<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04441515</url>
  </required_header>
  <id_info>
    <org_study_id>MASTER1</org_study_id>
    <nct_id>NCT04441515</nct_id>
  </id_info>
  <brief_title>Music After Stroke To Enhance Rehabilitation</brief_title>
  <acronym>MASTER</acronym>
  <official_title>Music After Stroke To Enhance Rehabilitation</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Pace University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Emory University</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Pace University</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Music that is familiar and preferred by patients has been shown to heighten neuroplasticity&#xD;
      and can mitigate these disabilities. Therefore, this study seeks to explore the effect of&#xD;
      providing patient preferred music to patients in the very early post stroke period (within 24&#xD;
      hours of a left cerebral artery stroke [LMCA]event) as a complementary modality to usual&#xD;
      stroke care.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Aim I. The primary aim of MASTER is to identify whether a potential relationship exists&#xD;
      between an intervention of participant preferred music, when initiated within the first 24&#xD;
      hours following a left middle cerebral artery stroke, and a reduction in the following&#xD;
      disabilities: Expressive aphasia, right hand functional deficit and post stroke depression.&#xD;
      This aim will serve to address the first research hypothesis and address the relationship&#xD;
      between These disabilities are well known sequalae among patients diagnosed with the most&#xD;
      common form of stroke, a LMCA stroke. Participant preferred music within the first 24 hours&#xD;
      following a LMCA stroke and a reduction in: Expressive aphasia, right hand functional deficit&#xD;
      and post stroke depression, as these disabilities are well known sequalae among LMCA stroke&#xD;
      patients.&#xD;
&#xD;
      Aim II. The second aim of MASTER is to identify if a relationship exists between an&#xD;
      intervention of audible books, when initiated within the first 24 hours following a LMCA&#xD;
      stroke, and a reduction in the following disabilities: Expressive aphasia, right hand&#xD;
      functional deficit and post stroke depression.&#xD;
&#xD;
      Sufficient evidence exists to suggest that although listening to books stimulates cognitive&#xD;
      function, the effect of melody and participant engagement in music is far superior to&#xD;
      listening to words alone as the inherent rhythmicity of patient-favored music has been shown&#xD;
      to strengthen synchronous neuronal connectivity, by modulating dopamine and inducing fine&#xD;
      grained neuroanatomical changes in a recovering brain.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Not yet recruiting</overall_status>
  <start_date type="Anticipated">April 30, 2021</start_date>
  <completion_date type="Anticipated">December 30, 2023</completion_date>
  <primary_completion_date type="Anticipated">October 30, 2023</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>expressive aphasia measured by use of the WAB-R</measure>
    <time_frame>6 months</time_frame>
    <description>Change in expressive aphasia will be measured by use of the WAB-R. Western Aphasia Battery-Revised (WAB- R).This instrument is intended to provide a standardized measure of aphasia type and severity. Implementation of the instrument takes 15 approximately minutes to complete. THE WAB-R identifies and classifies 8 aphasia types: Global, Broca's, Isolation, Transcortical Motor, Wernicke's, transcortical Sensory, Conduction and Anomic. The WAB-R assesses linguistic skills more frequently affected by aphasia. Participants will be assessed at enrollment, discharge from hospital and again at 1,3,6 months post stroke.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>motor activity right hand as measured using the Motor Activity log</measure>
    <time_frame>6 months</time_frame>
    <description>Change in right hand motor activity and function will be assessed using the Motor Activity Log. The Motor Activity Log (MAL) is a semi-structured interview for hemiparetic stroke patients to assess the use of their paretic arm and hand Target tasks include object manipulation (e.g. pen, fork, comb, and cup) as well as the use of the arm during gross motor activities (e.g. transferring to a car, steadying oneself during standing, pulling a chair into a table while sitting). Participants will be assessed at enrollment, discharge from hospital and again at 1,3,6 months post stroke.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Depressive symptoms as measured using the PHQ-9</measure>
    <time_frame>6 months</time_frame>
    <description>A change in depressive symptoms will be assessed using the PHQ-9. The PHQ-9 will be used for screening for depression, as it has been identified as the preferred (gold standard) screening tool for depression among post stroke patients in hospitals. The PHQ-9 takes less than 5 minutes to administer, and has been shown to have superior sensitivity and specificity.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Quality of life as measured using the 20 item short form survey (SF-20)</measure>
    <time_frame>6 months</time_frame>
    <description>Change quality of life is assessed in this study, a 20-item short form survey (SF-20) will be used to assess quality of life. Participants will be assessed at enrollment, discharge from hospital and again at 1,3,6 months post stroke.</description>
  </primary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Anticipated">12</enrollment>
  <condition>Stroke, Acute</condition>
  <condition>Expressive Aphasia</condition>
  <condition>Movement, Abnormal</condition>
  <condition>Depressive Disorder</condition>
  <arm_group>
    <arm_group_label>Music</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>music supplied by ipod</description>
  </arm_group>
  <arm_group>
    <arm_group_label>oral books</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Listening to books on ipod</description>
  </arm_group>
  <arm_group>
    <arm_group_label>usual care</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Usual care</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Ipod with music</intervention_name>
    <description>music of patient's preference provided 2 hours daily</description>
    <arm_group_label>Music</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>ipod with books to listen</intervention_name>
    <description>2 hours of daily listening to books</description>
    <arm_group_label>oral books</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>ipod only with usual care</intervention_name>
    <description>participants given device only</description>
    <arm_group_label>usual care</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Clinical diagnosis of LMCA stroke within prior 24 hours&#xD;
&#xD;
          -  Not identified as critically ill&#xD;
&#xD;
          -  Glascow Coma Scale &gt; 8 at time of consent&#xD;
&#xD;
          -  Resident of a home with a land line or cell phone&#xD;
&#xD;
          -  Able to speak in English or Spanish prior to stroke event&#xD;
&#xD;
          -  Presence of expressive aphasia at time of enrollment.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Stroke diagnosis other than LMCA territory stroke&#xD;
&#xD;
          -  Unable to provide consent by patient or legally accountable person acting on behalf of&#xD;
             the patient (healthcare proxy, healthcare power of attorney), Patient/ representative&#xD;
&#xD;
          -  Does not speak English or Spanish prior to stroke event&#xD;
&#xD;
          -  Have a diagnosis of end stage cancer, or other medical conditions that dramatically&#xD;
             increase a risk of mortality within one year&#xD;
&#xD;
          -  Any pre-existing communication disorder (including dementia)&#xD;
&#xD;
          -  Patients that are deemed critically ill will not be included&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Millie Hepburn, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Pace University</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Millie Hepburn, PhD</last_name>
    <phone>9147733367</phone>
    <email>mhepburnsmith@pace.edu</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Lori Sutherly, MS</last_name>
    <phone>4192960978</phone>
    <email>lori.j.sutherly@emory.edu</email>
  </overall_contact_backup>
  <reference>
    <citation>Flanagan J. (1978). A research approach to improving our quality of life. American Psychologist, 33, 138-147.</citation>
  </reference>
  <reference>
    <citation>Kertesz, A. (2006). Western Aphasia Battery-Revised. San Antonio, TX: Pearson.</citation>
  </reference>
  <results_reference>
    <citation>Amengual JL, Rojo N, Veciana de Las Heras M, Marco-Pallares J, Grau-Sanchez J, Schneider S, Vaquero L, Juncadella M, Montero J, Mohammadi B, Rubio F, Rueda N, Duarte E, Grau C, Altenmuller E, Munte TF, Rodriguez-Fornells A. Sensorimotor plasticity after music-supported therapy in chronic stroke patients revealed by transcranial magnetic stimulation. PLoS One. 2013 Apr 17;8(4):e61883. doi: 10.1371/journal.pone.0061883. Print 2013.</citation>
    <PMID>23613966</PMID>
  </results_reference>
  <results_reference>
    <citation>Carver DJ, Chapman CA, Thomas VS, Stadnyk KJ, Rockwood K. Validity and reliability of the Medical Outcomes Study Short Form-20 questionnaire as a measure of quality of life in elderly people living at home. Age Ageing. 1999 Mar;28(2):169-74. doi: 10.1093/ageing/28.2.169.</citation>
    <PMID>10350414</PMID>
  </results_reference>
  <results_reference>
    <citation>Edmonds LA, Donovan NJ. Item-level psychometrics and predictors of performance for Spanish/English bilingual speakers on an object and action naming battery. J Speech Lang Hear Res. 2012 Apr;55(2):359-81. doi: 10.1044/1092-4388(2011/10-0307). Epub 2012 Jan 3.</citation>
    <PMID>22215032</PMID>
  </results_reference>
  <results_reference>
    <citation>Fox K, Stryker M. Integrating Hebbian and homeostatic plasticity: introduction. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 5;372(1715):20160413. doi: 10.1098/rstb.2016.0413.</citation>
    <PMID>28093560</PMID>
  </results_reference>
  <results_reference>
    <citation>Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x.</citation>
    <PMID>11556941</PMID>
  </results_reference>
  <results_reference>
    <citation>Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL; American Heart Association Stroke Council. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2018 Mar;49(3):e46-e110. doi: 10.1161/STR.0000000000000158. Epub 2018 Jan 24. Erratum In: Stroke. 2018 Mar;49(3):e138. Stroke. 2018 Apr 18;:</citation>
    <PMID>29367334</PMID>
  </results_reference>
  <results_reference>
    <citation>Kim M, Tomaino CM. Protocol evaluation for effective music therapy for persons with nonfluent aphasia. Top Stroke Rehabil. 2008 Nov-Dec;15(6):555-69. doi: 10.1310/tsr1506-555.</citation>
    <PMID>19158063</PMID>
  </results_reference>
  <results_reference>
    <citation>Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999 Nov 10;282(18):1737-44. doi: 10.1001/jama.282.18.1737.</citation>
    <PMID>10568646</PMID>
  </results_reference>
  <results_reference>
    <citation>Scholz DS, Rohde S, Nikmaram N, Bruckner HP, Grossbach M, Rollnik JD, Altenmuller EO. Sonification of Arm Movements in Stroke Rehabilitation - A Novel Approach in Neurologic Music Therapy. Front Neurol. 2016 Jun 30;7:106. doi: 10.3389/fneur.2016.00106. eCollection 2016.</citation>
    <PMID>27445970</PMID>
  </results_reference>
  <results_reference>
    <citation>Uswatte G, Taub E, Morris D, Light K, Thompson PA. The Motor Activity Log-28: assessing daily use of the hemiparetic arm after stroke. Neurology. 2006 Oct 10;67(7):1189-94. doi: 10.1212/01.wnl.0000238164.90657.c2.</citation>
    <PMID>17030751</PMID>
  </results_reference>
  <results_reference>
    <citation>van der Lee JH, Beckerman H, Knol DL, de Vet HC, Bouter LM. Clinimetric properties of the motor activity log for the assessment of arm use in hemiparetic patients. Stroke. 2004 Jun;35(6):1410-4. doi: 10.1161/01.STR.0000126900.24964.7e. Epub 2004 Apr 15.</citation>
    <PMID>15087552</PMID>
  </results_reference>
  <verification_date>March 2021</verification_date>
  <study_first_submitted>June 10, 2020</study_first_submitted>
  <study_first_submitted_qc>June 18, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 22, 2020</study_first_posted>
  <last_update_submitted>March 10, 2021</last_update_submitted>
  <last_update_submitted_qc>March 10, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">March 11, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Stroke</mesh_term>
    <mesh_term>Aphasia</mesh_term>
    <mesh_term>Dyskinesias</mesh_term>
    <mesh_term>Aphasia, Broca</mesh_term>
    <mesh_term>Depressive Disorder</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04441515
org study id: MASTER1
nct id: NCT04441515
lead sponsor: 
collaborator: 
is fda regulated drug: No
is fda regulated device: No
Music that is familiar and preferred by patients has been shown to heighten neuroplasticity
      and can mitigate these disabilities. Therefore, this study seeks to explore the effect of
      providing patient preferred music to patients in the very early post stroke period (within 24
      hours of a left cerebral artery stroke [LMCA]event) as a complementary modality to usual
      stroke care.
Aim I. The primary aim of MASTER is to identify whether a potential relationship exists
      between an intervention of participant preferred music, when initiated within the first 24
      hours following a left middle cerebral artery stroke, and a reduction in the following
      disabilities: Expressive aphasia, right hand functional deficit and post stroke depression.
      This aim will serve to address the first research hypothesis and address the relationship
      between These disabilities are well known sequalae among patients diagnosed with the most
      common form of stroke, a LMCA stroke. Participant preferred music within the first 24 hours
      following a LMCA stroke and a reduction in: Expressive aphasia, right hand functional deficit
      and post stroke depression, as these disabilities are well known sequalae among LMCA stroke
      patients.

      Aim II. The second aim of MASTER is to identify if a relationship exists between an
      intervention of audible books, when initiated within the first 24 hours following a LMCA
      stroke, and a reduction in the following disabilities: Expressive aphasia, right hand
      functional deficit and post stroke depression.

      Sufficient evidence exists to suggest that although listening to books stimulates cognitive
      function, the effect of melody and participant engagement in music is far superior to
      listening to words alone as the inherent rhythmicity of patient-favored music has been shown
      to strengthen synchronous neuronal connectivity, by modulating dopamine and inducing fine
      grained neuroanatomical changes in a recovering brain.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: expressive aphasia measured by use of the WAB-R
time frame: 6 months
description: Change in expressive aphasia will be measured by use of the WAB-R. Western Aphasia Battery-Revised (WAB- R).This instrument is intended to provide a standardized measure of aphasia type and severity. Implementation of the instrument takes 15 approximately minutes to complete. THE WAB-R identifies and classifies 8 aphasia types: Global, Broca's, Isolation, Transcortical Motor, Wernicke's, transcortical Sensory, Conduction and Anomic. The WAB-R assesses linguistic skills more frequently affected by aphasia. Participants will be assessed at enrollment, discharge from hospital and again at 1,3,6 months post stroke.
measure: motor activity right hand as measured using the Motor Activity log
time frame: 6 months
description: Change in right hand motor activity and function will be assessed using the Motor Activity Log. The Motor Activity Log (MAL) is a semi-structured interview for hemiparetic stroke patients to assess the use of their paretic arm and hand Target tasks include object manipulation (e.g. pen, fork, comb, and cup) as well as the use of the arm during gross motor activities (e.g. transferring to a car, steadying oneself during standing, pulling a chair into a table while sitting). Participants will be assessed at enrollment, discharge from hospital and again at 1,3,6 months post stroke.
measure: Depressive symptoms as measured using the PHQ-9
time frame: 6 months
description: A change in depressive symptoms will be assessed using the PHQ-9. The PHQ-9 will be used for screening for depression, as it has been identified as the preferred (gold standard) screening tool for depression among post stroke patients in hospitals. The PHQ-9 takes less than 5 minutes to administer, and has been shown to have superior sensitivity and specificity.
measure: Quality of life as measured using the 20 item short form survey (SF-20)
time frame: 6 months
description: Change quality of life is assessed in this study, a 20-item short form survey (SF-20) will be used to assess quality of life. Participants will be assessed at enrollment, discharge from hospital and again at 1,3,6 months post stroke.
arm group label: Music
arm group type: Experimental
description: music supplied by ipod
arm group label: oral books
arm group type: Active Comparator
description: Listening to books on ipod
arm group label: usual care
arm group type: Placebo Comparator
description: Usual care
intervention type: Device
intervention name: Ipod with music
description: music of patient's preference provided 2 hours daily
arm group label: Music
intervention type: Device
intervention name: ipod with books to listen
description: 2 hours of daily listening to books
arm group label: oral books
intervention type: Device
intervention name: ipod only with usual care
description: participants given device only
arm group label: usual care
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Millie Hepburn, PhD
role: Principal Investigator
affiliation: Pace University
last name: Millie Hepburn, PhD
phone: 9147733367
email: mhepburnsmith@pace.edu
last name: Lori Sutherly, MS
phone: 4192960978
email: lori.j.sutherly@emory.edu
citation: Flanagan J. (1978). A research approach to improving our quality of life. American Psychologist, 33, 138-147.
citation: Kertesz, A. (2006). Western Aphasia Battery-Revised. San Antonio, TX: Pearson.
citation: Amengual JL, Rojo N, Veciana de Las Heras M, Marco-Pallares J, Grau-Sanchez J, Schneider S, Vaquero L, Juncadella M, Montero J, Mohammadi B, Rubio F, Rueda N, Duarte E, Grau C, Altenmuller E, Munte TF, Rodriguez-Fornells A. Sensorimotor plasticity after music-supported therapy in chronic stroke patients revealed by transcranial magnetic stimulation. PLoS One. 2013 Apr 17;8(4):e61883. doi: 10.1371/journal.pone.0061883. Print 2013.
PMID: 23613966
citation: Carver DJ, Chapman CA, Thomas VS, Stadnyk KJ, Rockwood K. Validity and reliability of the Medical Outcomes Study Short Form-20 questionnaire as a measure of quality of life in elderly people living at home. Age Ageing. 1999 Mar;28(2):169-74. doi: 10.1093/ageing/28.2.169.
PMID: 10350414
citation: Edmonds LA, Donovan NJ. Item-level psychometrics and predictors of performance for Spanish/English bilingual speakers on an object and action naming battery. J Speech Lang Hear Res. 2012 Apr;55(2):359-81. doi: 10.1044/1092-4388(2011/10-0307). Epub 2012 Jan 3.
PMID: 22215032
citation: Fox K, Stryker M. Integrating Hebbian and homeostatic plasticity: introduction. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 5;372(1715):20160413. doi: 10.1098/rstb.2016.0413.
PMID: 28093560
citation: Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x.
PMID: 11556941
citation: Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL; American Heart Association Stroke Council. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2018 Mar;49(3):e46-e110. doi: 10.1161/STR.0000000000000158. Epub 2018 Jan 24. Erratum In: Stroke. 2018 Mar;49(3):e138. Stroke. 2018 Apr 18;:
PMID: 29367334
citation: Kim M, Tomaino CM. Protocol evaluation for effective music therapy for persons with nonfluent aphasia. Top Stroke Rehabil. 2008 Nov-Dec;15(6):555-69. doi: 10.1310/tsr1506-555.
PMID: 19158063
citation: Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999 Nov 10;282(18):1737-44. doi: 10.1001/jama.282.18.1737.
PMID: 10568646
citation: Scholz DS, Rohde S, Nikmaram N, Bruckner HP, Grossbach M, Rollnik JD, Altenmuller EO. Sonification of Arm Movements in Stroke Rehabilitation - A Novel Approach in Neurologic Music Therapy. Front Neurol. 2016 Jun 30;7:106. doi: 10.3389/fneur.2016.00106. eCollection 2016.
PMID: 27445970
citation: Uswatte G, Taub E, Morris D, Light K, Thompson PA. The Motor Activity Log-28: assessing daily use of the hemiparetic arm after stroke. Neurology. 2006 Oct 10;67(7):1189-94. doi: 10.1212/01.wnl.0000238164.90657.c2.
PMID: 17030751
citation: van der Lee JH, Beckerman H, Knol DL, de Vet HC, Bouter LM. Clinimetric properties of the motor activity log for the assessment of arm use in hemiparetic patients. Stroke. 2004 Jun;35(6):1410-4. doi: 10.1161/01.STR.0000126900.24964.7e. Epub 2004 Apr 15.
PMID: 15087552
responsible party type: Sponsor
mesh term: Stroke
mesh term: Aphasia
mesh term: Dyskinesias
mesh term: Aphasia, Broca
mesh term: Depressive Disorder
sharing ipd: No