<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04492657</url>
  </required_header>
  <id_info>
    <org_study_id>NSFC-8191001159</org_study_id>
    <nct_id>NCT04492657</nct_id>
  </id_info>
  <brief_title>Study on the Compensatory Mechanism of Iodine Nutrition and the Optimal Intake Level of Lactating Women</brief_title>
  <official_title>Study on the Compensatory Mechanism of Iodine Nutrition and the Optimal Intake Level of Lactating Women</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Tianjin Medical University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Tianjin Medical University</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Due to the lack of direct evidence of optimal iodine intake of Chinese children, pregnant and&#xD;
      lactating women and infants were found during the recent revision of Chinese dietary&#xD;
      reference intakes (DRIs) of iodine in 2013 by the applicant Pro. Zhang, and no systematical&#xD;
      research about compensatory mechanism of iodine nutrition in lactating women was found yet.&#xD;
      Previous study funded by United Nations International Children's Emergency Fund (UNICEF)&#xD;
      cooperated with the international experts on iodine and key project of national natural&#xD;
      science foundation of China under the guidance of Pro. Zhang, had obtained the safe intake&#xD;
      range of iodine from children and pregnant women, more than 10 joint papers were published,&#xD;
      which laid the foundation of population study and international cooperation.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Studies indicate lactating women and their infants are the most vulnerable population to the&#xD;
      adverse effects of iodine deficiency and excess, and because of the complexity of the study&#xD;
      of lactating mothers and infants and the difficulty of sample collection, it is proposed to&#xD;
      overcome this problem with the help of the advanced dried blood spot technique and iodine&#xD;
      balance study method from the panel of Iodine Global Network (IGN). Investigators intend to&#xD;
      recruit 900 late pregnant women in Tianjin, Hebei and Shandong;then establishing a dynamic&#xD;
      cohort of breastfeeding mother-infant to 6 months after delivery to investigate the&#xD;
      physiological compensatory mechanism of iodine nutrition in lactating women with the&#xD;
      combination of animal experiment; On the other hand, 180 exclusively breastfeeding mother and&#xD;
      infants within postpartum 0-6 months, will be selected to participate the iodine balance&#xD;
      study.&#xD;
&#xD;
      Optimized method of iodine balance experiment of infants by both foreign partner and Pro.&#xD;
      Zhang's team will be adopted to obtain the first iodine balance value of Chinese lactating&#xD;
      women and infants,providing the direct evidence for the revision of DRIs in lactating women&#xD;
      and infants, and guide the lactating women proper iodine supplementation to meet the&#xD;
      requirements of both mothers and infants.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Recruiting</overall_status>
  <start_date type="Actual">January 1, 2020</start_date>
  <completion_date type="Anticipated">December 31, 2024</completion_date>
  <primary_completion_date type="Anticipated">December 31, 2021</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Other</observational_model>
    <time_perspective>Cross-Sectional</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Disposable random urine</measure>
    <time_frame>baseline</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Venous blood</measure>
    <time_frame>baseline</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Water iodine intake</measure>
    <time_frame>baseline</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Salt iodine concentration</measure>
    <time_frame>baseline</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Colostrum</measure>
    <time_frame>1 week</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Mother and child urine randomly at one time</measure>
    <time_frame>1 week</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Neonatal heel blood</measure>
    <time_frame>1 week</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroglobulin(TG)</measure>
    <time_frame>1 week</time_frame>
    <description>ug/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroid-stimulating hormone</measure>
    <time_frame>1 week</time_frame>
    <description>mIU/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Infant disposable random urine</measure>
    <time_frame>4 weeks</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Infant disposable random urine</measure>
    <time_frame>24 weeks</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Infant disposable random urine</measure>
    <time_frame>12 weeks</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>24 h urine</measure>
    <time_frame>4 weeks</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>24 h urine</measure>
    <time_frame>12 weeks</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>24 h urine</measure>
    <time_frame>24 weeks</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Urinary iodine excretion</measure>
    <time_frame>4 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Urinary iodine excretion</measure>
    <time_frame>12 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Urinary iodine excretion</measure>
    <time_frame>24 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Milk output</measure>
    <time_frame>4 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Milk output</measure>
    <time_frame>12 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Milk output</measure>
    <time_frame>24 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Milk iodine excretion</measure>
    <time_frame>4 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Milk iodine excretion</measure>
    <time_frame>12 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Milk iodine excretion</measure>
    <time_frame>24 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Average iodine intake</measure>
    <time_frame>4 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Average iodine intake</measure>
    <time_frame>12 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Average iodine intake</measure>
    <time_frame>24 weeks</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroid volume</measure>
    <time_frame>1 week</time_frame>
    <description>cm³</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroid volume</measure>
    <time_frame>4 weeks</time_frame>
    <description>cm³</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroid volume</measure>
    <time_frame>12 weeks</time_frame>
    <description>cm³</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroid volume</measure>
    <time_frame>24 weeks</time_frame>
    <description>cm³</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroid nodule</measure>
    <time_frame>1 week</time_frame>
    <description>cm³</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroid nodule</measure>
    <time_frame>4 weeks</time_frame>
    <description>cm³</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroid nodule</measure>
    <time_frame>12 weeks</time_frame>
    <description>cm³</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Thyroid nodule</measure>
    <time_frame>24 weeks</time_frame>
    <description>cm³</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Dried blood spot(DBS)</measure>
    <time_frame>3 days</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Dried blood spot(DBS)</measure>
    <time_frame>12 weeks</time_frame>
    <description>μg/L</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diet iodine intake</measure>
    <time_frame>1 week</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Fecal iodine excretion</measure>
    <time_frame>1 week</time_frame>
    <description>μg/day</description>
  </primary_outcome>
  <enrollment type="Anticipated">600</enrollment>
  <condition>Nutritional Requirements</condition>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>no intervention</intervention_name>
    <description>Natural exposure of iodine.</description>
  </intervention>
  <biospec_retention>Samples Without DNA</biospec_retention>
  <biospec_descr>
    <textblock>
      blood,urine,breast milk&#xD;
    </textblock>
  </biospec_descr>
  <eligibility>
    <study_pop>
      <textblock>
        Women in the third trimester (18-40 years old), lactating women (38-42 weeks of gestation)&#xD;
        and infants (0-6 months), all from Tianjin, Hebei and Shandong&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Women in their third trimester:⑴Aged 18-40, who have lived in the area for 1&#xD;
             year;⑵Single pregnancy;⑶Those who have no special dietary habits;&#xD;
&#xD;
          -  Lactating woman:⑴Breastfeeding a child;⑵Normal thyroid function during pregnancy;⑶Term&#xD;
             delivery (38-42 weeks of gestation);&#xD;
&#xD;
          -  Infants and young children:⑴0-6 months;⑵Breastfeeding;⑶Full term (38-42 weeks of&#xD;
             gestation);⑷Normal birth weight (2500-4000g);⑸The thyroid-stimulating hormone (TSH)&#xD;
             value of heel blood was normal;⑹Apgar score 8.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Women in their third trimester:⑴Smoking or drinking;⑵Iodized drugs or contrast agents&#xD;
             have been used in the past year;⑶A history of thyroid disease, autoimmune disease,&#xD;
             endocrine disease, heart disease, chronic disease or family hereditary disease, etc;&#xD;
&#xD;
          -  Lactating woman:⑴A history of thyroid disease, autoimmune disease, endocrine disease,&#xD;
             heart disease, chronic disease or family hereditary disease, etc;&#xD;
&#xD;
          -  Infants and young children:⑴Have pathological jaundice, autoimmune disease, congenital&#xD;
             heart disease and other diseases.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>1 Day</minimum_age>
    <maximum_age>40 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>JianQiang Lai</last_name>
    <role>Principal Investigator</role>
    <affiliation>Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention</affiliation>
  </overall_official>
  <overall_official>
    <last_name>XueSong Wang</last_name>
    <role>Principal Investigator</role>
    <affiliation>Shandong Institute of Endemic Disease Control and Prevention</affiliation>
  </overall_official>
  <overall_official>
    <last_name>YiFan Duan</last_name>
    <role>Principal Investigator</role>
    <affiliation>Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention</affiliation>
  </overall_official>
  <overall_official>
    <last_name>GuiJun Tan</last_name>
    <role>Principal Investigator</role>
    <affiliation>Tianjin Medical University</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Wen Chen</last_name>
    <role>Principal Investigator</role>
    <affiliation>Tianjin Medical University</affiliation>
  </overall_official>
  <overall_official>
    <last_name>YanTing Chen</last_name>
    <role>Principal Investigator</role>
    <affiliation>Tianjin Medical University</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Min Gao</last_name>
    <role>Principal Investigator</role>
    <affiliation>Tianjin Medical University</affiliation>
  </overall_official>
  <overall_official>
    <last_name>ZiYun Pan</last_name>
    <role>Principal Investigator</role>
    <affiliation>Tianjin Medical University</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Michael B Zimmermann, doctorate</last_name>
    <role>Study Chair</role>
    <affiliation>Swiss federal institute of Technology (ETH)</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Elizabeth N Pearce, doctorate</last_name>
    <role>Study Chair</role>
    <affiliation>Boston University School of Medicine; Iodine Global Network (IGN)</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Maria Andersson, doctorate</last_name>
    <role>Study Chair</role>
    <affiliation>Swiss federal institute of Technology (ETH); Iodine Global Network (IGN)</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>WanQi Zhang, doctorate</last_name>
    <phone>022-83336595</phone>
    <email>wqzhang@tmu.edu.cn</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>ying Ye</last_name>
    <phone>022-83336717</phone>
    <email>yeying@tmu.edu.cn</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Boston University School of Medicine; Iodine Global Network (IGN)</name>
      <address>
        <city>Boston</city>
        <state>Massachusetts</state>
        <zip>02101-02117</zip>
        <country>United States</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Elizabeth N Pearce</last_name>
      <phone>617-414-1348</phone>
      <email>elizabeth.pearce@bmc.org</email>
    </contact>
  </location>
  <location>
    <facility>
      <name>Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention</name>
      <address>
        <city>Beijing</city>
        <country>China</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>WanQi Zhang</last_name>
      <phone>022-83336595</phone>
      <email>wqzhang@tmu.edu.cn</email>
    </contact>
    <contact_backup>
      <last_name>ying Ye</last_name>
      <phone>022-83336717</phone>
      <email>yeying@tmu.edu.cn</email>
    </contact_backup>
  </location>
  <location>
    <facility>
      <name>Shandong Institute of Endemic Disease Control and Prevention</name>
      <address>
        <city>Shandong</city>
        <country>China</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Zhang WanQi</last_name>
      <phone>022-83336595</phone>
      <email>wqzhang@tmu.edu.cn</email>
    </contact>
    <contact_backup>
      <last_name>Ye ying</last_name>
      <phone>022-83336717</phone>
      <email>yeying@tmu.edu.cn</email>
    </contact_backup>
  </location>
  <location>
    <facility>
      <name>Swiss federal institute of Technology (ETH)</name>
      <address>
        <city>Zurich</city>
        <country>Switzerland</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Michael B Zimmermann</last_name>
      <phone>+41-44-632-8657</phone>
      <email>michael.zimmermann@hest.ethz.ch</email>
    </contact>
    <investigator>
      <last_name>Maria Andersson</last_name>
      <role>Sub-Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>China</country>
    <country>Switzerland</country>
    <country>United States</country>
  </location_countries>
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  <verification_date>August 2020</verification_date>
  <study_first_submitted>July 21, 2020</study_first_submitted>
  <study_first_submitted_qc>July 27, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 30, 2020</study_first_posted>
  <last_update_submitted>August 9, 2020</last_update_submitted>
  <last_update_submitted_qc>August 9, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">August 11, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Tianjin Medical University</investigator_affiliation>
    <investigator_full_name>Wanqi Zhang</investigator_full_name>
    <investigator_title>professor</investigator_title>
  </responsible_party>
  <keyword>public nutrition</keyword>
  <keyword>nutrition of special population</keyword>
  <keyword>lactating women and infants</keyword>
  <keyword>physiological compensatory mechanism</keyword>
  <keyword>iodine balance study</keyword>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04492657
org study id: NSFC-8191001159
nct id: NCT04492657
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Due to the lack of direct evidence of optimal iodine intake of Chinese children, pregnant and
      lactating women and infants were found during the recent revision of Chinese dietary
      reference intakes (DRIs) of iodine in 2013 by the applicant Pro. Zhang, and no systematical
      research about compensatory mechanism of iodine nutrition in lactating women was found yet.
      Previous study funded by United Nations International Children's Emergency Fund (UNICEF)
      cooperated with the international experts on iodine and key project of national natural
      science foundation of China under the guidance of Pro. Zhang, had obtained the safe intake
      range of iodine from children and pregnant women, more than 10 joint papers were published,
      which laid the foundation of population study and international cooperation.
Studies indicate lactating women and their infants are the most vulnerable population to the
      adverse effects of iodine deficiency and excess, and because of the complexity of the study
      of lactating mothers and infants and the difficulty of sample collection, it is proposed to
      overcome this problem with the help of the advanced dried blood spot technique and iodine
      balance study method from the panel of Iodine Global Network (IGN). Investigators intend to
      recruit 900 late pregnant women in Tianjin, Hebei and Shandong;then establishing a dynamic
      cohort of breastfeeding mother-infant to 6 months after delivery to investigate the
      physiological compensatory mechanism of iodine nutrition in lactating women with the
      combination of animal experiment; On the other hand, 180 exclusively breastfeeding mother and
      infants within postpartum 0-6 months, will be selected to participate the iodine balance
      study.

      Optimized method of iodine balance experiment of infants by both foreign partner and Pro.
      Zhang's team will be adopted to obtain the first iodine balance value of Chinese lactating
      women and infants,providing the direct evidence for the revision of DRIs in lactating women
      and infants, and guide the lactating women proper iodine supplementation to meet the
      requirements of both mothers and infants.
observational model: Other
time perspective: Cross-Sectional
measure: Disposable random urine
time frame: baseline
description: μg/L
measure: Venous blood
time frame: baseline
description: μg/L
measure: Water iodine intake
time frame: baseline
description: μg/day
measure: Salt iodine concentration
time frame: baseline
description: μg/day
measure: Colostrum
time frame: 1 week
description: μg/L
measure: Mother and child urine randomly at one time
time frame: 1 week
description: μg/L
measure: Neonatal heel blood
time frame: 1 week
description: μg/L
measure: Thyroglobulin(TG)
time frame: 1 week
description: ug/L
measure: Thyroid-stimulating hormone
time frame: 1 week
description: mIU/L
measure: Infant disposable random urine
time frame: 4 weeks
description: μg/L
measure: Infant disposable random urine
time frame: 24 weeks
description: μg/L
measure: Infant disposable random urine
time frame: 12 weeks
description: μg/L
measure: 24 h urine
time frame: 4 weeks
description: μg/L
measure: 24 h urine
time frame: 12 weeks
description: μg/L
measure: 24 h urine
time frame: 24 weeks
description: μg/L
measure: Urinary iodine excretion
time frame: 4 weeks
description: μg/day
measure: Urinary iodine excretion
time frame: 12 weeks
description: μg/day
measure: Urinary iodine excretion
time frame: 24 weeks
description: μg/day
measure: Milk output
time frame: 4 weeks
description: μg/day
measure: Milk output
time frame: 12 weeks
description: μg/day
measure: Milk output
time frame: 24 weeks
description: μg/day
measure: Milk iodine excretion
time frame: 4 weeks
description: μg/day
measure: Milk iodine excretion
time frame: 12 weeks
description: μg/day
measure: Milk iodine excretion
time frame: 24 weeks
description: μg/day
measure: Average iodine intake
time frame: 4 weeks
description: μg/day
measure: Average iodine intake
time frame: 12 weeks
description: μg/day
measure: Average iodine intake
time frame: 24 weeks
description: μg/day
measure: Thyroid volume
time frame: 1 week
description: cm³
measure: Thyroid volume
time frame: 4 weeks
description: cm³
measure: Thyroid volume
time frame: 12 weeks
description: cm³
measure: Thyroid volume
time frame: 24 weeks
description: cm³
measure: Thyroid nodule
time frame: 1 week
description: cm³
measure: Thyroid nodule
time frame: 4 weeks
description: cm³
measure: Thyroid nodule
time frame: 12 weeks
description: cm³
measure: Thyroid nodule
time frame: 24 weeks
description: cm³
measure: Dried blood spot(DBS)
time frame: 3 days
description: μg/L
measure: Dried blood spot(DBS)
time frame: 12 weeks
description: μg/L
measure: Diet iodine intake
time frame: 1 week
description: μg/day
measure: Fecal iodine excretion
time frame: 1 week
description: μg/day
intervention type: Other
intervention name: no intervention
description: Natural exposure of iodine.
blood,urine,breast milk
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 1 Day
maximum age: 40 Years
healthy volunteers: Accepts Healthy Volunteers
last name: JianQiang Lai
role: Principal Investigator
affiliation: Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention
last name: XueSong Wang
role: Principal Investigator
affiliation: Shandong Institute of Endemic Disease Control and Prevention
last name: YiFan Duan
role: Principal Investigator
affiliation: Institute of Nutrition and Health, Chinese Center for Disease Control and Prevention
last name: GuiJun Tan
role: Principal Investigator
affiliation: Tianjin Medical University
last name: Wen Chen
role: Principal Investigator
affiliation: Tianjin Medical University
last name: YanTing Chen
role: Principal Investigator
affiliation: Tianjin Medical University
last name: Min Gao
role: Principal Investigator
affiliation: Tianjin Medical University
last name: ZiYun Pan
role: Principal Investigator
affiliation: Tianjin Medical University
last name: Michael B Zimmermann, doctorate
role: Study Chair
affiliation: Swiss federal institute of Technology (ETH)
last name: Elizabeth N Pearce, doctorate
role: Study Chair
affiliation: Boston University School of Medicine; Iodine Global Network (IGN)
last name: Maria Andersson, doctorate
role: Study Chair
affiliation: Swiss federal institute of Technology (ETH); Iodine Global Network (IGN)
last name: WanQi Zhang, doctorate
phone: 022-83336595
email: wqzhang@tmu.edu.cn
last name: ying Ye
phone: 022-83336717
email: yeying@tmu.edu.cn
facility: 
status: Recruiting
contact: 
facility: 
status: Recruiting
contact: 
contact backup: 
facility: 
status: Recruiting
contact: 
contact backup: 
facility: 
status: Recruiting
contact: 
investigator: 
country: China
country: Switzerland
country: United States
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PMID: 26627636
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PMID: 23472655
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responsible party type: Principal Investigator
investigator affiliation: Tianjin Medical University
investigator full name: Wanqi Zhang
investigator title: professor
sharing ipd: No