<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04416841</url>
  </required_header>
  <id_info>
    <org_study_id>FujianUTCM</org_study_id>
    <nct_id>NCT04416841</nct_id>
  </id_info>
  <brief_title>Tai Chi Chuan as Rehabilitation Program for Mild Cognitive Impairment in Type 2 Diabetes Mellitus Patients</brief_title>
  <official_title>Efficacy of Tai Chi Chuan on Cognitive Function in Type 2 Diabetes Mellitus Patients Accompanied With Mild Cognitive Impairment</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Jing Tao</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Second Affiliated Hospital of Heilongjiang University of Chinese Medicine</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Bao'an District People's Hospital of Shenzhen</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Xiyuan Hospital of China Academy of Chinese Medical Sciences</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Peking University</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>University of Electronic Science and Technology of China</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Fujian University of Traditional Chinese Medicine</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The patients with type 2 diabetes mellitus (T2DM) is expected to rise to 439 million in 2030,&#xD;
      accounting for 7.7% the population in the world. There are nearly 10 million T2DM patients&#xD;
      with mild cognitive impairment (MCI) among people over 65 years old , accounting for about 8%&#xD;
      of the people over 65 years old in China. The medical cost for patients with T2DM/MCI is 2.5&#xD;
      to 4 times higher than those without T2DM. And T2DM will increase the risk of cognitive&#xD;
      impairment, and lead to various complications which will bring serious social and medical&#xD;
      economic burden.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      It is critically important to identify effective treatments to enhance functional status of&#xD;
      T2DM/MCI patients. Exercise has been shown to be beneficial for T2DM/MCI patients. As a&#xD;
      Chinese traditional mind-body exercise that consists of both physical and mediation&#xD;
      components, Tai Chi Chuan has been proved to be helpful in global cognition, memory,&#xD;
      executive function and attention of MCI, and blood sugar of T2DM. However, the evidence of&#xD;
      the effect of Tai Chi Chuan on T2DM/MCI patients is limited. The purpose of this study is to&#xD;
      explore the effect of Tai Chi Chuan treating T2DM/MCI patients in cognitive function,&#xD;
      balance, motor and sensation function, blood sugar, biochemistry profile and quality of life.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">June 3, 2020</start_date>
  <completion_date type="Actual">August 20, 2022</completion_date>
  <primary_completion_date type="Actual">March 15, 2022</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Global cognition-Montreal Cognitive Assessment at 36 Weeks</measure>
    <time_frame>36 weeks (post-intervention follow-up)</time_frame>
    <description>Montreal Cognitive Assessment</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Global cognition-Montreal Cognitive Assessment at 24 weeks</measure>
    <time_frame>24 weeks (post-intervention)</time_frame>
    <description>Montreal Cognitive Assessment</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Memory function-Wechsler Memory Scale at 24, 36 Weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Wechsler Memory Scale</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Digital Symbol test at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Digital Symbol test</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Trial Making Test part B at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Trial Making Test part B</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Stroop color word test at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Stroop color word test</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Boston naming test at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Boston naming test</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Rey-Osterrieth complex graphics test at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Rey-Osterrieth complex graphics test</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Multi-task balance test: Time up and go test; Time up and go test + cognitive task;Time up and go test + motor task;Time up and go test + cognitive task + motor task at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Time up and go test; Time up and go test + cognitive task (animal naming); Time up and go test + motor task (holding a cup of water); Time up and go test + cognitive task + motor task.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Functional reach test at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Functional reach test</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>One leg stance test at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>One leg stance test</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Grip strength at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Grip strength</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Five times sit-to-stand test at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Five times sit-to-stand test</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Sensation function at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Tactile sensation; Two-point discrimination sensation; Vibration sensation.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Fall efficiency-Modified Falls Efficacy Scale at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Modified Falls Efficacy Scale</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Quality of life-Medical Outcomes Study 36-item Short-Form Health Survey at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Medical Outcomes Study 36-item Short-Form Health Survey (SF-36)</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Blood glucose metabolism index at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>fasting blood glucose; glycosylated hemoglobin; fasting insulin</description>
  </other_outcome>
  <other_outcome>
    <measure>Blood lipid metabolism index at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>total cholesterol (TC); total triglyceride (TG); low density lipoprotein (LDL),;high density lipoprotein (HDL).</description>
  </other_outcome>
  <other_outcome>
    <measure>Circulating levels of AGE and sRAGE at 24, 36 weeks</measure>
    <time_frame>24, 36 weeks</time_frame>
    <description>Circulating levels of AGE and sRAGE</description>
  </other_outcome>
  <other_outcome>
    <measure>functional Magnetic Resonance Imaging (fMRI)</measure>
    <time_frame>baseline, 24 weeks</time_frame>
    <description>functional Magnetic Resonance Imaging</description>
  </other_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Actual">328</enrollment>
  <condition>Diabetes Mellitus, Type 2</condition>
  <condition>Cognitive Dysfunction</condition>
  <arm_group>
    <arm_group_label>Tai Chi Chuan Group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>In addition to conventional medical treatment, participants will receive 3 sessions of 1-hour Tai Chi Chuan training per week for 24 weeks and standard diabetic care education.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Fitness Walking Group</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>In addition to conventional medical treatment, participants will receive 3 sessions of 1-hour fitness walking training per week for 24 weeks and standard diabetic care education</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Control group</arm_group_label>
    <arm_group_type>Other</arm_group_type>
    <description>In addition to conventional medical treatment, participants will receive standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.</description>
  </arm_group>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Tai Chi Chuan</intervention_name>
    <description>Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 3sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.</description>
    <arm_group_label>Tai Chi Chuan Group</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Fitness Walking</intervention_name>
    <description>Participants would take fitness walking training 1 hour/session, 3sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes fitness walking and 10 minutes cool-down exercises in the fitness walking training, the exercise intensity was 50% to 70% of the maximum heart rate. Besides, they would also take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.</description>
    <arm_group_label>Fitness Walking Group</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Standard Diabetic Care Education</intervention_name>
    <description>Participants would take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.</description>
    <arm_group_label>Control group</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. clinician diagnosis of T2DM;&#xD;
&#xD;
          2. presence of mild cognitive impairment, not demented;&#xD;
&#xD;
          3. age ≥ 60 years old;&#xD;
&#xD;
          4. did not engage in regular exercise in the last three months (at least 3 times a week,&#xD;
             at least 20 minutes of regular exercise each time);&#xD;
&#xD;
          5. informed consent and voluntary participation.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. cognitive impairment caused by other reasons, taking drugs, poisoning, etc;&#xD;
&#xD;
          2. presence of medical conditions that unable or unsafe to exercise, such as depression&#xD;
             symptoms, uncontrolled hypertension/ blood pressure/ blood glucose, nervous system&#xD;
             diseases(stroke, Parkinson's disease, etc), musculoskeletal system diseases(arthritis,&#xD;
             history of hip and/or knee joint replacement, etc), etc;&#xD;
&#xD;
          3. participating in other experiments that influence this study.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>60 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>Fujian University of Traditional Chinese Medicine</name>
      <address>
        <city>Fuzhou</city>
        <state>Fujian</state>
        <zip>350122</zip>
        <country>China</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
  <reference>
    <citation>You Y, Liu Z, Chen Y, Xu Y, Qin J, Guo S, Huang J, Tao J. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol. 2021 Jun;58(6):671-685. doi: 10.1007/s00592-020-01648-9. Epub 2021 Jan 8.</citation>
    <PMID>33417039</PMID>
  </reference>
  <reference>
    <citation>Qin J, Chen Y, Guo S, You Y, Xu Y, Wu J, Liu Z, Huang J, Chen L, Tao J. Effect of Tai Chi on Quality of Life, Body Mass Index, and Waist-Hip Ratio in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2021 Jan 19;11:543627. doi: 10.3389/fendo.2020.543627. eCollection 2020.</citation>
    <PMID>33542702</PMID>
  </reference>
  <reference>
    <citation>Guo S, Xu Y, Qin J, Chen Y, You Y, Tao J, Liu Z, Huang J. Effect of tai chi on glycaemic control, lipid metabolism and body composition in adults with type 2 diabetes: A meta-analysis and systematic review. J Rehabil Med. 2021 Mar 22;53(3):jrm00165. doi: 10.2340/16501977-2799.</citation>
    <PMID>33594445</PMID>
  </reference>
  <reference>
    <citation>Bai A, Tao L, Huang J, Tao J, Liu J. Effects of physical activity on cognitive function among patients with diabetes in China: a nationally longitudinal study. BMC Public Health. 2021 Mar 11;21(1):481. doi: 10.1186/s12889-021-10537-x.</citation>
    <PMID>33706749</PMID>
  </reference>
  <reference>
    <citation>Yin L, Qin J, Chen Y, Xie J, Hong C, Huang J, Xu Y, Liu Z, Tao J. Impact of Body Mass Index on Static Postural Control in Adults With and Without Diabetes: A Cross-Sectional Study. Front Endocrinol (Lausanne). 2021 Dec 24;12:768185. doi: 10.3389/fendo.2021.768185. eCollection 2021.</citation>
    <PMID>35002958</PMID>
  </reference>
  <reference>
    <citation>Xie J, Yin L, Huang J, Xu Y, Chen Y, Qin J, Liu Z, Tao J. Correlation between impaired hemodynamic response and cardiopulmonary fitness in middle-aged type 2 diabetes mellitus patients: a case-control study. Eur J Appl Physiol. 2022 Oct;122(10):2295-2303. doi: 10.1007/s00421-022-05008-z. Epub 2022 Jul 20.</citation>
    <PMID>35859047</PMID>
  </reference>
  <verification_date>September 2022</verification_date>
  <study_first_submitted>May 26, 2020</study_first_submitted>
  <study_first_submitted_qc>June 1, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 4, 2020</study_first_posted>
  <last_update_submitted>September 20, 2022</last_update_submitted>
  <last_update_submitted_qc>September 20, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">September 22, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>Fujian University of Traditional Chinese Medicine</investigator_affiliation>
    <investigator_full_name>Jing Tao</investigator_full_name>
    <investigator_title>PhD</investigator_title>
  </responsible_party>
  <keyword>Tai Chi Chuan</keyword>
  <keyword>Cognitive Function</keyword>
  <keyword>Postural Balance</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Diabetes Mellitus</mesh_term>
    <mesh_term>Diabetes Mellitus, Type 2</mesh_term>
    <mesh_term>Cognitive Dysfunction</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04416841
org study id: FujianUTCM
nct id: NCT04416841
lead sponsor: 
collaborator: 
collaborator: 
collaborator: 
collaborator: 
collaborator: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
The patients with type 2 diabetes mellitus (T2DM) is expected to rise to 439 million in 2030,
      accounting for 7.7% the population in the world. There are nearly 10 million T2DM patients
      with mild cognitive impairment (MCI) among people over 65 years old , accounting for about 8%
      of the people over 65 years old in China. The medical cost for patients with T2DM/MCI is 2.5
      to 4 times higher than those without T2DM. And T2DM will increase the risk of cognitive
      impairment, and lead to various complications which will bring serious social and medical
      economic burden.
It is critically important to identify effective treatments to enhance functional status of
      T2DM/MCI patients. Exercise has been shown to be beneficial for T2DM/MCI patients. As a
      Chinese traditional mind-body exercise that consists of both physical and mediation
      components, Tai Chi Chuan has been proved to be helpful in global cognition, memory,
      executive function and attention of MCI, and blood sugar of T2DM. However, the evidence of
      the effect of Tai Chi Chuan on T2DM/MCI patients is limited. The purpose of this study is to
      explore the effect of Tai Chi Chuan treating T2DM/MCI patients in cognitive function,
      balance, motor and sensation function, blood sugar, biochemistry profile and quality of life.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Single (Outcomes Assessor)
measure: Global cognition-Montreal Cognitive Assessment at 36 Weeks
time frame: 36 weeks (post-intervention follow-up)
description: Montreal Cognitive Assessment
measure: Global cognition-Montreal Cognitive Assessment at 24 weeks
time frame: 24 weeks (post-intervention)
description: Montreal Cognitive Assessment
measure: Memory function-Wechsler Memory Scale at 24, 36 Weeks
time frame: 24, 36 weeks
description: Wechsler Memory Scale
measure: Digital Symbol test at 24, 36 weeks
time frame: 24, 36 weeks
description: Digital Symbol test
measure: Trial Making Test part B at 24, 36 weeks
time frame: 24, 36 weeks
description: Trial Making Test part B
measure: Stroop color word test at 24, 36 weeks
time frame: 24, 36 weeks
description: Stroop color word test
measure: Boston naming test at 24, 36 weeks
time frame: 24, 36 weeks
description: Boston naming test
measure: Rey-Osterrieth complex graphics test at 24, 36 weeks
time frame: 24, 36 weeks
description: Rey-Osterrieth complex graphics test
measure: Multi-task balance test: Time up and go test; Time up and go test + cognitive task;Time up and go test + motor task;Time up and go test + cognitive task + motor task at 24, 36 weeks
time frame: 24, 36 weeks
description: Time up and go test; Time up and go test + cognitive task (animal naming); Time up and go test + motor task (holding a cup of water); Time up and go test + cognitive task + motor task.
measure: Functional reach test at 24, 36 weeks
time frame: 24, 36 weeks
description: Functional reach test
measure: One leg stance test at 24, 36 weeks
time frame: 24, 36 weeks
description: One leg stance test
measure: Grip strength at 24, 36 weeks
time frame: 24, 36 weeks
description: Grip strength
measure: Five times sit-to-stand test at 24, 36 weeks
time frame: 24, 36 weeks
description: Five times sit-to-stand test
measure: Sensation function at 24, 36 weeks
time frame: 24, 36 weeks
description: Tactile sensation; Two-point discrimination sensation; Vibration sensation.
measure: Fall efficiency-Modified Falls Efficacy Scale at 24, 36 weeks
time frame: 24, 36 weeks
description: Modified Falls Efficacy Scale
measure: Quality of life-Medical Outcomes Study 36-item Short-Form Health Survey at 24, 36 weeks
time frame: 24, 36 weeks
description: Medical Outcomes Study 36-item Short-Form Health Survey (SF-36)
measure: Blood glucose metabolism index at 24, 36 weeks
time frame: 24, 36 weeks
description: fasting blood glucose; glycosylated hemoglobin; fasting insulin
measure: Blood lipid metabolism index at 24, 36 weeks
time frame: 24, 36 weeks
description: total cholesterol (TC); total triglyceride (TG); low density lipoprotein (LDL),;high density lipoprotein (HDL).
measure: Circulating levels of AGE and sRAGE at 24, 36 weeks
time frame: 24, 36 weeks
description: Circulating levels of AGE and sRAGE
measure: functional Magnetic Resonance Imaging (fMRI)
time frame: baseline, 24 weeks
description: functional Magnetic Resonance Imaging
arm group label: Tai Chi Chuan Group
arm group type: Experimental
description: In addition to conventional medical treatment, participants will receive 3 sessions of 1-hour Tai Chi Chuan training per week for 24 weeks and standard diabetic care education.
arm group label: Fitness Walking Group
arm group type: Active Comparator
description: In addition to conventional medical treatment, participants will receive 3 sessions of 1-hour fitness walking training per week for 24 weeks and standard diabetic care education
arm group label: Control group
arm group type: Other
description: In addition to conventional medical treatment, participants will receive standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.
intervention type: Behavioral
intervention name: Tai Chi Chuan
description: Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 3sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.
arm group label: Tai Chi Chuan Group
intervention type: Behavioral
intervention name: Fitness Walking
description: Participants would take fitness walking training 1 hour/session, 3sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes fitness walking and 10 minutes cool-down exercises in the fitness walking training, the exercise intensity was 50% to 70% of the maximum heart rate. Besides, they would also take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.
arm group label: Fitness Walking Group
intervention type: Behavioral
intervention name: Standard Diabetic Care Education
description: Participants would take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.
arm group label: Control group
criteria: 
gender: All
minimum age: 60 Years
maximum age: N/A
healthy volunteers: No
facility: 
country: China
citation: You Y, Liu Z, Chen Y, Xu Y, Qin J, Guo S, Huang J, Tao J. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol. 2021 Jun;58(6):671-685. doi: 10.1007/s00592-020-01648-9. Epub 2021 Jan 8.
PMID: 33417039
citation: Qin J, Chen Y, Guo S, You Y, Xu Y, Wu J, Liu Z, Huang J, Chen L, Tao J. Effect of Tai Chi on Quality of Life, Body Mass Index, and Waist-Hip Ratio in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2021 Jan 19;11:543627. doi: 10.3389/fendo.2020.543627. eCollection 2020.
PMID: 33542702
citation: Guo S, Xu Y, Qin J, Chen Y, You Y, Tao J, Liu Z, Huang J. Effect of tai chi on glycaemic control, lipid metabolism and body composition in adults with type 2 diabetes: A meta-analysis and systematic review. J Rehabil Med. 2021 Mar 22;53(3):jrm00165. doi: 10.2340/16501977-2799.
PMID: 33594445
citation: Bai A, Tao L, Huang J, Tao J, Liu J. Effects of physical activity on cognitive function among patients with diabetes in China: a nationally longitudinal study. BMC Public Health. 2021 Mar 11;21(1):481. doi: 10.1186/s12889-021-10537-x.
PMID: 33706749
citation: Yin L, Qin J, Chen Y, Xie J, Hong C, Huang J, Xu Y, Liu Z, Tao J. Impact of Body Mass Index on Static Postural Control in Adults With and Without Diabetes: A Cross-Sectional Study. Front Endocrinol (Lausanne). 2021 Dec 24;12:768185. doi: 10.3389/fendo.2021.768185. eCollection 2021.
PMID: 35002958
citation: Xie J, Yin L, Huang J, Xu Y, Chen Y, Qin J, Liu Z, Tao J. Correlation between impaired hemodynamic response and cardiopulmonary fitness in middle-aged type 2 diabetes mellitus patients: a case-control study. Eur J Appl Physiol. 2022 Oct;122(10):2295-2303. doi: 10.1007/s00421-022-05008-z. Epub 2022 Jul 20.
PMID: 35859047
responsible party type: Sponsor-Investigator
investigator affiliation: Fujian University of Traditional Chinese Medicine
investigator full name: Jing Tao
investigator title: PhD
mesh term: Diabetes Mellitus
mesh term: Diabetes Mellitus, Type 2
mesh term: Cognitive Dysfunction