<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04434144</url>
  </required_header>
  <id_info>
    <org_study_id>10000918</org_study_id>
    <nct_id>NCT04434144</nct_id>
  </id_info>
  <brief_title>A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh</brief_title>
  <official_title>A Comparative Observational Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Upazila Health &amp; Family Planning Officer's (UHFPO) Office, Chakoria, Cox's Bazar</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Upazila Health &amp; Family Planning Officer's (UHFPO) Office, Chakoria, Cox's Bazar</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>Yes</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
    <is_us_export>No</is_us_export>
  </oversight_info>
  <brief_summary>
    <textblock>
      COVID19 is a worldwide pandemic. Hence SARS-CoV-2 is a novel virus; there is no specific&#xD;
      medication against it. Like other countries of the world, Bangladesh is also struggling in&#xD;
      the case of treatment of this disease. Besides antiviral drugs other existing drugs like&#xD;
      Hydroxychloroquine, Chloroquine, and recently Ivermectin has been used for the treatment of&#xD;
      mild to moderate cases of COVID19 disease. Till now Hydroxychloroquine has shown a good&#xD;
      effect. Recently anti-parasitic drug Ivermectin was found highly effective in an in-vitro&#xD;
      study against SARS-CoV-2. This study is aimed to evaluate the efficacy of Ivermectin and&#xD;
      Hydroxychloroquine as a combination therapy with antibiotics (Doxycyclin and Azithromycin)&#xD;
      and compare the recovery period of these two drugs applied as core monotherapy.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      This study was done from May 2nd to June 5th, 2020. The investigators included 181 patients&#xD;
      who were tested positive for SARS-CoV-2 infection by RT PCR presented and the sample&#xD;
      collected at Chokoria Upazila Health Complex, Cox's Bazar; Bangladesh. The PCR analysis of&#xD;
      the collected sample was done at Cox's Bazar Medical College. Each of the participants was&#xD;
      examined carefully to find out the details of the disease symptoms, history, comorbid&#xD;
      condition, and associated complaints. Patients with severe comorbid conditions like severe&#xD;
      Bronchial asthma, COPD exacerbation, severe ischemic heart disease, uncontrolled diabetes&#xD;
      mellitus, advanced renal and hepatic disease, carcinoma, hospitalized and Immuno-compromised&#xD;
      patients were not included in this study. 42 patients had comorbid conditions (some required&#xD;
      hospitalization) that might affect the recovery time; 14 patients were unwilling to&#xD;
      participate in the study and 9 participants did not show-up (3 from group A and 6 from group&#xD;
      B) for follow up sample collection so these were excluded. Following exclusion 116 patients&#xD;
      were included with mild to moderate degree of illness with normal or near-normal chest&#xD;
      radiograph and Oxygen Saturation more than 95% were included in this study. All the patients&#xD;
      enrolled in the study were treated as an outpatient protocol.&#xD;
&#xD;
      For the study Perouse the participants were divided into two groups as follows:&#xD;
&#xD;
      Group A (n=60): Ivermectin 200µgm/kg single dose + Doxycycline 100mg BID for 10days.&#xD;
&#xD;
      Group B (n=56): Hydroxychloroquine 400mg first day then 200mg BID for 9days + Azithromycin&#xD;
      500mg daily for 5Days.&#xD;
&#xD;
      Besides the above, symptomatic treatment for fever, headache, cough, myalgia, and other&#xD;
      complaints were given accordingly. Participants were advised for self-isolation, proper&#xD;
      nutrition, hydration, and a sanitary environment. Treatment outcomes were evaluated on every&#xD;
      2days starting from the 5th day (Asymptomatic patients) or the 2nd non-symptomatic day from&#xD;
      the first day of the drug intake by PCR study of nasopharyngeal and throat swab in each&#xD;
      group. Regular contacts were maintained to find out the adverse or side effects of the&#xD;
      therapy. Informed consent was obtained in every case.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">May 2, 2020</start_date>
  <completion_date type="Actual">June 5, 2020</completion_date>
  <primary_completion_date type="Actual">June 5, 2020</primary_completion_date>
  <study_type>Observational [Patient Registry]</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Only</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <target_duration>5 Days</target_duration>
  <primary_outcome>
    <measure>Number of participants with &quot;treatment success&quot; determine by a negative RT PCR for COVID19.</measure>
    <time_frame>02/05/2020 to 05/06/2020</time_frame>
    <description>Treatment outcomes of the COVID19 positive participants will be evaluated on the 5th day in case of an asymptomatic participant; in case of the symptomatic participant, on the 2nd non-symptomatic day onward from the first day of the drug intake by PCR study of nasopharyngeal and throat swab. In the case of still positive PCR, the swab will be collected from the participants after every 2days until the status is negative. A negative PCR is a count of treatment success in each case. The duration (in days) from the first day of drug intake to the negative PCR is the recovery period. Participants who require hospitalization or decease due to the disease progression during the treatment will count as treatment failure.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Number of participants with &quot;adverse effects&quot; determined by the existence of the pharmacological side effects of the particular drug during treatment.</measure>
    <time_frame>02/05/2020 to 05/06/2020</time_frame>
    <description>The adverse effect will define as the symptoms expressed by the participants following the starting of the treatment other than the disease symptoms, those are within the proven/enlisted pharmacological side effects of the particular drug therapy. Adverse effects will be evaluated by communication on phone or during the follow up sample collection by detailed history taking. The degree of symptoms will be noted as continuous/occasional and mild/ moderate/severe.</description>
  </primary_outcome>
  <number_of_groups>2</number_of_groups>
  <enrollment type="Actual">116</enrollment>
  <condition>Ivermectin</condition>
  <condition>Hydroxychloroquine</condition>
  <condition>COVID19</condition>
  <arm_group>
    <arm_group_label>Group A:</arm_group_label>
    <description>Ivermectin 200µgm/kg single dose + Doxycycline 100mg BID for 10days</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Group B</arm_group_label>
    <description>Hydroxychloroquine 400mg first day then 200mg BID for 9days + Azithromycin 500mg daily for 5Days.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Ivermectin + Doxycycline</intervention_name>
    <description>SARS-CoV-2 infection was confirmed by RT PCR in every case. For group A, Ivermectin 200mcg/kg single dose and Doxycycline 100mg BID for 10 days were given. For group B, Hydroxychloroquine 200mg BID for 10 days and Azithromycin 500mg single daily dose for 5days was given. Before advising the contraindications and possible adverse effect and drug interactions were kept in consideration. Incase of asymptomatic patients, repeat sample collection (nasopharyngeal and throat swab) for PCR was done on 5th day. For the symptomatic patients, this duration was on the 3rd nonsymptomatic day from the first day of drug intake. In the case of positive PCR, the test was repeated after 2days and onward.</description>
    <arm_group_label>Group A:</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Hydroxychloroquine + Azithromycin</intervention_name>
    <description>SARS-CoV-2 infection was confirmed by RT PCR in every case. For group B, Hydroxychloroquine 400mg first day then 200mg BID + Azithromycin 500mg BID for 5 days were given. For group B, Hydroxychloroquine 200mg BID for 10 days and Azithromycin 500mg single daily dose for 5days was given. Before advising the contraindications and possible adverse effect and drug interactions were kept in consideration. Incase of asymptomatic patients, repeat sample collection (nasopharyngeal and throat swab) for PCR was done on 5th day. For the symptomatic patients, this duration was on the 2nd nonsymptomatic day from the first day of drug intake. In the case of positive PCR, the test was repeated after 2days and onward.</description>
    <arm_group_label>Group B</arm_group_label>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        The total number of patients was 116; male 84 and female 26, age 16 to 80years, mean age&#xD;
        33.94years.&#xD;
&#xD;
        Group A (Ivermectin + Doxycyclin): male 43 (71.67%), female 17 (28.33%), age 35.72 ± 15.1&#xD;
        years. Male 37and, female 32.88 years.&#xD;
&#xD;
        Group B (Hydroxychloroquine + Azithromycin): male 47 (83.93%), female 9(16.07%), age&#xD;
        31.91years. Male 31.35, and female 34.5 years.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  COVID19 patients confirmed bt RT PCR at Chokoria Upazila Health Complex, Cox's Bazar;&#xD;
             Bangladesh.&#xD;
&#xD;
          -  Patients with mild to moderate degree of illness.&#xD;
&#xD;
          -  Patients with normal or near-normal chest radiograph&#xD;
&#xD;
          -  Patients with oxygen Saturation more than 94% who fit the outpatient treatment&#xD;
             protocol.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Patients with severe uncontrolled comorbid conditions. (Bronchial asthma, COPD&#xD;
             exacerbation, ischemic heart disease, uncontrolled diabetes mellitus, advanced renal&#xD;
             and hepatic disease, carcinoma, hospitalized, Immuno-compromised patients)&#xD;
&#xD;
          -  BMI&gt;30&#xD;
&#xD;
          -  Contraindication / possible drug interaction with Ivermectin and Hydroxychloroquine.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>16 Years</minimum_age>
    <maximum_age>80 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Abu Taiub Mohammed Mohiuddin Chowdhury, MBBS, MD</last_name>
    <role>Study Director</role>
    <affiliation>First Affiliated Hospital Xi'an Jiaotong University</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Mohammad Shahbaz, MBBS, MCPS</last_name>
    <role>Study Chair</role>
    <affiliation>Upazila Health &amp; Family Planning Officer's (UHFPO) Office, Chakoria, Cox's Bazar</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Chakoria Upazilla Health Complex</name>
      <address>
        <city>Cox's Bazar</city>
        <zip>4741</zip>
        <country>Bangladesh</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Bangladesh</country>
  </location_countries>
  <reference>
    <citation>Patri A, Fabbrocini G. Hydroxychloroquine and ivermectin: A synergistic combination for COVID-19 chemoprophylaxis and treatment? J Am Acad Dermatol. 2020 Jun;82(6):e221. doi: 10.1016/j.jaad.2020.04.017. Epub 2020 Apr 10. No abstract available.</citation>
    <PMID>32283237</PMID>
  </reference>
  <reference>
    <citation>Zhou D, Dai SM, Tong Q. COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression. J Antimicrob Chemother. 2020 Jul 1;75(7):1667-1670. doi: 10.1093/jac/dkaa114.</citation>
    <PMID>32196083</PMID>
  </reference>
  <reference>
    <citation>Yao X, Ye F, Zhang M, Cui C, Huang B, Niu P, Liu X, Zhao L, Dong E, Song C, Zhan S, Lu R, Li H, Tan W, Liu D. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Jul 28;71(15):732-739. doi: 10.1093/cid/ciaa237.</citation>
    <PMID>32150618</PMID>
  </reference>
  <reference>
    <citation>Lv C, Liu W, Wang B, Dang R, Qiu L, Ren J, Yan C, Yang Z, Wang X. Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo. Antiviral Res. 2018 Nov;159:55-62. doi: 10.1016/j.antiviral.2018.09.010. Epub 2018 Sep 26.</citation>
    <PMID>30266338</PMID>
  </reference>
  <reference>
    <citation>Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 2020 Jun;178:104787. doi: 10.1016/j.antiviral.2020.104787. Epub 2020 Apr 3.</citation>
    <PMID>32251768</PMID>
  </reference>
  <verification_date>June 2020</verification_date>
  <study_first_submitted>June 9, 2020</study_first_submitted>
  <study_first_submitted_qc>June 14, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 16, 2020</study_first_posted>
  <last_update_submitted>June 14, 2020</last_update_submitted>
  <last_update_submitted_qc>June 14, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">June 16, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>First Affiliated Hospital Xi'an Jiaotong University</investigator_affiliation>
    <investigator_full_name>Abu Taiub Mohammed Mohiuddin Chowdhury</investigator_full_name>
    <investigator_title>Doctoral Resident</investigator_title>
  </responsible_party>
  <keyword>Ivermectin</keyword>
  <keyword>Hydroxychloroquine</keyword>
  <keyword>COVID19</keyword>
  <keyword>Bangladesh</keyword>
  <keyword>SARS-CoV-2</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>COVID-19</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Azithromycin</mesh_term>
    <mesh_term>Doxycycline</mesh_term>
    <mesh_term>Hydroxychloroquine</mesh_term>
    <mesh_term>Ivermectin</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <pending_results>
    <submitted>June 27, 2020</submitted>
    <returned>July 6, 2020</returned>
    <submitted>August 11, 2020</submitted>
    <returned>August 19, 2020</returned>
  </pending_results>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04434144
org study id: 10000918
nct id: NCT04434144
lead sponsor: 
has dmc: Yes
is fda regulated drug: Yes
is fda regulated device: No
is us export: No
COVID19 is a worldwide pandemic. Hence SARS-CoV-2 is a novel virus; there is no specific
      medication against it. Like other countries of the world, Bangladesh is also struggling in
      the case of treatment of this disease. Besides antiviral drugs other existing drugs like
      Hydroxychloroquine, Chloroquine, and recently Ivermectin has been used for the treatment of
      mild to moderate cases of COVID19 disease. Till now Hydroxychloroquine has shown a good
      effect. Recently anti-parasitic drug Ivermectin was found highly effective in an in-vitro
      study against SARS-CoV-2. This study is aimed to evaluate the efficacy of Ivermectin and
      Hydroxychloroquine as a combination therapy with antibiotics (Doxycyclin and Azithromycin)
      and compare the recovery period of these two drugs applied as core monotherapy.
This study was done from May 2nd to June 5th, 2020. The investigators included 181 patients
      who were tested positive for SARS-CoV-2 infection by RT PCR presented and the sample
      collected at Chokoria Upazila Health Complex, Cox's Bazar; Bangladesh. The PCR analysis of
      the collected sample was done at Cox's Bazar Medical College. Each of the participants was
      examined carefully to find out the details of the disease symptoms, history, comorbid
      condition, and associated complaints. Patients with severe comorbid conditions like severe
      Bronchial asthma, COPD exacerbation, severe ischemic heart disease, uncontrolled diabetes
      mellitus, advanced renal and hepatic disease, carcinoma, hospitalized and Immuno-compromised
      patients were not included in this study. 42 patients had comorbid conditions (some required
      hospitalization) that might affect the recovery time; 14 patients were unwilling to
      participate in the study and 9 participants did not show-up (3 from group A and 6 from group
      B) for follow up sample collection so these were excluded. Following exclusion 116 patients
      were included with mild to moderate degree of illness with normal or near-normal chest
      radiograph and Oxygen Saturation more than 95% were included in this study. All the patients
      enrolled in the study were treated as an outpatient protocol.

      For the study Perouse the participants were divided into two groups as follows:

      Group A (n=60): Ivermectin 200µgm/kg single dose + Doxycycline 100mg BID for 10days.

      Group B (n=56): Hydroxychloroquine 400mg first day then 200mg BID for 9days + Azithromycin
      500mg daily for 5Days.

      Besides the above, symptomatic treatment for fever, headache, cough, myalgia, and other
      complaints were given accordingly. Participants were advised for self-isolation, proper
      nutrition, hydration, and a sanitary environment. Treatment outcomes were evaluated on every
      2days starting from the 5th day (Asymptomatic patients) or the 2nd non-symptomatic day from
      the first day of the drug intake by PCR study of nasopharyngeal and throat swab in each
      group. Regular contacts were maintained to find out the adverse or side effects of the
      therapy. Informed consent was obtained in every case.
observational model: Case-Only
time perspective: Prospective
measure: Number of participants with "treatment success" determine by a negative RT PCR for COVID19.
time frame: 02/05/2020 to 05/06/2020
description: Treatment outcomes of the COVID19 positive participants will be evaluated on the 5th day in case of an asymptomatic participant; in case of the symptomatic participant, on the 2nd non-symptomatic day onward from the first day of the drug intake by PCR study of nasopharyngeal and throat swab. In the case of still positive PCR, the swab will be collected from the participants after every 2days until the status is negative. A negative PCR is a count of treatment success in each case. The duration (in days) from the first day of drug intake to the negative PCR is the recovery period. Participants who require hospitalization or decease due to the disease progression during the treatment will count as treatment failure.
measure: Number of participants with "adverse effects" determined by the existence of the pharmacological side effects of the particular drug during treatment.
time frame: 02/05/2020 to 05/06/2020
description: The adverse effect will define as the symptoms expressed by the participants following the starting of the treatment other than the disease symptoms, those are within the proven/enlisted pharmacological side effects of the particular drug therapy. Adverse effects will be evaluated by communication on phone or during the follow up sample collection by detailed history taking. The degree of symptoms will be noted as continuous/occasional and mild/ moderate/severe.
arm group label: Group A:
description: Ivermectin 200µgm/kg single dose + Doxycycline 100mg BID for 10days
arm group label: Group B
description: Hydroxychloroquine 400mg first day then 200mg BID for 9days + Azithromycin 500mg daily for 5Days.
intervention type: Drug
intervention name: Ivermectin + Doxycycline
description: SARS-CoV-2 infection was confirmed by RT PCR in every case. For group A, Ivermectin 200mcg/kg single dose and Doxycycline 100mg BID for 10 days were given. For group B, Hydroxychloroquine 200mg BID for 10 days and Azithromycin 500mg single daily dose for 5days was given. Before advising the contraindications and possible adverse effect and drug interactions were kept in consideration. Incase of asymptomatic patients, repeat sample collection (nasopharyngeal and throat swab) for PCR was done on 5th day. For the symptomatic patients, this duration was on the 3rd nonsymptomatic day from the first day of drug intake. In the case of positive PCR, the test was repeated after 2days and onward.
arm group label: Group A:
intervention type: Drug
intervention name: Hydroxychloroquine + Azithromycin
description: SARS-CoV-2 infection was confirmed by RT PCR in every case. For group B, Hydroxychloroquine 400mg first day then 200mg BID + Azithromycin 500mg BID for 5 days were given. For group B, Hydroxychloroquine 200mg BID for 10 days and Azithromycin 500mg single daily dose for 5days was given. Before advising the contraindications and possible adverse effect and drug interactions were kept in consideration. Incase of asymptomatic patients, repeat sample collection (nasopharyngeal and throat swab) for PCR was done on 5th day. For the symptomatic patients, this duration was on the 2nd nonsymptomatic day from the first day of drug intake. In the case of positive PCR, the test was repeated after 2days and onward.
arm group label: Group B
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 16 Years
maximum age: 80 Years
healthy volunteers: No
last name: Abu Taiub Mohammed Mohiuddin Chowdhury, MBBS, MD
role: Study Director
affiliation: First Affiliated Hospital Xi'an Jiaotong University
last name: Mohammad Shahbaz, MBBS, MCPS
role: Study Chair
affiliation: Upazila Health & Family Planning Officer's (UHFPO) Office, Chakoria, Cox's Bazar
facility: 
country: Bangladesh
citation: Patri A, Fabbrocini G. Hydroxychloroquine and ivermectin: A synergistic combination for COVID-19 chemoprophylaxis and treatment? J Am Acad Dermatol. 2020 Jun;82(6):e221. doi: 10.1016/j.jaad.2020.04.017. Epub 2020 Apr 10. No abstract available.
PMID: 32283237
citation: Zhou D, Dai SM, Tong Q. COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression. J Antimicrob Chemother. 2020 Jul 1;75(7):1667-1670. doi: 10.1093/jac/dkaa114.
PMID: 32196083
citation: Yao X, Ye F, Zhang M, Cui C, Huang B, Niu P, Liu X, Zhao L, Dong E, Song C, Zhan S, Lu R, Li H, Tan W, Liu D. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Jul 28;71(15):732-739. doi: 10.1093/cid/ciaa237.
PMID: 32150618
citation: Lv C, Liu W, Wang B, Dang R, Qiu L, Ren J, Yan C, Yang Z, Wang X. Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo. Antiviral Res. 2018 Nov;159:55-62. doi: 10.1016/j.antiviral.2018.09.010. Epub 2018 Sep 26.
PMID: 30266338
citation: Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 2020 Jun;178:104787. doi: 10.1016/j.antiviral.2020.104787. Epub 2020 Apr 3.
PMID: 32251768
responsible party type: Principal Investigator
investigator affiliation: First Affiliated Hospital Xi'an Jiaotong University
investigator full name: Abu Taiub Mohammed Mohiuddin Chowdhury
investigator title: Doctoral Resident
mesh term: COVID-19
mesh term: Azithromycin
mesh term: Doxycycline
mesh term: Hydroxychloroquine
mesh term: Ivermectin
sharing ipd: Undecided
submitted: June 27, 2020
returned: July 6, 2020
submitted: August 11, 2020
returned: August 19, 2020