arms>
    <enrollment type="Anticipated">150</enrollment>
    <condition>Epilepsy</condition>
    <arm_group>
      <arm_group_label>Intervention</arm_group_label>
      <arm_group_type>Experimental</arm_group_type>
      <description>Participants in this arm will receive 2 one-on-one virtual education sessions as well as 4 virtual group education sessions prior to their epilepsy surgery.</description>
    </arm_group>
    <arm_group>
      <arm_group_label>Treatment-as-Usual</arm_group_label>
      <arm_group_type>No Intervention</arm_group_type>
      <description>Participants in this arm will not receive the education sessions and will receive standard epilepsy care prior to their surgery.</description>
    </arm_group>
    <intervention>
      <intervention_type>Behavioral</intervention_type>
      <intervention_name>ReBOOT program</intervention_name>
      <description>This is a virtual cognitive intervention led by a clinical neuropsychologist. Participants will attend 2 one-on-one individual sessions and 4 group sessions prior to their epilepsy surgery. Groups will be made up of 3-10 participants. The intervention is designed to provide participants with information about possible changes and/or challenges they may experience after epilepsy surgery, as well as cognitive strategies to implement prior to surgery to increase effectiveness of compensation for any new cognitive difficulties that may be experienced following surgery.</description>
      <arm_group_label>Intervention</arm_group_label>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Adults, aged 18-60 years old, with diagnosed epilepsy who have been confirmed as an&#xD;
               appropriate surgical candidate by their epileptologist&#xD;
  &#xD;
            -  Able to independently provide informed consent&#xD;
  &#xD;
            -  Fluent in English&#xD;
  &#xD;
            -  Reading abilities at or above 8th grade level as determined by the Wide Range&#xD;
               Achievement Test- 4th Edition (WRAT-4), Reading subtest.&#xD;
  &#xD;
            -  Internet access and the ability to participate in online video streaming&#xD;
  &#xD;
            -  No history of neurosurgery&#xD;
  &#xD;
            -  Willing and able to participate in cognitive intervention&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Patients with a history of non-epileptic or psychogenic seizures&#xD;
  &#xD;
            -  Any patient that has engaged in any form of cognitive rehabilitation/intervention&#xD;
               within the last 6 months&#xD;
  &#xD;
            -  Pending litigation related to the cause of epilepsy or current application for long&#xD;
               term disability&#xD;
  &#xD;
            -  Undergoing intensive medical treatment for serious or life-threatening illness (e.g.,&#xD;
               chemotherapy, etc.) that would impact study participation.&#xD;
  &#xD;
            -  Serious psychiatric condition that could interfere with participation, such as&#xD;
               schizophrenia, active psychosis, active mania, and current suicidal ideation.&#xD;
  &#xD;
            -  Significant hearing and/or vision loss that would preclude them from participating in&#xD;
               remote cognitive testing and engaging in the cognitive intervention.&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>60 Years</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Kayela Arrotta, PhD</last_name>
      <role>Principal Investigator</role>
      <affiliation>The Cleveland Clinic</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Kayela Arrotta, PhD</last_name>
      <phone>216-444-6101</phone>
      <email>ArrottK@ccf.org</email>
    </overall_contact>
    <reference>
      <citation>Liu SY, Yang XL, Chen B, Hou Z, An N, Yang MH, Yang H. Clinical outcomes and quality of life following surgical treatment for refractory epilepsy: a systematic review and meta-analysis. Medicine (Baltimore). 2015 Feb;94(6):e500. doi: 10.1097/MD.0000000000000500.</citation>
      <PMID>25674741</PMID>
    </reference>
    <reference>
      <citation>Sherman EM, Wiebe S, Fay-McClymont TB, Tellez-Zenteno J, Metcalfe A, Hernandez-Ronquillo L, Hader WJ, Jette N. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia. 2011 May;52(5):857-69. doi: 10.1111/j.1528-1167.2011.03022.x. Epub 2011 Mar 22.</citation>
      <PMID>21426331</PMID>
    </reference>
    <reference>
      <citation>Busch RM, Floden DP, Ferguson L, Mahmoud S, Mullane A, Jones S, Jehi L, Bingaman W, Najm IM. Neuropsychological outcome following frontal lobectomy for pharmacoresistant epilepsy in adults. Neurology. 2017 Feb 14;88(7):692-700. doi: 10.1212/WNL.0000000000003611. Epub 2017 Jan 13.</citation>
      <PMID>28087827</PMID>
    </reference>
    <reference>
      <citation>Pauli C, Schwarzbold ML, Diaz AP, de Oliveira Thais MER, Kondageski C, Linhares MN, Guarnieri R, de Lemos Zingano B, Ben J, Nunes JC, Markowitsch HJ, Wolf P, Wiebe S, Lin K, Walz R. Predictors of meaningful improvement in quality of life after temporal lobe epilepsy surgery: A prospective study. Epilepsia. 2017 May;58(5):755-763. doi: 10.1111/epi.13721. Epub 2017 Mar 23.</citation>
      <PMID>28332703</PMID>
    </reference>
    <reference>
      <citation>Qiu Y, Zhang J, Yan Y, Liu W, Zhan S, Huang P, Deng Y. Predictors of meaningful improvement in quality of life after selective amygdalohippocampectomy in Chinese patients with refractory temporal lobe epilepsy: A prospective study. Epilepsy Behav. 2019 Aug;97:1-7. doi: 10.1016/j.yebeh.2019.05.006. Epub 2019 Jun 7.</citation>
      <PMID>31181423</PMID>
    </reference>
    <reference>
      <citation>Farina E, Raglio A, Giovagnoli AR. Cognitive rehabilitation in epilepsy: An evidence-based review. Epilepsy Res. 2015 Jan;109:210-8. doi: 10.1016/j.eplepsyres.2014.10.017. Epub 2014 Nov 6.</citation>
      <PMID>25524861</PMID>
    </reference>
    <reference>
      <citation>Streltzov NA, Schmidt SS, Schommer LM, Zhao W, Tosteson TD, Mazanec MT, Kiriakopoulos ET, Chu F, Henninger HL, Nagle K, Roth RM, Jobst B. Effectiveness of a Self-Management Program to Improve Cognition and Quality of Life in Epilepsy: A Pragmatic, Randomized, Multicenter Trial. Neurology. 2022 May 24;98(21):e2174-e2184. doi: 10.1212/WNL.0000000000200346. Epub 2022 Apr 6.</citation>
      <PMID>35387855</PMID>
    </reference>
    <reference>
      <citation>Baxendale S. Cognitive rehabilitation and prehabilitation in people with epilepsy. Epilepsy Behav. 2020 May;106:107027. doi: 10.1016/j.yebeh.2020.107027. Epub 2020 Mar 21.</citation>
      <PMID>32208338</PMID>
    </reference>
    <reference>
      <citation>Rodakowski J, Saghafi E, Butters MA, Skidmore ER. Non-pharmacological interventions for adults with mild cognitive impairment and early stage dementia: An updated scoping review. Mol Aspects Med. 2015 Jun-Oct;43-44:38-53. doi: 10.1016/j.mam.2015.06.003. Epub 2015 Jun 10.</citation>
      <PMID>26070444</PMID>
    </reference>
    <reference>
      <citation>Daksla N, Nguyen V, Jin Z, Bergese SD. Brain Prehabilitation for Oncologic Surgery. Curr Oncol Rep. 2022 Nov;24(11):1513-1520. doi: 10.1007/s11912-022-01312-1. Epub 2022 Jul 28.</citation>
      <PMID>35900715</PMID>
    </reference>
    <reference>
      <citation>Humeidan ML, Reyes JC, Mavarez-Martinez A, Roeth C, Nguyen CM, Sheridan E, Zuleta-Alarcon A, Otey A, Abdel-Rasoul M, Bergese SD. Effect of Cognitive Prehabilitation on the Incidence of Postoperative Delirium Among Older Adults Undergoing Major Noncardiac Surgery: The Neurobics Randomized Clinical Trial. JAMA Surg. 2021 Feb 1;156(2):148-156. doi: 10.1001/jamasurg.2020.4371.</citation>
      <PMID>33175114</PMID>
    </reference>
    <reference>
      <citation>McCann M, Stamp N, Ngui A, Litton E. Cardiac Prehabilitation. J Cardiothorac Vasc Anesth. 2019 Aug;33(8):2255-2265. doi: 10.1053/j.jvca.2019.01.023. Epub 2019 Jan 12.</citation>
      <PMID>30765210</PMID>
    </reference>
    <reference>
      <citation>Smith NA, Martin G, Marginson B. Preoperative assessment and prehabilitation in patients with obesity undergoing non-bariatric surgery: A systematic review. J Clin Anesth. 2022 Jun;78:110676. doi: 10.1016/j.jclinane.2022.110676. Epub 2022 Feb 10.</citation>
      <PMID>35152081</PMID>
    </reference>
    <reference>
      <citation>Garcia-Delgado Y, Lopez-Madrazo-Hernandez MJ, Alvarado-Martel D, Miranda-Calderin G, Ugarte-Lopetegui A, Gonzalez-Medina RA, Hernandez-Lazaro A, Zamora G, Perez-Martin N, Sanchez-Hernandez RM, Ibarra-Gonzalez A, Bengoa-Dolon M, Mendoza-Vega CT, Appelvik-Gonzalez SM, Caballero-Diaz Y, Hernandez-Hernandez JR, Wagner AM. Prehabilitation for Bariatric Surgery: A Randomized, Controlled Trial Protocol and Pilot Study. Nutrients. 2021 Aug 24;13(9):2903. doi: 10.3390/nu13092903.</citation>
      <PMID>34578781</PMID>
    </reference>
    <verification_date>September 2023</verification_date>
    <study_first_submitted>July 24, 2023</study_first_submitted>
    <study_first_submitted_qc>August 7, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 15, 2023</study_first_posted>
    <last_update_submitted>September 11, 2023</last_update_submitted>
    <last_update_submitted_qc>September 11, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">September 13, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Sponsor-Investigator</responsible_party_type>
      <investigator_affiliation>The Cleveland Clinic</investigator_affiliation>
      <investigator_full_name>Kayela Arrotta</investigator_full_name>
      <investigator_title>Principal Investigator</investigator_title>
    </responsible_party>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Epilepsy</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT05992402
  org study id: IRB 23-212
  nct id: NCT05992402
  lead sponsor: 
  has dmc: No
  is fda regulated drug: No
  is fda regulated device: No
  The goal of this clinical trial is to learn if new educational program prior to epilepsy
        surgery can either decrease the risk of cognitive decline after surgery or be a help to those
        patients who experience a decline after undergoing epilepsy surgery.
  
        Participants will participate in 2 individual virtual sessions and 4 virtual group sessions
        over the course of 5-6 weeks prior to their epilepsy surgery. They will asked to fill out
        online surveys and questionnaires at various times throughout the study, up to 12 months
        after their surgery.
  
        To see if the educational program works, researchers will compare those participating in the
        educational program with those that are receiving the standard epilepsy care prior to
        surgery.
  In this prospective, controlled, randomized study, the researchers aim to assess the
        feasibility and effectiveness of a cognitive intervention in those with epilepsy. They will
        implement a novel prehabilitation program for patients who have been recommended for epilepsy
        surgery and will track recruitment, retention, and adherence to understand the feasibility of
        the program. Researchers will gather patient data regarding satisfaction with the
        prehabilitation program and elicit qualitative feedback from patients to further refine the
        program. To assess intervention efficacy, researchers will compare patients who undergo the
        prehabilitation program to a treatment-as-usual control group on outcome measures related to
        compensatory strategy use, psychosocial factors, and surgical expectations and satisfaction.
  
        The study team will accomplish these objectives by comparing participants that are randomly
        assigned to the ReBOOT intervention arm (2 individual, virtual sessions and 4 virtual, group
        sessions over the course of 5-6 weeks) to those participants assigned to the control arm
        (standard epilepsy care). Researchers will measure the effects and feasibility of the
        intervention through the use attendance tracking, homework adherence, and health and quality
        of life questionnaires.
  allocation: Randomized
  intervention model: Parallel Assignment
  primary purpose: Treatment
  masking: None (Open Label)
  measure: Recruitment success
  time frame: 5-6 Weeks post study enrollment
  description: As determined by number of patients contacted vs enrolled
  measure: Intervention attendance
  time frame: 5-6 Weeks post study enrollment
  description: As determined by weekly group attendance and the number of weeks it takes each patient to complete all four rotating sessions
  measure: Rate of Homework Completion
  time frame: 5-6 Weeks post study enrollment
  description: As determined by self-reported whether or not patient attempted to complete or completed their homework
  measure: Study Attrition
  time frame: 5-6 Weeks post study enrollment
  description: As determined by number of patients who do not complete the ReBOOT program and the reasons why
  measure: Intervention Efficacy based on Functional Status - Based on The Instrumental Activities of Daily Living-Compensation questionnaire score
  time frame: 5-6 weeks post study enrollment, 6 month, 12 month
  description: The Instrumental Activities of Daily Living-Compensation questionnaire (Min/Max: 27-216, higher score means worse outcome)
  measure: Intervention Efficacy based on Functional Status - Based on The Quality of Life in Epilepsy questionnaire score
  time frame: 5-6 weeks post study enrollment, 6 month, 12 month
  description: Quality of Life in Epilepsy questionnaire (Min/Max: 0-100, higher score means better outcome)
  measure: Change in Subjective Cognitive Function
  time frame: 5-6 weeks post study enrollment, 6 month, 12 month
  description: As assessed by the Memory Assessment Clinics Scale for Epilepsy (Min/Max: 30-150, Higher score means better outcome) and the Everyday Compensation Scale (Min/Max: 0-220, higher score means better outcome)
  measure: Change in Stress
  time frame: 5-6 weeks post study enrollment, 6 month, 12 month
  description: As assessed by the Perceived Stress Scale 4 (Min/Max: 0-16, higher score means worse outcome)
  measure: Change in Mood
  time frame: 5-6 weeks post study enrollment, 6 month, 12 month
  description: As assessed by the Patient Health Questionnaire (Min/Max: 0-24, higher score means worse outcome) and the Generalized Anxiety Disorder (Min/Max: 0-21, higher score means worse outcome)
  measure: Surgery Satisfaction assessed by Epilepsy Surgery Satisfaction Questionnaire
  time frame: 6 month, 12 month
  description: Min/Max: 19-133, higher score means better outcome
  arm group label: Intervention
  arm group type: Experimental
  description: Participants in this arm will receive 2 one-on-one virtual education sessions as well as 4 virtual group education sessions prior to their epilepsy surgery.
  arm group label: Treatment-as-Usual
  arm group type: No Intervention
  description: Participants in this arm will not receive the education sessions and will receive standard epilepsy care prior to their surgery.
  intervention type: Behavioral
  intervention name: ReBOOT program
  description: This is a virtual cognitive intervention led by a clinical neuropsychologist. Participants will attend 2 one-on-one individual sessions and 4 group sessions prior to their epilepsy surgery. Groups will be made up of 3-10 participants. The intervention is designed to provide participants with information about possible changes and/or challenges they may experience after epilepsy surgery, as well as cognitive strategies to implement prior to surgery to increase effectiveness of compensation for any new cognitive difficulties that may be experienced following surgery.
  arm group label: Intervention
  criteria: 
  gender: All
  minimum age: 18 Years
  maximum age: 60 Years
  healthy volunteers: No
  last name: Kayela Arrotta, PhD
  role: Principal Investigator
  affiliation: The Cleveland Clinic
  last name: Kayela Arrotta, PhD
  phone: 216-444-6101
  email: ArrottK@ccf.org
  citation: Liu SY, Yang XL, Chen B, Hou Z, An N, Yang MH, Yang H. Clinical outcomes and quality of life following surgical treatment for refractory epilepsy: a systematic review and meta-analysis. Medicine (Baltimore). 2015 Feb;94(6):e500. doi: 10.1097/MD.0000000000000500.
  PMID: 25674741
  citation: Sherman EM, Wiebe S, Fay-McClymont TB, Tellez-Zenteno J, Metcalfe A, Hernandez-Ronquillo L, Hader WJ, Jette N. Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates. Epilepsia. 2011 May;52(5):857-69. doi: 10.1111/j.1528-1167.2011.03022.x. Epub 2011 Mar 22.
  PMID: 21426331
  citation: Busch RM, Floden DP, Ferguson L, Mahmoud S, Mullane A, Jones S, Jehi L, Bingaman W, Najm IM. Neuropsychological outcome following frontal lobectomy for pharmacoresistant epilepsy in adults. Neurology. 2017 Feb 14;88(7):692-700. doi: 10.1212/WNL.0000000000003611. Epub 2017 Jan 13.
  PMID: 28087827
  citation: Pauli C, Schwarzbold ML, Diaz AP, de Oliveira Thais MER, Kondageski C, Linhares MN, Guarnieri R, de Lemos Zingano B, Ben J, Nunes JC, Markowitsch HJ, Wolf P, Wiebe S, Lin K, Walz R. Predictors of meaningful improvement in quality of life after temporal lobe epilepsy surgery: A prospective study. Epilepsia. 2017 May;58(5):755-763. doi: 10.1111/epi.13721. Epub 2017 Mar 23.
  PMID: 28332703
  citation: Qiu Y, Zhang J, Yan Y, Liu W, Zhan S, Huang P, Deng Y. Predictors of meaningful improvement in quality of life after selective amygdalohippocampectomy in Chinese patients with refractory temporal lobe epilepsy: A prospective study. Epilepsy Behav. 2019 Aug;97:1-7. doi: 10.1016/j.yebeh.2019.05.006. Epub 2019 Jun 7.
  PMID: 31181423
  citation: Farina E, Raglio A, Giovagnoli AR. Cognitive rehabilitation in epilepsy: An evidence-based review. Epilepsy Res. 2015 Jan;109:210-8. doi: 10.1016/j.eplepsyres.2014.10.017. Epub 2014 Nov 6.
  PMID: 25524861
  citation: Streltzov NA, Schmidt SS, Schommer LM, Zhao W, Tosteson TD, Mazanec MT, Kiriakopoulos ET, Chu F, Henninger HL, Nagle K, Roth RM, Jobst B. Effectiveness of a Self-Management Program to Improve Cognition and Quality of Life in Epilepsy: A Pragmatic, Randomized, Multicenter Trial. Neurology. 2022 May 24;98(21):e2174-e2184. doi: 10.1212/WNL.0000000000200346. Epub 2022 Apr 6.
  PMID: 35387855
  citation: Baxendale S. Cognitive rehabilitation and prehabilitation in people with epilepsy. Epilepsy Behav. 2020 May;106:107027. doi: 10.1016/j.yebeh.2020.107027. Epub 2020 Mar 21.
  PMID: 32208338
  citation: Rodakowski J, Saghafi E, Butters MA, Skidmore ER. Non-pharmacological interventions for adults with mild cognitive impairment and early stage dementia: An updated scoping review. Mol Aspects Med. 2015 Jun-Oct;43-44:38-53. doi: 10.1016/j.mam.2015.06.003. Epub 2015 Jun 10.
  PMID: 26070444
  citation: Daksla N, Nguyen V, Jin Z, Bergese SD. Brain Prehabilitation for Oncologic Surgery. Curr Oncol Rep. 2022 Nov;24(11):1513-1520. doi: 10.1007/s11912-022-01312-1. Epub 2022 Jul 28.
  PMID: 35900715
  citation: Humeidan ML, Reyes JC, Mavarez-Martinez A, Roeth C, Nguyen CM, Sheridan E, Zuleta-Alarcon A, Otey A, Abdel-Rasoul M, Bergese SD. Effect of Cognitive Prehabilitation on the Incidence of Postoperative Delirium Among Older Adults Undergoing Major Noncardiac Surgery: The Neurobics Randomized Clinical Trial. JAMA Surg. 2021 Feb 1;156(2):148-156. doi: 10.1001/jamasurg.2020.4371.
  PMID: 33175114
  citation: McCann M, Stamp N, Ngui A, Litton E. Cardiac Prehabilitation. J Cardiothorac Vasc Anesth. 2019 Aug;33(8):2255-2265. doi: 10.1053/j.jvca.2019.01.023. Epub 2019 Jan 12.
  PMID: 30765210
  citation: Smith NA, Martin G, Marginson B. Preoperative assessment and prehabilitation in patients with obesity undergoing non-bariatric surgery: A systematic review. J Clin Anesth. 2022 Jun;78:110676. doi: 10.1016/j.jclinane.2022.110676. Epub 2022 Feb 10.
  PMID: 35152081
  citation: Garcia-Delgado Y, Lopez-Madrazo-Hernandez MJ, Alvarado-Martel D, Miranda-Calderin G, Ugarte-Lopetegui A, Gonzalez-Medina RA, Hernandez-Lazaro A, Zamora G, Perez-Martin N, Sanchez-Hernandez RM, Ibarra-Gonzalez A, Bengoa-Dolon M, Mendoza-Vega CT, Appelvik-Gonzalez SM, Caballero-Diaz Y, Hernandez-Hernandez JR, Wagner AM. Prehabilitation for Bariatric Surgery: A Randomized, Controlled Trial Protocol and Pilot Study. Nutrients. 2021 Aug 24;13(9):2903. doi: 10.3390/nu13092903.
  PMID: 34578781
  responsible party type: Sponsor-Investigator
  investigator affiliation: The Cleveland Clinic
  investigator full name: Kayela Arrotta
  investigator title: Principal Investigator
  mesh term: Epilepsy
  sharing ipd: No