<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04417569</url>
  </required_header>
  <id_info>
    <org_study_id>2002-ABU-001-CC</org_study_id>
    <nct_id>NCT04417569</nct_id>
  </id_info>
  <brief_title>A Proof of Concept Study of Serum Progesterone Levels for IVF/ICSI Following HCG Trigger for Oocyte Maturation</brief_title>
  <official_title>A Proof of Concept Study to Determine the Rise of Progesterone Levels After Human Chorionic Gonadotrophin (hCG) Trigger in Stimulated Cycles of IVF/ICSI</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>ART Fertility Clinics LLC</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>ART Fertility Clinics LLC</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This study will determine the rise of progesterone levels after human chorionic gonadotrophin&#xD;
      (hCG) trigger in stimulated cycles IVF/ICSI&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Studies have suggested that controlled ovarian hyperstimulation adversely affects endometrial&#xD;
      receptivity. In ovarian stimulation cycles with exogenous gonadotrophins there is an ongoing&#xD;
      debate regarding the effect of a late follicular phase progesterone level on reproductive&#xD;
      outcomes. It is not yet clarified if an elevated serum progesterone level in the late&#xD;
      follicular phase is a symptom or cause of an adverse effect on reproductive outcomes. A new&#xD;
      hypothesis is evolving and gaining momentum providing a novel explanation for the association&#xD;
      between late follicular phase progesterone rise and reproductive outcome. It is proposed that&#xD;
      exogenous FSH (Follicle-stimulating hormone) administration results in supraphysiological&#xD;
      levels of FSH, which induce an abundance of LH (luteinizing hormone) receptors on granulosa&#xD;
      cells causing the follicles to become hypersensitive to LH-like activity (ie hCG trigger).&#xD;
      Based on this hypothesis, the focus should be placed on the hCG trigger rather than on the&#xD;
      late follicular phase progesterone rise.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">February 4, 2021</start_date>
  <completion_date type="Actual">June 30, 2021</completion_date>
  <primary_completion_date type="Actual">May 26, 2021</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Only</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Level of progesterone day of trigger</measure>
    <time_frame>1 day</time_frame>
    <description>day of the hCG trigger between 1000h - 1200h, before trigger, 1 hour after trigger, 2 hrs after trigger</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Level of progesterone day of egg retrieval</measure>
    <time_frame>1 day</time_frame>
    <description>36hrs after trigger</description>
  </secondary_outcome>
  <number_of_groups>1</number_of_groups>
  <enrollment type="Actual">10</enrollment>
  <condition>Infertility</condition>
  <condition>Infertility, Female</condition>
  <condition>IVF</condition>
  <condition>hCG</condition>
  <arm_group>
    <arm_group_label>stimulated cycles</arm_group_label>
    <description>Patients will have blood drawn on five separate occasions: before and following hCG trigger on the day of final oocyte maturation and day of egg collection</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>hCG</intervention_name>
    <description>human chorionic gonadotropin</description>
    <arm_group_label>stimulated cycles</arm_group_label>
    <other_name>human chorionic gonadotropin</other_name>
  </intervention>
  <intervention>
    <intervention_type>Diagnostic Test</intervention_type>
    <intervention_name>Ultrasound</intervention_name>
    <description>Endometrial thickness monitoring</description>
    <arm_group_label>stimulated cycles</arm_group_label>
    <other_name>transvaginal scan</other_name>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Blood test</intervention_name>
    <description>Progesterone, Luteinizing Hormone, Estradiol</description>
    <arm_group_label>stimulated cycles</arm_group_label>
    <other_name>Progesterone, Luteinizing Hormone, Estradiol</other_name>
  </intervention>
  <biospec_retention>Samples With DNA</biospec_retention>
  <biospec_descr>
    <textblock>
      Blood sample&#xD;
    </textblock>
  </biospec_descr>
  <eligibility>
    <study_pop>
      <textblock>
        Female patients who are planned to commence ovarian stimulation for IVF/ICSI with hCG&#xD;
        trigger for oocyte maturation and plan to avail of pre-implantation genetic screening with&#xD;
        embryo vitrification of their biopsied embryos at blastocyst stage&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Females aged 18 to 42 years with regular menstrual cycles of 26-34 days&#xD;
&#xD;
          -  Undergoing ovarian stimulation for IVF/ICSI &amp; PGS.&#xD;
&#xD;
          -  Receiving recombinant FSH for stimulation&#xD;
&#xD;
          -  hCG 5000iu IM as trigger injection for oocyte maturation.&#xD;
&#xD;
          -  Ovarian stimulation in GnRH-antagonist protocols&#xD;
&#xD;
          -  BMI 18- 35 kg/m2&#xD;
&#xD;
          -  Having 1 or 2 euploid embryos for transfer in spontaneous natural cycles.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Poor ovarian reserve as defined by Bologna criteria&#xD;
&#xD;
          -  PCOS in accordance with Rotterdam criteria&#xD;
      </textblock>
    </criteria>
    <gender>Female</gender>
    <gender_based>Yes</gender_based>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>42 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Raquel Loja Vitorino, Specialist</last_name>
    <role>Principal Investigator</role>
    <affiliation>ART Fertility Clinics LLC</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>ART Fertility Clinics LLC</name>
      <address>
        <city>Abu Dhabi</city>
        <zip>60202</zip>
        <country>United Arab Emirates</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United Arab Emirates</country>
  </location_countries>
  <results_reference>
    <citation>Bourgain C, Devroey P. The endometrium in stimulated cycles for IVF. Hum Reprod Update. 2003 Nov-Dec;9(6):515-22. doi: 10.1093/humupd/dmg045.</citation>
    <PMID>14714588</PMID>
  </results_reference>
  <results_reference>
    <citation>Devroey P, Bourgain C, Macklon NS, Fauser BC. Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab. 2004 Mar;15(2):84-90. doi: 10.1016/j.tem.2004.01.009.</citation>
    <PMID>15036255</PMID>
  </results_reference>
  <results_reference>
    <citation>Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, Devroey P. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril. 2002 Nov;78(5):1025-9. doi: 10.1016/s0015-0282(02)03323-x.</citation>
    <PMID>12413988</PMID>
  </results_reference>
  <results_reference>
    <citation>Nikas G, Develioglu OH, Toner JP, Jones HW Jr. Endometrial pinopodes indicate a shift in the window of receptivity in IVF cycles. Hum Reprod. 1999 Mar;14(3):787-92. doi: 10.1093/humrep/14.3.787.</citation>
    <PMID>10221715</PMID>
  </results_reference>
  <results_reference>
    <citation>Simon C, Garcia Velasco JJ, Valbuena D, Peinado JA, Moreno C, Remohi J, Pellicer A. Increasing uterine receptivity by decreasing estradiol levels during the preimplantation period in high responders with the use of a follicle-stimulating hormone step-down regimen. Fertil Steril. 1998 Aug;70(2):234-9. doi: 10.1016/s0015-0282(98)00140-x.</citation>
    <PMID>9696213</PMID>
  </results_reference>
  <results_reference>
    <citation>Weinerman R, Mainigi M. Why we should transfer frozen instead of fresh embryos: the translational rationale. Fertil Steril. 2014 Jul;102(1):10-8. doi: 10.1016/j.fertnstert.2014.05.019. Epub 2014 Jun 2.</citation>
    <PMID>24890274</PMID>
  </results_reference>
  <results_reference>
    <citation>Liu Y, Lee KF, Ng EH, Yeung WS, Ho PC. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64. doi: 10.1016/j.fertnstert.2007.10.020. Epub 2008 Jan 14.</citation>
    <PMID>18191855</PMID>
  </results_reference>
  <results_reference>
    <citation>Haouzi D, Assou S, Mahmoud K, Tondeur S, Reme T, Hedon B, De Vos J, Hamamah S. Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients. Hum Reprod. 2009 Jun;24(6):1436-45. doi: 10.1093/humrep/dep039. Epub 2009 Feb 26.</citation>
    <PMID>19246470</PMID>
  </results_reference>
  <results_reference>
    <citation>Roque M, Lattes K, Serra S, Sola I, Geber S, Carreras R, Checa MA. Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. Fertil Steril. 2013 Jan;99(1):156-162. doi: 10.1016/j.fertnstert.2012.09.003. Epub 2012 Oct 3.</citation>
    <PMID>23040524</PMID>
  </results_reference>
  <results_reference>
    <citation>Roque M, Valle M, Guimaraes F, Sampaio M, Geber S. Freeze-all policy: fresh vs. frozen-thawed embryo transfer. Fertil Steril. 2015 May;103(5):1190-3. doi: 10.1016/j.fertnstert.2015.01.045. Epub 2015 Mar 4.</citation>
    <PMID>25747130</PMID>
  </results_reference>
  <results_reference>
    <citation>Haas J, Smith R, Zilberberg E, Nayot D, Meriano J, Barzilay E, Casper RF. Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers. Fertil Steril. 2019 Sep;112(3):503-509.e1. doi: 10.1016/j.fertnstert.2019.05.001. Epub 2019 Jun 24.</citation>
    <PMID>31248618</PMID>
  </results_reference>
  <results_reference>
    <citation>Testart J, Frydman R, Feinstein MC, Thebault A, Roger M, Scholler R. Interpretation of plasma luteinizing hormone assay for the collection of mature oocytes from women: definition of a luteinizing hormone surge-initiating rise. Fertil Steril. 1981 Jul;36(1):50-4. doi: 10.1016/s0015-0282(16)45617-7.</citation>
    <PMID>7250407</PMID>
  </results_reference>
  <results_reference>
    <citation>Irani M, Robles A, Gunnala V, Reichman D, Rosenwaks Z. Optimal parameters for determining the LH surge in natural cycle frozen-thawed embryo transfers. J Ovarian Res. 2017 Oct 16;10(1):70. doi: 10.1186/s13048-017-0367-7.</citation>
    <PMID>29037231</PMID>
  </results_reference>
  <results_reference>
    <citation>Groenewoud ER, Macklon NS, Cohlen BJ; ANTARCTICA Study Group. The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles. Reprod Biomed Online. 2017 May;34(5):546-554. doi: 10.1016/j.rbmo.2017.02.008. Epub 2017 Feb 28.</citation>
    <PMID>28319018</PMID>
  </results_reference>
  <results_reference>
    <citation>Fatemi HM, Kyrou D, Bourgain C, Van den Abbeel E, Griesinger G, Devroey P. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril. 2010 Nov;94(6):2054-8. doi: 10.1016/j.fertnstert.2009.11.036. Epub 2010 Jan 25.</citation>
    <PMID>20097333</PMID>
  </results_reference>
  <results_reference>
    <citation>Bosch E, Labarta E, Crespo J, Simon C, Remohi J, Jenkins J, Pellicer A. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010 Aug;25(8):2092-100. doi: 10.1093/humrep/deq125. Epub 2010 Jun 10.</citation>
    <PMID>20539042</PMID>
  </results_reference>
  <results_reference>
    <citation>Griesinger G, Mannaerts B, Andersen CY, Witjes H, Kolibianakis EM, Gordon K. Progesterone elevation does not compromise pregnancy rates in high responders: a pooled analysis of in vitro fertilization patients treated with recombinant follicle-stimulating hormone/gonadotropin-releasing hormone antagonist in six trials. Fertil Steril. 2013 Dec;100(6):1622-8.e1-3. doi: 10.1016/j.fertnstert.2013.08.045. Epub 2013 Sep 29.</citation>
    <PMID>24083873</PMID>
  </results_reference>
  <results_reference>
    <citation>Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update. 2013 Sep-Oct;19(5):433-57. doi: 10.1093/humupd/dmt014. Epub 2013 Jul 4.</citation>
    <PMID>23827986</PMID>
  </results_reference>
  <results_reference>
    <citation>Yding Andersen C, Bungum L, Nyboe Andersen A, Humaidan P. Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate. Reprod Biomed Online. 2011 Aug;23(2):187-95. doi: 10.1016/j.rbmo.2011.04.003. Epub 2011 Apr 28.</citation>
    <PMID>21665546</PMID>
  </results_reference>
  <results_reference>
    <citation>Friis Wang N, Skouby SO, Humaidan P, Andersen CY. Response to ovulation trigger is correlated to late follicular phase progesterone levels: A hypothesis explaining reduced reproductive outcomes caused by increased late follicular progesterone rise. Hum Reprod. 2019 May 1;34(5):942-948. doi: 10.1093/humrep/dez023.</citation>
    <PMID>30927415</PMID>
  </results_reference>
  <verification_date>February 2022</verification_date>
  <study_first_submitted>May 18, 2020</study_first_submitted>
  <study_first_submitted_qc>June 3, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 4, 2020</study_first_posted>
  <last_update_submitted>February 17, 2022</last_update_submitted>
  <last_update_submitted_qc>February 17, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">February 18, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Infertility</mesh_term>
    <mesh_term>Infertility, Female</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Chorionic Gonadotropin</mesh_term>
    <mesh_term>Estradiol</mesh_term>
    <mesh_term>Progesterone</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04417569
org study id: 2002-ABU-001-CC
nct id: NCT04417569
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
This study will determine the rise of progesterone levels after human chorionic gonadotrophin
      (hCG) trigger in stimulated cycles IVF/ICSI
Studies have suggested that controlled ovarian hyperstimulation adversely affects endometrial
      receptivity. In ovarian stimulation cycles with exogenous gonadotrophins there is an ongoing
      debate regarding the effect of a late follicular phase progesterone level on reproductive
      outcomes. It is not yet clarified if an elevated serum progesterone level in the late
      follicular phase is a symptom or cause of an adverse effect on reproductive outcomes. A new
      hypothesis is evolving and gaining momentum providing a novel explanation for the association
      between late follicular phase progesterone rise and reproductive outcome. It is proposed that
      exogenous FSH (Follicle-stimulating hormone) administration results in supraphysiological
      levels of FSH, which induce an abundance of LH (luteinizing hormone) receptors on granulosa
      cells causing the follicles to become hypersensitive to LH-like activity (ie hCG trigger).
      Based on this hypothesis, the focus should be placed on the hCG trigger rather than on the
      late follicular phase progesterone rise.
observational model: Case-Only
time perspective: Prospective
measure: Level of progesterone day of trigger
time frame: 1 day
description: day of the hCG trigger between 1000h - 1200h, before trigger, 1 hour after trigger, 2 hrs after trigger
measure: Level of progesterone day of egg retrieval
time frame: 1 day
description: 36hrs after trigger
arm group label: stimulated cycles
description: Patients will have blood drawn on five separate occasions: before and following hCG trigger on the day of final oocyte maturation and day of egg collection
intervention type: Drug
intervention name: hCG
description: human chorionic gonadotropin
arm group label: stimulated cycles
other name: human chorionic gonadotropin
intervention type: Diagnostic Test
intervention name: Ultrasound
description: Endometrial thickness monitoring
arm group label: stimulated cycles
other name: transvaginal scan
intervention type: Other
intervention name: Blood test
description: Progesterone, Luteinizing Hormone, Estradiol
arm group label: stimulated cycles
other name: Progesterone, Luteinizing Hormone, Estradiol
Blood sample
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: Female
gender based: Yes
minimum age: 18 Years
maximum age: 42 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Raquel Loja Vitorino, Specialist
role: Principal Investigator
affiliation: ART Fertility Clinics LLC
facility: 
country: United Arab Emirates
citation: Bourgain C, Devroey P. The endometrium in stimulated cycles for IVF. Hum Reprod Update. 2003 Nov-Dec;9(6):515-22. doi: 10.1093/humupd/dmg045.
PMID: 14714588
citation: Devroey P, Bourgain C, Macklon NS, Fauser BC. Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab. 2004 Mar;15(2):84-90. doi: 10.1016/j.tem.2004.01.009.
PMID: 15036255
citation: Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, Devroey P. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril. 2002 Nov;78(5):1025-9. doi: 10.1016/s0015-0282(02)03323-x.
PMID: 12413988
citation: Nikas G, Develioglu OH, Toner JP, Jones HW Jr. Endometrial pinopodes indicate a shift in the window of receptivity in IVF cycles. Hum Reprod. 1999 Mar;14(3):787-92. doi: 10.1093/humrep/14.3.787.
PMID: 10221715
citation: Simon C, Garcia Velasco JJ, Valbuena D, Peinado JA, Moreno C, Remohi J, Pellicer A. Increasing uterine receptivity by decreasing estradiol levels during the preimplantation period in high responders with the use of a follicle-stimulating hormone step-down regimen. Fertil Steril. 1998 Aug;70(2):234-9. doi: 10.1016/s0015-0282(98)00140-x.
PMID: 9696213
citation: Weinerman R, Mainigi M. Why we should transfer frozen instead of fresh embryos: the translational rationale. Fertil Steril. 2014 Jul;102(1):10-8. doi: 10.1016/j.fertnstert.2014.05.019. Epub 2014 Jun 2.
PMID: 24890274
citation: Liu Y, Lee KF, Ng EH, Yeung WS, Ho PC. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64. doi: 10.1016/j.fertnstert.2007.10.020. Epub 2008 Jan 14.
PMID: 18191855
citation: Haouzi D, Assou S, Mahmoud K, Tondeur S, Reme T, Hedon B, De Vos J, Hamamah S. Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients. Hum Reprod. 2009 Jun;24(6):1436-45. doi: 10.1093/humrep/dep039. Epub 2009 Feb 26.
PMID: 19246470
citation: Roque M, Lattes K, Serra S, Sola I, Geber S, Carreras R, Checa MA. Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. Fertil Steril. 2013 Jan;99(1):156-162. doi: 10.1016/j.fertnstert.2012.09.003. Epub 2012 Oct 3.
PMID: 23040524
citation: Roque M, Valle M, Guimaraes F, Sampaio M, Geber S. Freeze-all policy: fresh vs. frozen-thawed embryo transfer. Fertil Steril. 2015 May;103(5):1190-3. doi: 10.1016/j.fertnstert.2015.01.045. Epub 2015 Mar 4.
PMID: 25747130
citation: Haas J, Smith R, Zilberberg E, Nayot D, Meriano J, Barzilay E, Casper RF. Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen-thawed embryo transfers. Fertil Steril. 2019 Sep;112(3):503-509.e1. doi: 10.1016/j.fertnstert.2019.05.001. Epub 2019 Jun 24.
PMID: 31248618
citation: Testart J, Frydman R, Feinstein MC, Thebault A, Roger M, Scholler R. Interpretation of plasma luteinizing hormone assay for the collection of mature oocytes from women: definition of a luteinizing hormone surge-initiating rise. Fertil Steril. 1981 Jul;36(1):50-4. doi: 10.1016/s0015-0282(16)45617-7.
PMID: 7250407
citation: Irani M, Robles A, Gunnala V, Reichman D, Rosenwaks Z. Optimal parameters for determining the LH surge in natural cycle frozen-thawed embryo transfers. J Ovarian Res. 2017 Oct 16;10(1):70. doi: 10.1186/s13048-017-0367-7.
PMID: 29037231
citation: Groenewoud ER, Macklon NS, Cohlen BJ; ANTARCTICA Study Group. The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles. Reprod Biomed Online. 2017 May;34(5):546-554. doi: 10.1016/j.rbmo.2017.02.008. Epub 2017 Feb 28.
PMID: 28319018
citation: Fatemi HM, Kyrou D, Bourgain C, Van den Abbeel E, Griesinger G, Devroey P. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril. 2010 Nov;94(6):2054-8. doi: 10.1016/j.fertnstert.2009.11.036. Epub 2010 Jan 25.
PMID: 20097333
citation: Bosch E, Labarta E, Crespo J, Simon C, Remohi J, Jenkins J, Pellicer A. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010 Aug;25(8):2092-100. doi: 10.1093/humrep/deq125. Epub 2010 Jun 10.
PMID: 20539042
citation: Griesinger G, Mannaerts B, Andersen CY, Witjes H, Kolibianakis EM, Gordon K. Progesterone elevation does not compromise pregnancy rates in high responders: a pooled analysis of in vitro fertilization patients treated with recombinant follicle-stimulating hormone/gonadotropin-releasing hormone antagonist in six trials. Fertil Steril. 2013 Dec;100(6):1622-8.e1-3. doi: 10.1016/j.fertnstert.2013.08.045. Epub 2013 Sep 29.
PMID: 24083873
citation: Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update. 2013 Sep-Oct;19(5):433-57. doi: 10.1093/humupd/dmt014. Epub 2013 Jul 4.
PMID: 23827986
citation: Yding Andersen C, Bungum L, Nyboe Andersen A, Humaidan P. Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate. Reprod Biomed Online. 2011 Aug;23(2):187-95. doi: 10.1016/j.rbmo.2011.04.003. Epub 2011 Apr 28.
PMID: 21665546
citation: Friis Wang N, Skouby SO, Humaidan P, Andersen CY. Response to ovulation trigger is correlated to late follicular phase progesterone levels: A hypothesis explaining reduced reproductive outcomes caused by increased late follicular progesterone rise. Hum Reprod. 2019 May 1;34(5):942-948. doi: 10.1093/humrep/dez023.
PMID: 30927415
responsible party type: Sponsor
mesh term: Infertility
mesh term: Infertility, Female
mesh term: Chorionic Gonadotropin
mesh term: Estradiol
mesh term: Progesterone
sharing ipd: Undecided