xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT06000098</url>
    </required_header>
    <id_info>
      <org_study_id>ATADEK 2021-01/2</org_study_id>
      <nct_id>NCT06000098</nct_id>
    </id_info>
    <brief_title>Consol Time and Acute Kidney Injury in Robotic-assisted Prostatectomy</brief_title>
    <official_title>Effect of Console Time on the Development of Acute Kidney Injury in Robotic-assisted Laparoscopic Prostatectomy</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Acibadem University</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Acibadem University</source>
    <oversight_info>
      <has_dmc>No</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        Robotic-assisted laparoscopic prostatectomy (RALP) is the gold standard surgical technique in&#xD;
        prostate surgery. Many Robotic-laparoscopic surgical techniques also require the&#xD;
        intraoperative deep Trendelenburg position and intravenous fluid restriction during surgery.&#xD;
        However, the possible side effects of the deep Trendelenburg's position and the fluid&#xD;
        restriction on the cardiovascular and renal systems during surgery are unknown. Although the&#xD;
        Trendelenburg position is a life-saving maneuver in hypovolemic patients, it also carries&#xD;
        undesirable risks. Long console time may contribute to the development of acute kidney injury&#xD;
        (AKI) by prolonging the Trendelenburg time and the fluid-restricted time. In this study,&#xD;
        investigators aimed to demonstrate the effect of console time on the development of AKI.&#xD;
        Investigators also aimed to determine the hemodynamic risk factors that cause the development&#xD;
        of AKI in patients monitored with the pressure Recording Analytical Method (PRAM).&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        Although open surgery has been used for a long time in the treatment of prostate diseases,&#xD;
        robotic-assisted laparoscopic prostatectomy (RALP) has become more common in the last 20&#xD;
        years. The excellence in results has made the use of the robot the gold standard in prostate&#xD;
        surgery. However, the presence of two critical factors during RALP surgery still bothers&#xD;
        clinicians. The first of these is severe fluid restriction and the other is the deep&#xD;
        Trendelenburg position and pneumoperitoneum. The prolongation of the robotic console time&#xD;
        also causes the prolongation of fluid restriction and Trendelenburg time. This combination&#xD;
        may cause significant pathophysiological changes in both the renal and cardiac systems and&#xD;
        may lead to postoperative acute renal injury (AKI). AKI is a serious clinical complication&#xD;
        with increasing incidence and is associated with adverse short-term and long-term outcomes&#xD;
        worldwide, resulting in a large healthcare burden. Intraoperative advanced monitoring&#xD;
        techniques can contribute to the prevention of renal damage that may occur by providing early&#xD;
        recognition of these pathophysiological changes occurring in the renal and cardiac systems.&#xD;
  &#xD;
        The aim of our study was to determine the effect of console duration on the incidence of AKI&#xD;
        after RALP which was managed using intraoperative advanced monitoring techniques (pressure&#xD;
        recording analytical method-PRAM). In addition, this study aimed to evaluate the ability of&#xD;
        changes in hemodynamic parameters to predict the development of AKI in RALP patients who&#xD;
        underwent restrictive fluid therapy.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Not yet recruiting</overall_status>
    <start_date type="Anticipated">September 25, 2023</start_date>
    <completion_date type="Anticipated">October 16, 2023</completion_date>
    <primary_completion_date type="Anticipated">October 15, 2023</primary_completion_date>
    <study_type>Observational</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <observational_model>Case-Only</observational_model>
      <time_perspective>Prospective</time_perspective>
    </study_design_info>
    <primary_outcome>
      <measure>Console time was measured for evaluating the effect of restrictive fluid therapy and prostatic urethra anastomosis time on the development of acute kidney injury.</measure>
      <time_frame>The duration of the measurement was defined as during the surgery.</time_frame>
      <description>Console time ( minute) indicates the restrictive fluid therapy time, prostatic resection, and prostatic urethra anastomosis time.</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Stroke volume variation (SVV) was measured for evaluation of volume status</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Stroke volume variation (SVV,%), was monitored using the pressure recording analytic method. SVV is a parameter used to asses cardiac preload and fluid responsiveness.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Pulse pressure variation (PPV) was measured for evaluation of volume status</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Pulse pressure variation (PPV,%) was monitored using the pressure recording analytic method. PPV is a parameter used to asses cardiac preload and fluid responsiveness</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Cardiac power output (CPO) was measured for evaluation of cardiac power reserve</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Cardiac power output (CPO, Watt) was monitored using the pressure recording analytic method. CPO is a parameter used to asses cardiac reserve</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Cardiac index (CI) was measured for evaluating cardiac flow</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Cardiac index (CI, L/min/m2), was monitored using the pressure recording analytic method. CI is a parameter used to asses cardiac stroke volume.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Dp/Dt was measured to assess cardiac systolic function</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Dp/Dt(mmHg/msn), was monitored using the pressure recording analytic method. Dp/Dt is a parameter used to asses cardiac contractility.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Systolic arterial pressure (SAP) was measured for evaluating perfusion pressure</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Systolic arterial pressure (SAP- mm/Hg) was monitored using the pressure recording analytic method. SAP is a parameter used to assess the pressure of the arterial system during cardiac systole</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Diastolic arterial pressure (DAP) was measured for evaluating perfusion pressure</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Diastolic arterial pressure (DAP, mm/Hg) was monitored using the pressure recording analytic method. DAP is a parameter used to assess the pressure of the arterial system during cardiac diastole</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Mean arterial pressure (MAP) was measured for evaluating perfusion pressure</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Mean arterial pressure (MAP, mm/Hg) was monitored using the pressure recording analytic method. MAP is a parameter used to assess organ perfusion</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Heart rate (HR) was measured for evaluating heart ritm</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Heart rate( HR, bpm) was monitored using the pressure recording analytic method. HR is a parameter used to assess the cardiac rate</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Arterial elastance ( Ea) was measured for evaluation of cardiac afterload and arterial ton</measure>
      <time_frame>The duration of the measurement was defined from one minute before induction to the end of the surgery</time_frame>
      <description>Ea ((mmHg m-2ml-1) was monitored using the pressure recording analytic method. Ea is a parameter used to assess cardiac afterload and arterial tone</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>The Kidney Disease: Improving Global Outcomes (KDIGO) criteria were used for the definition and staging of acute kidney injury .</measure>
      <time_frame>The duration of the measurement was defined from the end of the surgery to the 3 days after surgery</time_frame>
      <description>KDIGO criteria ( stage) classify acute kidney injury based on changes in serum creatinine levels and urine output.</description>
    </secondary_outcome>
    <number_of_groups>1</number_of_groups>
    <enrollment type="Anticipated">50</enrollment>
    <condition>Acute Kidney Injury</condition>
    <condition>Hemodynamic Instability</condition>
    <arm_group>
      <arm_group_label>Patients undergoing robotic-assisted laparoscopic prostatectomy in deep Trendelenburg position.</arm_group_label>
      <description>Patients with ASA( American Society of Anesthesiologists) physical status 1-3 who underwent robotic-assisted laparoscopic prostatectomy in deep Trendelenburg position with restrictive fluid therapy</description>
    </arm_group>
    <intervention>
      <intervention_type>Other</intervention_type>
      <intervention_name>Restrictive fluid therapy</intervention_name>
      <description>0,5 ml/hour fluid administration during prostatic anastomosis.&#xD;
  After general anesthesia induction, the patients were placed in the deep Trendelenburg position (at least 25°-45° upside down).</description>
      <arm_group_label>Patients undergoing robotic-assisted laparoscopic prostatectomy in deep Trendelenburg position.</arm_group_label>
      <other_name>Trendelenburg position.</other_name>
    </intervention>
    <eligibility>
      <study_pop>
        <textblock>
          The patients with ASA (American Society Of Anesthesiology) physical status 1-3 who&#xD;
          underwent RALP with restrictive fluid therapy during console period&#xD;
        </textblock>
      </study_pop>
      <sampling_method>Non-Probability Sample</sampling_method>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Patients with American Society Of Anesthesiology physical status 1-3&#xD;
  &#xD;
            -  Underwent Robotic-assisted laparoscopic prostatectomy&#xD;
  &#xD;
            -  Underwent restrictive fluid therapy during the console period&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Under 18 years of age&#xD;
  &#xD;
            -  Arrhythmia (atrial fibrillation, frequent premature beat)&#xD;
  &#xD;
            -  History of myocardial infarction in the last 3 months&#xD;
  &#xD;
            -  Heart failure&#xD;
  &#xD;
            -  Severe pre-existing lung disease&#xD;
  &#xD;
            -  Severe valvular heart disease&#xD;
  &#xD;
            -  Chronic renal disease on dialysis,&#xD;
        </textblock>
      </criteria>
      <gender>Male</gender>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>100 Years</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Fevzi Toraman, M.D.</last_name>
      <role>Study Director</role>
      <affiliation>Acibadem Mehmet Ali Aydinlar University School of Medicine, Department of Anesthesiology</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Serap Aktas Yildirim, MD</last_name>
      <phone>+905325605077</phone>
      <email>serapaktas79@yahoo.com.tr</email>
    </overall_contact>
    <overall_contact_backup>
      <last_name>Zeynep T Sarikaya, M.D.</last_name>
      <email>tugcesrky@gmail.com</email>
    </overall_contact_backup>
    <location>
      <facility>
        <name>Acibadem Altunizade Hospital</name>
        <address>
          <city>Istanbul</city>
          <zip>31190</zip>
          <country>Turkey</country>
        </address>
      </facility>
    </location>
    <location_countries>
      <country>Turkey</country>
    </location_countries>
    <reference>
      <citation>Joo EY, Moon YJ, Yoon SH, Chin JH, Hwang JH, Kim YK. Comparison of Acute Kidney Injury After Robot-Assisted Laparoscopic Radical Prostatectomy Versus Retropubic Radical Prostatectomy: A Propensity Score Matching Analysis. Medicine (Baltimore). 2016 Feb;95(5):e2650. doi: 10.1097/MD.0000000000002650.</citation>
      <PMID>26844486</PMID>
    </reference>
    <reference>
      <citation>Sudfeld S, Leyh-Bannurah SR, Budaus L, Graefen M, Reese PC, von Breunig F, Reuter DA, Saugel B. Impact of perioperative administration of 6 % hydroxyethyl starch 130/0.4 on serum cystatin C-derived renal function after radical prostatectomy: a single-centre retrospective study. BMC Anesthesiol. 2016 Aug 30;16(1):69. doi: 10.1186/s12871-016-0236-8.</citation>
      <PMID>27576693</PMID>
    </reference>
    <reference>
      <citation>Lestar M, Gunnarsson L, Lagerstrand L, Wiklund P, Odeberg-Wernerman S. Hemodynamic perturbations during robot-assisted laparoscopic radical prostatectomy in 45 degrees Trendelenburg position. Anesth Analg. 2011 Nov;113(5):1069-75. doi: 10.1213/ANE.0b013e3182075d1f. Epub 2011 Jan 13.</citation>
      <PMID>21233502</PMID>
    </reference>
    <results_reference>
      <citation>Emir NS, Akyol D, Sabaz MS, Karadag S. Robotic assited perineal prostatectomy (RAPP) as a new era for anesthesiology: It's effects on hemodynamic parameters and respiratory mechanics. J Robot Surg. 2023 Jun;17(3):933-940. doi: 10.1007/s11701-022-01482-x. Epub 2022 Nov 16.</citation>
      <PMID>36383279</PMID>
    </results_reference>
    <results_reference>
      <citation>Valdivieso RF, Hueber PA, Zorn KC. Robot assisted radical prostatectomy: how I do it. Part I: Patient preparation and positioning. Can J Urol. 2013 Oct;20(5):6957-61.</citation>
      <PMID>24128839</PMID>
    </results_reference>
    <results_reference>
      <citation>Karaveli A, Kavakli AS, Cakin O, Aykal G, Yildiz A, Ates M. Comparison of plasma neutrophil gelatinase-associated lipocalin (NGAL) levels after robot-assisted laparoscopic and retropubic radical prostatectomy: an observational study. Braz J Anesthesiol. 2022 Jan-Feb;72(1):21-28. doi: 10.1016/j.bjane.2021.03.003. Epub 2021 Apr 2.</citation>
      <PMID>33819496</PMID>
    </results_reference>
    <results_reference>
      <citation>Pawlik MT, Prasser C, Zeman F, Harth M, Burger M, Denzinger S, Blecha S. Pronounced haemodynamic changes during and after robotic-assisted laparoscopic prostatectomy: a prospective observational study. BMJ Open. 2020 Oct 5;10(10):e038045. doi: 10.1136/bmjopen-2020-038045.</citation>
      <PMID>33020097</PMID>
    </results_reference>
    <verification_date>September 2023</verification_date>
    <study_first_submitted>August 11, 2023</study_first_submitted>
    <study_first_submitted_qc>August 11, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 21, 2023</study_first_posted>
    <last_update_submitted>September 15, 2023</last_update_submitted>
    <last_update_submitted_qc>September 15, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">September 18, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Sponsor</responsible_party_type>
    </responsible_party>
    <keyword>Robotic-assisted laparoscopic prostatectomy</keyword>
    <keyword>Acute kidney injury</keyword>
    <keyword>Restrictive fluid therapy</keyword>
    <keyword>Pressure recording analytical method</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Acute Kidney Injury</mesh_term>
      <mesh_term>Wounds and Injuries</mesh_term>
    </condition_browse>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT06000098
  org study id: ATADEK 2021-01/2
  nct id: NCT06000098
  lead sponsor: 
  has dmc: No
  is fda regulated drug: No
  is fda regulated device: No
  Robotic-assisted laparoscopic prostatectomy (RALP) is the gold standard surgical technique in
        prostate surgery. Many Robotic-laparoscopic surgical techniques also require the
        intraoperative deep Trendelenburg position and intravenous fluid restriction during surgery.
        However, the possible side effects of the deep Trendelenburg's position and the fluid
        restriction on the cardiovascular and renal systems during surgery are unknown. Although the
        Trendelenburg position is a life-saving maneuver in hypovolemic patients, it also carries
        undesirable risks. Long console time may contribute to the development of acute kidney injury
        (AKI) by prolonging the Trendelenburg time and the fluid-restricted time. In this study,
        investigators aimed to demonstrate the effect of console time on the development of AKI.
        Investigators also aimed to determine the hemodynamic risk factors that cause the development
        of AKI in patients monitored with the pressure Recording Analytical Method (PRAM).
  Although open surgery has been used for a long time in the treatment of prostate diseases,
        robotic-assisted laparoscopic prostatectomy (RALP) has become more common in the last 20
        years. The excellence in results has made the use of the robot the gold standard in prostate
        surgery. However, the presence of two critical factors during RALP surgery still bothers
        clinicians. The first of these is severe fluid restriction and the other is the deep
        Trendelenburg position and pneumoperitoneum. The prolongation of the robotic console time
        also causes the prolongation of fluid restriction and Trendelenburg time. This combination
        may cause significant pathophysiological changes in both the renal and cardiac systems and
        may lead to postoperative acute renal injury (AKI). AKI is a serious clinical complication
        with increasing incidence and is associated with adverse short-term and long-term outcomes
        worldwide, resulting in a large healthcare burden. Intraoperative advanced monitoring
        techniques can contribute to the prevention of renal damage that may occur by providing early
        recognition of these pathophysiological changes occurring in the renal and cardiac systems.
  
        The aim of our study was to determine the effect of console duration on the incidence of AKI
        after RALP which was managed using intraoperative advanced monitoring techniques (pressure
        recording analytical method-PRAM). In addition, this study aimed to evaluate the ability of
        changes in hemodynamic parameters to predict the development of AKI in RALP patients who
        underwent restrictive fluid therapy.
  observational model: Case-Only
  time perspective: Prospective
  measure: Console time was measured for evaluating the effect of restrictive fluid therapy and prostatic urethra anastomosis time on the development of acute kidney injury.
  time frame: The duration of the measurement was defined as during the surgery.
  description: Console time ( minute) indicates the restrictive fluid therapy time, prostatic resection, and prostatic urethra anastomosis time.
  measure: Stroke volume variation (SVV) was measured for evaluation of volume status
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Stroke volume variation (SVV,%), was monitored using the pressure recording analytic method. SVV is a parameter used to asses cardiac preload and fluid responsiveness.
  measure: Pulse pressure variation (PPV) was measured for evaluation of volume status
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Pulse pressure variation (PPV,%) was monitored using the pressure recording analytic method. PPV is a parameter used to asses cardiac preload and fluid responsiveness
  measure: Cardiac power output (CPO) was measured for evaluation of cardiac power reserve
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Cardiac power output (CPO, Watt) was monitored using the pressure recording analytic method. CPO is a parameter used to asses cardiac reserve
  measure: Cardiac index (CI) was measured for evaluating cardiac flow
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Cardiac index (CI, L/min/m2), was monitored using the pressure recording analytic method. CI is a parameter used to asses cardiac stroke volume.
  measure: Dp/Dt was measured to assess cardiac systolic function
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Dp/Dt(mmHg/msn), was monitored using the pressure recording analytic method. Dp/Dt is a parameter used to asses cardiac contractility.
  measure: Systolic arterial pressure (SAP) was measured for evaluating perfusion pressure
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Systolic arterial pressure (SAP- mm/Hg) was monitored using the pressure recording analytic method. SAP is a parameter used to assess the pressure of the arterial system during cardiac systole
  measure: Diastolic arterial pressure (DAP) was measured for evaluating perfusion pressure
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Diastolic arterial pressure (DAP, mm/Hg) was monitored using the pressure recording analytic method. DAP is a parameter used to assess the pressure of the arterial system during cardiac diastole
  measure: Mean arterial pressure (MAP) was measured for evaluating perfusion pressure
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Mean arterial pressure (MAP, mm/Hg) was monitored using the pressure recording analytic method. MAP is a parameter used to assess organ perfusion
  measure: Heart rate (HR) was measured for evaluating heart ritm
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Heart rate( HR, bpm) was monitored using the pressure recording analytic method. HR is a parameter used to assess the cardiac rate
  measure: Arterial elastance ( Ea) was measured for evaluation of cardiac afterload and arterial ton
  time frame: The duration of the measurement was defined from one minute before induction to the end of the surgery
  description: Ea ((mmHg m-2ml-1) was monitored using the pressure recording analytic method. Ea is a parameter used to assess cardiac afterload and arterial tone
  measure: The Kidney Disease: Improving Global Outcomes (KDIGO) criteria were used for the definition and staging of acute kidney injury .
  time frame: The duration of the measurement was defined from the end of the surgery to the 3 days after surgery
  description: KDIGO criteria ( stage) classify acute kidney injury based on changes in serum creatinine levels and urine output.
  arm group label: Patients undergoing robotic-assisted laparoscopic prostatectomy in deep Trendelenburg position.
  description: Patients with ASA( American Society of Anesthesiologists) physical status 1-3 who underwent robotic-assisted laparoscopic prostatectomy in deep Trendelenburg position with restrictive fluid therapy
  intervention type: Other
  intervention name: Restrictive fluid therapy
  description: 0,5 ml/hour fluid administration during prostatic anastomosis.
  After general anesthesia induction, the patients were placed in the deep Trendelenburg position (at least 25°-45° upside down).
  arm group label: Patients undergoing robotic-assisted laparoscopic prostatectomy in deep Trendelenburg position.
  other name: Trendelenburg position.
  study pop: 
  sampling method: Non-Probability Sample
  criteria: 
  gender: Male
  minimum age: 18 Years
  maximum age: 100 Years
  healthy volunteers: No
  last name: Fevzi Toraman, M.D.
  role: Study Director
  affiliation: Acibadem Mehmet Ali Aydinlar University School of Medicine, Department of Anesthesiology
  last name: Serap Aktas Yildirim, MD
  phone: +905325605077
  email: serapaktas79@yahoo.com.tr
  last name: Zeynep T Sarikaya, M.D.
  email: tugcesrky@gmail.com
  facility: 
  country: Turkey
  citation: Joo EY, Moon YJ, Yoon SH, Chin JH, Hwang JH, Kim YK. Comparison of Acute Kidney Injury After Robot-Assisted Laparoscopic Radical Prostatectomy Versus Retropubic Radical Prostatectomy: A Propensity Score Matching Analysis. Medicine (Baltimore). 2016 Feb;95(5):e2650. doi: 10.1097/MD.0000000000002650.
  PMID: 26844486
  citation: Sudfeld S, Leyh-Bannurah SR, Budaus L, Graefen M, Reese PC, von Breunig F, Reuter DA, Saugel B. Impact of perioperative administration of 6 % hydroxyethyl starch 130/0.4 on serum cystatin C-derived renal function after radical prostatectomy: a single-centre retrospective study. BMC Anesthesiol. 2016 Aug 30;16(1):69. doi: 10.1186/s12871-016-0236-8.
  PMID: 27576693
  citation: Lestar M, Gunnarsson L, Lagerstrand L, Wiklund P, Odeberg-Wernerman S. Hemodynamic perturbations during robot-assisted laparoscopic radical prostatectomy in 45 degrees Trendelenburg position. Anesth Analg. 2011 Nov;113(5):1069-75. doi: 10.1213/ANE.0b013e3182075d1f. Epub 2011 Jan 13.
  PMID: 21233502
  citation: Emir NS, Akyol D, Sabaz MS, Karadag S. Robotic assited perineal prostatectomy (RAPP) as a new era for anesthesiology: It's effects on hemodynamic parameters and respiratory mechanics. J Robot Surg. 2023 Jun;17(3):933-940. doi: 10.1007/s11701-022-01482-x. Epub 2022 Nov 16.
  PMID: 36383279
  citation: Valdivieso RF, Hueber PA, Zorn KC. Robot assisted radical prostatectomy: how I do it. Part I: Patient preparation and positioning. Can J Urol. 2013 Oct;20(5):6957-61.
  PMID: 24128839
  citation: Karaveli A, Kavakli AS, Cakin O, Aykal G, Yildiz A, Ates M. Comparison of plasma neutrophil gelatinase-associated lipocalin (NGAL) levels after robot-assisted laparoscopic and retropubic radical prostatectomy: an observational study. Braz J Anesthesiol. 2022 Jan-Feb;72(1):21-28. doi: 10.1016/j.bjane.2021.03.003. Epub 2021 Apr 2.
  PMID: 33819496
  citation: Pawlik MT, Prasser C, Zeman F, Harth M, Burger M, Denzinger S, Blecha S. Pronounced haemodynamic changes during and after robotic-assisted laparoscopic prostatectomy: a prospective observational study. BMJ Open. 2020 Oct 5;10(10):e038045. doi: 10.1136/bmjopen-2020-038045.
  PMID: 33020097
  responsible party type: Sponsor
  mesh term: Acute Kidney Injury
  mesh term: Wounds and Injuries