<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04468802</url>
  </required_header>
  <id_info>
    <org_study_id>KSSEAH--0965</org_study_id>
    <nct_id>NCT04468802</nct_id>
  </id_info>
  <brief_title>Do Childhood Measles and DTaP Vaccination Decrease the Mortality Rate Caused by COVID-19 in OECD Countries?</brief_title>
  <official_title>Do Childhood Measles and DTaP Vaccination Decrease the Mortality Rate Caused by SARS CoV-2 in OECD Countries?</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Kanuni Sultan Suleyman Training and Research Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Kanuni Sultan Suleyman Training and Research Hospital</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Mortality rates caused by SARS CoV-2 differ between countries and this difference might be&#xD;
      explained by several reasons. Childhood vaccination rate is thought to be one of them.&#xD;
      Therefore present study aimed to examine the possible relationship between DTaP (diphtheria,&#xD;
      tetanus, pertussis) and measles vaccination rates of Organization for Economic Co-operation&#xD;
      and Development (OECD) countries and case fatality rate (CFR) caused by SARS CoV-2.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The mortality rates caused by SARS CoV-2 differ between countries and this difference might&#xD;
      be explained by several reasons. Childhood vaccination rate is thought to be one of them.&#xD;
      Therefore present study aimed to examine the possible relationship between DTaP (diphtheria,&#xD;
      tetanus, pertussis) and measles vaccination rates of Organization for Economic Co-operation&#xD;
      and Development (OECD) countries and case fatality rate (CFR) caused by SARS CoV-2.A total of&#xD;
      32 OECD countries, of northern hemisphere, have been included in this study. Statistical&#xD;
      analysis performed according to the CFR data of these countries based on SARS CoV-2. The CFR&#xD;
      data calculated according to the total mortality count of a specific country for the 3-month&#xD;
      period down from the date when first SARS CoV-2 case was observed.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">February 1, 2020</start_date>
  <completion_date type="Actual">July 1, 2020</completion_date>
  <primary_completion_date type="Actual">June 30, 2020</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Only</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Case Fatality Rate</measure>
    <time_frame>4 months</time_frame>
    <description>Mortality rate caused by SARS CoV-2</description>
  </primary_outcome>
  <enrollment type="Actual">32</enrollment>
  <condition>Covid19</condition>
  <condition>Measles Vaccine</condition>
  <condition>Mortality</condition>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Case fatality rate</intervention_name>
    <description>Mortality rate caused by SARS CoV-2</description>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        Children vaccinated in OECD countries in northern hemisphere&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Children vaccinated in OECD countries in northern hemisphere&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Non vaccinated children&#xD;
&#xD;
          -  Southern hemisphere countries&#xD;
&#xD;
          -  non-OECD countries&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>N/A</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>Istanbul Kanuni Sultan Suleyman Training and Research Hospital</name>
      <address>
        <city>Istanbul</city>
        <state>Kucukcekmece</state>
        <zip>34303</zip>
        <country>Turkey</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Turkey</country>
  </location_countries>
  <verification_date>July 2020</verification_date>
  <study_first_submitted>July 9, 2020</study_first_submitted>
  <study_first_submitted_qc>July 9, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">July 13, 2020</study_first_posted>
  <last_update_submitted>July 10, 2020</last_update_submitted>
  <last_update_submitted_qc>July 10, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">July 14, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Kanuni Sultan Suleyman Training and Research Hospital</investigator_affiliation>
    <investigator_full_name>Ramazan Guven</investigator_full_name>
    <investigator_title>Professor</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>COVID-19</mesh_term>
    <mesh_term>Measles</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04468802
org study id: KSSEAH--0965
nct id: NCT04468802
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Mortality rates caused by SARS CoV-2 differ between countries and this difference might be
      explained by several reasons. Childhood vaccination rate is thought to be one of them.
      Therefore present study aimed to examine the possible relationship between DTaP (diphtheria,
      tetanus, pertussis) and measles vaccination rates of Organization for Economic Co-operation
      and Development (OECD) countries and case fatality rate (CFR) caused by SARS CoV-2.
The mortality rates caused by SARS CoV-2 differ between countries and this difference might
      be explained by several reasons. Childhood vaccination rate is thought to be one of them.
      Therefore present study aimed to examine the possible relationship between DTaP (diphtheria,
      tetanus, pertussis) and measles vaccination rates of Organization for Economic Co-operation
      and Development (OECD) countries and case fatality rate (CFR) caused by SARS CoV-2.A total of
      32 OECD countries, of northern hemisphere, have been included in this study. Statistical
      analysis performed according to the CFR data of these countries based on SARS CoV-2. The CFR
      data calculated according to the total mortality count of a specific country for the 3-month
      period down from the date when first SARS CoV-2 case was observed.
observational model: Case-Only
time perspective: Prospective
measure: Case Fatality Rate
time frame: 4 months
description: Mortality rate caused by SARS CoV-2
intervention type: Other
intervention name: Case fatality rate
description: Mortality rate caused by SARS CoV-2
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: N/A
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
facility: 
country: Turkey
responsible party type: Principal Investigator
investigator affiliation: Kanuni Sultan Suleyman Training and Research Hospital
investigator full name: Ramazan Guven
investigator title: Professor
mesh term: COVID-19
mesh term: Measles
sharing ipd: Undecided