<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04500574</url>
  </required_header>
  <id_info>
    <org_study_id>2020P001916</org_study_id>
    <secondary_id>2020A000354</secondary_id>
    <nct_id>NCT04500574</nct_id>
  </id_info>
  <brief_title>Latanoprost Eluting Contact Lens for Treating Glaucoma and Ocular Hypertension</brief_title>
  <official_title>Latanoprost Eluting Contact Lens for Treating Glaucoma and Ocular Hypertension</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Massachusetts Eye and Ear Infirmary</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Harvard University</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Massachusetts Eye and Ear Infirmary</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>Yes</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      In this research study, we will assess the safety, tolerability, comfort, and feasibility of&#xD;
      lowering intraocular pressure using a novel Contact Lens Drug Delivery System with&#xD;
      latanoprost. Latanoprost is a well-studied medication and has been used to treat glaucoma for&#xD;
      decades. Currently, latanoprost is FDA-approved to be administered to patients as eye drops,&#xD;
      but using eye drops has challenges (having to remember to take the drop, getting the drop in&#xD;
      the eye). This clinical trial is being done to determine the safety, tolerability, and&#xD;
      effectiveness of using latanoprost to deliver latanoprost in a new way (through a&#xD;
      drug-eluting contact lens).&#xD;
&#xD;
      The study includes two phases. Phase A is intended to assess safety and tolerability and&#xD;
      Phase B to assess safety and effectiveness.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      In Phase A of this study, five subjects will wear the latanoprost-eluting contact lens (L-CL)&#xD;
      for one week. Phase A is designed to assess for safety and tolerability. In Phase B of this&#xD;
      research study, we will compare the L-CL to placebo. Patients will be randomized to one of 2&#xD;
      groups. Subjects in Group 1 will receive the contact lens with latanoprost in it (latanoprost&#xD;
      contact lens, or &quot;L-CL&quot;) and placebo eye drops. Subjects in Group 2 will receive a standard,&#xD;
      commercial contact lens (or &quot;C-CL) that contains no latanoprost but will be given latanoprost&#xD;
      eye drops. The placebo contact lens (C-CL) is highly similar to the latanoprost-eluting&#xD;
      contact lens but contains no latanoprost. The placebo eye drops look just like latanoprost&#xD;
      eye drops but contain no latanoprost.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Recruiting</overall_status>
  <start_date type="Anticipated">April 3, 2023</start_date>
  <completion_date type="Anticipated">December 2023</completion_date>
  <primary_completion_date type="Anticipated">July 2023</primary_completion_date>
  <phase>Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>This is a single-center study to assess the safety and feasibility of delivering latanoprost using the latanoprost contact lens (L-CL) delivery system as a treatment for glaucoma or ocular hypertension. The study has two phases. Phase A is an open-label study with 5 participants; these individuals will wear the L-CL in one eye for one week during which time they will be closely followed with examinations for evaluation of safety. If the L-CL is found to be safe after review of the clinical data by a data and safety monitoring board, phase B will be initiated to assess the safety and effectiveness of delivering latanoprost through the L-CL. This is a double-masked double-dummy study. The L-CL arm will have the drug-eluting latanoprost contact lens (L-CL) and a sham drop, and the latanoprost arm will have a C-CL (no drug) with a nightly 0.005% latanoprost drop.</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Incidence of Treatment-Emergent Adverse Events as assessed by ocular infection, corneal epithelial defects, or cystoid macular edema - Phase A</measure>
    <time_frame>6 - 14 weeks</time_frame>
    <description>Safety assessed by the occurrence of the following adverse events: ocular infection, corneal epithelial defects or signs of corneal toxicity that are not contact lens staining patterns, superficial punctate or vortex, cystoid macular edema</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Incidence of Treatment-Emergent Adverse Events as assessed by ocular infection, corneal epithelial defects, or cystoid macular edema - Phase B</measure>
    <time_frame>6 weeks</time_frame>
    <description>Safety assessed by the occurrence of the following adverse events: ocular infection, corneal epithelial defects or signs of corneal toxicity that are not contact lens staining patterns, superficial punctate or vortex, cystoid macular edema</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Efficacy assessed by changes in intraocular pressure - Phase B</measure>
    <time_frame>6 weeks</time_frame>
    <description>Effectiveness: % change in intraocular pressure (IOP) from baseline (following washout, i.e., on no medications) in each arm ; Difference in mean intraocular pressure comparing the L-CL arm to the topical latanoprost arm; % change in IOP in each arm compared to baseline IOP on topical latanoprost</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Preliminary efficacy - Phase A: % change in IOP from baseline</measure>
    <time_frame>6 - 14 weeks</time_frame>
    <description>Assess by comparing % change in IOP from baseline following washout (i.e., on no medications), % change in IOP from topical latanoprost compared to the L-CL</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Tolerability and comfort: questionnaire</measure>
    <time_frame>6- 14 weeks</time_frame>
    <description>We will assess the tolerability and comfort of the L-CL by using the validated questionnaire Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8). The CLDEQ-8 has as a minimum value a score of 1 and as a maximum value a score of 37. A higher score means a worse outcome.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">31</enrollment>
  <condition>Glaucoma</condition>
  <condition>Ocular Hypertension</condition>
  <arm_group>
    <arm_group_label>Latanoprost contact lens</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>The L-CL arm will have the drug-eluting latanoprost contact lens (L-CL) and a sham drop.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Topical Latanoprost</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>The placebo arm will have a commercial contact lens with no drug with a nightly 0.005% latanoprost drop.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Latanoprost eluting contact lens</intervention_name>
    <description>The latanoprost-contact lens will be worn in one eye for one week.</description>
    <arm_group_label>Latanoprost contact lens</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Topical Latanoprost</intervention_name>
    <description>A commercial contact lens with no drug will be worn in one eye for one week.</description>
    <arm_group_label>Topical Latanoprost</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  18 - 85 years of age willing and able to give informed consent and in the&#xD;
             investigator's judgment able to follow the study protocol&#xD;
&#xD;
          -  Ocular hypertension, primary open-angle glaucoma, pigmentary or pseudoexfoliation&#xD;
             glaucoma, with mild to moderate glaucoma defined as Mean Deviation on Humphrey Visual&#xD;
             Field testing no worse than -10 dB&#xD;
&#xD;
          -  Patients on latanoprost in the study eye with an adequate IOP control with latanoprost&#xD;
             alone&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
        Systemic&#xD;
&#xD;
          -  Use of oral carbonic anhydrase inhibitors&#xD;
&#xD;
          -  Unstable dose of oral medication during the last 30 days that in the opinion of the&#xD;
             Investigator may influence the IOP&#xD;
&#xD;
          -  Unstable dose of oral steroid at the time of enrollment&#xD;
&#xD;
          -  Use of immunosuppressants, immunomodulators, antimetabolites and/or alkylating agents&#xD;
             within six months before screening or anticipated use at any time during the study&#xD;
&#xD;
          -  Known allergy or hypersensitivity to the study medication or its components&#xD;
&#xD;
          -  Female patients who are pregnant, nursing, or planning a pregnancy, or who are of&#xD;
             childbearing potential and not using a reliable means of contraception&#xD;
&#xD;
          -  Participation in an investigational drug or device study within the 30 days before&#xD;
             screening&#xD;
&#xD;
          -  Patient has a condition or is in a situation which, in the Investigator's opinion, may&#xD;
             put the patient at significant risk, may confound the study results, or may interfere&#xD;
             significantly with the patient's participation in the study&#xD;
&#xD;
          -  Any condition (including the inability to read visual acuity charts or language&#xD;
             barrier) which precludes a patient's ability to comply with study requirements&#xD;
             including completion of the study&#xD;
&#xD;
        Study Eye&#xD;
&#xD;
          -  History of complex cataract surgery with vitreous loss&#xD;
&#xD;
          -  History of cystoid macular edema or uveitis&#xD;
&#xD;
          -  Corneal decompensation or edema&#xD;
&#xD;
          -  Corneal thickness &lt;500 or &gt; 600 μm in the study eye by pachymetry&#xD;
&#xD;
          -  Prior treatment-related adverse event or allergy to latanoprost&#xD;
&#xD;
          -  Evidence of macular edema/intraretinal fluid on screening macula optical coherence&#xD;
             tomography (OCT)&#xD;
&#xD;
          -  Any ocular condition in the study eye that in the opinion of the investigator would&#xD;
             prevent the eye from wearing a contact lens (e.g., ectropion, lid abnormality, or&#xD;
             symblepharon)&#xD;
&#xD;
          -  Use of beta-blocker, alpha agonist, rho kinase inhibitor, or carbonic anhydrase&#xD;
             inhibitor drops within 1 month prior to screening; the use of latanoprost must be&#xD;
             stable for at least 4 weeks prior to screening&#xD;
&#xD;
          -  Use of latanoprost for &lt; 4 weeks prior to screening&#xD;
&#xD;
          -  Use of topical steroids&#xD;
&#xD;
          -  Active optic disc or retinal neovascularization in the study eye at screening&#xD;
&#xD;
          -  Presence of rubeosis iridis in the study eye at screening&#xD;
&#xD;
          -  History of herpetic infection in the study eye or adnexa&#xD;
&#xD;
          -  Media opacity in the study eye at screening that precludes clinical and photographic&#xD;
             evaluation (including but not limited to preretinal or vitreous hemorrhage, lens&#xD;
             opacity)&#xD;
&#xD;
          -  Intraocular surgery, including cataract surgery, and/or laser of any type in the study&#xD;
             eye within 30 days prior to screening&#xD;
&#xD;
          -  History of kerato-refractive surgery&#xD;
&#xD;
          -  Any prior filtering surgery, including trabeculectomy, glaucoma drainage device, or&#xD;
             Xen implant&#xD;
&#xD;
          -  Inability to comfortably wear a commercial contact lens (C-CL) that has the same&#xD;
             dimensions as the L-CL during the week-long run-in period&#xD;
&#xD;
        Both Eyes: any active ocular infection (i.e., bacterial, viral, parasitic, or fungal) in&#xD;
        either eye at screening&#xD;
&#xD;
        Non-study Eye: Pinhole score &lt; 19 letters (at least 20/400 Snellen equivalent) in the&#xD;
        non-study eye at the screening visit&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>85 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>David S Friedman, MD, PhD, MPH</last_name>
    <role>Principal Investigator</role>
    <affiliation>Massachusetts Eye and Ear</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>David S Friedman, MD, PhD, MPH</last_name>
    <phone>(617) 573-3202</phone>
    <email>david_friedman@meei.harvard.edu</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Courtney L Ondeck, MD, MPhil</last_name>
    <phone>(617) 573-3202</phone>
    <email>courtney_ondeck@meei.harvard.edu</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Massachusetts Eye and Ear</name>
      <address>
        <city>Boston</city>
        <state>Massachusetts</state>
        <zip>02114</zip>
        <country>United States</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>David Friedman, MD</last_name>
      <phone>617-573-3202</phone>
      <email>David_Friedman@MEEI.HARVARD.EDU</email>
    </contact>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <reference>
    <citation>Ciolino JB, Ross AE, Tulsan R, Watts AC, Wang RF, Zurakowski D, Serle JB, Kohane DS. Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys. Ophthalmology. 2016 Oct;123(10):2085-92. doi: 10.1016/j.ophtha.2016.06.038. Epub 2016 Aug 29.</citation>
    <PMID>27586444</PMID>
  </reference>
  <reference>
    <citation>Ciolino JB, Stefanescu CF, Ross AE, Salvador-Culla B, Cortez P, Ford EM, Wymbs KA, Sprague SL, Mascoop DR, Rudina SS, Trauger SA, Cade F, Kohane DS. In vivo performance of a drug-eluting contact lens to treat glaucoma for a month. Biomaterials. 2014 Jan;35(1):432-9. doi: 10.1016/j.biomaterials.2013.09.032. Epub 2013 Oct 4.</citation>
    <PMID>24094935</PMID>
  </reference>
  <reference>
    <citation>Friedman DS, Wolfs RC, O'Colmain BJ, Klein BE, Taylor HR, West S, Leske MC, Mitchell P, Congdon N, Kempen J; Eye Diseases Prevalence Research Group. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004 Apr;122(4):532-8. doi: 10.1001/archopht.122.4.532. Erratum In: Arch Ophthalmol. 2011 Sep;129(9):1224.</citation>
    <PMID>15078671</PMID>
  </reference>
  <reference>
    <citation>Sleath B, Blalock S, Covert D, Stone JL, Skinner AC, Muir K, Robin AL. The relationship between glaucoma medication adherence, eye drop technique, and visual field defect severity. Ophthalmology. 2011 Dec;118(12):2398-402. doi: 10.1016/j.ophtha.2011.05.013.</citation>
    <PMID>21856009</PMID>
  </reference>
  <verification_date>April 2023</verification_date>
  <study_first_submitted>July 28, 2020</study_first_submitted>
  <study_first_submitted_qc>August 3, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">August 5, 2020</study_first_posted>
  <last_update_submitted>April 4, 2023</last_update_submitted>
  <last_update_submitted_qc>April 4, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">April 6, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Massachusetts Eye and Ear Infirmary</investigator_affiliation>
    <investigator_full_name>David Steven Friedman</investigator_full_name>
    <investigator_title>MD, PhD, MPH, Director Glaucoma Services</investigator_title>
  </responsible_party>
  <keyword>Latanoprost</keyword>
  <keyword>Glaucoma</keyword>
  <keyword>Ocular Hypertension</keyword>
  <keyword>Drug eluting contact lens</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Glaucoma</mesh_term>
    <mesh_term>Ocular Hypertension</mesh_term>
    <mesh_term>Hypertension</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Latanoprost</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
    <ipd_description>There is not a plan to make individual participant data (IPD) available.</ipd_description>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04500574
org study id: 2020P001916
secondary id: 2020A000354
nct id: NCT04500574
lead sponsor: 
collaborator: 
has dmc: Yes
is fda regulated drug: Yes
is fda regulated device: No
In this research study, we will assess the safety, tolerability, comfort, and feasibility of
      lowering intraocular pressure using a novel Contact Lens Drug Delivery System with
      latanoprost. Latanoprost is a well-studied medication and has been used to treat glaucoma for
      decades. Currently, latanoprost is FDA-approved to be administered to patients as eye drops,
      but using eye drops has challenges (having to remember to take the drop, getting the drop in
      the eye). This clinical trial is being done to determine the safety, tolerability, and
      effectiveness of using latanoprost to deliver latanoprost in a new way (through a
      drug-eluting contact lens).

      The study includes two phases. Phase A is intended to assess safety and tolerability and
      Phase B to assess safety and effectiveness.
In Phase A of this study, five subjects will wear the latanoprost-eluting contact lens (L-CL)
      for one week. Phase A is designed to assess for safety and tolerability. In Phase B of this
      research study, we will compare the L-CL to placebo. Patients will be randomized to one of 2
      groups. Subjects in Group 1 will receive the contact lens with latanoprost in it (latanoprost
      contact lens, or "L-CL") and placebo eye drops. Subjects in Group 2 will receive a standard,
      commercial contact lens (or "C-CL) that contains no latanoprost but will be given latanoprost
      eye drops. The placebo contact lens (C-CL) is highly similar to the latanoprost-eluting
      contact lens but contains no latanoprost. The placebo eye drops look just like latanoprost
      eye drops but contain no latanoprost.
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: This is a single-center study to assess the safety and feasibility of delivering latanoprost using the latanoprost contact lens (L-CL) delivery system as a treatment for glaucoma or ocular hypertension. The study has two phases. Phase A is an open-label study with 5 participants; these individuals will wear the L-CL in one eye for one week during which time they will be closely followed with examinations for evaluation of safety. If the L-CL is found to be safe after review of the clinical data by a data and safety monitoring board, phase B will be initiated to assess the safety and effectiveness of delivering latanoprost through the L-CL. This is a double-masked double-dummy study. The L-CL arm will have the drug-eluting latanoprost contact lens (L-CL) and a sham drop, and the latanoprost arm will have a C-CL (no drug) with a nightly 0.005% latanoprost drop.
primary purpose: Treatment
masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
measure: Incidence of Treatment-Emergent Adverse Events as assessed by ocular infection, corneal epithelial defects, or cystoid macular edema - Phase A
time frame: 6 - 14 weeks
description: Safety assessed by the occurrence of the following adverse events: ocular infection, corneal epithelial defects or signs of corneal toxicity that are not contact lens staining patterns, superficial punctate or vortex, cystoid macular edema
measure: Incidence of Treatment-Emergent Adverse Events as assessed by ocular infection, corneal epithelial defects, or cystoid macular edema - Phase B
time frame: 6 weeks
description: Safety assessed by the occurrence of the following adverse events: ocular infection, corneal epithelial defects or signs of corneal toxicity that are not contact lens staining patterns, superficial punctate or vortex, cystoid macular edema
measure: Efficacy assessed by changes in intraocular pressure - Phase B
time frame: 6 weeks
description: Effectiveness: % change in intraocular pressure (IOP) from baseline (following washout, i.e., on no medications) in each arm ; Difference in mean intraocular pressure comparing the L-CL arm to the topical latanoprost arm; % change in IOP in each arm compared to baseline IOP on topical latanoprost
measure: Preliminary efficacy - Phase A: % change in IOP from baseline
time frame: 6 - 14 weeks
description: Assess by comparing % change in IOP from baseline following washout (i.e., on no medications), % change in IOP from topical latanoprost compared to the L-CL
measure: Tolerability and comfort: questionnaire
time frame: 6- 14 weeks
description: We will assess the tolerability and comfort of the L-CL by using the validated questionnaire Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8). The CLDEQ-8 has as a minimum value a score of 1 and as a maximum value a score of 37. A higher score means a worse outcome.
arm group label: Latanoprost contact lens
arm group type: Experimental
description: The L-CL arm will have the drug-eluting latanoprost contact lens (L-CL) and a sham drop.
arm group label: Topical Latanoprost
arm group type: Placebo Comparator
description: The placebo arm will have a commercial contact lens with no drug with a nightly 0.005% latanoprost drop.
intervention type: Drug
intervention name: Latanoprost eluting contact lens
description: The latanoprost-contact lens will be worn in one eye for one week.
arm group label: Latanoprost contact lens
intervention type: Drug
intervention name: Topical Latanoprost
description: A commercial contact lens with no drug will be worn in one eye for one week.
arm group label: Topical Latanoprost
criteria: 
gender: All
minimum age: 18 Years
maximum age: 85 Years
healthy volunteers: No
last name: David S Friedman, MD, PhD, MPH
role: Principal Investigator
affiliation: Massachusetts Eye and Ear
last name: David S Friedman, MD, PhD, MPH
phone: (617) 573-3202
email: david_friedman@meei.harvard.edu
last name: Courtney L Ondeck, MD, MPhil
phone: (617) 573-3202
email: courtney_ondeck@meei.harvard.edu
facility: 
status: Recruiting
contact: 
country: United States
citation: Ciolino JB, Ross AE, Tulsan R, Watts AC, Wang RF, Zurakowski D, Serle JB, Kohane DS. Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys. Ophthalmology. 2016 Oct;123(10):2085-92. doi: 10.1016/j.ophtha.2016.06.038. Epub 2016 Aug 29.
PMID: 27586444
citation: Ciolino JB, Stefanescu CF, Ross AE, Salvador-Culla B, Cortez P, Ford EM, Wymbs KA, Sprague SL, Mascoop DR, Rudina SS, Trauger SA, Cade F, Kohane DS. In vivo performance of a drug-eluting contact lens to treat glaucoma for a month. Biomaterials. 2014 Jan;35(1):432-9. doi: 10.1016/j.biomaterials.2013.09.032. Epub 2013 Oct 4.
PMID: 24094935
citation: Friedman DS, Wolfs RC, O'Colmain BJ, Klein BE, Taylor HR, West S, Leske MC, Mitchell P, Congdon N, Kempen J; Eye Diseases Prevalence Research Group. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004 Apr;122(4):532-8. doi: 10.1001/archopht.122.4.532. Erratum In: Arch Ophthalmol. 2011 Sep;129(9):1224.
PMID: 15078671
citation: Sleath B, Blalock S, Covert D, Stone JL, Skinner AC, Muir K, Robin AL. The relationship between glaucoma medication adherence, eye drop technique, and visual field defect severity. Ophthalmology. 2011 Dec;118(12):2398-402. doi: 10.1016/j.ophtha.2011.05.013.
PMID: 21856009
responsible party type: Principal Investigator
investigator affiliation: Massachusetts Eye and Ear Infirmary
investigator full name: David Steven Friedman
investigator title: MD, PhD, MPH, Director Glaucoma Services
mesh term: Glaucoma
mesh term: Ocular Hypertension
mesh term: Hypertension
mesh term: Latanoprost
sharing ipd: No
ipd description: There is not a plan to make individual participant data (IPD) available.