<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04464382</url>
  </required_header>
  <id_info>
    <org_study_id>PENDI_CSI</org_study_id>
    <nct_id>NCT04464382</nct_id>
  </id_info>
  <brief_title>Evaluating the Safety and Efficacy of a Outpatient Appendectomy</brief_title>
  <acronym>PENDI_CSI</acronym>
  <official_title>A Randomized Double-blind Clinical Trial to Evaluate the Safety and Efficacy of a Outpatient Appendectomy (PENDI_CSI)</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Fundación Pública Andaluza para la gestión de la Investigación en Sevilla</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Fundación Pública Andaluza para la gestión de la Investigación en Sevilla</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This study evaluates the Safety and Efficacy of a outpatient appendectomy. Half of&#xD;
      participants will be perform the hospitalization, while the other half will undergo the&#xD;
      outpatient appendectomy&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Acute appendicitis (AA) is one of the most common causes of acute abdomen and one of the most&#xD;
      frequent diagnoses that require urgent surgery worldwide.&#xD;
&#xD;
      Many laparoscopic procedures are currently performed on an outpatient basis.Laparoscopic&#xD;
      appendectomy, however, continues to require postoperative hospitalization averaging between 1&#xD;
      and 2 days, at most institutions.&#xD;
&#xD;
      At present ambulatory laparoscopic appendectomy (LA) are gained popularity due to the&#xD;
      improved understanding of patient selection criteria, the application of enhanced recovery&#xD;
      pathways, and the potential for improving healthcare resource utilization.&#xD;
&#xD;
      There are few studies about to compare the morbidity and readmission rates between ambulatory&#xD;
      and conventional LA.&#xD;
&#xD;
      There is a lack of high-quality comparative studies making conclusive recommendations not&#xD;
      possible at this time. Based on current data, ambulatory LA may be safe and feasible as&#xD;
      compared with conventional LA.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">April 28, 2019</start_date>
  <completion_date type="Anticipated">October 28, 2021</completion_date>
  <primary_completion_date type="Anticipated">April 28, 2021</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Health Services Research</primary_purpose>
    <masking>Double (Participant, Investigator)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Rates of ambulatory appendectomy patients that have ambulatory surgery</measure>
    <time_frame>20 months</time_frame>
    <description>Analyze morbidity of appendectomy patients to determine the safety of ambulatory surgery</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Rates of readmission of appendectomy patients that had ambulatory surgery</measure>
    <time_frame>20 months</time_frame>
    <description>Analyze rates of readmission of appendectomy patients to determine the safety of ambulatory surgery</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Prevalence of ambulatory appendectomy patients</measure>
    <time_frame>20 months</time_frame>
    <description>Measure the percentage of ambulatory surgery and uncomplicated acute appendicitis vs the percentage of ambulatory surgery in failure patients with the same pathology e.g.&#xD;
Uncontrolled abdominal pain with analgesia.&#xD;
Upper airway discomfort related to intubation that is not controlled with medication.&#xD;
Pain in the back or shoulders in relation to the pneumoperitoneum that are in patients with not controlled with the medication.&#xD;
Hemodynamically abnormal. Uncontrolled bleeding at the level of any of the wounds. Need for reoperation. Need to re-enter or consult the Emergency Service No spontaneous urination.&#xD;
Nausea / vomiting.&#xD;
Oral intolerance.&#xD;
No wandering.&#xD;
Insecurity or fear of the patient at discharge.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Media of time until the total incorporation to the activities of the daily life after appendectomy</measure>
    <time_frame>20 months</time_frame>
    <description>To value the time until the total incorporation to the activities of the daily life after appendectomy.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Rates of satisfaction</measure>
    <time_frame>20 months</time_frame>
    <description>Measure the degree of satisfaction of our patients with outpatient management after appendectomy, using a satisfaction questionnaire.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Costs of the outpatient regimen versus the hospitalization of patients</measure>
    <time_frame>20 months</time_frame>
    <description>Compare the costs of the outpatient regimen versus the hospitalization of patients with uncomplicated acute appendicitis (cost-minimization analysis).</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">291</enrollment>
  <condition>Appendicitis Acute</condition>
  <condition>Appendectomy</condition>
  <arm_group>
    <arm_group_label>Outpatient appendectomy</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Patients with acute uncomplicated appendicitis that require emergency appendectomy. The intervention will be the classic.Once the appendectomy is performed, all the selection criteria will be reassessed and the definitive inclusion of the patients will be performed.&#xD;
Patients after surgery will go to the anesthetic recovery room without requiring hospital admission. The degree of satisfaction of the quality of the service and the care that must be completed before discharge and after surgery will be recorded.&#xD;
1 phone review call will be made per month +/- 30 days in order to assess the safety and satisfaction of the procedure.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Hospitalization appendectomy</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Patients with acute uncomplicated appendicitis that require emergency appendectomy. The intervention will be the classic.Once the appendectomy is performed, all the selection criteria will be reassessed and the definitive inclusion of the patients will be performed.&#xD;
Patients after surgery will go to the anesthetic recovery room and then be admitted to hospital beds, to be discharged within approximately 12 hours.&#xD;
1 phone review call will be made per month +/- 30 days in order to assess the safety and satisfaction of the procedure.</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Outpatient (OA)</intervention_name>
    <description>Patients who are candidates for OA and therefore pre-selected based on the primary data and characteristics of the clinical signs, will be admitted to the surgical observation in charge of our service. The patient will be informed in detail of the intervention to be performed and discharge on an outpatient basis and will sign the informed consent understanding and thus accepting all the information. The patient will undergo surgery using a laparoscopic or open technique with minimal incision.&#xD;
Once the appendectomy is performed, all the selection criteria will be reassessed and the definitive inclusion of the patients will be performed. In this case, we will perform the blind randomization of the patients. If all the inclusion requirements for the study are met, and the patient belongs to the OA group (case group), he will be discharged on an outpatient basis from the post-surgical stay unit without requiring hospital admission.</description>
    <arm_group_label>Outpatient appendectomy</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Hospitalization appendectomy (HA)</intervention_name>
    <description>Patients who are candidates for HA and therefore pre-selected based on the primary data and characteristics of the clinical signs, will be admitted to the surgical observation in charge of our service. The patient will be informed in detail of the intervention to be performed and discharge on an outpatient basis and will sign the informed consent understanding and thus accepting all the information. The patient will undergo surgery using a laparoscopic or open technique with minimal incision.&#xD;
Once the appendectomy is performed, all the selection criteria will be reassessed and the definitive inclusion of the patients will be performed. In this case, we will perform the blind randomization of the patients. If all the inclusion requirements for the study are met, and the patient belongs to the case group (HA), he will be admitted in hospital beds.</description>
    <arm_group_label>Hospitalization appendectomy</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patients over 14 years of age and who provide informed consent to participate in the&#xD;
             study.&#xD;
&#xD;
          -  Patients with non complicated acute appendicitis requiring and urgent appendectomy&#xD;
             (laparoscopic or minimum incision)&#xD;
&#xD;
          -  Negative appendicectomy.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Complicated acute appendicitis (abscess, perforated, necrosis and peritonitis)&#xD;
&#xD;
          -  Need to place intraoperative drainage.&#xD;
&#xD;
          -  Patients with American Society of Anesthesiologists (ASA) &gt;IV.&#xD;
&#xD;
          -  Immunosuppressed patients.&#xD;
&#xD;
          -  Pregnant.&#xD;
&#xD;
          -  Possibility of inflammatory bowel disease.&#xD;
&#xD;
          -  No family support.&#xD;
&#xD;
          -  No informed consent signature.&#xD;
&#xD;
          -  Impossibility to comply with the established follow-up&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>14 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Pareja C Felipe, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Padillo R Javier, PhD</last_name>
    <role>Study Director</role>
    <affiliation>HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Durán MC Virginia María, MD</last_name>
    <role>Study Chair</role>
    <affiliation>HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Pareja C Felipe, PhD</last_name>
    <phone>+34630962443</phone>
    <email>felipe.pareja67@gmail.com</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Durán MC Virginia María, MD</last_name>
    <phone>+34630962443</phone>
    <email>virginia.dm.87@gmail.com</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Hospital Universitario Virgen Del Rocio</name>
      <address>
        <city>Sevilla</city>
        <zip>41013</zip>
        <country>Spain</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Pareja C Felipe, PhD</last_name>
      <phone>+34630962443</phone>
      <email>felipe.pareja67@gmail.com</email>
    </contact>
    <contact_backup>
      <last_name>Durán MC Virginia, MD</last_name>
      <phone>+34620073024</phone>
      <email>virginia.dm.87@gmail.com</email>
    </contact_backup>
  </location>
  <location_countries>
    <country>Spain</country>
  </location_countries>
  <reference>
    <citation>Di Saverio S, Birindelli A, Kelly MD, Catena F, Weber DG, Sartelli M, Sugrue M, De Moya M, Gomes CA, Bhangu A, Agresta F, Moore EE, Soreide K, Griffiths E, De Castro S, Kashuk J, Kluger Y, Leppaniemi A, Ansaloni L, Andersson M, Coccolini F, Coimbra R, Gurusamy KS, Campanile FC, Biffl W, Chiara O, Moore F, Peitzman AB, Fraga GP, Costa D, Maier RV, Rizoli S, Balogh ZJ, Bendinelli C, Cirocchi R, Tonini V, Piccinini A, Tugnoli G, Jovine E, Persiani R, Biondi A, Scalea T, Stahel P, Ivatury R, Velmahos G, Andersson R. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis. World J Emerg Surg. 2016 Jul 18;11:34. doi: 10.1186/s13017-016-0090-5. eCollection 2016.</citation>
    <PMID>27437029</PMID>
  </reference>
  <reference>
    <citation>Cash CL, Frazee RC, Abernathy SW, Childs EW, Davis ML, Hendricks JC, Smith RW. A prospective treatment protocol for outpatient laparoscopic appendectomy for acute appendicitis. J Am Coll Surg. 2012 Jul;215(1):101-5; discussion 105-6. doi: 10.1016/j.jamcollsurg.2012.02.024. Epub 2012 May 19.</citation>
    <PMID>22609030</PMID>
  </reference>
  <reference>
    <citation>Aguayo P, Alemayehu H, Desai AA, Fraser JD, St Peter SD. Initial experience with same day discharge after laparoscopic appendectomy for nonperforated appendicitis. J Surg Res. 2014 Jul;190(1):93-7. doi: 10.1016/j.jss.2014.03.012. Epub 2014 Mar 12.</citation>
    <PMID>24725679</PMID>
  </reference>
  <reference>
    <citation>Frazee RC, Abernathy SW, Isbell CL, Isbell T, Regner JL, Smith RD. Outpatient Laparoscopic Appendectomy: Is It Time to End the Discussion? J Am Coll Surg. 2016 Apr;222(4):473-7. doi: 10.1016/j.jamcollsurg.2015.12.053. Epub 2016 Jan 14.</citation>
    <PMID>26920990</PMID>
  </reference>
  <reference>
    <citation>Frazee R, Burlew CC, Regner J, McIntyre R, Peltz E, Cribari C, Dunn J, Butler L, Reckard P, Dissanaike S, Karimi K, Behnfield C, Melo N, Margulies D. Discussion of: &quot;Outpatient laparoscopic appendectomy can be successfully performed for uncomplicated appendicitis: A Southwestern Surgical Congress multicenter trial&quot;. Am J Surg. 2017 Dec;214(6):1010-1011. doi: 10.1016/j.amjsurg.2017.10.003. Epub 2017 Oct 5. No abstract available.</citation>
    <PMID>29079020</PMID>
  </reference>
  <reference>
    <citation>Trejo-Avila M, Cardenas-Lailson E, Valenzuela-Salazar C, Herrera-Esquivel J, Moreno-Portillo M. Ambulatory versus conventional laparoscopic appendectomy: a systematic review and meta-analysis. Int J Colorectal Dis. 2019 Aug;34(8):1359-1368. doi: 10.1007/s00384-019-03341-y. Epub 2019 Jul 5.</citation>
    <PMID>31273450</PMID>
  </reference>
  <verification_date>July 2020</verification_date>
  <study_first_submitted>February 11, 2020</study_first_submitted>
  <study_first_submitted_qc>July 6, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 9, 2020</study_first_posted>
  <last_update_submitted>January 12, 2021</last_update_submitted>
  <last_update_submitted_qc>January 12, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">January 13, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Appendicitis</mesh_term>
  </condition_browse>
  <provided_document_section>
    <provided_document>
      <document_type>Informed Consent Form</document_type>
      <document_has_protocol>No</document_has_protocol>
      <document_has_icf>Yes</document_has_icf>
      <document_has_sap>No</document_has_sap>
      <document_date>January 16, 2019</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/82/NCT04464382/ICF_000.pdf</document_url>
    </provided_document>
  </provided_document_section>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04464382
org study id: PENDI_CSI
nct id: NCT04464382
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
This study evaluates the Safety and Efficacy of a outpatient appendectomy. Half of
      participants will be perform the hospitalization, while the other half will undergo the
      outpatient appendectomy
Acute appendicitis (AA) is one of the most common causes of acute abdomen and one of the most
      frequent diagnoses that require urgent surgery worldwide.

      Many laparoscopic procedures are currently performed on an outpatient basis.Laparoscopic
      appendectomy, however, continues to require postoperative hospitalization averaging between 1
      and 2 days, at most institutions.

      At present ambulatory laparoscopic appendectomy (LA) are gained popularity due to the
      improved understanding of patient selection criteria, the application of enhanced recovery
      pathways, and the potential for improving healthcare resource utilization.

      There are few studies about to compare the morbidity and readmission rates between ambulatory
      and conventional LA.

      There is a lack of high-quality comparative studies making conclusive recommendations not
      possible at this time. Based on current data, ambulatory LA may be safe and feasible as
      compared with conventional LA.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Health Services Research
masking: Double (Participant, Investigator)
measure: Rates of ambulatory appendectomy patients that have ambulatory surgery
time frame: 20 months
description: Analyze morbidity of appendectomy patients to determine the safety of ambulatory surgery
measure: Rates of readmission of appendectomy patients that had ambulatory surgery
time frame: 20 months
description: Analyze rates of readmission of appendectomy patients to determine the safety of ambulatory surgery
measure: Prevalence of ambulatory appendectomy patients
time frame: 20 months
description: Measure the percentage of ambulatory surgery and uncomplicated acute appendicitis vs the percentage of ambulatory surgery in failure patients with the same pathology e.g.
Uncontrolled abdominal pain with analgesia.
Upper airway discomfort related to intubation that is not controlled with medication.
Pain in the back or shoulders in relation to the pneumoperitoneum that are in patients with not controlled with the medication.
Hemodynamically abnormal. Uncontrolled bleeding at the level of any of the wounds. Need for reoperation. Need to re-enter or consult the Emergency Service No spontaneous urination.
Nausea / vomiting.
Oral intolerance.
No wandering.
Insecurity or fear of the patient at discharge.
measure: Media of time until the total incorporation to the activities of the daily life after appendectomy
time frame: 20 months
description: To value the time until the total incorporation to the activities of the daily life after appendectomy.
measure: Rates of satisfaction
time frame: 20 months
description: Measure the degree of satisfaction of our patients with outpatient management after appendectomy, using a satisfaction questionnaire.
measure: Costs of the outpatient regimen versus the hospitalization of patients
time frame: 20 months
description: Compare the costs of the outpatient regimen versus the hospitalization of patients with uncomplicated acute appendicitis (cost-minimization analysis).
arm group label: Outpatient appendectomy
arm group type: Experimental
description: Patients with acute uncomplicated appendicitis that require emergency appendectomy. The intervention will be the classic.Once the appendectomy is performed, all the selection criteria will be reassessed and the definitive inclusion of the patients will be performed.
Patients after surgery will go to the anesthetic recovery room without requiring hospital admission. The degree of satisfaction of the quality of the service and the care that must be completed before discharge and after surgery will be recorded.
1 phone review call will be made per month +/- 30 days in order to assess the safety and satisfaction of the procedure.
arm group label: Hospitalization appendectomy
arm group type: Active Comparator
description: Patients with acute uncomplicated appendicitis that require emergency appendectomy. The intervention will be the classic.Once the appendectomy is performed, all the selection criteria will be reassessed and the definitive inclusion of the patients will be performed.
Patients after surgery will go to the anesthetic recovery room and then be admitted to hospital beds, to be discharged within approximately 12 hours.
1 phone review call will be made per month +/- 30 days in order to assess the safety and satisfaction of the procedure.
intervention type: Procedure
intervention name: Outpatient (OA)
description: Patients who are candidates for OA and therefore pre-selected based on the primary data and characteristics of the clinical signs, will be admitted to the surgical observation in charge of our service. The patient will be informed in detail of the intervention to be performed and discharge on an outpatient basis and will sign the informed consent understanding and thus accepting all the information. The patient will undergo surgery using a laparoscopic or open technique with minimal incision.
Once the appendectomy is performed, all the selection criteria will be reassessed and the definitive inclusion of the patients will be performed. In this case, we will perform the blind randomization of the patients. If all the inclusion requirements for the study are met, and the patient belongs to the OA group (case group), he will be discharged on an outpatient basis from the post-surgical stay unit without requiring hospital admission.
arm group label: Outpatient appendectomy
intervention type: Procedure
intervention name: Hospitalization appendectomy (HA)
description: Patients who are candidates for HA and therefore pre-selected based on the primary data and characteristics of the clinical signs, will be admitted to the surgical observation in charge of our service. The patient will be informed in detail of the intervention to be performed and discharge on an outpatient basis and will sign the informed consent understanding and thus accepting all the information. The patient will undergo surgery using a laparoscopic or open technique with minimal incision.
Once the appendectomy is performed, all the selection criteria will be reassessed and the definitive inclusion of the patients will be performed. In this case, we will perform the blind randomization of the patients. If all the inclusion requirements for the study are met, and the patient belongs to the case group (HA), he will be admitted in hospital beds.
arm group label: Hospitalization appendectomy
criteria: 
gender: All
minimum age: 14 Years
maximum age: N/A
healthy volunteers: No
last name: Pareja C Felipe, PhD
role: Principal Investigator
affiliation: HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO
last name: Padillo R Javier, PhD
role: Study Director
affiliation: HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO
last name: Durán MC Virginia María, MD
role: Study Chair
affiliation: HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO
last name: Pareja C Felipe, PhD
phone: +34630962443
email: felipe.pareja67@gmail.com
last name: Durán MC Virginia María, MD
phone: +34630962443
email: virginia.dm.87@gmail.com
facility: 
status: Recruiting
contact: 
contact backup: 
country: Spain
citation: Di Saverio S, Birindelli A, Kelly MD, Catena F, Weber DG, Sartelli M, Sugrue M, De Moya M, Gomes CA, Bhangu A, Agresta F, Moore EE, Soreide K, Griffiths E, De Castro S, Kashuk J, Kluger Y, Leppaniemi A, Ansaloni L, Andersson M, Coccolini F, Coimbra R, Gurusamy KS, Campanile FC, Biffl W, Chiara O, Moore F, Peitzman AB, Fraga GP, Costa D, Maier RV, Rizoli S, Balogh ZJ, Bendinelli C, Cirocchi R, Tonini V, Piccinini A, Tugnoli G, Jovine E, Persiani R, Biondi A, Scalea T, Stahel P, Ivatury R, Velmahos G, Andersson R. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis. World J Emerg Surg. 2016 Jul 18;11:34. doi: 10.1186/s13017-016-0090-5. eCollection 2016.
PMID: 27437029
citation: Cash CL, Frazee RC, Abernathy SW, Childs EW, Davis ML, Hendricks JC, Smith RW. A prospective treatment protocol for outpatient laparoscopic appendectomy for acute appendicitis. J Am Coll Surg. 2012 Jul;215(1):101-5; discussion 105-6. doi: 10.1016/j.jamcollsurg.2012.02.024. Epub 2012 May 19.
PMID: 22609030
citation: Aguayo P, Alemayehu H, Desai AA, Fraser JD, St Peter SD. Initial experience with same day discharge after laparoscopic appendectomy for nonperforated appendicitis. J Surg Res. 2014 Jul;190(1):93-7. doi: 10.1016/j.jss.2014.03.012. Epub 2014 Mar 12.
PMID: 24725679
citation: Frazee RC, Abernathy SW, Isbell CL, Isbell T, Regner JL, Smith RD. Outpatient Laparoscopic Appendectomy: Is It Time to End the Discussion? J Am Coll Surg. 2016 Apr;222(4):473-7. doi: 10.1016/j.jamcollsurg.2015.12.053. Epub 2016 Jan 14.
PMID: 26920990
citation: Frazee R, Burlew CC, Regner J, McIntyre R, Peltz E, Cribari C, Dunn J, Butler L, Reckard P, Dissanaike S, Karimi K, Behnfield C, Melo N, Margulies D. Discussion of: "Outpatient laparoscopic appendectomy can be successfully performed for uncomplicated appendicitis: A Southwestern Surgical Congress multicenter trial". Am J Surg. 2017 Dec;214(6):1010-1011. doi: 10.1016/j.amjsurg.2017.10.003. Epub 2017 Oct 5. No abstract available.
PMID: 29079020
citation: Trejo-Avila M, Cardenas-Lailson E, Valenzuela-Salazar C, Herrera-Esquivel J, Moreno-Portillo M. Ambulatory versus conventional laparoscopic appendectomy: a systematic review and meta-analysis. Int J Colorectal Dis. 2019 Aug;34(8):1359-1368. doi: 10.1007/s00384-019-03341-y. Epub 2019 Jul 5.
PMID: 31273450
responsible party type: Sponsor
mesh term: Appendicitis
provided document: 