<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04425616</url>
  </required_header>
  <id_info>
    <org_study_id>RHM CRI 0403</org_study_id>
    <nct_id>NCT04425616</nct_id>
  </id_info>
  <brief_title>SafeFit Trial: Virtual Clinics to Deliver Universal Interventions in People With Cancer</brief_title>
  <official_title>SafeFit Trial: Virtual Clinics to Deliver Universal Interventions to Maintain and Improve Mental and Physical Health in People With Cancer Who Are Following Social Distancing Guidance: A COVID-19 Targeted Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University Hospital Southampton NHS Foundation Trust</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Macmillan Cancer Support</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>CanRehab Trust</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Wessex Cancer Alliance</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>University Hospital Southampton NHS Foundation Trust</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Trial Phase: Phase III: Interventional Trial: Virtual clinics to deliver universal&#xD;
      interventions to maintain and improve physical health, nutritional state and psychological&#xD;
      wellbeing in people with cancer who are following social distancing guidance: A COVID-19&#xD;
      targeted trial.&#xD;
&#xD;
      Indication: Male or female participants, aged over 18 years old with suspicion or confirmed&#xD;
      diagnosis of cancer (does not require histological confirmation)&#xD;
&#xD;
      Objective: To investigate the efficacy of remote multimodal universal interventions delivered&#xD;
      via virtual clinics to improve physical function as measured by the EORTC-QLQ-C30.&#xD;
&#xD;
      Secondary Objective:&#xD;
&#xD;
      To investigate the efficacy of remote multimodal universal interventions delivered via&#xD;
      virtual clinics to improve emotional function, quality of life, participant activation (PAM),&#xD;
      behaviour change and the effect it has on health economics (EQ-5D-5L).&#xD;
&#xD;
      Exploratory Objective:&#xD;
&#xD;
      Overall Survival and adherence to the intervention/advice using validated tools or&#xD;
      development of a web-based toolkit.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Rationale: A recent statement by Professor Chris Whitty, Chief Medical Officer, NHS England,&#xD;
      emphasised the significant benefits of exercise for all people. He said, &quot;this may be&#xD;
      challenging for people self-isolating and even more so for those highly vulnerable people&#xD;
      that are having to shield against the virus in their own homes&quot; The coronavirus (COVID-19)&#xD;
      pandemic has led to many changes to everyday life including the introduction of social&#xD;
      distancing as well as restriction of travel. Treatment plans for patients with cancer are&#xD;
      being revised or modified due to risks and benefits of certain treatments in light of the&#xD;
      COVID-19 risk. The number of deaths due to the disruption in cancer services is likely to&#xD;
      outweigh the number of deaths from coronavirus itself over the next five years.&#xD;
&#xD;
      The effects of this pandemic has reportedly led to increased anxiety and distress and risks&#xD;
      deconditioning due to reduced physical activity. The interventions we are proposing aim to&#xD;
      enable people with cancer to optimise their physical health, nutritional state and&#xD;
      psychological wellbeing and prepare for their treatment pathway (current or modified) and&#xD;
      recovery during this uncertain time through exercise, nutrition and psychological support.&#xD;
&#xD;
      The aim is to investigate whether the promotion of these interventions delivered via virtual&#xD;
      clinics, in socially distanced people with cancer, can improve physical and psychological&#xD;
      function and self-efficacy to self-manage. We are also aiming to evaluate health economics&#xD;
      whilst following the COVID-19 government guidelines.&#xD;
&#xD;
      Trial Design: Phase III: Non randomised Interventional Trial&#xD;
&#xD;
      Sample Size: 1100&#xD;
&#xD;
      Intervention: Provision of dietary, exercise and psychological advice as well as behaviour&#xD;
      change support (universal interventions) as aligned to the universal interventions (with the&#xD;
      caveats of COVID-19) in the Macmillan 'Principles and guidance for prehabilitation within the&#xD;
      management and support of people with cancer' guideline. This complex intervention will be&#xD;
      prescribed and delivered through virtual clinics where CanRehab professionals will support&#xD;
      the individual. Level 3 Personal Trainers may also deliver the interventions in some cases&#xD;
      with a GP referral qualification and who are competent in delivering the interventions to&#xD;
      participants with cancer post-treatment.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Recruiting</overall_status>
  <start_date type="Actual">June 4, 2020</start_date>
  <completion_date type="Anticipated">December 30, 2023</completion_date>
  <primary_completion_date type="Anticipated">June 30, 2023</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>N/A</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <intervention_model_description>Non-randomised phase III interventional trial</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Physical Function</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>Physical function will be measured using the EORTC-QLQ-C30. Participants will choose from the choices 1 = Not at all; 2 = A little, 3 = Quite a bit, 4 = Very much</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Emotional Function</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>Emotional function will be measured using the EORTC-QLQ-C30. Participants will choose from the choices 1 = Not at all; 2 = A little, 3 = Quite a bit, 4 = Very much</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Health related quality of life</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>EQ-5D-5L is a standardised measure of health status developed by the EuroQol Group. Applicable to a wide range of health conditions and treatments, it provides a simple descriptive profile and a single index value for health status that can be used in the clinical evaluation of health care</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Health economics analysis</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>EQ-5D-5L is a standardised measure of health status developed by the EuroQol Group. Applicable to a wide range of health conditions and treatments, it provides a simple descriptive profile and a single index value for health status that can be used in the economic evaluation of health care</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient activation</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>Patients knowledge skills and confidence to manage their own health and care will be measured using the Patient Activation Measure (PAM)&#xD;
Agreement or disagreement with statements. Choice between disagree strongly, disagree, agree, agree strongly and not applicable</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Self-reported physical activity</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>Measured using the Godin Leisure Time Exercise Questionnaire, a 7-day physical activity recall</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Nutrition assessment</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>In the oncology population where malnutrition prevalence is high, the Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) is a descriptive screening tool that can provide further information to assist triaging and capture acute change in nutritional state</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Self-efficacy for self-management of chronic disease</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>Self-efficacy (confidence) to self-manage chronic disease (SEMCD), measured using the Lorig SEMCD scale&#xD;
A confidence scale that represents the patients confidence that a regular task can be achieved. 1 = Not confident at all and 10= totally confident.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Distress levels</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>Levels of distress as measured by the Emotions Thermometers. Participants will score on a scale where 0 = None and 10 = Extreme</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Functional capacity</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>The Dukes Activity Status Index is a 12 item self-report measure of functional capacity that can be used to estimate peak oxygen uptake</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The impact of COVID-19 pandemic on psychological functioning</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>As measured by the Impact of Event Scale - a 22-item self-report measure of the imapact of a specific traumatic event against the DSM criteria for Post Traumatic Stress Disorder. 0 = Not at all and 4 = Extremely.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Process Evaluation</measure>
    <time_frame>Through study completion, an average of 12 months</time_frame>
    <description>Semi-structured interviews with participants and professionals to explore acceptability, usefulness and barriers to delivery/engagement</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Exploratory: Overall survival</measure>
    <time_frame>1 year post enrolment</time_frame>
    <description>Overall survival at 1 year following date of enrolment</description>
  </other_outcome>
  <other_outcome>
    <measure>Exploratory: Adherence to the interventions/advice</measure>
    <time_frame>Baseline up to 1 year post enrolment</time_frame>
    <description>Adherence to intervention advice is defined as number of sessions the participants attends divided by the total number of sessions.</description>
  </other_outcome>
  <number_of_arms>1</number_of_arms>
  <enrollment type="Anticipated">1100</enrollment>
  <condition>Cancer</condition>
  <condition>COVID</condition>
  <arm_group>
    <arm_group_label>Universal Interventions</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>The delivery of nutrition, exercise and psychological interventions delivered in the following structure:&#xD;
Month 1: Up to three times per week&#xD;
Months 2-3: Once per week&#xD;
Months 4 - 6: One session per month for the last 3 months</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Exercise</intervention_name>
    <description>At least one and up to three supervised sessions per week including:&#xD;
aerobic exercise at a rating of perceived exertion of 11-14 (6-20 scale) accumulating 20 minutes per session&#xD;
resistance exercise of 8-10 exercises for 2x 8-15 repetitions performed in a controlled manner and covering the whole body&#xD;
Range of motion exercise performed through pain free range of motion covering the whole body to be maintained in good alignment for 10-30 seconds, with some movements held for a second set of 10-30 seconds if stiff</description>
    <arm_group_label>Universal Interventions</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Psychological and Behaviour Change Support</intervention_name>
    <description>Instructors will be trained in Healthy Conversation Skills (HCS), Making Every Contact Count (MECC) or equivalent. This will enable them to deliver brief participant centred empowering interventions informed by social cognitive theory. This skill set will be used to support participants in adopting and maintaining the prescribed exercise and diet programme as well as adopting and practicing strategies to self-manage psychological well-being. Participants will be given the option to be provided with a SMARTER goal setting sheet to assist with goal planning. Applicable standardised psychological support resources will be made available to the participants though the Macmillan resource repository that they can access online or in alternative format as necessary, for example relaxation and mindfulness exercises</description>
    <arm_group_label>Universal Interventions</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Nutrition</intervention_name>
    <description>Instructors will receive training in generic nutritional principles in line with recommendations from World Cancer Research Fund (WCRF) and British Dietetic Association, and will work with participant to review own diet and eating habits against WCRF recommendations to enable goal setting and identify links to existing resources reputable websites, outputs and on-line forums. These would include: principles of healthy eating ('eat well' advice), weight management, symptom management, prehab advice before treatment starts, rehab advice during and after treatment. The participant will be asked if they are eating and drinking well or have any concerns at the beginning of each exercise session. Further support will be provided to instructors to address participant concerns or requests for additional information.</description>
    <arm_group_label>Universal Interventions</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Male or female participants, aged over 18 years old&#xD;
&#xD;
          -  Suspicion or confirmed diagnosis of cancer (does not require histological&#xD;
             confirmation)&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
        - Participants unable to give informed consent&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_contact>
    <last_name>Sandy Jack, pHD</last_name>
    <phone>02381205308</phone>
    <email>s.jack@soton.ac.uk</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Samantha Leggett, BSc</last_name>
    <phone>02381208519</phone>
    <email>samantha.leggett@uhs.nhs.uk</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>University Hospital Southampton NHS FT</name>
      <address>
        <city>Southampton</city>
        <zip>SO16 6YD</zip>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Sandy Jack, PhD</last_name>
      <phone>02381205308</phone>
      <email>s.jack@soton.ac.uk</email>
    </contact>
  </location>
  <location_countries>
    <country>United Kingdom</country>
  </location_countries>
  <verification_date>June 2022</verification_date>
  <study_first_submitted>June 3, 2020</study_first_submitted>
  <study_first_submitted_qc>June 5, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 11, 2020</study_first_posted>
  <last_update_submitted>June 7, 2022</last_update_submitted>
  <last_update_submitted_qc>June 7, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">June 8, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>COVID-19</keyword>
  <keyword>Virtual clinics</keyword>
  <keyword>Exercise</keyword>
  <keyword>Cancer diagnosis</keyword>
  <keyword>Nutrition</keyword>
  <keyword>Psychological support</keyword>
  <keyword>Behaviour change</keyword>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04425616
org study id: RHM CRI 0403
nct id: NCT04425616
lead sponsor: 
collaborator: 
collaborator: 
collaborator: 
is fda regulated drug: No
is fda regulated device: No
Trial Phase: Phase III: Interventional Trial: Virtual clinics to deliver universal
      interventions to maintain and improve physical health, nutritional state and psychological
      wellbeing in people with cancer who are following social distancing guidance: A COVID-19
      targeted trial.

      Indication: Male or female participants, aged over 18 years old with suspicion or confirmed
      diagnosis of cancer (does not require histological confirmation)

      Objective: To investigate the efficacy of remote multimodal universal interventions delivered
      via virtual clinics to improve physical function as measured by the EORTC-QLQ-C30.

      Secondary Objective:

      To investigate the efficacy of remote multimodal universal interventions delivered via
      virtual clinics to improve emotional function, quality of life, participant activation (PAM),
      behaviour change and the effect it has on health economics (EQ-5D-5L).

      Exploratory Objective:

      Overall Survival and adherence to the intervention/advice using validated tools or
      development of a web-based toolkit.
Rationale: A recent statement by Professor Chris Whitty, Chief Medical Officer, NHS England,
      emphasised the significant benefits of exercise for all people. He said, "this may be
      challenging for people self-isolating and even more so for those highly vulnerable people
      that are having to shield against the virus in their own homes" The coronavirus (COVID-19)
      pandemic has led to many changes to everyday life including the introduction of social
      distancing as well as restriction of travel. Treatment plans for patients with cancer are
      being revised or modified due to risks and benefits of certain treatments in light of the
      COVID-19 risk. The number of deaths due to the disruption in cancer services is likely to
      outweigh the number of deaths from coronavirus itself over the next five years.

      The effects of this pandemic has reportedly led to increased anxiety and distress and risks
      deconditioning due to reduced physical activity. The interventions we are proposing aim to
      enable people with cancer to optimise their physical health, nutritional state and
      psychological wellbeing and prepare for their treatment pathway (current or modified) and
      recovery during this uncertain time through exercise, nutrition and psychological support.

      The aim is to investigate whether the promotion of these interventions delivered via virtual
      clinics, in socially distanced people with cancer, can improve physical and psychological
      function and self-efficacy to self-manage. We are also aiming to evaluate health economics
      whilst following the COVID-19 government guidelines.

      Trial Design: Phase III: Non randomised Interventional Trial

      Sample Size: 1100

      Intervention: Provision of dietary, exercise and psychological advice as well as behaviour
      change support (universal interventions) as aligned to the universal interventions (with the
      caveats of COVID-19) in the Macmillan 'Principles and guidance for prehabilitation within the
      management and support of people with cancer' guideline. This complex intervention will be
      prescribed and delivered through virtual clinics where CanRehab professionals will support
      the individual. Level 3 Personal Trainers may also deliver the interventions in some cases
      with a GP referral qualification and who are competent in delivering the interventions to
      participants with cancer post-treatment.
allocation: N/A
intervention model: Single Group Assignment
intervention model description: Non-randomised phase III interventional trial
primary purpose: Treatment
masking: None (Open Label)
measure: Physical Function
time frame: Baseline up to 1 year post enrolment
description: Physical function will be measured using the EORTC-QLQ-C30. Participants will choose from the choices 1 = Not at all; 2 = A little, 3 = Quite a bit, 4 = Very much
measure: Emotional Function
time frame: Baseline up to 1 year post enrolment
description: Emotional function will be measured using the EORTC-QLQ-C30. Participants will choose from the choices 1 = Not at all; 2 = A little, 3 = Quite a bit, 4 = Very much
measure: Health related quality of life
time frame: Baseline up to 1 year post enrolment
description: EQ-5D-5L is a standardised measure of health status developed by the EuroQol Group. Applicable to a wide range of health conditions and treatments, it provides a simple descriptive profile and a single index value for health status that can be used in the clinical evaluation of health care
measure: Health economics analysis
time frame: Baseline up to 1 year post enrolment
description: EQ-5D-5L is a standardised measure of health status developed by the EuroQol Group. Applicable to a wide range of health conditions and treatments, it provides a simple descriptive profile and a single index value for health status that can be used in the economic evaluation of health care
measure: Patient activation
time frame: Baseline up to 1 year post enrolment
description: Patients knowledge skills and confidence to manage their own health and care will be measured using the Patient Activation Measure (PAM)
Agreement or disagreement with statements. Choice between disagree strongly, disagree, agree, agree strongly and not applicable
measure: Self-reported physical activity
time frame: Baseline up to 1 year post enrolment
description: Measured using the Godin Leisure Time Exercise Questionnaire, a 7-day physical activity recall
measure: Nutrition assessment
time frame: Baseline up to 1 year post enrolment
description: In the oncology population where malnutrition prevalence is high, the Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) is a descriptive screening tool that can provide further information to assist triaging and capture acute change in nutritional state
measure: Self-efficacy for self-management of chronic disease
time frame: Baseline up to 1 year post enrolment
description: Self-efficacy (confidence) to self-manage chronic disease (SEMCD), measured using the Lorig SEMCD scale
A confidence scale that represents the patients confidence that a regular task can be achieved. 1 = Not confident at all and 10= totally confident.
measure: Distress levels
time frame: Baseline up to 1 year post enrolment
description: Levels of distress as measured by the Emotions Thermometers. Participants will score on a scale where 0 = None and 10 = Extreme
measure: Functional capacity
time frame: Baseline up to 1 year post enrolment
description: The Dukes Activity Status Index is a 12 item self-report measure of functional capacity that can be used to estimate peak oxygen uptake
measure: The impact of COVID-19 pandemic on psychological functioning
time frame: Baseline up to 1 year post enrolment
description: As measured by the Impact of Event Scale - a 22-item self-report measure of the imapact of a specific traumatic event against the DSM criteria for Post Traumatic Stress Disorder. 0 = Not at all and 4 = Extremely.
measure: Process Evaluation
time frame: Through study completion, an average of 12 months
description: Semi-structured interviews with participants and professionals to explore acceptability, usefulness and barriers to delivery/engagement
measure: Exploratory: Overall survival
time frame: 1 year post enrolment
description: Overall survival at 1 year following date of enrolment
measure: Exploratory: Adherence to the interventions/advice
time frame: Baseline up to 1 year post enrolment
description: Adherence to intervention advice is defined as number of sessions the participants attends divided by the total number of sessions.
arm group label: Universal Interventions
arm group type: Experimental
description: The delivery of nutrition, exercise and psychological interventions delivered in the following structure:
Month 1: Up to three times per week
Months 2-3: Once per week
Months 4 - 6: One session per month for the last 3 months
intervention type: Other
intervention name: Exercise
description: At least one and up to three supervised sessions per week including:
aerobic exercise at a rating of perceived exertion of 11-14 (6-20 scale) accumulating 20 minutes per session
resistance exercise of 8-10 exercises for 2x 8-15 repetitions performed in a controlled manner and covering the whole body
Range of motion exercise performed through pain free range of motion covering the whole body to be maintained in good alignment for 10-30 seconds, with some movements held for a second set of 10-30 seconds if stiff
arm group label: Universal Interventions
intervention type: Behavioral
intervention name: Psychological and Behaviour Change Support
description: Instructors will be trained in Healthy Conversation Skills (HCS), Making Every Contact Count (MECC) or equivalent. This will enable them to deliver brief participant centred empowering interventions informed by social cognitive theory. This skill set will be used to support participants in adopting and maintaining the prescribed exercise and diet programme as well as adopting and practicing strategies to self-manage psychological well-being. Participants will be given the option to be provided with a SMARTER goal setting sheet to assist with goal planning. Applicable standardised psychological support resources will be made available to the participants though the Macmillan resource repository that they can access online or in alternative format as necessary, for example relaxation and mindfulness exercises
arm group label: Universal Interventions
intervention type: Other
intervention name: Nutrition
description: Instructors will receive training in generic nutritional principles in line with recommendations from World Cancer Research Fund (WCRF) and British Dietetic Association, and will work with participant to review own diet and eating habits against WCRF recommendations to enable goal setting and identify links to existing resources reputable websites, outputs and on-line forums. These would include: principles of healthy eating ('eat well' advice), weight management, symptom management, prehab advice before treatment starts, rehab advice during and after treatment. The participant will be asked if they are eating and drinking well or have any concerns at the beginning of each exercise session. Further support will be provided to instructors to address participant concerns or requests for additional information.
arm group label: Universal Interventions
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Sandy Jack, pHD
phone: 02381205308
email: s.jack@soton.ac.uk
last name: Samantha Leggett, BSc
phone: 02381208519
email: samantha.leggett@uhs.nhs.uk
facility: 
status: Recruiting
contact: 
country: United Kingdom
responsible party type: Sponsor
sharing ipd: No