<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04429230</url>
  </required_header>
  <id_info>
    <org_study_id>115632</org_study_id>
    <nct_id>NCT04429230</nct_id>
  </id_info>
  <brief_title>Non-invasive Brain Stimulation in Huntington's Disease</brief_title>
  <official_title>A Trial of Non-invasive Brain Stimulation in Huntington's Disease</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Western University, Canada</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Western University, Canada</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Huntington's disease is a disabling neurodegenerative disease. Patients present with&#xD;
      involuntary movements of the body and cognitive symptoms like behavioral problem, difficulty&#xD;
      in planning tasks, etc. No effective treatment is currently available for them apart from&#xD;
      symptomatic therapy. Currently, studies are going on the effectiveness of noninvasive brain&#xD;
      stimulation (NIBS) in neurodegenerative diseases. It is a mode of brain stimulation technique&#xD;
      where current is delivered into the brain by placing electrodes into their scalp.&#xD;
      Transcranial pulsed current stimulation (tPCS) is a new modality of noninvasive brain&#xD;
      stimulation. It is a device that generates electrical impulses. The current generated from&#xD;
      this device can stimulate underlying brain areas. The investigators have planned to study the&#xD;
      feasibility of non-invasive brain stimulation via tPCS in these patients of Huntington's&#xD;
      disease.&#xD;
&#xD;
      At first, the investigators will rate their involuntary body movement by a standard scale,&#xD;
      assess arm movements by a robotic device, assess speech with standard protocol, assess brain&#xD;
      electrophysiology by electroencephalography (EEG) and will also do gait (walking) analysis.&#xD;
      Next, the investigators will give them 2 week (20 min/day) stimulation via real tPCS (active&#xD;
      stimulation) or placebo (sham stimulation). After 2 weeks of stimulation, the investigators&#xD;
      will re-assess the patient using the same tools mentioned pre-stimulation.&#xD;
&#xD;
      Each patient will receive real and placebo stimulation with a 1-month gap in between. They&#xD;
      will not know whether they are receiving real stimulation or placebo. Assessment will be done&#xD;
      before stimulation, after 2 week real stimulation and after 2 week sham stimulation.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The investigators have planned to study the feasibility of non-invasive brain stimulation via&#xD;
      Transcranial pulsed current stimulation (tPCS) in patients of Huntington's disease. Anodal&#xD;
      stimulation will be given to the brain area based on quantitative electroencephalography&#xD;
      (qEEG) findings.&#xD;
&#xD;
      Patients will be assessed clinically by standard rating scale (UHDRS) and by qEEG, KinArm and&#xD;
      Gait - before and after 2 week (20 min per day) stimulation via tPCS or sham stimulation.&#xD;
&#xD;
      The investigators have planned to assess-&#xD;
&#xD;
        1. Speech&#xD;
&#xD;
        2. Upper limb movement via KinArm. Standard KinArm testing protocol will be used which is&#xD;
           used universally.&#xD;
&#xD;
        3. Gait via Gait Carpet (Zeno Walkway)&#xD;
&#xD;
        4. Quantitative electroencephalography (qEEG)&#xD;
&#xD;
        5. Scale for Huntington's disease (UHDRS) tPCS will be delivered through a pair of&#xD;
           saline-soaked (0.9% NaCl) surface sponge electrodes. Anode will be placed on the scalp&#xD;
           over the area based on qEEG findings. Participant's speech will be recorded using a&#xD;
           head-mounted microphone (AKGc520) and a digital recording device (Zoom H4nPro) while&#xD;
           performing the following calibrated tasks (Calibration involves a sound level meter&#xD;
           placed at 15cm from the mouth while talker says 'ah' at 70dBA) - a. Prolonged 'ah'. b.&#xD;
           Rapid repetitions of the sounds &quot;puh&quot;, &quot;tuh&quot;, and &quot;kuh&quot;. c. Two productions of a&#xD;
           sentence with selected speech sounds (s, sh, p, b, t, i, a, u, ae, ai). &quot;She saw Patty&#xD;
           buy two poppies.&quot; d. Two times louder production of a sentence with selected speech&#xD;
           sounds. &quot;She saw Patty buy two poppies.&quot; e. Repetition of a continuous vowel at normal&#xD;
           and fast rates. 'eye-eye-eyeeye- eye' without making any voice breaks or pauses&quot;. f.&#xD;
           Read aloud a section of a standard passage - standard rainbow passage g. Monologue. Talk&#xD;
           for two minutes about an interesting vacation (or an interesting hobby or activity). The&#xD;
           Zeno walkway will be used in conjunction with the ProtoKinetics Movement Analysis&#xD;
           Software (PKMAS) . The walkway contains a series of pressure sensors to detect&#xD;
           footfalls. These data will be captured and collated via the PKMAS software, resulting in&#xD;
           numerous spatial, temporal and pressure-related gait parameters. Timed-up-and-go (TUG)&#xD;
           task will be used, consisting of rising from chair, walking across the 20-foot gait&#xD;
           carpet, turning around off the carpet, walking back and sitting down. This will be&#xD;
           performed over 3 trials. Gait analysis provides various parameters as output such as&#xD;
           stride length, line of progression, step length, toe-offs and other temporal and spatial&#xD;
           parameters for analysis. Neurophysiological EEG signals will be recorded, eyes-closed,&#xD;
           no-task, using g.Nautilus g.tec wireless system. The g.tech system uses earclip&#xD;
           reference sensors. The subject will be in a quiet place with less light or&#xD;
           electromagnetic perturbations. During the resting state recordings, patients are seated&#xD;
           in a comfortable arm chair and will be instructed to keep relaxed, with their eyes&#xD;
           closed for 5 min. A paired t test will be used to compare baseline data and post tPCS&#xD;
           data. Descriptive analysis of the neurological examination findings will be provided.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Not yet recruiting</last_known_status>
  <start_date type="Anticipated">September 7, 2021</start_date>
  <completion_date type="Anticipated">December 31, 2022</completion_date>
  <primary_completion_date type="Anticipated">September 1, 2022</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Crossover Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Investigator)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Feasibility of recruitment</measure>
    <time_frame>1 year</time_frame>
    <description>Can we recruit 15 HD patients for non-invasive brain stimulation study</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Feasibility of finishing the study</measure>
    <time_frame>1 year</time_frame>
    <description>Can 15 participants finish the study</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Feasibility of home based stimulation</measure>
    <time_frame>1 year</time_frame>
    <description>Can non-invasive brain stimulation in the form of transcranial pulsed current stimulation (tPCS) be appropriately applied at home</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Feasibility of network targeting</measure>
    <time_frame>1 year</time_frame>
    <description>Can dysfunctional brain area in HD be targeted for stimulation non-invasively, using qEEG as a guide</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Change in UHDRS</measure>
    <time_frame>3 months</time_frame>
    <description>The investigators will evaluate the effectiveness of tPCS in patients of Huntington's disease. The investigators will apply Unified Huntington's disease rating scale (UHDRS) pre and post stimulation. The scale is for assessment of chorea, dystonia, ataxia, extraocular movements, speech, gait, postural imbalance. Each subsection can be scored from 0-4. By summing up, the total score ranges from minimum 0 and maximum 124. Higher score means more severity.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in spatiotemporal gait measures using objective gait analysis</measure>
    <time_frame>3 months</time_frame>
    <description>The investigators will use Zeno Walkway Gait carpet and the spatiotemporal details of the gait will be analyzed by ProtoKinetics Movement Analysis Software (PKMAS) software, pre and post stimulation.The Zeno walkway will be used in conjunction with the ProtoKinetics Movement Analysis Software (PKMAS). The walkway contains a series of pressure sensors to detect footfalls. These data will be captured and collated via the PKMAS software, resulting in numerous spatial, temporal and pressure-related gait parameters. Timed-up-and-go (TUG) task will be used, consisting of rising from chair, walking across the 20-foot gait carpet, turning around off the carpet, walking back and sitting down.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in upper limb movements</measure>
    <time_frame>3 months</time_frame>
    <description>The investigators will use KinArm pre and post stimulation to have objective measurement of upper limb movements. KinArm is a robotic manipulator arm. The patients will hold the manipulator arm and move it across to certain points shown on the computer screen. The investigators will use standard KinArm testing protocols to assess upper limb movements.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in speech</measure>
    <time_frame>3 months</time_frame>
    <description>The investigators will use standardized speech protocol pre and post stimulation to assess speech. Participant's speech will be recorded using a head-mounted microphone (AKG-c520) and a digital recording device (Zoom H4nPro) while performing the following calibrated tasks. Calibration involves a sound level meter placed at 15cm from the mouth while talker says 'ah' at 70dBA. The following speech tasks will be assessed- Prolonged phonation, Rapid repetitions of the sounds, Two productions of a sentence with selected speech sounds, Two times louder production of a sentence with selected speech sounds, Repetition of a continuous vowel at normal and fast rates without making any voice breaks or pauses.&#xD;
f) Read aloud a section of a standard passage - standard rainbow passage g) Monologue. Talk for two minutes about an interesting vacation (or an interesting hobby or activity).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in Network fragmentation using Quantitative EEG</measure>
    <time_frame>3 months</time_frame>
    <description>The investigators will do network fragmentation by 5 mins of resting quantitative Electroencephalography (EEG), pre and post stimulation.Quantitative EEG signals will be recorded using g. Nautilus g.tec wireless system. The g. tech system uses ear clip reference sensors. Patient will sit in a comfortable arm chair in a quiet place with less light or electromagnetic perturbations. The patient will be instructed to sit relaxed with eyes closed for 5 min.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">15</enrollment>
  <condition>Huntington Disease</condition>
  <arm_group>
    <arm_group_label>Real tPCS</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Patients of Huntington's disease will be randomly allocated into both the arms. Real tPCS arm will receive active tPCS. Then they will be crossed over to Sham tPCS arm.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Sham tPCS</arm_group_label>
    <arm_group_type>Sham Comparator</arm_group_type>
    <description>Patients of Huntington's disease will be randomly allocated into both the arms. Sham tPCS arm will receive sham tPCS. Then they will be crossed over to Real tPCS arm.</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Active Transcranial pulsed current stimulation (tPCS)</intervention_name>
    <description>Active tPCS will be delivered through a pair of saline soaked (0.9% NaCl) surface sponge electrodes. Anodal stimulation will be given to brain area based on qEEG findings</description>
    <arm_group_label>Real tPCS</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Sham Transcranial pulsed current stimulation (tPCS)</intervention_name>
    <description>Electrode placement will be the same as active stimulation but the electric current will be ramped down 5 seconds after the beginning of the stimulation to make this condition indistinguishable from the experimental active stimulation.</description>
    <arm_group_label>Sham tPCS</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patients of Huntington's disease diagnosed clinically or genetically proved&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  • Patients who can't walk even with support, like wheel chair bound patients.&#xD;
&#xD;
               -  Patients having other issues like stroke that can aggravate speech/ gait.&#xD;
&#xD;
               -  Patients who are not able to provide informed consent.&#xD;
&#xD;
               -  Patients who are unable to communicate by speech and who can't comprehend the&#xD;
                  English language.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>15 Years</minimum_age>
    <maximum_age>75 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Mandar S Jog</last_name>
    <role>Principal Investigator</role>
    <affiliation>London Health Sciences Centre</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Mandar S Jog</last_name>
    <phone>5196676708</phone>
    <phone_ext>3814</phone_ext>
    <email>Mandar.Jog@lhsc.on.ca</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Jacky Ganguly</last_name>
    <email>jganguly@uwo.ca</email>
  </overall_contact_backup>
  <reference>
    <citation>Eddy CM, Shapiro K, Clouter A, Hansen PC, Rickards HE. Transcranial direct current stimulation can enhance working memory in Huntington's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:75-82. doi: 10.1016/j.pnpbp.2017.04.002. Epub 2017 Apr 5.</citation>
    <PMID>28390970</PMID>
  </reference>
  <reference>
    <citation>Berardelli A, Suppa A. Noninvasive brain stimulation in Huntington's disease. Handb Clin Neurol. 2013;116:555-60. doi: 10.1016/B978-0-444-53497-2.00044-9.</citation>
    <PMID>24112923</PMID>
  </reference>
  <verification_date>August 2021</verification_date>
  <study_first_submitted>March 2, 2020</study_first_submitted>
  <study_first_submitted_qc>June 9, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 12, 2020</study_first_posted>
  <last_update_submitted>August 31, 2021</last_update_submitted>
  <last_update_submitted_qc>August 31, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">September 8, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Western University, Canada</investigator_affiliation>
    <investigator_full_name>Mandar Jog</investigator_full_name>
    <investigator_title>Professor</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Huntington Disease</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04429230
org study id: 115632
nct id: NCT04429230
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Huntington's disease is a disabling neurodegenerative disease. Patients present with
      involuntary movements of the body and cognitive symptoms like behavioral problem, difficulty
      in planning tasks, etc. No effective treatment is currently available for them apart from
      symptomatic therapy. Currently, studies are going on the effectiveness of noninvasive brain
      stimulation (NIBS) in neurodegenerative diseases. It is a mode of brain stimulation technique
      where current is delivered into the brain by placing electrodes into their scalp.
      Transcranial pulsed current stimulation (tPCS) is a new modality of noninvasive brain
      stimulation. It is a device that generates electrical impulses. The current generated from
      this device can stimulate underlying brain areas. The investigators have planned to study the
      feasibility of non-invasive brain stimulation via tPCS in these patients of Huntington's
      disease.

      At first, the investigators will rate their involuntary body movement by a standard scale,
      assess arm movements by a robotic device, assess speech with standard protocol, assess brain
      electrophysiology by electroencephalography (EEG) and will also do gait (walking) analysis.
      Next, the investigators will give them 2 week (20 min/day) stimulation via real tPCS (active
      stimulation) or placebo (sham stimulation). After 2 weeks of stimulation, the investigators
      will re-assess the patient using the same tools mentioned pre-stimulation.

      Each patient will receive real and placebo stimulation with a 1-month gap in between. They
      will not know whether they are receiving real stimulation or placebo. Assessment will be done
      before stimulation, after 2 week real stimulation and after 2 week sham stimulation.
The investigators have planned to study the feasibility of non-invasive brain stimulation via
      Transcranial pulsed current stimulation (tPCS) in patients of Huntington's disease. Anodal
      stimulation will be given to the brain area based on quantitative electroencephalography
      (qEEG) findings.

      Patients will be assessed clinically by standard rating scale (UHDRS) and by qEEG, KinArm and
      Gait - before and after 2 week (20 min per day) stimulation via tPCS or sham stimulation.

      The investigators have planned to assess-

        1. Speech

        2. Upper limb movement via KinArm. Standard KinArm testing protocol will be used which is
           used universally.

        3. Gait via Gait Carpet (Zeno Walkway)

        4. Quantitative electroencephalography (qEEG)

        5. Scale for Huntington's disease (UHDRS) tPCS will be delivered through a pair of
           saline-soaked (0.9% NaCl) surface sponge electrodes. Anode will be placed on the scalp
           over the area based on qEEG findings. Participant's speech will be recorded using a
           head-mounted microphone (AKGc520) and a digital recording device (Zoom H4nPro) while
           performing the following calibrated tasks (Calibration involves a sound level meter
           placed at 15cm from the mouth while talker says 'ah' at 70dBA) - a. Prolonged 'ah'. b.
           Rapid repetitions of the sounds "puh", "tuh", and "kuh". c. Two productions of a
           sentence with selected speech sounds (s, sh, p, b, t, i, a, u, ae, ai). "She saw Patty
           buy two poppies." d. Two times louder production of a sentence with selected speech
           sounds. "She saw Patty buy two poppies." e. Repetition of a continuous vowel at normal
           and fast rates. 'eye-eye-eyeeye- eye' without making any voice breaks or pauses". f.
           Read aloud a section of a standard passage - standard rainbow passage g. Monologue. Talk
           for two minutes about an interesting vacation (or an interesting hobby or activity). The
           Zeno walkway will be used in conjunction with the ProtoKinetics Movement Analysis
           Software (PKMAS) . The walkway contains a series of pressure sensors to detect
           footfalls. These data will be captured and collated via the PKMAS software, resulting in
           numerous spatial, temporal and pressure-related gait parameters. Timed-up-and-go (TUG)
           task will be used, consisting of rising from chair, walking across the 20-foot gait
           carpet, turning around off the carpet, walking back and sitting down. This will be
           performed over 3 trials. Gait analysis provides various parameters as output such as
           stride length, line of progression, step length, toe-offs and other temporal and spatial
           parameters for analysis. Neurophysiological EEG signals will be recorded, eyes-closed,
           no-task, using g.Nautilus g.tec wireless system. The g.tech system uses earclip
           reference sensors. The subject will be in a quiet place with less light or
           electromagnetic perturbations. During the resting state recordings, patients are seated
           in a comfortable arm chair and will be instructed to keep relaxed, with their eyes
           closed for 5 min. A paired t test will be used to compare baseline data and post tPCS
           data. Descriptive analysis of the neurological examination findings will be provided.
allocation: Randomized
intervention model: Crossover Assignment
primary purpose: Treatment
masking: Double (Participant, Investigator)
measure: Feasibility of recruitment
time frame: 1 year
description: Can we recruit 15 HD patients for non-invasive brain stimulation study
measure: Feasibility of finishing the study
time frame: 1 year
description: Can 15 participants finish the study
measure: Feasibility of home based stimulation
time frame: 1 year
description: Can non-invasive brain stimulation in the form of transcranial pulsed current stimulation (tPCS) be appropriately applied at home
measure: Feasibility of network targeting
time frame: 1 year
description: Can dysfunctional brain area in HD be targeted for stimulation non-invasively, using qEEG as a guide
measure: Change in UHDRS
time frame: 3 months
description: The investigators will evaluate the effectiveness of tPCS in patients of Huntington's disease. The investigators will apply Unified Huntington's disease rating scale (UHDRS) pre and post stimulation. The scale is for assessment of chorea, dystonia, ataxia, extraocular movements, speech, gait, postural imbalance. Each subsection can be scored from 0-4. By summing up, the total score ranges from minimum 0 and maximum 124. Higher score means more severity.
measure: Changes in spatiotemporal gait measures using objective gait analysis
time frame: 3 months
description: The investigators will use Zeno Walkway Gait carpet and the spatiotemporal details of the gait will be analyzed by ProtoKinetics Movement Analysis Software (PKMAS) software, pre and post stimulation.The Zeno walkway will be used in conjunction with the ProtoKinetics Movement Analysis Software (PKMAS). The walkway contains a series of pressure sensors to detect footfalls. These data will be captured and collated via the PKMAS software, resulting in numerous spatial, temporal and pressure-related gait parameters. Timed-up-and-go (TUG) task will be used, consisting of rising from chair, walking across the 20-foot gait carpet, turning around off the carpet, walking back and sitting down.
measure: Change in upper limb movements
time frame: 3 months
description: The investigators will use KinArm pre and post stimulation to have objective measurement of upper limb movements. KinArm is a robotic manipulator arm. The patients will hold the manipulator arm and move it across to certain points shown on the computer screen. The investigators will use standard KinArm testing protocols to assess upper limb movements.
measure: Change in speech
time frame: 3 months
description: The investigators will use standardized speech protocol pre and post stimulation to assess speech. Participant's speech will be recorded using a head-mounted microphone (AKG-c520) and a digital recording device (Zoom H4nPro) while performing the following calibrated tasks. Calibration involves a sound level meter placed at 15cm from the mouth while talker says 'ah' at 70dBA. The following speech tasks will be assessed- Prolonged phonation, Rapid repetitions of the sounds, Two productions of a sentence with selected speech sounds, Two times louder production of a sentence with selected speech sounds, Repetition of a continuous vowel at normal and fast rates without making any voice breaks or pauses.
f) Read aloud a section of a standard passage - standard rainbow passage g) Monologue. Talk for two minutes about an interesting vacation (or an interesting hobby or activity).
measure: Changes in Network fragmentation using Quantitative EEG
time frame: 3 months
description: The investigators will do network fragmentation by 5 mins of resting quantitative Electroencephalography (EEG), pre and post stimulation.Quantitative EEG signals will be recorded using g. Nautilus g.tec wireless system. The g. tech system uses ear clip reference sensors. Patient will sit in a comfortable arm chair in a quiet place with less light or electromagnetic perturbations. The patient will be instructed to sit relaxed with eyes closed for 5 min.
arm group label: Real tPCS
arm group type: Active Comparator
description: Patients of Huntington's disease will be randomly allocated into both the arms. Real tPCS arm will receive active tPCS. Then they will be crossed over to Sham tPCS arm.
arm group label: Sham tPCS
arm group type: Sham Comparator
description: Patients of Huntington's disease will be randomly allocated into both the arms. Sham tPCS arm will receive sham tPCS. Then they will be crossed over to Real tPCS arm.
intervention type: Device
intervention name: Active Transcranial pulsed current stimulation (tPCS)
description: Active tPCS will be delivered through a pair of saline soaked (0.9% NaCl) surface sponge electrodes. Anodal stimulation will be given to brain area based on qEEG findings
arm group label: Real tPCS
intervention type: Device
intervention name: Sham Transcranial pulsed current stimulation (tPCS)
description: Electrode placement will be the same as active stimulation but the electric current will be ramped down 5 seconds after the beginning of the stimulation to make this condition indistinguishable from the experimental active stimulation.
arm group label: Sham tPCS
criteria: 
gender: All
minimum age: 15 Years
maximum age: 75 Years
healthy volunteers: No
last name: Mandar S Jog
role: Principal Investigator
affiliation: London Health Sciences Centre
last name: Mandar S Jog
phone: 5196676708
phone ext: 3814
email: Mandar.Jog@lhsc.on.ca
last name: Jacky Ganguly
email: jganguly@uwo.ca
citation: Eddy CM, Shapiro K, Clouter A, Hansen PC, Rickards HE. Transcranial direct current stimulation can enhance working memory in Huntington's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jul 3;77:75-82. doi: 10.1016/j.pnpbp.2017.04.002. Epub 2017 Apr 5.
PMID: 28390970
citation: Berardelli A, Suppa A. Noninvasive brain stimulation in Huntington's disease. Handb Clin Neurol. 2013;116:555-60. doi: 10.1016/B978-0-444-53497-2.00044-9.
PMID: 24112923
responsible party type: Principal Investigator
investigator affiliation: Western University, Canada
investigator full name: Mandar Jog
investigator title: Professor
mesh term: Huntington Disease