xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT06034587</url>
    </required_header>
    <id_info>
      <org_study_id>CQMUSAZL0619</org_study_id>
      <nct_id>NCT06034587</nct_id>
    </id_info>
    <brief_title>Multimodal Ultrasound Imaging Assessment on Keloid</brief_title>
    <official_title>A Prospective, Longitudinal, Intraindividual Clinical Study in Keloid With Multimodal Ultrasound Assessment</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Chongqing Medical University</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Chongqing Medical University</source>
    <oversight_info>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        Skin keloids are common dermatological conditions that can lead to physical limitations,&#xD;
        functional impairments, and deformities. Beyond the physiological implications, the aesthetic&#xD;
        ramifications of keloids can also result in significant psychological distress, including&#xD;
        anxiety and depression, causing both physical and emotional suffering to the affected&#xD;
        individuals. The incidence of keloids is high, characterized by their chronicity, resistance&#xD;
        to treatment, and high recurrence rate. They have become one of the most challenging&#xD;
        conditions to treat across burn surgery, plastic surgery, and dermatology disciplines. The&#xD;
        lack of standardized clinical treatment guidelines globally, combined with an absence of a&#xD;
        well-defined standardized evaluation system, means that the effectiveness of various&#xD;
        treatments is not consistently and objectively assessed, creating significant challenges in&#xD;
        clinical applications. This project integrates traditional high-frequency ultrasound with&#xD;
        cutting-edge technologies like real-time shear wave elastography and ultra-micro blood flow&#xD;
        imaging. By using multimodal ultrasound, investigators aim to observe the therapeutic&#xD;
        response of 90Sr-90Y patch treatment on skin keloids. Investigators seek to determine the&#xD;
        objectivity and quantification role of multimodal ultrasound data and indicators in assessing&#xD;
        keloid severity, including blood flow information and elasticity hardness. Another goal is to&#xD;
        obtain quantitative data on keloid thickness, volume, stiffness, and microvascular&#xD;
        distribution before and after treatment to monitor the therapy response. This would address&#xD;
        the current limitations of subjective keloid scoring scales. It would also serve as an&#xD;
        objective assessment standard for precise diagnosis, treatment, and follow-up of keloids in a&#xD;
        clinical setting, thereby standardizing the clinical diagnosis and treatment of keloids.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        Currently, no one-size-fits-all approach exists and a universally accepted, standardized&#xD;
        evaluation and treatment protocol remains elusive, making it challenging to determine which&#xD;
        method is the most effective. Commonly used methods for assessing keloids, such as the&#xD;
        Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS), rely&#xD;
        heavily on subjective evaluations based on observer perception and patient-reported&#xD;
        experiences. These methods lack objective quantitative evaluation indicators and the ability&#xD;
        to visualize subcutaneous tissues, limiting their individual clinical applicability. The&#xD;
        Vancouver Scar Scale (VSS) is the most established questionnaire used for the evaluation of&#xD;
        pathological scarring. This scale evaluates aspects of scar vascularity, pigmentation,&#xD;
        pliability, and height, with the scoring system ranging from 0 to 15, where 0 is the least&#xD;
        severe and 15 is the most severe. In the study, keloids were classified into three categories&#xD;
        based on the VSS score: mild (0-5), moderate (6-9), and severe (10-15).&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Completed</overall_status>
    <start_date type="Actual">July 21, 2021</start_date>
    <completion_date type="Actual">August 30, 2023</completion_date>
    <primary_completion_date type="Actual">August 30, 2023</primary_completion_date>
    <study_type>Observational</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <observational_model>Cohort</observational_model>
      <time_perspective>Prospective</time_perspective>
    </study_design_info>
    <primary_outcome>
      <measure>Change in stiffness measured by SWE</measure>
      <time_frame>from baseline to 6 months</time_frame>
      <description>The difference of stiffness in good response group and poor response group</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Change in microvessel signal grade measured by AP</measure>
      <time_frame>from baseline to 6 months</time_frame>
      <description>The difference of microvessel signal grade in good response group and poor response group</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Change in thickness measured by high frequency ultrasound</measure>
      <time_frame>from baseline to 6 months</time_frame>
      <description>The difference of thickness in good response group and poor response group</description>
    </primary_outcome>
    <number_of_groups>2</number_of_groups>
    <enrollment type="Actual">34</enrollment>
    <condition>Keloid</condition>
    <arm_group>
      <arm_group_label>good response group of treated keloids</arm_group_label>
      <description>The Vancouver Scar Scale (VSS) is the most established questionnaire used for the evaluation of pathological scarring. This scale evaluates aspects of scar vascularity, pigmentation, pliability, and height, with the scoring system ranging from 0 to 15, where 0 is the least severe and 15 is the most severe.All the keloids in the study were classified into three categories based on the VSS score: mild (0-5), moderate (6-9), and severe (10-15).&#xD;
  For treatment assessment, investigators further divided the treated participants into two groups: a good response group (showing an improvement of 5 or more points in the VSS score) and a poor response group (less than 5 points improvement in the VSS score)</description>
    </arm_group>
    <arm_group>
      <arm_group_label>poor response group of treated keloids</arm_group_label>
      <description>The Vancouver Scar Scale (VSS) is the most established questionnaire used for the evaluation of pathological scarring. This scale evaluates aspects of scar vascularity, pigmentation, pliability, and height, with the scoring system ranging from 0 to 15, where 0 is the least severe and 15 is the most severe. All the keloids in the study keloids were classified into three categories based on the VSS score: mild (0-5), moderate (6-9), and severe(10-15).&#xD;
  For treatment assessment, investigators further divided the treated participants into two groups: a good response group (showing an improvement of 5 or more points in the VSS score) and a poor response group (less than 5 points improvement in the VSS score)</description>
    </arm_group>
    <intervention>
      <intervention_type>Diagnostic Test</intervention_type>
      <intervention_name>multimodal ultrasound</intervention_name>
      <description>An Aixplorer ultrasound machine (SuperSonic Imaging, Ltd, Aixen-Provence, France), equipped with AngioPLUS(AP) and shear wave elastography(SWE) functions, was used for all examinations using a 4-15MHz linear probe.AP function can detect microvessels of lesions,SWE can evaluate the stiffness of lesions and high frequency ultrasound can measure the thickness and volume of keloid.</description>
      <arm_group_label>good response group of treated keloids</arm_group_label>
      <arm_group_label>poor response group of treated keloids</arm_group_label>
    </intervention>
    <intervention>
      <intervention_type>Radiation</intervention_type>
      <intervention_name>radioisotope applicator therapy</intervention_name>
      <description>The radioisotope applicator therapy utilized 90Sr-90Y(0094SR814975) isotope, customized by the China Atomic Energy Research Institute. The element therapy instrument used had overall dimensions of 2.8cm x 2.8cm, with an effective treatment area of 2.0cm x 2.0cm. It delivered a radiation dose of 5.0Gy/h. Each patient received superficial radiation therapy through a single 90Sr source, administered in repeated doses. The isotope therapy instrument was customized to fit the exact size of the keloid, ensuring coverage the irradiation range extending 0.5cm beyond the keloid's edge. During treatment, the surface of the applicator was aligned with the irradiated area and directly contact the surface of the keloid tissue. The treatment was carried out low-dose irradiation method, over 5 sessions, with each session delivering a dose of 2Gy. Each irradiation lasted for 25min.</description>
      <arm_group_label>good response group of treated keloids</arm_group_label>
      <arm_group_label>poor response group of treated keloids</arm_group_label>
    </intervention>
    <eligibility>
      <study_pop>
        <textblock>
          34 outpatients (mean age 43 ± 10.4 years, 14 male, 20 female) with untreated 63 keloids in&#xD;
          different anatomical locations and 63 corresponding normal skin sites was performed&#xD;
        </textblock>
      </study_pop>
      <sampling_method>Probability Sample</sampling_method>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Male and female patients aged 16 years and above&#xD;
  &#xD;
            -  Outpatients with no received any treatment in previous 6 months&#xD;
  &#xD;
            -  Willing to participate in this trial and have signed an informed consent form&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Pregnant or breastfeeding women&#xD;
  &#xD;
            -  patients with malignant tumors, hypertension, diabetes, skin rupture, skin infection&#xD;
               which may influence keloid healing and other dermatologic diseases&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>16 Years</minimum_age>
      <maximum_age>N/A</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Wang Zhigang</last_name>
      <role>Study Chair</role>
      <affiliation>Chongqing Medical University</affiliation>
    </overall_official>
    <location>
      <facility>
        <name>The Second Affiliated Hospital of Chongqing Medical University</name>
        <address>
          <city>Chongqing</city>
          <state>Chongqing</state>
          <zip>400010</zip>
          <country>China</country>
        </address>
      </facility>
    </location>
    <location_countries>
      <country>China</country>
    </location_countries>
    <reference>
      <citation>Dirrichs T, Quack V, Gatz M, Tingart M, Rath B, Betsch M, Kuhl CK, Schrading S. Shear Wave Elastography (SWE) for Monitoring of Treatment of Tendinopathies: A Double-blinded, Longitudinal Clinical Study. Acad Radiol. 2018 Mar;25(3):265-272. doi: 10.1016/j.acra.2017.09.011. Epub 2017 Nov 16.</citation>
      <PMID>29153963</PMID>
    </reference>
    <results_reference>
      <citation>DeJong H, Abbott S, Zelesco M, Spilsbury K, Ziman M, Kennedy BF, Martin L, Wood FM. Objective quantification of burn scar stiffness using shear-wave elastography: Initial evidence of validity. Burns. 2020 Dec;46(8):1787-1798. doi: 10.1016/j.burns.2020.05.009. Epub 2020 May 19.</citation>
      <PMID>32534890</PMID>
    </results_reference>
    <results_reference>
      <citation>Schwaiger H, Reinholz M, Poetschke J, Ruzicka T, Gauglitz G. Evaluating the Therapeutic Success of Keloids Treated With Cryotherapy and Intralesional Corticosteroids Using Noninvasive Objective Measures. Dermatol Surg. 2018 May;44(5):635-644. doi: 10.1097/DSS.0000000000001427.</citation>
      <PMID>29701618</PMID>
    </results_reference>
    <results_reference>
      <citation>Nast A, Gauglitz G, Lorenz K, Metelmann HR, Paasch U, Strnad V, Weidmann M, Werner RN, Bauerschmitz J. S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids) - Update 2020. J Dtsch Dermatol Ges. 2021 Feb;19(2):312-327. doi: 10.1111/ddg.14279. Epub 2020 Oct 4. No abstract available.</citation>
      <PMID>33015930</PMID>
    </results_reference>
    <results_reference>
      <citation>Yang Y, Wang L, Yan F, Xiang X, Tang Y, Zhang L, Liu J, Qiu L. Determination of Normal Skin Elasticity by Using Real-time Shear Wave Elastography. J Ultrasound Med. 2018 Nov;37(11):2507-2516. doi: 10.1002/jum.14608. Epub 2018 Mar 25.</citation>
      <PMID>29575120</PMID>
    </results_reference>
    <results_reference>
      <citation>Yang Y, Qiu L, Wang L, Xiang X, Tang Y, Li H, Yan F. Quantitative Assessment of Skin Stiffness Using Ultrasound Shear Wave Elastography in Systemic Sclerosis. Ultrasound Med Biol. 2019 Apr;45(4):902-912. doi: 10.1016/j.ultrasmedbio.2018.11.015. Epub 2019 Jan 18.</citation>
      <PMID>30665723</PMID>
    </results_reference>
    <results_reference>
      <citation>Tsai WY, Hsueh YY, Chen PY, Hung KS, Huang CC. High-Frequency Ultrasound Elastography for Assessing Elastic Properties of Skin and Scars. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 Jun;69(6):1871-1880. doi: 10.1109/TUFFC.2022.3154235. Epub 2022 May 26.</citation>
      <PMID>35201987</PMID>
    </results_reference>
    <results_reference>
      <citation>Guo R, Xiang X, Wang L, Zhu B, Cheng S, Qiu L. Quantitative Assessment of Keloids Using Ultrasound Shear Wave Elastography. Ultrasound Med Biol. 2020 May;46(5):1169-1178. doi: 10.1016/j.ultrasmedbio.2020.01.010. Epub 2020 Feb 13.</citation>
      <PMID>32063394</PMID>
    </results_reference>
    <results_reference>
      <citation>Reinholz M, Schwaiger H, Poetschke J, Epple A, Ruzicka T, Von Braunmuhl T, Gauglitz GG. Objective and subjective treatment evaluation of scars using optical coherence tomography, sonography, photography, and standardised questionnaires. Eur J Dermatol. 2016 Dec 1;26(6):599-608. doi: 10.1684/ejd.2016.2873.</citation>
      <PMID>27762215</PMID>
    </results_reference>
    <results_reference>
      <citation>Elrefaie AM, Salem RM, Faheem MH. High-resolution ultrasound for keloids and hypertrophic scar assessment. Lasers Med Sci. 2020 Mar;35(2):379-385. doi: 10.1007/s10103-019-02830-4. Epub 2019 Jun 25.</citation>
      <PMID>31240510</PMID>
    </results_reference>
    <results_reference>
      <citation>DeJong H, Abbott S, Zelesco M, Spilsbury K, Martin L, Sanderson R, Ziman M, Kennedy BF, Wood FM. A Novel, Reliable Protocol to Objectively Assess Scar Stiffness Using Shear Wave Elastography. Ultrasound Med Biol. 2020 Jul;46(7):1614-1629. doi: 10.1016/j.ultrasmedbio.2020.03.003. Epub 2020 May 5.</citation>
      <PMID>32386847</PMID>
    </results_reference>
    <results_reference>
      <citation>Xu C, Ting W, Teng Y, Long X, Wang X. Laser Speckle Contrast Imaging for the Objective Assessment of Blood Perfusion in Keloids Treated With Dual-Wavelength Laser Therapy. Dermatol Surg. 2021 Apr 1;47(4):e117-e121. doi: 10.1097/DSS.0000000000002836.</citation>
      <PMID>33795568</PMID>
    </results_reference>
    <results_reference>
      <citation>Son Y, Phillips EON, Price KM, Rosenberg LZ, Stefanovic B, Wolfe CM, Shaath TS, Om A, Cohen GF, Gunjan A. Treatment of keloids with a single dose of low-energy superficial X-ray radiation to prevent recurrence after surgical excision: An in vitro and in vivo study. J Am Acad Dermatol. 2020 Nov;83(5):1304-1314. doi: 10.1016/j.jaad.2020.06.023. Epub 2020 Jun 12.</citation>
      <PMID>32540415</PMID>
    </results_reference>
    <results_reference>
      <citation>Tang Y, Cheng S, Tang X, Guo R, Zhang L, Qiu L. Quantification of skin lesions using high-frequency ultrasound and shear wave elastography in port-wine stain patients: a clinical study. Ann Transl Med. 2019 Dec;7(24):803. doi: 10.21037/atm.2019.12.57.</citation>
      <PMID>32042819</PMID>
    </results_reference>
    <results_reference>
      <citation>Xiang X, Yan F, Yang Y, Tang Y, Wang L, Zeng J, Qiu L. Quantitative Assessment of Healthy Skin Elasticity: Reliability and Feasibility of Shear Wave Elastography. Ultrasound Med Biol. 2017 Feb;43(2):445-452. doi: 10.1016/j.ultrasmedbio.2016.10.002. Epub 2016 Dec 2.</citation>
      <PMID>27919522</PMID>
    </results_reference>
    <results_reference>
      <citation>Poetschke J, Schwaiger H, Gauglitz GG. Current and Emerging Options for Documenting Scars and Evaluating Therapeutic Progress. Dermatol Surg. 2017 Jan;43 Suppl 1:S25-S36. doi: 10.1097/DSS.0000000000000698.</citation>
      <PMID>27153039</PMID>
    </results_reference>
    <verification_date>September 2023</verification_date>
    <study_first_submitted>September 5, 2023</study_first_submitted>
    <study_first_submitted_qc>September 12, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">September 13, 2023</study_first_posted>
    <last_update_submitted>September 12, 2023</last_update_submitted>
    <last_update_submitted_qc>September 12, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">September 13, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Principal Investigator</responsible_party_type>
      <investigator_affiliation>Chongqing Medical University</investigator_affiliation>
      <investigator_full_name>Wang Zhigang</investigator_full_name>
      <investigator_title>chief physician</investigator_title>
    </responsible_party>
    <keyword>multimodal ultrasound</keyword>
    <keyword>shear wave elastography</keyword>
    <keyword>microvessel imaging</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Keloid</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT06034587
  org study id: CQMUSAZL0619
  nct id: NCT06034587
  lead sponsor: 
  is fda regulated drug: No
  is fda regulated device: No
  Skin keloids are common dermatological conditions that can lead to physical limitations,
        functional impairments, and deformities. Beyond the physiological implications, the aesthetic
        ramifications of keloids can also result in significant psychological distress, including
        anxiety and depression, causing both physical and emotional suffering to the affected
        individuals. The incidence of keloids is high, characterized by their chronicity, resistance
        to treatment, and high recurrence rate. They have become one of the most challenging
        conditions to treat across burn surgery, plastic surgery, and dermatology disciplines. The
        lack of standardized clinical treatment guidelines globally, combined with an absence of a
        well-defined standardized evaluation system, means that the effectiveness of various
        treatments is not consistently and objectively assessed, creating significant challenges in
        clinical applications. This project integrates traditional high-frequency ultrasound with
        cutting-edge technologies like real-time shear wave elastography and ultra-micro blood flow
        imaging. By using multimodal ultrasound, investigators aim to observe the therapeutic
        response of 90Sr-90Y patch treatment on skin keloids. Investigators seek to determine the
        objectivity and quantification role of multimodal ultrasound data and indicators in assessing
        keloid severity, including blood flow information and elasticity hardness. Another goal is to
        obtain quantitative data on keloid thickness, volume, stiffness, and microvascular
        distribution before and after treatment to monitor the therapy response. This would address
        the current limitations of subjective keloid scoring scales. It would also serve as an
        objective assessment standard for precise diagnosis, treatment, and follow-up of keloids in a
        clinical setting, thereby standardizing the clinical diagnosis and treatment of keloids.
  Currently, no one-size-fits-all approach exists and a universally accepted, standardized
        evaluation and treatment protocol remains elusive, making it challenging to determine which
        method is the most effective. Commonly used methods for assessing keloids, such as the
        Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS), rely
        heavily on subjective evaluations based on observer perception and patient-reported
        experiences. These methods lack objective quantitative evaluation indicators and the ability
        to visualize subcutaneous tissues, limiting their individual clinical applicability. The
        Vancouver Scar Scale (VSS) is the most established questionnaire used for the evaluation of
        pathological scarring. This scale evaluates aspects of scar vascularity, pigmentation,
        pliability, and height, with the scoring system ranging from 0 to 15, where 0 is the least
        severe and 15 is the most severe. In the study, keloids were classified into three categories
        based on the VSS score: mild (0-5), moderate (6-9), and severe (10-15).
  observational model: Cohort
  time perspective: Prospective
  measure: Change in stiffness measured by SWE
  time frame: from baseline to 6 months
  description: The difference of stiffness in good response group and poor response group
  measure: Change in microvessel signal grade measured by AP
  time frame: from baseline to 6 months
  description: The difference of microvessel signal grade in good response group and poor response group
  measure: Change in thickness measured by high frequency ultrasound
  time frame: from baseline to 6 months
  description: The difference of thickness in good response group and poor response group
  arm group label: good response group of treated keloids
  description: The Vancouver Scar Scale (VSS) is the most established questionnaire used for the evaluation of pathological scarring. This scale evaluates aspects of scar vascularity, pigmentation, pliability, and height, with the scoring system ranging from 0 to 15, where 0 is the least severe and 15 is the most severe.All the keloids in the study were classified into three categories based on the VSS score: mild (0-5), moderate (6-9), and severe (10-15).
  For treatment assessment, investigators further divided the treated participants into two groups: a good response group (showing an improvement of 5 or more points in the VSS score) and a poor response group (less than 5 points improvement in the VSS score)
  arm group label: poor response group of treated keloids
  description: The Vancouver Scar Scale (VSS) is the most established questionnaire used for the evaluation of pathological scarring. This scale evaluates aspects of scar vascularity, pigmentation, pliability, and height, with the scoring system ranging from 0 to 15, where 0 is the least severe and 15 is the most severe. All the keloids in the study keloids were classified into three categories based on the VSS score: mild (0-5), moderate (6-9), and severe(10-15).
  For treatment assessment, investigators further divided the treated participants into two groups: a good response group (showing an improvement of 5 or more points in the VSS score) and a poor response group (less than 5 points improvement in the VSS score)
  intervention type: Diagnostic Test
  intervention name: multimodal ultrasound
  description: An Aixplorer ultrasound machine (SuperSonic Imaging, Ltd, Aixen-Provence, France), equipped with AngioPLUS(AP) and shear wave elastography(SWE) functions, was used for all examinations using a 4-15MHz linear probe.AP function can detect microvessels of lesions,SWE can evaluate the stiffness of lesions and high frequency ultrasound can measure the thickness and volume of keloid.
  arm group label: good response group of treated keloids
  arm group label: poor response group of treated keloids
  intervention type: Radiation
  intervention name: radioisotope applicator therapy
  description: The radioisotope applicator therapy utilized 90Sr-90Y(0094SR814975) isotope, customized by the China Atomic Energy Research Institute. The element therapy instrument used had overall dimensions of 2.8cm x 2.8cm, with an effective treatment area of 2.0cm x 2.0cm. It delivered a radiation dose of 5.0Gy/h. Each patient received superficial radiation therapy through a single 90Sr source, administered in repeated doses. The isotope therapy instrument was customized to fit the exact size of the keloid, ensuring coverage the irradiation range extending 0.5cm beyond the keloid's edge. During treatment, the surface of the applicator was aligned with the irradiated area and directly contact the surface of the keloid tissue. The treatment was carried out low-dose irradiation method, over 5 sessions, with each session delivering a dose of 2Gy. Each irradiation lasted for 25min.
  arm group label: good response group of treated keloids
  arm group label: poor response group of treated keloids
  study pop: 
  sampling method: Probability Sample
  criteria: 
  gender: All
  minimum age: 16 Years
  maximum age: N/A
  healthy volunteers: No
  last name: Wang Zhigang
  role: Study Chair
  affiliation: Chongqing Medical University
  facility: 
  country: China
  citation: Dirrichs T, Quack V, Gatz M, Tingart M, Rath B, Betsch M, Kuhl CK, Schrading S. Shear Wave Elastography (SWE) for Monitoring of Treatment of Tendinopathies: A Double-blinded, Longitudinal Clinical Study. Acad Radiol. 2018 Mar;25(3):265-272. doi: 10.1016/j.acra.2017.09.011. Epub 2017 Nov 16.
  PMID: 29153963
  citation: DeJong H, Abbott S, Zelesco M, Spilsbury K, Ziman M, Kennedy BF, Martin L, Wood FM. Objective quantification of burn scar stiffness using shear-wave elastography: Initial evidence of validity. Burns. 2020 Dec;46(8):1787-1798. doi: 10.1016/j.burns.2020.05.009. Epub 2020 May 19.
  PMID: 32534890
  citation: Schwaiger H, Reinholz M, Poetschke J, Ruzicka T, Gauglitz G. Evaluating the Therapeutic Success of Keloids Treated With Cryotherapy and Intralesional Corticosteroids Using Noninvasive Objective Measures. Dermatol Surg. 2018 May;44(5):635-644. doi: 10.1097/DSS.0000000000001427.
  PMID: 29701618
  citation: Nast A, Gauglitz G, Lorenz K, Metelmann HR, Paasch U, Strnad V, Weidmann M, Werner RN, Bauerschmitz J. S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids) - Update 2020. J Dtsch Dermatol Ges. 2021 Feb;19(2):312-327. doi: 10.1111/ddg.14279. Epub 2020 Oct 4. No abstract available.
  PMID: 33015930
  citation: Yang Y, Wang L, Yan F, Xiang X, Tang Y, Zhang L, Liu J, Qiu L. Determination of Normal Skin Elasticity by Using Real-time Shear Wave Elastography. J Ultrasound Med. 2018 Nov;37(11):2507-2516. doi: 10.1002/jum.14608. Epub 2018 Mar 25.
  PMID: 29575120
  citation: Yang Y, Qiu L, Wang L, Xiang X, Tang Y, Li H, Yan F. Quantitative Assessment of Skin Stiffness Using Ultrasound Shear Wave Elastography in Systemic Sclerosis. Ultrasound Med Biol. 2019 Apr;45(4):902-912. doi: 10.1016/j.ultrasmedbio.2018.11.015. Epub 2019 Jan 18.
  PMID: 30665723
  citation: Tsai WY, Hsueh YY, Chen PY, Hung KS, Huang CC. High-Frequency Ultrasound Elastography for Assessing Elastic Properties of Skin and Scars. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 Jun;69(6):1871-1880. doi: 10.1109/TUFFC.2022.3154235. Epub 2022 May 26.
  PMID: 35201987
  citation: Guo R, Xiang X, Wang L, Zhu B, Cheng S, Qiu L. Quantitative Assessment of Keloids Using Ultrasound Shear Wave Elastography. Ultrasound Med Biol. 2020 May;46(5):1169-1178. doi: 10.1016/j.ultrasmedbio.2020.01.010. Epub 2020 Feb 13.
  PMID: 32063394
  citation: Reinholz M, Schwaiger H, Poetschke J, Epple A, Ruzicka T, Von Braunmuhl T, Gauglitz GG. Objective and subjective treatment evaluation of scars using optical coherence tomography, sonography, photography, and standardised questionnaires. Eur J Dermatol. 2016 Dec 1;26(6):599-608. doi: 10.1684/ejd.2016.2873.
  PMID: 27762215
  citation: Elrefaie AM, Salem RM, Faheem MH. High-resolution ultrasound for keloids and hypertrophic scar assessment. Lasers Med Sci. 2020 Mar;35(2):379-385. doi: 10.1007/s10103-019-02830-4. Epub 2019 Jun 25.
  PMID: 31240510
  citation: DeJong H, Abbott S, Zelesco M, Spilsbury K, Martin L, Sanderson R, Ziman M, Kennedy BF, Wood FM. A Novel, Reliable Protocol to Objectively Assess Scar Stiffness Using Shear Wave Elastography. Ultrasound Med Biol. 2020 Jul;46(7):1614-1629. doi: 10.1016/j.ultrasmedbio.2020.03.003. Epub 2020 May 5.
  PMID: 32386847
  citation: Xu C, Ting W, Teng Y, Long X, Wang X. Laser Speckle Contrast Imaging for the Objective Assessment of Blood Perfusion in Keloids Treated With Dual-Wavelength Laser Therapy. Dermatol Surg. 2021 Apr 1;47(4):e117-e121. doi: 10.1097/DSS.0000000000002836.
  PMID: 33795568
  citation: Son Y, Phillips EON, Price KM, Rosenberg LZ, Stefanovic B, Wolfe CM, Shaath TS, Om A, Cohen GF, Gunjan A. Treatment of keloids with a single dose of low-energy superficial X-ray radiation to prevent recurrence after surgical excision: An in vitro and in vivo study. J Am Acad Dermatol. 2020 Nov;83(5):1304-1314. doi: 10.1016/j.jaad.2020.06.023. Epub 2020 Jun 12.
  PMID: 32540415
  citation: Tang Y, Cheng S, Tang X, Guo R, Zhang L, Qiu L. Quantification of skin lesions using high-frequency ultrasound and shear wave elastography in port-wine stain patients: a clinical study. Ann Transl Med. 2019 Dec;7(24):803. doi: 10.21037/atm.2019.12.57.
  PMID: 32042819
  citation: Xiang X, Yan F, Yang Y, Tang Y, Wang L, Zeng J, Qiu L. Quantitative Assessment of Healthy Skin Elasticity: Reliability and Feasibility of Shear Wave Elastography. Ultrasound Med Biol. 2017 Feb;43(2):445-452. doi: 10.1016/j.ultrasmedbio.2016.10.002. Epub 2016 Dec 2.
  PMID: 27919522
  citation: Poetschke J, Schwaiger H, Gauglitz GG. Current and Emerging Options for Documenting Scars and Evaluating Therapeutic Progress. Dermatol Surg. 2017 Jan;43 Suppl 1:S25-S36. doi: 10.1097/DSS.0000000000000698.
  PMID: 27153039
  responsible party type: Principal Investigator
  investigator affiliation: Chongqing Medical University
  investigator full name: Wang Zhigang
  investigator title: chief physician
  mesh term: Keloid
  sharing ipd: No