xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT05980780</url>
    </required_header>
    <id_info>
      <org_study_id>2023-KAEK-7</org_study_id>
      <nct_id>NCT05980780</nct_id>
    </id_info>
    <brief_title>The Effect of Video Game on Children With Familial Mediterranean Fever</brief_title>
    <official_title>Video Developed for Children With Familial Mediterranean Fever The Effect of Game on Disease Management and Quality of Life</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Istanbul University - Cerrahpasa (IUC)</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Istanbul University - Cerrahpasa (IUC)</source>
    <oversight_info>
      <has_dmc>Yes</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        This study was planned to be carried out as a pretest-posttest control group design in&#xD;
        experimental type and randomized groups in order to determine the effect of educating&#xD;
        children aged 8-14 with a diagnosis of Familial Mediterranean Fever through a mobile game&#xD;
        application and training booklet on their disease knowledge, disease self-efficacy, symptom&#xD;
        management and quality of life.&#xD;
  &#xD;
        H0: Informing children with Familial Mediterranean Fever through mobile games and educational&#xD;
        booklets has no effect on the child's knowledge of the disease, disease self-efficacy,&#xD;
        symptom management and quality of life.&#xD;
  &#xD;
        Compared to children with Familial Mediterranean Fever who were informed by mobile games, and&#xD;
        children with Familial Mediterranean Fever who were informed through the education booklet&#xD;
        and were not informed at all; H1: Disease knowledge increases. H2: Disease self-efficacy&#xD;
        increases. H3: The number of attacks, activity intolerance, number of symptoms and severity&#xD;
        of pain decrease.&#xD;
  &#xD;
        H4: Quality of life increases.&#xD;
      </textblock>
    </brief_summary>
    <detailed_description>
      <textblock>
        Today, with the ease of access to technological tools, the use of mobile technologies by&#xD;
        children, adolescents and health professionals is becoming increasingly common. These&#xD;
        technologies have begun to change the way healthcare professionals provide healthcare&#xD;
        services, and support children's participation in their own care by providing easy-to-use&#xD;
        digital services. It is emphasized that these technologies, which are accepted with interest&#xD;
        by children and young people, are important new tools in providing health-related behavior&#xD;
        change in children. One of these channels is video games developed for health. The use of&#xD;
        video games in education as a method of children's choice is an important channel that will&#xD;
        enable them to feel that they are in control of their own lives at an earlier age. Thus,&#xD;
        these alternative education methods for children and adolescents can make a difference in&#xD;
        patient education and management of chronic diseases. In the literature, it has been shown&#xD;
        that video games are used and effective in psychotherapy practices and oral and dental health&#xD;
        education, especially in the management of chronic diseases such as diabetes, cancer and&#xD;
        asthma. However, no study has been found on disease self-management and education in children&#xD;
        for Familial Mediterranean Fever, which is very common in our country and continues&#xD;
        throughout life. We think that under the control of Familial Mediterranean Fever, which is a&#xD;
        chronic disease, the child's self-management will manage the disease better, the frequency of&#xD;
        attacks and hospital admissions will decrease, and future complications can be prevented.&#xD;
      </textblock>
    </detailed_description>
    <overall_status>Recruiting</overall_status>
    <start_date type="Actual">July 1, 2023</start_date>
    <completion_date type="Anticipated">July 1, 2024</completion_date>
    <primary_completion_date type="Anticipated">July 1, 2024</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>Randomized</allocation>
      <intervention_model>Parallel Assignment</intervention_model>
      <intervention_model_description>Parallel Assignment</intervention_model_description>
      <primary_purpose>Supportive Care</primary_purpose>
      <masking>Single (Outcomes Assessor)</masking>
      <masking_description>Masking will be used when making the statistical evaluation of the results.</masking_description>
    </study_design_info>
    <primary_outcome>
      <measure>Disease self-efficacy Self-Efficacy Scale for Pediatric Chronic Disease</measure>
      <time_frame>before the intervention, immediately after the intervention, 2 months after the intervention</time_frame>
      <description>The Pediatric Self-Efficacy Scale for Chronic Disease (PRCISE) is an 11-point Likert-type scale consisting of 15 all positive items. The score of each item in the scale ranges from 0 to 10 and consists of statements such as &quot;not sure at all&quot; for 0 and &quot;very sure&quot; for 10. The scale, in which the level of self-efficacy increases as the score increases, is evaluated over 150 points.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Life quality</measure>
      <time_frame>before the intervention, immediately after the intervention, 2 months after the intervention</time_frame>
      <description>A Multi-Dimensional Assessment Scale for Children with Autoinflammatory Disease (JAIMAR) consists of 16 items in total, including assessment of functional skills, pain, compliance with drug use, and quality of life. The measure of quality of life; physical status, social status, school status and emotional status sub-dimensions are available. In addition, the form includes descriptive questions to be used in patient follow-up. In the scale scoring, 5-point Likert-type rating (Never=1, Rarely=2, Sometimes=3, Frequently=4, Always=5) is used in the sub-dimensions of quality of life (physical, social, school and emotional state), and the scoring is 1 It is done from th to 5th. After the average of the answers given to the questions in the criterion is taken, it is rescaled so that the highest score is 10. The quality of life criterion is calculated in the same way by using the average of the questions in all sub-criteria.</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Disease information</measure>
      <time_frame>before the intervention, immediately after the intervention, 2 months after the intervention</time_frame>
      <description>It is a short knowledge test of 11 questions, which was created by researchers and aims to measure disease knowledge. The questions in the test are closed-ended as yes/no, and the child who ticks yes is asked to write an explanation in the adjacent box.</description>
    </primary_outcome>
    <number_of_arms>3</number_of_arms>
    <enrollment type="Anticipated">45</enrollment>
    <condition>FMF</condition>
    <arm_group>
      <arm_group_label>The control group</arm_group_label>
      <arm_group_type>No Intervention</arm_group_type>
      <description>no intervention</description>
    </arm_group>
    <arm_group>
      <arm_group_label>video game group</arm_group_label>
      <arm_group_type>Experimental</arm_group_type>
      <description>Children in this group will play a video game for disease management</description>
    </arm_group>
    <arm_group>
      <arm_group_label>Education booklet group</arm_group_label>
      <arm_group_type>Experimental</arm_group_type>
      <description>Children in this group will read an educational booklet for disease management.</description>
    </arm_group>
    <intervention>
      <intervention_type>Behavioral</intervention_type>
      <intervention_name>video game group</intervention_name>
      <description>Pretest: Participants will be informed about FMF, treatment of FMF, side effects of treatment, factors that trigger attacks, symptoms that occur during the attack, symptom management/disease self-management, and coping with stress through a video game. At the beginning of the application, questions for the collection of demographic data and scales applied to the control group will be applied. The game will be played at home once a week for 1 month. For this, reminder messages will be sent once a week by obtaining the contact information of the mothers.&#xD;
  Post-test 1: The scales will be re-administered 1 month after the pre-test. Post-test 2: The scales will be administered again 3 months after the pre-test.</description>
      <arm_group_label>video game group</arm_group_label>
    </intervention>
    <intervention>
      <intervention_type>Behavioral</intervention_type>
      <intervention_name>Education booklet group</intervention_name>
      <description>Pretest: Participants will be informed about FMF, treatment of FMF, side effects of treatment, factors that trigger attacks, symptoms that occur during the attack, symptom management/disease self-management, and coping with stress through a training booklet. At the beginning of the application, questions for the collection of demographic data and scales applied to the control group will be applied. The booklet will be read at home once a week for 1 month. For this, reminder messages will be sent once a week by obtaining the contact information of the mothers.&#xD;
  Post-test 1: The scales will be re-administered 1 month after the pre-test. Post-test 2: The scales will be administered again 3 months after the pre-test.</description>
      <arm_group_label>Education booklet group</arm_group_label>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Having been diagnosed with FMF (early 1 month)&#xD;
  &#xD;
            -  Taking colchicine medication&#xD;
  &#xD;
            -  Having an attack at least once a year&#xD;
  &#xD;
            -  Willingness to participate in the research&#xD;
  &#xD;
            -  His family's consent to participate in the research&#xD;
  &#xD;
            -  Being literate&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Any identified mental disability&#xD;
  &#xD;
            -  Speech and communication difficulties&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>8 Years</minimum_age>
      <maximum_age>14 Years</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Birsen MUTLU, Phd</last_name>
      <role>Study Director</role>
      <affiliation>Istanbul University - Cerrahpasa (IUC)</affiliation>
    </overall_official>
    <overall_contact>
      <last_name>Gamze KAŞ ALAY, MSc</last_name>
      <phone>+905452827600</phone>
      <email>gamze_37_95@hotmail.com</email>
    </overall_contact>
    <location>
      <facility>
        <name>Istanbul University-Cerrahpasa</name>
        <address>
          <city>Istanbul</city>
          <country>Turkey</country>
        </address>
      </facility>
      <status>Recruiting</status>
      <contact>
        <last_name>Gamze KAŞ ALAY, MSc</last_name>
      </contact>
    </location>
    <location_countries>
      <country>Turkey</country>
    </location_countries>
    <reference>
      <citation>Sparapani VC, Fels S, Kamal N, Ortiz La Banca R, Nascimento LC. A Video Game for Brazilian T1D Children about Knowledge of Disease and Self-care: A Methodological Study. J Diabetes Sci Technol. 2022 Nov;16(6):1444-1450. doi: 10.1177/19322968211017555. Epub 2021 May 28.</citation>
      <PMID>34044626</PMID>
    </reference>
    <reference>
      <citation>Rafeezadeh, E., Ghaemi, N., Miri, H.H., Rezaeian, A., (2019). Effect of an Educational Video Game for Diabetes Self-management on Adherence to a Self-care Regimen in Children with Type 1 Diabetes. Evidence Based Care Journal, 9 (1), 74-83.</citation>
    </reference>
    <reference>
      <citation>Nascimento Lda S, de Gutierrez MG, De Domenico EB. [Educative programs based on self-management: an integrative review]. Rev Gaucha Enferm. 2010 Jun;31(2):375-82. doi: 10.1590/s1983-14472010000200024. Portuguese.</citation>
      <PMID>21500520</PMID>
    </reference>
    <reference>
      <citation>Migita K, Asano T, Sato S, Koga T, Fujita Y, Kawakami A. Familial Mediterranean fever: overview of pathogenesis, clinical features and management. Immunol Med. 2018 Jun;41(2):55-61. doi: 10.1080/13497413.2018.1481579. Epub 2018 Sep 7.</citation>
      <PMID>30938266</PMID>
    </reference>
    <reference>
      <citation>Hentgen V, Grateau G, Kone-Paut I, Livneh A, Padeh S, Rozenbaum M, Amselem S, Gershoni-Baruch R, Touitou I, Ben-Chetrit E. Evidence-based recommendations for the practical management of Familial Mediterranean Fever. Semin Arthritis Rheum. 2013 Dec;43(3):387-91. doi: 10.1016/j.semarthrit.2013.04.011. Epub 2013 Jun 3.</citation>
      <PMID>23742958</PMID>
    </reference>
    <reference>
      <citation>Yildirim DG, Bakkaloglu SA, Acar ASS, Celik B, Buyan N. Evaluation of quality of life and its associations with clinical parameters in pediatric patients with familial Mediterranean fever. North Clin Istanb. 2021 Apr 26;8(3):255-260. doi: 10.14744/nci.2020.90093. eCollection 2021.</citation>
      <PMID>34222806</PMID>
    </reference>
    <reference>
      <citation>Gezgin Yildirim D, Gonen S, Fidan K, Soylemezoglu O. Does Age at Onset Affect the Clinical Presentation of Familial Mediterranean Fever in Children? J Clin Rheumatol. 2022 Jan 1;28(1):e125-e128. doi: 10.1097/RHU.0000000000001637.</citation>
      <PMID>33252389</PMID>
    </reference>
    <reference>
      <citation>Yildirim DG, Bakkaloglu SA, Soysal-Acar AS, Buyan N. Parental knowledge about familial Mediterranean fever: a cross-sectional study. Turk J Pediatr. 2021;63(6):1048-1055. doi: 10.24953/turkjped.2021.06.013.</citation>
      <PMID>35023655</PMID>
    </reference>
    <reference>
      <citation>Durmuş, S.Y., Ozlu, S.G., Cop, E., Bulbul, M. (2022). Health Related Quality of Life of Children Aged 2-18 Years with Familial Mediterranean Fever. Turkish Journal of Pediatric Disease, Elektronik yayın tarihi 24.02.2022 DOI: 10.12956/tchd.1013742</citation>
    </reference>
    <reference>
      <citation>Charlier N, Zupancic N, Fieuws S, Denhaerynck K, Zaman B, Moons P. Serious games for improving knowledge and self-management in young people with chronic conditions: a systematic review and meta-analysis. J Am Med Inform Assoc. 2016 Jan;23(1):230-9. doi: 10.1093/jamia/ocv100. Epub 2015 Jul 17. Erratum In: J Am Med Inform Assoc. 2018 Sep 1;25(9):1270-1271.</citation>
      <PMID>26186934</PMID>
    </reference>
    <reference>
      <citation>Calle-Bustos AM, Juan MC, Garcia-Garcia I, Abad F. An augmented reality game to support therapeutic education for children with diabetes. PLoS One. 2017 Sep 28;12(9):e0184645. doi: 10.1371/journal.pone.0184645. eCollection 2017.</citation>
      <PMID>28957355</PMID>
    </reference>
    <reference>
      <citation>Bravo L, Killela MK, Reyes BL, Santos KMB, Torres V, Huang CC, Jacob E. Self-Management, Self-Efficacy, and Health-Related Quality of Life in Children With Chronic Illness and Medical Complexity. J Pediatr Health Care. 2020 Jul-Aug;34(4):304-314. doi: 10.1016/j.pedhc.2019.11.009. Epub 2020 Feb 25.</citation>
      <PMID>32107073</PMID>
    </reference>
    <reference>
      <citation>Baranowski T, Buday R, Thompson DI, Baranowski J. Playing for real: video games and stories for health-related behavior change. Am J Prev Med. 2008 Jan;34(1):74-82. doi: 10.1016/j.amepre.2007.09.027.</citation>
      <PMID>18083454</PMID>
    </reference>
    <verification_date>July 2023</verification_date>
    <study_first_submitted>July 21, 2023</study_first_submitted>
    <study_first_submitted_qc>July 31, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 8, 2023</study_first_posted>
    <last_update_submitted>July 31, 2023</last_update_submitted>
    <last_update_submitted_qc>July 31, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">August 8, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Principal Investigator</responsible_party_type>
      <investigator_affiliation>Istanbul University - Cerrahpasa (IUC)</investigator_affiliation>
      <investigator_full_name>Gamze Kas Alay</investigator_full_name>
      <investigator_title>Research Assistant</investigator_title>
    </responsible_party>
    <keyword>child</keyword>
    <keyword>mobile game</keyword>
    <keyword>disease management</keyword>
    <keyword>quality of life</keyword>
    <keyword>disease education</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Brucellosis</mesh_term>
      <mesh_term>Familial Mediterranean Fever</mesh_term>
      <mesh_term>Hereditary Autoinflammatory Diseases</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>No</sharing_ipd>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT05980780
  org study id: 2023-KAEK-7
  nct id: NCT05980780
  lead sponsor: 
  has dmc: Yes
  is fda regulated drug: No
  is fda regulated device: No
  This study was planned to be carried out as a pretest-posttest control group design in
        experimental type and randomized groups in order to determine the effect of educating
        children aged 8-14 with a diagnosis of Familial Mediterranean Fever through a mobile game
        application and training booklet on their disease knowledge, disease self-efficacy, symptom
        management and quality of life.
  
        H0: Informing children with Familial Mediterranean Fever through mobile games and educational
        booklets has no effect on the child's knowledge of the disease, disease self-efficacy,
        symptom management and quality of life.
  
        Compared to children with Familial Mediterranean Fever who were informed by mobile games, and
        children with Familial Mediterranean Fever who were informed through the education booklet
        and were not informed at all; H1: Disease knowledge increases. H2: Disease self-efficacy
        increases. H3: The number of attacks, activity intolerance, number of symptoms and severity
        of pain decrease.
  
        H4: Quality of life increases.
  Today, with the ease of access to technological tools, the use of mobile technologies by
        children, adolescents and health professionals is becoming increasingly common. These
        technologies have begun to change the way healthcare professionals provide healthcare
        services, and support children's participation in their own care by providing easy-to-use
        digital services. It is emphasized that these technologies, which are accepted with interest
        by children and young people, are important new tools in providing health-related behavior
        change in children. One of these channels is video games developed for health. The use of
        video games in education as a method of children's choice is an important channel that will
        enable them to feel that they are in control of their own lives at an earlier age. Thus,
        these alternative education methods for children and adolescents can make a difference in
        patient education and management of chronic diseases. In the literature, it has been shown
        that video games are used and effective in psychotherapy practices and oral and dental health
        education, especially in the management of chronic diseases such as diabetes, cancer and
        asthma. However, no study has been found on disease self-management and education in children
        for Familial Mediterranean Fever, which is very common in our country and continues
        throughout life. We think that under the control of Familial Mediterranean Fever, which is a
        chronic disease, the child's self-management will manage the disease better, the frequency of
        attacks and hospital admissions will decrease, and future complications can be prevented.
  allocation: Randomized
  intervention model: Parallel Assignment
  intervention model description: Parallel Assignment
  primary purpose: Supportive Care
  masking: Single (Outcomes Assessor)
  masking description: Masking will be used when making the statistical evaluation of the results.
  measure: Disease self-efficacy Self-Efficacy Scale for Pediatric Chronic Disease
  time frame: before the intervention, immediately after the intervention, 2 months after the intervention
  description: The Pediatric Self-Efficacy Scale for Chronic Disease (PRCISE) is an 11-point Likert-type scale consisting of 15 all positive items. The score of each item in the scale ranges from 0 to 10 and consists of statements such as "not sure at all" for 0 and "very sure" for 10. The scale, in which the level of self-efficacy increases as the score increases, is evaluated over 150 points.
  measure: Life quality
  time frame: before the intervention, immediately after the intervention, 2 months after the intervention
  description: A Multi-Dimensional Assessment Scale for Children with Autoinflammatory Disease (JAIMAR) consists of 16 items in total, including assessment of functional skills, pain, compliance with drug use, and quality of life. The measure of quality of life; physical status, social status, school status and emotional status sub-dimensions are available. In addition, the form includes descriptive questions to be used in patient follow-up. In the scale scoring, 5-point Likert-type rating (Never=1, Rarely=2, Sometimes=3, Frequently=4, Always=5) is used in the sub-dimensions of quality of life (physical, social, school and emotional state), and the scoring is 1 It is done from th to 5th. After the average of the answers given to the questions in the criterion is taken, it is rescaled so that the highest score is 10. The quality of life criterion is calculated in the same way by using the average of the questions in all sub-criteria.
  measure: Disease information
  time frame: before the intervention, immediately after the intervention, 2 months after the intervention
  description: It is a short knowledge test of 11 questions, which was created by researchers and aims to measure disease knowledge. The questions in the test are closed-ended as yes/no, and the child who ticks yes is asked to write an explanation in the adjacent box.
  arm group label: The control group
  arm group type: No Intervention
  description: no intervention
  arm group label: video game group
  arm group type: Experimental
  description: Children in this group will play a video game for disease management
  arm group label: Education booklet group
  arm group type: Experimental
  description: Children in this group will read an educational booklet for disease management.
  intervention type: Behavioral
  intervention name: video game group
  description: Pretest: Participants will be informed about FMF, treatment of FMF, side effects of treatment, factors that trigger attacks, symptoms that occur during the attack, symptom management/disease self-management, and coping with stress through a video game. At the beginning of the application, questions for the collection of demographic data and scales applied to the control group will be applied. The game will be played at home once a week for 1 month. For this, reminder messages will be sent once a week by obtaining the contact information of the mothers.
  Post-test 1: The scales will be re-administered 1 month after the pre-test. Post-test 2: The scales will be administered again 3 months after the pre-test.
  arm group label: video game group
  intervention type: Behavioral
  intervention name: Education booklet group
  description: Pretest: Participants will be informed about FMF, treatment of FMF, side effects of treatment, factors that trigger attacks, symptoms that occur during the attack, symptom management/disease self-management, and coping with stress through a training booklet. At the beginning of the application, questions for the collection of demographic data and scales applied to the control group will be applied. The booklet will be read at home once a week for 1 month. For this, reminder messages will be sent once a week by obtaining the contact information of the mothers.
  Post-test 1: The scales will be re-administered 1 month after the pre-test. Post-test 2: The scales will be administered again 3 months after the pre-test.
  arm group label: Education booklet group
  criteria: 
  gender: All
  minimum age: 8 Years
  maximum age: 14 Years
  healthy volunteers: No
  last name: Birsen MUTLU, Phd
  role: Study Director
  affiliation: Istanbul University - Cerrahpasa (IUC)
  last name: Gamze KAŞ ALAY, MSc
  phone: +905452827600
  email: gamze_37_95@hotmail.com
  facility: 
  status: Recruiting
  contact: 
  country: Turkey
  citation: Sparapani VC, Fels S, Kamal N, Ortiz La Banca R, Nascimento LC. A Video Game for Brazilian T1D Children about Knowledge of Disease and Self-care: A Methodological Study. J Diabetes Sci Technol. 2022 Nov;16(6):1444-1450. doi: 10.1177/19322968211017555. Epub 2021 May 28.
  PMID: 34044626
  citation: Rafeezadeh, E., Ghaemi, N., Miri, H.H., Rezaeian, A., (2019). Effect of an Educational Video Game for Diabetes Self-management on Adherence to a Self-care Regimen in Children with Type 1 Diabetes. Evidence Based Care Journal, 9 (1), 74-83.
  citation: Nascimento Lda S, de Gutierrez MG, De Domenico EB. [Educative programs based on self-management: an integrative review]. Rev Gaucha Enferm. 2010 Jun;31(2):375-82. doi: 10.1590/s1983-14472010000200024. Portuguese.
  PMID: 21500520
  citation: Migita K, Asano T, Sato S, Koga T, Fujita Y, Kawakami A. Familial Mediterranean fever: overview of pathogenesis, clinical features and management. Immunol Med. 2018 Jun;41(2):55-61. doi: 10.1080/13497413.2018.1481579. Epub 2018 Sep 7.
  PMID: 30938266
  citation: Hentgen V, Grateau G, Kone-Paut I, Livneh A, Padeh S, Rozenbaum M, Amselem S, Gershoni-Baruch R, Touitou I, Ben-Chetrit E. Evidence-based recommendations for the practical management of Familial Mediterranean Fever. Semin Arthritis Rheum. 2013 Dec;43(3):387-91. doi: 10.1016/j.semarthrit.2013.04.011. Epub 2013 Jun 3.
  PMID: 23742958
  citation: Yildirim DG, Bakkaloglu SA, Acar ASS, Celik B, Buyan N. Evaluation of quality of life and its associations with clinical parameters in pediatric patients with familial Mediterranean fever. North Clin Istanb. 2021 Apr 26;8(3):255-260. doi: 10.14744/nci.2020.90093. eCollection 2021.
  PMID: 34222806
  citation: Gezgin Yildirim D, Gonen S, Fidan K, Soylemezoglu O. Does Age at Onset Affect the Clinical Presentation of Familial Mediterranean Fever in Children? J Clin Rheumatol. 2022 Jan 1;28(1):e125-e128. doi: 10.1097/RHU.0000000000001637.
  PMID: 33252389
  citation: Yildirim DG, Bakkaloglu SA, Soysal-Acar AS, Buyan N. Parental knowledge about familial Mediterranean fever: a cross-sectional study. Turk J Pediatr. 2021;63(6):1048-1055. doi: 10.24953/turkjped.2021.06.013.
  PMID: 35023655
  citation: Durmuş, S.Y., Ozlu, S.G., Cop, E., Bulbul, M. (2022). Health Related Quality of Life of Children Aged 2-18 Years with Familial Mediterranean Fever. Turkish Journal of Pediatric Disease, Elektronik yayın tarihi 24.02.2022 DOI: 10.12956/tchd.1013742
  citation: Charlier N, Zupancic N, Fieuws S, Denhaerynck K, Zaman B, Moons P. Serious games for improving knowledge and self-management in young people with chronic conditions: a systematic review and meta-analysis. J Am Med Inform Assoc. 2016 Jan;23(1):230-9. doi: 10.1093/jamia/ocv100. Epub 2015 Jul 17. Erratum In: J Am Med Inform Assoc. 2018 Sep 1;25(9):1270-1271.
  PMID: 26186934
  citation: Calle-Bustos AM, Juan MC, Garcia-Garcia I, Abad F. An augmented reality game to support therapeutic education for children with diabetes. PLoS One. 2017 Sep 28;12(9):e0184645. doi: 10.1371/journal.pone.0184645. eCollection 2017.
  PMID: 28957355
  citation: Bravo L, Killela MK, Reyes BL, Santos KMB, Torres V, Huang CC, Jacob E. Self-Management, Self-Efficacy, and Health-Related Quality of Life in Children With Chronic Illness and Medical Complexity. J Pediatr Health Care. 2020 Jul-Aug;34(4):304-314. doi: 10.1016/j.pedhc.2019.11.009. Epub 2020 Feb 25.
  PMID: 32107073
  citation: Baranowski T, Buday R, Thompson DI, Baranowski J. Playing for real: video games and stories for health-related behavior change. Am J Prev Med. 2008 Jan;34(1):74-82. doi: 10.1016/j.amepre.2007.09.027.
  PMID: 18083454
  responsible party type: Principal Investigator
  investigator affiliation: Istanbul University - Cerrahpasa (IUC)
  investigator full name: Gamze Kas Alay
  investigator title: Research Assistant
  mesh term: Brucellosis
  mesh term: Familial Mediterranean Fever
  mesh term: Hereditary Autoinflammatory Diseases
  sharing ipd: No