<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04448769</url>
  </required_header>
  <id_info>
    <org_study_id>2020PI128</org_study_id>
    <nct_id>NCT04448769</nct_id>
  </id_info>
  <brief_title>Epidemiological Study of Seroprevalence Against the SARS-CoV-2 Virus (COVID-19)</brief_title>
  <acronym>COVAL-NANCY</acronym>
  <official_title>Epidemiological Study of Seroprevalence Against the SARS-CoV-2 Virus (COVID-19) in the Population of the Grand Nancy Metropolitan Area</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Central Hospital, Nancy, France</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>University of Lorraine</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Métropole du Grand Nancy</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Central Hospital, Nancy, France</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      In order to inform the public decision on the containment strategy and knowledge of the&#xD;
      intensity of the epidemic during post-containment, estimates of the share of the population&#xD;
      infected with the SARS-CoV-2 virus responsible for COVID-19 disease at the territorial level&#xD;
      are needed as soon as possible. The aim of the study is to estimate the prevalence of&#xD;
      positive anti-SARS-CoV-2 serologies by detection of IgT-total antibodies (IgM/IgA/IgG) in the&#xD;
      general population of the Grand Nancy Metropolitan area.&#xD;
&#xD;
      A study of seroprevalence and symptom collection, or absence of symptoms, on a cluster&#xD;
      (household) sample of the Grand Nancy Metropolitan population randomly selected will be&#xD;
      conducted.&#xD;
&#xD;
      The target population consists of all the inhabitants of the Grand Nancy Metropolitan area,&#xD;
      from which a sample is drawn from the electoral lists (households) in a random manner to&#xD;
      ensure representativeness. In order to ultimately include 2000 people in the study&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      In order to inform the public decision on the containment strategy and knowledge of the&#xD;
      intensity of the epidemic during post-containment, estimates of the share of the population&#xD;
      infected with the SARS-CoV-2 virus responsible for COVID-19 disease at the territorial level&#xD;
      are needed as soon as possible. To date, these estimates are based on RT-qPCR tests carried&#xD;
      out on individuals with symptoms of the disease, on people likely to present severe forms of&#xD;
      COVID-19, known as 'vulnerable', or on the number of hospitalizations/deaths related to&#xD;
      COVID-19. In order to refine these estimates, it is crucial to carry out measurements on a&#xD;
      random sample of the population and to take biological samples for serological testing, in&#xD;
      accordance with the recommendations of the HAS and the scientific societies.&#xD;
&#xD;
      Besides, it is important to assess the proportion of persons reporting that they have not&#xD;
      developed symptoms of COVID-19 since the beginning of the epidemic among seropositive&#xD;
      persons.&#xD;
&#xD;
      The aim of the study is to estimate the prevalence of positive anti-SARS-CoV-2 serologies by&#xD;
      detection of IgT-total antibodies (IgM/IgA/IgG) in the general population of the Grand Nancy&#xD;
      Metropolitan area.&#xD;
&#xD;
      A study of seroprevalence and symptom collection, or absence of symptoms, on a cluster&#xD;
      (household) sample of the GNM population randomly selected.&#xD;
&#xD;
      It is a cross-sectional, not experimental study in the sense that it does not alter the&#xD;
      exposure of participants; however, it does require a blood sample, which classifies it as&#xD;
      minimal risk intervention research according to French law. The study is monocentric.&#xD;
&#xD;
      The target population consists of all the inhabitants of the Grand Nancy Metropolitan area,&#xD;
      from which a sample is drawn from the electoral lists (households) in a random manner to&#xD;
      ensure representativeness. In order to ultimately include 2000 people in the study.&#xD;
&#xD;
      Each inhabitant who agrees to participate will have to :&#xD;
&#xD;
        -  sign the consent form after receiving complete information&#xD;
&#xD;
        -  complete a questionnaire exploring sociodemographic (gender, age, professional&#xD;
           activity...), medical (anthropometric measures, health problems, smoking...), potential&#xD;
           contacts with COVID-19 and symptoms.&#xD;
&#xD;
        -  take a blood sample:&#xD;
&#xD;
             -  in one of the identified locations of the GNM after making an appointment with the&#xD;
                dedicated secretariat.&#xD;
&#xD;
             -  at their homes for those vulnerable to Covid-19. The total duration of&#xD;
                participation of a subject will be ½ day (collection of consent + filling in the&#xD;
                questionnaire and blood sampling)&#xD;
&#xD;
      Data are collected from :&#xD;
&#xD;
        -  the electoral lists: surname, first names, gender, address allowing identification of&#xD;
           the IRIS zone&#xD;
&#xD;
        -  self-report questionnaires (adapted to the age : an adult questionnaire, a child&#xD;
           questionnaire completed by the parents and an adolescent questionnaire) :&#xD;
           socio-demographic characteristics of the respondent : age, sex, professional activity,&#xD;
           socio-professional category, level of education ; EPICES questionnaire (adult), FAS&#xD;
           questionnaire (child) ; medical characteristics of the respondent : weight, height,&#xD;
           smoking status, influenza vaccination, health problems, pregnancy; potential contacts&#xD;
           with COVID-19: perception of having been infected by the coronavirus, close relatives&#xD;
           having been infected; potential symptoms: exploration of symptoms felt since&#xD;
           mid-February.&#xD;
&#xD;
        -  serological test results: Anti-SARS-CoV-2 IgT seropositivity&#xD;
&#xD;
      The statistical analysis concerns all participants who respond to the questionnaire (even if&#xD;
      blood sample could not be collected); it does not include any intermediate results and there&#xD;
      is no statistical criterion for stopping the research.&#xD;
&#xD;
      The following analyses will be carried out :&#xD;
&#xD;
        -  Proportions: All proportions (including seroprevalence) will have confidence intervals&#xD;
           calculated with the approximation by the normal distribution when the observed&#xD;
           proportion and the size of the study group allow it, otherwise by the exact calculation&#xD;
           of the binomial distribution.&#xD;
&#xD;
        -  Risk groups: Standardized prevalences for age and sex and their confidence intervals&#xD;
           will be given for each group of each risk factor (smoking status, weight status, level&#xD;
           of insecurity). Significance (p-value) will be calculated by a chi-square test if the&#xD;
           size of the subgroups allows it, a Fisher test otherwise. A relationship will be&#xD;
           significant if p&lt;0.05&#xD;
&#xD;
        -  Analysis of the serology result: The ELISA method allows semi-quantitative detection of&#xD;
           total IgT antibodies. A positive sample will be defined by a ratio ≥ 1.0.&#xD;
&#xD;
        -  Intra-household transmission: The share of infections due to intra-household&#xD;
           transmission will be estimated using a Bayesian model.&#xD;
&#xD;
             -  - Symptom expression groups: In seropositive participants, an exploratory study&#xD;
                will be conducted to determine whether there are typologies of symptom expression .&#xD;
&#xD;
      This type of survey should make it possible to estimate the penetration of the virus in a&#xD;
      very geographically targeted population (GNM area) over a short period of time and to&#xD;
      evaluate the role of households in the transmission of SARS-CoV-2.&#xD;
&#xD;
      This measurement, based on a random sample, could make it possible to consolidate estimates&#xD;
      obtained from molecular biology data (qRT-PCR) or the number of hospitalizations and/or&#xD;
      deaths.&#xD;
&#xD;
      In addition, in vitro neutralization tests will allow an initial assessment of the ability of&#xD;
      the detected antibodies to protect against SARS-CoV-2.&#xD;
&#xD;
      Combined with other similar studies (COVAL Paris, Epicov, ...) it will make it possible to&#xD;
      measure the heterogeneity of virus penetration at the national level and to consolidate&#xD;
      symptom association profiles.&#xD;
&#xD;
      All of the results (detection of cases of infection, particularly those that have not&#xD;
      experienced symptoms, estimation of the number of people protected against a new infection&#xD;
      (neutralisation results)) will in turn feed into mathematical models of the SEIR type&#xD;
      (Susceptible, Exposed, Infected, Recovered).&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">June 26, 2020</start_date>
  <completion_date type="Actual">July 24, 2020</completion_date>
  <primary_completion_date type="Actual">July 24, 2020</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>N/A</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <intervention_model_description>A study of seroprevalence and symptom collection, or absence of symptoms, on a cluster (household) sample of the Grand Nancy Metropolitan population randomly selected.</intervention_model_description>
    <primary_purpose>Screening</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Anti-SARS-CoV-2 IgT (IgM/IgA/IgG) seropositivity</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>Anti-SARS-CoV-2 IgT seropositivity of the individuals tested in the population of the Grand Nancy Metropolitan area</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Proportion of asymptomatic, symptomatic cases among seropositive people</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>To estimate the proportion of occurrence of an episode of clinical symptoms since the beginning of the epidemic among seropositive people using self report questionnaires.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Proportion of asymptomatic cases among seropositive people</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>To estimate the proportion of asymptomatic cases (asymptomatic fraction) by the proportion of seropositive individuals who did not show any sign or symptom of COVID-19 since the beginning of the epidemic in France (mid-February).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Identification of risk groups - Anti-SARS-CoV-2 IgT seropositivity by age, sex and as a function of weight status, smoking status, work activity and social status.</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>To understand susceptibility factors to infection by comparing infected and uninfected persons on the basis of age, sex, weight status, smoking status, occupation and education.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Proportion of seropositive subjects according to the level of social disadvantage measured by the EPICES score</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>Determining the prevalence of seropositive people according to the level of social disadvantage</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Proportion of infected households</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>To estimate the prevalence of infected households</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Anti-SARS-CoV-2 IgT seropositivity in the household</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>To provide knowledge on intra-household dissemination</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Clinical expression patterns of infection by symptom/antibody association</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>To develop symptom association profiles in seropositive subjects</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Serological Response to Infection</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>To study the serum distribution of seropositive people, particularly in each symptom typology group.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Anti-SARS-CoV-2 IgT seropositivity</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>To use the results of the SARS-CoV-2 seroprevalence testing campaign and questionnaires to refine our knowledge of the current and future situation and make better projections with better calibrated mathematical models of SIR infectious diseases.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>• Evaluation of serum neutralisation of persons positive for anti-SARS-CoV-2 antibodies, of the infectivity of viral strains in cell culture: percentage neutralisation compared to a viral strain not exposed to seropositive serum.</measure>
    <time_frame>through study completion, an average of 4 hours</time_frame>
    <description>10. To evaluate the in vitro neutralisation capacity of the viral infectivity of the antibodies detected.</description>
  </secondary_outcome>
  <number_of_arms>1</number_of_arms>
  <enrollment type="Actual">2006</enrollment>
  <condition>Coronavirus Infection</condition>
  <condition>Prevalence</condition>
  <arm_group>
    <arm_group_label>Anti-SARS-CoV-2 IgT seropositivity</arm_group_label>
    <arm_group_type>Other</arm_group_type>
    <description>Analysis of the serology result: The ELISA method allows semi-quantitative detection of total IgT antibodies. A positive sample will be defined by a ratio ≥ 1.0.</description>
  </arm_group>
  <intervention>
    <intervention_type>Biological</intervention_type>
    <intervention_name>Anti-SARS-CoV-2 IgT seropositivity</intervention_name>
    <description>Each inhabitant who agrees to participate will have to :&#xD;
sign the consent form after receiving complete information&#xD;
complete a questionnaire exploring sociodemographic (gender, age, professional activity...), medical (anthropometric measures, health problems, smoking...), potential contacts with COVID-19 and symptoms.&#xD;
take a blood sample for the dermination of anti-SARS-CoV-2 IgT seropositivity of the individuals tested in the population of the Grand Nancy Metropolitan area (GNM).</description>
    <arm_group_label>Anti-SARS-CoV-2 IgT seropositivity</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Person who has received full information about the research organization and signed&#xD;
             informed consent&#xD;
&#xD;
          -  Person residing in the Grand Nancy Metropolitan area&#xD;
&#xD;
          -  Person aged at least 5 years on 1 June 2020 and weighing more than 7 kg&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Children under 5 years of age at the time of collection&#xD;
&#xD;
          -  Person referred to in Articles L1121-8 of the Public Health Code. A person of full age&#xD;
             who is subject to a legal protection measure (guardianship, curatorship, legal&#xD;
             protection).&#xD;
&#xD;
        Adult person unable to give consent&#xD;
&#xD;
        - Persons deprived of their liberty by a judicial or administrative decision, persons under&#xD;
        psychiatric care pursuant to articles L. 3212-1 and L. 3213-1.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>5 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Evelyne Schvoerer</last_name>
    <role>Principal Investigator</role>
    <affiliation>CHRU Nancy</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Chru Nancy</name>
      <address>
        <city>Vandœuvre-lès-Nancy</city>
        <zip>54500</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>France</country>
  </location_countries>
  <verification_date>August 2020</verification_date>
  <study_first_submitted>June 23, 2020</study_first_submitted>
  <study_first_submitted_qc>June 25, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">June 26, 2020</study_first_posted>
  <last_update_submitted>August 18, 2020</last_update_submitted>
  <last_update_submitted_qc>August 18, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">August 19, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Central Hospital, Nancy, France</investigator_affiliation>
    <investigator_full_name>Evelyne Schvoerer</investigator_full_name>
    <investigator_title>Pr</investigator_title>
  </responsible_party>
  <keyword>Epidemiology</keyword>
  <keyword>General population</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Coronavirus Infections</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Yes</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04448769
org study id: 2020PI128
nct id: NCT04448769
lead sponsor: 
collaborator: 
collaborator: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
In order to inform the public decision on the containment strategy and knowledge of the
      intensity of the epidemic during post-containment, estimates of the share of the population
      infected with the SARS-CoV-2 virus responsible for COVID-19 disease at the territorial level
      are needed as soon as possible. The aim of the study is to estimate the prevalence of
      positive anti-SARS-CoV-2 serologies by detection of IgT-total antibodies (IgM/IgA/IgG) in the
      general population of the Grand Nancy Metropolitan area.

      A study of seroprevalence and symptom collection, or absence of symptoms, on a cluster
      (household) sample of the Grand Nancy Metropolitan population randomly selected will be
      conducted.

      The target population consists of all the inhabitants of the Grand Nancy Metropolitan area,
      from which a sample is drawn from the electoral lists (households) in a random manner to
      ensure representativeness. In order to ultimately include 2000 people in the study
In order to inform the public decision on the containment strategy and knowledge of the
      intensity of the epidemic during post-containment, estimates of the share of the population
      infected with the SARS-CoV-2 virus responsible for COVID-19 disease at the territorial level
      are needed as soon as possible. To date, these estimates are based on RT-qPCR tests carried
      out on individuals with symptoms of the disease, on people likely to present severe forms of
      COVID-19, known as 'vulnerable', or on the number of hospitalizations/deaths related to
      COVID-19. In order to refine these estimates, it is crucial to carry out measurements on a
      random sample of the population and to take biological samples for serological testing, in
      accordance with the recommendations of the HAS and the scientific societies.

      Besides, it is important to assess the proportion of persons reporting that they have not
      developed symptoms of COVID-19 since the beginning of the epidemic among seropositive
      persons.

      The aim of the study is to estimate the prevalence of positive anti-SARS-CoV-2 serologies by
      detection of IgT-total antibodies (IgM/IgA/IgG) in the general population of the Grand Nancy
      Metropolitan area.

      A study of seroprevalence and symptom collection, or absence of symptoms, on a cluster
      (household) sample of the GNM population randomly selected.

      It is a cross-sectional, not experimental study in the sense that it does not alter the
      exposure of participants; however, it does require a blood sample, which classifies it as
      minimal risk intervention research according to French law. The study is monocentric.

      The target population consists of all the inhabitants of the Grand Nancy Metropolitan area,
      from which a sample is drawn from the electoral lists (households) in a random manner to
      ensure representativeness. In order to ultimately include 2000 people in the study.

      Each inhabitant who agrees to participate will have to :

        -  sign the consent form after receiving complete information

        -  complete a questionnaire exploring sociodemographic (gender, age, professional
           activity...), medical (anthropometric measures, health problems, smoking...), potential
           contacts with COVID-19 and symptoms.

        -  take a blood sample:

             -  in one of the identified locations of the GNM after making an appointment with the
                dedicated secretariat.

             -  at their homes for those vulnerable to Covid-19. The total duration of
                participation of a subject will be ½ day (collection of consent + filling in the
                questionnaire and blood sampling)

      Data are collected from :

        -  the electoral lists: surname, first names, gender, address allowing identification of
           the IRIS zone

        -  self-report questionnaires (adapted to the age : an adult questionnaire, a child
           questionnaire completed by the parents and an adolescent questionnaire) :
           socio-demographic characteristics of the respondent : age, sex, professional activity,
           socio-professional category, level of education ; EPICES questionnaire (adult), FAS
           questionnaire (child) ; medical characteristics of the respondent : weight, height,
           smoking status, influenza vaccination, health problems, pregnancy; potential contacts
           with COVID-19: perception of having been infected by the coronavirus, close relatives
           having been infected; potential symptoms: exploration of symptoms felt since
           mid-February.

        -  serological test results: Anti-SARS-CoV-2 IgT seropositivity

      The statistical analysis concerns all participants who respond to the questionnaire (even if
      blood sample could not be collected); it does not include any intermediate results and there
      is no statistical criterion for stopping the research.

      The following analyses will be carried out :

        -  Proportions: All proportions (including seroprevalence) will have confidence intervals
           calculated with the approximation by the normal distribution when the observed
           proportion and the size of the study group allow it, otherwise by the exact calculation
           of the binomial distribution.

        -  Risk groups: Standardized prevalences for age and sex and their confidence intervals
           will be given for each group of each risk factor (smoking status, weight status, level
           of insecurity). Significance (p-value) will be calculated by a chi-square test if the
           size of the subgroups allows it, a Fisher test otherwise. A relationship will be
           significant if p<0.05

        -  Analysis of the serology result: The ELISA method allows semi-quantitative detection of
           total IgT antibodies. A positive sample will be defined by a ratio ≥ 1.0.

        -  Intra-household transmission: The share of infections due to intra-household
           transmission will be estimated using a Bayesian model.

             -  - Symptom expression groups: In seropositive participants, an exploratory study
                will be conducted to determine whether there are typologies of symptom expression .

      This type of survey should make it possible to estimate the penetration of the virus in a
      very geographically targeted population (GNM area) over a short period of time and to
      evaluate the role of households in the transmission of SARS-CoV-2.

      This measurement, based on a random sample, could make it possible to consolidate estimates
      obtained from molecular biology data (qRT-PCR) or the number of hospitalizations and/or
      deaths.

      In addition, in vitro neutralization tests will allow an initial assessment of the ability of
      the detected antibodies to protect against SARS-CoV-2.

      Combined with other similar studies (COVAL Paris, Epicov, ...) it will make it possible to
      measure the heterogeneity of virus penetration at the national level and to consolidate
      symptom association profiles.

      All of the results (detection of cases of infection, particularly those that have not
      experienced symptoms, estimation of the number of people protected against a new infection
      (neutralisation results)) will in turn feed into mathematical models of the SEIR type
      (Susceptible, Exposed, Infected, Recovered).
allocation: N/A
intervention model: Single Group Assignment
intervention model description: A study of seroprevalence and symptom collection, or absence of symptoms, on a cluster (household) sample of the Grand Nancy Metropolitan population randomly selected.
primary purpose: Screening
masking: None (Open Label)
measure: Anti-SARS-CoV-2 IgT (IgM/IgA/IgG) seropositivity
time frame: through study completion, an average of 4 hours
description: Anti-SARS-CoV-2 IgT seropositivity of the individuals tested in the population of the Grand Nancy Metropolitan area
measure: Proportion of asymptomatic, symptomatic cases among seropositive people
time frame: through study completion, an average of 4 hours
description: To estimate the proportion of occurrence of an episode of clinical symptoms since the beginning of the epidemic among seropositive people using self report questionnaires.
measure: Proportion of asymptomatic cases among seropositive people
time frame: through study completion, an average of 4 hours
description: To estimate the proportion of asymptomatic cases (asymptomatic fraction) by the proportion of seropositive individuals who did not show any sign or symptom of COVID-19 since the beginning of the epidemic in France (mid-February).
measure: Identification of risk groups - Anti-SARS-CoV-2 IgT seropositivity by age, sex and as a function of weight status, smoking status, work activity and social status.
time frame: through study completion, an average of 4 hours
description: To understand susceptibility factors to infection by comparing infected and uninfected persons on the basis of age, sex, weight status, smoking status, occupation and education.
measure: Proportion of seropositive subjects according to the level of social disadvantage measured by the EPICES score
time frame: through study completion, an average of 4 hours
description: Determining the prevalence of seropositive people according to the level of social disadvantage
measure: Proportion of infected households
time frame: through study completion, an average of 4 hours
description: To estimate the prevalence of infected households
measure: Anti-SARS-CoV-2 IgT seropositivity in the household
time frame: through study completion, an average of 4 hours
description: To provide knowledge on intra-household dissemination
measure: Clinical expression patterns of infection by symptom/antibody association
time frame: through study completion, an average of 4 hours
description: To develop symptom association profiles in seropositive subjects
measure: Serological Response to Infection
time frame: through study completion, an average of 4 hours
description: To study the serum distribution of seropositive people, particularly in each symptom typology group.
measure: Anti-SARS-CoV-2 IgT seropositivity
time frame: through study completion, an average of 4 hours
description: To use the results of the SARS-CoV-2 seroprevalence testing campaign and questionnaires to refine our knowledge of the current and future situation and make better projections with better calibrated mathematical models of SIR infectious diseases.
measure: • Evaluation of serum neutralisation of persons positive for anti-SARS-CoV-2 antibodies, of the infectivity of viral strains in cell culture: percentage neutralisation compared to a viral strain not exposed to seropositive serum.
time frame: through study completion, an average of 4 hours
description: 10. To evaluate the in vitro neutralisation capacity of the viral infectivity of the antibodies detected.
arm group label: Anti-SARS-CoV-2 IgT seropositivity
arm group type: Other
description: Analysis of the serology result: The ELISA method allows semi-quantitative detection of total IgT antibodies. A positive sample will be defined by a ratio ≥ 1.0.
intervention type: Biological
intervention name: Anti-SARS-CoV-2 IgT seropositivity
description: Each inhabitant who agrees to participate will have to :
sign the consent form after receiving complete information
complete a questionnaire exploring sociodemographic (gender, age, professional activity...), medical (anthropometric measures, health problems, smoking...), potential contacts with COVID-19 and symptoms.
take a blood sample for the dermination of anti-SARS-CoV-2 IgT seropositivity of the individuals tested in the population of the Grand Nancy Metropolitan area (GNM).
arm group label: Anti-SARS-CoV-2 IgT seropositivity
criteria: 
gender: All
minimum age: 5 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
last name: Evelyne Schvoerer
role: Principal Investigator
affiliation: CHRU Nancy
facility: 
country: France
responsible party type: Principal Investigator
investigator affiliation: Central Hospital, Nancy, France
investigator full name: Evelyne Schvoerer
investigator title: Pr
mesh term: Coronavirus Infections
sharing ipd: Yes