<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04488692</url>
  </required_header>
  <id_info>
    <org_study_id>CS19166</org_study_id>
    <nct_id>NCT04488692</nct_id>
  </id_info>
  <brief_title>Early Functional Training in Acute Stroke Inpatient Ward</brief_title>
  <official_title>The Effect of Two Models of an Early Intervention Program on Functional Recovery at Three Months to Acute Stroke Patients: A Randomized Controlled Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Chung Shan Medical University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Chung Shan Medical University</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      To investigate the difference between two models of an early intervention program (focused on&#xD;
      mobility function) in the functional recovery 3 months post stroke in a group of patients&#xD;
      with acute ischemic stroke while in acute inpatient ward hospitalization.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Patients with acute stroke admit into an acute inpatient ward who meet study criteria and&#xD;
      provide institutional-reviewed consent form will be randomly assigned into either model 1 or&#xD;
      model 2 of an early functional training program. Participants in model 1 group will receive 2&#xD;
      sessions of functional training per day whereas those in model 2 group will receive 1 session&#xD;
      of functional training and 1 session of friendly visit and education per day. The following&#xD;
      outcomes will be measured at admission, at discharge and at 3 months post stroke: Barthel&#xD;
      index (BI), Postural Assessment Scale for Stroke (PASS), Mobility Scale for Acute Stroke&#xD;
      (MASA), and usual gait speed (UGS). The rater is blinded to participants' group membership.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">September 1, 2020</start_date>
  <completion_date type="Actual">March 4, 2022</completion_date>
  <primary_completion_date type="Actual">March 4, 2022</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Postural Assessment Scale for Stroke Patient (PASS)</measure>
    <time_frame>Baseline</time_frame>
    <description>The total score range is 0 to 36 points. Higher score indicate better performance.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Postural Assessment Scale for Stroke Patient (PASS)</measure>
    <time_frame>up to 2 weeks</time_frame>
    <description>The total score range is 0 to 36 points. Higher score indicate better performance.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Postural Assessment Scale for Stroke Patient (PASS)</measure>
    <time_frame>at 3 months post stroke</time_frame>
    <description>The total score range is 0 to 36 points. Higher score indicate better performance.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Barthel index (BI)</measure>
    <time_frame>Baseline</time_frame>
    <description>The total score range is 0 to 100 points. Higher score indicate better performance.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Barthel index (BI)</measure>
    <time_frame>up to 2 weeks</time_frame>
    <description>The total score range is 0 to 100 points. Higher score indicate better performance.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Barthel index (BI)</measure>
    <time_frame>at 3 months post stroke</time_frame>
    <description>The total score range is 0 to 100 points. Higher score indicate better performance.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Usual gait speed</measure>
    <time_frame>Baseline</time_frame>
    <description>meters per second. Higher score indicate better performance.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Usual gait speed</measure>
    <time_frame>up to 2 weeks</time_frame>
    <description>meters per second. Higher score indicate better performance.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Usual gait speed</measure>
    <time_frame>at 3 months post stroke</time_frame>
    <description>meters per second. Higher score indicate better performance.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Mobility Scale for Acute Stroke (MSAS)</measure>
    <time_frame>Baseline</time_frame>
    <description>The total score range is 6 to 36 points. Higher score indicate better performance.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Mobility Scale for Acute Stroke (MSAS)</measure>
    <time_frame>up to 2 weeks</time_frame>
    <description>The total score range is 6 to 36 points. Higher score indicate better performance.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Mobility Scale for Acute Stroke (MSAS)</measure>
    <time_frame>at 3 months post stroke</time_frame>
    <description>The total score range is 6 to 36 points. Higher score indicate better performance.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">142</enrollment>
  <condition>Acute Stroke</condition>
  <arm_group>
    <arm_group_label>Model 1</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Participants will receive 2 sessions of functional training per day, 15-min per session.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Model 2</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Participants will receive 1 session of functional training and 1 session of sham intervention (therapist visiting and education) per day, 15-min per session.</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Early intervention (Mobility functional training)</intervention_name>
    <description>functional training focused on mobility (bed mobility, sitting balance, standing balance, and ambulation)</description>
    <arm_group_label>Model 1</arm_group_label>
    <arm_group_label>Model 2</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Sham intervention</intervention_name>
    <description>friendly visit and education</description>
    <arm_group_label>Model 2</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  patient with acute ischemic stroke / ICH&#xD;
&#xD;
          -  referred for early rehabilitation,&#xD;
&#xD;
          -  aged 20 years or more,&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  able to walk independently and safely at admission,&#xD;
&#xD;
          -  unable to understand three simple comments,&#xD;
&#xD;
          -  unable to recovery even with appropriate medical management,&#xD;
&#xD;
          -  serious condition require ICU care,&#xD;
&#xD;
          -  terminal illness for hospice care,&#xD;
&#xD;
          -  waiting to transfer to long term care facilities&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>20 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Ching-Yi Wang, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Chung Shan Medical University</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Chung Shan Medical University Hospital</name>
      <address>
        <city>Taichung</city>
        <zip>402</zip>
        <country>Taiwan</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Taiwan</country>
  </location_countries>
  <reference>
    <citation>Adams HP Jr, Brott TG, Crowell RM, Furlan AJ, Gomez CR, Grotta J, Helgason CM, Marler JR, Woolson RF, Zivin JA, et al. Guidelines for the management of patients with acute ischemic stroke. A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Circulation. 1994 Sep;90(3):1588-601. doi: 10.1161/01.cir.90.3.1588. No abstract available.</citation>
    <PMID>8087974</PMID>
  </reference>
  <reference>
    <citation>Bernhardt J, Churilov L, Ellery F, Collier J, Chamberlain J, Langhorne P, Lindley RI, Moodie M, Dewey H, Thrift AG, Donnan G; AVERT Collaboration Group. Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT). Neurology. 2016 Jun 7;86(23):2138-45. doi: 10.1212/WNL.0000000000002459. Epub 2016 Feb 17. Erratum In: Neurology. 2017 Jul 4;89(1):107.</citation>
    <PMID>26888985</PMID>
  </reference>
  <reference>
    <citation>Bernhardt J, Dewey H, Thrift A, Collier J, Donnan G. A very early rehabilitation trial for stroke (AVERT): phase II safety and feasibility. Stroke. 2008 Feb;39(2):390-6. doi: 10.1161/STROKEAHA.107.492363. Epub 2008 Jan 3.</citation>
    <PMID>18174489</PMID>
  </reference>
  <reference>
    <citation>Diserens K, Moreira T, Hirt L, Faouzi M, Grujic J, Bieler G, Vuadens P, Michel P. Early mobilization out of bed after ischaemic stroke reduces severe complications but not cerebral blood flow: a randomized controlled pilot trial. Clin Rehabil. 2012 May;26(5):451-9. doi: 10.1177/0269215511425541. Epub 2011 Dec 2.</citation>
    <PMID>22144725</PMID>
  </reference>
  <reference>
    <citation>Indredavik B, Bakke F, Solberg R, Rokseth R, Haaheim LL, Holme I. Benefit of a stroke unit: a randomized controlled trial. Stroke. 1991 Aug;22(8):1026-31. doi: 10.1161/01.str.22.8.1026.</citation>
    <PMID>1866749</PMID>
  </reference>
  <reference>
    <citation>Krakauer JW, Carmichael ST, Corbett D, Wittenberg GF. Getting neurorehabilitation right: what can be learned from animal models? Neurorehabil Neural Repair. 2012 Oct;26(8):923-31. doi: 10.1177/1545968312440745. Epub 2012 Mar 30.</citation>
    <PMID>22466792</PMID>
  </reference>
  <reference>
    <citation>Kwakkel G, van Peppen R, Wagenaar RC, Wood Dauphinee S, Richards C, Ashburn A, Miller K, Lincoln N, Partridge C, Wellwood I, Langhorne P. Effects of augmented exercise therapy time after stroke: a meta-analysis. Stroke. 2004 Nov;35(11):2529-39. doi: 10.1161/01.STR.0000143153.76460.7d. Epub 2004 Oct 7.</citation>
    <PMID>15472114</PMID>
  </reference>
  <reference>
    <citation>Langhorne P, Collier JM, Bate PJ, Thuy MN, Bernhardt J. Very early versus delayed mobilisation after stroke. Cochrane Database Syst Rev. 2018 Oct 16;10(10):CD006187. doi: 10.1002/14651858.CD006187.pub3.</citation>
    <PMID>30321906</PMID>
  </reference>
  <reference>
    <citation>Langhorne P, Wu O, Rodgers H, Ashburn A, Bernhardt J. A Very Early Rehabilitation Trial after stroke (AVERT): a Phase III, multicentre, randomised controlled trial. Health Technol Assess. 2017 Sep;21(54):1-120. doi: 10.3310/hta21540.</citation>
    <PMID>28967376</PMID>
  </reference>
  <reference>
    <citation>Langhorne P, Stott D, Knight A, Bernhardt J, Barer D, Watkins C. Very early rehabilitation or intensive telemetry after stroke: a pilot randomised trial. Cerebrovasc Dis. 2010;29(4):352-60. doi: 10.1159/000278931. Epub 2010 Jan 30.</citation>
    <PMID>20130401</PMID>
  </reference>
  <reference>
    <citation>Lee KB, Lim SH, Kim KH, Kim KJ, Kim YR, Chang WN, Yeom JW, Kim YD, Hwang BY. Six-month functional recovery of stroke patients: a multi-time-point study. Int J Rehabil Res. 2015 Jun;38(2):173-80. doi: 10.1097/MRR.0000000000000108.</citation>
    <PMID>25603539</PMID>
  </reference>
  <reference>
    <citation>Stinear CM, Byblow WD, Ackerley SJ, Smith MC, Borges VM, Barber PA. Proportional Motor Recovery After Stroke: Implications for Trial Design. Stroke. 2017 Mar;48(3):795-798. doi: 10.1161/STROKEAHA.116.016020. Epub 2017 Jan 31.</citation>
    <PMID>28143920</PMID>
  </reference>
  <reference>
    <citation>Sundseth A, Thommessen B, Ronning OM. Early mobilization after acute stroke. J Stroke Cerebrovasc Dis. 2014 Mar;23(3):496-9. doi: 10.1016/j.jstrokecerebrovasdis.2013.04.012. Epub 2013 May 13.</citation>
    <PMID>23680682</PMID>
  </reference>
  <reference>
    <citation>Verheyden G, Nieuwboer A, De Wit L, Thijs V, Dobbelaere J, Devos H, Severijns D, Vanbeveren S, De Weerdt W. Time course of trunk, arm, leg, and functional recovery after ischemic stroke. Neurorehabil Neural Repair. 2008 Mar-Apr;22(2):173-9. doi: 10.1177/1545968307305456. Epub 2007 Sep 17.</citation>
    <PMID>17876069</PMID>
  </reference>
  <reference>
    <citation>Wade DT, Wood VA, Hewer RL. Use of hospital resources by acute stroke patients. J R Coll Physicians Lond. 1985 Jan;19(1):48-52. No abstract available.</citation>
    <PMID>3973842</PMID>
  </reference>
  <reference>
    <citation>Xu T, Yu X, Ou S, Liu X, Yuan J, Chen Y. Efficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis. Sci Rep. 2017 Jul 26;7(1):6550. doi: 10.1038/s41598-017-06871-z.</citation>
    <PMID>28747763</PMID>
  </reference>
  <verification_date>October 2022</verification_date>
  <study_first_submitted>July 21, 2020</study_first_submitted>
  <study_first_submitted_qc>July 23, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 28, 2020</study_first_posted>
  <last_update_submitted>October 22, 2022</last_update_submitted>
  <last_update_submitted_qc>October 22, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">October 25, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Chung Shan Medical University</investigator_affiliation>
    <investigator_full_name>Ching-Yi Wang</investigator_full_name>
    <investigator_title>Professor</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Stroke</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04488692
org study id: CS19166
nct id: NCT04488692
lead sponsor: 
is fda regulated drug: No
is fda regulated device: No
To investigate the difference between two models of an early intervention program (focused on
      mobility function) in the functional recovery 3 months post stroke in a group of patients
      with acute ischemic stroke while in acute inpatient ward hospitalization.
Patients with acute stroke admit into an acute inpatient ward who meet study criteria and
      provide institutional-reviewed consent form will be randomly assigned into either model 1 or
      model 2 of an early functional training program. Participants in model 1 group will receive 2
      sessions of functional training per day whereas those in model 2 group will receive 1 session
      of functional training and 1 session of friendly visit and education per day. The following
      outcomes will be measured at admission, at discharge and at 3 months post stroke: Barthel
      index (BI), Postural Assessment Scale for Stroke (PASS), Mobility Scale for Acute Stroke
      (MASA), and usual gait speed (UGS). The rater is blinded to participants' group membership.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Double (Participant, Outcomes Assessor)
measure: Postural Assessment Scale for Stroke Patient (PASS)
time frame: Baseline
description: The total score range is 0 to 36 points. Higher score indicate better performance.
measure: Postural Assessment Scale for Stroke Patient (PASS)
time frame: up to 2 weeks
description: The total score range is 0 to 36 points. Higher score indicate better performance.
measure: Postural Assessment Scale for Stroke Patient (PASS)
time frame: at 3 months post stroke
description: The total score range is 0 to 36 points. Higher score indicate better performance.
measure: Barthel index (BI)
time frame: Baseline
description: The total score range is 0 to 100 points. Higher score indicate better performance.
measure: Barthel index (BI)
time frame: up to 2 weeks
description: The total score range is 0 to 100 points. Higher score indicate better performance.
measure: Barthel index (BI)
time frame: at 3 months post stroke
description: The total score range is 0 to 100 points. Higher score indicate better performance.
measure: Usual gait speed
time frame: Baseline
description: meters per second. Higher score indicate better performance.
measure: Usual gait speed
time frame: up to 2 weeks
description: meters per second. Higher score indicate better performance.
measure: Usual gait speed
time frame: at 3 months post stroke
description: meters per second. Higher score indicate better performance.
measure: Mobility Scale for Acute Stroke (MSAS)
time frame: Baseline
description: The total score range is 6 to 36 points. Higher score indicate better performance.
measure: Mobility Scale for Acute Stroke (MSAS)
time frame: up to 2 weeks
description: The total score range is 6 to 36 points. Higher score indicate better performance.
measure: Mobility Scale for Acute Stroke (MSAS)
time frame: at 3 months post stroke
description: The total score range is 6 to 36 points. Higher score indicate better performance.
arm group label: Model 1
arm group type: Experimental
description: Participants will receive 2 sessions of functional training per day, 15-min per session.
arm group label: Model 2
arm group type: Active Comparator
description: Participants will receive 1 session of functional training and 1 session of sham intervention (therapist visiting and education) per day, 15-min per session.
intervention type: Other
intervention name: Early intervention (Mobility functional training)
description: functional training focused on mobility (bed mobility, sitting balance, standing balance, and ambulation)
arm group label: Model 1
arm group label: Model 2
intervention type: Other
intervention name: Sham intervention
description: friendly visit and education
arm group label: Model 2
criteria: 
gender: All
minimum age: 20 Years
maximum age: N/A
healthy volunteers: No
last name: Ching-Yi Wang, PhD
role: Principal Investigator
affiliation: Chung Shan Medical University
facility: 
country: Taiwan
citation: Adams HP Jr, Brott TG, Crowell RM, Furlan AJ, Gomez CR, Grotta J, Helgason CM, Marler JR, Woolson RF, Zivin JA, et al. Guidelines for the management of patients with acute ischemic stroke. A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Circulation. 1994 Sep;90(3):1588-601. doi: 10.1161/01.cir.90.3.1588. No abstract available.
PMID: 8087974
citation: Bernhardt J, Churilov L, Ellery F, Collier J, Chamberlain J, Langhorne P, Lindley RI, Moodie M, Dewey H, Thrift AG, Donnan G; AVERT Collaboration Group. Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT). Neurology. 2016 Jun 7;86(23):2138-45. doi: 10.1212/WNL.0000000000002459. Epub 2016 Feb 17. Erratum In: Neurology. 2017 Jul 4;89(1):107.
PMID: 26888985
citation: Bernhardt J, Dewey H, Thrift A, Collier J, Donnan G. A very early rehabilitation trial for stroke (AVERT): phase II safety and feasibility. Stroke. 2008 Feb;39(2):390-6. doi: 10.1161/STROKEAHA.107.492363. Epub 2008 Jan 3.
PMID: 18174489
citation: Diserens K, Moreira T, Hirt L, Faouzi M, Grujic J, Bieler G, Vuadens P, Michel P. Early mobilization out of bed after ischaemic stroke reduces severe complications but not cerebral blood flow: a randomized controlled pilot trial. Clin Rehabil. 2012 May;26(5):451-9. doi: 10.1177/0269215511425541. Epub 2011 Dec 2.
PMID: 22144725
citation: Indredavik B, Bakke F, Solberg R, Rokseth R, Haaheim LL, Holme I. Benefit of a stroke unit: a randomized controlled trial. Stroke. 1991 Aug;22(8):1026-31. doi: 10.1161/01.str.22.8.1026.
PMID: 1866749
citation: Krakauer JW, Carmichael ST, Corbett D, Wittenberg GF. Getting neurorehabilitation right: what can be learned from animal models? Neurorehabil Neural Repair. 2012 Oct;26(8):923-31. doi: 10.1177/1545968312440745. Epub 2012 Mar 30.
PMID: 22466792
citation: Kwakkel G, van Peppen R, Wagenaar RC, Wood Dauphinee S, Richards C, Ashburn A, Miller K, Lincoln N, Partridge C, Wellwood I, Langhorne P. Effects of augmented exercise therapy time after stroke: a meta-analysis. Stroke. 2004 Nov;35(11):2529-39. doi: 10.1161/01.STR.0000143153.76460.7d. Epub 2004 Oct 7.
PMID: 15472114
citation: Langhorne P, Collier JM, Bate PJ, Thuy MN, Bernhardt J. Very early versus delayed mobilisation after stroke. Cochrane Database Syst Rev. 2018 Oct 16;10(10):CD006187. doi: 10.1002/14651858.CD006187.pub3.
PMID: 30321906
citation: Langhorne P, Wu O, Rodgers H, Ashburn A, Bernhardt J. A Very Early Rehabilitation Trial after stroke (AVERT): a Phase III, multicentre, randomised controlled trial. Health Technol Assess. 2017 Sep;21(54):1-120. doi: 10.3310/hta21540.
PMID: 28967376
citation: Langhorne P, Stott D, Knight A, Bernhardt J, Barer D, Watkins C. Very early rehabilitation or intensive telemetry after stroke: a pilot randomised trial. Cerebrovasc Dis. 2010;29(4):352-60. doi: 10.1159/000278931. Epub 2010 Jan 30.
PMID: 20130401
citation: Lee KB, Lim SH, Kim KH, Kim KJ, Kim YR, Chang WN, Yeom JW, Kim YD, Hwang BY. Six-month functional recovery of stroke patients: a multi-time-point study. Int J Rehabil Res. 2015 Jun;38(2):173-80. doi: 10.1097/MRR.0000000000000108.
PMID: 25603539
citation: Stinear CM, Byblow WD, Ackerley SJ, Smith MC, Borges VM, Barber PA. Proportional Motor Recovery After Stroke: Implications for Trial Design. Stroke. 2017 Mar;48(3):795-798. doi: 10.1161/STROKEAHA.116.016020. Epub 2017 Jan 31.
PMID: 28143920
citation: Sundseth A, Thommessen B, Ronning OM. Early mobilization after acute stroke. J Stroke Cerebrovasc Dis. 2014 Mar;23(3):496-9. doi: 10.1016/j.jstrokecerebrovasdis.2013.04.012. Epub 2013 May 13.
PMID: 23680682
citation: Verheyden G, Nieuwboer A, De Wit L, Thijs V, Dobbelaere J, Devos H, Severijns D, Vanbeveren S, De Weerdt W. Time course of trunk, arm, leg, and functional recovery after ischemic stroke. Neurorehabil Neural Repair. 2008 Mar-Apr;22(2):173-9. doi: 10.1177/1545968307305456. Epub 2007 Sep 17.
PMID: 17876069
citation: Wade DT, Wood VA, Hewer RL. Use of hospital resources by acute stroke patients. J R Coll Physicians Lond. 1985 Jan;19(1):48-52. No abstract available.
PMID: 3973842
citation: Xu T, Yu X, Ou S, Liu X, Yuan J, Chen Y. Efficacy and Safety of Very Early Mobilization in Patients with Acute Stroke: A Systematic Review and Meta-analysis. Sci Rep. 2017 Jul 26;7(1):6550. doi: 10.1038/s41598-017-06871-z.
PMID: 28747763
responsible party type: Principal Investigator
investigator affiliation: Chung Shan Medical University
investigator full name: Ching-Yi Wang
investigator title: Professor
mesh term: Stroke
sharing ipd: No