<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04435938</url>
  </required_header>
  <id_info>
    <org_study_id>8134</org_study_id>
    <nct_id>NCT04435938</nct_id>
  </id_info>
  <brief_title>A Study of SBRT for Squamous Cell Carcinoma of the Head and Neck</brief_title>
  <acronym>SHINE</acronym>
  <official_title>A Phase 2 Study of SBRT for Squamous Cell Carcinoma of the Head and Neck</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>McMaster University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Juravinski Cancer Centre Foundation</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>McMaster University</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      To evaluate the tumour response rate of squamous cell carcinoma of the head and neck&#xD;
      following stereotactic body radiotherapy (SBRT) of 45Gy in 5 fractions delivered once every&#xD;
      3-4 days, such that treatment is completed within 15 days.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Cancers of the head and neck region account for approximately 4% of all new cancer cases.&#xD;
      Primary skin cancers are the most common malignancy diagnosed in North America with the&#xD;
      majority of tumours arising in the cervico-facial region.Together, these tumours comprise a&#xD;
      high burden of illness and are often characterized by locally advanced, non-metastatic&#xD;
      disease.&#xD;
&#xD;
      Determining the optimal treatment for individual patients with advanced cervico-facial&#xD;
      cancers of the skin or primary head and neck squamous cell carcinoma (HNSCC) is clinically&#xD;
      challenging; standard treatments include combinations of surgery, radiation and chemotherapy,&#xD;
      all of which are associated with high rates of acute toxicity and complications. A&#xD;
      meta-analysis of randomized controlled trials did not demonstrate benefit with concurrent&#xD;
      chemotherapy in patients over the age of 70 or with performance status ≥ 2, and it is&#xD;
      recognized that the high burden of medical co-morbidities in HNSCC is associated with poorer&#xD;
      prognosis. Some patients without distant metastases may be deemed to have 'incurable' disease&#xD;
      due to very advanced tumours, recurrence, severe medical co-morbidities or frailty that&#xD;
      prohibit the use of standard surgery, general anaesthetic and/or radiotherapy over 6-7 weeks.&#xD;
&#xD;
      When conventional surgery and/or radiotherapy are not recommended by the multi-disciplinary&#xD;
      team then patients may be treated with shorter, hypo-fractionated radiotherapy with the goal&#xD;
      of symptom relief and local control but at the cost of a lower biological dose. Investigators&#xD;
      at the Juravinski Cancer Centre published retrospective results from the '0-7-21' regimen&#xD;
      using 24 Gy / 3 fractions which was well tolerated and provided temporary symptom relief in&#xD;
      82% of patients but reported 6 month progression free survival of 39% within the irradiated&#xD;
      field; a phase 2 study of previously untreated HNSCC patients deemed to have incurable&#xD;
      disease used up to 42 Gy/12 fractions and demonstrated similar rates of initial response and&#xD;
      symptom relief but a short progression free survival duration of 3.1 months. One study&#xD;
      reported an institutional experience of palliative radiotherapy in newly diagnosed head and&#xD;
      neck cancer patients who were deemed to have incurable disease and received a wide range of&#xD;
      dose/fractionation regimens. The median radiation dose was 50 Gy and between 57-82% of&#xD;
      patients were reported to have any radiological, clinical or symptomatic response to&#xD;
      treatment. In these three studies, the patients were older with median ages of 71, 73, and 77&#xD;
      years - and median survival was short 5.2, 5.7 and 6.2 months.&#xD;
&#xD;
      With respect to squamous cell carcinoma (SCC) of the skin, there is limited evidence to guide&#xD;
      treatment in patients with unresectable or medically inoperable disease, particularly in the&#xD;
      head and neck region. There is a need for prospective data on non-surgical treatment options&#xD;
      for frail older adults which improve efficacy while limiting the treatment burden.&#xD;
&#xD;
      SBRT can limit the number of treatments while delivering a higher, potentially curative dose.&#xD;
      An international consortium of 15 high volume cancer centres reported on a survey of&#xD;
      practices using SBRT for head and neck cancers. There was heterogeneity in the indications,&#xD;
      techniques and doses reported by various institutions. The most common indication was in the&#xD;
      setting of recurrent disease and reported doses were in the range of 35-50 Gy in 3-5&#xD;
      fractions. Several institutions reported 1-2 year local control rates of 65-90% with SBRT and&#xD;
      acceptable levels of toxicity. To our knowledge, there are no prospective clinical studies&#xD;
      evaluating tumour response, toxicity and quality of life in previously unirradiated patients.&#xD;
&#xD;
      The goal of the current study is to prospectively evaluate tumour response, toxicity and&#xD;
      patient quality of life in patients with HNSCC undergoing SBRT.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">September 10, 2020</start_date>
  <completion_date type="Anticipated">December 2022</completion_date>
  <primary_completion_date type="Anticipated">June 2022</primary_completion_date>
  <phase>Phase 2</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>N/A</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <intervention_model_description>Eligible and consenting patients will be treated with the dose prescribed in the study of 45Gy in 5 fractions, delivered once every 3-4 days, such that treatment is completed within 15 days (Exceptions: treatment duration of up to 18 days will be allowed to account for cancer centre closures and unforeseen patient issues). Using the Simon optimal two-stage design, 11 patients will be recruited in the first stage. If 6 or less patients have a response, the study will be stopped at the end of stage I, however, if 7 or more patients have a response the study will continue to stage II, in which an additional 27 patients (for a total of 38) will be recruited. At the end of stage II, if 26 or less patients have a response, then H0 will be accepted and the treatment regimen deemed not worthy of further study, however, if 27 or more patients have a response, the treatment regimen will be recommended for further study in phase III.</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Tumour response rate</measure>
    <time_frame>The best overall response across all time points during the study period - up to 24 months after completion of SBRT.</time_frame>
    <description>Tumour response rate defined as complete or partial response according to Tumour response rate will be defined by RECIST 1.1 criteria</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Number of participants with Acute and Late Toxicity</measure>
    <time_frame>Up to 24 months after completion of SBRT</time_frame>
    <description>Acute toxicity (during and up to 3 months from the end of treatment) and late toxicity (after 3 months) adverse effects secondary to SBRT treatment will be graded according to the Common Terminology Criteria for Adverse Events (CTCAE v5.0) scale.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Local Control</measure>
    <time_frame>Determination of local recurrence will be based on based on RECIST criteria 1.1 (see section 11.3 below) and assessed on MRI or CT scan imaging at 12 weeks and any additional imaging/clinical assessments performed during the study.</time_frame>
    <description>The absence of local progression of disease of the target lesions during the study period.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Quality of Life as measured by the FACT-HN questionnaire</measure>
    <time_frame>The FACT-HN Quesionnaire will be administered at Baseline, once during treatment, 6 weeks, 3, 6, 12 months post SBRT treatment. Higher scores represent better qualtiy of life.</time_frame>
    <description>Assessed using the FACT-HN questionnaire</description>
  </secondary_outcome>
  <number_of_arms>1</number_of_arms>
  <enrollment type="Anticipated">38</enrollment>
  <condition>Head and Neck Neoplasms</condition>
  <condition>Squamous Cell Carcinoma</condition>
  <condition>Squamous Skin Carcinoma</condition>
  <arm_group>
    <arm_group_label>Stereotactic Body Radiotherapy (SBRT)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>The dose prescribed in the study will be 45Gy in 5 fractions, delivered once every 3-4 days, such that treatment is completed within 15 days. (e.g. treatment given on Monday/Thursday/Mon/Thurs/Mon) (Exceptions: treatment duration of up to 18 days will be allowed to account for cancer centre closures and unforeseen patient issues.)</description>
  </arm_group>
  <intervention>
    <intervention_type>Radiation</intervention_type>
    <intervention_name>Stereotactic Body Radiotherapy (SBRT)</intervention_name>
    <description>45 Gy in 5 fractions delivered once every 3-4 days</description>
    <arm_group_label>Stereotactic Body Radiotherapy (SBRT)</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. Age &gt;= 60 years&#xD;
&#xD;
          2. Histologically confirmed diagnosis of squamous cell carcinoma of the head and neck&#xD;
             region including primary skin SCC; (malignant cells with suspicious/likely SCC will be&#xD;
             considered for study if repeat biopsy is not feasible)&#xD;
&#xD;
          3. Clinical stage ≥ T2, or any T-stage with N1-N3 disease, M0 or Mx&#xD;
&#xD;
          4. Measurable tumour present in the head and neck region on clinical examination and/or&#xD;
             imaging at time of study enrollment&#xD;
&#xD;
          5. All patients will be assessed by a multi-disciplinary, head and neck oncology team&#xD;
             with no systemic therapy being recommended at the time of enrollment&#xD;
&#xD;
          6. Primary surgery not recommended/performed due to any of the following:&#xD;
&#xD;
               -  Unresectable disease and/or borderline resectable&#xD;
&#xD;
               -  Medically inoperable / deemed high risk for post-operative morbidity/mortality by&#xD;
                  surgical team&#xD;
&#xD;
               -  Patient declined surgery&#xD;
&#xD;
          7. Deemed not to be a candidate for standard fractionation radiotherapy due to poor&#xD;
             performance status and/or medical co-morbidities and/or advanced stage disease&#xD;
&#xD;
          8. Eastern Co-operative Oncology Group (ECOG) Performance Status ≤ 3&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Life expectancy ≤ 3 months&#xD;
&#xD;
          2. Chemotherapy or other systemic cancer therapy within 3 months prior to HN SBRT&#xD;
&#xD;
          3. Basal cell carcinoma, Merkel cell, malignant melanoma, adenocarcinoma are excluded&#xD;
&#xD;
          4. HN surgery within 6 months prior to HN SBRT (excision under local anaesthesia is&#xD;
             acceptable)&#xD;
&#xD;
          5. Prior radiation treatment to the head and neck region (prior radiotherapy to the skin&#xD;
             for non-melanoma skin cancer and deemed to have no risk of overlap with the current&#xD;
             field are eligible)&#xD;
&#xD;
          6. Synchronous or recent cancer diagnosis not including the index cancer (other cancers&#xD;
             treated curatively with no evidence of disease for &gt;=3 years, or other non- melanoma&#xD;
             skin cancers treated with no evidence of disease for &gt;= 6 months are eligible)&#xD;
&#xD;
          7. Confirmed or known distant metastatic disease.&#xD;
&#xD;
          8. Serious non-malignant disease that precludes definitive radiation treatment (e.g.&#xD;
&#xD;
             severe cases of scleroderma, systemic lupus erythematosus, rheumatoid arthritis)&#xD;
&#xD;
          9. Unable to provide written, informed consent or complete QoL questionnaires and&#xD;
             assessments required on the study&#xD;
&#xD;
         10. Unable to lie flat for 60 minutes in order to have radiation planning and treatment&#xD;
&#xD;
         11. Unable to attend radiation planning and therapy, as well as follow-up care and&#xD;
             assessments&#xD;
&#xD;
         12. Unable to provide written, informed consent&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>60 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Justin Lee, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Juravinski Cancer Centre</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Shelley Chambers, MA</last_name>
    <phone>905-387-9711</phone>
    <phone_ext>64510</phone_ext>
    <email>chamberss@hhsc.ca</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Thivya Jeyachanthiran</last_name>
    <phone>905-387-9495</phone>
    <email>jeyachanth@hhsc.ca</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Juravinski Cancer Centre</name>
      <address>
        <city>Hamilton</city>
        <state>Ontario</state>
        <zip>L8V 5C2</zip>
        <country>Canada</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Shelley Chambers, MA</last_name>
      <phone>905-387-9711</phone>
      <phone_ext>64510</phone_ext>
      <email>chamberss@hhsc.ca</email>
    </contact>
    <contact_backup>
      <last_name>Thivya Jeyanchanthiran</last_name>
      <phone>905-387-9495</phone>
      <email>jeyanchanth@hhsc.ca</email>
    </contact_backup>
    <investigator>
      <last_name>Justin Lee, MD</last_name>
      <role>Principal Investigator</role>
    </investigator>
    <investigator>
      <last_name>Anand Swaminath, MD</last_name>
      <role>Sub-Investigator</role>
    </investigator>
    <investigator>
      <last_name>Kimmen Quan, MD</last_name>
      <role>Sub-Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>Canada</country>
  </location_countries>
  <link>
    <url>http://www.cancer.gov/</url>
    <description>Cancer Statistics. National Cancer Institute.</description>
  </link>
  <reference>
    <citation>Eskander A, Krzyzanowska MK, Fischer HD, Liu N, Austin PC, Irish JC, Enepekides DJ, Lee J, Gutierrez E, Lockhart E, Raphael M, Singh S. Emergency department visits and unplanned hospitalizations in the treatment period for head and neck cancer patients treated with curative intent: A population-based analysis. Oral Oncol. 2018 Aug;83:107-114. doi: 10.1016/j.oraloncology.2018.06.011. Epub 2018 Jun 19.</citation>
    <PMID>30098764</PMID>
  </reference>
  <reference>
    <citation>Pignon JP, le Maitre A, Maillard E, Bourhis J; MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol. 2009 Jul;92(1):4-14. doi: 10.1016/j.radonc.2009.04.014. Epub 2009 May 14.</citation>
    <PMID>19446902</PMID>
  </reference>
  <reference>
    <citation>Reid BC, Alberg AJ, Klassen AC, Samet JM, Rozier RG, Garcia I, Winn DM. Comorbidity and survival of elderly head and neck carcinoma patients. Cancer. 2001 Oct 15;92(8):2109-16. doi: 10.1002/1097-0142(20011015)92:83.0.co;2-m.</citation>
    <PMID>11596027</PMID>
  </reference>
  <reference>
    <citation>Datema FR, Ferrier MB, van der Schroeff MP, Baatenburg de Jong RJ. Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. Head Neck. 2010 Jun;32(6):728-36. doi: 10.1002/hed.21245.</citation>
    <PMID>19827120</PMID>
  </reference>
  <reference>
    <citation>Nguyen NT, Doerwald-Munoz L, Zhang H, Kim DH, Sagar S, Wright JR, Hodson DI. 0-7-21 hypofractionated palliative radiotherapy: an effective treatment for advanced head and neck cancers. Br J Radiol. 2015 May;88(1049):20140646. doi: 10.1259/bjr.20140646. Epub 2015 Feb 19.</citation>
    <PMID>25694259</PMID>
  </reference>
  <reference>
    <citation>Corry J, Peters LJ, Costa ID, Milner AD, Fawns H, Rischin D, Porceddu S. The 'QUAD SHOT'--a phase II study of palliative radiotherapy for incurable head and neck cancer. Radiother Oncol. 2005 Nov;77(2):137-42. doi: 10.1016/j.radonc.2005.10.008. Epub 2005 Nov 2.</citation>
    <PMID>16260054</PMID>
  </reference>
  <reference>
    <citation>Stevens CM, Huang SH, Fung S, Bayley AJ, Cho JB, Cummings BJ, Dawson LA, Hope AJ, Kim JJ, O'Sullivan B, Waldron JN, Ringash J. Retrospective study of palliative radiotherapy in newly diagnosed head and neck carcinoma. Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):958-63. doi: 10.1016/j.ijrobp.2010.06.055. Epub 2010 Oct 14.</citation>
    <PMID>20950952</PMID>
  </reference>
  <reference>
    <citation>Lansbury L, Bath-Hextall F, Perkins W, Stanton W, Leonardi-Bee J. Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies. BMJ. 2013 Nov 4;347:f6153. doi: 10.1136/bmj.f6153.</citation>
    <PMID>24191270</PMID>
  </reference>
  <reference>
    <citation>Lubeek SF, Borgonjen RJ, van Vugt LJ, Olde Rikkert MG, van de Kerkhof PC, Gerritsen MJ. Improving the applicability of guidelines on nonmelanoma skin cancer in frail older adults: a multidisciplinary expert consensus and systematic review of current guidelines. Br J Dermatol. 2016 Nov;175(5):1003-1010. doi: 10.1111/bjd.14923. Epub 2016 Sep 13.</citation>
    <PMID>27484632</PMID>
  </reference>
  <reference>
    <citation>Karam I, Yao M, Heron DE, Poon I, Koyfman SA, Yom SS, Siddiqui F, Lartigau E, Cengiz M, Yamazaki H, Hara W, Phan J, Vargo JA, Lee V, Foote RL, Harter KW, Lee NY, Sahgal A, Lo SS. Survey of current practices from the International Stereotactic Body Radiotherapy Consortium (ISBRTC) for head and neck cancers. Future Oncol. 2017 Mar;13(7):603-613. doi: 10.2217/fon-2016-0403. Epub 2016 Nov 15.</citation>
    <PMID>27842456</PMID>
  </reference>
  <reference>
    <citation>Khan L, Tjong M, Raziee H, Lee J, Erler D, Chin L, Poon I. Role of stereotactic body radiotherapy for symptom control in head and neck cancer patients. Support Care Cancer. 2015 Apr;23(4):1099-103. doi: 10.1007/s00520-014-2421-y. Epub 2014 Oct 9.</citation>
    <PMID>25294656</PMID>
  </reference>
  <reference>
    <citation>Vargo JA, Ferris RL, Ohr J, Clump DA, Davis KS, Duvvuri U, Kim S, Johnson JT, Bauman JE, Gibson MK, Branstetter BF, Heron DE. A prospective phase 2 trial of reirradiation with stereotactic body radiation therapy plus cetuximab in patients with previously irradiated recurrent squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 2015 Mar 1;91(3):480-8. doi: 10.1016/j.ijrobp.2014.11.023. Epub 2015 Jan 30.</citation>
    <PMID>25680594</PMID>
  </reference>
  <reference>
    <citation>Heron DE, Ferris RL, Karamouzis M, Andrade RS, Deeb EL, Burton S, Gooding WE, Branstetter BF, Mountz JM, Johnson JT, Argiris A, Grandis JR, Lai SY. Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1493-500. doi: 10.1016/j.ijrobp.2008.12.075. Epub 2009 May 21.</citation>
    <PMID>19464819</PMID>
  </reference>
  <verification_date>June 2020</verification_date>
  <study_first_submitted>June 11, 2020</study_first_submitted>
  <study_first_submitted_qc>June 15, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 17, 2020</study_first_posted>
  <last_update_submitted>December 1, 2020</last_update_submitted>
  <last_update_submitted_qc>December 1, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">December 2, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Head and Neck Cancer</keyword>
  <keyword>Squamous Cell Cancer</keyword>
  <keyword>Squamous Skin Cancer</keyword>
  <keyword>Stereotactic Body Radiotherapy</keyword>
  <keyword>SBRT</keyword>
  <keyword>Radiation Therapy</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Carcinoma</mesh_term>
    <mesh_term>Carcinoma, Squamous Cell</mesh_term>
    <mesh_term>Squamous Cell Carcinoma of Head and Neck</mesh_term>
    <mesh_term>Head and Neck Neoplasms</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04435938
org study id: 8134
nct id: NCT04435938
lead sponsor: 
collaborator: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
To evaluate the tumour response rate of squamous cell carcinoma of the head and neck
      following stereotactic body radiotherapy (SBRT) of 45Gy in 5 fractions delivered once every
      3-4 days, such that treatment is completed within 15 days.
Cancers of the head and neck region account for approximately 4% of all new cancer cases.
      Primary skin cancers are the most common malignancy diagnosed in North America with the
      majority of tumours arising in the cervico-facial region.Together, these tumours comprise a
      high burden of illness and are often characterized by locally advanced, non-metastatic
      disease.

      Determining the optimal treatment for individual patients with advanced cervico-facial
      cancers of the skin or primary head and neck squamous cell carcinoma (HNSCC) is clinically
      challenging; standard treatments include combinations of surgery, radiation and chemotherapy,
      all of which are associated with high rates of acute toxicity and complications. A
      meta-analysis of randomized controlled trials did not demonstrate benefit with concurrent
      chemotherapy in patients over the age of 70 or with performance status ≥ 2, and it is
      recognized that the high burden of medical co-morbidities in HNSCC is associated with poorer
      prognosis. Some patients without distant metastases may be deemed to have 'incurable' disease
      due to very advanced tumours, recurrence, severe medical co-morbidities or frailty that
      prohibit the use of standard surgery, general anaesthetic and/or radiotherapy over 6-7 weeks.

      When conventional surgery and/or radiotherapy are not recommended by the multi-disciplinary
      team then patients may be treated with shorter, hypo-fractionated radiotherapy with the goal
      of symptom relief and local control but at the cost of a lower biological dose. Investigators
      at the Juravinski Cancer Centre published retrospective results from the '0-7-21' regimen
      using 24 Gy / 3 fractions which was well tolerated and provided temporary symptom relief in
      82% of patients but reported 6 month progression free survival of 39% within the irradiated
      field; a phase 2 study of previously untreated HNSCC patients deemed to have incurable
      disease used up to 42 Gy/12 fractions and demonstrated similar rates of initial response and
      symptom relief but a short progression free survival duration of 3.1 months. One study
      reported an institutional experience of palliative radiotherapy in newly diagnosed head and
      neck cancer patients who were deemed to have incurable disease and received a wide range of
      dose/fractionation regimens. The median radiation dose was 50 Gy and between 57-82% of
      patients were reported to have any radiological, clinical or symptomatic response to
      treatment. In these three studies, the patients were older with median ages of 71, 73, and 77
      years - and median survival was short 5.2, 5.7 and 6.2 months.

      With respect to squamous cell carcinoma (SCC) of the skin, there is limited evidence to guide
      treatment in patients with unresectable or medically inoperable disease, particularly in the
      head and neck region. There is a need for prospective data on non-surgical treatment options
      for frail older adults which improve efficacy while limiting the treatment burden.

      SBRT can limit the number of treatments while delivering a higher, potentially curative dose.
      An international consortium of 15 high volume cancer centres reported on a survey of
      practices using SBRT for head and neck cancers. There was heterogeneity in the indications,
      techniques and doses reported by various institutions. The most common indication was in the
      setting of recurrent disease and reported doses were in the range of 35-50 Gy in 3-5
      fractions. Several institutions reported 1-2 year local control rates of 65-90% with SBRT and
      acceptable levels of toxicity. To our knowledge, there are no prospective clinical studies
      evaluating tumour response, toxicity and quality of life in previously unirradiated patients.

      The goal of the current study is to prospectively evaluate tumour response, toxicity and
      patient quality of life in patients with HNSCC undergoing SBRT.
allocation: N/A
intervention model: Single Group Assignment
intervention model description: Eligible and consenting patients will be treated with the dose prescribed in the study of 45Gy in 5 fractions, delivered once every 3-4 days, such that treatment is completed within 15 days (Exceptions: treatment duration of up to 18 days will be allowed to account for cancer centre closures and unforeseen patient issues). Using the Simon optimal two-stage design, 11 patients will be recruited in the first stage. If 6 or less patients have a response, the study will be stopped at the end of stage I, however, if 7 or more patients have a response the study will continue to stage II, in which an additional 27 patients (for a total of 38) will be recruited. At the end of stage II, if 26 or less patients have a response, then H0 will be accepted and the treatment regimen deemed not worthy of further study, however, if 27 or more patients have a response, the treatment regimen will be recommended for further study in phase III.
primary purpose: Treatment
masking: None (Open Label)
measure: Tumour response rate
time frame: The best overall response across all time points during the study period - up to 24 months after completion of SBRT.
description: Tumour response rate defined as complete or partial response according to Tumour response rate will be defined by RECIST 1.1 criteria
measure: Number of participants with Acute and Late Toxicity
time frame: Up to 24 months after completion of SBRT
description: Acute toxicity (during and up to 3 months from the end of treatment) and late toxicity (after 3 months) adverse effects secondary to SBRT treatment will be graded according to the Common Terminology Criteria for Adverse Events (CTCAE v5.0) scale.
measure: Local Control
time frame: Determination of local recurrence will be based on based on RECIST criteria 1.1 (see section 11.3 below) and assessed on MRI or CT scan imaging at 12 weeks and any additional imaging/clinical assessments performed during the study.
description: The absence of local progression of disease of the target lesions during the study period.
measure: Quality of Life as measured by the FACT-HN questionnaire
time frame: The FACT-HN Quesionnaire will be administered at Baseline, once during treatment, 6 weeks, 3, 6, 12 months post SBRT treatment. Higher scores represent better qualtiy of life.
description: Assessed using the FACT-HN questionnaire
arm group label: Stereotactic Body Radiotherapy (SBRT)
arm group type: Experimental
description: The dose prescribed in the study will be 45Gy in 5 fractions, delivered once every 3-4 days, such that treatment is completed within 15 days. (e.g. treatment given on Monday/Thursday/Mon/Thurs/Mon) (Exceptions: treatment duration of up to 18 days will be allowed to account for cancer centre closures and unforeseen patient issues.)
intervention type: Radiation
intervention name: Stereotactic Body Radiotherapy (SBRT)
description: 45 Gy in 5 fractions delivered once every 3-4 days
arm group label: Stereotactic Body Radiotherapy (SBRT)
criteria: 
gender: All
minimum age: 60 Years
maximum age: N/A
healthy volunteers: No
last name: Justin Lee, MD
role: Principal Investigator
affiliation: Juravinski Cancer Centre
last name: Shelley Chambers, MA
phone: 905-387-9711
phone ext: 64510
email: chamberss@hhsc.ca
last name: Thivya Jeyachanthiran
phone: 905-387-9495
email: jeyachanth@hhsc.ca
facility: 
status: Recruiting
contact: 
contact backup: 
investigator: 
investigator: 
investigator: 
country: Canada
url: http://www.cancer.gov/
description: Cancer Statistics. National Cancer Institute.
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responsible party type: Sponsor
mesh term: Carcinoma
mesh term: Carcinoma, Squamous Cell
mesh term: Squamous Cell Carcinoma of Head and Neck
mesh term: Head and Neck Neoplasms