<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT04401397</url>
  </required_header>
  <id_info>
    <org_study_id>PapageorgiouGH</org_study_id>
    <nct_id>NCT04401397</nct_id>
  </id_info>
  <brief_title>Effect of Early Mobilization on Length of Stay, Recovery and Readmission Rate of Patients After CABG or AVR/MVR Surgery</brief_title>
  <official_title>The Effect of Inpatient Intensive Early Mobilisation Intervention on Length of Hospital Stay, Medical and Functional Recovery and Readmission Rate of Patients After CABG or AVR/MVR: A Randomized Single Blind Controlled Clinical Trial.</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Dimitris Chatzitheodorou</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>University of Macedonia, Thessaloniki, Greece</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Papageorgiou General Hospital</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The present study will investigate the volume and extent of the expected physiological&#xD;
      effects of &quot;early mobilization&quot; on the prevention of the clinical illness' detrimental&#xD;
      sequelae and on the functional recovery promotion of CABG, AVR and MVR patients.&#xD;
      Consequently, it will investigate if the improved health outcomes may limit the number and&#xD;
      intensity of complications and thus if it may speed up hospital discharge.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Although the effects of &quot;early mobilization&quot; have been studied mainly in the intensive care&#xD;
      unit setting, the findings could be applied to the surgical units' patients too, since they&#xD;
      share common physiological and clinical characteristics. In the literature the effectiveness&#xD;
      of &quot;early mobilization&quot; in the length of hospital stay and recovery of the patients operated&#xD;
      for coronary artery bypass graft and heart valve replacement in the cardiac surgery setting,&#xD;
      is unknown.&#xD;
&#xD;
      The term &quot;early mobilization&quot; is not restricted to a time factor procedure but contains the&#xD;
      provision of a customized dynamic set of physical therapy techniques which in studies are&#xD;
      variably determined in terms of duration, intensity, frequency and content.&#xD;
&#xD;
      The aim of the study is to determine the clinical effectiveness of the intensive early&#xD;
      mobilization physical therapy intervention compared with standard care of physical therapy in&#xD;
      the cardio-thoracic surgery clinic of Papageorgiou General Hospital of Thessaloniki.&#xD;
&#xD;
      The present study will investigate the volume and extend of the expected physiological&#xD;
      effects of &quot;early mobilization&quot; on the prevention of the clinical illness' detrimental&#xD;
      sequelae and on the functional recovery promotion, hospital mortality and readmission rate of&#xD;
      CABG, AVR and MVR patients. Consequently, it will investigate if the improved health outcomes&#xD;
      may limit the number and intensity of complications and thus may speed up hospital discharge.&#xD;
      In the first group of the experimental design, patients will be treated with an intensive&#xD;
      early mobilization protocol and the patients of the second group will receive a standard care&#xD;
      physical therapy treatment. Controlling for the detailed baseline characteristics that will&#xD;
      be assessed during medical history at admission, potential bias will be limited from&#xD;
      unmeasured confounders of the study.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">June 3, 2020</start_date>
  <completion_date type="Actual">December 23, 2020</completion_date>
  <primary_completion_date type="Actual">December 10, 2020</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Factorial Assignment</intervention_model>
    <intervention_model_description>Prospective randomized controlled double-blind 2-group experimental design.</intervention_model_description>
    <primary_purpose>Supportive Care</primary_purpose>
    <masking>Double (Participant, Outcomes Assessor)</masking>
    <masking_description>Patients and outcomes assessor will be blinded to the protocol each patient will be treated with. Both intervention and standard care protocols will be implemented by a third party.</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Length of postoperative hospital stay</measure>
    <time_frame>Up to 6 weeks</time_frame>
    <description>The number of postoperative days that the patients stay in the ward after their surgery procedure and ICU discharge.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Readmission rate</measure>
    <time_frame>Up to 6 weeks</time_frame>
    <description>The number of discharged patients that will be readmitted in the hospital for a condition of their underlying disease in a 30 days period after surgery.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Number of complications</measure>
    <time_frame>Up to 6 weeks</time_frame>
    <description>The total number of medical events the patients will develop during their postoperative stay in the ward.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Severity of complications</measure>
    <time_frame>Up to 6 weeks</time_frame>
    <description>Classification of the complications as &quot;minor&quot; or &quot;major&quot; according to the physicians' expert opinion based on published clinical standards.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Time to regain hemodynamic stability</measure>
    <time_frame>Up to 6 weeks</time_frame>
    <description>The time in days that is required for the patients to be without inotrope or vasodilator drugs and remain normal and stable in arterial blood pressure, heart rate and blood gas rates.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Two-minute walk test</measure>
    <time_frame>Up to 6 weeks</time_frame>
    <description>The distance in meters that a patient can walk under the specific test conditions, at the day of discharge.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Functional recovery</measure>
    <time_frame>Up to 6 weeks</time_frame>
    <description>The time in days that is required for the patients to be autonomous in accessing and using the toilet in their ward.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>High cost medical procedures</measure>
    <time_frame>Up to 6 weeks</time_frame>
    <description>The number of high cost medical procedures the patients will undergo during their postoperative stay in the ward.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Hospital mortality</measure>
    <time_frame>Up to 6 weeks</time_frame>
    <description>The number of postsurgical hospital deaths.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">40</enrollment>
  <condition>Coronary Artery Disease</condition>
  <condition>Aortic Valve Disease</condition>
  <condition>Mitral Valve Disease</condition>
  <arm_group>
    <arm_group_label>Early mobilization group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Immediately after ICU extubation, enrolled patients will receive an intensive 30-45 minutes, implemented twice a day early mobilization protocol containing psychological empowerment, detailed informative education of patients and close relatives, close monitoring of the recovery course, frequent parameter protocol configuration, high intensity active progressive pulmonary and musculoskeletal exercises and mobility techniques, close monitoring for early identification and measures for prevention and treatment of complications.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Standard care group</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Enrolled patients will receive the standard hospital mobilization protocol after their admission to the ward, containing standardized basic pulmonary and mobilization techniques of 15 minutes, once a day.</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Intensive early mobilization techniques</intervention_name>
    <description>Pulmonary techniques: lung mechanics and breathing pattern restoration, mucus clearance techniques, breathing control and cough techniques.&#xD;
Musculoskeletal techniques: strengthening and functional exercises, active assistive moving techniques.</description>
    <arm_group_label>Early mobilization group</arm_group_label>
    <arm_group_label>Standard care group</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Elective CABG or AVR or MVR surgery&#xD;
&#xD;
          -  No previous CABG or valve surgery&#xD;
&#xD;
          -  Isolated / multivessel CABG&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Current neurological disorders&#xD;
&#xD;
          -  Previous cerebral vascular accident with residual neurological deficit significant&#xD;
             enough to limit exercise&#xD;
&#xD;
          -  Significant limiting comorbidities that would prevent full participation&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>Papageorgiou General Hospital</name>
      <address>
        <city>Thessaloníki</city>
        <state>Pavlou Mela Municipality</state>
        <zip>56403</zip>
        <country>Greece</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Greece</country>
  </location_countries>
  <reference>
    <citation>Chiarici A, Andrenelli E, Serpilli O, Andreolini M, Tedesco S, Pomponio G, Gallo MM, Martini C, Papa R, Coccia M, Ceravolo MG. An Early Tailored Approach Is the Key to Effective Rehabilitation in the Intensive Care Unit. Arch Phys Med Rehabil. 2019 Aug;100(8):1506-1514. doi: 10.1016/j.apmr.2019.01.015. Epub 2019 Feb 21.</citation>
    <PMID>30796918</PMID>
  </reference>
  <reference>
    <citation>Corcoran JR, Herbsman JM, Bushnik T, Van Lew S, Stolfi A, Parkin K, McKenzie A, Hall GW, Joseph W, Whiteson J, Flanagan SR. Early Rehabilitation in the Medical and Surgical Intensive Care Units for Patients With and Without Mechanical Ventilation: An Interprofessional Performance Improvement Project. PM R. 2017 Feb;9(2):113-119. doi: 10.1016/j.pmrj.2016.06.015. Epub 2016 Jun 23.</citation>
    <PMID>27346093</PMID>
  </reference>
  <reference>
    <citation>Lord RK, Mayhew CR, Korupolu R, Mantheiy EC, Friedman MA, Palmer JB, Needham DM. ICU early physical rehabilitation programs: financial modeling of cost savings. Crit Care Med. 2013 Mar;41(3):717-24. doi: 10.1097/CCM.0b013e3182711de2.</citation>
    <PMID>23318489</PMID>
  </reference>
  <reference>
    <citation>Tsuboi N, Hiratsuka M, Kaneko S, Nishimura N, Nakagawa S, Kasahara M, Kamikubo T. Benefits of Early Mobilization After Pediatric Liver Transplantation. Pediatr Crit Care Med. 2019 Feb;20(2):e91-e97. doi: 10.1097/PCC.0000000000001815.</citation>
    <PMID>30489487</PMID>
  </reference>
  <reference>
    <citation>van Willigen Z, Collings N, Richardson D, Cusack R. Quality improvement: The delivery of true early mobilisation in an intensive care unit. BMJ Qual Improv Rep. 2016 Dec 30;5(1):u211734.w4726. doi: 10.1136/bmjquality.u211734.w4726. eCollection 2016.</citation>
    <PMID>28090326</PMID>
  </reference>
  <reference>
    <citation>Brummel NE, Girard TD, Ely EW, Pandharipande PP, Morandi A, Hughes CG, Graves AJ, Shintani A, Murphy E, Work B, Pun BT, Boehm L, Gill TM, Dittus RS, Jackson JC. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med. 2014 Mar;40(3):370-9. doi: 10.1007/s00134-013-3136-0. Epub 2013 Nov 21.</citation>
    <PMID>24257969</PMID>
  </reference>
  <reference>
    <citation>Li Z, Peng X, Zhu B, Zhang Y, Xi X. Active mobilization for mechanically ventilated patients: a systematic review. Arch Phys Med Rehabil. 2013 Mar;94(3):551-61. doi: 10.1016/j.apmr.2012.10.023. Epub 2012 Nov 2.</citation>
    <PMID>23127305</PMID>
  </reference>
  <reference>
    <citation>Parker A, Sricharoenchai T, Needham DM. Early Rehabilitation in the Intensive Care Unit: Preventing Physical and Mental Health Impairments. Curr Phys Med Rehabil Rep. 2013 Dec;1(4):307-314. doi: 10.1007/s40141-013-0027-9.</citation>
    <PMID>24436844</PMID>
  </reference>
  <reference>
    <citation>Adler J, Malone D. Early mobilization in the intensive care unit: a systematic review. Cardiopulm Phys Ther J. 2012 Mar;23(1):5-13.</citation>
    <PMID>22807649</PMID>
  </reference>
  <reference>
    <citation>Mendez-Tellez PA, Nusr R, Feldman D, Needham DM. Early Physical Rehabilitation in the ICU: A Review for the Neurohospitalist. Neurohospitalist. 2012 Jul;2(3):96-105. doi: 10.1177/1941874412447631.</citation>
    <PMID>23983871</PMID>
  </reference>
  <reference>
    <citation>Morris PE, Griffin L, Berry M, Thompson C, Hite RD, Winkelman C, Hopkins RO, Ross A, Dixon L, Leach S, Haponik E. Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci. 2011 May;341(5):373-7. doi: 10.1097/MAJ.0b013e31820ab4f6.</citation>
    <PMID>21358312</PMID>
  </reference>
  <reference>
    <citation>Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, Brower RG, Fan E. Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil. 2010 Apr;91(4):536-42. doi: 10.1016/j.apmr.2010.01.002.</citation>
    <PMID>20382284</PMID>
  </reference>
  <reference>
    <citation>Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009 May 30;373(9678):1874-82. doi: 10.1016/S0140-6736(09)60658-9. Epub 2009 May 14.</citation>
    <PMID>19446324</PMID>
  </reference>
  <reference>
    <citation>Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, Ross A, Anderson L, Baker S, Sanchez M, Penley L, Howard A, Dixon L, Leach S, Small R, Hite RD, Haponik E. Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med. 2008 Aug;36(8):2238-43. doi: 10.1097/CCM.0b013e318180b90e.</citation>
    <PMID>18596631</PMID>
  </reference>
  <reference>
    <citation>Hopkins RO, Spuhler VJ, Thomsen GE. Transforming ICU culture to facilitate early mobility. Crit Care Clin. 2007 Jan;23(1):81-96. doi: 10.1016/j.ccc.2006.11.004.</citation>
    <PMID>17307118</PMID>
  </reference>
  <reference>
    <citation>Bailey P, Thomsen GE, Spuhler VJ, Blair R, Jewkes J, Bezdjian L, Veale K, Rodriquez L, Hopkins RO. Early activity is feasible and safe in respiratory failure patients. Crit Care Med. 2007 Jan;35(1):139-45. doi: 10.1097/01.CCM.0000251130.69568.87.</citation>
    <PMID>17133183</PMID>
  </reference>
  <reference>
    <citation>Gosselink R, Bott J, Johnson M, Dean E, Nava S, Norrenberg M, Schonhofer B, Stiller K, van de Leur H, Vincent JL. Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for Critically Ill Patients. Intensive Care Med. 2008 Jul;34(7):1188-99. doi: 10.1007/s00134-008-1026-7. Epub 2008 Feb 19.</citation>
    <PMID>18283429</PMID>
  </reference>
  <verification_date>January 2021</verification_date>
  <study_first_submitted>May 15, 2020</study_first_submitted>
  <study_first_submitted_qc>May 20, 2020</study_first_submitted_qc>
  <study_first_posted type="Actual">May 26, 2020</study_first_posted>
  <last_update_submitted>January 3, 2021</last_update_submitted>
  <last_update_submitted_qc>January 3, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">January 5, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>Papageorgiou General Hospital</investigator_affiliation>
    <investigator_full_name>Dimitris Chatzitheodorou</investigator_full_name>
    <investigator_title>Principal Investigator, Senior Physical Therapist</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Coronary Artery Disease</mesh_term>
    <mesh_term>Aortic Valve Disease</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <pending_results>
    <submitted>December 21, 2021</submitted>
    <returned>March 10, 2022</returned>
  </pending_results>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT04401397
org study id: PapageorgiouGH
nct id: NCT04401397
lead sponsor: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
The present study will investigate the volume and extent of the expected physiological
      effects of "early mobilization" on the prevention of the clinical illness' detrimental
      sequelae and on the functional recovery promotion of CABG, AVR and MVR patients.
      Consequently, it will investigate if the improved health outcomes may limit the number and
      intensity of complications and thus if it may speed up hospital discharge.
Although the effects of "early mobilization" have been studied mainly in the intensive care
      unit setting, the findings could be applied to the surgical units' patients too, since they
      share common physiological and clinical characteristics. In the literature the effectiveness
      of "early mobilization" in the length of hospital stay and recovery of the patients operated
      for coronary artery bypass graft and heart valve replacement in the cardiac surgery setting,
      is unknown.

      The term "early mobilization" is not restricted to a time factor procedure but contains the
      provision of a customized dynamic set of physical therapy techniques which in studies are
      variably determined in terms of duration, intensity, frequency and content.

      The aim of the study is to determine the clinical effectiveness of the intensive early
      mobilization physical therapy intervention compared with standard care of physical therapy in
      the cardio-thoracic surgery clinic of Papageorgiou General Hospital of Thessaloniki.

      The present study will investigate the volume and extend of the expected physiological
      effects of "early mobilization" on the prevention of the clinical illness' detrimental
      sequelae and on the functional recovery promotion, hospital mortality and readmission rate of
      CABG, AVR and MVR patients. Consequently, it will investigate if the improved health outcomes
      may limit the number and intensity of complications and thus may speed up hospital discharge.
      In the first group of the experimental design, patients will be treated with an intensive
      early mobilization protocol and the patients of the second group will receive a standard care
      physical therapy treatment. Controlling for the detailed baseline characteristics that will
      be assessed during medical history at admission, potential bias will be limited from
      unmeasured confounders of the study.
allocation: Randomized
intervention model: Factorial Assignment
intervention model description: Prospective randomized controlled double-blind 2-group experimental design.
primary purpose: Supportive Care
masking: Double (Participant, Outcomes Assessor)
masking description: Patients and outcomes assessor will be blinded to the protocol each patient will be treated with. Both intervention and standard care protocols will be implemented by a third party.
measure: Length of postoperative hospital stay
time frame: Up to 6 weeks
description: The number of postoperative days that the patients stay in the ward after their surgery procedure and ICU discharge.
measure: Readmission rate
time frame: Up to 6 weeks
description: The number of discharged patients that will be readmitted in the hospital for a condition of their underlying disease in a 30 days period after surgery.
measure: Number of complications
time frame: Up to 6 weeks
description: The total number of medical events the patients will develop during their postoperative stay in the ward.
measure: Severity of complications
time frame: Up to 6 weeks
description: Classification of the complications as "minor" or "major" according to the physicians' expert opinion based on published clinical standards.
measure: Time to regain hemodynamic stability
time frame: Up to 6 weeks
description: The time in days that is required for the patients to be without inotrope or vasodilator drugs and remain normal and stable in arterial blood pressure, heart rate and blood gas rates.
measure: Two-minute walk test
time frame: Up to 6 weeks
description: The distance in meters that a patient can walk under the specific test conditions, at the day of discharge.
measure: Functional recovery
time frame: Up to 6 weeks
description: The time in days that is required for the patients to be autonomous in accessing and using the toilet in their ward.
measure: High cost medical procedures
time frame: Up to 6 weeks
description: The number of high cost medical procedures the patients will undergo during their postoperative stay in the ward.
measure: Hospital mortality
time frame: Up to 6 weeks
description: The number of postsurgical hospital deaths.
arm group label: Early mobilization group
arm group type: Experimental
description: Immediately after ICU extubation, enrolled patients will receive an intensive 30-45 minutes, implemented twice a day early mobilization protocol containing psychological empowerment, detailed informative education of patients and close relatives, close monitoring of the recovery course, frequent parameter protocol configuration, high intensity active progressive pulmonary and musculoskeletal exercises and mobility techniques, close monitoring for early identification and measures for prevention and treatment of complications.
arm group label: Standard care group
arm group type: Active Comparator
description: Enrolled patients will receive the standard hospital mobilization protocol after their admission to the ward, containing standardized basic pulmonary and mobilization techniques of 15 minutes, once a day.
intervention type: Procedure
intervention name: Intensive early mobilization techniques
description: Pulmonary techniques: lung mechanics and breathing pattern restoration, mucus clearance techniques, breathing control and cough techniques.
Musculoskeletal techniques: strengthening and functional exercises, active assistive moving techniques.
arm group label: Early mobilization group
arm group label: Standard care group
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
facility: 
country: Greece
citation: Chiarici A, Andrenelli E, Serpilli O, Andreolini M, Tedesco S, Pomponio G, Gallo MM, Martini C, Papa R, Coccia M, Ceravolo MG. An Early Tailored Approach Is the Key to Effective Rehabilitation in the Intensive Care Unit. Arch Phys Med Rehabil. 2019 Aug;100(8):1506-1514. doi: 10.1016/j.apmr.2019.01.015. Epub 2019 Feb 21.
PMID: 30796918
citation: Corcoran JR, Herbsman JM, Bushnik T, Van Lew S, Stolfi A, Parkin K, McKenzie A, Hall GW, Joseph W, Whiteson J, Flanagan SR. Early Rehabilitation in the Medical and Surgical Intensive Care Units for Patients With and Without Mechanical Ventilation: An Interprofessional Performance Improvement Project. PM R. 2017 Feb;9(2):113-119. doi: 10.1016/j.pmrj.2016.06.015. Epub 2016 Jun 23.
PMID: 27346093
citation: Lord RK, Mayhew CR, Korupolu R, Mantheiy EC, Friedman MA, Palmer JB, Needham DM. ICU early physical rehabilitation programs: financial modeling of cost savings. Crit Care Med. 2013 Mar;41(3):717-24. doi: 10.1097/CCM.0b013e3182711de2.
PMID: 23318489
citation: Tsuboi N, Hiratsuka M, Kaneko S, Nishimura N, Nakagawa S, Kasahara M, Kamikubo T. Benefits of Early Mobilization After Pediatric Liver Transplantation. Pediatr Crit Care Med. 2019 Feb;20(2):e91-e97. doi: 10.1097/PCC.0000000000001815.
PMID: 30489487
citation: van Willigen Z, Collings N, Richardson D, Cusack R. Quality improvement: The delivery of true early mobilisation in an intensive care unit. BMJ Qual Improv Rep. 2016 Dec 30;5(1):u211734.w4726. doi: 10.1136/bmjquality.u211734.w4726. eCollection 2016.
PMID: 28090326
citation: Brummel NE, Girard TD, Ely EW, Pandharipande PP, Morandi A, Hughes CG, Graves AJ, Shintani A, Murphy E, Work B, Pun BT, Boehm L, Gill TM, Dittus RS, Jackson JC. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med. 2014 Mar;40(3):370-9. doi: 10.1007/s00134-013-3136-0. Epub 2013 Nov 21.
PMID: 24257969
citation: Li Z, Peng X, Zhu B, Zhang Y, Xi X. Active mobilization for mechanically ventilated patients: a systematic review. Arch Phys Med Rehabil. 2013 Mar;94(3):551-61. doi: 10.1016/j.apmr.2012.10.023. Epub 2012 Nov 2.
PMID: 23127305
citation: Parker A, Sricharoenchai T, Needham DM. Early Rehabilitation in the Intensive Care Unit: Preventing Physical and Mental Health Impairments. Curr Phys Med Rehabil Rep. 2013 Dec;1(4):307-314. doi: 10.1007/s40141-013-0027-9.
PMID: 24436844
citation: Adler J, Malone D. Early mobilization in the intensive care unit: a systematic review. Cardiopulm Phys Ther J. 2012 Mar;23(1):5-13.
PMID: 22807649
citation: Mendez-Tellez PA, Nusr R, Feldman D, Needham DM. Early Physical Rehabilitation in the ICU: A Review for the Neurohospitalist. Neurohospitalist. 2012 Jul;2(3):96-105. doi: 10.1177/1941874412447631.
PMID: 23983871
citation: Morris PE, Griffin L, Berry M, Thompson C, Hite RD, Winkelman C, Hopkins RO, Ross A, Dixon L, Leach S, Haponik E. Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci. 2011 May;341(5):373-7. doi: 10.1097/MAJ.0b013e31820ab4f6.
PMID: 21358312
citation: Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, Brower RG, Fan E. Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil. 2010 Apr;91(4):536-42. doi: 10.1016/j.apmr.2010.01.002.
PMID: 20382284
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responsible party type: Sponsor-Investigator
investigator affiliation: Papageorgiou General Hospital
investigator full name: Dimitris Chatzitheodorou
investigator title: Principal Investigator, Senior Physical Therapist
mesh term: Coronary Artery Disease
mesh term: Aortic Valve Disease
sharing ipd: No
submitted: December 21, 2021
returned: March 10, 2022