xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT05994391</url>
    </required_header>
    <id_info>
      <org_study_id>IRB-22-78</org_study_id>
      <nct_id>NCT05994391</nct_id>
    </id_info>
    <brief_title>A Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of LasoperinTM on Cognitive Function in Healthy Adults</brief_title>
    <acronym>COG</acronym>
    <official_title>A Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of LasoperinTM on Cognitive Function in Healthy Adults</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Lindenwood University</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Lindenwood University</source>
    <oversight_info>
      <has_dmc>No</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        The potential impact of various dietary ingredients to improve cognitive function, mood,&#xD;
        well-being, and overall levels of affects are largely undetermined. The purpose of this study&#xD;
        is to determine the effects of a combination of two dietary supplements, Scutellaria&#xD;
        baicalensis and Acacia catech, on cognitive function, well-being, mood, cognitive&#xD;
        interferences, and inflammation.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        The proposed study design will be a randomized, double-blind, placebo-controlled, parallel&#xD;
        design to evaluate the effect of the supplement on cognitive function, well-being, mood,&#xD;
        cognitive interferences, and inflammation. Participants will complete a series of&#xD;
        psychological questionnaires, cognitive assessments, and venous blood draws.&#xD;
  &#xD;
        Screening Visit (Visit 1) Upon arrival to the lab, participants will receive an informed&#xD;
        consent document and will be required to give full consent before proceeding. Upon providing&#xD;
        consent, participants will provide personal and emergency contact information before&#xD;
        completing a health history form, exercise history form, and a physical activity&#xD;
        questionnaire. Prior to this visit and each subsequent visit, participants will be required&#xD;
        to observe an overnight fast (8-10 hours) of food or drink with calories including any foods&#xD;
        or beverages that contain alcohol, caffeine, and nicotine. Participants will be instructed to&#xD;
        be well-rested and to avoid exercise for 24 hours prior to each visit. Water intake will be&#xD;
        encouraged during this time for appropriate hydration status. Participants will then have&#xD;
        their height, body mass, resting heart rate, blood pressure, and urine specific gravity&#xD;
        measured prior to completing their body composition assessment (only study visit 1) using a&#xD;
        bioelectrical impedance analyzer (BIA). This study visit and all subsequent study visits will&#xD;
        be scheduled between 0600 - 1000 hours. This study visit is estimated to take about 45&#xD;
        minutes to complete.&#xD;
  &#xD;
        Visit 2-4 There is no required minimum time between Visit 1 and Visit 2. Visit 3 will occur&#xD;
        15 ± 3 days after Visit 2, 2 and Visit 4 will occur 28 ± 3 days after Visit 3. Participants&#xD;
        will be required to follow identical pre-testing guidelines consisting of an overnight fast&#xD;
        (8-10 hours) of food or drink with calories including any foods or beverages that contain&#xD;
        alcohol, caffeine, and nicotine. Participants will be instructed to be well-rested and to&#xD;
        avoid exercise for 24 hours prior to each visit. Water intake will be encouraged during this&#xD;
        time for appropriate hydration status. Body mass, resting heart rate, and resting blood&#xD;
        pressure will be measured. Female participants will take a urine pregnancy test to ensure&#xD;
        they are not pregnant. Using standard phlebotomy approaches, approximately 21 mL of venous&#xD;
        blood will be collected from a forearm vein. Participants will then complete the NIH Toolbox&#xD;
        Cognitive Function Battery, NIH Toolbox Emotion Function Test, RAND SF-36 to assess&#xD;
        well-being/mood, Stroop Color and Word test, Trail Making Test A and B, Finger tapping test,&#xD;
        and the NIH Toolbox General Life Satisfaction score. After baseline testing, participants&#xD;
        will be randomly assigned in a double-blind fashion to ingest on a daily basis for 6 weeks&#xD;
        either a placebo or a dietary supplement. They will consume their supplement at the end of&#xD;
        visits 2 and 3. Supplement compliance will be assessed through daily logging by the&#xD;
        participant and checked by research team members calculating remaining amount of supplement&#xD;
        during study visits.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Completed</overall_status>
    <start_date type="Actual">June 3, 2022</start_date>
    <completion_date type="Actual">October 18, 2022</completion_date>
    <primary_completion_date type="Actual">October 18, 2022</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>Randomized</allocation>
      <intervention_model>Parallel Assignment</intervention_model>
      <intervention_model_description>Randomized, double-blind, placebo-controlled, parallel design</intervention_model_description>
      <primary_purpose>Other</primary_purpose>
      <masking>Double (Participant, Investigator)</masking>
      <masking_description>All supplements will be in sealed, blinded packaging with identical information on each package. Supplements will be blinded by a third party who is not a member of the research team.</masking_description>
    </study_design_info>
    <primary_outcome>
      <measure>NIH Toolbox Cognitive Testing - Flanker Inhibitory Control</measure>
      <time_frame>30 days</time_frame>
      <description>The first test is the Flanker inhibitory control and attention test which tests the participant's attention and executive function. This test requires the participant to maintain attention on a central stimulus while inhibiting the attention to distracting stimuli. The participant will be asked to match the direction of the central arrow while disregarding the surrounding distraction arrows. This test will measure both the reaction time and the accuracy of the participant's decisions.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>NIH Toolbox Cognitive Testing - dimensional change card sort test</measure>
      <time_frame>30 days</time_frame>
      <description>The second test is the dimensional change card sort test which measures a component of executive function known as set-shifting. Set-shifting is the ability to change responses based on a set of rules. In this test the participant will match images based either on color or shape. This test will measure both the reaction time and the accuracy of the participant's decisions.&#xD;
  The third test is the pattern comparison processing speed test which measures processing speed. The participants will be shown two images and will be asked to evaluate if they are the same image. This test will measure the number of items that are answered correctly in 85 seconds.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>NIH Toolbox Cognitive Testing - Pattern Comparison Processing Speed Test</measure>
      <time_frame>30 days</time_frame>
      <description>The third test is the pattern comparison processing speed test which measures processing speed. The participants will be shown two images and will be asked to evaluate if they are the same image. This test will measure the number of items that are answered correctly in 85 seconds.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>NIH Toolbox General Life Satisfaction Questionnaire</measure>
      <time_frame>30 days</time_frame>
      <description>The NIH Toolbox was created to standardize the measure of positive and negative aspects of emotions.6 The effect of the study product on the participants' life will be measured using the general life satisfaction questionnaire from the NIH Toolbox. This will measure the participant's satisfaction with themselves and other areas of their life.6 This questionnaire will be completed on Visits 2, 3, and 4.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>RAND SF-36 Questionnaire</measure>
      <time_frame>30 days</time_frame>
      <description>The RAND SF-36 is a short questionnaire that measures health-related quality of life.7 The questionnaire measures eight concepts of health using 36 questions.7 The eight concepts measured are: physical functioning, pain, role limitations due to physical health, role limitations due to emotional problems, emotional well-being, social functioning, energy/fatigue, and general health. This questionnaire will be completed on Visits 2, 3, and 4.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Stroop Color Test</measure>
      <time_frame>30 days</time_frame>
      <description>The Stroop color test measures the ability to stop cognitive interference of processing an initial stimulus from interfering with the simultaneous processing of a second stimulus.8 The participant will be tested using an app (Brain Test - Stroop Effect, Attila Hegedus, v1.5.0) on a tablet (iPad, Apple, Inc.). In a seated positions with no other distractions, the participant will be shown two color words, red or green. The words could be written in congruent conditions (e.g., the word red written in red ink) or incongruent conditions (e.g., the word red written in green ink). The participant must select the correct matching ink color for the presented word. The participant will have 60 seconds to match as many conditions correctly as possible. Correct responses add one point and incorrect responses will subtract one point from the total score. The test will be repeated three times and the best score will be recorded. This test will be completed on Visits 2, 3, and 4.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Trail Making Test Parts A &amp; B</measure>
      <time_frame>30 days</time_frame>
      <description>The trail making test provides information of cognitive processes such as attention, flexibility, and visual search and scanning.9 The participant will be tested using an app (INPL Trail Making Test, Motus Design Group) on a tablet (iPad, Apple, Inc.) in a comfortable seated position. When conducting the test there are two parts, part A and B. Part A requires the participant to tap circled numbers in sequence as quickly as possible (i.e., 1-2-3, etc.). Part B requires the participant to tap both circled numbers and letters in alternating numeric and alphabetical order as quickly as possible (i.e., 1-A-2-B, etc.). The time that it takes to complete each part of the test will be measured. This test will be completed on Visits 2, 3, and 4.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Finger Tapping Test</measure>
      <time_frame>30 days</time_frame>
      <description>The finger tapping test is commonly used to evaluate the motor function and muscle control of the upper extremities.10 The participant will be tested using an app (Finger Tapping Test, SYBU Data, v3.5) on a tablet (iPad, Apple, Inc.). They will be instructed to sit comfortably in a chair with their palm flat on a desk or table. In this position, the participant will begin the test by tapping on the screen with the index finger of their dominant hand as quickly and consistently as they can in 10 second intervals. The participant will get one practice trial before completing three consecutive trials. Approximately 30 seconds of rest will be given in between each practice and testing trial. After the dominant hand is tested, the participant will repeat the test using the non-dominant hand. Upon completion of the third trial, the average number of taps for both the dominant and non-dominant hand will be calculated and recorded. This test will be completed on Visits 2, 3, and 4</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Blood Collection - C-Reactive Protein (CRP)</measure>
      <time_frame>30 days</time_frame>
      <description>CRP is a non-specific indicator for inflammation. Studies have shown that there is an association between elevated levels of CRP and an increased risk of dementia and cerebrovascular disease in clinically compromised populations.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Blood Collection - Cortisol</measure>
      <time_frame>30 days</time_frame>
      <description>Both dementia and mild cognitive impairment have been associated with elevated levels of cortisol. Chronic elevated levels of cortisol cause functional atrophy to areas of the brain that are associated with cognitive function.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Blood Collection - Brain Derived Neurotrophic Factor (BDNF)</measure>
      <time_frame>30 days</time_frame>
      <description>BDNF is essential in the function of neural processes, and changing levels may contribute neurodegenerative diseases. In conditions of low BDNF there is growing evidence to show that the brain is more susceptible to oxidative stress.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Blood Collection - Uric Acid</measure>
      <time_frame>30 days</time_frame>
      <description>Uric acid is a natural antioxidant and contributes greatly to the antioxidant capabilities of blood plasma. Increased oxidative stress has been associated with increased risk of cognitive impairment and dementia.</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Resting Heart Rate</measure>
      <time_frame>30 days</time_frame>
      <description>5 minute resting heart rate taken</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Resting Blood Pressure</measure>
      <time_frame>30 days</time_frame>
      <description>5 minute resting blood pressure taken</description>
    </secondary_outcome>
    <number_of_arms>2</number_of_arms>
    <enrollment type="Actual">100</enrollment>
    <condition>Cognitive Impairment</condition>
    <condition>Cognitive Decline</condition>
    <condition>Cognition Disorders in Old Age</condition>
    <condition>Well-Being, Psychological</condition>
    <condition>Inflammation</condition>
    <condition>Cognitive Fun</condition>
    <arm_group>
      <arm_group_label>LasoperinTM</arm_group_label>
      <arm_group_type>Experimental</arm_group_type>
      <description>Active ingredients:&#xD;
  Scutellaria baicalensis extract, 240 mg per capsule. Acacia catechu extract, 51 mg per capsule. With no less than 180 mg of baicalin, and no less than 30 mg of catechins from the above-mentioned extracts per capsule.&#xD;
  Inactive ingredients:&#xD;
  Maltodextrin&#xD;
  2 capsules per day&#xD;
  Take twice per day with food and water, once in the morning and once in the evening.&#xD;
  If a dose is missed the participant can consume it as soon as they remember within the day. This means that the participant may consume 2 capsules at once. If both capsules are missed for the day the participant should not consume 4 capsules the next day and should return to the normal dosage of one capsule in the morning and evening</description>
    </arm_group>
    <arm_group>
      <arm_group_label>Placebo</arm_group_label>
      <arm_group_type>Placebo Comparator</arm_group_type>
      <description>Active ingredients:&#xD;
  N/A&#xD;
  Inactive ingredients:&#xD;
  Microcrystalline cellulose&#xD;
  2 capsules per day&#xD;
  Take twice per day with food and water, once in the morning and once in the evening.&#xD;
  If a dose is missed the participant can consume it as soon as they remember within the day. This means that the participant may consume 2 capsules at once. If both capsules are missed for the day the participant should not consume 4 capsules the next day and should return to the normal dosage of one capsule in the morning and evening</description>
    </arm_group>
    <intervention>
      <intervention_type>Dietary Supplement</intervention_type>
      <intervention_name>LasoperinTM</intervention_name>
      <description>Active ingredients:&#xD;
  Scutellaria baicalensis extract, 240 mg per capsule. Acacia catechu extract, 51 mg per capsule. With no less than 180 mg of baicalin, and no less than 30 mg of catechins from the above-mentioned extracts per capsule.&#xD;
  Inactive ingredients:&#xD;
  Maltodextrin</description>
      <arm_group_label>LasoperinTM</arm_group_label>
    </intervention>
    <intervention>
      <intervention_type>Dietary Supplement</intervention_type>
      <intervention_name>Placeo</intervention_name>
      <description>Active ingredients:&#xD;
  N/A&#xD;
  Inactive ingredients:&#xD;
  Microcrystalline cellulose</description>
      <arm_group_label>Placebo</arm_group_label>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            1. Healthy adult participants who are 30 to 60 years of age (inclusive).&#xD;
  &#xD;
            2. In good general health (no active or uncontrolled diseases or conditions).&#xD;
  &#xD;
            3. Have a body mass index (BMI) between 18.0 to 34.9 kg/m2 (inclusive).&#xD;
  &#xD;
            4. Have normal or acceptable to the investigator vital signs (blood pressure and heart&#xD;
               rate) at screening and/or baseline.&#xD;
  &#xD;
            5. Individuals with childbearing potential must agree to practice an acceptable form of&#xD;
               birth control for a certain timeframe prior to the first dose of study product and&#xD;
               throughout the study, including:&#xD;
  &#xD;
                 1. use for at least 3 months prior to the first dose of study product: hormonal&#xD;
                    contraceptives including oral contraceptives, hormone birth control patch (e.g.,&#xD;
                    Ortho Evra), vaginal contraceptive ring (e.g., NuvaRing), injectable&#xD;
                    contraceptives (e.g., Depo-Provera, Lunelle), or hormone implant (e.g., Norplant&#xD;
                    System); or&#xD;
  &#xD;
                 2. use for at least 1 month prior to the first dose of study product: double-barrier&#xD;
                    method, intrauterine devices, or complete abstinence from sexual intercourse that&#xD;
                    can result in pregnancy; or&#xD;
  &#xD;
                 3. vasectomy of partner at least 6 months prior to the first dose of study product.&#xD;
  &#xD;
               Individuals with the potential to impregnate others must agree to use condoms or other&#xD;
               acceptable methods to prevent pregnancy throughout the study. Complete abstinence from&#xD;
               sexual intercourse that can result in pregnancy is also acceptable.&#xD;
  &#xD;
            6. Agree to refrain from treatments listed in Section 6.4 in the defined timeframe.&#xD;
  &#xD;
            7. Willing to refrain from changing their diet or lifestyle significantly for the&#xD;
               duration of the study.&#xD;
  &#xD;
            8. Willing and able to agree to the requirements and restrictions of this study, be&#xD;
               willing to give voluntary consent, be able to understand and read the questionnaires,&#xD;
               and carry out all study-related procedures.&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  1. Participants who are lactating, pregnant or planning to become pregnant during the&#xD;
               study.&#xD;
  &#xD;
               2. Have a known sensitivity, intolerability, or allergy to any of the study products&#xD;
               or their excipients, or any of the rescue medications.&#xD;
  &#xD;
               3. Received a vaccine for COVID-19 in the 2 weeks prior to screening or during the&#xD;
               study period, current COVID-19 infections, or currently have the post COVID-19&#xD;
               condition as defined by World Health Organization (WHO) (i.e., individuals with a&#xD;
               history of probable or confirmed SARS-CoV-2 infection, usually 3 months from the onset&#xD;
               of COVID-19 with symptoms that last for at least 2 months and cannot be explained by&#xD;
               an alternative diagnosis).&#xD;
  &#xD;
               4. Participants with diagnosed type I or type II diabetes. 5. Having a history of&#xD;
               heart disease, uncontrolled high blood pressure (≥140 mmHg systolic or ≥90 mmHg&#xD;
               diastolic), renal or hepatic impairment/disease, major affective disorders, hepatic or&#xD;
               renal dysfunction, unstable thyroid disease, immune disorders and/or immunocompromised&#xD;
               (e.g. HIV/AIDS), cognitive impairment, neurological condition, or neurological&#xD;
               disease, psychiatric disorder that required hospitalization in the past year, cancer&#xD;
               (except localized skin cancer without metastases or in situ cervical cancer) within 5&#xD;
               years prior to the screening visit, or any clinically significant disease or disorder&#xD;
               which, in the opinion of the investigator, may either put the potential participant at&#xD;
               risk because of participation in the study, or influences the results or the potential&#xD;
               participant's ability to participate in the study.&#xD;
  &#xD;
               6. Major surgery in 3 months prior to screening or planned major surgery during the&#xD;
               course of the study.&#xD;
  &#xD;
               7. Participant has a pacemaker or implantable cardiac defibrillator. 8. Participant&#xD;
               has an abnormality or obstruction of the gastrointestinal tract precluding swallowing&#xD;
               (e.g. dysphagia) and digestions (e.g. known intestinal malabsorption, celiac disease,&#xD;
               inflammatory bowel disease, chronic pancreatitis, steatorrhea).&#xD;
  &#xD;
               9. Participant has a history of alcohol or substance abuse in the 12 months prior to&#xD;
               screening.&#xD;
  &#xD;
               10. Receipt or use of test product(s) in another research study within 28 days prior&#xD;
               to baseline or longer if the previous test product is deemed by the investigator to&#xD;
               have lasting effects that might influence the eligibility criteria or outcomes of&#xD;
               current study.&#xD;
  &#xD;
               11. Any other active or unstable medical conditions or use of medications/supplements/&#xD;
               therapies that, in the opinion of the investigator, may adversely affect the&#xD;
               participant's ability to complete the study or its measures or pose a significant risk&#xD;
               to the participant.&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>30 Years</minimum_age>
      <maximum_age>60 Years</maximum_age>
      <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
    </eligibility>
    <location>
      <facility>
        <name>Exercise and Performance Nutrition Laboratory</name>
        <address>
          <city>Saint Charles</city>
          <state>Missouri</state>
          <zip>63301</zip>
          <country>United States</country>
        </address>
      </facility>
    </location>
    <location_countries>
      <country>United States</country>
    </location_countries>
    <verification_date>August 2023</verification_date>
    <study_first_submitted>August 8, 2023</study_first_submitted>
    <study_first_submitted_qc>August 8, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 16, 2023</study_first_posted>
    <last_update_submitted>August 8, 2023</last_update_submitted>
    <last_update_submitted_qc>August 8, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">August 16, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Sponsor</responsible_party_type>
    </responsible_party>
    <keyword>cognitive function</keyword>
    <keyword>inflammation</keyword>
    <keyword>well being</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Inflammation</mesh_term>
      <mesh_term>Cognitive Dysfunction</mesh_term>
      <mesh_term>Cognition Disorders</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT05994391
  org study id: IRB-22-78
  nct id: NCT05994391
  lead sponsor: 
  has dmc: No
  is fda regulated drug: No
  is fda regulated device: No
  The potential impact of various dietary ingredients to improve cognitive function, mood,
        well-being, and overall levels of affects are largely undetermined. The purpose of this study
        is to determine the effects of a combination of two dietary supplements, Scutellaria
        baicalensis and Acacia catech, on cognitive function, well-being, mood, cognitive
        interferences, and inflammation.
  The proposed study design will be a randomized, double-blind, placebo-controlled, parallel
        design to evaluate the effect of the supplement on cognitive function, well-being, mood,
        cognitive interferences, and inflammation. Participants will complete a series of
        psychological questionnaires, cognitive assessments, and venous blood draws.
  
        Screening Visit (Visit 1) Upon arrival to the lab, participants will receive an informed
        consent document and will be required to give full consent before proceeding. Upon providing
        consent, participants will provide personal and emergency contact information before
        completing a health history form, exercise history form, and a physical activity
        questionnaire. Prior to this visit and each subsequent visit, participants will be required
        to observe an overnight fast (8-10 hours) of food or drink with calories including any foods
        or beverages that contain alcohol, caffeine, and nicotine. Participants will be instructed to
        be well-rested and to avoid exercise for 24 hours prior to each visit. Water intake will be
        encouraged during this time for appropriate hydration status. Participants will then have
        their height, body mass, resting heart rate, blood pressure, and urine specific gravity
        measured prior to completing their body composition assessment (only study visit 1) using a
        bioelectrical impedance analyzer (BIA). This study visit and all subsequent study visits will
        be scheduled between 0600 - 1000 hours. This study visit is estimated to take about 45
        minutes to complete.
  
        Visit 2-4 There is no required minimum time between Visit 1 and Visit 2. Visit 3 will occur
        15 ± 3 days after Visit 2, 2 and Visit 4 will occur 28 ± 3 days after Visit 3. Participants
        will be required to follow identical pre-testing guidelines consisting of an overnight fast
        (8-10 hours) of food or drink with calories including any foods or beverages that contain
        alcohol, caffeine, and nicotine. Participants will be instructed to be well-rested and to
        avoid exercise for 24 hours prior to each visit. Water intake will be encouraged during this
        time for appropriate hydration status. Body mass, resting heart rate, and resting blood
        pressure will be measured. Female participants will take a urine pregnancy test to ensure
        they are not pregnant. Using standard phlebotomy approaches, approximately 21 mL of venous
        blood will be collected from a forearm vein. Participants will then complete the NIH Toolbox
        Cognitive Function Battery, NIH Toolbox Emotion Function Test, RAND SF-36 to assess
        well-being/mood, Stroop Color and Word test, Trail Making Test A and B, Finger tapping test,
        and the NIH Toolbox General Life Satisfaction score. After baseline testing, participants
        will be randomly assigned in a double-blind fashion to ingest on a daily basis for 6 weeks
        either a placebo or a dietary supplement. They will consume their supplement at the end of
        visits 2 and 3. Supplement compliance will be assessed through daily logging by the
        participant and checked by research team members calculating remaining amount of supplement
        during study visits.
  allocation: Randomized
  intervention model: Parallel Assignment
  intervention model description: Randomized, double-blind, placebo-controlled, parallel design
  primary purpose: Other
  masking: Double (Participant, Investigator)
  masking description: All supplements will be in sealed, blinded packaging with identical information on each package. Supplements will be blinded by a third party who is not a member of the research team.
  measure: NIH Toolbox Cognitive Testing - Flanker Inhibitory Control
  time frame: 30 days
  description: The first test is the Flanker inhibitory control and attention test which tests the participant's attention and executive function. This test requires the participant to maintain attention on a central stimulus while inhibiting the attention to distracting stimuli. The participant will be asked to match the direction of the central arrow while disregarding the surrounding distraction arrows. This test will measure both the reaction time and the accuracy of the participant's decisions.
  measure: NIH Toolbox Cognitive Testing - dimensional change card sort test
  time frame: 30 days
  description: The second test is the dimensional change card sort test which measures a component of executive function known as set-shifting. Set-shifting is the ability to change responses based on a set of rules. In this test the participant will match images based either on color or shape. This test will measure both the reaction time and the accuracy of the participant's decisions.
  The third test is the pattern comparison processing speed test which measures processing speed. The participants will be shown two images and will be asked to evaluate if they are the same image. This test will measure the number of items that are answered correctly in 85 seconds.
  measure: NIH Toolbox Cognitive Testing - Pattern Comparison Processing Speed Test
  time frame: 30 days
  description: The third test is the pattern comparison processing speed test which measures processing speed. The participants will be shown two images and will be asked to evaluate if they are the same image. This test will measure the number of items that are answered correctly in 85 seconds.
  measure: NIH Toolbox General Life Satisfaction Questionnaire
  time frame: 30 days
  description: The NIH Toolbox was created to standardize the measure of positive and negative aspects of emotions.6 The effect of the study product on the participants' life will be measured using the general life satisfaction questionnaire from the NIH Toolbox. This will measure the participant's satisfaction with themselves and other areas of their life.6 This questionnaire will be completed on Visits 2, 3, and 4.
  measure: RAND SF-36 Questionnaire
  time frame: 30 days
  description: The RAND SF-36 is a short questionnaire that measures health-related quality of life.7 The questionnaire measures eight concepts of health using 36 questions.7 The eight concepts measured are: physical functioning, pain, role limitations due to physical health, role limitations due to emotional problems, emotional well-being, social functioning, energy/fatigue, and general health. This questionnaire will be completed on Visits 2, 3, and 4.
  measure: Stroop Color Test
  time frame: 30 days
  description: The Stroop color test measures the ability to stop cognitive interference of processing an initial stimulus from interfering with the simultaneous processing of a second stimulus.8 The participant will be tested using an app (Brain Test - Stroop Effect, Attila Hegedus, v1.5.0) on a tablet (iPad, Apple, Inc.). In a seated positions with no other distractions, the participant will be shown two color words, red or green. The words could be written in congruent conditions (e.g., the word red written in red ink) or incongruent conditions (e.g., the word red written in green ink). The participant must select the correct matching ink color for the presented word. The participant will have 60 seconds to match as many conditions correctly as possible. Correct responses add one point and incorrect responses will subtract one point from the total score. The test will be repeated three times and the best score will be recorded. This test will be completed on Visits 2, 3, and 4.
  measure: Trail Making Test Parts A & B
  time frame: 30 days
  description: The trail making test provides information of cognitive processes such as attention, flexibility, and visual search and scanning.9 The participant will be tested using an app (INPL Trail Making Test, Motus Design Group) on a tablet (iPad, Apple, Inc.) in a comfortable seated position. When conducting the test there are two parts, part A and B. Part A requires the participant to tap circled numbers in sequence as quickly as possible (i.e., 1-2-3, etc.). Part B requires the participant to tap both circled numbers and letters in alternating numeric and alphabetical order as quickly as possible (i.e., 1-A-2-B, etc.). The time that it takes to complete each part of the test will be measured. This test will be completed on Visits 2, 3, and 4.
  measure: Finger Tapping Test
  time frame: 30 days
  description: The finger tapping test is commonly used to evaluate the motor function and muscle control of the upper extremities.10 The participant will be tested using an app (Finger Tapping Test, SYBU Data, v3.5) on a tablet (iPad, Apple, Inc.). They will be instructed to sit comfortably in a chair with their palm flat on a desk or table. In this position, the participant will begin the test by tapping on the screen with the index finger of their dominant hand as quickly and consistently as they can in 10 second intervals. The participant will get one practice trial before completing three consecutive trials. Approximately 30 seconds of rest will be given in between each practice and testing trial. After the dominant hand is tested, the participant will repeat the test using the non-dominant hand. Upon completion of the third trial, the average number of taps for both the dominant and non-dominant hand will be calculated and recorded. This test will be completed on Visits 2, 3, and 4
  measure: Blood Collection - C-Reactive Protein (CRP)
  time frame: 30 days
  description: CRP is a non-specific indicator for inflammation. Studies have shown that there is an association between elevated levels of CRP and an increased risk of dementia and cerebrovascular disease in clinically compromised populations.
  measure: Blood Collection - Cortisol
  time frame: 30 days
  description: Both dementia and mild cognitive impairment have been associated with elevated levels of cortisol. Chronic elevated levels of cortisol cause functional atrophy to areas of the brain that are associated with cognitive function.
  measure: Blood Collection - Brain Derived Neurotrophic Factor (BDNF)
  time frame: 30 days
  description: BDNF is essential in the function of neural processes, and changing levels may contribute neurodegenerative diseases. In conditions of low BDNF there is growing evidence to show that the brain is more susceptible to oxidative stress.
  measure: Blood Collection - Uric Acid
  time frame: 30 days
  description: Uric acid is a natural antioxidant and contributes greatly to the antioxidant capabilities of blood plasma. Increased oxidative stress has been associated with increased risk of cognitive impairment and dementia.
  measure: Resting Heart Rate
  time frame: 30 days
  description: 5 minute resting heart rate taken
  measure: Resting Blood Pressure
  time frame: 30 days
  description: 5 minute resting blood pressure taken
  arm group label: LasoperinTM
  arm group type: Experimental
  description: Active ingredients:
  Scutellaria baicalensis extract, 240 mg per capsule. Acacia catechu extract, 51 mg per capsule. With no less than 180 mg of baicalin, and no less than 30 mg of catechins from the above-mentioned extracts per capsule.
  Inactive ingredients:
  Maltodextrin
  2 capsules per day
  Take twice per day with food and water, once in the morning and once in the evening.
  If a dose is missed the participant can consume it as soon as they remember within the day. This means that the participant may consume 2 capsules at once. If both capsules are missed for the day the participant should not consume 4 capsules the next day and should return to the normal dosage of one capsule in the morning and evening
  arm group label: Placebo
  arm group type: Placebo Comparator
  description: Active ingredients:
  N/A
  Inactive ingredients:
  Microcrystalline cellulose
  2 capsules per day
  Take twice per day with food and water, once in the morning and once in the evening.
  If a dose is missed the participant can consume it as soon as they remember within the day. This means that the participant may consume 2 capsules at once. If both capsules are missed for the day the participant should not consume 4 capsules the next day and should return to the normal dosage of one capsule in the morning and evening
  intervention type: Dietary Supplement
  intervention name: LasoperinTM
  description: Active ingredients:
  Scutellaria baicalensis extract, 240 mg per capsule. Acacia catechu extract, 51 mg per capsule. With no less than 180 mg of baicalin, and no less than 30 mg of catechins from the above-mentioned extracts per capsule.
  Inactive ingredients:
  Maltodextrin
  arm group label: LasoperinTM
  intervention type: Dietary Supplement
  intervention name: Placeo
  description: Active ingredients:
  N/A
  Inactive ingredients:
  Microcrystalline cellulose
  arm group label: Placebo
  criteria: 
  gender: All
  minimum age: 30 Years
  maximum age: 60 Years
  healthy volunteers: Accepts Healthy Volunteers
  facility: 
  country: United States
  responsible party type: Sponsor
  mesh term: Inflammation
  mesh term: Cognitive Dysfunction
  mesh term: Cognition Disorders
  sharing ipd: No