<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04499937</url>
  </required_header>
  <id_info>
    <org_study_id>16-013326</org_study_id>
    <nct_id>NCT04499937</nct_id>
  </id_info>
  <brief_title>ReCoUPS: Post-Concussion Patient Reports</brief_title>
  <official_title>ReCoUPS: Incentive-Based and Real-Time Symptom and Activity Reporting After Concussion</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Children's Hospital of Philadelphia</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>University of Pennsylvania</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Children's Hospital of Philadelphia</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Physical and cognitive rest are recommended as treatment for concussion, but debate persists&#xD;
      about the utility of this recommendation for patients recovering from concussion. In&#xD;
      addition, patient adherence to physical and cognitive rest recommendations after concussion&#xD;
      remains unknown. This study will measure and compare symptom and activity reports in the days&#xD;
      and weeks after a concussion among patients randomly assigned to different incentive-based&#xD;
      arms.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Although physical and cognitive rest are recommended as the hallmark treatment for&#xD;
      concussion, debate persists about the utility of this recommendation for patients recovering&#xD;
      from a concussion. In addition, patient adherence to physical and cognitive rest&#xD;
      recommendations after concussion remains unknown. Objective and timely measures of physical&#xD;
      and cognitive activity will aid in defining the relationship between physical and cognitive&#xD;
      rest and clinical outcomes, such as symptom status, in the days and weeks after a concussion.&#xD;
      Random assignment to incentive-based arms will be used to measure patient engagement with the&#xD;
      study protocol and a dedicated research platform that involves ecological momentary&#xD;
      assessment (EMA), in which participants report their real-time symptoms and daily activities&#xD;
      in response to randomly timed prompts, will be used to help assess the rest and recovery&#xD;
      process among pediatric and adult patients after concussion.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">March 3, 2019</start_date>
  <completion_date type="Actual">February 5, 2021</completion_date>
  <primary_completion_date type="Actual">December 31, 2020</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Participant adherence to completing daily survey</measure>
    <time_frame>21 days</time_frame>
    <description>This is a study where each participant is sent a short survey (PCSI instrument) three times each day for 21 days. The participant is instructed to reply to each survey within several minutes of receiving the prompt. We are interested in the extent to which participants will adhere to this instruction. Therefore, the outcome of interest is whether or not the participant replied to a given survey prompt. When we evaluate patient adherence in the data, we do this by calculating the % of survey prompts to which a given participant responded. In sum, the outcome is adherence to the survey.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Time to recovery</measure>
    <time_frame>1 to 21 days</time_frame>
    <description>Assess and quantify the concussion recovery process by monitoring symptoms and cognitive and physical activity on a daily basis.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Correlation between symptoms and physical activity</measure>
    <time_frame>1-21 days</time_frame>
    <description>Determine if there is a correlation each day between the daily symptom score from the PCSI (0-126) and the number of hours spent exercising (physical activity).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient-reported activity vs. objective measures of activity</measure>
    <time_frame>1-21 days</time_frame>
    <description>Compare the patient-reported hours spent exercising on a given day to the patient's daily step count collected through Fitbit on that same day.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Test Way to Health platform</measure>
    <time_frame>1-21 days</time_frame>
    <description>Test Way to Health as a platform for efficiently randomizing and monitoring patients</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Correlation between symptoms and cognitive activity</measure>
    <time_frame>1-21 days</time_frame>
    <description>Determine if there is a correlation each day between the daily symptom score from the PCSI (0-126) and the number of hours participants spent doing homework, napping, and using screens combined (cognitive activity).</description>
  </secondary_outcome>
  <number_of_arms>4</number_of_arms>
  <enrollment type="Actual">30</enrollment>
  <condition>Brain Concussion</condition>
  <condition>Head Injury</condition>
  <arm_group>
    <arm_group_label>Streak incentive</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Subjects start with no money in an account, but they earn a fixed amount with each response. In this arm, each adult report is worth $3.17 so an adult subject can earn up to $200 if he/she responds to all surveys. If an adult completes at least 75% of the reports, he/she will receive an $100 bonus for a total maximum of $300. In this arm, each child report is worth 0.52 cents so a child subject can earn up to $33 if he/she responds to all surveys. If a child completes at least 75% of the reports, he/she will receive a $17 bonus for a total maximum of $50.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Loss-based incentive</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Subjects start with the maximum possible compensation, but money is deducted for each missed response. Adult subjects will lose $4.76 for each missed survey. Child subjects will lose $0.79 for each missed survey.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Flat-fee control status quo condition</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Subjects will receive the maximum possible compensation at the end of the study regardless of response rate.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Flat-Fitbit control status quo condition</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Subjects will be compensated by keeping the Fitbit at the end of the study regardless of response rate.</description>
  </arm_group>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Streak incentive</intervention_name>
    <description>Participants will receive prompts 3 times a day for 21 days prompting them to complete surveys. They will start with a $0 balance and will earn a fixed amount for each response.</description>
    <arm_group_label>Streak incentive</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Loss-based incentive</intervention_name>
    <description>Participants will receive prompts 3 times a day for 21 days prompting them to complete surveys. They will start with the maximum balance and will lose a fixed amount for each response they do not complete.</description>
    <arm_group_label>Loss-based incentive</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Flat-fee control status quo condition</intervention_name>
    <description>Participants will receive prompts 3 times a day for 21 days prompting them to complete surveys. They will receive the maximum compensation at the end of the study.</description>
    <arm_group_label>Flat-fee control status quo condition</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Flat-Fitbit control status quo condition</intervention_name>
    <description>Participants will receive prompts 3 times a day for 21 days prompting them to complete surveys. They will keep the Fitbit at the end of the study.</description>
    <arm_group_label>Flat-Fitbit control status quo condition</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Males or females ages 13 to 64 years.&#xD;
&#xD;
          -  Presents with head injury concerning for concussion in line with criteria specified in&#xD;
             the most recent Consensus Statement on Concussion in Sport, defined as head trauma&#xD;
             with neurologic impairment, including, but not limited to somatic (eg, headache),&#xD;
             cognitive (eg, feeling like in a fog) and/or emotional symptoms (eg, lability)&#xD;
             symptoms.&#xD;
&#xD;
          -  Within approximately 5 days of injury.&#xD;
&#xD;
          -  Ownership of a smartphone to report symptoms and activities.&#xD;
&#xD;
          -  Speak English.&#xD;
&#xD;
          -  Informed consent or parental/guardian permission and child assent for those under 18&#xD;
             years of age.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Parents/guardians or subjects who, in the opinion of the Investigator, may be&#xD;
             non-compliant with study schedules or procedures.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>13 Years</minimum_age>
    <maximum_age>64 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Douglas Wiebe, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Pennsylvania</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Daniel Corwin, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Children's Hospital of Philadelphia</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Christina Master, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Children's Hospital of Philadelphia</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Children's Hospital of Philadelphia</name>
      <address>
        <city>Philadelphia</city>
        <state>Pennsylvania</state>
        <zip>19104</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>The University of Pennsylvania</name>
      <address>
        <city>Philadelphia</city>
        <state>Pennsylvania</state>
        <zip>19104</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <reference>
    <citation>Korley FK, Kelen GD, Jones CM, Diaz-Arrastia R. Emergency Department Evaluation of Traumatic Brain Injury in the United States, 2009-2010. J Head Trauma Rehabil. 2016 Nov/Dec;31(6):379-387. doi: 10.1097/HTR.0000000000000187.</citation>
    <PMID>26360006</PMID>
  </reference>
  <reference>
    <citation>McCrea M, Guskiewicz KM, Marshall SW, Barr W, Randolph C, Cantu RC, Onate JA, Yang J, Kelly JP. Acute effects and recovery time following concussion in collegiate football players: the NCAA Concussion Study. JAMA. 2003 Nov 19;290(19):2556-63. doi: 10.1001/jama.290.19.2556.</citation>
    <PMID>14625332</PMID>
  </reference>
  <reference>
    <citation>Leddy JJ, Baker JG, Kozlowski K, Bisson L, Willer B. Reliability of a graded exercise test for assessing recovery from concussion. Clin J Sport Med. 2011 Mar;21(2):89-94. doi: 10.1097/JSM.0b013e3181fdc721.</citation>
    <PMID>21358497</PMID>
  </reference>
  <reference>
    <citation>Brown NJ, Mannix RC, O'Brien MJ, Gostine D, Collins MW, Meehan WP 3rd. Effect of cognitive activity level on duration of post-concussion symptoms. Pediatrics. 2014 Feb;133(2):e299-304. doi: 10.1542/peds.2013-2125. Epub 2014 Jan 6.</citation>
    <PMID>24394679</PMID>
  </reference>
  <reference>
    <citation>McCrory P, Meeuwisse WH, Aubry M, Cantu B, Dvorak J, Echemendia RJ, Engebretsen L, Johnston K, Kutcher JS, Raftery M, Sills A, Benson BW, Davis GA, Ellenbogen RG, Guskiewicz K, Herring SA, Iverson GL, Jordan BD, Kissick J, McCrea M, McIntosh AS, Maddocks D, Makdissi M, Purcell L, Putukian M, Schneider K, Tator CH, Turner M. Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med. 2013 Apr;47(5):250-8. doi: 10.1136/bjsports-2013-092313. No abstract available.</citation>
    <PMID>23479479</PMID>
  </reference>
  <reference>
    <citation>Moor HM, Eisenhauer RC, Killian KD, Proudfoot N, Henriques AA, Congeni JA, Reneker JC. The relationship between adherence behaviors and recovery time in adolescents after a sports-related concussion: an observational study. Int J Sports Phys Ther. 2015 Apr;10(2):225-33.</citation>
    <PMID>25883871</PMID>
  </reference>
  <reference>
    <citation>Meehan WP 3rd, Bachur RG. The recommendation for rest following acute concussion. Pediatrics. 2015 Feb;135(2):362-3. doi: 10.1542/peds.2014-3665. Epub 2015 Jan 5. No abstract available.</citation>
    <PMID>25560439</PMID>
  </reference>
  <reference>
    <citation>Thomas DG, Apps JN, Hoffmann RG, McCrea M, Hammeke T. Benefits of strict rest after acute concussion: a randomized controlled trial. Pediatrics. 2015 Feb;135(2):213-23. doi: 10.1542/peds.2014-0966. Epub 2015 Jan 5.</citation>
    <PMID>25560444</PMID>
  </reference>
  <reference>
    <citation>Schneider KJ, Iverson GL, Emery CA, McCrory P, Herring SA, Meeuwisse WH. The effects of rest and treatment following sport-related concussion: a systematic review of the literature. Br J Sports Med. 2013 Apr;47(5):304-7. doi: 10.1136/bjsports-2013-092190.</citation>
    <PMID>23479489</PMID>
  </reference>
  <reference>
    <citation>Wiebe DJ, Nance ML, Houseknecht E, Grady MF, Otto N, Sandsmark DK, Master CL. Ecologic Momentary Assessment to Accomplish Real-Time Capture of Symptom Progression and the Physical and Cognitive Activities of Patients Daily Following Concussion. JAMA Pediatr. 2016 Nov 1;170(11):1108-1110. doi: 10.1001/jamapediatrics.2016.1979. No abstract available.</citation>
    <PMID>27617669</PMID>
  </reference>
  <verification_date>October 2021</verification_date>
  <study_first_submitted>July 20, 2020</study_first_submitted>
  <study_first_submitted_qc>July 31, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">August 5, 2020</study_first_posted>
  <last_update_submitted>October 22, 2021</last_update_submitted>
  <last_update_submitted_qc>October 22, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">October 25, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Craniocerebral Trauma</mesh_term>
    <mesh_term>Brain Concussion</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04499937
org study id: 16-013326
nct id: NCT04499937
lead sponsor: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Physical and cognitive rest are recommended as treatment for concussion, but debate persists
      about the utility of this recommendation for patients recovering from concussion. In
      addition, patient adherence to physical and cognitive rest recommendations after concussion
      remains unknown. This study will measure and compare symptom and activity reports in the days
      and weeks after a concussion among patients randomly assigned to different incentive-based
      arms.
Although physical and cognitive rest are recommended as the hallmark treatment for
      concussion, debate persists about the utility of this recommendation for patients recovering
      from a concussion. In addition, patient adherence to physical and cognitive rest
      recommendations after concussion remains unknown. Objective and timely measures of physical
      and cognitive activity will aid in defining the relationship between physical and cognitive
      rest and clinical outcomes, such as symptom status, in the days and weeks after a concussion.
      Random assignment to incentive-based arms will be used to measure patient engagement with the
      study protocol and a dedicated research platform that involves ecological momentary
      assessment (EMA), in which participants report their real-time symptoms and daily activities
      in response to randomly timed prompts, will be used to help assess the rest and recovery
      process among pediatric and adult patients after concussion.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Participant adherence to completing daily survey
time frame: 21 days
description: This is a study where each participant is sent a short survey (PCSI instrument) three times each day for 21 days. The participant is instructed to reply to each survey within several minutes of receiving the prompt. We are interested in the extent to which participants will adhere to this instruction. Therefore, the outcome of interest is whether or not the participant replied to a given survey prompt. When we evaluate patient adherence in the data, we do this by calculating the % of survey prompts to which a given participant responded. In sum, the outcome is adherence to the survey.
measure: Time to recovery
time frame: 1 to 21 days
description: Assess and quantify the concussion recovery process by monitoring symptoms and cognitive and physical activity on a daily basis.
measure: Correlation between symptoms and physical activity
time frame: 1-21 days
description: Determine if there is a correlation each day between the daily symptom score from the PCSI (0-126) and the number of hours spent exercising (physical activity).
measure: Patient-reported activity vs. objective measures of activity
time frame: 1-21 days
description: Compare the patient-reported hours spent exercising on a given day to the patient's daily step count collected through Fitbit on that same day.
measure: Test Way to Health platform
time frame: 1-21 days
description: Test Way to Health as a platform for efficiently randomizing and monitoring patients
measure: Correlation between symptoms and cognitive activity
time frame: 1-21 days
description: Determine if there is a correlation each day between the daily symptom score from the PCSI (0-126) and the number of hours participants spent doing homework, napping, and using screens combined (cognitive activity).
arm group label: Streak incentive
arm group type: Experimental
description: Subjects start with no money in an account, but they earn a fixed amount with each response. In this arm, each adult report is worth $3.17 so an adult subject can earn up to $200 if he/she responds to all surveys. If an adult completes at least 75% of the reports, he/she will receive an $100 bonus for a total maximum of $300. In this arm, each child report is worth 0.52 cents so a child subject can earn up to $33 if he/she responds to all surveys. If a child completes at least 75% of the reports, he/she will receive a $17 bonus for a total maximum of $50.
arm group label: Loss-based incentive
arm group type: Experimental
description: Subjects start with the maximum possible compensation, but money is deducted for each missed response. Adult subjects will lose $4.76 for each missed survey. Child subjects will lose $0.79 for each missed survey.
arm group label: Flat-fee control status quo condition
arm group type: Active Comparator
description: Subjects will receive the maximum possible compensation at the end of the study regardless of response rate.
arm group label: Flat-Fitbit control status quo condition
arm group type: Active Comparator
description: Subjects will be compensated by keeping the Fitbit at the end of the study regardless of response rate.
intervention type: Behavioral
intervention name: Streak incentive
description: Participants will receive prompts 3 times a day for 21 days prompting them to complete surveys. They will start with a $0 balance and will earn a fixed amount for each response.
arm group label: Streak incentive
intervention type: Behavioral
intervention name: Loss-based incentive
description: Participants will receive prompts 3 times a day for 21 days prompting them to complete surveys. They will start with the maximum balance and will lose a fixed amount for each response they do not complete.
arm group label: Loss-based incentive
intervention type: Behavioral
intervention name: Flat-fee control status quo condition
description: Participants will receive prompts 3 times a day for 21 days prompting them to complete surveys. They will receive the maximum compensation at the end of the study.
arm group label: Flat-fee control status quo condition
intervention type: Behavioral
intervention name: Flat-Fitbit control status quo condition
description: Participants will receive prompts 3 times a day for 21 days prompting them to complete surveys. They will keep the Fitbit at the end of the study.
arm group label: Flat-Fitbit control status quo condition
criteria: 
gender: All
minimum age: 13 Years
maximum age: 64 Years
healthy volunteers: No
last name: Douglas Wiebe, PhD
role: Principal Investigator
affiliation: University of Pennsylvania
last name: Daniel Corwin, MD
role: Principal Investigator
affiliation: Children's Hospital of Philadelphia
last name: Christina Master, MD
role: Principal Investigator
affiliation: Children's Hospital of Philadelphia
facility: 
facility: 
country: United States
citation: Korley FK, Kelen GD, Jones CM, Diaz-Arrastia R. Emergency Department Evaluation of Traumatic Brain Injury in the United States, 2009-2010. J Head Trauma Rehabil. 2016 Nov/Dec;31(6):379-387. doi: 10.1097/HTR.0000000000000187.
PMID: 26360006
citation: McCrea M, Guskiewicz KM, Marshall SW, Barr W, Randolph C, Cantu RC, Onate JA, Yang J, Kelly JP. Acute effects and recovery time following concussion in collegiate football players: the NCAA Concussion Study. JAMA. 2003 Nov 19;290(19):2556-63. doi: 10.1001/jama.290.19.2556.
PMID: 14625332
citation: Leddy JJ, Baker JG, Kozlowski K, Bisson L, Willer B. Reliability of a graded exercise test for assessing recovery from concussion. Clin J Sport Med. 2011 Mar;21(2):89-94. doi: 10.1097/JSM.0b013e3181fdc721.
PMID: 21358497
citation: Brown NJ, Mannix RC, O'Brien MJ, Gostine D, Collins MW, Meehan WP 3rd. Effect of cognitive activity level on duration of post-concussion symptoms. Pediatrics. 2014 Feb;133(2):e299-304. doi: 10.1542/peds.2013-2125. Epub 2014 Jan 6.
PMID: 24394679
citation: McCrory P, Meeuwisse WH, Aubry M, Cantu B, Dvorak J, Echemendia RJ, Engebretsen L, Johnston K, Kutcher JS, Raftery M, Sills A, Benson BW, Davis GA, Ellenbogen RG, Guskiewicz K, Herring SA, Iverson GL, Jordan BD, Kissick J, McCrea M, McIntosh AS, Maddocks D, Makdissi M, Purcell L, Putukian M, Schneider K, Tator CH, Turner M. Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med. 2013 Apr;47(5):250-8. doi: 10.1136/bjsports-2013-092313. No abstract available.
PMID: 23479479
citation: Moor HM, Eisenhauer RC, Killian KD, Proudfoot N, Henriques AA, Congeni JA, Reneker JC. The relationship between adherence behaviors and recovery time in adolescents after a sports-related concussion: an observational study. Int J Sports Phys Ther. 2015 Apr;10(2):225-33.
PMID: 25883871
citation: Meehan WP 3rd, Bachur RG. The recommendation for rest following acute concussion. Pediatrics. 2015 Feb;135(2):362-3. doi: 10.1542/peds.2014-3665. Epub 2015 Jan 5. No abstract available.
PMID: 25560439
citation: Thomas DG, Apps JN, Hoffmann RG, McCrea M, Hammeke T. Benefits of strict rest after acute concussion: a randomized controlled trial. Pediatrics. 2015 Feb;135(2):213-23. doi: 10.1542/peds.2014-0966. Epub 2015 Jan 5.
PMID: 25560444
citation: Schneider KJ, Iverson GL, Emery CA, McCrory P, Herring SA, Meeuwisse WH. The effects of rest and treatment following sport-related concussion: a systematic review of the literature. Br J Sports Med. 2013 Apr;47(5):304-7. doi: 10.1136/bjsports-2013-092190.
PMID: 23479489
citation: Wiebe DJ, Nance ML, Houseknecht E, Grady MF, Otto N, Sandsmark DK, Master CL. Ecologic Momentary Assessment to Accomplish Real-Time Capture of Symptom Progression and the Physical and Cognitive Activities of Patients Daily Following Concussion. JAMA Pediatr. 2016 Nov 1;170(11):1108-1110. doi: 10.1001/jamapediatrics.2016.1979. No abstract available.
PMID: 27617669
responsible party type: Sponsor
mesh term: Craniocerebral Trauma
mesh term: Brain Concussion
sharing ipd: No