<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04491981</url>
  </required_header>
  <id_info>
    <org_study_id>REPAIRC3</org_study_id>
    <nct_id>NCT04491981</nct_id>
  </id_info>
  <brief_title>Restoration Repairs Using Composite Resin Versus Glass Ionomer in Primary Molars: a Randomized Clinical Trial</brief_title>
  <official_title>Longevity of Restoration Repairs Using Composite Resin Versus High Viscosity Glass Ionomer in Primary Molars: Randomized Clinical Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Sao Paulo</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>University of Sao Paulo</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The objective of this randomized clinical study is to evaluate the survival of repairs in&#xD;
      restorations using composite resin (CR) or high viscosity glass ionomer cement (GIC) in&#xD;
      primary molars. This trial is nested to another study (NCT03520309), so patients will be&#xD;
      enrolled from CARDEC 3. 312 restorations will be included and randomized into two groups:&#xD;
      glass ionomer cement (Riva Self Cure, SDI, Australia) and composite resin (Filtek Bulk Fill&#xD;
      and Filtek Bulk Fill Flow, 3M ESPE, USA). After the end of treatments, patients will be&#xD;
      followed for 24 months to assess the success of the restorations, which will be considered as&#xD;
      the absence of the need for reintervention. The Kaplan-Meier survival curves and the log-rank&#xD;
      tests will be performed to assess survival between groups and Cox regression analysis will be&#xD;
      used to compare the outcome with the variables (α = 5%).&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Failed restorations in primary teeth will be repaired using GIC or composite resin.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Not yet recruiting</last_known_status>
  <start_date type="Anticipated">July 1, 2021</start_date>
  <completion_date type="Anticipated">August 1, 2023</completion_date>
  <primary_completion_date type="Anticipated">August 1, 2022</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Clinical success of restorations after repair</measure>
    <time_frame>24 months</time_frame>
    <description>Visual assessment using Frencken criteria for occlusal restoration and Roeleveld et al. criteria for occlusoproximal restorations</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Cost- effectiveness of restorations repairs</measure>
    <time_frame>24 months</time_frame>
    <description>To assess this outcome measure we will consider the percentage of patients needing new operatory interventions and costs will be assessed in monetary units (US dollars)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient's discomfort</measure>
    <time_frame>baseline</time_frame>
    <description>Wong-Baker facial scale - from 0 to 5 (immediately after treatment)</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">312</enrollment>
  <condition>Dental Caries</condition>
  <condition>Dental Caries in Children</condition>
  <arm_group>
    <arm_group_label>Encapsulated Glass Ionomer Cement</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Repair of restorations in primary molars using a high viscosity glass ionomer cement (RIVA Self Cure - SDI)</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Composite resin</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Repair of restorations in primary molars using a composite resin (Filtek Bulk Fill- 3M ESPE)</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Encapsulated Glass Ionomer Cement</intervention_name>
    <description>Repair of restorations in primary molars using Encapsulated High Viscosity Glass Ionomer (RIVA Self Cure - SDI). No local anesthesia will be used. A portion of the former restoration and infected carious tissue can be removed if necessary, and then the restoration will be repaired with GIC (Glass Ionomer Cement).</description>
    <arm_group_label>Encapsulated Glass Ionomer Cement</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Composite resin</intervention_name>
    <description>Repair of restorations in primary molars using composite resin (Filtek Bulk Fill- 3M ESPE.) No local anesthesia will be used.A portion of the former restoration and infected carious tissue can be removed if necessary, and then the restoration will be repaired with CR (composite resin).</description>
    <arm_group_label>Composite resin</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Children who have sought treatment in the School of Dentistry, University of Sao Paulo&#xD;
&#xD;
          -  Children between 3 and 10 years old&#xD;
&#xD;
          -  Children presenting at least one restoration (of any material, any surface and any&#xD;
             integrity status) in primary teeth&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Children whose parents did not agree to participate in the study&#xD;
&#xD;
          -  Children with behavioural issues at the initial exam or who did not assent to&#xD;
             participate in the study&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>3 Years</minimum_age>
    <maximum_age>10 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Daniela P Raggio</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Sao Paulo</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Daniela P Raggio</last_name>
    <phone>+5511976922202</phone>
    <email>danielar@usp.br</email>
  </overall_contact>
  <location>
    <facility>
      <name>University of São Paulo - School of Dentistry</name>
      <address>
        <city>São Paulo</city>
        <zip>05508-000</zip>
        <country>Brazil</country>
      </address>
    </facility>
    <contact>
      <last_name>Daniela P Raggio, Professor</last_name>
      <phone>+ 55 11 976922202</phone>
      <email>danielar@usp.br</email>
    </contact>
  </location>
  <location_countries>
    <country>Brazil</country>
  </location_countries>
  <link>
    <url>https://www.sealedenvelope.com/simple-randomiser/v1/</url>
    <description>Randomization website</description>
  </link>
  <reference>
    <citation>Opdam NJ, van de Sande FH, Bronkhorst E, Cenci MS, Bottenberg P, Pallesen U, Gaengler P, Lindberg A, Huysmans MC, van Dijken JW. Longevity of posterior composite restorations: a systematic review and meta-analysis. J Dent Res. 2014 Oct;93(10):943-9. doi: 10.1177/0022034514544217. Epub 2014 Jul 21.</citation>
    <PMID>25048250</PMID>
  </reference>
  <reference>
    <citation>Moncada G, Vildosola P, Fernandez E, Estay J, de Oliveira Junior OB, de Andrade MF, Martin J, Mjor IA, Gordan VV. Longitudinal results of a 10-year clinical trial of repair of amalgam restorations. Oper Dent. 2015 Jan-Feb;40(1):34-43. doi: 10.2341/14-045-C. Epub 2014 Aug 6.</citation>
    <PMID>25100406</PMID>
  </reference>
  <reference>
    <citation>Gordan VV, Riley JL 3rd, Blaser PK, Mondragon E, Garvan CW, Mjor IA. Alternative treatments to replacement of defective amalgam restorations: results of a seven-year clinical study. J Am Dent Assoc. 2011 Jul;142(7):842-9. doi: 10.14219/jada.archive.2011.0274.</citation>
    <PMID>21719808</PMID>
  </reference>
  <reference>
    <citation>Fernandez E, Martin J, Vildosola P, Oliveira Junior OB, Gordan V, Mjor I, Bersezio C, Estay J, de Andrade MF, Moncada G. Can repair increase the longevity of composite resins? Results of a 10-year clinical trial. J Dent. 2015 Feb;43(2):279-86. doi: 10.1016/j.jdent.2014.05.015. Epub 2014 Jun 4.</citation>
    <PMID>24907560</PMID>
  </reference>
  <reference>
    <citation>Casagrande L, Laske M, Bronkhorst EM, Huysmans MCDNJM, Opdam NJM. Repair may increase survival of direct posterior restorations - A practice based study. J Dent. 2017 Sep;64:30-36. doi: 10.1016/j.jdent.2017.06.002. Epub 2017 Jun 8.</citation>
    <PMID>28602850</PMID>
  </reference>
  <reference>
    <citation>Kanzow P, Wiegand A, Gostemeyer G, Schwendicke F. Understanding the management and teaching of dental restoration repair: Systematic review and meta-analysis of surveys. J Dent. 2018 Feb;69:1-21. doi: 10.1016/j.jdent.2017.09.010. Epub 2017 Sep 21.</citation>
    <PMID>28943362</PMID>
  </reference>
  <reference>
    <citation>Qvist V, Poulsen A, Teglers PT, Mjor IA. The longevity of different restorations in primary teeth. Int J Paediatr Dent. 2010 Jan;20(1):1-7. doi: 10.1111/j.1365-263X.2009.01017.x.</citation>
    <PMID>20059587</PMID>
  </reference>
  <reference>
    <citation>Dias AGA, Magno MB, Delbem ACB, Cunha RF, Maia LC, Pessan JP. Clinical performance of glass ionomer cement and composite resin in Class II restorations in primary teeth: A systematic review and meta-analysis. J Dent. 2018 Jun;73:1-13. doi: 10.1016/j.jdent.2018.04.004. Epub 2018 Apr 9.</citation>
    <PMID>29649506</PMID>
  </reference>
  <reference>
    <citation>Tedesco TK, Calvo AF, Lenzi TL, Hesse D, Guglielmi CA, Camargo LB, Gimenez T, Braga MM, Raggio DP. ART is an alternative for restoring occlusoproximal cavities in primary teeth - evidence from an updated systematic review and meta-analysis. Int J Paediatr Dent. 2017 May;27(3):201-209. doi: 10.1111/ipd.12252. Epub 2016 Aug 4.</citation>
    <PMID>27489205</PMID>
  </reference>
  <reference>
    <citation>Pitts NB, Richards D. Personalized treatment planning. Monogr Oral Sci. 2009;21:128-143. doi: 10.1159/000224217. Epub 2009 Jun 3.</citation>
    <PMID>19494680</PMID>
  </reference>
  <reference>
    <citation>Hickel R, Peschke A, Tyas M, Mjor I, Bayne S, Peters M, Hiller KA, Randall R, Vanherle G, Heintze SD. FDI World Dental Federation: clinical criteria for the evaluation of direct and indirect restorations-update and clinical examples. Clin Oral Investig. 2010 Aug;14(4):349-66. doi: 10.1007/s00784-010-0432-8. Epub 2010 Jul 14.</citation>
    <PMID>20628774</PMID>
  </reference>
  <reference>
    <citation>Ismail AI, Pitts NB, Tellez M; Authors of International Caries Classification and Management System (ICCMS); Banerjee A, Deery C, Douglas G, Eggertsson H, Ekstrand K, Ellwood R, Gomez J, Jablonski-Momeni A, Kolker J, Longbottom C, Manton D, Martignon S, McGrady M, Rechmann P, Ricketts D, Sohn W, Thompson V, Twetman S, Weyant R, Wolff M, Zandona A. The International Caries Classification and Management System (ICCMS) An Example of a Caries Management Pathway. BMC Oral Health. 2015;15 Suppl 1(Suppl 1):S9. doi: 10.1186/1472-6831-15-S1-S9. Epub 2015 Sep 15. No abstract available.</citation>
    <PMID>26391116</PMID>
  </reference>
  <reference>
    <citation>Qvist V, Poulsen A, Teglers PT, Mjor IA. Fluorides leaching from restorative materials and the effect on adjacent teeth. Int Dent J. 2010 Jun;60(3):156-60.</citation>
    <PMID>20684440</PMID>
  </reference>
  <reference>
    <citation>Gordan VV, Riley JL 3rd, Rindal DB, Qvist V, Fellows JL, Dilbone DA, Brotman SG, Gilbert GH; National Dental Practice-Based Research Network Collaborative Group. Repair or replacement of restorations: A prospective cohort study by dentists in The National Dental Practice-Based Research Network. J Am Dent Assoc. 2015 Dec;146(12):895-903. doi: 10.1016/j.adaj.2015.05.017.</citation>
    <PMID>26610834</PMID>
  </reference>
  <reference>
    <citation>Hickel R, Brushaver K, Ilie N. Repair of restorations--criteria for decision making and clinical recommendations. Dent Mater. 2013 Jan;29(1):28-50. doi: 10.1016/j.dental.2012.07.006. Epub 2012 Aug 3.</citation>
    <PMID>22867859</PMID>
  </reference>
  <reference>
    <citation>Frencken JE. Evolution of the the ART approach: highlights and achievements. J Appl Oral Sci. 2009;17 Suppl(spe):78-83. doi: 10.1590/s1678-77572009000700014.</citation>
    <PMID>21499660</PMID>
  </reference>
  <reference>
    <citation>Roeleveld AC, van Amerongen WE, Mandari GJ. Influence of residual caries and cervical gaps on the survival rate of Class II glass ionomer restorations. Eur Arch Paediatr Dent. 2006 Jun;7(2):85-91. doi: 10.1007/BF03320820.</citation>
    <PMID>17140533</PMID>
  </reference>
  <verification_date>April 2021</verification_date>
  <study_first_submitted>June 15, 2020</study_first_submitted>
  <study_first_submitted_qc>July 28, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 30, 2020</study_first_posted>
  <last_update_submitted>April 12, 2021</last_update_submitted>
  <last_update_submitted_qc>April 12, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">April 13, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>University of Sao Paulo</investigator_affiliation>
    <investigator_full_name>Daniela Prócida Raggio</investigator_full_name>
    <investigator_title>Professor Doctor</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Dental Caries</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04491981
org study id: REPAIRC3
nct id: NCT04491981
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
The objective of this randomized clinical study is to evaluate the survival of repairs in
      restorations using composite resin (CR) or high viscosity glass ionomer cement (GIC) in
      primary molars. This trial is nested to another study (NCT03520309), so patients will be
      enrolled from CARDEC 3. 312 restorations will be included and randomized into two groups:
      glass ionomer cement (Riva Self Cure, SDI, Australia) and composite resin (Filtek Bulk Fill
      and Filtek Bulk Fill Flow, 3M ESPE, USA). After the end of treatments, patients will be
      followed for 24 months to assess the success of the restorations, which will be considered as
      the absence of the need for reintervention. The Kaplan-Meier survival curves and the log-rank
      tests will be performed to assess survival between groups and Cox regression analysis will be
      used to compare the outcome with the variables (α = 5%).
Failed restorations in primary teeth will be repaired using GIC or composite resin.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Clinical success of restorations after repair
time frame: 24 months
description: Visual assessment using Frencken criteria for occlusal restoration and Roeleveld et al. criteria for occlusoproximal restorations
measure: Cost- effectiveness of restorations repairs
time frame: 24 months
description: To assess this outcome measure we will consider the percentage of patients needing new operatory interventions and costs will be assessed in monetary units (US dollars)
measure: Patient's discomfort
time frame: baseline
description: Wong-Baker facial scale - from 0 to 5 (immediately after treatment)
arm group label: Encapsulated Glass Ionomer Cement
arm group type: Experimental
description: Repair of restorations in primary molars using a high viscosity glass ionomer cement (RIVA Self Cure - SDI)
arm group label: Composite resin
arm group type: Experimental
description: Repair of restorations in primary molars using a composite resin (Filtek Bulk Fill- 3M ESPE)
intervention type: Procedure
intervention name: Encapsulated Glass Ionomer Cement
description: Repair of restorations in primary molars using Encapsulated High Viscosity Glass Ionomer (RIVA Self Cure - SDI). No local anesthesia will be used. A portion of the former restoration and infected carious tissue can be removed if necessary, and then the restoration will be repaired with GIC (Glass Ionomer Cement).
arm group label: Encapsulated Glass Ionomer Cement
intervention type: Procedure
intervention name: Composite resin
description: Repair of restorations in primary molars using composite resin (Filtek Bulk Fill- 3M ESPE.) No local anesthesia will be used.A portion of the former restoration and infected carious tissue can be removed if necessary, and then the restoration will be repaired with CR (composite resin).
arm group label: Composite resin
criteria: 
gender: All
minimum age: 3 Years
maximum age: 10 Years
healthy volunteers: No
last name: Daniela P Raggio
role: Principal Investigator
affiliation: University of Sao Paulo
last name: Daniela P Raggio
phone: +5511976922202
email: danielar@usp.br
facility: 
contact: 
country: Brazil
url: https://www.sealedenvelope.com/simple-randomiser/v1/
description: Randomization website
citation: Opdam NJ, van de Sande FH, Bronkhorst E, Cenci MS, Bottenberg P, Pallesen U, Gaengler P, Lindberg A, Huysmans MC, van Dijken JW. Longevity of posterior composite restorations: a systematic review and meta-analysis. J Dent Res. 2014 Oct;93(10):943-9. doi: 10.1177/0022034514544217. Epub 2014 Jul 21.
PMID: 25048250
citation: Moncada G, Vildosola P, Fernandez E, Estay J, de Oliveira Junior OB, de Andrade MF, Martin J, Mjor IA, Gordan VV. Longitudinal results of a 10-year clinical trial of repair of amalgam restorations. Oper Dent. 2015 Jan-Feb;40(1):34-43. doi: 10.2341/14-045-C. Epub 2014 Aug 6.
PMID: 25100406
citation: Gordan VV, Riley JL 3rd, Blaser PK, Mondragon E, Garvan CW, Mjor IA. Alternative treatments to replacement of defective amalgam restorations: results of a seven-year clinical study. J Am Dent Assoc. 2011 Jul;142(7):842-9. doi: 10.14219/jada.archive.2011.0274.
PMID: 21719808
citation: Fernandez E, Martin J, Vildosola P, Oliveira Junior OB, Gordan V, Mjor I, Bersezio C, Estay J, de Andrade MF, Moncada G. Can repair increase the longevity of composite resins? Results of a 10-year clinical trial. J Dent. 2015 Feb;43(2):279-86. doi: 10.1016/j.jdent.2014.05.015. Epub 2014 Jun 4.
PMID: 24907560
citation: Casagrande L, Laske M, Bronkhorst EM, Huysmans MCDNJM, Opdam NJM. Repair may increase survival of direct posterior restorations - A practice based study. J Dent. 2017 Sep;64:30-36. doi: 10.1016/j.jdent.2017.06.002. Epub 2017 Jun 8.
PMID: 28602850
citation: Kanzow P, Wiegand A, Gostemeyer G, Schwendicke F. Understanding the management and teaching of dental restoration repair: Systematic review and meta-analysis of surveys. J Dent. 2018 Feb;69:1-21. doi: 10.1016/j.jdent.2017.09.010. Epub 2017 Sep 21.
PMID: 28943362
citation: Qvist V, Poulsen A, Teglers PT, Mjor IA. The longevity of different restorations in primary teeth. Int J Paediatr Dent. 2010 Jan;20(1):1-7. doi: 10.1111/j.1365-263X.2009.01017.x.
PMID: 20059587
citation: Dias AGA, Magno MB, Delbem ACB, Cunha RF, Maia LC, Pessan JP. Clinical performance of glass ionomer cement and composite resin in Class II restorations in primary teeth: A systematic review and meta-analysis. J Dent. 2018 Jun;73:1-13. doi: 10.1016/j.jdent.2018.04.004. Epub 2018 Apr 9.
PMID: 29649506
citation: Tedesco TK, Calvo AF, Lenzi TL, Hesse D, Guglielmi CA, Camargo LB, Gimenez T, Braga MM, Raggio DP. ART is an alternative for restoring occlusoproximal cavities in primary teeth - evidence from an updated systematic review and meta-analysis. Int J Paediatr Dent. 2017 May;27(3):201-209. doi: 10.1111/ipd.12252. Epub 2016 Aug 4.
PMID: 27489205
citation: Pitts NB, Richards D. Personalized treatment planning. Monogr Oral Sci. 2009;21:128-143. doi: 10.1159/000224217. Epub 2009 Jun 3.
PMID: 19494680
citation: Hickel R, Peschke A, Tyas M, Mjor I, Bayne S, Peters M, Hiller KA, Randall R, Vanherle G, Heintze SD. FDI World Dental Federation: clinical criteria for the evaluation of direct and indirect restorations-update and clinical examples. Clin Oral Investig. 2010 Aug;14(4):349-66. doi: 10.1007/s00784-010-0432-8. Epub 2010 Jul 14.
PMID: 20628774
citation: Ismail AI, Pitts NB, Tellez M; Authors of International Caries Classification and Management System (ICCMS); Banerjee A, Deery C, Douglas G, Eggertsson H, Ekstrand K, Ellwood R, Gomez J, Jablonski-Momeni A, Kolker J, Longbottom C, Manton D, Martignon S, McGrady M, Rechmann P, Ricketts D, Sohn W, Thompson V, Twetman S, Weyant R, Wolff M, Zandona A. The International Caries Classification and Management System (ICCMS) An Example of a Caries Management Pathway. BMC Oral Health. 2015;15 Suppl 1(Suppl 1):S9. doi: 10.1186/1472-6831-15-S1-S9. Epub 2015 Sep 15. No abstract available.
PMID: 26391116
citation: Qvist V, Poulsen A, Teglers PT, Mjor IA. Fluorides leaching from restorative materials and the effect on adjacent teeth. Int Dent J. 2010 Jun;60(3):156-60.
PMID: 20684440
citation: Gordan VV, Riley JL 3rd, Rindal DB, Qvist V, Fellows JL, Dilbone DA, Brotman SG, Gilbert GH; National Dental Practice-Based Research Network Collaborative Group. Repair or replacement of restorations: A prospective cohort study by dentists in The National Dental Practice-Based Research Network. J Am Dent Assoc. 2015 Dec;146(12):895-903. doi: 10.1016/j.adaj.2015.05.017.
PMID: 26610834
citation: Hickel R, Brushaver K, Ilie N. Repair of restorations--criteria for decision making and clinical recommendations. Dent Mater. 2013 Jan;29(1):28-50. doi: 10.1016/j.dental.2012.07.006. Epub 2012 Aug 3.
PMID: 22867859
citation: Frencken JE. Evolution of the the ART approach: highlights and achievements. J Appl Oral Sci. 2009;17 Suppl(spe):78-83. doi: 10.1590/s1678-77572009000700014.
PMID: 21499660
citation: Roeleveld AC, van Amerongen WE, Mandari GJ. Influence of residual caries and cervical gaps on the survival rate of Class II glass ionomer restorations. Eur Arch Paediatr Dent. 2006 Jun;7(2):85-91. doi: 10.1007/BF03320820.
PMID: 17140533
responsible party type: Principal Investigator
investigator affiliation: University of Sao Paulo
investigator full name: Daniela Prócida Raggio
investigator title: Professor Doctor
mesh term: Dental Caries