<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03840200</url>
  </required_header>
  <id_info>
    <org_study_id>BO40933</org_study_id>
    <nct_id>NCT03840200</nct_id>
  </id_info>
  <brief_title>A Study Evaluating the Safety, Pharmacokinetics and Efficacy of Ipatasertib Administered in Combination With Rucaparib in Participants With Advanced Breast, Ovarian Cancer, and Prostate Cancer.</brief_title>
  <official_title>A Phase Ib, Open-Label, Multicenter Study Evaluating the Safety and Efficacy of Ipatasertib in Combination With Rucaparib in Patients With Advanced Breast, Ovarian, or Prostate Cancer</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Hoffmann-La Roche</agency>
      <agency_class>Industry</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Hoffmann-La Roche</source>
  <oversight_info>
    <is_fda_regulated_drug>Yes</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This is a study in participants with advanced breast, ovarian, or prostate cancer to&#xD;
      investigate the dose, safety, pharmacokinetics, and preliminary efficacy of ipatasertib in&#xD;
      combination with rucaparib. The study consists of two parts: a Dose-Escalation Phase (Part 1)&#xD;
      in participants with previously treated advanced breast cancer, ovarian cancer, or prostate&#xD;
      cancer and a Dose-Expansion Phase (Part 2) in participants with advanced prostate cancer who&#xD;
      have had at least one line of prior therapy with second-generation androgen-receptor&#xD;
      (AR)-targeted agents (e.g., abiraterone, enzalutamide, apalutamide).&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      There are two parts in the study. A Dose-Escalation Phase (Part 1) in participants with&#xD;
      previously treated advanced breast cancer, ovarian cancer, or prostate cancer. There will be&#xD;
      a 7-day run-in period with ipatasertib alone prior to Cycle 1, Day 1. After the completion of&#xD;
      the ipatasertib run-in period, participants will begin Cycle 1, Day 1 of the ipatasertib and&#xD;
      rucaparib combination treatment. Each cycle has 28 days. Participants will be split into 4&#xD;
      cohorts: Dose Level 1 group - 300 mg ipatasertib once daily (QD) + 400 mg rucaparib twice&#xD;
      daily (BID), Dose Level 2a: 300 mg ipatasertib QD + 600 mg rucaparib BID, Dose Level 2b: 400&#xD;
      mg ipatasertib QD + 400 mg rucaparib BID, Dose Level 3: 400 mg ipatasertib QD + 600 mg&#xD;
      rucaparib BID&#xD;
&#xD;
      A Dose-Expansion Phase (Part 2) - The recommended dose identified in Part 1 (highest dose&#xD;
      level of ipatasertib and rucaparib with an acceptable safety profile and less than one-third&#xD;
      of participants experience a dose limiting toxicity) will be evaluated in participants with&#xD;
      advanced prostate cancer who have had at least one line of prior therapy with&#xD;
      second-generation androgen-receptor (AR)-targeted agents (e.g., abiraterone, enzalutamide,&#xD;
      apalutamide).&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">June 11, 2019</start_date>
  <completion_date type="Actual">January 4, 2022</completion_date>
  <primary_completion_date type="Actual">December 7, 2021</primary_completion_date>
  <phase>Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Non-Randomized</allocation>
    <intervention_model>Sequential Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Percentage of Participants with Adverse Events</measure>
    <time_frame>Baseline up to approximately 3 years</time_frame>
  </primary_outcome>
  <primary_outcome>
    <measure>Percentage of Participants with Dose-Limiting Toxicities (DLTs) that Determine the Maximum-Tolerated Dose (MTD) of the Ipatasertib and Rucaparib Combination</measure>
    <time_frame>Day -7 to Day 28 of Cycle 1; 1 cycle = 28 days</time_frame>
  </primary_outcome>
  <primary_outcome>
    <measure>Percentage of Participants with Prostate-Specific Antigen (PSA) Response</measure>
    <time_frame>At screening (&lt;=28 days of first dose), Day 1 of Cycle 1, 2, 3 and &gt;= 4, at treatment discontinuation and post-treatment follow-up (1 cycle = 28 days; baseline up to approximately 3 years)</time_frame>
  </primary_outcome>
  <secondary_outcome>
    <measure>Percentage of Participants with Objective Response, as Assessed by Investigator Based on Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v.1.1)</measure>
    <time_frame>At end of Cycle 2, 4, 6 and every 3 cycles thereafter up to progression (1 cycle = 28 days; baseline up to approximately 3 years)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Duration of Objective Response in Participants with Measurable Disease at Baseline, as Assessed by Investigator Based on RECIST v1.1</measure>
    <time_frame>At end of Cycle 2, 4, 6 and every 3 cycles thereafter up to progression (1 cycle = 28 days; baseline up to approximately 3 years)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Radiographic Progression Free Survival, as Assessed by Prostate Cancer Working Group 3 Criteria</measure>
    <time_frame>At end of Cycle 2, 4, 6 and every 3 cycles thereafter up to radiographic progression (1 cycle = 28 days; baseline up to approximately 3 years)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Overall Survival in All Participants</measure>
    <time_frame>Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 3 years)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Plasma Concentration of Ipatasertib</measure>
    <time_frame>Day -7, 1, 15 of Cycle 1, Day 1, 15 of Cycle 2 (1 cyce = 28 days)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Plasma Concentration of Ipatasertib's Metabolite, G-037720</measure>
    <time_frame>Day -7, 1, 15 of Cycle 1, Day 1, 15 of Cycle 2 (1 cycle = 28 days)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Plasma Concentration of Rucaparib</measure>
    <time_frame>Day -7, 1, 15 of Cycle 1, Day 1, 15 of Cycle 2 (1 cycle = 28 days)</time_frame>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">51</enrollment>
  <condition>Breast Cancer</condition>
  <condition>Prostate Cancer</condition>
  <condition>Ovarian Cancer</condition>
  <arm_group>
    <arm_group_label>Ipatasertib + Rucaparib</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>A Dose-Escalation Phase (Part 1) in participants with previously treated advanced breast cancer, ovarian cancer, or prostate cancer. There will be a 7-day run-in period with ipatasertib alone prior to Cycle 1, Day 1. After the completion of the ipatasertib run-in period, participants will begin Cycle 1, Day 1 of the ipatasertib and rucaparib combination treatment. Each cycle has 28 days. Participants will be split into 4 cohorts: Dose Level 1 group - 300 mg ipatasertib once daily (QD) + 400 mg rucaparib twice daily (BID), Dose Level 2a: 300 mg ipatasertib QD + 600 mg rucaparib BID, Dose Level 2b: 400 mg ipatasertib QD + 400 mg rucaparib BID, Dose Level 3: 400 mg ipatasertib QD + 600 mg rucaparib BID</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Part 2: Ipatasertib + Rucaparib</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>A Dose-Expansion Phase (Part 2) - The recommended dose identified in Part 1 (highest dose level of ipatasertib and rucaparib with an acceptable safety profile and less than one-third of participants experience a dose limiting toxicity) will be evaluated in participants with advanced prostate cancer who have had at least one line of prior therapy with second-generation androgen-receptor (AR)-targeted agents (e.g., abiraterone, enzalutamide, apalutamide).</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Part 1, Dose Level 1 and Dose Level 2a: Ipatasertib</intervention_name>
    <description>Ipatasertib, 300 mg administered PO QD for 7 days (run-in period prior to Cycle 1), then administer 300 mg PO QD for each cycle. Each cycle has 28 days. Doses are administered until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.</description>
    <arm_group_label>Ipatasertib + Rucaparib</arm_group_label>
    <arm_group_label>Part 2: Ipatasertib + Rucaparib</arm_group_label>
    <other_name>RO5532961, GDC-0068</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Part 1, Dose level 2b and dose level 3: Ipatasertib</intervention_name>
    <description>Ipatasertib, 400 mg administered PO QD for 7 days (run-in period prior to Cycle 1), then administer 400 mg PO QD for each cycle. One cycle has 28 days. Doses are administered until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.</description>
    <arm_group_label>Ipatasertib + Rucaparib</arm_group_label>
    <arm_group_label>Part 2: Ipatasertib + Rucaparib</arm_group_label>
    <other_name>RO5532961, GDC-0068</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Part 1, Dose Level 1 and Dose Level 2b: Rucaparib</intervention_name>
    <description>Rucaparib is administered 400 mg twice daily (BID) for each cycle. One cycle has 28 days. Doses are administered until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.</description>
    <arm_group_label>Ipatasertib + Rucaparib</arm_group_label>
    <arm_group_label>Part 2: Ipatasertib + Rucaparib</arm_group_label>
    <other_name>CO-338</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Part 1, Dose Level 2a and Dose Level 3: Rucaparib</intervention_name>
    <description>Rucaparib is administered 600 mg twice daily (BID) for each cycle. One cycle has 28 days. Doses are administered until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.</description>
    <arm_group_label>Ipatasertib + Rucaparib</arm_group_label>
    <arm_group_label>Part 2: Ipatasertib + Rucaparib</arm_group_label>
    <other_name>CO-338</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1&#xD;
&#xD;
          -  A life expectancy of at least 3 months&#xD;
&#xD;
          -  Ability to swallow oral study drug&#xD;
&#xD;
          -  Have adequate organ and marrow function as confirmed by the laboratory values listed&#xD;
             below, obtained within 28 days prior to the first dose of study treatment:&#xD;
&#xD;
          -  Bone marrow function assessments (without transfusion within 28 days prior to receipt&#xD;
             of study treatment):&#xD;
&#xD;
               1. ANC &gt;= 1500 cells/uL (1.5 x 10^9/L) without granulocyte-colony stimulating factor&#xD;
                  support&#xD;
&#xD;
               2. Platelet count &gt;= 100.0 x 10^9/L&#xD;
&#xD;
               3. Hemoglobin &gt;= 9 g/dL (or 5.6 mmol/L)&#xD;
&#xD;
          -  Chemistry panel assessments:&#xD;
&#xD;
               1. AST and ALT &lt;= 1.5 x upper limit of normal (ULN); if liver metastases, &lt;= 2.5 x&#xD;
                  ULN&#xD;
&#xD;
               2. Bilirubin &lt;= 1.5 x ULN (&lt;= 3 x ULN if hyperbilirubinemia is due to Gilbert's&#xD;
                  syndrome)&#xD;
&#xD;
               3. Serum albumin &gt;= 3.0 g/dL&#xD;
&#xD;
               4. Serum creatinine &lt;= 1.5 x ULN or creatinine clearance &gt;= 50 mL/min&#xD;
&#xD;
               5. Fasting glucose &lt;= 150 mg/dL and hemoglobin A1c &lt;= 7.5%&#xD;
&#xD;
          -  Resolved or stabilized toxicities resulting from previous therapy to Grade 1 (except&#xD;
             for alopecia and neuropathy).&#xD;
&#xD;
        Cancer-Related Inclusion Criteria&#xD;
&#xD;
          -  Have a histologically confirmed diagnosis of ovarian (Part 1 only), breast (Part 1&#xD;
             only) or prostate cancer (Part 1 and Part 2)&#xD;
&#xD;
          -  Disease must be either metastatic or locally advanced disease that cannot be treated&#xD;
             with curative intent&#xD;
&#xD;
          -  For patients with ovarian cancer (Part 1 only):&#xD;
&#xD;
               1. High-grade (2 or 3) serous or endometrioid or clear cell epithelial ovarian,&#xD;
                  fallopian tube, or primary peritoneal cancer (PPC)&#xD;
&#xD;
               2. Must have received at least one prior platinum-based therapy and may have&#xD;
                  platinumsensitive disease (i.e., documented radiologic disease progression &gt;= 6&#xD;
                  months following the last dose of the platinum treatment administered) or&#xD;
                  platinum-resistant disease&#xD;
&#xD;
               3. Have a CA-125 level that is &gt; 2 x ULN&#xD;
&#xD;
               4. Must have measurable disease by RECIST v1.1&#xD;
&#xD;
          -  For patients with breast cancer (Part 1 only): must be human epidermal growth factor&#xD;
             receptor 2 negative (HER2-) (estrogen receptor [ER]/progesterone positive or&#xD;
             negative):&#xD;
&#xD;
               1. ER/progesterone-positive patients must have received and progressed on at least&#xD;
                  one endocrine therapy (adjuvant or metastatic)&#xD;
&#xD;
               2. ER/progesterone-negative/HER2- (triple-negative breast cancer [TNBC]) patients&#xD;
                  must have received at least one prior line of chemotherapy for metastatic breast&#xD;
                  cancer&#xD;
&#xD;
               3. Must not have received more than two prior lines of chemotherapy for metastatic&#xD;
                  breast cancer&#xD;
&#xD;
               4. Must have measurable disease by RECIST v1.1&#xD;
&#xD;
        For patients with prostate cancer:&#xD;
&#xD;
          1. Adenocarcinoma of the prostate without small cell or neuroendocrine features&#xD;
&#xD;
          2. Surgical or medical castration with testosterone &lt; 50 ng/dL (1.7 nM)&#xD;
&#xD;
          3. Patients treated with luteinizing hormone-releasing hormone analogs must have&#xD;
             initiated therapy at least 4 weeks prior to the first dose of study treatment and&#xD;
             continue throughout the study treatment&#xD;
&#xD;
          4. Progression of prostate cancer either via PSA progression (two rising PSA levels&#xD;
             measured &gt;= 1 week apart, with second result &gt;= 1 ng/mL) or radiographic progression&#xD;
             with or without PSA progression&#xD;
&#xD;
          5. Must have received at least one prior line of second-generation androgen receptor&#xD;
             targeted therapy (e.g., abiraterone, enzalutamide, apalutamide)&#xD;
&#xD;
          6. Patients with prostate cancer must have either measurable disease by RECIST v1.1 or&#xD;
             bone lesions by bone scan, or both.&#xD;
&#xD;
               -  Submission of a formalin-fixed, paraffin-embedded (FFPE) tumor tissue block or a&#xD;
                  minimum of 12 freshly cut, unstained, serial tumor slides from the most recently&#xD;
                  collected tumor tissue for central molecular analysis (retrospective NGS testing&#xD;
                  for HR and PI3K-AKT pathway status and for other protocol-mandated secondary and&#xD;
                  exploratory assessments). Cytologic or fine needle aspirate samples are not&#xD;
                  acceptable. Tumor tissue from bone metastases is not acceptable.&#xD;
&#xD;
               -  For men and women of child bearing potential: agreement to remain abstinent or&#xD;
                  use protocol defined contraceptive measures during the treatment period and for&#xD;
                  at least 28 days after the last dose of ipatasertib,or 6 months after the last&#xD;
                  dose of rucaparib, whichever occurs later&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Pregnant or breastfeeding, or intending to become pregnant during the study or within&#xD;
             28 days after the final dose of ipatasertib or 6 months after the final dose of&#xD;
             rucaparib&#xD;
&#xD;
          -  Prior treatment with a PARP inhibitor, AKT inhibitor, or PI3K inhibitor&#xD;
&#xD;
          -  Treatment with investigational therapy within 14 days prior to initiation of study&#xD;
             drug&#xD;
&#xD;
          -  Symptomatic and/or untreated CNS metastases&#xD;
&#xD;
          -  Uncontrolled tumor-related pain&#xD;
&#xD;
          -  Non-study-related minor surgical procedures &lt;= 5 days or major (invasive) surgical&#xD;
             procedure &lt;=14 days prior to first dose of study treatment&#xD;
&#xD;
          -  Patients with active hepatitis C virus (HCV)&#xD;
&#xD;
          -  Hepatitis B virus (HBV) infection (chronic or acute), defined as having a positive&#xD;
             hepatitis B surface antigen (HBsAg) test or a positive quantitative HBV DNA test&#xD;
&#xD;
          -  Known HIV infection&#xD;
&#xD;
          -  Illicit drug or alcohol abuse within 12 months prior to screening, in the&#xD;
             investigator's judgment&#xD;
&#xD;
          -  Malabsorption syndrome or other condition that would interfere with enteral absorption&#xD;
&#xD;
          -  Serious infection requiring antibiotics within 14 days of first dose of study&#xD;
             treatment&#xD;
&#xD;
          -  Any serious medical condition or abnormality in clinical laboratory tests that, in the&#xD;
             investigator's judgment, precludes the patient's safe participation in and completion&#xD;
             of the study&#xD;
&#xD;
          -  Need for chronic corticosteroid therapy of &gt;= 10 mg of prednisone per day or an&#xD;
             equivalent dose of other anti-inflammatory corticosteroids or immunosuppressants for a&#xD;
             chronic disease&#xD;
&#xD;
          -  History of another malignancy within 5 years prior to randomization, except for either&#xD;
             adequately treated non-melanomatous carcinoma of the skin, adequately treated melanoma&#xD;
             in situ, adequately treated non-muscle-invasive urothelial carcinoma of the bladder&#xD;
             (Tis, Ta, and low-grade T1 tumors), or other malignancies where the patient has&#xD;
             undergone potentially curative therapy with no evidence of disease and are deemed by&#xD;
             the treating physician to have a recurrence rate of &lt; 5% at 5 years.&#xD;
&#xD;
          -  History of clinically significant cardiovascular dysfunction&#xD;
&#xD;
          -  Presence of any other condition that may have increased the risk associated with study&#xD;
             participation or may have interfered with the interpretation of study results, and, in&#xD;
             the opinion of the investigator, would have made the patient inappropriate for entry&#xD;
             into the study&#xD;
&#xD;
        Ipatasertib-Specific Exclusion Criteria:&#xD;
&#xD;
          -  Type 1 or Type 2 diabetes mellitus requiring insulin at study entry&#xD;
&#xD;
          -  History of inflammatory bowel disease (e.g., Crohn disease and ulcerative colitis),&#xD;
             active bowel inflammation (e.g., diverticulitis)&#xD;
&#xD;
          -  Treatment with strong CYP3A inhibitors or strong CYP3A inducers within 4 weeks or five&#xD;
             elimination half-live of the inhibitors, whichever is longer, prior to initiation of&#xD;
             study drug&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Clinical Trials</last_name>
    <role>Study Director</role>
    <affiliation>Hoffmann-La Roche</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>California Cancer Associates for Research &amp; Excellence, Inc.</name>
      <address>
        <city>San Marcos</city>
        <state>California</state>
        <zip>92069</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Regional Cancer Care Associates LLC, Central Jersey Division</name>
      <address>
        <city>East Brunswick</city>
        <state>New Jersey</state>
        <zip>08816</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Fox Chase Cancer Center</name>
      <address>
        <city>Philadelphia</city>
        <state>Pennsylvania</state>
        <zip>19111</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Mary Crowley Medical Research Center; Oncology</name>
      <address>
        <city>Dallas</city>
        <state>Texas</state>
        <zip>75246</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Kinghorn Cancer Centre; St Vincents Hospital</name>
      <address>
        <city>Darlinghurst</city>
        <state>New South Wales</state>
        <zip>2010</zip>
        <country>Australia</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Macquarie University Hospital</name>
      <address>
        <city>Macquarie Park</city>
        <state>New South Wales</state>
        <zip>2109</zip>
        <country>Australia</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Cabrini Hospital Malvern</name>
      <address>
        <city>Malvern</city>
        <state>Victoria</state>
        <zip>3144</zip>
        <country>Australia</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Istituto Nazionale Tumori Regina Elena IRCCS</name>
      <address>
        <city>Roma</city>
        <state>Lazio</state>
        <zip>00144</zip>
        <country>Italy</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Fondazione IRCCS Istituto Nazionale dei Tumori; S. C. Oncologia Medica 2</name>
      <address>
        <city>Milano</city>
        <state>Lombardia</state>
        <zip>20133</zip>
        <country>Italy</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Azienda Ospedaliera Santa Maria di Terni</name>
      <address>
        <city>Terni</city>
        <state>Umbria</state>
        <zip>20089</zip>
        <country>Italy</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Istituto Oncologico Veneto IRCCS</name>
      <address>
        <city>Padova</city>
        <state>Veneto</state>
        <zip>35128</zip>
        <country>Italy</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Seoul National University Hospital</name>
      <address>
        <city>Seoul</city>
        <zip>03080</zip>
        <country>Korea, Republic of</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Severance Hospital, Yonsei University</name>
      <address>
        <city>Seoul</city>
        <zip>03722</zip>
        <country>Korea, Republic of</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Samsung Medical Center</name>
      <address>
        <city>Seoul</city>
        <zip>06351</zip>
        <country>Korea, Republic of</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Clínica Universidad de Navarra</name>
      <address>
        <city>Pamplona</city>
        <state>Navarra</state>
        <zip>31620</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Vall d´Hebron Institute of Oncology (VHIO), Barcelona</name>
      <address>
        <city>Barcelona</city>
        <zip>08035</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Hospital Universitario Virgen de la Victoria</name>
      <address>
        <city>Malaga</city>
        <zip>29010</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Australia</country>
    <country>Italy</country>
    <country>Korea, Republic of</country>
    <country>Spain</country>
    <country>United States</country>
  </location_countries>
  <verification_date>January 2022</verification_date>
  <study_first_submitted>February 11, 2019</study_first_submitted>
  <study_first_submitted_qc>February 11, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">February 15, 2019</study_first_posted>
  <last_update_submitted>January 25, 2022</last_update_submitted>
  <last_update_submitted_qc>January 25, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">February 9, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Prostatic Neoplasms</mesh_term>
    <mesh_term>Ovarian Neoplasms</mesh_term>
    <mesh_term>Carcinoma, Ovarian Epithelial</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Rucaparib</mesh_term>
    <mesh_term>Ipatasertib</mesh_term>
  </intervention_browse>
  <pending_results>
    <submitted>December 2, 2022</submitted>
  </pending_results>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03840200
org study id: BO40933
nct id: NCT03840200
lead sponsor: 
is fda regulated drug: Yes
is fda regulated device: No
This is a study in participants with advanced breast, ovarian, or prostate cancer to
      investigate the dose, safety, pharmacokinetics, and preliminary efficacy of ipatasertib in
      combination with rucaparib. The study consists of two parts: a Dose-Escalation Phase (Part 1)
      in participants with previously treated advanced breast cancer, ovarian cancer, or prostate
      cancer and a Dose-Expansion Phase (Part 2) in participants with advanced prostate cancer who
      have had at least one line of prior therapy with second-generation androgen-receptor
      (AR)-targeted agents (e.g., abiraterone, enzalutamide, apalutamide).
There are two parts in the study. A Dose-Escalation Phase (Part 1) in participants with
      previously treated advanced breast cancer, ovarian cancer, or prostate cancer. There will be
      a 7-day run-in period with ipatasertib alone prior to Cycle 1, Day 1. After the completion of
      the ipatasertib run-in period, participants will begin Cycle 1, Day 1 of the ipatasertib and
      rucaparib combination treatment. Each cycle has 28 days. Participants will be split into 4
      cohorts: Dose Level 1 group - 300 mg ipatasertib once daily (QD) + 400 mg rucaparib twice
      daily (BID), Dose Level 2a: 300 mg ipatasertib QD + 600 mg rucaparib BID, Dose Level 2b: 400
      mg ipatasertib QD + 400 mg rucaparib BID, Dose Level 3: 400 mg ipatasertib QD + 600 mg
      rucaparib BID

      A Dose-Expansion Phase (Part 2) - The recommended dose identified in Part 1 (highest dose
      level of ipatasertib and rucaparib with an acceptable safety profile and less than one-third
      of participants experience a dose limiting toxicity) will be evaluated in participants with
      advanced prostate cancer who have had at least one line of prior therapy with
      second-generation androgen-receptor (AR)-targeted agents (e.g., abiraterone, enzalutamide,
      apalutamide).
allocation: Non-Randomized
intervention model: Sequential Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Percentage of Participants with Adverse Events
time frame: Baseline up to approximately 3 years
measure: Percentage of Participants with Dose-Limiting Toxicities (DLTs) that Determine the Maximum-Tolerated Dose (MTD) of the Ipatasertib and Rucaparib Combination
time frame: Day -7 to Day 28 of Cycle 1; 1 cycle = 28 days
measure: Percentage of Participants with Prostate-Specific Antigen (PSA) Response
time frame: At screening (<=28 days of first dose), Day 1 of Cycle 1, 2, 3 and >= 4, at treatment discontinuation and post-treatment follow-up (1 cycle = 28 days; baseline up to approximately 3 years)
measure: Percentage of Participants with Objective Response, as Assessed by Investigator Based on Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v.1.1)
time frame: At end of Cycle 2, 4, 6 and every 3 cycles thereafter up to progression (1 cycle = 28 days; baseline up to approximately 3 years)
measure: Duration of Objective Response in Participants with Measurable Disease at Baseline, as Assessed by Investigator Based on RECIST v1.1
time frame: At end of Cycle 2, 4, 6 and every 3 cycles thereafter up to progression (1 cycle = 28 days; baseline up to approximately 3 years)
measure: Radiographic Progression Free Survival, as Assessed by Prostate Cancer Working Group 3 Criteria
time frame: At end of Cycle 2, 4, 6 and every 3 cycles thereafter up to radiographic progression (1 cycle = 28 days; baseline up to approximately 3 years)
measure: Overall Survival in All Participants
time frame: Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 3 years)
measure: Plasma Concentration of Ipatasertib
time frame: Day -7, 1, 15 of Cycle 1, Day 1, 15 of Cycle 2 (1 cyce = 28 days)
measure: Plasma Concentration of Ipatasertib's Metabolite, G-037720
time frame: Day -7, 1, 15 of Cycle 1, Day 1, 15 of Cycle 2 (1 cycle = 28 days)
measure: Plasma Concentration of Rucaparib
time frame: Day -7, 1, 15 of Cycle 1, Day 1, 15 of Cycle 2 (1 cycle = 28 days)
arm group label: Ipatasertib + Rucaparib
arm group type: Experimental
description: A Dose-Escalation Phase (Part 1) in participants with previously treated advanced breast cancer, ovarian cancer, or prostate cancer. There will be a 7-day run-in period with ipatasertib alone prior to Cycle 1, Day 1. After the completion of the ipatasertib run-in period, participants will begin Cycle 1, Day 1 of the ipatasertib and rucaparib combination treatment. Each cycle has 28 days. Participants will be split into 4 cohorts: Dose Level 1 group - 300 mg ipatasertib once daily (QD) + 400 mg rucaparib twice daily (BID), Dose Level 2a: 300 mg ipatasertib QD + 600 mg rucaparib BID, Dose Level 2b: 400 mg ipatasertib QD + 400 mg rucaparib BID, Dose Level 3: 400 mg ipatasertib QD + 600 mg rucaparib BID
arm group label: Part 2: Ipatasertib + Rucaparib
arm group type: Experimental
description: A Dose-Expansion Phase (Part 2) - The recommended dose identified in Part 1 (highest dose level of ipatasertib and rucaparib with an acceptable safety profile and less than one-third of participants experience a dose limiting toxicity) will be evaluated in participants with advanced prostate cancer who have had at least one line of prior therapy with second-generation androgen-receptor (AR)-targeted agents (e.g., abiraterone, enzalutamide, apalutamide).
intervention type: Drug
intervention name: Part 1, Dose Level 1 and Dose Level 2a: Ipatasertib
description: Ipatasertib, 300 mg administered PO QD for 7 days (run-in period prior to Cycle 1), then administer 300 mg PO QD for each cycle. Each cycle has 28 days. Doses are administered until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.
arm group label: Ipatasertib + Rucaparib
arm group label: Part 2: Ipatasertib + Rucaparib
other name: RO5532961, GDC-0068
intervention type: Drug
intervention name: Part 1, Dose level 2b and dose level 3: Ipatasertib
description: Ipatasertib, 400 mg administered PO QD for 7 days (run-in period prior to Cycle 1), then administer 400 mg PO QD for each cycle. One cycle has 28 days. Doses are administered until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.
arm group label: Ipatasertib + Rucaparib
arm group label: Part 2: Ipatasertib + Rucaparib
other name: RO5532961, GDC-0068
intervention type: Drug
intervention name: Part 1, Dose Level 1 and Dose Level 2b: Rucaparib
description: Rucaparib is administered 400 mg twice daily (BID) for each cycle. One cycle has 28 days. Doses are administered until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.
arm group label: Ipatasertib + Rucaparib
arm group label: Part 2: Ipatasertib + Rucaparib
other name: CO-338
intervention type: Drug
intervention name: Part 1, Dose Level 2a and Dose Level 3: Rucaparib
description: Rucaparib is administered 600 mg twice daily (BID) for each cycle. One cycle has 28 days. Doses are administered until disease progression, intolerable toxicity, elective withdrawal from the study, or study completion or termination.
arm group label: Ipatasertib + Rucaparib
arm group label: Part 2: Ipatasertib + Rucaparib
other name: CO-338
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Clinical Trials
role: Study Director
affiliation: Hoffmann-La Roche
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country: Australia
country: Italy
country: Korea, Republic of
country: Spain
country: United States
responsible party type: Sponsor
mesh term: Prostatic Neoplasms
mesh term: Ovarian Neoplasms
mesh term: Carcinoma, Ovarian Epithelial
mesh term: Rucaparib
mesh term: Ipatasertib
submitted: December 2, 2022