<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04502654</url>
  </required_header>
  <id_info>
    <org_study_id>H-20041489</org_study_id>
    <nct_id>NCT04502654</nct_id>
  </id_info>
  <brief_title>Rehabilitation for Thoracoscopic Lobectomy</brief_title>
  <official_title>Postoperative Functional Recovery After Fast-track VATS Lobectomy</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Rigshospitalet, Denmark</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Rigshospitalet, Denmark</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The main aim of this research is to compare the functional recovery after discharge with the&#xD;
      preoperative physical activity as a hypothesis generating study.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">September 15, 2020</start_date>
  <completion_date type="Actual">July 21, 2021</completion_date>
  <primary_completion_date type="Actual">July 21, 2021</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Length of functional rehabilitation</measure>
    <time_frame>Through study completion, minimum 7 days</time_frame>
    <description>Investigators will calculate preperative Activity Counts per day as a baseline then being compared to postoperative Activity Counts per day until one day when both Counts is equal. Length of functional rehabilitation defines that duration from surgical day to the day when both Counts is equal.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Quality of recovery</measure>
    <time_frame>Through study completion, an average of 14 days</time_frame>
    <description>The translation of the Danish version of the postoperative quality of recovery scale QoR-15D is used to evaluate the quality of care.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The quantization of fatigue</measure>
    <time_frame>Through study completion, an average of 14 days</time_frame>
    <description>The Christensen Fatigue Scale (ChrFS) will be utilized to evaluate the degree of fatigue.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The quantization of pain</measure>
    <time_frame>Through study completion, an average of 14 days</time_frame>
    <description>The numeric rating scale (NRS) ranging from 0 (no pain) to 10 (excruciating pain) is used to score postoperative pain.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The quantization of vomiting.</measure>
    <time_frame>Through study completion, an average of 14 days</time_frame>
    <description>The numeric rating scale (NRS) ranging from 0 (nothing) to 10 (worest) is used to score postoperative vomiting.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The quantization of nausea.</measure>
    <time_frame>Through study completion, an average of 14 days</time_frame>
    <description>The numeric rating scale (NRS) ranging from 0 (nothing) to 10 (worest) is used to score postoperative nausea.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The quantization of Activity Counts</measure>
    <time_frame>Through study completion, an average of 14 days</time_frame>
    <description>Investigators will use Electric Devices to record Activity Counts per day. Activity counts will be classified as sedentary behavior (SB) &lt; 1303 counts/min (cpm), low intensity physical activity (LIPA) 1303 cpm - &lt; 2588 cpm, and moderate to vigorous physical activity (MVPA) ≧2588 cpm.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Length of sleep time</measure>
    <time_frame>Through study completion, an average of 14 days</time_frame>
    <description>Investigators will use devices to record the specific sleep time for patients.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The quantization of morbidity</measure>
    <time_frame>up to 30 days</time_frame>
    <description>The Clavien-Dindo Classification (CDC) is applied as a standard to grade the morbidity in 30 days after surgery.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The quantization of mortality</measure>
    <time_frame>up to 30 days</time_frame>
    <description>Investigators will investigate whether patients will experience unexpected death in 30 days after surgery</description>
  </secondary_outcome>
  <number_of_groups>1</number_of_groups>
  <enrollment type="Actual">32</enrollment>
  <condition>Lung Neoplasms</condition>
  <condition>Rehabilitation</condition>
  <condition>Exercise</condition>
  <condition>Pain, Postoperative</condition>
  <condition>Post Discharge</condition>
  <arm_group>
    <arm_group_label>Pilot group</arm_group_label>
    <description>As a pilot Group for observating variable rehabilitation under individual baselines.</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Actiwatch 2 (Philips Respironics, Murrysville, USA)</intervention_name>
    <description>Actiwatch 2 is an unobtrusive, waterproof, light sensor and wrist-worn device (weight 16.0g, size 4.3 cm* 2.3 cm* 1.0 cm), containing a tri-axial accelerometer able to records a digitally integrated measure of gross motor activity (a piezoelectric sensor to detect vertical accelerations at the wrist between 0.5 and 2.0 g with a frequency response range between 0.35-7.5 Hz). Activity counts from the device reflect the peak acceleration detected over each epoch and are used in determining sleep and wake intervals, which can be used to rest-activity patterns, quality of physical activity and sleep for 15-60 seconds/ epoch, 24 hours/ day, 2 weeks.</description>
    <arm_group_label>Pilot group</arm_group_label>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        Patients who will be submitted to video-assisted thoracoscopic surgery lobectomy.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  VATS-L&#xD;
&#xD;
          -  Speaks and understands Danish or English.&#xD;
&#xD;
          -  Informed consent obtained&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Co-VATS-L.&#xD;
&#xD;
          -  on the wheelchair.&#xD;
&#xD;
          -  Living in nurse home.&#xD;
&#xD;
          -  Using rollator to assist to walk.&#xD;
&#xD;
          -  Unwilling to place the Actiwatch 2 or execute PPE.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Lin Huang, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Rigshospitalet, Denmark</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Henrik Kehlet, Professor, MD, DMSc</last_name>
    <role>Study Director</role>
    <affiliation>Rigshospitalet, Denmark</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Rene H Petersen, Professor, MD, PhD</last_name>
    <role>Study Chair</role>
    <affiliation>Rigshospitalet, Denmark</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Rigshospitalet</name>
      <address>
        <city>Copenhagen</city>
        <country>Denmark</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Denmark</country>
  </location_countries>
  <reference>
    <citation>Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12. Erratum In: CA Cancer J Clin. 2020 Jul;70(4):313.</citation>
    <PMID>30207593</PMID>
  </reference>
  <reference>
    <citation>Bendixen M, Jorgensen OD, Kronborg C, Andersen C, Licht PB. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol. 2016 Jun;17(6):836-844. doi: 10.1016/S1470-2045(16)00173-X. Epub 2016 May 6.</citation>
    <PMID>27160473</PMID>
  </reference>
  <reference>
    <citation>Yang CJ, Kumar A, Deng JZ, Raman V, Lui NS, D'Amico TA, Berry MF. A National Analysis of Short-term Outcomes and Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Clinical Stage II Non-Small-Cell Lung Cancer. Ann Surg. 2021 Mar 1;273(3):595-605. doi: 10.1097/SLA.0000000000003231.</citation>
    <PMID>30946089</PMID>
  </reference>
  <reference>
    <citation>Marijic P, Walter J, Schneider C, Schwarzkopf L. Cost and survival of video-assisted thoracoscopic lobectomy versus open lobectomy in lung cancer patients: a propensity score-matched study. Eur J Cardiothorac Surg. 2020 Jan 1;57(1):92-99. doi: 10.1093/ejcts/ezz157.</citation>
    <PMID>31157367</PMID>
  </reference>
  <reference>
    <citation>Iwata H, Shirahashi K, Yamamoto H, Marui T, Matsumoto S, Mizuno Y, Matsumoto M, Mitta S, Miyamoto Y, Komuro H. Propensity score-matching analysis of hybrid video-assisted thoracoscopic surgery and thoracoscopic lobectomy for clinical stage I lung cancerdagger. Eur J Cardiothorac Surg. 2016 Apr;49(4):1063-7. doi: 10.1093/ejcts/ezv296. Epub 2015 Aug 30.</citation>
    <PMID>26324682</PMID>
  </reference>
  <reference>
    <citation>Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth. 1997 May;78(5):606-17. doi: 10.1093/bja/78.5.606.</citation>
    <PMID>9175983</PMID>
  </reference>
  <reference>
    <citation>Batchelor TJP, Rasburn NJ, Abdelnour-Berchtold E, Brunelli A, Cerfolio RJ, Gonzalez M, Ljungqvist O, Petersen RH, Popescu WM, Slinger PD, Naidu B. Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS(R)) Society and the European Society of Thoracic Surgeons (ESTS). Eur J Cardiothorac Surg. 2019 Jan 1;55(1):91-115. doi: 10.1093/ejcts/ezy301.</citation>
    <PMID>30304509</PMID>
  </reference>
  <reference>
    <citation>Kehlet H. Enhanced postoperative recovery: good from afar, but far from good? Anaesthesia. 2020 Jan;75 Suppl 1:e54-e61. doi: 10.1111/anae.14860.</citation>
    <PMID>31903577</PMID>
  </reference>
  <reference>
    <citation>Wang KY, Chang NW, Wu TH, Hsu CC, Lee YH, Lee SC. Post-discharge health care needs of patients after lung cancer resection. J Clin Nurs. 2010 Sep;19(17-18):2471-80. doi: 10.1111/j.1365-2702.2010.03298.x.</citation>
    <PMID>20920075</PMID>
  </reference>
  <reference>
    <citation>Bartels K, Mayes LM, Dingmann C, Bullard KJ, Hopfer CJ, Binswanger IA. Opioid Use and Storage Patterns by Patients after Hospital Discharge following Surgery. PLoS One. 2016 Jan 29;11(1):e0147972. doi: 10.1371/journal.pone.0147972. eCollection 2016.</citation>
    <PMID>26824844</PMID>
  </reference>
  <reference>
    <citation>Bisgaard T, Klarskov B, Rosenberg J, Kehlet H. Factors determining convalescence after uncomplicated laparoscopic cholecystectomy. Arch Surg. 2001 Aug;136(8):917-21. doi: 10.1001/archsurg.136.8.917.</citation>
    <PMID>11485527</PMID>
  </reference>
  <reference>
    <citation>Luna IE, Kehlet H, Wede HR, Hoevsgaard SJ, Aasvang EK. Objectively measured early physical activity after total hip or knee arthroplasty. J Clin Monit Comput. 2019 Jun;33(3):509-522. doi: 10.1007/s10877-018-0185-5. Epub 2018 Jul 23.</citation>
    <PMID>30039461</PMID>
  </reference>
  <reference>
    <citation>Aasvang EK, Luna IE, Kehlet H. Challenges in postdischarge function and recovery: the case of fast-track hip and knee arthroplasty. Br J Anaesth. 2015 Dec;115(6):861-6. doi: 10.1093/bja/aev257. Epub 2015 Jul 25.</citation>
    <PMID>26209853</PMID>
  </reference>
  <reference>
    <citation>Timmerman JGJ, Dekker-van Weering MGHM, Wouters MWJMM, Stuiver MMM, de Kanter WW, Vollenbroek-Hutten MMRM. Physical behavior and associations with health outcomes in operable NSCLC patients: A prospective study. Lung Cancer. 2018 May;119:91-98. doi: 10.1016/j.lungcan.2018.03.006. Epub 2018 Mar 9.</citation>
    <PMID>29656759</PMID>
  </reference>
  <reference>
    <citation>Wolvers MDJ, Bussmann JBJ, Bruggeman-Everts FZ, Boerema ST, van de Schoot R, Vollenbroek-Hutten MMR. Physical Behavior Profiles in Chronic Cancer-Related Fatigue. Int J Behav Med. 2018 Feb;25(1):30-37. doi: 10.1007/s12529-017-9670-3.</citation>
    <PMID>28699090</PMID>
  </reference>
  <verification_date>August 2021</verification_date>
  <study_first_submitted>July 31, 2020</study_first_submitted>
  <study_first_submitted_qc>August 4, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">August 6, 2020</study_first_posted>
  <last_update_submitted>August 13, 2021</last_update_submitted>
  <last_update_submitted_qc>August 13, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">August 16, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Rigshospitalet, Denmark</investigator_affiliation>
    <investigator_full_name>Lin Huang</investigator_full_name>
    <investigator_title>Medical Doctor, Research fellow, PhD student</investigator_title>
  </responsible_party>
  <keyword>Functional recovery</keyword>
  <keyword>Enhanced recovery after surgery</keyword>
  <keyword>Video-assisted thoracoscopic surgery</keyword>
  <keyword>Lobectomy</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Lung Neoplasms</mesh_term>
    <mesh_term>Pain, Postoperative</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04502654
org study id: H-20041489
nct id: NCT04502654
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
The main aim of this research is to compare the functional recovery after discharge with the
      preoperative physical activity as a hypothesis generating study.
observational model: Cohort
time perspective: Prospective
measure: Length of functional rehabilitation
time frame: Through study completion, minimum 7 days
description: Investigators will calculate preperative Activity Counts per day as a baseline then being compared to postoperative Activity Counts per day until one day when both Counts is equal. Length of functional rehabilitation defines that duration from surgical day to the day when both Counts is equal.
measure: Quality of recovery
time frame: Through study completion, an average of 14 days
description: The translation of the Danish version of the postoperative quality of recovery scale QoR-15D is used to evaluate the quality of care.
measure: The quantization of fatigue
time frame: Through study completion, an average of 14 days
description: The Christensen Fatigue Scale (ChrFS) will be utilized to evaluate the degree of fatigue.
measure: The quantization of pain
time frame: Through study completion, an average of 14 days
description: The numeric rating scale (NRS) ranging from 0 (no pain) to 10 (excruciating pain) is used to score postoperative pain.
measure: The quantization of vomiting.
time frame: Through study completion, an average of 14 days
description: The numeric rating scale (NRS) ranging from 0 (nothing) to 10 (worest) is used to score postoperative vomiting.
measure: The quantization of nausea.
time frame: Through study completion, an average of 14 days
description: The numeric rating scale (NRS) ranging from 0 (nothing) to 10 (worest) is used to score postoperative nausea.
measure: The quantization of Activity Counts
time frame: Through study completion, an average of 14 days
description: Investigators will use Electric Devices to record Activity Counts per day. Activity counts will be classified as sedentary behavior (SB) < 1303 counts/min (cpm), low intensity physical activity (LIPA) 1303 cpm - < 2588 cpm, and moderate to vigorous physical activity (MVPA) ≧2588 cpm.
measure: Length of sleep time
time frame: Through study completion, an average of 14 days
description: Investigators will use devices to record the specific sleep time for patients.
measure: The quantization of morbidity
time frame: up to 30 days
description: The Clavien-Dindo Classification (CDC) is applied as a standard to grade the morbidity in 30 days after surgery.
measure: The quantization of mortality
time frame: up to 30 days
description: Investigators will investigate whether patients will experience unexpected death in 30 days after surgery
arm group label: Pilot group
description: As a pilot Group for observating variable rehabilitation under individual baselines.
intervention type: Device
intervention name: Actiwatch 2 (Philips Respironics, Murrysville, USA)
description: Actiwatch 2 is an unobtrusive, waterproof, light sensor and wrist-worn device (weight 16.0g, size 4.3 cm* 2.3 cm* 1.0 cm), containing a tri-axial accelerometer able to records a digitally integrated measure of gross motor activity (a piezoelectric sensor to detect vertical accelerations at the wrist between 0.5 and 2.0 g with a frequency response range between 0.35-7.5 Hz). Activity counts from the device reflect the peak acceleration detected over each epoch and are used in determining sleep and wake intervals, which can be used to rest-activity patterns, quality of physical activity and sleep for 15-60 seconds/ epoch, 24 hours/ day, 2 weeks.
arm group label: Pilot group
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Lin Huang, MD
role: Principal Investigator
affiliation: Rigshospitalet, Denmark
last name: Henrik Kehlet, Professor, MD, DMSc
role: Study Director
affiliation: Rigshospitalet, Denmark
last name: Rene H Petersen, Professor, MD, PhD
role: Study Chair
affiliation: Rigshospitalet, Denmark
facility: 
country: Denmark
citation: Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12. Erratum In: CA Cancer J Clin. 2020 Jul;70(4):313.
PMID: 30207593
citation: Bendixen M, Jorgensen OD, Kronborg C, Andersen C, Licht PB. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol. 2016 Jun;17(6):836-844. doi: 10.1016/S1470-2045(16)00173-X. Epub 2016 May 6.
PMID: 27160473
citation: Yang CJ, Kumar A, Deng JZ, Raman V, Lui NS, D'Amico TA, Berry MF. A National Analysis of Short-term Outcomes and Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Clinical Stage II Non-Small-Cell Lung Cancer. Ann Surg. 2021 Mar 1;273(3):595-605. doi: 10.1097/SLA.0000000000003231.
PMID: 30946089
citation: Marijic P, Walter J, Schneider C, Schwarzkopf L. Cost and survival of video-assisted thoracoscopic lobectomy versus open lobectomy in lung cancer patients: a propensity score-matched study. Eur J Cardiothorac Surg. 2020 Jan 1;57(1):92-99. doi: 10.1093/ejcts/ezz157.
PMID: 31157367
citation: Iwata H, Shirahashi K, Yamamoto H, Marui T, Matsumoto S, Mizuno Y, Matsumoto M, Mitta S, Miyamoto Y, Komuro H. Propensity score-matching analysis of hybrid video-assisted thoracoscopic surgery and thoracoscopic lobectomy for clinical stage I lung cancerdagger. Eur J Cardiothorac Surg. 2016 Apr;49(4):1063-7. doi: 10.1093/ejcts/ezv296. Epub 2015 Aug 30.
PMID: 26324682
citation: Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth. 1997 May;78(5):606-17. doi: 10.1093/bja/78.5.606.
PMID: 9175983
citation: Batchelor TJP, Rasburn NJ, Abdelnour-Berchtold E, Brunelli A, Cerfolio RJ, Gonzalez M, Ljungqvist O, Petersen RH, Popescu WM, Slinger PD, Naidu B. Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS(R)) Society and the European Society of Thoracic Surgeons (ESTS). Eur J Cardiothorac Surg. 2019 Jan 1;55(1):91-115. doi: 10.1093/ejcts/ezy301.
PMID: 30304509
citation: Kehlet H. Enhanced postoperative recovery: good from afar, but far from good? Anaesthesia. 2020 Jan;75 Suppl 1:e54-e61. doi: 10.1111/anae.14860.
PMID: 31903577
citation: Wang KY, Chang NW, Wu TH, Hsu CC, Lee YH, Lee SC. Post-discharge health care needs of patients after lung cancer resection. J Clin Nurs. 2010 Sep;19(17-18):2471-80. doi: 10.1111/j.1365-2702.2010.03298.x.
PMID: 20920075
citation: Bartels K, Mayes LM, Dingmann C, Bullard KJ, Hopfer CJ, Binswanger IA. Opioid Use and Storage Patterns by Patients after Hospital Discharge following Surgery. PLoS One. 2016 Jan 29;11(1):e0147972. doi: 10.1371/journal.pone.0147972. eCollection 2016.
PMID: 26824844
citation: Bisgaard T, Klarskov B, Rosenberg J, Kehlet H. Factors determining convalescence after uncomplicated laparoscopic cholecystectomy. Arch Surg. 2001 Aug;136(8):917-21. doi: 10.1001/archsurg.136.8.917.
PMID: 11485527
citation: Luna IE, Kehlet H, Wede HR, Hoevsgaard SJ, Aasvang EK. Objectively measured early physical activity after total hip or knee arthroplasty. J Clin Monit Comput. 2019 Jun;33(3):509-522. doi: 10.1007/s10877-018-0185-5. Epub 2018 Jul 23.
PMID: 30039461
citation: Aasvang EK, Luna IE, Kehlet H. Challenges in postdischarge function and recovery: the case of fast-track hip and knee arthroplasty. Br J Anaesth. 2015 Dec;115(6):861-6. doi: 10.1093/bja/aev257. Epub 2015 Jul 25.
PMID: 26209853
citation: Timmerman JGJ, Dekker-van Weering MGHM, Wouters MWJMM, Stuiver MMM, de Kanter WW, Vollenbroek-Hutten MMRM. Physical behavior and associations with health outcomes in operable NSCLC patients: A prospective study. Lung Cancer. 2018 May;119:91-98. doi: 10.1016/j.lungcan.2018.03.006. Epub 2018 Mar 9.
PMID: 29656759
citation: Wolvers MDJ, Bussmann JBJ, Bruggeman-Everts FZ, Boerema ST, van de Schoot R, Vollenbroek-Hutten MMR. Physical Behavior Profiles in Chronic Cancer-Related Fatigue. Int J Behav Med. 2018 Feb;25(1):30-37. doi: 10.1007/s12529-017-9670-3.
PMID: 28699090
responsible party type: Principal Investigator
investigator affiliation: Rigshospitalet, Denmark
investigator full name: Lin Huang
investigator title: Medical Doctor, Research fellow, PhD student
mesh term: Lung Neoplasms
mesh term: Pain, Postoperative