<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04454749</url>
  </required_header>
  <id_info>
    <org_study_id>2003-ABU-002-BL</org_study_id>
    <nct_id>NCT04454749</nct_id>
  </id_info>
  <brief_title>Endometrial Compaction and Its Influence on Pregnancy Rate in Frozen Embryo Cycle Regimes</brief_title>
  <official_title>Endometrial Compaction and Its Influence on Pregnancy Rate in Frozen Embryo Cycle Regimes</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>ART Fertility Clinics LLC</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>ART Fertility Clinics LLC</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      For a pregnancy to occur, an euploid embryo at blastocyst developmental stage, a receptive&#xD;
      endometrium and the synchrony of both is crucial. Many studies lately investigated the&#xD;
      influence of the endometrial thickness and pattern on the artificial reproductive technology&#xD;
      (ART) outcome, however, with conflicting results.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Further on, the measurement of the endometrial thickness was mostly performed either on the&#xD;
      day of final oocyte maturation in stimulated cycles with fresh embryo transfer or on the day&#xD;
      of progesterone administration in FET cycles.&#xD;
&#xD;
      Progesterone is essential for the secretory transformation and compaction of the endometrium,&#xD;
      prior to implantation. A recently published paper (Haas et al., 2019) however, evaluated the&#xD;
      degree of endometrial compaction under the influence of progesterone in FET cycles and&#xD;
      described, that a lack of certain endometrial compaction has a negative impact on the ongoing&#xD;
      pregnancy rate. As in this study embryos of unknown ploidy status were transferred, the role&#xD;
      of embryo ploidy on the outcome may bias the study results.&#xD;
&#xD;
      In the herein presented study protocol we aim to investigate the influence of endometrial&#xD;
      compaction in FET cycles in which euploid embryos are transferred.&#xD;
&#xD;
      HYPOTHESIS: Lack of endometrial compaction after the start of progesterone leads to an&#xD;
      impaired reproductive outcome.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Terminated</overall_status>
  <why_stopped>
    Investigators perogative&#xD;
  </why_stopped>
  <start_date type="Actual">November 9, 2020</start_date>
  <completion_date type="Actual">March 4, 2021</completion_date>
  <primary_completion_date type="Actual">February 25, 2021</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Ongoing pregnancy rate</measure>
    <time_frame>12 weeks</time_frame>
    <description>Ongoing pregnancy rate (≥ 12 weeks) in patients with endometrial compaction compared to patients without endometrial compaction after frozen embryo transfer of 1 or 2 euploid blastocysts</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Biochemical pregnancy rate in HRT cycle</measure>
    <time_frame>5 weeks</time_frame>
    <description>Positive hCG, but at 5 gestational weeks no ultrasonographic visible gestational sac seen after embryo transfer in HRT-FET cycles with one or two euploid embryos, depending on the degree of compaction.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Biochemical pregnancy rate in spontaneous cycle</measure>
    <time_frame>5 weeks</time_frame>
    <description>positive hCG, but at 5 gestational weeks no ultrasonographic visible gestational sac seen) after embryo transfer in NC-FET cycles with one or two euploid embryos, depending on the degree of compaction.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Clinical implantation rate in HRT cycle</measure>
    <time_frame>6 weeks</time_frame>
    <description>Number of gestational sacs observed by ultrasound at 6 weeks of gestation divided by the number of embryos transferred), defined by a ß-hCG of &gt; 5 IU on day 12 after embryo transfer in HRT-FET cycles with one or two euploid embryos, depending on the degree of compaction</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Clinical implantation rate in spontaneous cycle</measure>
    <time_frame>6 weeks</time_frame>
    <description>Number of gestational sacs observed by ultrasound at 6 weeks of gestation divided by the number of embryos transferred), defined by a ß-hCG of &gt; 5 IU on day 12 after embryo transfer in NC-FET cycles with one or two euploid embryos, depending on the degree of compaction.</description>
  </secondary_outcome>
  <number_of_groups>3</number_of_groups>
  <enrollment type="Actual">3</enrollment>
  <condition>Endometrial Disorder</condition>
  <condition>Infertility, Female</condition>
  <condition>IVF</condition>
  <condition>Pregnancy Early</condition>
  <arm_group>
    <arm_group_label>Stimulated cycles</arm_group_label>
    <description>Ovarian stimulation will be performed by standard protocols. Stimulation medication dosage will be individualised prior to stimulation start according to the ovarian reserve parameters and during ovarian stimulation according to the ovarian response and the measured levels of E2 and progesterone (P4), in order to avoid progesterone elevation during late follicular phase. Final oocyte maturation will be achieved by administration of either 10.000 IU of hCG, 0.3 mg of GnRH agonist (Triptorelin) or dual trigger (hCG and GnRH-analogue), as soon as ≥ 3 follicles ≥ 17 mm are present. Oocyte retrieval will be carried out 36 hours after administration of the trigger. Embryos will undergo PGT-A at blastocyst stage and be vitrified thereafter.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Artificial (HRT) Cycles</arm_group_label>
    <description>Start of estradiol valerate 4mg on day 2 of the cycle for three days. Increase E2 to 6mg on day 4 of E2 treatment. E2 dose may be increased according to clinician discretion based on endometrial thickness. Maximum time of E2 exposure will be 14 days. Transvaginally scan to monitor endometrial development and to exclude the presence of a dominant follicle. Serial measurements of serum LH, estradiol and progesterone levels. Commence the initial progesterone dose of 100mg at 22hrs (vaginal suppository) after ≥ 7 days and ≤ 16 days of estradiol administration when the minimal endometrial thickness achieved is 6mm with a trilaminar appearance. Subsequently increase progesterone administration to 100mg vaginally three times daily. Continue estradiol administration 6mg (3 tablets daily).&#xD;
Blastocyst transfer is scheduled on the 5th full day of progesterone administration, following the initial initiation of progesterone.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Spontaneous natural cycles</arm_group_label>
    <description>Ultrasound scans to monitor follicular growth and serial measurements of serum LH, estradiol and progesterone levels to determine the timing of ovulation. The LH surge will be considered to have begun when the concentration rises by 180% above the most recent serum value and continues to rise thereafter.&#xD;
Day 1 after the LH rise, a decrease in estradiol concentration is identified. Twenty four hours later progesterone concentrations rise with a level of greater than or equal to 1.5ng/ml confirming ovulation (day 0). This is considered as day 0 with initiation of vaginal progesterone 100mg (vaginal suppository) at 2200H. The following day (day 1) increases progesterone administration to 100mg vaginally three times daily (8 hourly) and continues this regime until 7 weeks gestation as per clinic protocol.&#xD;
Embryo transfer is scheduled 5 days (day 5) following confirmation of ovulation (day 0).</description>
  </arm_group>
  <intervention>
    <intervention_type>Diagnostic Test</intervention_type>
    <intervention_name>Blood test</intervention_name>
    <description>Mesurement of E2, P4, LH, FSH hormones</description>
    <arm_group_label>Artificial (HRT) Cycles</arm_group_label>
    <arm_group_label>Spontaneous natural cycles</arm_group_label>
    <arm_group_label>Stimulated cycles</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Diagnostic Test</intervention_type>
    <intervention_name>Ultrasound</intervention_name>
    <description>Follicular measurement and endometrium measurement</description>
    <arm_group_label>Artificial (HRT) Cycles</arm_group_label>
    <arm_group_label>Spontaneous natural cycles</arm_group_label>
    <arm_group_label>Stimulated cycles</arm_group_label>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        Patients who are undergoing ovarian stimulation for IVF/ICSI with pre-implantation genetic&#xD;
        screening and embryo vitrification, who are planned for their first FET transfer cycle.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Women aged 18 years to 40 years with regular menses (26-34 days)&#xD;
&#xD;
          -  Having 1 or 2 chromosomally normal cryopreserved blastocysts available for transfer&#xD;
             after IVF / ICSI treatment&#xD;
&#xD;
          -  First frozen-thawed transfer cycle&#xD;
&#xD;
          -  Progesterone level &lt; 1.5 ng/mL day of trigger injection in stimulation cycle from&#xD;
             which embryos to be transferred were created.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Polycystic ovarian syndrome&#xD;
&#xD;
          -  Poor ovarian responder in accordance with Bologna criteria&#xD;
&#xD;
          -  Uterine abnormality US / saline infusion sonohysterogram&#xD;
&#xD;
          -  Previous dilatation &amp; curettage (D&amp;C)&#xD;
&#xD;
          -  Hydrosalpinx&#xD;
&#xD;
          -  Asherman syndrome&#xD;
&#xD;
          -  History of endometriosis AFS ≥ 2&#xD;
&#xD;
          -  ICSI due to severe male factor with testicular sperm&#xD;
&#xD;
          -  Any known contraindications or allergy to oral estradiol or progesterone.&#xD;
&#xD;
          -  Discontinuation of HRT medication ( medication error in research HRT cycle )&#xD;
&#xD;
          -  Failure to detect ovulation in the research natural cycle&#xD;
&#xD;
          -  Ovulation after day 20 in a natural cycle&#xD;
&#xD;
          -  Duration of estradiol exposure ≥ 17 days and endometrium &lt; 6mm&#xD;
&#xD;
          -  Spontaneous ovulation in HRT artificial cycle&#xD;
      </textblock>
    </criteria>
    <gender>Female</gender>
    <gender_based>Yes</gender_based>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>40 Years</maximum_age>
  </eligibility>
  <overall_official>
    <last_name>Barbara Lawrenz, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>IVI Middle East Fertility Clinic LLC</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>IVI Middle East Fertility Clinic</name>
      <address>
        <city>Abu Dhabi</city>
        <zip>60202</zip>
        <country>United Arab Emirates</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United Arab Emirates</country>
  </location_countries>
  <link>
    <url>http://www.gums.ac.ir/Upload/Modules/Contents/asset39/Clinical%20Gynecologic%20Endocrinology%20and%20Infertility%206.pdf</url>
    <description>Clinical Gynecologic Endocrinology and Infertility</description>
  </link>
  <results_reference>
    <citation>Bu Z, Sun Y. The Impact of Endometrial Thickness on the Day of Human Chorionic Gonadotrophin (hCG) Administration on Ongoing Pregnancy Rate in Patients with Different Ovarian Response. PLoS One. 2015 Dec 30;10(12):e0145703. doi: 10.1371/journal.pone.0145703. eCollection 2015.</citation>
    <PMID>26717148</PMID>
  </results_reference>
  <results_reference>
    <citation>Fatemi HM, Kyrou D, Bourgain C, Van den Abbeel E, Griesinger G, Devroey P. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril. 2010 Nov;94(6):2054-8. doi: 10.1016/j.fertnstert.2009.11.036. Epub 2010 Jan 25.</citation>
    <PMID>20097333</PMID>
  </results_reference>
  <results_reference>
    <citation>Haas J, Smith R, Zilberberg E, Nayot D, Meriano J, Barzilay E, Casper RF. Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers. Fertil Steril. 2019 Sep;112(3):503-509.e1. doi: 10.1016/j.fertnstert.2019.05.001. Epub 2019 Jun 24.</citation>
    <PMID>31248618</PMID>
  </results_reference>
  <results_reference>
    <citation>Irani M, Robles A, Gunnala V, Reichman D, Rosenwaks Z. Optimal parameters for determining the LH surge in natural cycle frozen-thawed embryo transfers. J Ovarian Res. 2017 Oct 16;10(1):70. doi: 10.1186/s13048-017-0367-7.</citation>
    <PMID>29037231</PMID>
  </results_reference>
  <results_reference>
    <citation>Kasius A, Smit JG, Torrance HL, Eijkemans MJ, Mol BW, Opmeer BC, Broekmans FJ. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis. Hum Reprod Update. 2014 Jul-Aug;20(4):530-41. doi: 10.1093/humupd/dmu011. Epub 2014 Mar 23.</citation>
    <PMID>24664156</PMID>
  </results_reference>
  <results_reference>
    <citation>La Marca A, Sunkara SK. Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice. Hum Reprod Update. 2014 Jan-Feb;20(1):124-40. doi: 10.1093/humupd/dmt037. Epub 2013 Sep 29.</citation>
    <PMID>24077980</PMID>
  </results_reference>
  <results_reference>
    <citation>Lawrenz B, Labarta E, Fatemi H, Bosch E. Premature progesterone elevation: targets and rescue strategies. Fertil Steril. 2018 Apr;109(4):577-582. doi: 10.1016/j.fertnstert.2018.02.128.</citation>
    <PMID>29653703</PMID>
  </results_reference>
  <results_reference>
    <citation>Liu KE, Hartman M, Hartman A, Luo ZC, Mahutte N. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: an analysis of over 40 000 embryo transfers. Hum Reprod. 2018 Oct 1;33(10):1883-1888. doi: 10.1093/humrep/dey281.</citation>
    <PMID>30239738</PMID>
  </results_reference>
  <results_reference>
    <citation>Liu Y, Ye XY, Chan C. The association between endometrial thickness and pregnancy outcome in gonadotropin-stimulated intrauterine insemination cycles. Reprod Biol Endocrinol. 2019 Jan 23;17(1):14. doi: 10.1186/s12958-019-0455-1.</citation>
    <PMID>30674305</PMID>
  </results_reference>
  <results_reference>
    <citation>Testart J, Frydman R, Feinstein MC, Thebault A, Roger M, Scholler R. Interpretation of plasma luteinizing hormone assay for the collection of mature oocytes from women: definition of a luteinizing hormone surge-initiating rise. Fertil Steril. 1981 Jul;36(1):50-4. doi: 10.1016/s0015-0282(16)45617-7.</citation>
    <PMID>7250407</PMID>
  </results_reference>
  <results_reference>
    <citation>Vaegter KK, Lakic TG, Olovsson M, Berglund L, Brodin T, Holte J. Which factors are most predictive for live birth after in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI) treatments? Analysis of 100 prospectively recorded variables in 8,400 IVF/ICSI single-embryo transfers. Fertil Steril. 2017 Mar;107(3):641-648.e2. doi: 10.1016/j.fertnstert.2016.12.005. Epub 2017 Jan 17.</citation>
    <PMID>28108009</PMID>
  </results_reference>
  <results_reference>
    <citation>Yuan X, Saravelos SH, Wang Q, Xu Y, Li TC, Zhou C. Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF-ICSI cycles. Reprod Biomed Online. 2016 Aug;33(2):197-205. doi: 10.1016/j.rbmo.2016.05.002. Epub 2016 May 13.</citation>
    <PMID>27238372</PMID>
  </results_reference>
  <results_reference>
    <citation>Zhao J, Zhang Q, Wang Y, Li Y. Endometrial pattern, thickness and growth in predicting pregnancy outcome following 3319 IVF cycle. Reprod Biomed Online. 2014 Sep;29(3):291-8. doi: 10.1016/j.rbmo.2014.05.011. Epub 2014 Jun 13.</citation>
    <PMID>25070912</PMID>
  </results_reference>
  <verification_date>March 2021</verification_date>
  <study_first_submitted>June 28, 2020</study_first_submitted>
  <study_first_submitted_qc>June 28, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 1, 2020</study_first_posted>
  <last_update_submitted>March 4, 2021</last_update_submitted>
  <last_update_submitted_qc>March 4, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">March 8, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>ART Fertility Clinics LLC</investigator_affiliation>
    <investigator_full_name>Barbara Lawrenz</investigator_full_name>
    <investigator_title>Scientific Director</investigator_title>
  </responsible_party>
  <keyword>infertilty</keyword>
  <keyword>progesterone</keyword>
  <keyword>endometrium</keyword>
  <keyword>pregnancy</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Infertility</mesh_term>
    <mesh_term>Infertility, Female</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04454749
org study id: 2003-ABU-002-BL
nct id: NCT04454749
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
For a pregnancy to occur, an euploid embryo at blastocyst developmental stage, a receptive
      endometrium and the synchrony of both is crucial. Many studies lately investigated the
      influence of the endometrial thickness and pattern on the artificial reproductive technology
      (ART) outcome, however, with conflicting results.
Further on, the measurement of the endometrial thickness was mostly performed either on the
      day of final oocyte maturation in stimulated cycles with fresh embryo transfer or on the day
      of progesterone administration in FET cycles.

      Progesterone is essential for the secretory transformation and compaction of the endometrium,
      prior to implantation. A recently published paper (Haas et al., 2019) however, evaluated the
      degree of endometrial compaction under the influence of progesterone in FET cycles and
      described, that a lack of certain endometrial compaction has a negative impact on the ongoing
      pregnancy rate. As in this study embryos of unknown ploidy status were transferred, the role
      of embryo ploidy on the outcome may bias the study results.

      In the herein presented study protocol we aim to investigate the influence of endometrial
      compaction in FET cycles in which euploid embryos are transferred.

      HYPOTHESIS: Lack of endometrial compaction after the start of progesterone leads to an
      impaired reproductive outcome.
observational model: Cohort
time perspective: Prospective
measure: Ongoing pregnancy rate
time frame: 12 weeks
description: Ongoing pregnancy rate (≥ 12 weeks) in patients with endometrial compaction compared to patients without endometrial compaction after frozen embryo transfer of 1 or 2 euploid blastocysts
measure: Biochemical pregnancy rate in HRT cycle
time frame: 5 weeks
description: Positive hCG, but at 5 gestational weeks no ultrasonographic visible gestational sac seen after embryo transfer in HRT-FET cycles with one or two euploid embryos, depending on the degree of compaction.
measure: Biochemical pregnancy rate in spontaneous cycle
time frame: 5 weeks
description: positive hCG, but at 5 gestational weeks no ultrasonographic visible gestational sac seen) after embryo transfer in NC-FET cycles with one or two euploid embryos, depending on the degree of compaction.
measure: Clinical implantation rate in HRT cycle
time frame: 6 weeks
description: Number of gestational sacs observed by ultrasound at 6 weeks of gestation divided by the number of embryos transferred), defined by a ß-hCG of > 5 IU on day 12 after embryo transfer in HRT-FET cycles with one or two euploid embryos, depending on the degree of compaction
measure: Clinical implantation rate in spontaneous cycle
time frame: 6 weeks
description: Number of gestational sacs observed by ultrasound at 6 weeks of gestation divided by the number of embryos transferred), defined by a ß-hCG of > 5 IU on day 12 after embryo transfer in NC-FET cycles with one or two euploid embryos, depending on the degree of compaction.
arm group label: Stimulated cycles
description: Ovarian stimulation will be performed by standard protocols. Stimulation medication dosage will be individualised prior to stimulation start according to the ovarian reserve parameters and during ovarian stimulation according to the ovarian response and the measured levels of E2 and progesterone (P4), in order to avoid progesterone elevation during late follicular phase. Final oocyte maturation will be achieved by administration of either 10.000 IU of hCG, 0.3 mg of GnRH agonist (Triptorelin) or dual trigger (hCG and GnRH-analogue), as soon as ≥ 3 follicles ≥ 17 mm are present. Oocyte retrieval will be carried out 36 hours after administration of the trigger. Embryos will undergo PGT-A at blastocyst stage and be vitrified thereafter.
arm group label: Artificial (HRT) Cycles
description: Start of estradiol valerate 4mg on day 2 of the cycle for three days. Increase E2 to 6mg on day 4 of E2 treatment. E2 dose may be increased according to clinician discretion based on endometrial thickness. Maximum time of E2 exposure will be 14 days. Transvaginally scan to monitor endometrial development and to exclude the presence of a dominant follicle. Serial measurements of serum LH, estradiol and progesterone levels. Commence the initial progesterone dose of 100mg at 22hrs (vaginal suppository) after ≥ 7 days and ≤ 16 days of estradiol administration when the minimal endometrial thickness achieved is 6mm with a trilaminar appearance. Subsequently increase progesterone administration to 100mg vaginally three times daily. Continue estradiol administration 6mg (3 tablets daily).
Blastocyst transfer is scheduled on the 5th full day of progesterone administration, following the initial initiation of progesterone.
arm group label: Spontaneous natural cycles
description: Ultrasound scans to monitor follicular growth and serial measurements of serum LH, estradiol and progesterone levels to determine the timing of ovulation. The LH surge will be considered to have begun when the concentration rises by 180% above the most recent serum value and continues to rise thereafter.
Day 1 after the LH rise, a decrease in estradiol concentration is identified. Twenty four hours later progesterone concentrations rise with a level of greater than or equal to 1.5ng/ml confirming ovulation (day 0). This is considered as day 0 with initiation of vaginal progesterone 100mg (vaginal suppository) at 2200H. The following day (day 1) increases progesterone administration to 100mg vaginally three times daily (8 hourly) and continues this regime until 7 weeks gestation as per clinic protocol.
Embryo transfer is scheduled 5 days (day 5) following confirmation of ovulation (day 0).
intervention type: Diagnostic Test
intervention name: Blood test
description: Mesurement of E2, P4, LH, FSH hormones
arm group label: Artificial (HRT) Cycles
arm group label: Spontaneous natural cycles
arm group label: Stimulated cycles
intervention type: Diagnostic Test
intervention name: Ultrasound
description: Follicular measurement and endometrium measurement
arm group label: Artificial (HRT) Cycles
arm group label: Spontaneous natural cycles
arm group label: Stimulated cycles
study pop: 
sampling method: Probability Sample
criteria: 
gender: Female
gender based: Yes
minimum age: 18 Years
maximum age: 40 Years
last name: Barbara Lawrenz, PhD
role: Principal Investigator
affiliation: IVI Middle East Fertility Clinic LLC
facility: 
country: United Arab Emirates
url: http://www.gums.ac.ir/Upload/Modules/Contents/asset39/Clinical%20Gynecologic%20Endocrinology%20and%20Infertility%206.pdf
description: Clinical Gynecologic Endocrinology and Infertility
citation: Bu Z, Sun Y. The Impact of Endometrial Thickness on the Day of Human Chorionic Gonadotrophin (hCG) Administration on Ongoing Pregnancy Rate in Patients with Different Ovarian Response. PLoS One. 2015 Dec 30;10(12):e0145703. doi: 10.1371/journal.pone.0145703. eCollection 2015.
PMID: 26717148
citation: Fatemi HM, Kyrou D, Bourgain C, Van den Abbeel E, Griesinger G, Devroey P. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril. 2010 Nov;94(6):2054-8. doi: 10.1016/j.fertnstert.2009.11.036. Epub 2010 Jan 25.
PMID: 20097333
citation: Haas J, Smith R, Zilberberg E, Nayot D, Meriano J, Barzilay E, Casper RF. Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers. Fertil Steril. 2019 Sep;112(3):503-509.e1. doi: 10.1016/j.fertnstert.2019.05.001. Epub 2019 Jun 24.
PMID: 31248618
citation: Irani M, Robles A, Gunnala V, Reichman D, Rosenwaks Z. Optimal parameters for determining the LH surge in natural cycle frozen-thawed embryo transfers. J Ovarian Res. 2017 Oct 16;10(1):70. doi: 10.1186/s13048-017-0367-7.
PMID: 29037231
citation: Kasius A, Smit JG, Torrance HL, Eijkemans MJ, Mol BW, Opmeer BC, Broekmans FJ. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis. Hum Reprod Update. 2014 Jul-Aug;20(4):530-41. doi: 10.1093/humupd/dmu011. Epub 2014 Mar 23.
PMID: 24664156
citation: La Marca A, Sunkara SK. Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice. Hum Reprod Update. 2014 Jan-Feb;20(1):124-40. doi: 10.1093/humupd/dmt037. Epub 2013 Sep 29.
PMID: 24077980
citation: Lawrenz B, Labarta E, Fatemi H, Bosch E. Premature progesterone elevation: targets and rescue strategies. Fertil Steril. 2018 Apr;109(4):577-582. doi: 10.1016/j.fertnstert.2018.02.128.
PMID: 29653703
citation: Liu KE, Hartman M, Hartman A, Luo ZC, Mahutte N. The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: an analysis of over 40 000 embryo transfers. Hum Reprod. 2018 Oct 1;33(10):1883-1888. doi: 10.1093/humrep/dey281.
PMID: 30239738
citation: Liu Y, Ye XY, Chan C. The association between endometrial thickness and pregnancy outcome in gonadotropin-stimulated intrauterine insemination cycles. Reprod Biol Endocrinol. 2019 Jan 23;17(1):14. doi: 10.1186/s12958-019-0455-1.
PMID: 30674305
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responsible party type: Principal Investigator
investigator affiliation: ART Fertility Clinics LLC
investigator full name: Barbara Lawrenz
investigator title: Scientific Director
mesh term: Infertility
mesh term: Infertility, Female
sharing ipd: Undecided