<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04451538</url>
  </required_header>
  <id_info>
    <org_study_id>2019-322</org_study_id>
    <nct_id>NCT04451538</nct_id>
  </id_info>
  <brief_title>Nutritional Intervention and Outcomes in Elderly After Hip Fracture Surgery</brief_title>
  <official_title>Impact of Perioperative Nutritional Intervention on Perioperative Outcomes of Elderly Patients Having Hip Fracture Surgery: A Randomized Control Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Peking University First Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>The Forth Medical Center of PLA General Hospital</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Tianjin Orthopedic Hospital</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Peking University First Hospital</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
    <is_us_export>Yes</is_us_export>
  </oversight_info>
  <brief_summary>
    <textblock>
      Hip fracture is one of the most frequently occurred injury in the elderly and usually&#xD;
      requires surgical treatment. Malnutrition is common in elderly patients with hip fracture and&#xD;
      is associated with worse outcomes. This study is designed to test the hypothesize that, in&#xD;
      elderly patients with malnutrition or at risk of malnutrition and scheduled for hip-fracture&#xD;
      surgery, perioperative nutritional intervention may reduce early complications and improve&#xD;
      long-term survival.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Elderly patients with hip fracture have a high rate of malnutrition. In a cohort study of hip&#xD;
      fracture patients aged 70 years or older, 18.8% have malnutrition and 44.6% are at risk of&#xD;
      malnutrition. Increasing evidence suggest that preoperative nutritional status has a&#xD;
      significant impact on clinical outcomes of elderly patients following surgery. For example,&#xD;
      preoperative malnutrition or risk of malnutrition is associated with increased delirium,&#xD;
      increased non-delirium complications, prolonged hospital stay, high mortality, and even worse&#xD;
      long-term survival after surgery. We speculate that perioperative nutritional intervention&#xD;
      may reduce postoperative delirium and improve early and long-term clinical outcomes in&#xD;
      elderly hip-fracture patients. The purpose of this study is to observe the effect of&#xD;
      perioperative nutritional intervention on early postoperative delirium and complications as&#xD;
      well as long-term survival in the patients with malnutrition or at risk of malnutrition who&#xD;
      are scheduled for hip-fracture surgery.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Recruiting</overall_status>
  <start_date type="Actual">December 28, 2020</start_date>
  <completion_date type="Anticipated">July 2025</completion_date>
  <primary_completion_date type="Anticipated">June 2025</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Prevention</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Incidence of delirium or non-delirium complications after surgery</measure>
    <time_frame>Up to 30 days after surgery</time_frame>
    <description>Delirium is assessed twice daily with Confusion Assessment Method (CAM) or CAM for the Intensive Care Unit (CAM-ICU) during the first 5 days after surgery. Non-delirium complications indicate newly occurred conditions (other than delirium) that are harmful to patients' recovery and required therapeutic intervention within 30 days after surgery.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Intensive care unit admission after surgery</measure>
    <time_frame>Within 24 hours after surgery</time_frame>
    <description>Intensive care unit admission after surgery</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Length of intensive care unit stay after surgery</measure>
    <time_frame>Up to 30 days after surgery</time_frame>
    <description>Length of intensive care unit stay after surgery</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Incidence of organ injury within 5 days after surgery</measure>
    <time_frame>Up to 5 days after surgery</time_frame>
    <description>Organ injury includes delirium (assessed with CAM/CAM-ICU), acute kidney injury (assessed according to KDIGO [Kidney Disease: Improving Global Outcomes] Criteria), and myocardial injury (cardiac troponin I higher than upper normal limit).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Incidence of non-delirium complications after surgery</measure>
    <time_frame>Up to 30 days after surgery</time_frame>
    <description>Non-delirium complications indicate newly occurred conditions (other than delirium) that are harmful to patients' recovery and required therapeutic intervention within 30 days after surgery.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Length of hospital stay after surgery</measure>
    <time_frame>Up to 30 days after surgery.</time_frame>
    <description>Length of hospital stay after surgery</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cognitive function at 30 days after surgery</measure>
    <time_frame>At 30 days after surgery.</time_frame>
    <description>Cognitive function is assessed with the Modified Telephone Interview for Cognitive Status (TICS-m) which is a 12-item questionnaire that verbally assesses global cognitive function via telephone. The score ranges from 0 to 50, with higher score indicating better function.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Quality of life at 30 days after surgery</measure>
    <time_frame>At 30 days after surgery.</time_frame>
    <description>Quality of life is assessed with the World Health Organization Quality of Life brief version (WHOQOL-BREF) which is a 24-item questionnaire that assesses the quality of life in physical, psychological, social relationship and environmental domains. The score ranges from 0 to 100 for each domain, with higher score indicating better function.</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Pain intensity.</measure>
    <time_frame>During the first 5 days after surgery</time_frame>
    <description>Pain intensity is assessed twice daily (8:00-10:00, 18:00-20:00) with the numeric rating scale (NRS; which is an 11-point scale whereas 0=no pain and 10=the worst pain).</description>
  </other_outcome>
  <other_outcome>
    <measure>Subjective sleep quality.</measure>
    <time_frame>During the first 5 days after surgery</time_frame>
    <description>Subjective sleep quality is assessed once daily (8:00-10:00) with the numeric rating scale (NRS; which is an 11-point scale whereas 0=the best sleep and 10=the worst sleep).</description>
  </other_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">970</enrollment>
  <condition>Elderly Patients</condition>
  <condition>Malnutrition</condition>
  <condition>Hip Fractures</condition>
  <condition>Nutritional Intervention</condition>
  <condition>Perioperative Outcomes</condition>
  <condition>Survival</condition>
  <arm_group>
    <arm_group_label>Nutritional intervention group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Supplemental nutritional support is provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase). For non-diabetic patients, ENSURE is provided (Abbott; 112.6 g [12 spoon, 500 kcal]/day, twice a day); for diabetic patients, GLUCERNA SR is provided (Abbott; 104 g [12 spoon, 440 kcal]/day, twice a day).</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Control group</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Supplemental nutritional support is not provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase).</description>
  </arm_group>
  <intervention>
    <intervention_type>Dietary Supplement</intervention_type>
    <intervention_name>Nutritional intervention group</intervention_name>
    <description>Supplemental nutritional support is provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase). For non-diabetic patients, ENSURE is provided (Abbott; 112.6 g (12 spoons, 500 kcal)/day, twice a day); for diabetic patients, GLUCERNA SR is provided (Abbott; 104 g [12 spoons, 440 kcal]/day, twice a day).</description>
    <arm_group_label>Nutritional intervention group</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Dietary Supplement</intervention_type>
    <intervention_name>Control group</intervention_name>
    <description>Supplemental nutritional support is not provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase).</description>
    <arm_group_label>Control group</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Age ≥70 years old;&#xD;
&#xD;
          -  Hospitalized for hip fracture, scheduled to undergo hip-fracture surgery within 48&#xD;
             hours;&#xD;
&#xD;
          -  Classified as malnutrition or at risk of malnutrition according to the short form&#xD;
             mini-nutrition assessment (MNA-SF);&#xD;
&#xD;
          -  Provide written informed consents.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Pathological fracture;&#xD;
&#xD;
          -  History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis before&#xD;
             surgery;&#xD;
&#xD;
          -  Unable to communicate due to coma, severe dementia, or language barrier;&#xD;
&#xD;
          -  Unable to eat due to any disease in the gastrointestinal system;&#xD;
&#xD;
          -  Severe hepatic dysfunction (Child-Pugh class C), renal failure (requirement of renal&#xD;
             replacement therapy), respiratory failure (requirement of respiratory support),&#xD;
             cardiac insufficiency (New York Heart Association classification ≥IV), or American&#xD;
             Socisty of Anesthesiologists classification ≥IV;&#xD;
&#xD;
          -  Preexisting organ injury before surgery (delirium, acute kidney injury, myocardial&#xD;
             injury, etc.);&#xD;
&#xD;
          -  Other conditions that are considered unsuitable for study participation.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>70 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Dong-Xin Wang, MD, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Peking University First Hospital</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Dong-Mei Ni, MD</last_name>
    <phone>8610 83575138</phone>
    <email>dongmeini@hotmail.com</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Dong-Xin Wang, MD, PhD</last_name>
    <phone>8610 83572784</phone>
    <email>wangdongxin@hotmail.com</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Peking University First Hospital</name>
      <address>
        <city>Beijing</city>
        <state>Beijing</state>
        <zip>100034</zip>
        <country>China</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Dong-Mei Ni, MD</last_name>
      <phone>8610 83575138</phone>
      <email>dongmeini@hotmail.com</email>
    </contact>
  </location>
  <location>
    <facility>
      <name>Fourth Medical Center of PLA General Hospital</name>
      <address>
        <city>Beijing</city>
        <state>Beijing</state>
        <zip>100048</zip>
        <country>China</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Meng-Meng Li, MD</last_name>
      <email>mmli2@yahoo.com</email>
    </contact>
  </location>
  <location>
    <facility>
      <name>Tianjin Orthopedic Hospital</name>
      <address>
        <city>Tianjin</city>
        <state>Tianjin</state>
        <country>China</country>
      </address>
    </facility>
    <status>Not yet recruiting</status>
    <contact>
      <last_name>Jin Xu, MD</last_name>
    </contact>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
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    <citation>Inoue T, Misu S, Tanaka T, Kakehi T, Ono R. Acute phase nutritional screening tool associated with functional outcomes of hip fracture patients: A longitudinal study to compare MNA-SF, MUST, NRS-2002 and GNRI. Clin Nutr. 2019 Feb;38(1):220-226. doi: 10.1016/j.clnu.2018.01.030. Epub 2018 Feb 15.</citation>
    <PMID>29456030</PMID>
  </reference>
  <reference>
    <citation>O'Hara DA, Duff A, Berlin JA, Poses RM, Lawrence VA, Huber EC, Noveck H, Strom BL, Carson JL. The effect of anesthetic technique on postoperative outcomes in hip fracture repair. Anesthesiology. 2000 Apr;92(4):947-57. doi: 10.1097/00000542-200004000-00011.</citation>
    <PMID>10754613</PMID>
  </reference>
  <reference>
    <citation>Neuman MD, Silber JH, Elkassabany NM, Ludwig JM, Fleisher LA. Comparative effectiveness of regional versus general anesthesia for hip fracture surgery in adults. Anesthesiology. 2012 Jul;117(1):72-92. doi: 10.1097/ALN.0b013e3182545e7c.</citation>
    <PMID>22713634</PMID>
  </reference>
  <reference>
    <citation>Fields AC, Dieterich JD, Buterbaugh K, Moucha CS. Short-term complications in hip fracture surgery using spinal versus general anaesthesia. Injury. 2015 Apr;46(4):719-23. doi: 10.1016/j.injury.2015.02.002. Epub 2015 Feb 11.</citation>
    <PMID>25704139</PMID>
  </reference>
  <reference>
    <citation>Neuman MD, Rosenbaum PR, Ludwig JM, Zubizarreta JR, Silber JH. Anesthesia technique, mortality, and length of stay after hip fracture surgery. JAMA. 2014 Jun 25;311(24):2508-17. doi: 10.1001/jama.2014.6499.</citation>
    <PMID>25058085</PMID>
  </reference>
  <reference>
    <citation>Patorno E, Neuman MD, Schneeweiss S, Mogun H, Bateman BT. Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study. BMJ. 2014 Jun 27;348:g4022. doi: 10.1136/bmj.g4022.</citation>
    <PMID>24972901</PMID>
  </reference>
  <reference>
    <citation>Robinson TN, Walston JD, Brummel NE, Deiner S, Brown CH 4th, Kennedy M, Hurria A. Frailty for Surgeons: Review of a National Institute on Aging Conference on Frailty for Specialists. J Am Coll Surg. 2015 Dec;221(6):1083-92. doi: 10.1016/j.jamcollsurg.2015.08.428. Epub 2015 Sep 11. No abstract available.</citation>
    <PMID>26422746</PMID>
  </reference>
  <verification_date>July 2021</verification_date>
  <study_first_submitted>June 26, 2020</study_first_submitted>
  <study_first_submitted_qc>June 26, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 30, 2020</study_first_posted>
  <last_update_submitted>July 10, 2021</last_update_submitted>
  <last_update_submitted_qc>July 10, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">July 16, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Peking University First Hospital</investigator_affiliation>
    <investigator_full_name>Dong-Xin Wang</investigator_full_name>
    <investigator_title>Professor and Chairman, Department of Anesthesiology and Critical Care Medicine</investigator_title>
  </responsible_party>
  <keyword>Elderly patients</keyword>
  <keyword>Malnutrition</keyword>
  <keyword>Hip Fractures</keyword>
  <keyword>Nutritional intervention</keyword>
  <keyword>Perioperative outcomes</keyword>
  <keyword>Long-term survival</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Malnutrition</mesh_term>
    <mesh_term>Fractures, Bone</mesh_term>
    <mesh_term>Hip Fractures</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04451538
org study id: 2019-322
nct id: NCT04451538
lead sponsor: 
collaborator: 
collaborator: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
is us export: Yes
Hip fracture is one of the most frequently occurred injury in the elderly and usually
      requires surgical treatment. Malnutrition is common in elderly patients with hip fracture and
      is associated with worse outcomes. This study is designed to test the hypothesize that, in
      elderly patients with malnutrition or at risk of malnutrition and scheduled for hip-fracture
      surgery, perioperative nutritional intervention may reduce early complications and improve
      long-term survival.
Elderly patients with hip fracture have a high rate of malnutrition. In a cohort study of hip
      fracture patients aged 70 years or older, 18.8% have malnutrition and 44.6% are at risk of
      malnutrition. Increasing evidence suggest that preoperative nutritional status has a
      significant impact on clinical outcomes of elderly patients following surgery. For example,
      preoperative malnutrition or risk of malnutrition is associated with increased delirium,
      increased non-delirium complications, prolonged hospital stay, high mortality, and even worse
      long-term survival after surgery. We speculate that perioperative nutritional intervention
      may reduce postoperative delirium and improve early and long-term clinical outcomes in
      elderly hip-fracture patients. The purpose of this study is to observe the effect of
      perioperative nutritional intervention on early postoperative delirium and complications as
      well as long-term survival in the patients with malnutrition or at risk of malnutrition who
      are scheduled for hip-fracture surgery.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Prevention
masking: None (Open Label)
measure: Incidence of delirium or non-delirium complications after surgery
time frame: Up to 30 days after surgery
description: Delirium is assessed twice daily with Confusion Assessment Method (CAM) or CAM for the Intensive Care Unit (CAM-ICU) during the first 5 days after surgery. Non-delirium complications indicate newly occurred conditions (other than delirium) that are harmful to patients' recovery and required therapeutic intervention within 30 days after surgery.
measure: Intensive care unit admission after surgery
time frame: Within 24 hours after surgery
description: Intensive care unit admission after surgery
measure: Length of intensive care unit stay after surgery
time frame: Up to 30 days after surgery
description: Length of intensive care unit stay after surgery
measure: Incidence of organ injury within 5 days after surgery
time frame: Up to 5 days after surgery
description: Organ injury includes delirium (assessed with CAM/CAM-ICU), acute kidney injury (assessed according to KDIGO [Kidney Disease: Improving Global Outcomes] Criteria), and myocardial injury (cardiac troponin I higher than upper normal limit).
measure: Incidence of non-delirium complications after surgery
time frame: Up to 30 days after surgery
description: Non-delirium complications indicate newly occurred conditions (other than delirium) that are harmful to patients' recovery and required therapeutic intervention within 30 days after surgery.
measure: Length of hospital stay after surgery
time frame: Up to 30 days after surgery.
description: Length of hospital stay after surgery
measure: Cognitive function at 30 days after surgery
time frame: At 30 days after surgery.
description: Cognitive function is assessed with the Modified Telephone Interview for Cognitive Status (TICS-m) which is a 12-item questionnaire that verbally assesses global cognitive function via telephone. The score ranges from 0 to 50, with higher score indicating better function.
measure: Quality of life at 30 days after surgery
time frame: At 30 days after surgery.
description: Quality of life is assessed with the World Health Organization Quality of Life brief version (WHOQOL-BREF) which is a 24-item questionnaire that assesses the quality of life in physical, psychological, social relationship and environmental domains. The score ranges from 0 to 100 for each domain, with higher score indicating better function.
measure: Pain intensity.
time frame: During the first 5 days after surgery
description: Pain intensity is assessed twice daily (8:00-10:00, 18:00-20:00) with the numeric rating scale (NRS; which is an 11-point scale whereas 0=no pain and 10=the worst pain).
measure: Subjective sleep quality.
time frame: During the first 5 days after surgery
description: Subjective sleep quality is assessed once daily (8:00-10:00) with the numeric rating scale (NRS; which is an 11-point scale whereas 0=the best sleep and 10=the worst sleep).
arm group label: Nutritional intervention group
arm group type: Experimental
description: Supplemental nutritional support is provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase). For non-diabetic patients, ENSURE is provided (Abbott; 112.6 g [12 spoon, 500 kcal]/day, twice a day); for diabetic patients, GLUCERNA SR is provided (Abbott; 104 g [12 spoon, 440 kcal]/day, twice a day).
arm group label: Control group
arm group type: Placebo Comparator
description: Supplemental nutritional support is not provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase).
intervention type: Dietary Supplement
intervention name: Nutritional intervention group
description: Supplemental nutritional support is provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase). For non-diabetic patients, ENSURE is provided (Abbott; 112.6 g (12 spoons, 500 kcal)/day, twice a day); for diabetic patients, GLUCERNA SR is provided (Abbott; 104 g [12 spoons, 440 kcal]/day, twice a day).
arm group label: Nutritional intervention group
intervention type: Dietary Supplement
intervention name: Control group
description: Supplemental nutritional support is not provided in addition to normal diet during the perioperative period (five days from pre- to postoperative phase).
arm group label: Control group
criteria: 
gender: All
minimum age: 70 Years
maximum age: N/A
healthy volunteers: No
last name: Dong-Xin Wang, MD, PhD
role: Principal Investigator
affiliation: Peking University First Hospital
last name: Dong-Mei Ni, MD
phone: 8610 83575138
email: dongmeini@hotmail.com
last name: Dong-Xin Wang, MD, PhD
phone: 8610 83572784
email: wangdongxin@hotmail.com
facility: 
status: Recruiting
contact: 
facility: 
status: Recruiting
contact: 
facility: 
status: Not yet recruiting
contact: 
country: China
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PMID: 26967259
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citation: Inoue T, Misu S, Tanaka T, Kakehi T, Ono R. Acute phase nutritional screening tool associated with functional outcomes of hip fracture patients: A longitudinal study to compare MNA-SF, MUST, NRS-2002 and GNRI. Clin Nutr. 2019 Feb;38(1):220-226. doi: 10.1016/j.clnu.2018.01.030. Epub 2018 Feb 15.
PMID: 29456030
citation: O'Hara DA, Duff A, Berlin JA, Poses RM, Lawrence VA, Huber EC, Noveck H, Strom BL, Carson JL. The effect of anesthetic technique on postoperative outcomes in hip fracture repair. Anesthesiology. 2000 Apr;92(4):947-57. doi: 10.1097/00000542-200004000-00011.
PMID: 10754613
citation: Neuman MD, Silber JH, Elkassabany NM, Ludwig JM, Fleisher LA. Comparative effectiveness of regional versus general anesthesia for hip fracture surgery in adults. Anesthesiology. 2012 Jul;117(1):72-92. doi: 10.1097/ALN.0b013e3182545e7c.
PMID: 22713634
citation: Fields AC, Dieterich JD, Buterbaugh K, Moucha CS. Short-term complications in hip fracture surgery using spinal versus general anaesthesia. Injury. 2015 Apr;46(4):719-23. doi: 10.1016/j.injury.2015.02.002. Epub 2015 Feb 11.
PMID: 25704139
citation: Neuman MD, Rosenbaum PR, Ludwig JM, Zubizarreta JR, Silber JH. Anesthesia technique, mortality, and length of stay after hip fracture surgery. JAMA. 2014 Jun 25;311(24):2508-17. doi: 10.1001/jama.2014.6499.
PMID: 25058085
citation: Patorno E, Neuman MD, Schneeweiss S, Mogun H, Bateman BT. Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study. BMJ. 2014 Jun 27;348:g4022. doi: 10.1136/bmj.g4022.
PMID: 24972901
citation: Robinson TN, Walston JD, Brummel NE, Deiner S, Brown CH 4th, Kennedy M, Hurria A. Frailty for Surgeons: Review of a National Institute on Aging Conference on Frailty for Specialists. J Am Coll Surg. 2015 Dec;221(6):1083-92. doi: 10.1016/j.jamcollsurg.2015.08.428. Epub 2015 Sep 11. No abstract available.
PMID: 26422746
responsible party type: Principal Investigator
investigator affiliation: Peking University First Hospital
investigator full name: Dong-Xin Wang
investigator title: Professor and Chairman, Department of Anesthesiology and Critical Care Medicine
mesh term: Malnutrition
mesh term: Fractures, Bone
mesh term: Hip Fractures
sharing ipd: No