xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT05999071</url>
    </required_header>
    <id_info>
      <org_study_id>21/6/2022/2023</org_study_id>
      <nct_id>NCT05999071</nct_id>
    </id_info>
    <brief_title>Coriandrum Sativum Seeds Improve Memory, Alleviate Anxiety and Depression, and Enhance Sleep Quality in University Students: A Randomized Controlled Trial</brief_title>
    <official_title>Coriandrum Sativum Seeds Improve Memory, Alleviate Anxiety and Depression, and Enhance Sleep Quality in University Students: A Randomized Controlled Trial</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>The Hashemite University</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>The Hashemite University</source>
    <oversight_info>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        C. sativum could potentially serve as a memory enhancer for university students. It is&#xD;
        considered a preferable option to stimulant drugs due to its safety profile. Additionally, C.&#xD;
        sativum may have positive effects on anxiety, depression, and sleep quality. However, it is&#xD;
        important to note that the current body of research on the effects of oral C. sativum on the&#xD;
        brain and nervous system is limited, and further studies are necessary to fully understand&#xD;
        its potential benefits. Thus, this study aims to assess the impact of oral C. sativum on&#xD;
        memory performance, anxiety, depression, and sleep quality in university students.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        Coriander, scientifically known as Coriandrum sativum L (C. sativum), is an ancient herb that&#xD;
        belongs to the Apiaceae family. It has a rich history of more than 3,000 years of use in both&#xD;
        culinary and medicinal practices. While originally native to Mediterranean regions, coriander&#xD;
        is now cultivated in various countries worldwide. In traditional medicine, all parts of the&#xD;
        coriander plant have been consumed and utilized to address gastrointestinal ailments like&#xD;
        anorexia, dyspepsia, flatulence, diarrhea, pain, and vomiting. In Jordanian traditional&#xD;
        medicine, C. sativum has been valued for its anticonvulsant, antidepressant, sedative, and&#xD;
        anxiolytic properties. Studies have reported diverse health benefits associated with C.&#xD;
        sativum seeds and leaves, including antioxidant, diuretic, cholesterol-lowering, anxiolytic,&#xD;
        sedative-hypnotic, and anticonvulsant activities. Notably, the main component of C. sativum,&#xD;
        linalool, along with γ-terpinene and α-pinene, exhibit various neuropharmacological effects,&#xD;
        such as anti-anxiety, sedative, anticonvulsant, and anti-Alzheimer's disease properties.&#xD;
        Additionally, C. sativum seeds are recognized as a valuable source of vitamins, lipids, and&#xD;
        minerals like potassium, calcium, phosphorus, magnesium, sodium, and zinc.&#xD;
  &#xD;
        Several studies have indicated the positive effects of C. sativum on memory, anxiety, and&#xD;
        depression. In a specific study, the aqueous extract derived from the seeds of C. sativum&#xD;
        demonstrated significant reductions in monoamine oxidase-B (MAO-B) activity over time,&#xD;
        suggesting its primary role in exerting antidepressant-like effects. Another study reported&#xD;
        that the administration of C. sativum leaves improved memory performance and hindered the&#xD;
        aging process in rats in a dose-dependent manner. Furthermore, it was observed that C.&#xD;
        sativum leaves reversed memory impairments induced by scopolamine and diazepam, while also&#xD;
        significantly reducing brain cholinesterase activity and serum total cholesterol levels.&#xD;
        Another study evaluated the effects of the ethanolic extract of C. sativum seeds on learning&#xD;
        in second-generation mice. Although the plant extract did not enhance learning in the short&#xD;
        term following training, it did show improvements in long-term learning. Additionally, in an&#xD;
        animal model of anxiety, the effects of different doses (10 mg/kg, 25 mg/kg, 50 mg/kg, and&#xD;
        100 mg/kg administered intraperitoneally) of the aqueous extract of C. sativum seeds were&#xD;
        evaluated in terms of motor activity and neuromuscular function. In the elevated plus-maze&#xD;
        test, the 100 mg/kg dose of the seeds' aqueous extract exhibited anxiolytic effects by&#xD;
        increasing the time spent in and the number of entries into the open arms.&#xD;
  &#xD;
        Anxiety, depression, and sleep disorders are prevalent among university students, and these&#xD;
        conditions can have a considerable impact on their memory function. Consequently, there has&#xD;
        been a rise in the use of stimulant drugs among university students as a means to enhance&#xD;
        memory performance and attention, despite the fact that such use is unapproved and&#xD;
        non-therapeutic which might be associated with several side effects. As a result, there is a&#xD;
        growing interest among neuroscience researchers to identify cognitive-enhancing drugs that&#xD;
        can be safely used by healthy individuals without adverse effects.&#xD;
  &#xD;
        Given the information provided, it is suggested that C. sativum could potentially serve as a&#xD;
        memory enhancer for university students. It is considered a preferable option to stimulant&#xD;
        drugs due to its safety profile. Additionally, C. sativum may have positive effects on&#xD;
        anxiety, depression, and sleep quality. However, it is important to note that the current&#xD;
        body of research on the effects of oral C. sativum on the brain and nervous system is&#xD;
        limited, and further studies are necessary to fully understand its potential benefits. Thus,&#xD;
        this study aims to assess the impact of oral C. sativum on memory performance, anxiety,&#xD;
        depression, and sleep quality in university students.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Completed</overall_status>
    <start_date type="Actual">March 1, 2022</start_date>
    <completion_date type="Actual">July 1, 2022</completion_date>
    <primary_completion_date type="Actual">July 1, 2022</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>Randomized</allocation>
      <intervention_model>Parallel Assignment</intervention_model>
      <primary_purpose>Supportive Care</primary_purpose>
      <masking>Triple (Participant, Care Provider, Investigator)</masking>
    </study_design_info>
    <primary_outcome>
      <measure>Memory performance</measure>
      <time_frame>30 days</time_frame>
      <description>Prospective and Retrospective Memory Questionnaire was performed</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>Anxiety and depression</measure>
      <time_frame>30 days</time_frame>
      <description>Hospital Anxiety and Depression Scale was perfomed</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Sleep quality</measure>
      <time_frame>30 days</time_frame>
      <description>Pittsburgh Sleep Quality Inventory questionnaire was perfoemed</description>
    </secondary_outcome>
    <number_of_arms>2</number_of_arms>
    <enrollment type="Actual">86</enrollment>
    <condition>Memory Disorders</condition>
    <condition>Anxiety Depression</condition>
    <condition>Sleep</condition>
    <arm_group>
      <arm_group_label>Coriandrum sativum group</arm_group_label>
      <arm_group_type>Experimental</arm_group_type>
      <description>500 mg of C. sativum (capsules) were administered twice daily</description>
    </arm_group>
    <arm_group>
      <arm_group_label>control group</arm_group_label>
      <arm_group_type>Placebo Comparator</arm_group_type>
      <description>500 mg of starch (capsules) were administered twice daily</description>
    </arm_group>
    <intervention>
      <intervention_type>Dietary Supplement</intervention_type>
      <intervention_name>Coriandrum sativum seeds</intervention_name>
      <description>Each group consisted of 50 students. In the C. sativum group, dried powdered seeds of C. sativum were administered, while in the control group, starch was provided as a placebo. Both the C. sativum and placebo capsules were identical in shape, color, and outer packaging to maintain the blinding of the participants.</description>
      <arm_group_label>Coriandrum sativum group</arm_group_label>
      <arm_group_label>control group</arm_group_label>
      <other_name>Coriandrum</other_name>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Male or female university Student.&#xD;
  &#xD;
            -  19-23 of age&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Medical diseases.&#xD;
  &#xD;
            -  Psychiatric disorders.&#xD;
  &#xD;
            -  Using any form of medication (including complementary and alternative medicines).&#xD;
  &#xD;
            -  Pregnant and lactating individuals.&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>19 Years</minimum_age>
      <maximum_age>23 Years</maximum_age>
      <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
    </eligibility>
    <location>
      <facility>
        <name>Faculty of Pharmaceutical Sciences</name>
        <address>
          <city>Zarqa</city>
          <zip>13133</zip>
          <country>Jordan</country>
        </address>
      </facility>
    </location>
    <location_countries>
      <country>Jordan</country>
    </location_countries>
    <verification_date>August 2023</verification_date>
    <study_first_submitted>August 3, 2023</study_first_submitted>
    <study_first_submitted_qc>August 11, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 21, 2023</study_first_posted>
    <last_update_submitted>August 11, 2023</last_update_submitted>
    <last_update_submitted_qc>August 11, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">August 21, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Principal Investigator</responsible_party_type>
      <investigator_affiliation>The Hashemite University</investigator_affiliation>
      <investigator_full_name>Abdelrahim Alqudah</investigator_full_name>
      <investigator_title>Assisstant professor</investigator_title>
    </responsible_party>
    <keyword>Coriandrum sativum</keyword>
    <keyword>memory performance</keyword>
    <keyword>anxiety</keyword>
    <keyword>depression</keyword>
    <keyword>sleep</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Memory Disorders</mesh_term>
      <mesh_term>Depression</mesh_term>
      <mesh_term>Depressive Disorder</mesh_term>
      <mesh_term>Anxiety Disorders</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
      <ipd_description>All participants data will be hidden</ipd_description>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT05999071
  org study id: 21/6/2022/2023
  nct id: NCT05999071
  lead sponsor: 
  is fda regulated drug: No
  is fda regulated device: No
  C. sativum could potentially serve as a memory enhancer for university students. It is
        considered a preferable option to stimulant drugs due to its safety profile. Additionally, C.
        sativum may have positive effects on anxiety, depression, and sleep quality. However, it is
        important to note that the current body of research on the effects of oral C. sativum on the
        brain and nervous system is limited, and further studies are necessary to fully understand
        its potential benefits. Thus, this study aims to assess the impact of oral C. sativum on
        memory performance, anxiety, depression, and sleep quality in university students.
  Coriander, scientifically known as Coriandrum sativum L (C. sativum), is an ancient herb that
        belongs to the Apiaceae family. It has a rich history of more than 3,000 years of use in both
        culinary and medicinal practices. While originally native to Mediterranean regions, coriander
        is now cultivated in various countries worldwide. In traditional medicine, all parts of the
        coriander plant have been consumed and utilized to address gastrointestinal ailments like
        anorexia, dyspepsia, flatulence, diarrhea, pain, and vomiting. In Jordanian traditional
        medicine, C. sativum has been valued for its anticonvulsant, antidepressant, sedative, and
        anxiolytic properties. Studies have reported diverse health benefits associated with C.
        sativum seeds and leaves, including antioxidant, diuretic, cholesterol-lowering, anxiolytic,
        sedative-hypnotic, and anticonvulsant activities. Notably, the main component of C. sativum,
        linalool, along with γ-terpinene and α-pinene, exhibit various neuropharmacological effects,
        such as anti-anxiety, sedative, anticonvulsant, and anti-Alzheimer's disease properties.
        Additionally, C. sativum seeds are recognized as a valuable source of vitamins, lipids, and
        minerals like potassium, calcium, phosphorus, magnesium, sodium, and zinc.
  
        Several studies have indicated the positive effects of C. sativum on memory, anxiety, and
        depression. In a specific study, the aqueous extract derived from the seeds of C. sativum
        demonstrated significant reductions in monoamine oxidase-B (MAO-B) activity over time,
        suggesting its primary role in exerting antidepressant-like effects. Another study reported
        that the administration of C. sativum leaves improved memory performance and hindered the
        aging process in rats in a dose-dependent manner. Furthermore, it was observed that C.
        sativum leaves reversed memory impairments induced by scopolamine and diazepam, while also
        significantly reducing brain cholinesterase activity and serum total cholesterol levels.
        Another study evaluated the effects of the ethanolic extract of C. sativum seeds on learning
        in second-generation mice. Although the plant extract did not enhance learning in the short
        term following training, it did show improvements in long-term learning. Additionally, in an
        animal model of anxiety, the effects of different doses (10 mg/kg, 25 mg/kg, 50 mg/kg, and
        100 mg/kg administered intraperitoneally) of the aqueous extract of C. sativum seeds were
        evaluated in terms of motor activity and neuromuscular function. In the elevated plus-maze
        test, the 100 mg/kg dose of the seeds' aqueous extract exhibited anxiolytic effects by
        increasing the time spent in and the number of entries into the open arms.
  
        Anxiety, depression, and sleep disorders are prevalent among university students, and these
        conditions can have a considerable impact on their memory function. Consequently, there has
        been a rise in the use of stimulant drugs among university students as a means to enhance
        memory performance and attention, despite the fact that such use is unapproved and
        non-therapeutic which might be associated with several side effects. As a result, there is a
        growing interest among neuroscience researchers to identify cognitive-enhancing drugs that
        can be safely used by healthy individuals without adverse effects.
  
        Given the information provided, it is suggested that C. sativum could potentially serve as a
        memory enhancer for university students. It is considered a preferable option to stimulant
        drugs due to its safety profile. Additionally, C. sativum may have positive effects on
        anxiety, depression, and sleep quality. However, it is important to note that the current
        body of research on the effects of oral C. sativum on the brain and nervous system is
        limited, and further studies are necessary to fully understand its potential benefits. Thus,
        this study aims to assess the impact of oral C. sativum on memory performance, anxiety,
        depression, and sleep quality in university students.
  allocation: Randomized
  intervention model: Parallel Assignment
  primary purpose: Supportive Care
  masking: Triple (Participant, Care Provider, Investigator)
  measure: Memory performance
  time frame: 30 days
  description: Prospective and Retrospective Memory Questionnaire was performed
  measure: Anxiety and depression
  time frame: 30 days
  description: Hospital Anxiety and Depression Scale was perfomed
  measure: Sleep quality
  time frame: 30 days
  description: Pittsburgh Sleep Quality Inventory questionnaire was perfoemed
  arm group label: Coriandrum sativum group
  arm group type: Experimental
  description: 500 mg of C. sativum (capsules) were administered twice daily
  arm group label: control group
  arm group type: Placebo Comparator
  description: 500 mg of starch (capsules) were administered twice daily
  intervention type: Dietary Supplement
  intervention name: Coriandrum sativum seeds
  description: Each group consisted of 50 students. In the C. sativum group, dried powdered seeds of C. sativum were administered, while in the control group, starch was provided as a placebo. Both the C. sativum and placebo capsules were identical in shape, color, and outer packaging to maintain the blinding of the participants.
  arm group label: Coriandrum sativum group
  arm group label: control group
  other name: Coriandrum
  criteria: 
  gender: All
  minimum age: 19 Years
  maximum age: 23 Years
  healthy volunteers: Accepts Healthy Volunteers
  facility: 
  country: Jordan
  responsible party type: Principal Investigator
  investigator affiliation: The Hashemite University
  investigator full name: Abdelrahim Alqudah
  investigator title: Assisstant professor
  mesh term: Memory Disorders
  mesh term: Depression
  mesh term: Depressive Disorder
  mesh term: Anxiety Disorders
  sharing ipd: No
  ipd description: All participants data will be hidden