xml: <clinical_study>
    <!-- This xml conforms to an XML Schema at:
      https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
    <required_header>
      <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
      <link_text>Link to the current ClinicalTrials.gov record.</link_text>
      <url>https://clinicaltrials.gov/ct2/show/NCT05984160</url>
    </required_header>
    <id_info>
      <org_study_id>E-22686390-050.99-27043</org_study_id>
      <nct_id>NCT05984160</nct_id>
    </id_info>
    <brief_title>Efficacy of Paragastric Neural Block Procedure on Postoperative Pain in Patients Who Underwent Sleeve Gastrectomy</brief_title>
    <official_title>Efficacy and Safety of Paragastric Neural Block in Controlling Pain, Nausea and Vomiting After Laparoscopic Sleeve Gastrectomy; Prospective Randomized Controlled Double-blind Study</official_title>
    <sponsors>
      <lead_sponsor>
        <agency>Atlas University</agency>
        <agency_class>Other</agency_class>
      </lead_sponsor>
    </sponsors>
    <source>Atlas University</source>
    <oversight_info>
      <has_dmc>No</has_dmc>
      <is_fda_regulated_drug>No</is_fda_regulated_drug>
      <is_fda_regulated_device>No</is_fda_regulated_device>
    </oversight_info>
    <brief_summary>
      <textblock>
        Surgical treatment is the most effective way to achieve effective and sustainable weight loss&#xD;
        in patients with obesity and to improve the comorbidities caused by it.&#xD;
  &#xD;
        Although minimally invasive bariatric surgical procedures are applied today, postoperative&#xD;
        pain is one of the most basic problems. Opioid-derived drugs used for pain control cause&#xD;
        respiratory depression and constipation. Enhanced Recovery After Surgery (ERAS) protocols&#xD;
        recommend reducing opioid use after bariatric surgery to help patients have a healthier&#xD;
        postoperative period.&#xD;
  &#xD;
        Different methods such as transversus abdominis plane (TAP) block and erector spinae plane&#xD;
        (ESP) block are used to reduce the postoperative opioid dose and for effective pain control.&#xD;
        While these methods are effective in controlling somatic pain, they have no effect on&#xD;
        visceral pain.&#xD;
  &#xD;
        It has been shown that patients' pain and opioid consumption decrease especially after celiac&#xD;
        plexus block. Vagal and sympathetic afferent stimuli from the gastrointestinal tract, on the&#xD;
        other hand, stimulate the vomiting center and cause nausea and vomiting. Paragastric neural&#xD;
        block is a new method performed by injecting local anesthetic into the posterosuperior&#xD;
        paragastric area in the area covering the left gastric artery by revealing the&#xD;
        esophagogastric junction, proximal stomach, middle of the stomach, distal antrum,&#xD;
        hepatoduodenal ligament and stomach posterior along the border of the lesser omentum. In this&#xD;
        way, it is aimed to prevent both visceral pain and the symptoms of nausea and vomiting.&#xD;
  &#xD;
        In our study, the investigators aimed to evaluate the efficacy and safety of paragastric&#xD;
        nerve block applied during laparoscopic sleeve gastrectomy by comparing it with the control&#xD;
        group.&#xD;
      </textblock>
    </brief_summary>
    <overall_status>Active, not recruiting</overall_status>
    <start_date type="Actual">May 9, 2023</start_date>
    <completion_date type="Anticipated">August 10, 2023</completion_date>
    <primary_completion_date type="Anticipated">August 1, 2023</primary_completion_date>
    <phase>N/A</phase>
    <study_type>Interventional</study_type>
    <has_expanded_access>No</has_expanded_access>
    <study_design_info>
      <allocation>Randomized</allocation>
      <intervention_model>Parallel Assignment</intervention_model>
      <intervention_model_description>The patients were divided into two groups as perigastric neural block and control group.</intervention_model_description>
      <primary_purpose>Treatment</primary_purpose>
      <masking>Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)</masking>
      <masking_description>Randomization was performed by a general surgeon who would not be present during the block procedure. Patients were numbered sequentially according to the randomization scheme. Patient numbers were recorded in the follow-up files. Evaluation of the postoperative results was done by a general surgeon who was unaware of the group distributions. Since both the patients and the general surgeon who will make the evaluation did not know whether the block procedure was applied or not, the study was performed as double-blind.</masking_description>
    </study_design_info>
    <primary_outcome>
      <measure>Postoperative pain</measure>
      <time_frame>In first 24 hours</time_frame>
      <description>The investigators used visual analog scale. Minimum value 0 (means no pain), maximum values 10 (means worst pain ever).</description>
    </primary_outcome>
    <primary_outcome>
      <measure>Postoperative nause and vomiting</measure>
      <time_frame>In first 24 hours</time_frame>
      <description>The investigators used Post operative nause and vomiting impact scale. Minimum value 0, maximum values 6. Total score &gt;4 defines clinically important postoperative nause and vomiting.</description>
    </primary_outcome>
    <secondary_outcome>
      <measure>First Rescue analgesia</measure>
      <time_frame>In first 24 hours</time_frame>
      <description>Did patients need first rescue analgesia?</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Second Rescue analgesia</measure>
      <time_frame>In first 24 hours</time_frame>
      <description>Did patients need second rescue analgesia?</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Rescue antiemetic</measure>
      <time_frame>In first 24 hours</time_frame>
      <description>Did patients need rescue antiemetic drug?</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Time to rescue antiemetic</measure>
      <time_frame>In first 24 hours</time_frame>
      <description>When patients need rescue antiemetic drug?</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Time to first rescue analgesia</measure>
      <time_frame>In first 24 hours</time_frame>
      <description>When patients need first rescue analgesia?</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Time to second rescue analgesia</measure>
      <time_frame>In first 24 hours</time_frame>
      <description>when patients need second rescue analgesia?</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>First mobilization time</measure>
      <time_frame>In first 24 hours</time_frame>
      <description>When patients start to walk?</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Operation time</measure>
      <time_frame>Through operation completion, an avarage of 1 hour</time_frame>
      <description>How long did the surgery take?</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Patient satisfaction</measure>
      <time_frame>In first 72 hours</time_frame>
      <description>The investigators used likert scale. Minimum value 1 (very unsatisfied), maximum values 5 (very satisfied).</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Pulse before block</measure>
      <time_frame>at block moment</time_frame>
      <description>Pulse before block</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Pulse 10 minutes after the block</measure>
      <time_frame>10 minutes after the block</time_frame>
      <description>Pulse 10 minutes after the block</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Sistolic blood pressure before the block</measure>
      <time_frame>at block moment</time_frame>
      <description>Sistolic blood pressure before the block</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Sistolic blood pressure 10 minutes after the block</measure>
      <time_frame>10 minutes after the block</time_frame>
      <description>Sistolic blood pressure 10 minutes after the block</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Diastolic blood pressure before the block</measure>
      <time_frame>at block moment</time_frame>
      <description>Diastolic blood pressure before the block</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Diastolic blood pressure 10 minutes after the block</measure>
      <time_frame>10 minutes after the block</time_frame>
      <description>Diastolic blood pressure 10 minutes after the block</description>
    </secondary_outcome>
    <secondary_outcome>
      <measure>Complication at the block site</measure>
      <time_frame>Through operation, an avarage of 1 hour</time_frame>
      <description>Were there any complications during the block?</description>
    </secondary_outcome>
    <number_of_arms>2</number_of_arms>
    <enrollment type="Actual">90</enrollment>
    <condition>Obesity</condition>
    <condition>Post Operative Pain</condition>
    <arm_group>
      <arm_group_label>Paragastric neural block</arm_group_label>
      <arm_group_type>Active Comparator</arm_group_type>
      <description>Patients who were operated for sleeve gastrectomy were included in the study. Afterwards, they were divided into two groups. While pragastric neural block was applied to one group, no intervention was made to the other group.</description>
    </arm_group>
    <arm_group>
      <arm_group_label>Control</arm_group_label>
      <arm_group_type>No Intervention</arm_group_type>
      <description>Control grup</description>
    </arm_group>
    <intervention>
      <intervention_type>Other</intervention_type>
      <intervention_name>Paragastric neural block</intervention_name>
      <description>A block method used to control patients' symptoms of pain, nausea and vomiting after surgery.</description>
      <arm_group_label>Paragastric neural block</arm_group_label>
    </intervention>
    <eligibility>
      <criteria>
        <textblock>
          Inclusion Criteria:&#xD;
  &#xD;
            -  Body mass index of over 35 and an obesity-related comorbidity,&#xD;
  &#xD;
            -  Body mass index of over 40,&#xD;
  &#xD;
            -  Patients who underwent laparoscopic sleeve gastrectomy,&#xD;
  &#xD;
            -  ASA risk score of 2-3,&#xD;
  &#xD;
            -  Agreed to be included in the study.&#xD;
  &#xD;
          Exclusion Criteria:&#xD;
  &#xD;
            -  Chronic pain disorder or using gabapentin,&#xD;
  &#xD;
            -  Opioid addicts,&#xD;
  &#xD;
            -  Using anticoagulant drugs,&#xD;
  &#xD;
            -  History of previous upper gastrointestinal system surgery,&#xD;
  &#xD;
            -  Surgical complications during or after surgery,&#xD;
  &#xD;
            -  Hepatic or renal failure,&#xD;
  &#xD;
            -  Moderate or severe cardiovascular or respiratory disease,&#xD;
  &#xD;
            -  Allergy to the local anesthetic agent to be applied for the block,&#xD;
  &#xD;
            -  Limited cooperation,&#xD;
  &#xD;
            -  More than one surgical intervention in the same session,&#xD;
  &#xD;
            -  Allergy to the drugs to be used in the postoperative treatment protocol.&#xD;
        </textblock>
      </criteria>
      <gender>All</gender>
      <minimum_age>18 Years</minimum_age>
      <maximum_age>65 Years</maximum_age>
      <healthy_volunteers>No</healthy_volunteers>
    </eligibility>
    <overall_official>
      <last_name>Mehmet K Katar, Assoc.Prof.</last_name>
      <role>Principal Investigator</role>
      <affiliation>Atlas University</affiliation>
    </overall_official>
    <location>
      <facility>
        <name>Atlas university</name>
        <address>
          <city>Istanbul</city>
          <country>Turkey</country>
        </address>
      </facility>
    </location>
    <location_countries>
      <country>Turkey</country>
    </location_countries>
    <reference>
      <citation>Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Al Mamun A, Bonneux L; NEDCOM, the Netherlands Epidemiology and Demography Compression of Morbidity Research Group. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med. 2003 Jan 7;138(1):24-32. doi: 10.7326/0003-4819-138-1-200301070-00008.</citation>
      <PMID>12513041</PMID>
    </reference>
    <reference>
      <citation>Arterburn DE, Olsen MK, Smith VA, Livingston EH, Van Scoyoc L, Yancy WS Jr, Eid G, Weidenbacher H, Maciejewski ML. Association between bariatric surgery and long-term survival. JAMA. 2015 Jan 6;313(1):62-70. doi: 10.1001/jama.2014.16968.</citation>
      <PMID>25562267</PMID>
    </reference>
    <reference>
      <citation>Liu JJ, Brenner DM. Opioid-Related Constipation. Gastroenterol Clin North Am. 2022 Mar;51(1):107-121. doi: 10.1016/j.gtc.2021.10.007. Epub 2022 Jan 8.</citation>
      <PMID>35135657</PMID>
    </reference>
    <reference>
      <citation>Budiansky AS, Margarson MP, Eipe N. Acute pain management in morbid obesity - an evidence based clinical update. Surg Obes Relat Dis. 2017 Mar;13(3):523-532. doi: 10.1016/j.soard.2016.09.013. Epub 2016 Sep 19.</citation>
      <PMID>27771314</PMID>
    </reference>
    <reference>
      <citation>Stenberg E, Dos Reis Falcao LF, O'Kane M, Liem R, Pournaras DJ, Salminen P, Urman RD, Wadhwa A, Gustafsson UO, Thorell A. Guidelines for Perioperative Care in Bariatric Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations: A 2021 Update. World J Surg. 2022 Apr;46(4):729-751. doi: 10.1007/s00268-021-06394-9. Epub 2022 Jan 4. Erratum In: World J Surg. 2022 Jan 29;:</citation>
      <PMID>34984504</PMID>
    </reference>
    <reference>
      <citation>Emile SH, Abdel-Razik MA, Elbahrawy K, Elshobaky A, Shalaby M, Elbaz SA, Gado WA, Elbanna HG. Impact of Ultrasound-Guided Transversus Abdominis Plane Block on Postoperative Pain and Early Outcome After Laparoscopic Bariatric Surgery: a Randomized Double-Blinded Controlled Trial. Obes Surg. 2019 May;29(5):1534-1541. doi: 10.1007/s11695-019-03720-y.</citation>
      <PMID>30706309</PMID>
    </reference>
    <reference>
      <citation>Zengin SU, Ergun MO, Gunal O. Effect of Ultrasound-Guided Erector Spinae Plane Block on Postoperative Pain and Intraoperative Opioid Consumption in Bariatric Surgery. Obes Surg. 2021 Dec;31(12):5176-5182. doi: 10.1007/s11695-021-05681-7. Epub 2021 Aug 27.</citation>
      <PMID>34449029</PMID>
    </reference>
    <reference>
      <citation>Daes J, Morrell DJ, Hanssen A, Caballero M, Luque E, Pantoja R, Luquetta J, Pauli EM. Paragastric Autonomic Neural Blockade to Prevent Early Visceral Pain and Associated Symptoms After Laparoscopic Sleeve Gastrectomy: a Randomized Clinical Trial. Obes Surg. 2022 Nov;32(11):3551-3560. doi: 10.1007/s11695-022-06257-9. Epub 2022 Sep 2.</citation>
      <PMID>36050617</PMID>
    </reference>
    <reference>
      <citation>Kambadakone A, Thabet A, Gervais DA, Mueller PR, Arellano RS. CT-guided celiac plexus neurolysis: a review of anatomy, indications, technique, and tips for successful treatment. Radiographics. 2011 Oct;31(6):1599-621. doi: 10.1148/rg.316115526.</citation>
      <PMID>21997984</PMID>
    </reference>
    <reference>
      <citation>Rana MV, Candido KD, Raja O, Knezevic NN. Celiac plexus block in the management of chronic abdominal pain. Curr Pain Headache Rep. 2014 Feb;18(2):394. doi: 10.1007/s11916-013-0394-z.</citation>
      <PMID>24414338</PMID>
    </reference>
    <verification_date>July 2023</verification_date>
    <study_first_submitted>July 18, 2023</study_first_submitted>
    <study_first_submitted_qc>July 31, 2023</study_first_submitted_qc>
    <study_first_posted type="Actual">August 9, 2023</study_first_posted>
    <last_update_submitted>July 31, 2023</last_update_submitted>
    <last_update_submitted_qc>July 31, 2023</last_update_submitted_qc>
    <last_update_posted type="Actual">August 9, 2023</last_update_posted>
    <responsible_party>
      <responsible_party_type>Sponsor</responsible_party_type>
    </responsible_party>
    <keyword>Obesity</keyword>
    <keyword>Post operative pain</keyword>
    <keyword>Pain block</keyword>
    <keyword>Sleeve gastrectomy</keyword>
    <condition_browse>
      <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
      <mesh_term>Pain, Postoperative</mesh_term>
    </condition_browse>
    <patient_data>
      <sharing_ipd>Yes</sharing_ipd>
      <ipd_description>Data will be shared after the article is published.</ipd_description>
      <ipd_info_type>Study Protocol</ipd_info_type>
      <ipd_info_type>Statistical Analysis Plan (SAP)</ipd_info_type>
      <ipd_info_type>Informed Consent Form (ICF)</ipd_info_type>
      <ipd_time_frame>Start after the publication.</ipd_time_frame>
      <ipd_access_criteria>All results of working can be shared with researchers after the study is published.</ipd_access_criteria>
    </patient_data>
    <!-- Results have not yet been posted for this study                                          -->
  </clinical_study>
  
  
text: download date: ClinicalTrials.gov processed this data on September 20, 2023
  link text: Link to the current ClinicalTrials.gov record.
  url: https://clinicaltrials.gov/ct2/show/NCT05984160
  org study id: E-22686390-050.99-27043
  nct id: NCT05984160
  lead sponsor: 
  has dmc: No
  is fda regulated drug: No
  is fda regulated device: No
  Surgical treatment is the most effective way to achieve effective and sustainable weight loss
        in patients with obesity and to improve the comorbidities caused by it.
  
        Although minimally invasive bariatric surgical procedures are applied today, postoperative
        pain is one of the most basic problems. Opioid-derived drugs used for pain control cause
        respiratory depression and constipation. Enhanced Recovery After Surgery (ERAS) protocols
        recommend reducing opioid use after bariatric surgery to help patients have a healthier
        postoperative period.
  
        Different methods such as transversus abdominis plane (TAP) block and erector spinae plane
        (ESP) block are used to reduce the postoperative opioid dose and for effective pain control.
        While these methods are effective in controlling somatic pain, they have no effect on
        visceral pain.
  
        It has been shown that patients' pain and opioid consumption decrease especially after celiac
        plexus block. Vagal and sympathetic afferent stimuli from the gastrointestinal tract, on the
        other hand, stimulate the vomiting center and cause nausea and vomiting. Paragastric neural
        block is a new method performed by injecting local anesthetic into the posterosuperior
        paragastric area in the area covering the left gastric artery by revealing the
        esophagogastric junction, proximal stomach, middle of the stomach, distal antrum,
        hepatoduodenal ligament and stomach posterior along the border of the lesser omentum. In this
        way, it is aimed to prevent both visceral pain and the symptoms of nausea and vomiting.
  
        In our study, the investigators aimed to evaluate the efficacy and safety of paragastric
        nerve block applied during laparoscopic sleeve gastrectomy by comparing it with the control
        group.
  allocation: Randomized
  intervention model: Parallel Assignment
  intervention model description: The patients were divided into two groups as perigastric neural block and control group.
  primary purpose: Treatment
  masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  masking description: Randomization was performed by a general surgeon who would not be present during the block procedure. Patients were numbered sequentially according to the randomization scheme. Patient numbers were recorded in the follow-up files. Evaluation of the postoperative results was done by a general surgeon who was unaware of the group distributions. Since both the patients and the general surgeon who will make the evaluation did not know whether the block procedure was applied or not, the study was performed as double-blind.
  measure: Postoperative pain
  time frame: In first 24 hours
  description: The investigators used visual analog scale. Minimum value 0 (means no pain), maximum values 10 (means worst pain ever).
  measure: Postoperative nause and vomiting
  time frame: In first 24 hours
  description: The investigators used Post operative nause and vomiting impact scale. Minimum value 0, maximum values 6. Total score >4 defines clinically important postoperative nause and vomiting.
  measure: First Rescue analgesia
  time frame: In first 24 hours
  description: Did patients need first rescue analgesia?
  measure: Second Rescue analgesia
  time frame: In first 24 hours
  description: Did patients need second rescue analgesia?
  measure: Rescue antiemetic
  time frame: In first 24 hours
  description: Did patients need rescue antiemetic drug?
  measure: Time to rescue antiemetic
  time frame: In first 24 hours
  description: When patients need rescue antiemetic drug?
  measure: Time to first rescue analgesia
  time frame: In first 24 hours
  description: When patients need first rescue analgesia?
  measure: Time to second rescue analgesia
  time frame: In first 24 hours
  description: when patients need second rescue analgesia?
  measure: First mobilization time
  time frame: In first 24 hours
  description: When patients start to walk?
  measure: Operation time
  time frame: Through operation completion, an avarage of 1 hour
  description: How long did the surgery take?
  measure: Patient satisfaction
  time frame: In first 72 hours
  description: The investigators used likert scale. Minimum value 1 (very unsatisfied), maximum values 5 (very satisfied).
  measure: Pulse before block
  time frame: at block moment
  description: Pulse before block
  measure: Pulse 10 minutes after the block
  time frame: 10 minutes after the block
  description: Pulse 10 minutes after the block
  measure: Sistolic blood pressure before the block
  time frame: at block moment
  description: Sistolic blood pressure before the block
  measure: Sistolic blood pressure 10 minutes after the block
  time frame: 10 minutes after the block
  description: Sistolic blood pressure 10 minutes after the block
  measure: Diastolic blood pressure before the block
  time frame: at block moment
  description: Diastolic blood pressure before the block
  measure: Diastolic blood pressure 10 minutes after the block
  time frame: 10 minutes after the block
  description: Diastolic blood pressure 10 minutes after the block
  measure: Complication at the block site
  time frame: Through operation, an avarage of 1 hour
  description: Were there any complications during the block?
  arm group label: Paragastric neural block
  arm group type: Active Comparator
  description: Patients who were operated for sleeve gastrectomy were included in the study. Afterwards, they were divided into two groups. While pragastric neural block was applied to one group, no intervention was made to the other group.
  arm group label: Control
  arm group type: No Intervention
  description: Control grup
  intervention type: Other
  intervention name: Paragastric neural block
  description: A block method used to control patients' symptoms of pain, nausea and vomiting after surgery.
  arm group label: Paragastric neural block
  criteria: 
  gender: All
  minimum age: 18 Years
  maximum age: 65 Years
  healthy volunteers: No
  last name: Mehmet K Katar, Assoc.Prof.
  role: Principal Investigator
  affiliation: Atlas University
  facility: 
  country: Turkey
  citation: Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Al Mamun A, Bonneux L; NEDCOM, the Netherlands Epidemiology and Demography Compression of Morbidity Research Group. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med. 2003 Jan 7;138(1):24-32. doi: 10.7326/0003-4819-138-1-200301070-00008.
  PMID: 12513041
  citation: Arterburn DE, Olsen MK, Smith VA, Livingston EH, Van Scoyoc L, Yancy WS Jr, Eid G, Weidenbacher H, Maciejewski ML. Association between bariatric surgery and long-term survival. JAMA. 2015 Jan 6;313(1):62-70. doi: 10.1001/jama.2014.16968.
  PMID: 25562267
  citation: Liu JJ, Brenner DM. Opioid-Related Constipation. Gastroenterol Clin North Am. 2022 Mar;51(1):107-121. doi: 10.1016/j.gtc.2021.10.007. Epub 2022 Jan 8.
  PMID: 35135657
  citation: Budiansky AS, Margarson MP, Eipe N. Acute pain management in morbid obesity - an evidence based clinical update. Surg Obes Relat Dis. 2017 Mar;13(3):523-532. doi: 10.1016/j.soard.2016.09.013. Epub 2016 Sep 19.
  PMID: 27771314
  citation: Stenberg E, Dos Reis Falcao LF, O'Kane M, Liem R, Pournaras DJ, Salminen P, Urman RD, Wadhwa A, Gustafsson UO, Thorell A. Guidelines for Perioperative Care in Bariatric Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations: A 2021 Update. World J Surg. 2022 Apr;46(4):729-751. doi: 10.1007/s00268-021-06394-9. Epub 2022 Jan 4. Erratum In: World J Surg. 2022 Jan 29;:
  PMID: 34984504
  citation: Emile SH, Abdel-Razik MA, Elbahrawy K, Elshobaky A, Shalaby M, Elbaz SA, Gado WA, Elbanna HG. Impact of Ultrasound-Guided Transversus Abdominis Plane Block on Postoperative Pain and Early Outcome After Laparoscopic Bariatric Surgery: a Randomized Double-Blinded Controlled Trial. Obes Surg. 2019 May;29(5):1534-1541. doi: 10.1007/s11695-019-03720-y.
  PMID: 30706309
  citation: Zengin SU, Ergun MO, Gunal O. Effect of Ultrasound-Guided Erector Spinae Plane Block on Postoperative Pain and Intraoperative Opioid Consumption in Bariatric Surgery. Obes Surg. 2021 Dec;31(12):5176-5182. doi: 10.1007/s11695-021-05681-7. Epub 2021 Aug 27.
  PMID: 34449029
  citation: Daes J, Morrell DJ, Hanssen A, Caballero M, Luque E, Pantoja R, Luquetta J, Pauli EM. Paragastric Autonomic Neural Blockade to Prevent Early Visceral Pain and Associated Symptoms After Laparoscopic Sleeve Gastrectomy: a Randomized Clinical Trial. Obes Surg. 2022 Nov;32(11):3551-3560. doi: 10.1007/s11695-022-06257-9. Epub 2022 Sep 2.
  PMID: 36050617
  citation: Kambadakone A, Thabet A, Gervais DA, Mueller PR, Arellano RS. CT-guided celiac plexus neurolysis: a review of anatomy, indications, technique, and tips for successful treatment. Radiographics. 2011 Oct;31(6):1599-621. doi: 10.1148/rg.316115526.
  PMID: 21997984
  citation: Rana MV, Candido KD, Raja O, Knezevic NN. Celiac plexus block in the management of chronic abdominal pain. Curr Pain Headache Rep. 2014 Feb;18(2):394. doi: 10.1007/s11916-013-0394-z.
  PMID: 24414338
  responsible party type: Sponsor
  mesh term: Pain, Postoperative
  sharing ipd: Yes
  ipd description: Data will be shared after the article is published.
  ipd info type: Study Protocol
  ipd info type: Statistical Analysis Plan (SAP)
  ipd info type: Informed Consent Form (ICF)
  ipd time frame: Start after the publication.
  ipd access criteria: All results of working can be shared with researchers after the study is published.