<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03759574</url>
  </required_header>
  <id_info>
    <org_study_id>H-18052195</org_study_id>
    <nct_id>NCT03759574</nct_id>
  </id_info>
  <brief_title>Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty (THA)</brief_title>
  <official_title>Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Hvidovre University Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Kehlet, Henrik, M.D., Ph.D.</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Hvidovre University Hospital</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Incidence and pathophysiologic hemodynamics of orthostatic intolerance and orthostatic&#xD;
      hypotension in patients undergoing unilateral THA&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Early postoperative mobilization is a cornerstone in the so-called fast track multimodal&#xD;
      perioperative approach and is essential in preventing postoperative morbidity and reducing&#xD;
      hospital length-of-stay. Intact orthostatic blood pressure regulation is essential for early&#xD;
      postoperative mobilization. However, early postoperative mobilization can be delayed due to&#xD;
      postoperative orthostatic hypotension (POH) defined as a fall in systolic pressure &gt; 20 mmHg&#xD;
      and/or diastolic pressure &gt; 10 mmHg or due to postoperative orthostatic intolerance (POI),&#xD;
      characterized by dizziness, nausea, vomiting, blurred vision or syncope during mobilization.&#xD;
      Although these conditions are well-known clinical problems that can delay early mobilization,&#xD;
      relatively few data are available on pathophysiological mechanisms and possible treatments.&#xD;
&#xD;
      Several prospective studies with standardized mobilization procedures have already&#xD;
      established that the incidence of POI and POH after THA is 38-42% at 6 hours after surgery.&#xD;
&#xD;
      Previous studies on patients undergoing prostatectomy and THA have also demonstrated that&#xD;
      attenuated vasopressor response and a concomitant reduction in cardiac output (CO) and&#xD;
      cerebral perfusion during postural changes after surgery contributes to POI and POH.&#xD;
      Strategies aiming to reduce the incidence of POI and POH by pain management, vasoconstrictive&#xD;
      treatment with alpha-1 receptor agonist, optimized fluid management with goal-directed fluid&#xD;
      therapy and reduction of surgical stress-response with pre-operative high-dose glucocorticoid&#xD;
      did not solve the problem.&#xD;
&#xD;
      The precise pathophysiological mechanisms of POI and POH remain to be elucidated and this is&#xD;
      therefore the aim of the current prospective observational study.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">March 18, 2019</start_date>
  <completion_date type="Anticipated">May 15, 2021</completion_date>
  <primary_completion_date type="Anticipated">January 1, 2021</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Incidence of orthostatic intolerance</measure>
    <time_frame>6 hours postoperatively</time_frame>
    <description>Symptoms of orthostatic intolerance: dizziness, nausea, vomiting, blurry vision or syncope during mobilization</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Incidence of orthostatic hypotension</measure>
    <time_frame>6 hours postoperatively</time_frame>
    <description>Orthostatic hypotension is defined as a fall in systolic pressure &gt; 20 mmHg and/or diastolic pressure &gt; 10 mmHg during mobilization</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Changes in systolic arterial pressure (SAP) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mmHg</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in diastolic arterial pressure (DAP) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mmHg</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in mean arterial pressure (MAP) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mmHg</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in systemic vascular resistance (SVR) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mmHg⋅min⋅mL-1</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in cardiac output (CO) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mL/min</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in stroke volume (SV) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mL</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in heart rate variability (HRV) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in ms</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in baroreflex sensitivity (BRS) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in ms/mmHg</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in peripheral perfusion index (PPI) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in arbitrary units (AU)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in cerebral perfusion (ScO2) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in %</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in muscular perfusion (SmO2) during mobilization</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in %</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in total blood volume (TBV)</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mL</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in erythrocyte volume (ECV)</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mL</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in plasma volume (PV)</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mL</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in hematocrit</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in %</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in haemoglobin (Hgb) concentration</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in millimoles/L</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes in C-Reactive Protein</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mg/L</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Pain score</measure>
    <time_frame>Preoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured by verbal rating scale (VRS) from 0 to 10 (0 = no pain, 10 = worse pain imaginable)</description>
  </other_outcome>
  <other_outcome>
    <measure>Estimated bleeding</measure>
    <time_frame>Intraoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mL</description>
  </other_outcome>
  <other_outcome>
    <measure>Opioid use</measure>
    <time_frame>6 and 24 hours postoperatively</time_frame>
    <description>Measured in mg</description>
  </other_outcome>
  <other_outcome>
    <measure>Cumulative fluid administration and losses</measure>
    <time_frame>Intraoperatively, 6 and 24 hours postoperatively</time_frame>
    <description>Measured in mg</description>
  </other_outcome>
  <number_of_groups>2</number_of_groups>
  <enrollment type="Anticipated">26</enrollment>
  <condition>Orthostatic Intolerance</condition>
  <condition>Orthostatic Hypotension</condition>
  <condition>Postoperative Complications</condition>
  <arm_group>
    <arm_group_label>Orthostatic intolerant (OI)</arm_group_label>
    <description>Patients that experience symptoms of orthostatic intolerance (dizziness, nausea, vomiting, blurry vision or syncope) or orthostatic hypotension (fall in systolic pressure &gt; 20 mmHg and/or diastolic pressure &gt; 10 mmHg) during mobilisation</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Orthostatic tolerant (OT)</arm_group_label>
    <description>Patients that do not experience symptoms of orthostatic intolerance (dizziness, nausea, vomiting, blurry vision or syncope) or orthostatic hypotension (fall in systolic pressure &gt; 20 mmHg and/or diastolic pressure &gt; 10 mmHg) during mobilisation</description>
  </arm_group>
  <eligibility>
    <study_pop>
      <textblock>
        Patients undergoing primary unilateral total hip arthroplasty in spinal anesthesia in&#xD;
        standardized fast-track setting&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Age 18-65&#xD;
&#xD;
          -  Written informed consent&#xD;
&#xD;
          -  Patients that speak and understand Danish&#xD;
&#xD;
          -  Patients undergoing primary unilateral total hip arthroplasty in spinal anesthesia in&#xD;
             standardized fast-track setting&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Alcohol and drug abuse&#xD;
&#xD;
          -  Cognitive dysfunction&#xD;
&#xD;
          -  History of orthostatic hypotension&#xD;
&#xD;
          -  Use of anxiolytic or antipsychotic drugs&#xD;
&#xD;
          -  Use of opioids&#xD;
&#xD;
          -  Use of following vasodilator antihypertensive drugs: beta-blockers, angiotensin&#xD;
             converting enzyme inhibitors (ACEI), angiotensin 2 receptor blockers (ARBs), calcium&#xD;
             channel blockers&#xD;
&#xD;
          -  Use of loop diuretics, thiazid diuretics and potassium-sparing diuretics&#xD;
&#xD;
          -  Use of Gabapentin&#xD;
&#xD;
          -  Arrhythmias or heart failure&#xD;
&#xD;
          -  Diabetes mellitus type I&#xD;
&#xD;
          -  Diabetes mellitus type II&#xD;
&#xD;
          -  History of following diseases in the autonomic nervous system: Parkinson disease,&#xD;
             multiple sclerosis, autonomic neuropathies&#xD;
&#xD;
          -  History of cerebral apoplexy or transitory cerebral ischemia&#xD;
&#xD;
          -  Dementia&#xD;
&#xD;
          -  American Society of Anesthesiologists (ASA) score ≥ 4&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>65 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_contact>
    <last_name>Ana-Marija Hristovska, MD</last_name>
    <phone>+4538621508</phone>
    <email>ana-marija.hristovska.02@regionh.dk</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Nicolai Foss, MD</last_name>
    <email>nicolai.bang.foss@regionh.dk</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Hvidovre Hospital</name>
      <address>
        <city>Copenhagen</city>
        <country>Denmark</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Ana-Marija Hristovska, MD</last_name>
    </contact>
  </location>
  <location_countries>
    <country>Denmark</country>
  </location_countries>
  <reference>
    <citation>Jans O, Bundgaard-Nielsen M, Solgaard S, Johansson PI, Kehlet H. Orthostatic intolerance during early mobilization after fast-track hip arthroplasty. Br J Anaesth. 2012 Mar;108(3):436-43. doi: 10.1093/bja/aer403. Epub 2011 Dec 15.</citation>
    <PMID>22174345</PMID>
  </reference>
  <reference>
    <citation>Lindberg-Larsen V, Petersen PB, Jans O, Beck T, Kehlet H. Effect of pre-operative methylprednisolone on orthostatic hypotension during early mobilization after total hip arthroplasty. Acta Anaesthesiol Scand. 2018 Aug;62(7):882-892. doi: 10.1111/aas.13108. Epub 2018 Mar 24.</citation>
    <PMID>29573263</PMID>
  </reference>
  <reference>
    <citation>Jans O, Mehlsen J, Kjaersgaard-Andersen P, Husted H, Solgaard S, Josiassen J, Lunn TH, Kehlet H. Oral Midodrine Hydrochloride for Prevention of Orthostatic Hypotension during Early Mobilization after Hip Arthroplasty: A Randomized, Double-blind, Placebo-controlled Trial. Anesthesiology. 2015 Dec;123(6):1292-300. doi: 10.1097/ALN.0000000000000890.</citation>
    <PMID>26492477</PMID>
  </reference>
  <reference>
    <citation>Bundgaard-Nielsen M, Jans O, Muller RG, Korshin A, Ruhnau B, Bie P, Secher NH, Kehlet H. Does goal-directed fluid therapy affect postoperative orthostatic intolerance?: A randomized trial. Anesthesiology. 2013 Oct;119(4):813-23. doi: 10.1097/ALN.0b013e31829ce4ea.</citation>
    <PMID>23756453</PMID>
  </reference>
  <reference>
    <citation>Jans O, Kehlet H. Postoperative orthostatic intolerance: a common perioperative problem with few available solutions. Can J Anaesth. 2017 Jan;64(1):10-15. doi: 10.1007/s12630-016-0734-7. Epub 2016 Sep 14. No abstract available.</citation>
    <PMID>27638295</PMID>
  </reference>
  <verification_date>January 2020</verification_date>
  <study_first_submitted>November 28, 2018</study_first_submitted>
  <study_first_submitted_qc>November 28, 2018</study_first_submitted_qc>
  <study_first_posted type="Actual">November 30, 2018</study_first_posted>
  <last_update_submitted>January 27, 2020</last_update_submitted>
  <last_update_submitted_qc>January 27, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">January 28, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Hvidovre University Hospital</investigator_affiliation>
    <investigator_full_name>Ana-Marija Hristovska</investigator_full_name>
    <investigator_title>Prinicial Investigator, Medical Doctor, PhD-student</investigator_title>
  </responsible_party>
  <keyword>Orthostatic Intolerance</keyword>
  <keyword>Orthostatic Hypotension</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Hypotension, Orthostatic</mesh_term>
    <mesh_term>Orthostatic Intolerance</mesh_term>
    <mesh_term>Hypotension</mesh_term>
    <mesh_term>Postoperative Complications</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03759574
org study id: H-18052195
nct id: NCT03759574
lead sponsor: 
collaborator: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
Incidence and pathophysiologic hemodynamics of orthostatic intolerance and orthostatic
      hypotension in patients undergoing unilateral THA
Early postoperative mobilization is a cornerstone in the so-called fast track multimodal
      perioperative approach and is essential in preventing postoperative morbidity and reducing
      hospital length-of-stay. Intact orthostatic blood pressure regulation is essential for early
      postoperative mobilization. However, early postoperative mobilization can be delayed due to
      postoperative orthostatic hypotension (POH) defined as a fall in systolic pressure > 20 mmHg
      and/or diastolic pressure > 10 mmHg or due to postoperative orthostatic intolerance (POI),
      characterized by dizziness, nausea, vomiting, blurred vision or syncope during mobilization.
      Although these conditions are well-known clinical problems that can delay early mobilization,
      relatively few data are available on pathophysiological mechanisms and possible treatments.

      Several prospective studies with standardized mobilization procedures have already
      established that the incidence of POI and POH after THA is 38-42% at 6 hours after surgery.

      Previous studies on patients undergoing prostatectomy and THA have also demonstrated that
      attenuated vasopressor response and a concomitant reduction in cardiac output (CO) and
      cerebral perfusion during postural changes after surgery contributes to POI and POH.
      Strategies aiming to reduce the incidence of POI and POH by pain management, vasoconstrictive
      treatment with alpha-1 receptor agonist, optimized fluid management with goal-directed fluid
      therapy and reduction of surgical stress-response with pre-operative high-dose glucocorticoid
      did not solve the problem.

      The precise pathophysiological mechanisms of POI and POH remain to be elucidated and this is
      therefore the aim of the current prospective observational study.
observational model: Cohort
time perspective: Prospective
measure: Incidence of orthostatic intolerance
time frame: 6 hours postoperatively
description: Symptoms of orthostatic intolerance: dizziness, nausea, vomiting, blurry vision or syncope during mobilization
measure: Incidence of orthostatic hypotension
time frame: 6 hours postoperatively
description: Orthostatic hypotension is defined as a fall in systolic pressure > 20 mmHg and/or diastolic pressure > 10 mmHg during mobilization
measure: Changes in systolic arterial pressure (SAP) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mmHg
measure: Changes in diastolic arterial pressure (DAP) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mmHg
measure: Changes in mean arterial pressure (MAP) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mmHg
measure: Changes in systemic vascular resistance (SVR) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mmHg⋅min⋅mL-1
measure: Changes in cardiac output (CO) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mL/min
measure: Changes in stroke volume (SV) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mL
measure: Changes in heart rate variability (HRV) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in ms
measure: Changes in baroreflex sensitivity (BRS) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in ms/mmHg
measure: Changes in peripheral perfusion index (PPI) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in arbitrary units (AU)
measure: Changes in cerebral perfusion (ScO2) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in %
measure: Changes in muscular perfusion (SmO2) during mobilization
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in %
measure: Changes in total blood volume (TBV)
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mL
measure: Changes in erythrocyte volume (ECV)
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mL
measure: Changes in plasma volume (PV)
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mL
measure: Changes in hematocrit
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in %
measure: Changes in haemoglobin (Hgb) concentration
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in millimoles/L
measure: Changes in C-Reactive Protein
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured in mg/L
measure: Pain score
time frame: Preoperatively, 6 and 24 hours postoperatively
description: Measured by verbal rating scale (VRS) from 0 to 10 (0 = no pain, 10 = worse pain imaginable)
measure: Estimated bleeding
time frame: Intraoperatively, 6 and 24 hours postoperatively
description: Measured in mL
measure: Opioid use
time frame: 6 and 24 hours postoperatively
description: Measured in mg
measure: Cumulative fluid administration and losses
time frame: Intraoperatively, 6 and 24 hours postoperatively
description: Measured in mg
arm group label: Orthostatic intolerant (OI)
description: Patients that experience symptoms of orthostatic intolerance (dizziness, nausea, vomiting, blurry vision or syncope) or orthostatic hypotension (fall in systolic pressure > 20 mmHg and/or diastolic pressure > 10 mmHg) during mobilisation
arm group label: Orthostatic tolerant (OT)
description: Patients that do not experience symptoms of orthostatic intolerance (dizziness, nausea, vomiting, blurry vision or syncope) or orthostatic hypotension (fall in systolic pressure > 20 mmHg and/or diastolic pressure > 10 mmHg) during mobilisation
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: 65 Years
healthy volunteers: No
last name: Ana-Marija Hristovska, MD
phone: +4538621508
email: ana-marija.hristovska.02@regionh.dk
last name: Nicolai Foss, MD
email: nicolai.bang.foss@regionh.dk
facility: 
status: Recruiting
contact: 
country: Denmark
citation: Jans O, Bundgaard-Nielsen M, Solgaard S, Johansson PI, Kehlet H. Orthostatic intolerance during early mobilization after fast-track hip arthroplasty. Br J Anaesth. 2012 Mar;108(3):436-43. doi: 10.1093/bja/aer403. Epub 2011 Dec 15.
PMID: 22174345
citation: Lindberg-Larsen V, Petersen PB, Jans O, Beck T, Kehlet H. Effect of pre-operative methylprednisolone on orthostatic hypotension during early mobilization after total hip arthroplasty. Acta Anaesthesiol Scand. 2018 Aug;62(7):882-892. doi: 10.1111/aas.13108. Epub 2018 Mar 24.
PMID: 29573263
citation: Jans O, Mehlsen J, Kjaersgaard-Andersen P, Husted H, Solgaard S, Josiassen J, Lunn TH, Kehlet H. Oral Midodrine Hydrochloride for Prevention of Orthostatic Hypotension during Early Mobilization after Hip Arthroplasty: A Randomized, Double-blind, Placebo-controlled Trial. Anesthesiology. 2015 Dec;123(6):1292-300. doi: 10.1097/ALN.0000000000000890.
PMID: 26492477
citation: Bundgaard-Nielsen M, Jans O, Muller RG, Korshin A, Ruhnau B, Bie P, Secher NH, Kehlet H. Does goal-directed fluid therapy affect postoperative orthostatic intolerance?: A randomized trial. Anesthesiology. 2013 Oct;119(4):813-23. doi: 10.1097/ALN.0b013e31829ce4ea.
PMID: 23756453
citation: Jans O, Kehlet H. Postoperative orthostatic intolerance: a common perioperative problem with few available solutions. Can J Anaesth. 2017 Jan;64(1):10-15. doi: 10.1007/s12630-016-0734-7. Epub 2016 Sep 14. No abstract available.
PMID: 27638295
responsible party type: Principal Investigator
investigator affiliation: Hvidovre University Hospital
investigator full name: Ana-Marija Hristovska
investigator title: Prinicial Investigator, Medical Doctor, PhD-student
mesh term: Hypotension, Orthostatic
mesh term: Orthostatic Intolerance
mesh term: Hypotension
mesh term: Postoperative Complications
sharing ipd: No