<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04460391</url>
  </required_header>
  <id_info>
    <org_study_id>Intensive rehabilitation</org_study_id>
    <nct_id>NCT04460391</nct_id>
  </id_info>
  <brief_title>Influence of Early Standing Training on ICU Patients</brief_title>
  <official_title>Influence of Early Standing Training on ICU Patients</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Chinese PLA General Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Chinese PLA General Hospital</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Influence of early standing training on ICU patients&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Objective: To study the effect of early standing training on ICU patients.Background: Early&#xD;
      severe rehabilitation is of great significance for patients, which can help patients withdraw&#xD;
      from mechanical ventilation as soon as possible, improve pulmonary ventilation, and promote&#xD;
      early walking.However, patients on mechanical ventilation are more prone to delirium, muscle&#xD;
      weakness, ventilator dependence and other problems. Early standing training can significantly&#xD;
      improve patients' lower limb muscle strength, improve diaphragm function, improve the&#xD;
      prognosis of patients, and reduce the length of hospital stay.Methods: selecting stable&#xD;
      hemodynamics in ICU patients with mechanical ventilation, randomly divided into two groups, a&#xD;
      group of routine rehabilitation training, another group stand for regular rehabilitation and&#xD;
      early training, with the aid of electric beds, on the first day of patients, to evaluate the&#xD;
      seventh day, the 14th day, and collect the basic information for patients and strength&#xD;
      assessment, blood gas analysis, the diaphragm of the bed and ultrasound and muscle&#xD;
      ultrasound, and record the patient's mortality within 28 days, the incidence of delirium,&#xD;
      decannulation rate, etc., recorded in patients with mechanical ventilation time and the time&#xD;
      required to walk independently and ICU stay time.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Not yet recruiting</last_known_status>
  <start_date type="Anticipated">October 1, 2020</start_date>
  <completion_date type="Anticipated">October 1, 2021</completion_date>
  <primary_completion_date type="Anticipated">October 1, 2021</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Care Provider)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Medical Research Council</measure>
    <time_frame>day 1</time_frame>
    <description>Muscle strength assessment of ICU patients，Out of 60 points，Less than 48 points had acquired muscle weakness in the ICU.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Medical Research Council</measure>
    <time_frame>day 7</time_frame>
    <description>Muscle strength assessment of ICU patients，Out of 60 points，Less than 48 points had acquired muscle weakness in the ICU.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Medical Research Council</measure>
    <time_frame>day 14</time_frame>
    <description>Muscle strength assessment of ICU patients，Out of 60 points，Less than 48 points had acquired muscle weakness in the ICU.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Berg Balance Scale</measure>
    <time_frame>day 1</time_frame>
    <description>Balance grade score,The highest 56 points,The higher the score, the better the balance.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Berg Balance Scale</measure>
    <time_frame>day 7</time_frame>
    <description>Balance grade score,The highest 56 points,The higher the score, the better the balance.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Berg Balance Scale</measure>
    <time_frame>day 14</time_frame>
    <description>Balance grade score,The highest 56 points,The higher the score, the better the balance.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>FIM Function Independent Scale</measure>
    <time_frame>day 1</time_frame>
    <description>Functional independence assessment,The lowest score is 18 and the highest is 126,The higher the score, the more independent it is.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>FIM Function Independent Scale</measure>
    <time_frame>day 7</time_frame>
    <description>Functional independence assessment,The lowest score is 18 and the highest is 126,The higher the score, the more independent it is.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>FIM Function Independent Scale</measure>
    <time_frame>day 14</time_frame>
    <description>Functional independence assessment,The lowest score is 18 and the highest is 126,The higher the score, the more independent it is.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Holden walk classification</measure>
    <time_frame>day 1</time_frame>
    <description>Levels 0 to 5,The higher the grade, the better the ability to walk</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Holden walk classification</measure>
    <time_frame>day 7</time_frame>
    <description>Levels 0 to 5,The higher the grade, the better the ability to walk</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Holden walk classification</measure>
    <time_frame>day 14</time_frame>
    <description>Levels 0 to 5,The higher the grade, the better the ability to walk</description>
  </primary_outcome>
  <primary_outcome>
    <measure>arterial blood gas analysis</measure>
    <time_frame>day 1</time_frame>
    <description>PH,normal range 7.35-7.45</description>
  </primary_outcome>
  <primary_outcome>
    <measure>arterial blood gas analysis</measure>
    <time_frame>day 7</time_frame>
    <description>PH,normal range 7.35-7.45</description>
  </primary_outcome>
  <primary_outcome>
    <measure>arterial blood gas analysis</measure>
    <time_frame>day 14</time_frame>
    <description>PH,normal range 7.35-7.45</description>
  </primary_outcome>
  <primary_outcome>
    <measure>partial pressure of carbon dioxide</measure>
    <time_frame>day 1</time_frame>
    <description>normal range 35-45 mmHg</description>
  </primary_outcome>
  <primary_outcome>
    <measure>partial pressure of carbon dioxide</measure>
    <time_frame>day 7</time_frame>
    <description>normal range 35-45 mmHg</description>
  </primary_outcome>
  <primary_outcome>
    <measure>partial pressure of carbon dioxide</measure>
    <time_frame>day 14</time_frame>
    <description>normal range 35-45 mmHg</description>
  </primary_outcome>
  <primary_outcome>
    <measure>oxygenation index</measure>
    <time_frame>day 1</time_frame>
    <description>Normal adults are 400,the higher，the better</description>
  </primary_outcome>
  <primary_outcome>
    <measure>oxygenation index</measure>
    <time_frame>day 7</time_frame>
    <description>Normal adults are 400,the higher，the better</description>
  </primary_outcome>
  <primary_outcome>
    <measure>oxygenation index</measure>
    <time_frame>day 14</time_frame>
    <description>Normal adults are 400,the higher，the better</description>
  </primary_outcome>
  <primary_outcome>
    <measure>lactic acid</measure>
    <time_frame>day 1</time_frame>
    <description>normal range 0.5-1.6mmol/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>lactic acid</measure>
    <time_frame>day 7</time_frame>
    <description>normal range 0.5-1.6mmol/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>lactic acid</measure>
    <time_frame>day 14</time_frame>
    <description>normal range 0.5-1.6mmol/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragmatic movement</measure>
    <time_frame>day 1</time_frame>
    <description>The distance the diaphragm moves downward during inhalation,Normal adults are 1.4cm.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragmatic movement</measure>
    <time_frame>day 7</time_frame>
    <description>The distance the diaphragm moves downward during inhalation,Normal adults are 1.4cm.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragmatic movement</measure>
    <time_frame>day 14</time_frame>
    <description>The distance the diaphragm moves downward during inhalation,Normal adults are 1.4cm.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragm contraction rate</measure>
    <time_frame>day 1</time_frame>
    <description>Normal adults are 1.3cm/s</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragm contraction rate</measure>
    <time_frame>day 7</time_frame>
    <description>Normal adults are 1.3cm/s</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragm contraction rate</measure>
    <time_frame>day 14</time_frame>
    <description>Normal adults are 1.3cm/s</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragm thickness at end of breath</measure>
    <time_frame>day 1</time_frame>
    <description>Normal adults are 0.15cm</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragm thickness at end of breath</measure>
    <time_frame>day 7</time_frame>
    <description>Normal adults are 0.15cm</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragm thickness at end of breath</measure>
    <time_frame>day 14</time_frame>
    <description>Normal adults are 0.15cm</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragm thickness at end of inhalation</measure>
    <time_frame>day 1</time_frame>
    <description>Normal adults are 0.28cm</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragm thickness at end of inhalation</measure>
    <time_frame>day 7</time_frame>
    <description>Normal adults are 0.28cm</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragm thickness at end of inhalation</measure>
    <time_frame>day 14</time_frame>
    <description>Normal adults are 0.28cm</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragmatic thickness variation rate</measure>
    <time_frame>day 1</time_frame>
    <description>Less than 20% have diaphragmatic dysfunction</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragmatic thickness variation rate</measure>
    <time_frame>day 7</time_frame>
    <description>Less than 20% have diaphragmatic dysfunction</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diaphragmatic thickness variation rate</measure>
    <time_frame>day 14</time_frame>
    <description>Less than 20% have diaphragmatic dysfunction</description>
  </primary_outcome>
  <primary_outcome>
    <measure>E-T index</measure>
    <time_frame>day 1</time_frame>
    <description>Product of inspiratory time and diaphragmatic mobility,The higher the extubation success rate, the higher the extubation success rate.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>E-T index</measure>
    <time_frame>day 7</time_frame>
    <description>Product of inspiratory time and diaphragmatic mobility,The higher the extubation success rate, the higher the extubation success rate.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>E-T index</measure>
    <time_frame>day 14</time_frame>
    <description>Product of inspiratory time and diaphragmatic mobility,The higher the extubation success rate, the higher the extubation success rate.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Timed Inspiration</measure>
    <time_frame>day 1</time_frame>
    <description>Normal adults are 1s</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Timed Inspiration</measure>
    <time_frame>day 7</time_frame>
    <description>Normal adults are 1s</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Timed Inspiration</measure>
    <time_frame>day 14</time_frame>
    <description>Normal adults are 1s</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Rectus femoris thickness</measure>
    <time_frame>day 1</time_frame>
    <description>The thicker the muscle, the better</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Rectus femoris thickness</measure>
    <time_frame>day 7</time_frame>
    <description>The thicker the muscle, the better</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Rectus femoris thickness</measure>
    <time_frame>day 14</time_frame>
    <description>The thicker the muscle, the better</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thickness of tibialis anterior muscle</measure>
    <time_frame>day 1</time_frame>
    <description>The thicker the muscle, the better</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thickness of tibialis anterior muscle</measure>
    <time_frame>day 7</time_frame>
    <description>The thicker the muscle, the better</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thickness of tibialis anterior muscle</measure>
    <time_frame>day 14</time_frame>
    <description>The thicker the muscle, the better</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Mechanical ventilation time</measure>
    <time_frame>three months</time_frame>
    <description>Mechanical ventilation time</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>icu length of stay</measure>
    <time_frame>three months</time_frame>
    <description>icu length of stay</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Time required for independent walking</measure>
    <time_frame>three months</time_frame>
    <description>Time required for independent walking</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>delirium</measure>
    <time_frame>28 days</time_frame>
    <description>Confusion Assessment Method of the Intensive Care Unit. Positive is delirium.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>mortality</measure>
    <time_frame>28 days</time_frame>
    <description>mortality</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>reintubation</measure>
    <time_frame>28 days</time_frame>
    <description>Note whether intubation was performed within 28 days.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">50</enrollment>
  <condition>Pulmonary Disease</condition>
  <arm_group>
    <arm_group_label>experimental group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Early standing training and routine rehabilitation</description>
  </arm_group>
  <arm_group>
    <arm_group_label>control group</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Conventional rehabilitation，Muscle training and breathing training</description>
  </arm_group>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Intensive rehabilitation</intervention_name>
    <description>Early standing training and routine rehabilitation</description>
    <arm_group_label>control group</arm_group_label>
    <arm_group_label>experimental group</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  The age is ≥ 18 years old;&#xD;
&#xD;
          -  the hemodynamics is stable;&#xD;
&#xD;
          -  50 &lt; heart rate &lt; 120 beats / min ;&#xD;
&#xD;
          -  90 &lt; systolic blood pressure &lt; 200mmHg ;&#xD;
&#xD;
          -  55 &lt; mean arterial pressure &lt; 120mmHg;&#xD;
&#xD;
          -  do not increase the dose of pressor drugs for at least 2 hours;&#xD;
&#xD;
          -  intracranial pressure is stable and there are no seizures within 24 hours;&#xD;
&#xD;
          -  the respiratory state is stable;&#xD;
&#xD;
          -  the patient's finger pulse oxygen saturation ≥ 88%;&#xD;
&#xD;
          -  Oxygen concentration less than 60%；&#xD;
&#xD;
          -  Terminal positive expiratory pressure&lt;12cmH2O；&#xD;
&#xD;
          -  10 &lt; respiratory frequency &lt; 35 beats / min.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Pregnancy;&#xD;
&#xD;
          -  acute cardio-cerebrovascular events;&#xD;
&#xD;
          -  spinal or limb fractures;&#xD;
&#xD;
          -  active bleeding.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>100 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>xin li xie</last_name>
    <role>Principal Investigator</role>
    <affiliation>The First Medical Center of PLA General Hospital</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Zhao Ying</last_name>
    <phone>17600953801</phone>
    <phone_ext>17600953801</phone_ext>
    <email>1412888703@qq.com</email>
  </overall_contact>
  <verification_date>June 2020</verification_date>
  <study_first_submitted>June 26, 2020</study_first_submitted>
  <study_first_submitted_qc>July 1, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 7, 2020</study_first_posted>
  <last_update_submitted>July 1, 2020</last_update_submitted>
  <last_update_submitted_qc>July 1, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">July 7, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Chinese PLA General Hospital</investigator_affiliation>
    <investigator_full_name>wang kaifei</investigator_full_name>
    <investigator_title>Ph.D.</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Lung Diseases</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04460391
org study id: Intensive rehabilitation
nct id: NCT04460391
lead sponsor: 
is fda regulated drug: No
is fda regulated device: No
Influence of early standing training on ICU patients
Objective: To study the effect of early standing training on ICU patients.Background: Early
      severe rehabilitation is of great significance for patients, which can help patients withdraw
      from mechanical ventilation as soon as possible, improve pulmonary ventilation, and promote
      early walking.However, patients on mechanical ventilation are more prone to delirium, muscle
      weakness, ventilator dependence and other problems. Early standing training can significantly
      improve patients' lower limb muscle strength, improve diaphragm function, improve the
      prognosis of patients, and reduce the length of hospital stay.Methods: selecting stable
      hemodynamics in ICU patients with mechanical ventilation, randomly divided into two groups, a
      group of routine rehabilitation training, another group stand for regular rehabilitation and
      early training, with the aid of electric beds, on the first day of patients, to evaluate the
      seventh day, the 14th day, and collect the basic information for patients and strength
      assessment, blood gas analysis, the diaphragm of the bed and ultrasound and muscle
      ultrasound, and record the patient's mortality within 28 days, the incidence of delirium,
      decannulation rate, etc., recorded in patients with mechanical ventilation time and the time
      required to walk independently and ICU stay time.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Double (Participant, Care Provider)
measure: Medical Research Council
time frame: day 1
description: Muscle strength assessment of ICU patients，Out of 60 points，Less than 48 points had acquired muscle weakness in the ICU.
measure: Medical Research Council
time frame: day 7
description: Muscle strength assessment of ICU patients，Out of 60 points，Less than 48 points had acquired muscle weakness in the ICU.
measure: Medical Research Council
time frame: day 14
description: Muscle strength assessment of ICU patients，Out of 60 points，Less than 48 points had acquired muscle weakness in the ICU.
measure: Berg Balance Scale
time frame: day 1
description: Balance grade score,The highest 56 points,The higher the score, the better the balance.
measure: Berg Balance Scale
time frame: day 7
description: Balance grade score,The highest 56 points,The higher the score, the better the balance.
measure: Berg Balance Scale
time frame: day 14
description: Balance grade score,The highest 56 points,The higher the score, the better the balance.
measure: FIM Function Independent Scale
time frame: day 1
description: Functional independence assessment,The lowest score is 18 and the highest is 126,The higher the score, the more independent it is.
measure: FIM Function Independent Scale
time frame: day 7
description: Functional independence assessment,The lowest score is 18 and the highest is 126,The higher the score, the more independent it is.
measure: FIM Function Independent Scale
time frame: day 14
description: Functional independence assessment,The lowest score is 18 and the highest is 126,The higher the score, the more independent it is.
measure: Holden walk classification
time frame: day 1
description: Levels 0 to 5,The higher the grade, the better the ability to walk
measure: Holden walk classification
time frame: day 7
description: Levels 0 to 5,The higher the grade, the better the ability to walk
measure: Holden walk classification
time frame: day 14
description: Levels 0 to 5,The higher the grade, the better the ability to walk
measure: arterial blood gas analysis
time frame: day 1
description: PH,normal range 7.35-7.45
measure: arterial blood gas analysis
time frame: day 7
description: PH,normal range 7.35-7.45
measure: arterial blood gas analysis
time frame: day 14
description: PH,normal range 7.35-7.45
measure: partial pressure of carbon dioxide
time frame: day 1
description: normal range 35-45 mmHg
measure: partial pressure of carbon dioxide
time frame: day 7
description: normal range 35-45 mmHg
measure: partial pressure of carbon dioxide
time frame: day 14
description: normal range 35-45 mmHg
measure: oxygenation index
time frame: day 1
description: Normal adults are 400,the higher，the better
measure: oxygenation index
time frame: day 7
description: Normal adults are 400,the higher，the better
measure: oxygenation index
time frame: day 14
description: Normal adults are 400,the higher，the better
measure: lactic acid
time frame: day 1
description: normal range 0.5-1.6mmol/L
measure: lactic acid
time frame: day 7
description: normal range 0.5-1.6mmol/L
measure: lactic acid
time frame: day 14
description: normal range 0.5-1.6mmol/L
measure: Diaphragmatic movement
time frame: day 1
description: The distance the diaphragm moves downward during inhalation,Normal adults are 1.4cm.
measure: Diaphragmatic movement
time frame: day 7
description: The distance the diaphragm moves downward during inhalation,Normal adults are 1.4cm.
measure: Diaphragmatic movement
time frame: day 14
description: The distance the diaphragm moves downward during inhalation,Normal adults are 1.4cm.
measure: Diaphragm contraction rate
time frame: day 1
description: Normal adults are 1.3cm/s
measure: Diaphragm contraction rate
time frame: day 7
description: Normal adults are 1.3cm/s
measure: Diaphragm contraction rate
time frame: day 14
description: Normal adults are 1.3cm/s
measure: Diaphragm thickness at end of breath
time frame: day 1
description: Normal adults are 0.15cm
measure: Diaphragm thickness at end of breath
time frame: day 7
description: Normal adults are 0.15cm
measure: Diaphragm thickness at end of breath
time frame: day 14
description: Normal adults are 0.15cm
measure: Diaphragm thickness at end of inhalation
time frame: day 1
description: Normal adults are 0.28cm
measure: Diaphragm thickness at end of inhalation
time frame: day 7
description: Normal adults are 0.28cm
measure: Diaphragm thickness at end of inhalation
time frame: day 14
description: Normal adults are 0.28cm
measure: Diaphragmatic thickness variation rate
time frame: day 1
description: Less than 20% have diaphragmatic dysfunction
measure: Diaphragmatic thickness variation rate
time frame: day 7
description: Less than 20% have diaphragmatic dysfunction
measure: Diaphragmatic thickness variation rate
time frame: day 14
description: Less than 20% have diaphragmatic dysfunction
measure: E-T index
time frame: day 1
description: Product of inspiratory time and diaphragmatic mobility,The higher the extubation success rate, the higher the extubation success rate.
measure: E-T index
time frame: day 7
description: Product of inspiratory time and diaphragmatic mobility,The higher the extubation success rate, the higher the extubation success rate.
measure: E-T index
time frame: day 14
description: Product of inspiratory time and diaphragmatic mobility,The higher the extubation success rate, the higher the extubation success rate.
measure: Timed Inspiration
time frame: day 1
description: Normal adults are 1s
measure: Timed Inspiration
time frame: day 7
description: Normal adults are 1s
measure: Timed Inspiration
time frame: day 14
description: Normal adults are 1s
measure: Rectus femoris thickness
time frame: day 1
description: The thicker the muscle, the better
measure: Rectus femoris thickness
time frame: day 7
description: The thicker the muscle, the better
measure: Rectus femoris thickness
time frame: day 14
description: The thicker the muscle, the better
measure: Thickness of tibialis anterior muscle
time frame: day 1
description: The thicker the muscle, the better
measure: Thickness of tibialis anterior muscle
time frame: day 7
description: The thicker the muscle, the better
measure: Thickness of tibialis anterior muscle
time frame: day 14
description: The thicker the muscle, the better
measure: Mechanical ventilation time
time frame: three months
description: Mechanical ventilation time
measure: icu length of stay
time frame: three months
description: icu length of stay
measure: Time required for independent walking
time frame: three months
description: Time required for independent walking
measure: delirium
time frame: 28 days
description: Confusion Assessment Method of the Intensive Care Unit. Positive is delirium.
measure: mortality
time frame: 28 days
description: mortality
measure: reintubation
time frame: 28 days
description: Note whether intubation was performed within 28 days.
arm group label: experimental group
arm group type: Experimental
description: Early standing training and routine rehabilitation
arm group label: control group
arm group type: Active Comparator
description: Conventional rehabilitation，Muscle training and breathing training
intervention type: Behavioral
intervention name: Intensive rehabilitation
description: Early standing training and routine rehabilitation
arm group label: control group
arm group label: experimental group
criteria: 
gender: All
minimum age: 18 Years
maximum age: 100 Years
healthy volunteers: No
last name: xin li xie
role: Principal Investigator
affiliation: The First Medical Center of PLA General Hospital
last name: Zhao Ying
phone: 17600953801
phone ext: 17600953801
email: 1412888703@qq.com
responsible party type: Principal Investigator
investigator affiliation: Chinese PLA General Hospital
investigator full name: wang kaifei
investigator title: Ph.D.
mesh term: Lung Diseases