<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04457739</url>
  </required_header>
  <id_info>
    <org_study_id>2019-A00064-53</org_study_id>
    <nct_id>NCT04457739</nct_id>
  </id_info>
  <brief_title>Assessment of Preload Responsiveness in ARDS Patients During Prone Position</brief_title>
  <acronym>PR-ARDS-PP</acronym>
  <official_title>Evaluation of Tidal Volume Challenge to Detect Preload-responsiveness in Patients With Acute Respiratory Distress Syndrome (ARDS) During Prone Position</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Bicetre Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Bicetre Hospital</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Evaluation of preload responsiveness in ARDS patients during prone position is difficult and&#xD;
      only one study showed Trendelenburg manoeuvre can be used in this group of patients. This&#xD;
      study aims to investigate whether end-expiratory occlusion test, tidal volume challenge&#xD;
      (using the changes in PPV) can be used to evaluate preload responsiveness in patients with&#xD;
      ARDS ventilated with a low tidal volume and who underwent a PP session.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Acute respiratory distress syndrome (ARDS) which is a major cause of morbidity and mortality&#xD;
      in the intensive care unit, is characterized by decreased lung volume, decreased lung&#xD;
      compliance, increased pulmonary vascular resistance and pulmonary hypertension, which&#xD;
      ultimately lead to right ventricular dysfunction. Moreover, through biventricular&#xD;
      interdependence and inter-ventricular septum shift, the left ventricular filling is limited,&#xD;
      which eventually results in a decrease in stroke volume. Due to the high risk of&#xD;
      ventilation-induced lung injury, protective lung ventilation is recommended, mainly through a&#xD;
      reduction in tidal volume. However, due to the profound hypoxemia inherent to this mode of&#xD;
      ventilation, lung recruitment strategies are recommended. When the application of a&#xD;
      recruitive positive end-expiratory pressure fails to correct hypoxemia, prone positioning&#xD;
      (PP) is recommended. A randomized controlled trial (PROSEVA) reported that early application&#xD;
      of prolonged PP sessions in patients with severe ARDS significantly decreased 28- and 90-day&#xD;
      mortality. In addition to its respiratory effects (improvement in arterial oxygenation and&#xD;
      lung recruitment), PP exerts different cardiovascular effects. By increasing oxygenation and&#xD;
      recruiting lung regions, PP can reduce the right ventricular afterload. By increasing the&#xD;
      intraabdominal pressure (IAP), PP can increase the venous return and the cardiac preload.&#xD;
      This effect might depend on the level of IAP, because a high IAP might collapse the inferior&#xD;
      vena cava, especially in the case of hypovolemia. If cardiac preload increases, the resultant&#xD;
      effect on cardiac output might depend on the degree of preload responsiveness. Finally, by&#xD;
      increasing the IAP, PP can increase the left ventricular afterload. In a recent clinical&#xD;
      study, our group showed that PP increases right and left ventricular preload and decreased&#xD;
      right ventricular afterload. However, PP increased cardiac output only in patients with&#xD;
      preload responsiveness. In this study preload responsiveness was detected by an increase in&#xD;
      cardiac output &gt; 10% during a passive leg raising (PLR) test. Since PP sessions are&#xD;
      recommended to last between 16 to 18 hours per day and since patients with ARDS often have an&#xD;
      associated sepsis, hemodynamically instability may occur during PP sessions. The therapeutic&#xD;
      decision is very tricky since the administration of fluid (the main therapeutic option in&#xD;
      case of hemodynamic instability) is risky due to alteration of lung capillary membrane&#xD;
      permeability. Thus, it is important to predict the benefits of fluid administration by using&#xD;
      indices of preload responsiveness. The recommended indices of preload responsiveness are&#xD;
      pulse pressure variation (PPV), stroke volume variation (SVV) and PLR. However, PPV and SVV&#xD;
      cannot be used reliably during low tidal volume ventilation. Moreover, conventional PLR&#xD;
      cannot be performed during PP. It is thus important to develop other preload responsiveness&#xD;
      tests doable during PP. Our group proposed to perform an end-expiratory occlusion (EEO) test&#xD;
      to predict fluid responsiveness in the supine position and more recently to perform a tidal&#xD;
      volume challenge (TVC) by transiently increasing tidal volume from 6 to 8 mL/kg and observing&#xD;
      the changes in PPV.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">January 8, 2019</start_date>
  <completion_date type="Actual">December 31, 2021</completion_date>
  <primary_completion_date type="Actual">May 6, 2021</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Area under ROC curve of the change in pulse pressure variation during tidal volume challenge to detect preload responsiveness</measure>
    <time_frame>1 minute after increasing tidal volume from 6 to 8mL/kg</time_frame>
  </primary_outcome>
  <secondary_outcome>
    <measure>Area under ROC curve of the pulse pressure variation in tidal volume of 8ml/kg in continuous cardiac output during end-expiratory occlusion to detect preload dependence</measure>
    <time_frame>1 minute after tidal volume increase to 8 ml/kg</time_frame>
  </secondary_outcome>
  <enrollment type="Actual">58</enrollment>
  <condition>Acute Respiratory Distress Syndrome</condition>
  <condition>Septic Shock</condition>
  <condition>Hemodynamic Instability</condition>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Tidal volume challenge</intervention_name>
    <description>Increasing tidal volume from 6 to 8 mL/kg during 1 min</description>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>End-expiratory occlusion test</intervention_name>
    <description>Interrupting the ventilator at end-expiration for 15-30 s and assessing the resulting changes in cardiac output</description>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Trendelenburg maneuver</intervention_name>
    <description>Patients remained in prone position with a 13° upward bed angulation throughout the study and then be positioned in a declining position at -12 ° for 1 minute</description>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        Patients with severe ARDS (according to the Berlin definition) undergoing a prone position&#xD;
        session, already monitored with a transpulmonary thermodilution device and for whom the&#xD;
        evaluation of preload responsiveness is needed owing to the occurrence of hemodynamic&#xD;
        instability.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  ARDS patient&#xD;
&#xD;
          -  Prone position&#xD;
&#xD;
          -  Monitored by transpulmonary thermodilution and pulse contour analysis&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Age below 18&#xD;
&#xD;
          -  No social security&#xD;
&#xD;
          -  Refuse to participate in the study&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>Bicetre Hospital</name>
      <address>
        <city>Paris</city>
        <state>Val-de-Marne</state>
        <zip>94270</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>France</country>
  </location_countries>
  <reference>
    <citation>Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000 May 4;342(18):1334-49. doi: 10.1056/NEJM200005043421806. No abstract available.</citation>
    <PMID>10793167</PMID>
  </reference>
  <reference>
    <citation>Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, Marini JJ. Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. Intensive Care Med. 2016 May;42(5):739-749. doi: 10.1007/s00134-016-4326-3. Epub 2016 Apr 1.</citation>
    <PMID>27038480</PMID>
  </reference>
  <reference>
    <citation>Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017 Mar;43(3):304-377. doi: 10.1007/s00134-017-4683-6. Epub 2017 Jan 18.</citation>
    <PMID>28101605</PMID>
  </reference>
  <reference>
    <citation>Guerin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Baboi L, Ayzac L; PROSEVA Study Group. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013 Jun 6;368(23):2159-68. doi: 10.1056/NEJMoa1214103. Epub 2013 May 20.</citation>
    <PMID>23688302</PMID>
  </reference>
  <reference>
    <citation>Jozwiak M, Monnet X, Teboul JL. Optimizing the circulation in the prone patient. Curr Opin Crit Care. 2016 Jun;22(3):239-45. doi: 10.1097/MCC.0000000000000308.</citation>
    <PMID>27101363</PMID>
  </reference>
  <reference>
    <citation>Jozwiak M, Teboul JL, Anguel N, Persichini R, Silva S, Chemla D, Richard C, Monnet X. Beneficial hemodynamic effects of prone positioning in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2013 Dec 15;188(12):1428-33. doi: 10.1164/rccm.201303-0593OC.</citation>
    <PMID>24102072</PMID>
  </reference>
  <reference>
    <citation>Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291. Erratum In: JAMA. 2016 Jul 19;316(3):350. JAMA. 2016 Jul 19;316(3):350.</citation>
    <PMID>26903337</PMID>
  </reference>
  <reference>
    <citation>Guerin C, Beuret P, Constantin JM, Bellani G, Garcia-Olivares P, Roca O, Meertens JH, Maia PA, Becher T, Peterson J, Larsson A, Gurjar M, Hajjej Z, Kovari F, Assiri AH, Mainas E, Hasan MS, Morocho-Tutillo DR, Baboi L, Chretien JM, Francois G, Ayzac L, Chen L, Brochard L, Mercat A; investigators of the APRONET Study Group, the REVA Network, the Reseau recherche de la Societe Francaise d'Anesthesie-Reanimation (SFAR-recherche) and the ESICM Trials Group. A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study. Intensive Care Med. 2018 Jan;44(1):22-37. doi: 10.1007/s00134-017-4996-5. Epub 2017 Dec 7.</citation>
    <PMID>29218379</PMID>
  </reference>
  <reference>
    <citation>Wheeler AP, Bernard GR. Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet. 2007 May 5;369(9572):1553-1564. doi: 10.1016/S0140-6736(07)60604-7.</citation>
    <PMID>17482987</PMID>
  </reference>
  <reference>
    <citation>Chiumello D, Brochard L, Marini JJ, Slutsky AS, Mancebo J, Ranieri VM, Thompson BT, Papazian L, Schultz MJ, Amato M, Gattinoni L, Mercat A, Pesenti A, Talmor D, Vincent JL. Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Crit Care. 2017 Sep 12;21(1):240. doi: 10.1186/s13054-017-1820-0.</citation>
    <PMID>28899408</PMID>
  </reference>
  <reference>
    <citation>Roch A, Guervilly C, Papazian L. Fluid management in acute lung injury and ards. Ann Intensive Care. 2011 May 30;1(1):16. doi: 10.1186/2110-5820-1-16.</citation>
    <PMID>21906342</PMID>
  </reference>
  <reference>
    <citation>Teboul JL, Monnet X, Chemla D, Michard F. Arterial Pulse Pressure Variation with Mechanical Ventilation. Am J Respir Crit Care Med. 2019 Jan 1;199(1):22-31. doi: 10.1164/rccm.201801-0088CI.</citation>
    <PMID>30138573</PMID>
  </reference>
  <reference>
    <citation>Yonis H, Bitker L, Aublanc M, Perinel Ragey S, Riad Z, Lissonde F, Louf-Durier A, Debord S, Gobert F, Tapponnier R, Guerin C, Richard JC. Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndrome in the prone position under protective ventilation. Crit Care. 2017 Dec 5;21(1):295. doi: 10.1186/s13054-017-1881-0.</citation>
    <PMID>29208025</PMID>
  </reference>
  <reference>
    <citation>Sibbald WJ, Paterson NA, Holliday RL, Baskerville J. The Trendelenburg position: hemodynamic effects in hypotensive and normotensive patients. Crit Care Med. 1979 May;7(5):218-24.</citation>
    <PMID>467083</PMID>
  </reference>
  <reference>
    <citation>Geerts BF, van den Bergh L, Stijnen T, Aarts LP, Jansen JR. Comprehensive review: is it better to use the Trendelenburg position or passive leg raising for the initial treatment of hypovolemia? J Clin Anesth. 2012 Dec;24(8):668-74. doi: 10.1016/j.jclinane.2012.06.003.</citation>
    <PMID>23228872</PMID>
  </reference>
  <reference>
    <citation>Myatra SN, Prabu NR, Divatia JV, Monnet X, Kulkarni AP, Teboul JL. The Changes in Pulse Pressure Variation or Stroke Volume Variation After a &quot;Tidal Volume Challenge&quot; Reliably Predict Fluid Responsiveness During Low Tidal Volume Ventilation. Crit Care Med. 2017 Mar;45(3):415-421. doi: 10.1097/CCM.0000000000002183.</citation>
    <PMID>27922879</PMID>
  </reference>
  <reference>
    <citation>Monnet X, Osman D, Ridel C, Lamia B, Richard C, Teboul JL. Predicting volume responsiveness by using the end-expiratory occlusion in mechanically ventilated intensive care unit patients. Crit Care Med. 2009 Mar;37(3):951-6. doi: 10.1097/CCM.0b013e3181968fe1.</citation>
    <PMID>19237902</PMID>
  </reference>
  <verification_date>March 2022</verification_date>
  <study_first_submitted>June 30, 2020</study_first_submitted>
  <study_first_submitted_qc>June 30, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 7, 2020</study_first_posted>
  <last_update_submitted>March 1, 2022</last_update_submitted>
  <last_update_submitted_qc>March 1, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">March 2, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Bicetre Hospital</investigator_affiliation>
    <investigator_full_name>Rui Shi</investigator_full_name>
    <investigator_title>Principal Investigator</investigator_title>
  </responsible_party>
  <keyword>Hemodynamic monitoring</keyword>
  <keyword>preload responsiveness</keyword>
  <keyword>ARDS</keyword>
  <keyword>Fluid therapy</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Respiratory Distress Syndrome</mesh_term>
    <mesh_term>Respiratory Distress Syndrome, Newborn</mesh_term>
    <mesh_term>Acute Lung Injury</mesh_term>
    <mesh_term>Syndrome</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04457739
org study id: 2019-A00064-53
nct id: NCT04457739
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Evaluation of preload responsiveness in ARDS patients during prone position is difficult and
      only one study showed Trendelenburg manoeuvre can be used in this group of patients. This
      study aims to investigate whether end-expiratory occlusion test, tidal volume challenge
      (using the changes in PPV) can be used to evaluate preload responsiveness in patients with
      ARDS ventilated with a low tidal volume and who underwent a PP session.
Acute respiratory distress syndrome (ARDS) which is a major cause of morbidity and mortality
      in the intensive care unit, is characterized by decreased lung volume, decreased lung
      compliance, increased pulmonary vascular resistance and pulmonary hypertension, which
      ultimately lead to right ventricular dysfunction. Moreover, through biventricular
      interdependence and inter-ventricular septum shift, the left ventricular filling is limited,
      which eventually results in a decrease in stroke volume. Due to the high risk of
      ventilation-induced lung injury, protective lung ventilation is recommended, mainly through a
      reduction in tidal volume. However, due to the profound hypoxemia inherent to this mode of
      ventilation, lung recruitment strategies are recommended. When the application of a
      recruitive positive end-expiratory pressure fails to correct hypoxemia, prone positioning
      (PP) is recommended. A randomized controlled trial (PROSEVA) reported that early application
      of prolonged PP sessions in patients with severe ARDS significantly decreased 28- and 90-day
      mortality. In addition to its respiratory effects (improvement in arterial oxygenation and
      lung recruitment), PP exerts different cardiovascular effects. By increasing oxygenation and
      recruiting lung regions, PP can reduce the right ventricular afterload. By increasing the
      intraabdominal pressure (IAP), PP can increase the venous return and the cardiac preload.
      This effect might depend on the level of IAP, because a high IAP might collapse the inferior
      vena cava, especially in the case of hypovolemia. If cardiac preload increases, the resultant
      effect on cardiac output might depend on the degree of preload responsiveness. Finally, by
      increasing the IAP, PP can increase the left ventricular afterload. In a recent clinical
      study, our group showed that PP increases right and left ventricular preload and decreased
      right ventricular afterload. However, PP increased cardiac output only in patients with
      preload responsiveness. In this study preload responsiveness was detected by an increase in
      cardiac output > 10% during a passive leg raising (PLR) test. Since PP sessions are
      recommended to last between 16 to 18 hours per day and since patients with ARDS often have an
      associated sepsis, hemodynamically instability may occur during PP sessions. The therapeutic
      decision is very tricky since the administration of fluid (the main therapeutic option in
      case of hemodynamic instability) is risky due to alteration of lung capillary membrane
      permeability. Thus, it is important to predict the benefits of fluid administration by using
      indices of preload responsiveness. The recommended indices of preload responsiveness are
      pulse pressure variation (PPV), stroke volume variation (SVV) and PLR. However, PPV and SVV
      cannot be used reliably during low tidal volume ventilation. Moreover, conventional PLR
      cannot be performed during PP. It is thus important to develop other preload responsiveness
      tests doable during PP. Our group proposed to perform an end-expiratory occlusion (EEO) test
      to predict fluid responsiveness in the supine position and more recently to perform a tidal
      volume challenge (TVC) by transiently increasing tidal volume from 6 to 8 mL/kg and observing
      the changes in PPV.
observational model: Cohort
time perspective: Prospective
measure: Area under ROC curve of the change in pulse pressure variation during tidal volume challenge to detect preload responsiveness
time frame: 1 minute after increasing tidal volume from 6 to 8mL/kg
measure: Area under ROC curve of the pulse pressure variation in tidal volume of 8ml/kg in continuous cardiac output during end-expiratory occlusion to detect preload dependence
time frame: 1 minute after tidal volume increase to 8 ml/kg
intervention type: Other
intervention name: Tidal volume challenge
description: Increasing tidal volume from 6 to 8 mL/kg during 1 min
intervention type: Other
intervention name: End-expiratory occlusion test
description: Interrupting the ventilator at end-expiration for 15-30 s and assessing the resulting changes in cardiac output
intervention type: Other
intervention name: Trendelenburg maneuver
description: Patients remained in prone position with a 13° upward bed angulation throughout the study and then be positioned in a declining position at -12 ° for 1 minute
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
facility: 
country: France
citation: Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000 May 4;342(18):1334-49. doi: 10.1056/NEJM200005043421806. No abstract available.
PMID: 10793167
citation: Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, Marini JJ. Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. Intensive Care Med. 2016 May;42(5):739-749. doi: 10.1007/s00134-016-4326-3. Epub 2016 Apr 1.
PMID: 27038480
citation: Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, Rochwerg B, Rubenfeld GD, Angus DC, Annane D, Beale RJ, Bellinghan GJ, Bernard GR, Chiche JD, Coopersmith C, De Backer DP, French CJ, Fujishima S, Gerlach H, Hidalgo JL, Hollenberg SM, Jones AE, Karnad DR, Kleinpell RM, Koh Y, Lisboa TC, Machado FR, Marini JJ, Marshall JC, Mazuski JE, McIntyre LA, McLean AS, Mehta S, Moreno RP, Myburgh J, Navalesi P, Nishida O, Osborn TM, Perner A, Plunkett CM, Ranieri M, Schorr CA, Seckel MA, Seymour CW, Shieh L, Shukri KA, Simpson SQ, Singer M, Thompson BT, Townsend SR, Van der Poll T, Vincent JL, Wiersinga WJ, Zimmerman JL, Dellinger RP. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017 Mar;43(3):304-377. doi: 10.1007/s00134-017-4683-6. Epub 2017 Jan 18.
PMID: 28101605
citation: Guerin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, Clavel M, Chatellier D, Jaber S, Rosselli S, Mancebo J, Sirodot M, Hilbert G, Bengler C, Richecoeur J, Gainnier M, Bayle F, Bourdin G, Leray V, Girard R, Baboi L, Ayzac L; PROSEVA Study Group. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med. 2013 Jun 6;368(23):2159-68. doi: 10.1056/NEJMoa1214103. Epub 2013 May 20.
PMID: 23688302
citation: Jozwiak M, Monnet X, Teboul JL. Optimizing the circulation in the prone patient. Curr Opin Crit Care. 2016 Jun;22(3):239-45. doi: 10.1097/MCC.0000000000000308.
PMID: 27101363
citation: Jozwiak M, Teboul JL, Anguel N, Persichini R, Silva S, Chemla D, Richard C, Monnet X. Beneficial hemodynamic effects of prone positioning in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2013 Dec 15;188(12):1428-33. doi: 10.1164/rccm.201303-0593OC.
PMID: 24102072
citation: Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, Gattinoni L, van Haren F, Larsson A, McAuley DF, Ranieri M, Rubenfeld G, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016 Feb 23;315(8):788-800. doi: 10.1001/jama.2016.0291. Erratum In: JAMA. 2016 Jul 19;316(3):350. JAMA. 2016 Jul 19;316(3):350.
PMID: 26903337
citation: Guerin C, Beuret P, Constantin JM, Bellani G, Garcia-Olivares P, Roca O, Meertens JH, Maia PA, Becher T, Peterson J, Larsson A, Gurjar M, Hajjej Z, Kovari F, Assiri AH, Mainas E, Hasan MS, Morocho-Tutillo DR, Baboi L, Chretien JM, Francois G, Ayzac L, Chen L, Brochard L, Mercat A; investigators of the APRONET Study Group, the REVA Network, the Reseau recherche de la Societe Francaise d'Anesthesie-Reanimation (SFAR-recherche) and the ESICM Trials Group. A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study. Intensive Care Med. 2018 Jan;44(1):22-37. doi: 10.1007/s00134-017-4996-5. Epub 2017 Dec 7.
PMID: 29218379
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responsible party type: Principal Investigator
investigator affiliation: Bicetre Hospital
investigator full name: Rui Shi
investigator title: Principal Investigator
mesh term: Respiratory Distress Syndrome
mesh term: Respiratory Distress Syndrome, Newborn
mesh term: Acute Lung Injury
mesh term: Syndrome
sharing ipd: Undecided