<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04438434</url>
  </required_header>
  <id_info>
    <org_study_id>Orto_BMG0703_WIS_June_2020</org_study_id>
    <nct_id>NCT04438434</nct_id>
  </id_info>
  <brief_title>Evaluation of Hydrogen Peroxide and Hyaluronic Acid (BMG0703) in the Healing of Post-extraction Sites</brief_title>
  <official_title>Evaluation of a Filming Formulation of Hydrogen Peroxide and Hyaluronic Acid (BMG0703) in Promoting the Healing of Post-extraction Sites, Compared to Placebo and 0.2% Chlorhexidine. A Randomised Controlled Clinical Trial.</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Milan</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>BMG Pharma</agency>
      <agency_class>Industry</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Milan</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      A clinical study to evaluate the efficacy and safety of a mouthwash containing Hydrogen&#xD;
      Peroxide, Sodium Hyaluronate and Glycine in the healing of post-extraction sites of wisdom&#xD;
      teeth by film forming action.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      57 subjects, with an indication for a third molar extraction, will be enrolled in the study.&#xD;
      Participants selection will take place at the IRCCS &quot;Ca&quot; Granda Ospedale Maggiore Policlinico&#xD;
      of Milan - UOC Surgery Maxillo Facial and Dentistry where the internship activity of the&#xD;
      Degree Course in Dentistry and Dental Prosthetics, Dental Hygiene and the School of&#xD;
      Specialization in Orthodontics of the University of Milan is held.&#xD;
&#xD;
      Subsequently, subjects will be equally divided and randomly assigned into the test or control&#xD;
      groups. Assessment of outcomes will be carried out at a distance of 7 days.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Not yet recruiting</last_known_status>
  <start_date type="Anticipated">June 2020</start_date>
  <completion_date type="Anticipated">July 2020</completion_date>
  <primary_completion_date type="Anticipated">July 2020</primary_completion_date>
  <phase>Phase 3</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Investigator)</masking>
    <masking_description>The products will be packaged in such a way that they are not recognizable either by the operator or by the patient. Each package will be assigned a number that in turn will refer to the type of the product. The association between the number and type of the product will be collected by another operator on the basis of the association carried out by a dedicated software. The operator who will deliver the product will be informed about the type only at the end of the treatment.&#xD;
The data will be collected in pseudonymised form and inserted into a dedicated database in order to carry out the statistical analysis provided.</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Healing Index (Laundry-Turnbull and Howley, modified by Pippi and coll. in 2015)</measure>
    <time_frame>7 days</time_frame>
    <description>For evaluation of healing, the Laundry-Turnbull and Howley index will be used, considering the changes made by Pippi and coll. in 2015. In particular, seven parameters will be evaluated; a value of 1 or 0 will be assigned to each of these parameters; the sum of the values will indicate the degree of healing to be subsequently compared between the different groups.&#xD;
In particular, seven parameters will be assessed, to each of which a value of 1 or 0 will be assigned. The sum of the values will indicate the degree of healing to be compared between the different groups.&#xD;
These seven parameters are: redness of mucosa, granulation tissue, suppuration, swelling, re-epithelialization, bleeding, pain on palpation.&#xD;
Higher score means worse outcome.</description>
  </primary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Anticipated">57</enrollment>
  <condition>Impacted Third Molar Tooth</condition>
  <condition>Healing Surgical Wounds</condition>
  <arm_group>
    <arm_group_label>Hydrogen Peroxide and Hyaluronic acid mouthwash (BMG0703)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>The enrolled subjects will be examined and treated by specialized medical personnel.&#xD;
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.&#xD;
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.&#xD;
The treatment to be evaluated involves mouth rinsing with 10 ml of BMG0703 three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).&#xD;
Patients with allergic reactions or hypersensitivity to the product will be advised to discontinue its use, and seek medical advice.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Chlorhexidine 0.2% mouthwash</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>The enrolled subjects will be examined and treated by specialized medical personnel.&#xD;
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.&#xD;
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.&#xD;
Subjects in this group are to use Chlorhexidine 0.2% mouthwash as an active comparator; 10 ml three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).&#xD;
Patients with allergic reactions or hypersensitivity to Chlorhexidine will be advised to discontinue its use, and seek medical advice.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Placebo product</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>The enrolled subjects will be examined and treated by specialized medical personnel.&#xD;
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.&#xD;
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.&#xD;
Subjects in this group are to use a placebo product, and will be instructed to use 10 ml for mouth rinsing three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).&#xD;
Patients with allergic reactions or hypersensitivity to the product will be advised to discontinue its use, and seek medical advice.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Filming Formulation of Hydrogen Peroxide and Hyaluronic Acid</intervention_name>
    <description>The enrolled subjects will be examined and treated by specialized medical personnel.&#xD;
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.&#xD;
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.&#xD;
The treatment to be evaluated involves mouth rinsing with 10 ml of BMG0703 three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).&#xD;
Patients with allergic reactions or hypersensitivity to the product will be advised to discontinue its use, and seek medical advice.</description>
    <arm_group_label>Hydrogen Peroxide and Hyaluronic acid mouthwash (BMG0703)</arm_group_label>
    <other_name>BMG0703</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Chlorhexidine mouthwash</intervention_name>
    <description>The enrolled subjects will be examined and treated by specialized medical personnel.&#xD;
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.&#xD;
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.&#xD;
Subjects in this group are to use Chlorhexidine 0.2% mouthwash as an active comparator; 10 ml three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).&#xD;
Patients with allergic reactions or hypersensitivity to Chlorhexidine will be advised to discontinue its use, and seek medical advice.</description>
    <arm_group_label>Chlorhexidine 0.2% mouthwash</arm_group_label>
    <other_name>Chlorhexidine 0.2%</other_name>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Placebo product</intervention_name>
    <description>The enrolled subjects will be examined and treated by specialized medical personnel.&#xD;
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.&#xD;
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.&#xD;
Subjects in this group are to use a placebo product, and will be instructed to use 10 ml for mouth rinsing three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).&#xD;
Patients with allergic reactions or hypersensitivity to the product will be advised to discontinue its use, and seek medical advice.</description>
    <arm_group_label>Placebo product</arm_group_label>
    <other_name>Placebo</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Acceptance of informed consent&#xD;
&#xD;
          -  Need to carry out extraction of a third molar in total or partial impaction&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  subjects suffering from HIV&#xD;
&#xD;
          -  subjects suffering from hepatitis&#xD;
&#xD;
          -  serious systemic diseases preventing the use of specific dental therapies&#xD;
&#xD;
          -  acute and/or chronic infectious diseases&#xD;
&#xD;
          -  inability to provide consent&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>12 Years</minimum_age>
    <maximum_age>50 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Giampietro Farronato, Professor</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Milan</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Gianguido Cossellu, Fellow</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Milan</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Chiara Occhipinti, Professor</last_name>
    <phone>+393339155689</phone>
    <email>Chiara.Occhipinti@unimi.it</email>
  </overall_contact>
  <location>
    <facility>
      <name>UOC Maxillofacial Surgery and Odontology, University of Milan</name>
      <address>
        <city>Milan</city>
        <state>Lombardy</state>
        <zip>20122</zip>
        <country>Italy</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Italy</country>
  </location_countries>
  <reference>
    <citation>Rahban SR, Garner WL. Fibroproliferative scars. Clin Plast Surg. 2003 Jan;30(1):77-89. doi: 10.1016/s0094-1298(02)00069-x.</citation>
    <PMID>12636218</PMID>
  </reference>
  <reference>
    <citation>Araujo MG, Silva CO, Misawa M, Sukekava F. Alveolar socket healing: what can we learn? Periodontol 2000. 2015 Jun;68(1):122-34. doi: 10.1111/prd.12082.</citation>
    <PMID>25867983</PMID>
  </reference>
  <reference>
    <citation>Cosyn J, Sabzevar MM. Subgingival chlorhexidine varnish administration as an adjunct to same-day full-mouth root planing. II. Microbiological observations. J Periodontol. 2007 Mar;78(3):438-45. doi: 10.1902/jop.2007.060222.</citation>
    <PMID>17335366</PMID>
  </reference>
  <reference>
    <citation>Lee CT, Zhang S, Leung YY, Li SK, Tsang CC, Chu CH. Patients' satisfaction and prevalence of complications on surgical extraction of third molar. Patient Prefer Adherence. 2015 Feb 10;9:257-63. doi: 10.2147/PPA.S76236. eCollection 2015.</citation>
    <PMID>25709411</PMID>
  </reference>
  <reference>
    <citation>Bouloux GF, Steed MB, Perciaccante VJ. Complications of third molar surgery. Oral Maxillofac Surg Clin North Am. 2007 Feb;19(1):117-28, vii. doi: 10.1016/j.coms.2006.11.013.</citation>
    <PMID>18088870</PMID>
  </reference>
  <verification_date>June 2020</verification_date>
  <study_first_submitted>June 16, 2020</study_first_submitted>
  <study_first_submitted_qc>June 16, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 18, 2020</study_first_posted>
  <last_update_submitted>June 16, 2020</last_update_submitted>
  <last_update_submitted_qc>June 16, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">June 18, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>University of Milan</investigator_affiliation>
    <investigator_full_name>Chiara Occhipinti</investigator_full_name>
    <investigator_title>Professor</investigator_title>
  </responsible_party>
  <keyword>Impacted Third Molar Tooth</keyword>
  <keyword>Surgical wound healing</keyword>
  <keyword>Bleeding</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Tooth, Impacted</mesh_term>
    <mesh_term>Surgical Wound</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Chlorhexidine</mesh_term>
    <mesh_term>Chlorhexidine gluconate</mesh_term>
    <mesh_term>Hydrogen Peroxide</mesh_term>
    <mesh_term>Hyaluronic Acid</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
    <ipd_description>Data available upon request</ipd_description>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04438434
org study id: Orto_BMG0703_WIS_June_2020
nct id: NCT04438434
lead sponsor: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
A clinical study to evaluate the efficacy and safety of a mouthwash containing Hydrogen
      Peroxide, Sodium Hyaluronate and Glycine in the healing of post-extraction sites of wisdom
      teeth by film forming action.
57 subjects, with an indication for a third molar extraction, will be enrolled in the study.
      Participants selection will take place at the IRCCS "Ca" Granda Ospedale Maggiore Policlinico
      of Milan - UOC Surgery Maxillo Facial and Dentistry where the internship activity of the
      Degree Course in Dentistry and Dental Prosthetics, Dental Hygiene and the School of
      Specialization in Orthodontics of the University of Milan is held.

      Subsequently, subjects will be equally divided and randomly assigned into the test or control
      groups. Assessment of outcomes will be carried out at a distance of 7 days.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Double (Participant, Investigator)
masking description: The products will be packaged in such a way that they are not recognizable either by the operator or by the patient. Each package will be assigned a number that in turn will refer to the type of the product. The association between the number and type of the product will be collected by another operator on the basis of the association carried out by a dedicated software. The operator who will deliver the product will be informed about the type only at the end of the treatment.
The data will be collected in pseudonymised form and inserted into a dedicated database in order to carry out the statistical analysis provided.
measure: Healing Index (Laundry-Turnbull and Howley, modified by Pippi and coll. in 2015)
time frame: 7 days
description: For evaluation of healing, the Laundry-Turnbull and Howley index will be used, considering the changes made by Pippi and coll. in 2015. In particular, seven parameters will be evaluated; a value of 1 or 0 will be assigned to each of these parameters; the sum of the values will indicate the degree of healing to be subsequently compared between the different groups.
In particular, seven parameters will be assessed, to each of which a value of 1 or 0 will be assigned. The sum of the values will indicate the degree of healing to be compared between the different groups.
These seven parameters are: redness of mucosa, granulation tissue, suppuration, swelling, re-epithelialization, bleeding, pain on palpation.
Higher score means worse outcome.
arm group label: Hydrogen Peroxide and Hyaluronic acid mouthwash (BMG0703)
arm group type: Experimental
description: The enrolled subjects will be examined and treated by specialized medical personnel.
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.
The treatment to be evaluated involves mouth rinsing with 10 ml of BMG0703 three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).
Patients with allergic reactions or hypersensitivity to the product will be advised to discontinue its use, and seek medical advice.
arm group label: Chlorhexidine 0.2% mouthwash
arm group type: Active Comparator
description: The enrolled subjects will be examined and treated by specialized medical personnel.
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.
Subjects in this group are to use Chlorhexidine 0.2% mouthwash as an active comparator; 10 ml three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).
Patients with allergic reactions or hypersensitivity to Chlorhexidine will be advised to discontinue its use, and seek medical advice.
arm group label: Placebo product
arm group type: Placebo Comparator
description: The enrolled subjects will be examined and treated by specialized medical personnel.
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.
Subjects in this group are to use a placebo product, and will be instructed to use 10 ml for mouth rinsing three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).
Patients with allergic reactions or hypersensitivity to the product will be advised to discontinue its use, and seek medical advice.
intervention type: Drug
intervention name: Filming Formulation of Hydrogen Peroxide and Hyaluronic Acid
description: The enrolled subjects will be examined and treated by specialized medical personnel.
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.
The treatment to be evaluated involves mouth rinsing with 10 ml of BMG0703 three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).
Patients with allergic reactions or hypersensitivity to the product will be advised to discontinue its use, and seek medical advice.
arm group label: Hydrogen Peroxide and Hyaluronic acid mouthwash (BMG0703)
other name: BMG0703
intervention type: Drug
intervention name: Chlorhexidine mouthwash
description: The enrolled subjects will be examined and treated by specialized medical personnel.
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.
Subjects in this group are to use Chlorhexidine 0.2% mouthwash as an active comparator; 10 ml three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).
Patients with allergic reactions or hypersensitivity to Chlorhexidine will be advised to discontinue its use, and seek medical advice.
arm group label: Chlorhexidine 0.2% mouthwash
other name: Chlorhexidine 0.2%
intervention type: Other
intervention name: Placebo product
description: The enrolled subjects will be examined and treated by specialized medical personnel.
The extraction will be carried out by an experienced operator and will follow the standard guidelines for the extraction of impacted teeth. Once the tooth has been removed, a suture with detached stitches using silk thread 3/0 will be applied.
From a pharmacological point of view, the patient will be prescribed antibiotic therapy (Amoxicillin 1g) to be administered twice daily for seven days, analgesic/anti-inflammatory therapy with NSAIDs (e.g. Synflex 550 mg/Brufen 800 mg) are to be used for a maximum of twice daily.
Subjects in this group are to use a placebo product, and will be instructed to use 10 ml for mouth rinsing three times daily, after meals and after normal oral hygiene procedures, for one week (date of the follow-up visit).
Patients with allergic reactions or hypersensitivity to the product will be advised to discontinue its use, and seek medical advice.
arm group label: Placebo product
other name: Placebo
criteria: 
gender: All
minimum age: 12 Years
maximum age: 50 Years
healthy volunteers: No
last name: Giampietro Farronato, Professor
role: Principal Investigator
affiliation: University of Milan
last name: Gianguido Cossellu, Fellow
role: Principal Investigator
affiliation: University of Milan
last name: Chiara Occhipinti, Professor
phone: +393339155689
email: Chiara.Occhipinti@unimi.it
facility: 
country: Italy
citation: Rahban SR, Garner WL. Fibroproliferative scars. Clin Plast Surg. 2003 Jan;30(1):77-89. doi: 10.1016/s0094-1298(02)00069-x.
PMID: 12636218
citation: Araujo MG, Silva CO, Misawa M, Sukekava F. Alveolar socket healing: what can we learn? Periodontol 2000. 2015 Jun;68(1):122-34. doi: 10.1111/prd.12082.
PMID: 25867983
citation: Cosyn J, Sabzevar MM. Subgingival chlorhexidine varnish administration as an adjunct to same-day full-mouth root planing. II. Microbiological observations. J Periodontol. 2007 Mar;78(3):438-45. doi: 10.1902/jop.2007.060222.
PMID: 17335366
citation: Lee CT, Zhang S, Leung YY, Li SK, Tsang CC, Chu CH. Patients' satisfaction and prevalence of complications on surgical extraction of third molar. Patient Prefer Adherence. 2015 Feb 10;9:257-63. doi: 10.2147/PPA.S76236. eCollection 2015.
PMID: 25709411
citation: Bouloux GF, Steed MB, Perciaccante VJ. Complications of third molar surgery. Oral Maxillofac Surg Clin North Am. 2007 Feb;19(1):117-28, vii. doi: 10.1016/j.coms.2006.11.013.
PMID: 18088870
responsible party type: Principal Investigator
investigator affiliation: University of Milan
investigator full name: Chiara Occhipinti
investigator title: Professor
mesh term: Tooth, Impacted
mesh term: Surgical Wound
mesh term: Chlorhexidine
mesh term: Chlorhexidine gluconate
mesh term: Hydrogen Peroxide
mesh term: Hyaluronic Acid
sharing ipd: No
ipd description: Data available upon request