<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04450433</url>
  </required_header>
  <id_info>
    <org_study_id>Liuhuadong's Research Group</org_study_id>
    <nct_id>NCT04450433</nct_id>
  </id_info>
  <brief_title>Functional Study of Metabolites in Patients With Aortic Dissection</brief_title>
  <official_title>Functional Study of Metabolites in Patients With Aortic Dissection</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Shenzhen People's Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Shenzhen People's Hospital</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Research on metabolites in patients with aortic dissection, with a view to finding products&#xD;
      with high or low metabolism in patients with aortic dissection, looking for metabolic factors&#xD;
      related to the onset of aortic dissection, and further verifying the role of metabolic&#xD;
      factors in disease through functional verification The role of formation, and ultimately&#xD;
      explore the early screening of potential aortic dissection patients&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">November 1, 2019</start_date>
  <completion_date type="Anticipated">October 30, 2020</completion_date>
  <primary_completion_date type="Anticipated">July 30, 2020</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Control</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Differential expression of metabolites in two groups of patients</measure>
    <time_frame>2019-11----2021.01</time_frame>
    <description>Differential expression of metabolites in the two groups of patients, looking for metabolic factors related to the incidence of aortic dissection, and further verifying the function of metabolites through functional methods, with a view to finding high-risk metabolic factors for patients with aortic dissection</description>
  </primary_outcome>
  <number_of_groups>3</number_of_groups>
  <enrollment type="Anticipated">1</enrollment>
  <condition>Aortic Dissection</condition>
  <arm_group>
    <arm_group_label>Baseline table of patients</arm_group_label>
  </arm_group>
  <arm_group>
    <arm_group_label>Differential metabolites of two groups of control patients</arm_group_label>
  </arm_group>
  <arm_group>
    <arm_group_label>Functional verification of differential metabolites</arm_group_label>
  </arm_group>
  <intervention>
    <intervention_type>Diagnostic Test</intervention_type>
    <intervention_name>aortic dissection and healthy people</intervention_name>
    <description>Differential expression of metabolites in patients with aortic dissection and healthy people</description>
    <arm_group_label>Baseline table of patients</arm_group_label>
    <arm_group_label>Differential metabolites of two groups of control patients</arm_group_label>
    <arm_group_label>Functional verification of differential metabolites</arm_group_label>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        30 patients with aortic dissection and 15 healthy people&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  patients with Aortic dissection&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Sepsis&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>30 Years</minimum_age>
    <maximum_age>80 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_contact>
    <last_name>Huadong Liu</last_name>
    <phone>13724397998</phone>
    <email>lhd2578@163.com</email>
  </overall_contact>
  <location>
    <facility>
      <name>Shenzhen People's Hospital</name>
      <address>
        <city>Shenzhen</city>
        <state>Guangdong</state>
        <zip>518020</zip>
        <country>China</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Huadong Liu, PhD</last_name>
      <phone>13724397998</phone>
      <email>lhd2578@163.com</email>
    </contact>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
  <verification_date>June 2020</verification_date>
  <study_first_submitted>June 24, 2020</study_first_submitted>
  <study_first_submitted_qc>June 24, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 29, 2020</study_first_posted>
  <last_update_submitted>June 24, 2020</last_update_submitted>
  <last_update_submitted_qc>June 24, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">June 29, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Aortic Dissection</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04450433
org study id: Liuhuadong's Research Group
nct id: NCT04450433
lead sponsor: 
is fda regulated drug: No
is fda regulated device: No
Research on metabolites in patients with aortic dissection, with a view to finding products
      with high or low metabolism in patients with aortic dissection, looking for metabolic factors
      related to the onset of aortic dissection, and further verifying the role of metabolic
      factors in disease through functional verification The role of formation, and ultimately
      explore the early screening of potential aortic dissection patients
observational model: Case-Control
time perspective: Prospective
measure: Differential expression of metabolites in two groups of patients
time frame: 2019-11----2021.01
description: Differential expression of metabolites in the two groups of patients, looking for metabolic factors related to the incidence of aortic dissection, and further verifying the function of metabolites through functional methods, with a view to finding high-risk metabolic factors for patients with aortic dissection
arm group label: Baseline table of patients
arm group label: Differential metabolites of two groups of control patients
arm group label: Functional verification of differential metabolites
intervention type: Diagnostic Test
intervention name: aortic dissection and healthy people
description: Differential expression of metabolites in patients with aortic dissection and healthy people
arm group label: Baseline table of patients
arm group label: Differential metabolites of two groups of control patients
arm group label: Functional verification of differential metabolites
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 30 Years
maximum age: 80 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Huadong Liu
phone: 13724397998
email: lhd2578@163.com
facility: 
status: Recruiting
contact: 
country: China
responsible party type: Sponsor
mesh term: Aortic Dissection
sharing ipd: Undecided