<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03756818</url>
  </required_header>
  <id_info>
    <org_study_id>2017-0422</org_study_id>
    <secondary_id>NCI-2018-02665</secondary_id>
    <secondary_id>2017-0422</secondary_id>
    <secondary_id>P30CA016672</secondary_id>
    <nct_id>NCT03756818</nct_id>
  </id_info>
  <brief_title>TAK-659 and Paclitaxel in Treating Patients With Advanced Solid Tumors</brief_title>
  <official_title>A Phase I Study of TAK-659 and Paclitaxel in Patients With Advanced Solid Tumors</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>M.D. Anderson Cancer Center</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>National Cancer Institute (NCI)</agency>
      <agency_class>NIH</agency_class>
    </collaborator>
  </sponsors>
  <source>M.D. Anderson Cancer Center</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>Yes</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This phase I trial studies the best dose and side effects of TAK-659 and paclitaxel in&#xD;
      treating patients with advanced solid tumors. TAK-659 may stop the growth of tumor cells by&#xD;
      blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as&#xD;
      paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the&#xD;
      cells, by stopping them from dividing, or by stopping them from spreading. Giving TAK-659 and&#xD;
      paclitaxel may work better in treating patients with advanced solid tumors.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      PRIMARY OBJECTIVES:&#xD;
&#xD;
      I. To define the maximum tolerated doses (MTD) of mivavotinib (TAK-659) and paclitaxel.&#xD;
&#xD;
      II. To define the safety profiles of the combination.&#xD;
&#xD;
      SECONDARY OBJECTIVES:&#xD;
&#xD;
      I. To evaluate clinical response signals to the combination. II. To analyze pharmacokinetic&#xD;
      interactions between TAK-659 and paclitaxel. III. To assess predictive biomarkers (baseline&#xD;
      molecular mutation status) and/or resistant pathways by comparing molecular signatures at&#xD;
      baseline versus at time of relapse in patients who have achieved objective responses.&#xD;
&#xD;
      OUTLINE: This is a dose-escalation study of mivavotinib and paclitaxel.&#xD;
&#xD;
      Patients receive mivavotinib orally (PO) once daily (QD) and paclitaxel intravenously (IV)&#xD;
      over approximately 1 hour on days 1, 8, and 15. Cycles repeat every 28 days in the absence of&#xD;
      disease progression or unacceptable toxicity.&#xD;
&#xD;
      After completion of study treatment, patients are followed up at 28 days.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">March 5, 2019</start_date>
  <completion_date type="Actual">February 23, 2023</completion_date>
  <primary_completion_date type="Actual">February 23, 2023</primary_completion_date>
  <phase>Phase 1</phase>
  <study_type>Interventional</study_type>
  <study_design_info>
    <allocation>N/A</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>To define the maximum tolerated doses (MTD) of TAK-659 and paclitaxel</measure>
    <time_frame>Up to 4 years</time_frame>
    <description>This is a dose-escalation study of mivavotinib and paclitaxel</description>
  </primary_outcome>
  <number_of_arms>1</number_of_arms>
  <enrollment type="Actual">52</enrollment>
  <condition>Advanced Malignant Solid Neoplasm</condition>
  <condition>Ovarian Carcinoma</condition>
  <condition>Refractory Malignant Solid Neoplasm</condition>
  <condition>Refractory Ovarian Carcinoma</condition>
  <arm_group>
    <arm_group_label>Treatment (mivavotinib and paclitaxel)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Patients receive mivavotinib PO QD and paclitaxel IV over approximately 1 hour on days 1, 8, and 15. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Mivavotinib</intervention_name>
    <description>Given PO</description>
    <arm_group_label>Treatment (mivavotinib and paclitaxel)</arm_group_label>
    <other_name>Spleen Tyrosine Kinase Inhibitor TAK659</other_name>
    <other_name>syk Inhibitor TAK-659</other_name>
    <other_name>syk Inhibitor TAK659</other_name>
    <other_name>syk-Inhibitor TAK-659</other_name>
    <other_name>syk-Inhibitor TAK659</other_name>
    <other_name>TAK-659 Free Base</other_name>
    <other_name>TAK659 Free Base</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Paclitaxel</intervention_name>
    <description>Given IV</description>
    <arm_group_label>Treatment (mivavotinib and paclitaxel)</arm_group_label>
    <other_name>Anzatax</other_name>
    <other_name>Asotax</other_name>
    <other_name>Bristaxol</other_name>
    <other_name>Praxel</other_name>
    <other_name>Taxol</other_name>
    <other_name>Taxol Konzentrat</other_name>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Pharmacokinetic Study</intervention_name>
    <description>Correlative studies</description>
    <arm_group_label>Treatment (mivavotinib and paclitaxel)</arm_group_label>
    <other_name>PHARMACOKINETIC</other_name>
    <other_name>PK Study</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  All patients have advanced malignancy, including but not limited to high-grade&#xD;
             epithelial ovarian cancer or cancer harboring K-RAS mutation, either refractory to&#xD;
             standard therapy or for which no effective standard therapy is available&#xD;
&#xD;
          -  Patients must have measurable or evaluable disease, as defined by Response Evaluation&#xD;
             Criteria in Solid Tumors (RECIST) 1.1&#xD;
&#xD;
          -  Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1 and life&#xD;
             expectancy of greater than 3 months and/or other performance status of 0 to 1&#xD;
&#xD;
          -  Female patients who:&#xD;
&#xD;
               -  Are postmenopausal for at least 1 year before the screening visit, OR&#xD;
&#xD;
               -  Are surgically sterile, OR&#xD;
&#xD;
               -  If they are of childbearing potential, agree to practice 1 highly effective&#xD;
                  method of contraception and one additional effective (barrier) method at the same&#xD;
                  time, from the time of signing the informed consent through 180 days after the&#xD;
                  last dose of study drug, OR&#xD;
&#xD;
               -  Agree to practice true abstinence, when is in line with the preferred and usual&#xD;
                  lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation,&#xD;
                  symptothermal, postovulation methods), withdrawal, spermicides only, and&#xD;
                  lactational amenorrhea are not acceptable methods of contraception. Female and&#xD;
                  male condoms should not be used together)&#xD;
&#xD;
               -  Agree not to donate eggs (ova) during the course of this study or 180 days after&#xD;
                  receiving their last dose of study drug&#xD;
&#xD;
          -  Male patients, even if surgically sterilized (i.e., status post-vasectomy), who:&#xD;
&#xD;
               -  Agree to practice effective barrier contraception during the entire study&#xD;
                  treatment period and through 180 days after the last dose of study drug, or&#xD;
&#xD;
               -  Agree to practice true abstinence, when this is in line with the preferred and&#xD;
                  usual lifestyle of the subject. (Periodic abstinence [eg, calendar, ovulation,&#xD;
                  symptothermal, postovulation methods for the female partner] and withdrawal are&#xD;
                  not acceptable methods of contraception. Female and male condoms should not be&#xD;
                  used together.)&#xD;
&#xD;
               -  Agree not to donate sperm during the course of this study or within 180 days&#xD;
                  after receiving their last dose of study drug&#xD;
&#xD;
          -  Absolute neutrophil count (ANC) &gt;= 1,500/uL&#xD;
&#xD;
          -  Platelet count &gt;= 100,000/uL (red blood cell count [RBC] and platelet transfusion&#xD;
             allowed &gt;= 14 days before assessment)&#xD;
&#xD;
          -  Hemoglobin &gt;= 8 g/dL (RBC and platelet transfusion allowed &gt;= 14 days before&#xD;
             assessment)&#xD;
&#xD;
          -  Total bilirubin =&lt; 1.5 x the upper limit of the normal range (ULN) (except patients&#xD;
             with Gilbert's syndrome, who must have a total bilirubin =&lt; 3.0 mg/dL)&#xD;
&#xD;
          -  Aminotransferases alanine (ALT) and aspartate aminotransferase (AST) =&lt; 2.5 x ULN or&#xD;
             =&lt; 5 x ULN if hepatic metastasis&#xD;
&#xD;
          -  Serum creatinine =&lt; 1 x ULN and creatine clearance &gt;= 60 mL/min either as estimated by&#xD;
             the Cockcroft-Gault equation or based on urine collection (12 or 24 hours) if serum&#xD;
             creatinine is abnormal&#xD;
&#xD;
          -  Lipase =&lt; 1.5 x ULN with no clinical symptoms suggestive of pancreatitis or&#xD;
             cholecystitis&#xD;
&#xD;
          -  Amylase =&lt; 1.5 x ULN with no clinical symptoms suggestive of pancreatitis or&#xD;
             cholecystitis&#xD;
&#xD;
          -  Blood pressure =&lt; grade 1 (hypertensive patients are permitted if their blood pressure&#xD;
             is controlled to =&lt; grade 1 by hypertensive medications and glycosylated hemoglobin is&#xD;
             =&lt; 6.5%)&#xD;
&#xD;
          -  Recovered (=&lt; grade 1 toxicity) from the reversible effects of prior anticancer&#xD;
             therapy&#xD;
&#xD;
          -  Voluntary written consent must be given before performance of any study related&#xD;
             procedure not part of standard medical care, with the understanding that consent may&#xD;
             be withdrawn by the patient at any time without prejudice to future medical care&#xD;
&#xD;
          -  Patients may receive palliative radiation therapy immediately before or during the&#xD;
             treatment if the radiation therapy is not delivered to the sole target lesions&#xD;
&#xD;
          -  Patients must be able to take oral medications without medical history of&#xD;
             malabsorption or other chronic gastrointestinal disease, or conditions that may hamper&#xD;
             compliance and/or absorption of the study agents&#xD;
&#xD;
          -  Patients have prior therapy with a taxane&#xD;
&#xD;
          -  Patients agree to provide archival tissue block or 10 formalin-fixed paraffin-embedded&#xD;
             (FFPE) slides paraffin for use in pharmacodynamics correlative studies&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active&#xD;
             infection requiring intravenous antibiotics, symptomatic congestive heart failure (New&#xD;
             York Heart Association [NYHA] Class III or IV), or history of myocardial infarction,&#xD;
             unstable angina, stroke or transient ischemic attack within 6 months prior to study&#xD;
             enrollment&#xD;
&#xD;
          -  Active brain metastases or leptomeningeal metastases&#xD;
&#xD;
          -  Known hypersensitivity (eg, anaphylactic and anaphylactoid reactions) to any&#xD;
             particular combination drug will result in a patient being ineligible for inclusion in&#xD;
             that particular cohort&#xD;
&#xD;
          -  History of drug-induced pneumonitis requiring treatment with steroids; history of&#xD;
             idiopathic pulmonary fibrosis, organizing pneumonia, or evidence of active pneumonitis&#xD;
             on screening chest computed tomography (CT) scan; history of radiation pneumonitis in&#xD;
             the radiation field (fibrosis) is permitted&#xD;
&#xD;
          -  Female patients who are both lactating and breastfeeding or have a positive serum&#xD;
             pregnancy test during the screening period or a positive urine pregnancy test on day 1&#xD;
             before first dose of study drug&#xD;
&#xD;
          -  Any serious medical or psychiatric illness that could, in the investigator's opinion,&#xD;
             potentially interfere with the completion of treatment according to this protocol&#xD;
&#xD;
          -  Life-threatening illness unrelated to cancer that could, in the investigator's&#xD;
             opinion, make the patient not appropriate for this study&#xD;
&#xD;
          -  Known human immunodeficiency virus (HIV) positive&#xD;
&#xD;
          -  Known hepatitis B surface antigen positive, or known or suspected active hepatitis C&#xD;
             infection&#xD;
&#xD;
          -  Any treatment specific for systemic tumor control within 3 weeks prior to the&#xD;
             initiation of the study drugs; or within 2 weeks if cytotoxic agents were given weekly&#xD;
             (within 6 weeks for nitrosoureas or mitomycin C), or within 5 half-lives for targeted&#xD;
             agents with half-lives and pharmacodynamic effects lasting less than 4 days (that&#xD;
             includes but is not limited to erlotinib, sorafenib, sunitinib, bortezomib, and other&#xD;
             similar agents), or failure to recover from toxic effects of any therapy prior to the&#xD;
             study drug treatment&#xD;
&#xD;
          -  Any clinically significant comorbidities, such as uncontrolled pulmonary disease,&#xD;
             known impaired cardiac function or clinically significant cardiac disease (specified&#xD;
             below), active central nervous system (CNS) disease, active infection, or any other&#xD;
             condition that could compromise the patient's participation in the study. Patients&#xD;
             with any of the following cardiovascular conditions are excluded:&#xD;
&#xD;
               -  Acute myocardial infarction within 6 months before starting study drug&#xD;
&#xD;
               -  Current or history of New York Heart Association Class III or IV heart failure&#xD;
&#xD;
               -  Evidence of current, uncontrolled cardiovascular conditions including cardiac&#xD;
                  arrhythmias, angina, pulmonary hypertension, or electrocardiographic evidence of&#xD;
                  acute ischemia or active conduction system abnormalities&#xD;
&#xD;
               -  Fridericia corrected QT interval (QTcF) &gt; 450 milliseconds (msec) (men) or &gt; 475&#xD;
                  msec (women) on a 12-lead electrocardiogram (ECG) during the screening period&#xD;
&#xD;
               -  Abnormalities on 12-lead ECG including, but not limited to, changes in rhythm and&#xD;
                  intervals that, in the opinion of the investigator, are considered to be&#xD;
                  clinically significant&#xD;
&#xD;
          -  Use or consumption of any of the following substances:&#xD;
&#xD;
               -  Medications or supplements that are known to be inhibitors of P-glycoprotein (gp)&#xD;
                  and/or strong reversible inhibitors of CYP3A within 5 times the inhibitor&#xD;
                  half-life (if a reasonable half-life estimate is known), or within 7 days (if a&#xD;
                  reasonable half-life estimate is unknown), before the first dose of study drug.&#xD;
                  In general, the use of these agents is not permitted during the study except in&#xD;
                  cases where an adverse event (AE) must be managed&#xD;
&#xD;
               -  Medications or supplements that are known to be strong CYP3A mechanism-based&#xD;
                  inhibitors or strong CYP3A inducers and/or P-gp inducers within 7 days, or within&#xD;
                  5 times the inhibitor or inducer half-life (whichever is longer), before the&#xD;
                  first dose of study drug. In general, the use of these agents is not permitted&#xD;
                  during the study except in cases where an AE must be managed&#xD;
&#xD;
               -  Grapefruit-containing food or beverages within 5 days before the first dose of&#xD;
                  study drug. Note that grapefruit-containing food and beverages are not permitted&#xD;
                  during the study&#xD;
&#xD;
          -  Major surgery within 14 days before the first dose of study drug and not recovered&#xD;
             fully from any complications from surgery&#xD;
&#xD;
          -  Systemic infection requiring parenteral antibiotic therapy or other serious infection&#xD;
             (bacterial, fungal or viral) within 21 days before the first dose of study drug.&#xD;
             Patients who are at substantial risk of developing an infection may receive&#xD;
             prophylaxis at the study of study treatment per investigator's discretion&#xD;
&#xD;
          -  Active secondary malignancy that requires treatment. Patients with non-melanoma skin&#xD;
             cancer or carcinoma in situ of any type are not excluded if they have undergone&#xD;
             complete resection and are considered disease-free at the time of study entry&#xD;
&#xD;
          -  Known gastrointestinal (GI) disease or GI procedure that could interfere with the oral&#xD;
             absorption or tolerance of TAK-659 including difficulty swallowing tablets or diarrhea&#xD;
             &gt; grade 1 despite supportive therapy. History of abdominal fistula, gastrointestinal&#xD;
             perforation, or intra-abdominal abscess within 6 months prior to study enrollment&#xD;
&#xD;
          -  Patients with clinical bleeding, active gastric or duodenal ulcer&#xD;
&#xD;
          -  Grade 2 or higher peripheral neuropathy&#xD;
&#xD;
          -  Left ventricular ejection fraction (LVEF) is less than 50% on echocardiography (ECHO)&#xD;
             or multiple-gated acquisition (MUGA) scanning or QTc is greater than 450 milliseconds&#xD;
             (msec) for men and greater than 475 msec for women at screening&#xD;
&#xD;
          -  Treatment with high-dose corticosteroids for anticancer purposes within 14 days before&#xD;
             the first dose of TAK-659; daily dose equivalent to 10 mg oral prednisone or less is&#xD;
             permitted. Corticosteroids for topical use or in nasal spray or inhalers, or for&#xD;
             premedication for paclitaxel are allowed&#xD;
&#xD;
          -  Lack of suitable venous access for the study-required blood sampling&#xD;
&#xD;
          -  Grade 2 or higher ophthalmologic disease&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Siqing Fu</last_name>
    <role>Principal Investigator</role>
    <affiliation>M.D. Anderson Cancer Center</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>M D Anderson Cancer Center</name>
      <address>
        <city>Houston</city>
        <state>Texas</state>
        <zip>77030</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <verification_date>February 2023</verification_date>
  <study_first_submitted>November 26, 2018</study_first_submitted>
  <study_first_submitted_qc>November 27, 2018</study_first_submitted_qc>
  <study_first_posted type="Actual">November 28, 2018</study_first_posted>
  <last_update_submitted>February 24, 2023</last_update_submitted>
  <last_update_submitted_qc>February 24, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">February 28, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Carcinoma</mesh_term>
    <mesh_term>Neoplasms</mesh_term>
    <mesh_term>Ovarian Neoplasms</mesh_term>
    <mesh_term>Carcinoma, Ovarian Epithelial</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Paclitaxel</mesh_term>
    <mesh_term>Albumin-Bound Paclitaxel</mesh_term>
    <mesh_term>Tyrosine Protein Kinase Inhibitors</mesh_term>
  </intervention_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03756818
org study id: 2017-0422
secondary id: NCI-2018-02665
secondary id: 2017-0422
secondary id: P30CA016672
nct id: NCT03756818
lead sponsor: 
collaborator: 
has dmc: No
is fda regulated drug: Yes
is fda regulated device: No
This phase I trial studies the best dose and side effects of TAK-659 and paclitaxel in
      treating patients with advanced solid tumors. TAK-659 may stop the growth of tumor cells by
      blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as
      paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the
      cells, by stopping them from dividing, or by stopping them from spreading. Giving TAK-659 and
      paclitaxel may work better in treating patients with advanced solid tumors.
PRIMARY OBJECTIVES:

      I. To define the maximum tolerated doses (MTD) of mivavotinib (TAK-659) and paclitaxel.

      II. To define the safety profiles of the combination.

      SECONDARY OBJECTIVES:

      I. To evaluate clinical response signals to the combination. II. To analyze pharmacokinetic
      interactions between TAK-659 and paclitaxel. III. To assess predictive biomarkers (baseline
      molecular mutation status) and/or resistant pathways by comparing molecular signatures at
      baseline versus at time of relapse in patients who have achieved objective responses.

      OUTLINE: This is a dose-escalation study of mivavotinib and paclitaxel.

      Patients receive mivavotinib orally (PO) once daily (QD) and paclitaxel intravenously (IV)
      over approximately 1 hour on days 1, 8, and 15. Cycles repeat every 28 days in the absence of
      disease progression or unacceptable toxicity.

      After completion of study treatment, patients are followed up at 28 days.
allocation: N/A
intervention model: Single Group Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: To define the maximum tolerated doses (MTD) of TAK-659 and paclitaxel
time frame: Up to 4 years
description: This is a dose-escalation study of mivavotinib and paclitaxel
arm group label: Treatment (mivavotinib and paclitaxel)
arm group type: Experimental
description: Patients receive mivavotinib PO QD and paclitaxel IV over approximately 1 hour on days 1, 8, and 15. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
intervention type: Drug
intervention name: Mivavotinib
description: Given PO
arm group label: Treatment (mivavotinib and paclitaxel)
other name: Spleen Tyrosine Kinase Inhibitor TAK659
other name: syk Inhibitor TAK-659
other name: syk Inhibitor TAK659
other name: syk-Inhibitor TAK-659
other name: syk-Inhibitor TAK659
other name: TAK-659 Free Base
other name: TAK659 Free Base
intervention type: Drug
intervention name: Paclitaxel
description: Given IV
arm group label: Treatment (mivavotinib and paclitaxel)
other name: Anzatax
other name: Asotax
other name: Bristaxol
other name: Praxel
other name: Taxol
other name: Taxol Konzentrat
intervention type: Other
intervention name: Pharmacokinetic Study
description: Correlative studies
arm group label: Treatment (mivavotinib and paclitaxel)
other name: PHARMACOKINETIC
other name: PK Study
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Siqing Fu
role: Principal Investigator
affiliation: M.D. Anderson Cancer Center
facility: 
country: United States
responsible party type: Sponsor
mesh term: Carcinoma
mesh term: Neoplasms
mesh term: Ovarian Neoplasms
mesh term: Carcinoma, Ovarian Epithelial
mesh term: Paclitaxel
mesh term: Albumin-Bound Paclitaxel
mesh term: Tyrosine Protein Kinase Inhibitors