<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04490993</url>
  </required_header>
  <id_info>
    <org_study_id>YHCT-NIT-R1</org_study_id>
    <nct_id>NCT04490993</nct_id>
  </id_info>
  <brief_title>Safety and Efficacy of APL-1202 in Combination With Epirubicin Hydrochloride Versus Epirubicin Hydrochloride Alone in Intermediate and High-risk Chemo-refractory Non-muscle Invasive Bladder Cancer (NMIBC) Patients</brief_title>
  <acronym>ACCRUE</acronym>
  <official_title>A Multi-center, Randomized, Double-blind, Placebo-controlled Phase Ⅲ Clinical Trial to Evaluate the Clinical Safety and Efficacy of APL-1202 in Combination With Epirubicin Hydrochloride Versus Epirubicin Hydrochloride Alone in Intermediate and High-risk Chemo-refractory Non-muscle Invasive Bladder Cancer (NMIBC) Patients</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Jiangsu Yahong Meditech Co., Ltd aka Asieris</agency>
      <agency_class>Industry</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Jiangsu Yahong Meditech Co., Ltd aka Asieris</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>Yes</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      To evaluate the clinical efficacy (median event-free survival) of APL-1202 in combination&#xD;
      with Epirubicin hydrochloride versus Epirubicin hydrochloride alone in intermediate and&#xD;
      high-risk chemo-refractory non-muscle invasive bladder cancer (NMIBC) patients&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      A multi-center, randomized, double-blind, placebo controlled Phase Ⅲ trial; including 3&#xD;
      stages: screening period, treatment period, and follow-up period.&#xD;
&#xD;
        -  Screening period: 6 weeks prior to treatment&#xD;
&#xD;
        -  Treatment period:&#xD;
&#xD;
        -  Induction period: APL-1202 is administered for 12 consecutive weeks&#xD;
&#xD;
        -  Maintenance period: after 12-week drug free period, APL-1202 is administered for&#xD;
           another12 consecutive weeks as maintenance treatment&#xD;
&#xD;
        -  Follow up period: APL-1202 is administered at every 3-month interval if no events&#xD;
           occurred in the treatment period and until the occurrence of events or the end of the&#xD;
           entire clinical trial Intravesical Epirubicin hydrochloride will be administered once&#xD;
           weekly for consecutive 6-8 weeks in the induction period, followed by once monthly in&#xD;
           the maintenance period until end of 12 months&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Active, not recruiting</overall_status>
  <start_date type="Actual">March 30, 2017</start_date>
  <completion_date type="Anticipated">May 30, 2022</completion_date>
  <primary_completion_date type="Anticipated">May 30, 2022</primary_completion_date>
  <phase>Phase 3</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Event-free survival</measure>
    <time_frame>Up to 30 months</time_frame>
    <description>&quot;Event&quot;is defined as: pathologically confirmed recurrence, progression, or death resulting from bladder cancer</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Recurrent-free rate</measure>
    <time_frame>24 months</time_frame>
    <description>Recurrent-free rate</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Progression-free rate</measure>
    <time_frame>24 months</time_frame>
    <description>Progression-free rate</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Clinical benefit rate at 12,18, 24 months after enrollment (clinical benefits are defined as the pathological improvement of the recurrence, no high-risk recurrence, progression-free recurrence, no radical therapy and no death)</measure>
    <time_frame>24 months</time_frame>
    <description>Clinical benefit rate at 12,18, 24 months after enrollment (clinical benefits are defined as the pathological improvement of the recurrence, no high-risk recurrence, progression-free recurrence, no radical therapy and no death)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Recurrence-free survival</measure>
    <time_frame>Up to 30 months</time_frame>
    <description>Recurrence-free survival</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Progression-free survival</measure>
    <time_frame>Up to 30 months</time_frame>
    <description>Progression-free survival</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Total survival</measure>
    <time_frame>Up to 30 months</time_frame>
    <description>Total survival</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">359</enrollment>
  <condition>Non-muscle Invasive Bladder Cancer</condition>
  <arm_group>
    <arm_group_label>APL-1202 treatment</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
  </arm_group>
  <arm_group>
    <arm_group_label>Placebo</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>APL-1202 in combination with Epirubicin</intervention_name>
    <description>Induction period: APL-1202 is administered for 12 consecutive weeks&#xD;
Maintenance period: after 12-week drug free period, APL-1202 is administered for another12 consecutive weeks as maintenance treatment&#xD;
Follow up period: APL-1202 is administered at every 3-month interval if no events occurred in the treatment period and until the occurrence of events or the end of the entire clinical trial Intravesical Epirubicin hydrochloride will be administered once weekly for consecutive 6-8 weeks in the induction period, followed by once monthly in the maintenance period until end of 12 months</description>
    <arm_group_label>APL-1202 treatment</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Placebo in combination with Epirubicin</intervention_name>
    <description>Induction period: placebo is administered for 12 consecutive weeks&#xD;
Maintenance period: after 12-week drug free period, placebo is administered for another12 consecutive weeks as maintenance treatment&#xD;
Follow up period: APL-1202 is administered at every 3-month interval if no events occurred in the treatment period and until the occurrence of events or the end of the entire clinical trial Intravesical Epirubicin hydrochloride will be administered once weekly for consecutive 6-8 weeks in the induction period, followed by once monthly in the maintenance period until end of 12 months</description>
    <arm_group_label>Placebo</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Must be informed of the investigational nature of this study and must provide written&#xD;
             informed consent&#xD;
&#xD;
          -  Age ≥18 years, male or female&#xD;
&#xD;
          -  Must have clinically and histologically confirmed recurrent intermediate and high-risk&#xD;
             non-muscle invasive transitional cell carcinoma of the bladder after treatment with&#xD;
             intravesical chemotherapy. EORTC risk score (according to EUA &quot;NMIBC Guideline&quot; 2015&#xD;
             version) must be ≥ 5: Papilloma alone (or with Cis) or Cis alone No visible tumor&#xD;
             after TURBT on tumor lesion&#xD;
&#xD;
          -  Medical history of intravesical chemotherapy Subjects who received intravesical&#xD;
             chemotherapy prior to enrollment, but didn't receive BCG or other intravesical therapy&#xD;
             with immune drugs Subjected who are refractory to the recommended intravesical&#xD;
             chemotherapy drugs pirarubicin, epirubicin, doxorubicin, hydroxy camptothecin,&#xD;
             mitomycin, or gemcitabine (according to &quot;Guideline of Diagnosis and Treatment of&#xD;
             Urological Diseases in China&quot;, 2014 version)&#xD;
&#xD;
          -  Re-TURBT:&#xD;
&#xD;
        For subjects undergoing secondary TURBT, EORTC risk score must be ≥ 5, which can be&#xD;
        assessed based on the results of any TURBTs. The other results will be based on first TURBT&#xD;
        For subjects undergoing secondary TURBT, the enrollment time will start from the second&#xD;
        TURBT It is recommended to conduct the secondary TURBT under following situations:&#xD;
        incomplete first TURBT; no muscle tissue found in the first TURBT specimen, except Ta G1&#xD;
        (low grade) tumor and CIS only; T1 tumor; G3 (high grade) tumor (except CIS) The secondary&#xD;
        TURBT is recommended 2-6 weeks, but better at 4 weeks, after the first TURBT&#xD;
&#xD;
          -  Willing to provide biopsy specimen for assessment&#xD;
&#xD;
          -  ECOG PS ≤ 1, and did not deteriorate in 7 days&#xD;
&#xD;
          -  Patients must have normal organ and marrow function within 42 days of study entry&#xD;
             (according to normal range in clinical site) Absolute neutrophil count &gt;1.0×109/L&#xD;
             Platelets &gt; 100 ×109/L Hemoglobin &gt; 9.0 g/dl Alkaline phosphatase &lt; 2.5 ULN (&lt;10 X ULN&#xD;
             in presence of bone metastasis) GFR (Cockcroft-Gault formula calculated) ≥ 50 ml/min&#xD;
             INR &lt;1.5, except for subjects receiving warfarin therapy&#xD;
&#xD;
          -  Eligibility of patients receiving any medications or substances known to affect or&#xD;
             with the potential to affect the activity or pharmacokinetics of APL-1202 will be&#xD;
             determined following review of their case by the Principal Investigator&#xD;
&#xD;
          -  Female should be either surgically sterilized or menopause or agree to use effective&#xD;
             contraceptive measures during treatment&#xD;
&#xD;
          -  Male subjects must be surgically sterilized or agreed to use effective contraceptive&#xD;
             measures. Subjects must continue to take contraceptive measures within 3 months of the&#xD;
             end of the study treatment. The definition of effective contraceptive measures will be&#xD;
             based on the Principal Investigator or appointed delegate;&#xD;
&#xD;
          -  Expected life expectancy is more than 30 months&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  TBIL, ALT or AST &gt;1.5 x normal range (according to normal range in clinical sites)&#xD;
&#xD;
          -  Urothelial cell carcinoma in upper urethra or ureter&#xD;
&#xD;
          -  Received intravesical therapy in last TURBT/cystoscopy prior to enrollment period, but&#xD;
             not including immediate intravesical therapy once (the subjects who received the&#xD;
             immediate intravesical therapy need to be recorded in e-CRF)&#xD;
&#xD;
          -  Received surgery (not includes TURBT/cystoscopy), radiation therapy, or systemic&#xD;
             therapy within 6 weeks before enrollment&#xD;
&#xD;
          -  Malignancies within 2 years with exception of currently treated basal cell, squamous&#xD;
             cell carcinoma of the skin, or carcinoma &quot;in-situ' of the cervix&#xD;
&#xD;
          -  NCI CTCAE grade 3 hemorrhage within 6 weeks of starting study treatment&#xD;
&#xD;
          -  Any of the following within 6 months prior to study drug administration: myocardial&#xD;
             infarction, severe/unstable angina, coronary/peripheral artery bypass graft,&#xD;
             symptomatic congestive heart failure, cerebrovascular accident or transient ischemic&#xD;
             attack, or pulmonary embolism&#xD;
&#xD;
          -  Hypertension that cannot be controlled by medications&#xD;
&#xD;
          -  systolic blood pressure≥140 mmHg and/or diastolic blood pressure≥90mmHg&#xD;
&#xD;
          -  Uncontrolled active infections such as acute pneumonia, active hepatitis B, etc.&#xD;
&#xD;
          -  Dysphagia or known drug absorption disorders&#xD;
&#xD;
          -  Anuria&#xD;
&#xD;
          -  One week prior to enrollment, having hematuria&#xD;
&#xD;
          -  Active duodenal ulcers, ulcerative colitis and other gastrointestinal diseases or&#xD;
             other conditions that the investigator may determine to cause gastrointestinal&#xD;
             bleeding or perforation&#xD;
&#xD;
          -  Subjects that may increase the risk associated with study participation or study drug&#xD;
             administration, judged by investigator, or other severe acute or chronic medical&#xD;
             condition or optic nerve disorders may interfere with the interpretation and judgment&#xD;
             of study results&#xD;
&#xD;
          -  Pregnancy or breastfeeding. Female patients with reproductive potential have a&#xD;
             positive pregnancy test prior to enrollment&#xD;
&#xD;
          -  Psychological or mental abnormality, subjects are estimated to have insufficient&#xD;
             adherence to this clinical study&#xD;
&#xD;
          -  Four weeks prior to enrollment, participate in other clinical trials&#xD;
&#xD;
          -  Patients who had previously received anthracycline for systemic chemotherapy&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Dingwei Ye, MD,PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Fudan University</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Hanzhong Li, MD,PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Peking Union Medical College Hospital</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Fudan University Shanghai Cancer Center</name>
      <address>
        <city>Shanghai</city>
        <state>Shanghai</state>
        <country>China</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
  <verification_date>February 2022</verification_date>
  <study_first_submitted>July 23, 2020</study_first_submitted>
  <study_first_submitted_qc>July 26, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 29, 2020</study_first_posted>
  <last_update_submitted>February 21, 2022</last_update_submitted>
  <last_update_submitted_qc>February 21, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">February 22, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Urinary Bladder Neoplasms</mesh_term>
    <mesh_term>Non-Muscle Invasive Bladder Neoplasms</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Epirubicin</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04490993
org study id: YHCT-NIT-R1
nct id: NCT04490993
lead sponsor: 
has dmc: Yes
is fda regulated drug: Yes
is fda regulated device: No
To evaluate the clinical efficacy (median event-free survival) of APL-1202 in combination
      with Epirubicin hydrochloride versus Epirubicin hydrochloride alone in intermediate and
      high-risk chemo-refractory non-muscle invasive bladder cancer (NMIBC) patients
A multi-center, randomized, double-blind, placebo controlled Phase Ⅲ trial; including 3
      stages: screening period, treatment period, and follow-up period.

        -  Screening period: 6 weeks prior to treatment

        -  Treatment period:

        -  Induction period: APL-1202 is administered for 12 consecutive weeks

        -  Maintenance period: after 12-week drug free period, APL-1202 is administered for
           another12 consecutive weeks as maintenance treatment

        -  Follow up period: APL-1202 is administered at every 3-month interval if no events
           occurred in the treatment period and until the occurrence of events or the end of the
           entire clinical trial Intravesical Epirubicin hydrochloride will be administered once
           weekly for consecutive 6-8 weeks in the induction period, followed by once monthly in
           the maintenance period until end of 12 months
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
measure: Event-free survival
time frame: Up to 30 months
description: "Event"is defined as: pathologically confirmed recurrence, progression, or death resulting from bladder cancer
measure: Recurrent-free rate
time frame: 24 months
description: Recurrent-free rate
measure: Progression-free rate
time frame: 24 months
description: Progression-free rate
measure: Clinical benefit rate at 12,18, 24 months after enrollment (clinical benefits are defined as the pathological improvement of the recurrence, no high-risk recurrence, progression-free recurrence, no radical therapy and no death)
time frame: 24 months
description: Clinical benefit rate at 12,18, 24 months after enrollment (clinical benefits are defined as the pathological improvement of the recurrence, no high-risk recurrence, progression-free recurrence, no radical therapy and no death)
measure: Recurrence-free survival
time frame: Up to 30 months
description: Recurrence-free survival
measure: Progression-free survival
time frame: Up to 30 months
description: Progression-free survival
measure: Total survival
time frame: Up to 30 months
description: Total survival
arm group label: APL-1202 treatment
arm group type: Experimental
arm group label: Placebo
arm group type: Placebo Comparator
intervention type: Drug
intervention name: APL-1202 in combination with Epirubicin
description: Induction period: APL-1202 is administered for 12 consecutive weeks
Maintenance period: after 12-week drug free period, APL-1202 is administered for another12 consecutive weeks as maintenance treatment
Follow up period: APL-1202 is administered at every 3-month interval if no events occurred in the treatment period and until the occurrence of events or the end of the entire clinical trial Intravesical Epirubicin hydrochloride will be administered once weekly for consecutive 6-8 weeks in the induction period, followed by once monthly in the maintenance period until end of 12 months
arm group label: APL-1202 treatment
intervention type: Drug
intervention name: Placebo in combination with Epirubicin
description: Induction period: placebo is administered for 12 consecutive weeks
Maintenance period: after 12-week drug free period, placebo is administered for another12 consecutive weeks as maintenance treatment
Follow up period: APL-1202 is administered at every 3-month interval if no events occurred in the treatment period and until the occurrence of events or the end of the entire clinical trial Intravesical Epirubicin hydrochloride will be administered once weekly for consecutive 6-8 weeks in the induction period, followed by once monthly in the maintenance period until end of 12 months
arm group label: Placebo
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Dingwei Ye, MD,PhD
role: Principal Investigator
affiliation: Fudan University
last name: Hanzhong Li, MD,PhD
role: Principal Investigator
affiliation: Peking Union Medical College Hospital
facility: 
country: China
responsible party type: Sponsor
mesh term: Urinary Bladder Neoplasms
mesh term: Non-Muscle Invasive Bladder Neoplasms
mesh term: Epirubicin
sharing ipd: No