<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04425590</url>
  </required_header>
  <id_info>
    <org_study_id>INADLBS</org_study_id>
    <nct_id>NCT04425590</nct_id>
  </id_info>
  <brief_title>The Benefit of Add On DLBS1033 for Ischemic Stroke Patient</brief_title>
  <official_title>The Role of DLBS1033 in the Management of Acute Ischemic Stroke Patients: Study Protocol for a Randomized Controlled Study</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Duta Wacana Christian University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Dexa Laboratories Of Biomolecular Science</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Duta Wacana Christian University</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Stroke is one of the most common non-communicable diseases worldwide. It is the leading cause&#xD;
      of morbidity and mortality in many countries.&#xD;
&#xD;
      Stroke is broadly classified into ischemic and hemorrhagic stroke. Ischemic stroke is more&#xD;
      common than hemorrhagic stroke. In Indonesia, the prevalence of ischemic stroke is 42.9%&#xD;
      compare to hemorrhagic stroke 19.9%. Ischemic stroke defined as an episode of neurological&#xD;
      dysfunction caused by focal cerebral, spinal, or retinal infarction.&#xD;
&#xD;
      One of the main therapy in ischemic stroke is administration of anti thrombotic agent.&#xD;
      DLBS1033 is a bioactive protein fraction isolated from Lumbricus rubellus. DLBS1033 possessed&#xD;
      quadruple activities that inhibit platelet aggregation, induces fibrinogenolysis,&#xD;
      fibrinolysis, and thrombolysis. This is a new proposed medication nowadays. There is still a&#xD;
      limited study about DLBS1033. To our knowledge, research concern on the usage of DLBS1033 in&#xD;
      stroke patients is very limited in Indonesia. This study aimed to Measure the benefit of&#xD;
      DLBS1033 as add on therapy for ischemic stroke patients.&#xD;
&#xD;
      The hypothesis of this study :&#xD;
&#xD;
      a. The use of DLBS1033 improve functional status of ischemic stroke patients at hospital&#xD;
      discharge. b. The use of DLBS1033 improve functional status 30-days after stroke onset.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      This was randomized, controlled, open-label, study from the period of April 2020 - August&#xD;
      2020 at Bethesda Hospital, Yogyakarta, Indonesia.&#xD;
&#xD;
      There were 180 acute ischemic stroke patients who fulfilled the inclusion and exclusion&#xD;
      criteria. Each subject recruited from acute stroke intensive care unit had been followed up&#xD;
      from the first day they were hospitalized until hospital discharge (died or discharged alive)&#xD;
      and 30 days after the onset.&#xD;
&#xD;
      Ethical approval number 1087/C.16/FK/2019 was obtained from Health Research Ethics Committee,&#xD;
      Faculty of Medicine Duta Wacana Christian University Yogyakarta. This research has been&#xD;
      registered at Center for Health Resources and Services Research and Development Indonesia&#xD;
      with the ethical approval number of 1087/C.16/FK/2019.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">April 1, 2020</start_date>
  <completion_date type="Anticipated">August 2020</completion_date>
  <primary_completion_date type="Anticipated">August 2020</primary_completion_date>
  <phase>Phase 2/Phase 3</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>Eligible subjects were randomly allocated to receive any of the following regiments: standard therapy consists of aspirin 100 mg once daily, atorvastatin 20 mg once daily, vitamin B12 100 mg three times daily (control group) or standard therapy and DLBS1033 3 times daily (experimental group).</intervention_model_description>
    <primary_purpose>Supportive Care</primary_purpose>
    <masking>None (Open Label)</masking>
    <masking_description>Open label</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Improvement in modified Rankin Scale (mRS) scores at hospital discharge</measure>
    <time_frame>At hospital discharge (approximately 4 days after treatment initiation)</time_frame>
    <description>Change in functional outcomes as measured by Modified Rankin Scale (MRS) from its baseline value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Improvement in modified Rankin Scale (mRS) scores at 30 days</measure>
    <time_frame>30 days after treatment initiation</time_frame>
    <description>Change in functional outcomes as measured by Modified Rankin Scale (MRS) from its hospital discharge value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Improvement in National Institutes of Health Stroke Scale (NIHSS) scores at hospital discharge</measure>
    <time_frame>At hospital discharge (approximately 4 days after treatment initiation)</time_frame>
    <description>Change in functional outcomes as measured by National Institutes of Health Stroke Scale (NIHSS) from its baseline value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Improvement in National Institutes of Health Stroke Scale (NIHSS) scores at 30 days</measure>
    <time_frame>30 days after treatment initiation</time_frame>
    <description>Change in functional outcomes as measured by National Institutes of Health Stroke Scale (NIHSS) from its hospital discharge value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Improvement in Barthel Index (BI) scores at hospital discharge</measure>
    <time_frame>At hospital discharge (approximately 4 days after treatment initiation)</time_frame>
    <description>Change in functional outcomes as measured by Barthel Index (BI) from its baseline value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Improvement in Barthel Index (BI) scores at 30 days</measure>
    <time_frame>30 days after treatment initiation</time_frame>
    <description>Change in functional outcomes as measured by Barthel Index (BI) from its hospital discharge value.</description>
  </primary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">180</enrollment>
  <condition>Ischemic Stroke</condition>
  <arm_group>
    <arm_group_label>Experimental Group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>standard therapy consists of aspirin 100 mg once daily, atorvastatin 20 mg once daily, vitamin B12 100 mg three times daily and DLBS1033 3 times daily (experimental group).</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Control Group</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>standard therapy consists of aspirin 100 mg once daily, atorvastatin 20 mg once daily, vitamin B12 100 mg three times daily</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>DLBS1033</intervention_name>
    <description>DLBS 1033 490 mg tablet 3 times daily</description>
    <arm_group_label>Experimental Group</arm_group_label>
    <other_name>Disolf</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Aspirin</intervention_name>
    <description>Aspirin 100 mg tablet once daily</description>
    <arm_group_label>Control Group</arm_group_label>
    <arm_group_label>Experimental Group</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Statin</intervention_name>
    <description>Atorvastatin 20 mg tablet once daily</description>
    <arm_group_label>Control Group</arm_group_label>
    <arm_group_label>Experimental Group</arm_group_label>
    <other_name>Atorvastatin</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Vit B12</intervention_name>
    <description>Vit B12 100 mg tablet three times daily</description>
    <arm_group_label>Control Group</arm_group_label>
    <arm_group_label>Experimental Group</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Male or female&#xD;
&#xD;
          -  Adult age (&gt;18 years old)&#xD;
&#xD;
          -  Diagnosed with acute ischemic stroke for the first time&#xD;
&#xD;
          -  The onset is &lt;24 hours&#xD;
&#xD;
          -  Not a referral patient&#xD;
&#xD;
          -  GCS score of 15 (fully alert)&#xD;
&#xD;
          -  Mild to moderate scores on NIHSS&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Subjects known to have hypersensitivity to DLBS1033&#xD;
&#xD;
          -  Participated in other studies for the past 1 month&#xD;
&#xD;
          -  Not competent enough in giving approval and answering questionnaires&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Rizaldy Pinzon, MD, MSc, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Duta Wacana Christian University</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Rizaldy T Pinzon, MD, MSc, PhD</last_name>
    <phone>+62 81294638229</phone>
    <email>drpinzon17@gmail.com</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Vanessa Veronica</last_name>
    <phone>+62 89605559529</phone>
    <email>vanessaveronica73@gmail.com</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Bethesda Hospital Yogyakarta</name>
      <address>
        <city>Yogyakarta</city>
        <state>Special Region Of Yogyakarta</state>
        <zip>55224</zip>
        <country>Indonesia</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Rizaldy T Pinzon, MD, MSc, PhD</last_name>
      <phone>+62 81294638229</phone>
      <email>drpinzon17@gmail.com</email>
    </contact>
  </location>
  <location_countries>
    <country>Indonesia</country>
  </location_countries>
  <reference>
    <citation>Krishnamurthi RV, Feigin VL, Forouzanfar MH, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson LM, Truelsen T, O'Donnell M, Venketasubramanian N, Barker-Collo S, Lawes CM, Wang W, Shinohara Y, Witt E, Ezzati M, Naghavi M, Murray C; Global Burden of Diseases, Injuries, Risk Factors Study 2010 (GBD 2010); GBD Stroke Experts Group. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet Glob Health. 2013 Nov;1(5):e259-81. doi: 10.1016/S2214-109X(13)70089-5. Epub 2013 Oct 24.</citation>
    <PMID>25104492</PMID>
  </reference>
  <reference>
    <citation>Mellor RM, Bailey S, Sheppard J, Carr P, Quinn T, Boyal A, Sandler D, Sims DG, Mant J, Greenfield S, McManus RJ. Decisions and delays within stroke patients' route to the hospital: a qualitative study. Ann Emerg Med. 2015 Mar;65(3):279-287.e3. doi: 10.1016/j.annemergmed.2014.10.018. Epub 2014 Nov 15.</citation>
    <PMID>25455907</PMID>
  </reference>
  <reference>
    <citation>Ogbole GI, Owolabi MO, Ogun O, Ogunseyinde OA, Ogunniyi A. TIME OF PRESENTATION OF STROKE PATIENTS FOR CT IMAGING IN A NIGERIAN TERTIARY HOSPITAL. Ann Ib Postgrad Med. 2015 Jun;13(1):23-8.</citation>
    <PMID>26807083</PMID>
  </reference>
  <reference>
    <citation>Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013 Jul;44(7):2064-89. doi: 10.1161/STR.0b013e318296aeca. Epub 2013 May 7. Erratum In: Stroke. 2019 Aug;50(8):e239.</citation>
    <PMID>23652265</PMID>
  </reference>
  <reference>
    <citation>Tjandrawinata RR, Trisina J, Rahayu P, Prasetya LA, Hanafiah A, Rachmawati H. Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies. Drug Des Devel Ther. 2014 Sep 25;8:1585-93. doi: 10.2147/DDDT.S66007. eCollection 2014.</citation>
    <PMID>25284988</PMID>
  </reference>
  <reference>
    <citation>Toyoda K. Epidemiology and registry studies of stroke in Japan. J Stroke. 2013 Jan;15(1):21-6. doi: 10.5853/jos.2013.15.1.21. Epub 2013 Jan 31.</citation>
    <PMID>24324936</PMID>
  </reference>
  <reference>
    <citation>Trisina J, Sunardi F, Suhartono MT, Tjandrawinata RR. DLBS1033, a protein extract from Lumbricus rubellus, possesses antithrombotic and thrombolytic activities. J Biomed Biotechnol. 2011;2011:519652. doi: 10.1155/2011/519652. Epub 2011 Mar 3.</citation>
    <PMID>21403877</PMID>
  </reference>
  <reference>
    <citation>Venketasubramanian N, Yoon BW, Pandian J, Navarro JC. Stroke Epidemiology in South, East, and South-East Asia: A Review. J Stroke. 2017 Sep;19(3):286-294. doi: 10.5853/jos.2017.00234. Epub 2017 Sep 29. Erratum In: J Stroke. 2018 Jan;20(1):142.</citation>
    <PMID>29037005</PMID>
  </reference>
  <reference>
    <citation>Zhou M, Offer A, Yang G, Smith M, Hui G, Whitlock G, Collins R, Huang Z, Peto R, Chen Z. Body mass index, blood pressure, and mortality from stroke: a nationally representative prospective study of 212,000 Chinese men. Stroke. 2008 Mar;39(3):753-9. doi: 10.1161/STROKEAHA.107.495374. Epub 2008 Jan 31.</citation>
    <PMID>18239175</PMID>
  </reference>
  <verification_date>June 2020</verification_date>
  <study_first_submitted>May 27, 2020</study_first_submitted>
  <study_first_submitted_qc>June 7, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 11, 2020</study_first_posted>
  <last_update_submitted>June 7, 2020</last_update_submitted>
  <last_update_submitted_qc>June 7, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">June 11, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Duta Wacana Christian University</investigator_affiliation>
    <investigator_full_name>Rizaldy Taslim Pinzon</investigator_full_name>
    <investigator_title>Principal investigator, Neurologist</investigator_title>
  </responsible_party>
  <keyword>DLBS1033</keyword>
  <keyword>Standard therapy</keyword>
  <keyword>Stroke</keyword>
  <keyword>Outcomes</keyword>
  <keyword>Lumbrokinase</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Stroke</mesh_term>
    <mesh_term>Ischemic Stroke</mesh_term>
    <mesh_term>Cerebral Infarction</mesh_term>
    <mesh_term>Ischemia</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Aspirin</mesh_term>
    <mesh_term>Atorvastatin</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04425590
org study id: INADLBS
nct id: NCT04425590
lead sponsor: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Stroke is one of the most common non-communicable diseases worldwide. It is the leading cause
      of morbidity and mortality in many countries.

      Stroke is broadly classified into ischemic and hemorrhagic stroke. Ischemic stroke is more
      common than hemorrhagic stroke. In Indonesia, the prevalence of ischemic stroke is 42.9%
      compare to hemorrhagic stroke 19.9%. Ischemic stroke defined as an episode of neurological
      dysfunction caused by focal cerebral, spinal, or retinal infarction.

      One of the main therapy in ischemic stroke is administration of anti thrombotic agent.
      DLBS1033 is a bioactive protein fraction isolated from Lumbricus rubellus. DLBS1033 possessed
      quadruple activities that inhibit platelet aggregation, induces fibrinogenolysis,
      fibrinolysis, and thrombolysis. This is a new proposed medication nowadays. There is still a
      limited study about DLBS1033. To our knowledge, research concern on the usage of DLBS1033 in
      stroke patients is very limited in Indonesia. This study aimed to Measure the benefit of
      DLBS1033 as add on therapy for ischemic stroke patients.

      The hypothesis of this study :

      a. The use of DLBS1033 improve functional status of ischemic stroke patients at hospital
      discharge. b. The use of DLBS1033 improve functional status 30-days after stroke onset.
This was randomized, controlled, open-label, study from the period of April 2020 - August
      2020 at Bethesda Hospital, Yogyakarta, Indonesia.

      There were 180 acute ischemic stroke patients who fulfilled the inclusion and exclusion
      criteria. Each subject recruited from acute stroke intensive care unit had been followed up
      from the first day they were hospitalized until hospital discharge (died or discharged alive)
      and 30 days after the onset.

      Ethical approval number 1087/C.16/FK/2019 was obtained from Health Research Ethics Committee,
      Faculty of Medicine Duta Wacana Christian University Yogyakarta. This research has been
      registered at Center for Health Resources and Services Research and Development Indonesia
      with the ethical approval number of 1087/C.16/FK/2019.
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: Eligible subjects were randomly allocated to receive any of the following regiments: standard therapy consists of aspirin 100 mg once daily, atorvastatin 20 mg once daily, vitamin B12 100 mg three times daily (control group) or standard therapy and DLBS1033 3 times daily (experimental group).
primary purpose: Supportive Care
masking: None (Open Label)
masking description: Open label
measure: Improvement in modified Rankin Scale (mRS) scores at hospital discharge
time frame: At hospital discharge (approximately 4 days after treatment initiation)
description: Change in functional outcomes as measured by Modified Rankin Scale (MRS) from its baseline value.
measure: Improvement in modified Rankin Scale (mRS) scores at 30 days
time frame: 30 days after treatment initiation
description: Change in functional outcomes as measured by Modified Rankin Scale (MRS) from its hospital discharge value.
measure: Improvement in National Institutes of Health Stroke Scale (NIHSS) scores at hospital discharge
time frame: At hospital discharge (approximately 4 days after treatment initiation)
description: Change in functional outcomes as measured by National Institutes of Health Stroke Scale (NIHSS) from its baseline value.
measure: Improvement in National Institutes of Health Stroke Scale (NIHSS) scores at 30 days
time frame: 30 days after treatment initiation
description: Change in functional outcomes as measured by National Institutes of Health Stroke Scale (NIHSS) from its hospital discharge value.
measure: Improvement in Barthel Index (BI) scores at hospital discharge
time frame: At hospital discharge (approximately 4 days after treatment initiation)
description: Change in functional outcomes as measured by Barthel Index (BI) from its baseline value.
measure: Improvement in Barthel Index (BI) scores at 30 days
time frame: 30 days after treatment initiation
description: Change in functional outcomes as measured by Barthel Index (BI) from its hospital discharge value.
arm group label: Experimental Group
arm group type: Experimental
description: standard therapy consists of aspirin 100 mg once daily, atorvastatin 20 mg once daily, vitamin B12 100 mg three times daily and DLBS1033 3 times daily (experimental group).
arm group label: Control Group
arm group type: Active Comparator
description: standard therapy consists of aspirin 100 mg once daily, atorvastatin 20 mg once daily, vitamin B12 100 mg three times daily
intervention type: Drug
intervention name: DLBS1033
description: DLBS 1033 490 mg tablet 3 times daily
arm group label: Experimental Group
other name: Disolf
intervention type: Drug
intervention name: Aspirin
description: Aspirin 100 mg tablet once daily
arm group label: Control Group
arm group label: Experimental Group
intervention type: Drug
intervention name: Statin
description: Atorvastatin 20 mg tablet once daily
arm group label: Control Group
arm group label: Experimental Group
other name: Atorvastatin
intervention type: Drug
intervention name: Vit B12
description: Vit B12 100 mg tablet three times daily
arm group label: Control Group
arm group label: Experimental Group
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Rizaldy Pinzon, MD, MSc, PhD
role: Principal Investigator
affiliation: Duta Wacana Christian University
last name: Rizaldy T Pinzon, MD, MSc, PhD
phone: +62 81294638229
email: drpinzon17@gmail.com
last name: Vanessa Veronica
phone: +62 89605559529
email: vanessaveronica73@gmail.com
facility: 
status: Recruiting
contact: 
country: Indonesia
citation: Krishnamurthi RV, Feigin VL, Forouzanfar MH, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson LM, Truelsen T, O'Donnell M, Venketasubramanian N, Barker-Collo S, Lawes CM, Wang W, Shinohara Y, Witt E, Ezzati M, Naghavi M, Murray C; Global Burden of Diseases, Injuries, Risk Factors Study 2010 (GBD 2010); GBD Stroke Experts Group. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet Glob Health. 2013 Nov;1(5):e259-81. doi: 10.1016/S2214-109X(13)70089-5. Epub 2013 Oct 24.
PMID: 25104492
citation: Mellor RM, Bailey S, Sheppard J, Carr P, Quinn T, Boyal A, Sandler D, Sims DG, Mant J, Greenfield S, McManus RJ. Decisions and delays within stroke patients' route to the hospital: a qualitative study. Ann Emerg Med. 2015 Mar;65(3):279-287.e3. doi: 10.1016/j.annemergmed.2014.10.018. Epub 2014 Nov 15.
PMID: 25455907
citation: Ogbole GI, Owolabi MO, Ogun O, Ogunseyinde OA, Ogunniyi A. TIME OF PRESENTATION OF STROKE PATIENTS FOR CT IMAGING IN A NIGERIAN TERTIARY HOSPITAL. Ann Ib Postgrad Med. 2015 Jun;13(1):23-8.
PMID: 26807083
citation: Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013 Jul;44(7):2064-89. doi: 10.1161/STR.0b013e318296aeca. Epub 2013 May 7. Erratum In: Stroke. 2019 Aug;50(8):e239.
PMID: 23652265
citation: Tjandrawinata RR, Trisina J, Rahayu P, Prasetya LA, Hanafiah A, Rachmawati H. Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies. Drug Des Devel Ther. 2014 Sep 25;8:1585-93. doi: 10.2147/DDDT.S66007. eCollection 2014.
PMID: 25284988
citation: Toyoda K. Epidemiology and registry studies of stroke in Japan. J Stroke. 2013 Jan;15(1):21-6. doi: 10.5853/jos.2013.15.1.21. Epub 2013 Jan 31.
PMID: 24324936
citation: Trisina J, Sunardi F, Suhartono MT, Tjandrawinata RR. DLBS1033, a protein extract from Lumbricus rubellus, possesses antithrombotic and thrombolytic activities. J Biomed Biotechnol. 2011;2011:519652. doi: 10.1155/2011/519652. Epub 2011 Mar 3.
PMID: 21403877
citation: Venketasubramanian N, Yoon BW, Pandian J, Navarro JC. Stroke Epidemiology in South, East, and South-East Asia: A Review. J Stroke. 2017 Sep;19(3):286-294. doi: 10.5853/jos.2017.00234. Epub 2017 Sep 29. Erratum In: J Stroke. 2018 Jan;20(1):142.
PMID: 29037005
citation: Zhou M, Offer A, Yang G, Smith M, Hui G, Whitlock G, Collins R, Huang Z, Peto R, Chen Z. Body mass index, blood pressure, and mortality from stroke: a nationally representative prospective study of 212,000 Chinese men. Stroke. 2008 Mar;39(3):753-9. doi: 10.1161/STROKEAHA.107.495374. Epub 2008 Jan 31.
PMID: 18239175
responsible party type: Principal Investigator
investigator affiliation: Duta Wacana Christian University
investigator full name: Rizaldy Taslim Pinzon
investigator title: Principal investigator, Neurologist
mesh term: Stroke
mesh term: Ischemic Stroke
mesh term: Cerebral Infarction
mesh term: Ischemia
mesh term: Aspirin
mesh term: Atorvastatin
sharing ipd: No