<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04422184</url>
  </required_header>
  <id_info>
    <org_study_id>DHPP60</org_study_id>
    <nct_id>NCT04422184</nct_id>
  </id_info>
  <brief_title>Comparative Clinical Evaluation of Three Different Agents in Reducing Dental Hypersensitivity in Periodontal Patients</brief_title>
  <official_title>Comparative Clinical Evaluation of Three Different Technologies (Novamin, Refix and Refix-k) in Reducing Dental Hypersensitivity in Periodontal Patients</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Sao Paulo</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>University of Sao Paulo</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The present project will compare the effect of DH reduction using three different dentifrices&#xD;
      (Sensodyne Repair and Protect - NOVAMIN technology; Dentalclean Daily Regenerator - REFIX&#xD;
      technology; Dentalclean Daily Regenerator - REFIX technology + potassium citrate) in&#xD;
      periodontal patients. The evaluation will be in 6 moments: T1 and T2- immediately before and&#xD;
      after scaling and root planing (SRP) procedures; T3-after polishing sensitive areas with&#xD;
      rubbers cups and the dentifrice determined for each group of patients and T4, 5, 6- After 2,&#xD;
      4 and 8 weeks of SRP. Profissional assessments and patient perception data will be performed.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Periodontal patients may report dentinal hypersensitivity (DH) caused by root surface&#xD;
      exposure as part of disease process or as a result of periodontal treatment. Although some&#xD;
      studies evaluated DH reduction using desensitizing toothpastes, no specific chemical/physical&#xD;
      agent is reported for periodontal patients. Thus, the present project will compare the effect&#xD;
      of DH reduction using three different dentifrices (Sensodyne Repair and Protect - NOVAMIN&#xD;
      technology; Dentalclean Daily Regenerator - REFIX technology; Dentalclean Daily Regenerator -&#xD;
      REFIX technology + potassium citrate) in periodontal patients. This randomized, parallel and&#xD;
      blinded clinical trial will be divided into 3 groups (SEN GROUP: Sensodyne; REG GROUP:&#xD;
      Regenerator; REGK GROUP: Regenerator + Potassium Citrate) and evaluated at 6 moments: T1 and&#xD;
      T2- immediately before and after scaling and root planing (SRP) procedures; T3-after&#xD;
      polishing sensitive areas with rubbers cups and the dentifrice determined for each group of&#xD;
      patients and T4, 5, 6- After 2, 4 and 8 weeks of SRP. Air blast sensitivity assessments&#xD;
      (Schiff scale) and patient perception data on DH will be performed using visual analog scales&#xD;
      (VAS). The comparison between treatment groups will be done by paired T-test if normal&#xD;
      distribution is observed or Wilcoxon if non-normal distribution. The significance level&#xD;
      adopted will be 5% (p &lt;0.05).&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">July 29, 2019</start_date>
  <completion_date type="Anticipated">July 2022</completion_date>
  <primary_completion_date type="Anticipated">December 2021</primary_completion_date>
  <phase>Phase 4</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Triple (Participant, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Professional evaluation of Dentin Hypersensitivity</measure>
    <time_frame>T1- immediately before scaling and root planing procedures (SRP)</time_frame>
    <description>Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Professional evaluation of Dentin Hypersensitivity</measure>
    <time_frame>T2 - immediately after scaling and root planing procedures (SRP)</time_frame>
    <description>Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Professional evaluation of Dentin Hypersensitivity</measure>
    <time_frame>T3 - immediately after polishing sensitive areas with rubber cups and the dentifrice determined for each group of patients.</time_frame>
    <description>Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Professional evaluation of Dentin Hypersensitivity</measure>
    <time_frame>T4 - 2 weeks after SRP.</time_frame>
    <description>Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Professional evaluation of Dentin Hypersensitivity</measure>
    <time_frame>T5 - 4 weeks after SRP.</time_frame>
    <description>Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Professional evaluation of Dentin Hypersensitivity</measure>
    <time_frame>T6 - 8 weeks after SRP.</time_frame>
    <description>Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Patient's perception of DH</measure>
    <time_frame>T1- immediately before scaling and root planing procedures (SRP)</time_frame>
    <description>Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient's perception of DH</measure>
    <time_frame>T2 - immediately after scaling and root planing procedures (SRP)</time_frame>
    <description>Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient's perception of DH</measure>
    <time_frame>T3 - immediately after polishing sensitive areas with rubber cups and the dentifrice determined for each group of patients.</time_frame>
    <description>Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient's perception of DH</measure>
    <time_frame>T4 - 2 weeks after SRP.</time_frame>
    <description>Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient's perception of DH</measure>
    <time_frame>T5 - 4 weeks after SRP.</time_frame>
    <description>Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient's perception of DH</measure>
    <time_frame>T6 - 8 weeks after SRP.</time_frame>
    <description>Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.</description>
  </secondary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Anticipated">60</enrollment>
  <condition>Dentin Hypersensitivity</condition>
  <condition>Periodontal Diseases</condition>
  <arm_group>
    <arm_group_label>SEN GROUP</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Sensodyne Repair and Protect - NOVAMIN technology</description>
  </arm_group>
  <arm_group>
    <arm_group_label>REG GROUP</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Dentalclean Daily Regenerator - REFIX technology</description>
  </arm_group>
  <arm_group>
    <arm_group_label>REGK GROUP</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Dentalclean Daily Regenerator - REFIX technology + potassium citrate</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Sensodyne Repair and Protect</intervention_name>
    <description>Dentifricie with NOVAMIN technology</description>
    <arm_group_label>SEN GROUP</arm_group_label>
    <other_name>Dentifrice with desensitizing agents</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Dentalclean Daily Regenerator</intervention_name>
    <description>Dentifricie with Refix technology</description>
    <arm_group_label>REG GROUP</arm_group_label>
    <other_name>Dentifrice with desensitizing agents</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Dentalclean Daily Regenerator with potassium citrate</intervention_name>
    <description>Dentifricie with Refix technology+ potassium citrate</description>
    <arm_group_label>REGK GROUP</arm_group_label>
    <other_name>Dentifrice with desensitizing agents</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  patients diagnosed with periodontitis&#xD;
&#xD;
          -  18 to 70 years old&#xD;
&#xD;
          -  systemically healthy&#xD;
&#xD;
          -  without any allergy to the dentifrices components&#xD;
&#xD;
          -  patients who needed scaling and root planing procedures&#xD;
&#xD;
          -  patients who had at least 2 teeth with DH (incisors, canines or premolars).&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  pregnancy&#xD;
&#xD;
          -  patients in orthodontic treatment&#xD;
&#xD;
          -  patients with oral tumors, caries, fractured teeth, suspected endodontic involvement&#xD;
             or excessive mobility;&#xD;
&#xD;
          -  patients who used medication that could mask the painful sensation or who had used&#xD;
             desensitizing agents in the last 3 months.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>70 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Mariana S Ragghianti Zangrando, Prof</last_name>
    <role>Principal Investigator</role>
    <affiliation>USP</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Mariana S Ragghianti Zangrando, Prof</last_name>
    <phone>14996962250</phone>
    <email>mariana@fob.usp.br</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Giovana Favero</last_name>
    <email>giovannaffavero@hotmail.com</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Bauru School of Denstistry</name>
      <address>
        <city>Bauru</city>
        <state>SP</state>
        <zip>17012-901</zip>
        <country>Brazil</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Mariana S Ragghianti Zangrando, Prof</last_name>
      <email>mariana@fob.usp.br</email>
    </contact>
    <contact_backup>
      <last_name>Giovana Favero</last_name>
      <email>giovannaffavero@hotmail.com</email>
    </contact_backup>
  </location>
  <location_countries>
    <country>Brazil</country>
  </location_countries>
  <reference>
    <citation>West NX, Seong J, Davies M. Management of dentine hypersensitivity: efficacy of professionally and self-administered agents. J Clin Periodontol. 2015 Apr;42 Suppl 16:S256-302. doi: 10.1111/jcpe.12336.</citation>
    <PMID>25495777</PMID>
  </reference>
  <reference>
    <citation>Patil SA, Naik BD, Suma R. Evaluation of three different agents for in-office treatment of dentinal hypersensitivity: a controlled clinical study. Indian J Dent Res. 2015 Jan-Feb;26(1):38-42. doi: 10.4103/0970-9290.156796.</citation>
    <PMID>25961613</PMID>
  </reference>
  <verification_date>September 2021</verification_date>
  <study_first_submitted>May 29, 2020</study_first_submitted>
  <study_first_submitted_qc>June 4, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 9, 2020</study_first_posted>
  <last_update_submitted>September 27, 2021</last_update_submitted>
  <last_update_submitted_qc>September 27, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">September 28, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>University of Sao Paulo</investigator_affiliation>
    <investigator_full_name>Mariana Ragghianti Zangrando</investigator_full_name>
    <investigator_title>Assistant professor</investigator_title>
  </responsible_party>
  <keyword>root exposure</keyword>
  <keyword>periodontal treatment</keyword>
  <keyword>desensitizing agents.</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Periodontal Diseases</mesh_term>
    <mesh_term>Dentin Sensitivity</mesh_term>
    <mesh_term>Hypersensitivity</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Potassium Citrate</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04422184
org study id: DHPP60
nct id: NCT04422184
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
The present project will compare the effect of DH reduction using three different dentifrices
      (Sensodyne Repair and Protect - NOVAMIN technology; Dentalclean Daily Regenerator - REFIX
      technology; Dentalclean Daily Regenerator - REFIX technology + potassium citrate) in
      periodontal patients. The evaluation will be in 6 moments: T1 and T2- immediately before and
      after scaling and root planing (SRP) procedures; T3-after polishing sensitive areas with
      rubbers cups and the dentifrice determined for each group of patients and T4, 5, 6- After 2,
      4 and 8 weeks of SRP. Profissional assessments and patient perception data will be performed.
Periodontal patients may report dentinal hypersensitivity (DH) caused by root surface
      exposure as part of disease process or as a result of periodontal treatment. Although some
      studies evaluated DH reduction using desensitizing toothpastes, no specific chemical/physical
      agent is reported for periodontal patients. Thus, the present project will compare the effect
      of DH reduction using three different dentifrices (Sensodyne Repair and Protect - NOVAMIN
      technology; Dentalclean Daily Regenerator - REFIX technology; Dentalclean Daily Regenerator -
      REFIX technology + potassium citrate) in periodontal patients. This randomized, parallel and
      blinded clinical trial will be divided into 3 groups (SEN GROUP: Sensodyne; REG GROUP:
      Regenerator; REGK GROUP: Regenerator + Potassium Citrate) and evaluated at 6 moments: T1 and
      T2- immediately before and after scaling and root planing (SRP) procedures; T3-after
      polishing sensitive areas with rubbers cups and the dentifrice determined for each group of
      patients and T4, 5, 6- After 2, 4 and 8 weeks of SRP. Air blast sensitivity assessments
      (Schiff scale) and patient perception data on DH will be performed using visual analog scales
      (VAS). The comparison between treatment groups will be done by paired T-test if normal
      distribution is observed or Wilcoxon if non-normal distribution. The significance level
      adopted will be 5% (p <0.05).
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Triple (Participant, Investigator, Outcomes Assessor)
measure: Professional evaluation of Dentin Hypersensitivity
time frame: T1- immediately before scaling and root planing procedures (SRP)
description: Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.
measure: Professional evaluation of Dentin Hypersensitivity
time frame: T2 - immediately after scaling and root planing procedures (SRP)
description: Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.
measure: Professional evaluation of Dentin Hypersensitivity
time frame: T3 - immediately after polishing sensitive areas with rubber cups and the dentifrice determined for each group of patients.
description: Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.
measure: Professional evaluation of Dentin Hypersensitivity
time frame: T4 - 2 weeks after SRP.
description: Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.
measure: Professional evaluation of Dentin Hypersensitivity
time frame: T5 - 4 weeks after SRP.
description: Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.
measure: Professional evaluation of Dentin Hypersensitivity
time frame: T6 - 8 weeks after SRP.
description: Air blast sensitivity evaluated by an experienced dentist (Schiff scale) Score 0 = Tooth/Subject does not show sensitivity in response to air stimulation; 1 = Tooth/Subject responds to air stimulus, but does not request discontinuation of stimulus; 2 = Tooth/Subject responds to air stimulus, and requests discontinuation or moves from stimulus; 3 = Tooth/Subject responds to stimulus, considers stimulus to be painful, and requests discontinuation of the stimulus.
measure: Patient's perception of DH
time frame: T1- immediately before scaling and root planing procedures (SRP)
description: Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.
measure: Patient's perception of DH
time frame: T2 - immediately after scaling and root planing procedures (SRP)
description: Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.
measure: Patient's perception of DH
time frame: T3 - immediately after polishing sensitive areas with rubber cups and the dentifrice determined for each group of patients.
description: Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.
measure: Patient's perception of DH
time frame: T4 - 2 weeks after SRP.
description: Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.
measure: Patient's perception of DH
time frame: T5 - 4 weeks after SRP.
description: Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.
measure: Patient's perception of DH
time frame: T6 - 8 weeks after SRP.
description: Patient's perception of DH was also evaluated with visual analogue scale (VAS), being 0 without any painful sensation and 100 the most painful scenario.
arm group label: SEN GROUP
arm group type: Experimental
description: Sensodyne Repair and Protect - NOVAMIN technology
arm group label: REG GROUP
arm group type: Experimental
description: Dentalclean Daily Regenerator - REFIX technology
arm group label: REGK GROUP
arm group type: Experimental
description: Dentalclean Daily Regenerator - REFIX technology + potassium citrate
intervention type: Drug
intervention name: Sensodyne Repair and Protect
description: Dentifricie with NOVAMIN technology
arm group label: SEN GROUP
other name: Dentifrice with desensitizing agents
intervention type: Drug
intervention name: Dentalclean Daily Regenerator
description: Dentifricie with Refix technology
arm group label: REG GROUP
other name: Dentifrice with desensitizing agents
intervention type: Drug
intervention name: Dentalclean Daily Regenerator with potassium citrate
description: Dentifricie with Refix technology+ potassium citrate
arm group label: REGK GROUP
other name: Dentifrice with desensitizing agents
criteria: 
gender: All
minimum age: 18 Years
maximum age: 70 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Mariana S Ragghianti Zangrando, Prof
role: Principal Investigator
affiliation: USP
last name: Mariana S Ragghianti Zangrando, Prof
phone: 14996962250
email: mariana@fob.usp.br
last name: Giovana Favero
email: giovannaffavero@hotmail.com
facility: 
status: Recruiting
contact: 
contact backup: 
country: Brazil
citation: West NX, Seong J, Davies M. Management of dentine hypersensitivity: efficacy of professionally and self-administered agents. J Clin Periodontol. 2015 Apr;42 Suppl 16:S256-302. doi: 10.1111/jcpe.12336.
PMID: 25495777
citation: Patil SA, Naik BD, Suma R. Evaluation of three different agents for in-office treatment of dentinal hypersensitivity: a controlled clinical study. Indian J Dent Res. 2015 Jan-Feb;26(1):38-42. doi: 10.4103/0970-9290.156796.
PMID: 25961613
responsible party type: Principal Investigator
investigator affiliation: University of Sao Paulo
investigator full name: Mariana Ragghianti Zangrando
investigator title: Assistant professor
mesh term: Periodontal Diseases
mesh term: Dentin Sensitivity
mesh term: Hypersensitivity
mesh term: Potassium Citrate
sharing ipd: No