<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04467619</url>
  </required_header>
  <id_info>
    <org_study_id>20200625</org_study_id>
    <nct_id>NCT04467619</nct_id>
  </id_info>
  <brief_title>Illusory Movements in Patients With Burns</brief_title>
  <acronym>Immobile</acronym>
  <official_title>Influence of Illusory Movements on Metabolism in Patients With Large Burns</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Charles University, Czech Republic</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Charles University, Czech Republic</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Background. Large burns are the cause of extensive skeletal muscle devastation. The&#xD;
      possibilities of rehabilitation of such patients are very limited, which contributes to the&#xD;
      risk of metabolic failure and long-term musculoskeletal disorders. Illusory movements are a&#xD;
      relatively new method of physiotherapy, which through functional proprioceptive stimulation&#xD;
      enables the integration and networking of muscle units and has a neurotrophic effect on the&#xD;
      cerebral cortex. In our pilot study, we demonstrated that illusory movements significantly&#xD;
      increased basal energy expenditure in extensively burned patients in a catabolic state and&#xD;
      with healing impairment in the later stage of burn disease. However, the metabolic effects of&#xD;
      illusory movements have not yet been studied.&#xD;
&#xD;
      Tested hypotheses. 1. The use of illusory movements is suitable for the rehabilitation of&#xD;
      patients with burns on 20% or more of the total body surface area (TBSA) in the early phase&#xD;
      of the burn disease. 2. The use of illusory movements in these patients attenuates the extent&#xD;
      of muscle catabolism.&#xD;
&#xD;
      Method. Pragmatic crossover study. Twenty patients with burns on 20% or more of the body&#xD;
      surface area will be divided into two groups. They will be rehabilitated early or delayed by&#xD;
      illusory movements for 14 days. Among other things, the following metabolic parameters will&#xD;
      be monitored: nitrogen balance, basal and resting energy expenditure (BMR, REE), insulin&#xD;
      resistance (IR), myokinins levels, muscle mitochondrial function and their morphology, and&#xD;
      ultrasound cross-sectional diameter of the rectus femoris muscle. The control group will&#xD;
      consist of ten healthy volunteers, in whom resting energy expenditure before and after using&#xD;
      illusory movements exercise will be measured.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The goal of this project is to find out whether illusory movements are suitable for patients&#xD;
      in the early phase of burn disease, and how they influence patients' metabolism.&#xD;
&#xD;
      We are going to test these hypotheses:&#xD;
&#xD;
        -  The use of illusory movements is suitable for patients with burns of 20 % TBSA and more&#xD;
           in the early acute phase of the burn disease.&#xD;
&#xD;
        -  The use of illusory movements reduces the extent of muscle catabolism in patients with&#xD;
           large burns.&#xD;
&#xD;
      Way of solution This is a pragmatic cross-over study in patients with burns of 20 % TBSA or&#xD;
      more in the early acute phase of the burn disease, who are expected to be hospitalized for 35&#xD;
      days or more. Patients meeting the inclusion criteria will be divided into two groups, A (n =&#xD;
      10) and B (n = 10). Group C will consist of healthy volunteers (n = 10).&#xD;
&#xD;
      The study will start after patient's basic cardiopulmonary stabilization, which usually&#xD;
      corresponds to days 3-5 after the injury.&#xD;
&#xD;
      Group A: Early illusory movements Phase 1: A patient enrolled in group A will have standard&#xD;
      rehabilitation according to the instructions of the attending surgeon and performed by an&#xD;
      independent physiotherapist from the start of the study (Day 1), and also FPS performed by a&#xD;
      study nurse will take place for 30 minutes twice a day, 2 hours or more after the end of&#xD;
      standard rehabilitation, for 14 days (Day 15).&#xD;
&#xD;
      Phase 2: From Day 16 onwards, the patient will undergo standard rehabilitation only according&#xD;
      to the instructions of the attending surgeon and performed by an independent physiotherapist&#xD;
      for 14 days (Day 30).&#xD;
&#xD;
      Group B: Deferred illusory movements Phase 1: A patient enrolled in group B will have&#xD;
      standard rehabilitation according to the instructions of the attending surgeon and performed&#xD;
      by an independent physiotherapist, from the start of the study (Day 1) for 14 days (Day 15).&#xD;
&#xD;
      Phase 2: Then, from Day 16 onwards, in addition to standard physiotherapy, FPS performed by a&#xD;
      study nurse will take place for 30 minutes twice a day, 2 hours or more after the end of&#xD;
      standard rehabilitation, for 14 days (Day 30).&#xD;
&#xD;
      Group C: Illusory movements in healthy individuals This group will consist of 10 healthy&#xD;
      volunteers in whom REE will be measured before and after 30 minutes of FPS.&#xD;
&#xD;
      c) Medical, social and economic rationale of this study Large burns are often the cause of&#xD;
      neuromyopathy and disability of the injured [30]. Hypercatabolism and enormous muscle loss&#xD;
      increase the morbidity and mortality of patients, prolong treatment and greatly increase the&#xD;
      overall cost of medical care [31]. Early rehabilitation using illusory movements could reduce&#xD;
      the extent of muscle devastation in otherwise immobile patients and improve the effect of&#xD;
      standard rehabilitation by maintaining functional brain maps. This should lead to an earlier&#xD;
      return of the injured to their normal activities a improve quality of life.&#xD;
&#xD;
      In addition, if the positive effects of illusory movements are proved, there are many&#xD;
      critically ill patients outside the burns who could benefit from this form of physiotherapy.&#xD;
&#xD;
      d) Methodology Nutrition support will be provided in accordance with European Society of&#xD;
      Parenteral and Enteral Nutrition recommendations.&#xD;
&#xD;
      During the study, the following parameters will be measured, and the following examinations&#xD;
      will be performed in addition to standard biochemical, haematological and imaging&#xD;
      examinations of Group A and B:&#xD;
&#xD;
      Daily:&#xD;
&#xD;
        -  Nitrogen balance;&#xD;
&#xD;
        -  Resting Energy Expenditure using indirect calorimetry;&#xD;
&#xD;
      On Days 1, 15 and 30:&#xD;
&#xD;
        -  Patient weight;&#xD;
&#xD;
        -  APACHE II score;&#xD;
&#xD;
        -  Muscle biopsy (from m. vastus lateralis);&#xD;
&#xD;
        -  BMR;&#xD;
&#xD;
        -  Glucose disposal using a hyperinsulinaemic euglycaemic clamp;&#xD;
&#xD;
        -  Degree of insulin resistance according to Homeostasis Model Assessment;&#xD;
&#xD;
        -  Muscle mitochondrial respiratory capacity and coupling with the Oxygraph-2K;&#xD;
&#xD;
        -  Mitochondrial mass determination and dynamics in myocytes with MitoTracker® ;&#xD;
&#xD;
        -  Plasmatic levels of myokinins ;&#xD;
&#xD;
        -  Ultrasound measurement of the rectus femoris diameter measured by an independent&#xD;
           sonographer.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Active, not recruiting</overall_status>
  <start_date type="Actual">June 26, 2020</start_date>
  <completion_date type="Anticipated">December 31, 2023</completion_date>
  <primary_completion_date type="Anticipated">November 30, 2023</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Crossover Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Investigator)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Energy expenditure</measure>
    <time_frame>2 years</time_frame>
    <description>The use of illusory movements changes energy expenditure in patients with large burns.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Anticatabolic effect</measure>
    <time_frame>2 years</time_frame>
    <description>The use of illusory movements changes the extent of muscle catabolism in patients with large burns.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Insulin resistance</measure>
    <time_frame>2 years</time_frame>
    <description>The use of illusory movements changes the extent of insulin resistance in patients with large burns.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Mitochondrial functions</measure>
    <time_frame>2 years</time_frame>
    <description>The use of illusory movements changes mitochondrial functions of skeletal muscle in patients with large burns.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">12</enrollment>
  <condition>Catabolic State</condition>
  <condition>Burns</condition>
  <condition>Illusions, Kinesthetic</condition>
  <arm_group>
    <arm_group_label>Early Illusory Movements</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Phase 1: A patient enrolled in group A will have standard rehabilitation according to the instructions of the attending surgeon and performed by an independent physiotherapist from the start of the study (Day 1), and also FPS performed by a study nurse will take place for 30 minutes twice a day, 2 hours or more after the end of standard rehabilitation, for 14 days (Day 15).&#xD;
Phase 2: From Day 16 onwards, the patient will undergo standard rehabilitation only according to the instructions of the attending surgeon and performed by an independent physiotherapist for 14 days (Day 30).</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Deferred Illusory Movements</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Phase 1: A patient enrolled in group B will have standard rehabilitation according to the instructions of the attending surgeon and performed by an independent physiotherapist, from the start of the study (Day 1) for 14 days (Day 15).&#xD;
Phase 2: Then, from Day 16 onwards, in addition to standard physiotherapy, FPS performed by a study nurse will take place for 30 minutes twice a day, 2 hours or more after the end of standard rehabilitation, for 14 days (Day 30).</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Functional Proprioceptive Stimulation</intervention_name>
    <description>Functional Proprioceptive Stimulations (FPS) are applied on the musculo-tendinous junction. FPS mechanically stimulate the muscle spindles, mimicking the sensory signals - Ia fibers of functional movements. This neurosensory trick activates related sensory-motor areas allowing patients to feel natural movements. Because sensory &amp; motor systems are interdependent, the central nervous system then reacts by initiating corresponding movements.</description>
    <arm_group_label>Deferred Illusory Movements</arm_group_label>
    <arm_group_label>Early Illusory Movements</arm_group_label>
    <other_name>Illusory Movements</other_name>
    <other_name>Kinesthetic Illusions</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Age 18 and older;&#xD;
&#xD;
          -  Consent to be included in the study;&#xD;
&#xD;
          -  Burns II. - III. grade on 20 % TBSA and more;&#xD;
&#xD;
          -  Admission within 72 hours of the accident;&#xD;
&#xD;
          -  Expected hospital stay of 35 days or more.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Age &lt;18 years;&#xD;
&#xD;
          -  Refusal of the study in any point;&#xD;
&#xD;
          -  Unlikely patient survival (Revised Baux Index&gt; 120);&#xD;
&#xD;
          -  Known primary neuromuscular diseases or spinal cord lesions;&#xD;
&#xD;
          -  Limb amputation before or during the study;&#xD;
&#xD;
          -  Bed rest before admission;&#xD;
&#xD;
          -  Pregnancy;&#xD;
&#xD;
          -  External fixator or surface metal implant on the limbs;&#xD;
&#xD;
          -  Known malignancy or history of malignancy treatment in the last 5 years;&#xD;
&#xD;
          -  History of HIV or AIDS;&#xD;
&#xD;
          -  Concomitant treatment with systemic corticosteroids;&#xD;
&#xD;
          -  Pacemaker, implanted defibrillator, or another bio-electronic device;&#xD;
&#xD;
          -  Patient in prison.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>University Hospital Kralovske Vinohrady</name>
      <address>
        <city>Prague</city>
        <zip>10034</zip>
        <country>Czechia</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Czechia</country>
  </location_countries>
  <reference>
    <citation>Roll R, Kavounoudias A, Albert F, Legre R, Gay A, Fabre B, Roll JP. Illusory movements prevent cortical disruption caused by immobilization. Neuroimage. 2012 Aug 1;62(1):510-9. doi: 10.1016/j.neuroimage.2012.05.016. Epub 2012 May 12.</citation>
    <PMID>22584228</PMID>
  </reference>
  <reference>
    <citation>Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers. 2020 Feb 13;6(1):11. doi: 10.1038/s41572-020-0145-5.</citation>
    <PMID>32054846</PMID>
  </reference>
  <reference>
    <citation>Waldauf P, Jiroutkova K, Krajcova A, Puthucheary Z, Duska F. Effects of Rehabilitation Interventions on Clinical Outcomes in Critically Ill Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Med. 2020 Jul;48(7):1055-1065. doi: 10.1097/CCM.0000000000004382.</citation>
    <PMID>32345834</PMID>
  </reference>
  <verification_date>August 2023</verification_date>
  <study_first_submitted>July 3, 2020</study_first_submitted>
  <study_first_submitted_qc>July 8, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 13, 2020</study_first_posted>
  <last_update_submitted>August 29, 2023</last_update_submitted>
  <last_update_submitted_qc>August 29, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">August 30, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Charles University, Czech Republic</investigator_affiliation>
    <investigator_full_name>Bohumil Bakalar MD</investigator_full_name>
    <investigator_title>The Head of ITU, Prague Burn Center, 3rd Medical School, Prague</investigator_title>
  </responsible_party>
  <keyword>Functional Proprioceptive Stimulation</keyword>
  <keyword>Illusory Movements</keyword>
  <keyword>Physiotherapy</keyword>
  <keyword>Large Burns</keyword>
  <keyword>The Critically Ill</keyword>
  <keyword>Catabolism</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Illusions</mesh_term>
    <mesh_term>Burns</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04467619
org study id: 20200625
nct id: NCT04467619
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Background. Large burns are the cause of extensive skeletal muscle devastation. The
      possibilities of rehabilitation of such patients are very limited, which contributes to the
      risk of metabolic failure and long-term musculoskeletal disorders. Illusory movements are a
      relatively new method of physiotherapy, which through functional proprioceptive stimulation
      enables the integration and networking of muscle units and has a neurotrophic effect on the
      cerebral cortex. In our pilot study, we demonstrated that illusory movements significantly
      increased basal energy expenditure in extensively burned patients in a catabolic state and
      with healing impairment in the later stage of burn disease. However, the metabolic effects of
      illusory movements have not yet been studied.

      Tested hypotheses. 1. The use of illusory movements is suitable for the rehabilitation of
      patients with burns on 20% or more of the total body surface area (TBSA) in the early phase
      of the burn disease. 2. The use of illusory movements in these patients attenuates the extent
      of muscle catabolism.

      Method. Pragmatic crossover study. Twenty patients with burns on 20% or more of the body
      surface area will be divided into two groups. They will be rehabilitated early or delayed by
      illusory movements for 14 days. Among other things, the following metabolic parameters will
      be monitored: nitrogen balance, basal and resting energy expenditure (BMR, REE), insulin
      resistance (IR), myokinins levels, muscle mitochondrial function and their morphology, and
      ultrasound cross-sectional diameter of the rectus femoris muscle. The control group will
      consist of ten healthy volunteers, in whom resting energy expenditure before and after using
      illusory movements exercise will be measured.
The goal of this project is to find out whether illusory movements are suitable for patients
      in the early phase of burn disease, and how they influence patients' metabolism.

      We are going to test these hypotheses:

        -  The use of illusory movements is suitable for patients with burns of 20 % TBSA and more
           in the early acute phase of the burn disease.

        -  The use of illusory movements reduces the extent of muscle catabolism in patients with
           large burns.

      Way of solution This is a pragmatic cross-over study in patients with burns of 20 % TBSA or
      more in the early acute phase of the burn disease, who are expected to be hospitalized for 35
      days or more. Patients meeting the inclusion criteria will be divided into two groups, A (n =
      10) and B (n = 10). Group C will consist of healthy volunteers (n = 10).

      The study will start after patient's basic cardiopulmonary stabilization, which usually
      corresponds to days 3-5 after the injury.

      Group A: Early illusory movements Phase 1: A patient enrolled in group A will have standard
      rehabilitation according to the instructions of the attending surgeon and performed by an
      independent physiotherapist from the start of the study (Day 1), and also FPS performed by a
      study nurse will take place for 30 minutes twice a day, 2 hours or more after the end of
      standard rehabilitation, for 14 days (Day 15).

      Phase 2: From Day 16 onwards, the patient will undergo standard rehabilitation only according
      to the instructions of the attending surgeon and performed by an independent physiotherapist
      for 14 days (Day 30).

      Group B: Deferred illusory movements Phase 1: A patient enrolled in group B will have
      standard rehabilitation according to the instructions of the attending surgeon and performed
      by an independent physiotherapist, from the start of the study (Day 1) for 14 days (Day 15).

      Phase 2: Then, from Day 16 onwards, in addition to standard physiotherapy, FPS performed by a
      study nurse will take place for 30 minutes twice a day, 2 hours or more after the end of
      standard rehabilitation, for 14 days (Day 30).

      Group C: Illusory movements in healthy individuals This group will consist of 10 healthy
      volunteers in whom REE will be measured before and after 30 minutes of FPS.

      c) Medical, social and economic rationale of this study Large burns are often the cause of
      neuromyopathy and disability of the injured [30]. Hypercatabolism and enormous muscle loss
      increase the morbidity and mortality of patients, prolong treatment and greatly increase the
      overall cost of medical care [31]. Early rehabilitation using illusory movements could reduce
      the extent of muscle devastation in otherwise immobile patients and improve the effect of
      standard rehabilitation by maintaining functional brain maps. This should lead to an earlier
      return of the injured to their normal activities a improve quality of life.

      In addition, if the positive effects of illusory movements are proved, there are many
      critically ill patients outside the burns who could benefit from this form of physiotherapy.

      d) Methodology Nutrition support will be provided in accordance with European Society of
      Parenteral and Enteral Nutrition recommendations.

      During the study, the following parameters will be measured, and the following examinations
      will be performed in addition to standard biochemical, haematological and imaging
      examinations of Group A and B:

      Daily:

        -  Nitrogen balance;

        -  Resting Energy Expenditure using indirect calorimetry;

      On Days 1, 15 and 30:

        -  Patient weight;

        -  APACHE II score;

        -  Muscle biopsy (from m. vastus lateralis);

        -  BMR;

        -  Glucose disposal using a hyperinsulinaemic euglycaemic clamp;

        -  Degree of insulin resistance according to Homeostasis Model Assessment;

        -  Muscle mitochondrial respiratory capacity and coupling with the Oxygraph-2K;

        -  Mitochondrial mass determination and dynamics in myocytes with MitoTracker® ;

        -  Plasmatic levels of myokinins ;

        -  Ultrasound measurement of the rectus femoris diameter measured by an independent
           sonographer.
allocation: Randomized
intervention model: Crossover Assignment
primary purpose: Treatment
masking: Single (Investigator)
measure: Energy expenditure
time frame: 2 years
description: The use of illusory movements changes energy expenditure in patients with large burns.
measure: Anticatabolic effect
time frame: 2 years
description: The use of illusory movements changes the extent of muscle catabolism in patients with large burns.
measure: Insulin resistance
time frame: 2 years
description: The use of illusory movements changes the extent of insulin resistance in patients with large burns.
measure: Mitochondrial functions
time frame: 2 years
description: The use of illusory movements changes mitochondrial functions of skeletal muscle in patients with large burns.
arm group label: Early Illusory Movements
arm group type: Active Comparator
description: Phase 1: A patient enrolled in group A will have standard rehabilitation according to the instructions of the attending surgeon and performed by an independent physiotherapist from the start of the study (Day 1), and also FPS performed by a study nurse will take place for 30 minutes twice a day, 2 hours or more after the end of standard rehabilitation, for 14 days (Day 15).
Phase 2: From Day 16 onwards, the patient will undergo standard rehabilitation only according to the instructions of the attending surgeon and performed by an independent physiotherapist for 14 days (Day 30).
arm group label: Deferred Illusory Movements
arm group type: Active Comparator
description: Phase 1: A patient enrolled in group B will have standard rehabilitation according to the instructions of the attending surgeon and performed by an independent physiotherapist, from the start of the study (Day 1) for 14 days (Day 15).
Phase 2: Then, from Day 16 onwards, in addition to standard physiotherapy, FPS performed by a study nurse will take place for 30 minutes twice a day, 2 hours or more after the end of standard rehabilitation, for 14 days (Day 30).
intervention type: Device
intervention name: Functional Proprioceptive Stimulation
description: Functional Proprioceptive Stimulations (FPS) are applied on the musculo-tendinous junction. FPS mechanically stimulate the muscle spindles, mimicking the sensory signals - Ia fibers of functional movements. This neurosensory trick activates related sensory-motor areas allowing patients to feel natural movements. Because sensory & motor systems are interdependent, the central nervous system then reacts by initiating corresponding movements.
arm group label: Deferred Illusory Movements
arm group label: Early Illusory Movements
other name: Illusory Movements
other name: Kinesthetic Illusions
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
facility: 
country: Czechia
citation: Roll R, Kavounoudias A, Albert F, Legre R, Gay A, Fabre B, Roll JP. Illusory movements prevent cortical disruption caused by immobilization. Neuroimage. 2012 Aug 1;62(1):510-9. doi: 10.1016/j.neuroimage.2012.05.016. Epub 2012 May 12.
PMID: 22584228
citation: Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers. 2020 Feb 13;6(1):11. doi: 10.1038/s41572-020-0145-5.
PMID: 32054846
citation: Waldauf P, Jiroutkova K, Krajcova A, Puthucheary Z, Duska F. Effects of Rehabilitation Interventions on Clinical Outcomes in Critically Ill Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Med. 2020 Jul;48(7):1055-1065. doi: 10.1097/CCM.0000000000004382.
PMID: 32345834
responsible party type: Principal Investigator
investigator affiliation: Charles University, Czech Republic
investigator full name: Bohumil Bakalar MD
investigator title: The Head of ITU, Prague Burn Center, 3rd Medical School, Prague
mesh term: Illusions
mesh term: Burns