<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03822520</url>
  </required_header>
  <id_info>
    <org_study_id>2016-11-053</org_study_id>
    <nct_id>NCT03822520</nct_id>
  </id_info>
  <brief_title>Clinical Study to Evaluate Effect on QT/QTc Interval After Multiple Dose of Celecoxib</brief_title>
  <official_title>A Randomized, Open-label, Negative and Positive Control, Crossover Clinical Study to Evaluate Effect on QT/QTc Interval After Multiple Dose of Celecoxib in Healthy Adult Volunteers</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Samsung Medical Center</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Samsung Medical Center</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
    <is_us_export>No</is_us_export>
  </oversight_info>
  <brief_summary>
    <textblock>
      This study is conducted to evaluate effect on QT/QTc Interval after multiple dose of&#xD;
      celecoxib among healthy adult volunteers. It is randomized, open-label, negative and postive&#xD;
      control, and crossover study. Volunteers will be mainly checked up through ECG to find out&#xD;
      changes of QT/QTc interval during the study.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">June 30, 2017</start_date>
  <completion_date type="Actual">May 25, 2018</completion_date>
  <primary_completion_date type="Actual">May 25, 2018</primary_completion_date>
  <phase>Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Crossover Assignment</intervention_model>
    <primary_purpose>Other</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Change in QTc interval, read manually</measure>
    <time_frame>-1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day</time_frame>
    <description>which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Change in QTc , measured automatically</measure>
    <time_frame>-1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day</time_frame>
    <description>which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>ventricular rate, measured automatically</measure>
    <time_frame>-1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day</time_frame>
    <description>which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>PR duration, measured automatically</measure>
    <time_frame>-1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day</time_frame>
    <description>which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>RR duration, measured automatically</measure>
    <time_frame>-1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day</time_frame>
    <description>which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>QRS duration, measured automatically</measure>
    <time_frame>-1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day</time_frame>
    <description>which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Area under the curve within a dosing interval at steady state</measure>
    <time_frame>0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day6)</time_frame>
    <description>which is analyzed at the date of final administration of celecoxib</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Maximum concentration at steady state</measure>
    <time_frame>0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day6)</time_frame>
    <description>which is analyzed at the date of final administration of celecoxib</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Time to maximum concentration at steady state</measure>
    <time_frame>0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day6)</time_frame>
    <description>which is analyzed at the date of final administration of celecoxib</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Minimum concentration at steady state</measure>
    <time_frame>0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day6)</time_frame>
    <description>which is analyzed at the date of final administration of celecoxib</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Area under the concentration-time curve time zero to the time of the last quantifiable concentration</measure>
    <time_frame>0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)</time_frame>
    <description>which is analyzed at the date of final administration of moxifloxacin</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Maximum concentration</measure>
    <time_frame>0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)</time_frame>
    <description>which is analyzed at the date of final administration of moxifloxacin</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Time to maximum concentration</measure>
    <time_frame>0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)</time_frame>
    <description>which is analyzed at the date of final administration of moxifloxacin</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Half-life</measure>
    <time_frame>0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)</time_frame>
    <description>which is analyzed at the date of final administration of moxifloxacin</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The apparent clearance</measure>
    <time_frame>0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)</time_frame>
    <description>which is analyzed at the date of final administration of moxifloxacin</description>
  </secondary_outcome>
  <number_of_arms>4</number_of_arms>
  <enrollment type="Actual">28</enrollment>
  <condition>Qt Interval, Variation in</condition>
  <arm_group>
    <arm_group_label>Celecoxib, Moxifloxacin, Water in order</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Intervention Celecoxib: Celecoxib 400 mg capsule and water 150ml by mouth, daily for 6days&#xD;
Wash-out period (3~6 days)&#xD;
Intervention Moxifloxacin: Moxifloxacin 400 mg tablet and water 150ml by mouth, once for one day&#xD;
Wash-out period (3~6 days)&#xD;
Intervention Pure water: Water 150ml by mouth without any drug, once for one day</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Celecoxib, Water, Moxifloxacin in order</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Intervention Celecoxib: Celecoxib 400 mg capsule and water 150ml by mouth, daily for 6days&#xD;
Wash-out period (3~6 days)&#xD;
Intervention Pure water: Water 150ml by mouth without any drug, once for one day&#xD;
Wash-out period (3~6 days)&#xD;
Intervention Moxifloxacin: Moxifloxacin 400 mg tablet and water 150ml by mouth, once for one day</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Moxifloxacin, Water, Celecoxib in order</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Intervention Moxifloxacin: Moxifloxacin 400 mg tablet and water 150ml by mouth, once for one day&#xD;
Wash-out period (3~6 days)&#xD;
Intervention Pure water: Water 150ml by mouth without any drug, once for one day&#xD;
Wash-out period (3~6 days)&#xD;
Intervention Celecoxib: Celecoxib 400 mg capsule and water 150ml by mouth, daily for 6days</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Water, Moxifloxacin, Celecoxib in order</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Intervention Pure water: Water 150ml by mouth without any drug, once for one day&#xD;
Wash-out period (3~6 days)&#xD;
Intervention Moxifloxacin: Moxifloxacin 400 mg tablet and water 150ml by mouth, once for one day&#xD;
Wash-out period (3~6 days)&#xD;
Intervention Celecoxib: Celecoxib 400 mg capsule and water 150ml by mouth, daily for 6days</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Celecoxib</intervention_name>
    <description>Celecoxib 400mg capsule</description>
    <arm_group_label>Celecoxib, Moxifloxacin, Water in order</arm_group_label>
    <arm_group_label>Celecoxib, Water, Moxifloxacin in order</arm_group_label>
    <arm_group_label>Moxifloxacin, Water, Celecoxib in order</arm_group_label>
    <arm_group_label>Water, Moxifloxacin, Celecoxib in order</arm_group_label>
    <other_name>Celebrex</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Moxifloxacin</intervention_name>
    <description>Moxifloxacin 400mg tablet</description>
    <arm_group_label>Celecoxib, Moxifloxacin, Water in order</arm_group_label>
    <arm_group_label>Celecoxib, Water, Moxifloxacin in order</arm_group_label>
    <arm_group_label>Moxifloxacin, Water, Celecoxib in order</arm_group_label>
    <arm_group_label>Water, Moxifloxacin, Celecoxib in order</arm_group_label>
    <other_name>Avelox</other_name>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Water</intervention_name>
    <description>Pure water 150ml</description>
    <arm_group_label>Celecoxib, Moxifloxacin, Water in order</arm_group_label>
    <arm_group_label>Celecoxib, Water, Moxifloxacin in order</arm_group_label>
    <arm_group_label>Moxifloxacin, Water, Celecoxib in order</arm_group_label>
    <arm_group_label>Water, Moxifloxacin, Celecoxib in order</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Healthy adults between 19-year-old and 40-year-old during the screening day&#xD;
&#xD;
          -  BMI between 19 kg/m² and 30 kg/m² during the screening day&#xD;
&#xD;
          -  Be able to give an informed consent form after understanding for reasonable&#xD;
             explanation of clinical trial's purpose, contents and characteristics of clinical&#xD;
             drugs&#xD;
&#xD;
          -  Wiling to participate whole clinical trial periods&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Person who is able to clinically affect to the study through ECG result during the&#xD;
             screening day&#xD;
&#xD;
          -  Has critical issue for Torsade de points from heart failure, hypopotassemia,&#xD;
             arrhythmia etc., or family history for long QT syndrome, sudden cardiac death.&#xD;
&#xD;
          -  Was suffered, or is suffering from like liver, kidney, digestive system, circulatory&#xD;
             system, respiratory system, endocrine system(except diabetes), musculoskeletal,&#xD;
             neuropsychiatry, or hemato-oncology etc., which is able to effect on clinical study&#xD;
&#xD;
          -  Has allergy which is required the treatment or hypersensitive from drugs such as&#xD;
             aspirin, anti-biotics, anti-depressants, etc.&#xD;
&#xD;
          -  Was administered any drug of other clinical study within 90 days from the&#xD;
             randomization day.&#xD;
&#xD;
          -  Donated whole blood within 60days or apheresis within 30 days from the randomization&#xD;
             day.&#xD;
&#xD;
          -  Took any medicine or oriental medicine within 2 weeks, or general pharmaceuticals&#xD;
             within 7 days from the randomization day. (For general pharmaceuticals circumstances,&#xD;
             PI could decide whether he/she is suitable for the study)&#xD;
&#xD;
          -  No intention to take contraceptive which is approved as clinical way, or is planning&#xD;
             on giving their sperm or egg during the whole clinical trial.&#xD;
&#xD;
          -  Average alcohol consumption per week: &gt;140g&#xD;
&#xD;
          -  Average smoking per day: &gt;20&#xD;
&#xD;
          -  Average grapefruit juice consumption per day: &gt;4 glasses&#xD;
&#xD;
          -  systolic blood pressure &lt;100 mmHg or &gt;150 mmHg, or diastolic pressure &lt;70 mmHg or&#xD;
             &gt;100mmHg&#xD;
&#xD;
          -  Over 2 times from the maximum reference interval of AST and ALT levels in the blood.&#xD;
&#xD;
          -  eGFR by MDRD from creatinine in the blood is less than 30 mL/min.&#xD;
&#xD;
          -  doesn't show negative reaction from HIV Test, B hepatitis test, or C hepatitis test&#xD;
&#xD;
          -  For woman, doesn't show negative reaction from pregnancy test&#xD;
&#xD;
          -  PI decides the person is not suitable to participate the clinical study with other&#xD;
             reasons.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>19 Years</minimum_age>
    <maximum_age>40 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>JUNGRYUL KIM, MD, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Samsung Medical Center</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Samsung Medical Center</name>
      <address>
        <city>Seoul</city>
        <country>Korea, Republic of</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Korea, Republic of</country>
  </location_countries>
  <verification_date>January 2019</verification_date>
  <study_first_submitted>November 8, 2018</study_first_submitted>
  <study_first_submitted_qc>January 29, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">January 30, 2019</study_first_posted>
  <last_update_submitted>January 29, 2019</last_update_submitted>
  <last_update_submitted_qc>January 29, 2019</last_update_submitted_qc>
  <last_update_posted type="Actual">January 30, 2019</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Samsung Medical Center</investigator_affiliation>
    <investigator_full_name>Jung-Ryul Kim</investigator_full_name>
    <investigator_title>Professor</investigator_title>
  </responsible_party>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Moxifloxacin</mesh_term>
    <mesh_term>Celecoxib</mesh_term>
  </intervention_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03822520
org study id: 2016-11-053
nct id: NCT03822520
lead sponsor: 
is fda regulated drug: No
is fda regulated device: No
is us export: No
This study is conducted to evaluate effect on QT/QTc Interval after multiple dose of
      celecoxib among healthy adult volunteers. It is randomized, open-label, negative and postive
      control, and crossover study. Volunteers will be mainly checked up through ECG to find out
      changes of QT/QTc interval during the study.
allocation: Randomized
intervention model: Crossover Assignment
primary purpose: Other
masking: None (Open Label)
measure: Change in QTc interval, read manually
time frame: -1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day
description: which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.
measure: Change in QTc , measured automatically
time frame: -1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day
description: which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.
measure: ventricular rate, measured automatically
time frame: -1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day
description: which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.
measure: PR duration, measured automatically
time frame: -1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day
description: which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.
measure: RR duration, measured automatically
time frame: -1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day
description: which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.
measure: QRS duration, measured automatically
time frame: -1 hour, -40 minutes, -20 minutes pre-dose at initial administration day and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at last administration day
description: which is analyzed at the date of initial and final administration of celecoxib, moxifloxacin, water toward healthy volunteers.
measure: Area under the curve within a dosing interval at steady state
time frame: 0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day6)
description: which is analyzed at the date of final administration of celecoxib
measure: Maximum concentration at steady state
time frame: 0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day6)
description: which is analyzed at the date of final administration of celecoxib
measure: Time to maximum concentration at steady state
time frame: 0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day6)
description: which is analyzed at the date of final administration of celecoxib
measure: Minimum concentration at steady state
time frame: 0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day6)
description: which is analyzed at the date of final administration of celecoxib
measure: Area under the concentration-time curve time zero to the time of the last quantifiable concentration
time frame: 0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)
description: which is analyzed at the date of final administration of moxifloxacin
measure: Maximum concentration
time frame: 0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)
description: which is analyzed at the date of final administration of moxifloxacin
measure: Time to maximum concentration
time frame: 0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)
description: which is analyzed at the date of final administration of moxifloxacin
measure: Half-life
time frame: 0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)
description: which is analyzed at the date of final administration of moxifloxacin
measure: The apparent clearance
time frame: 0 hour pre-dose and 1 hour, 2 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours, 16 hours, 24 hours post-dose at final administration day(Day1)
description: which is analyzed at the date of final administration of moxifloxacin
arm group label: Celecoxib, Moxifloxacin, Water in order
arm group type: Experimental
description: Intervention Celecoxib: Celecoxib 400 mg capsule and water 150ml by mouth, daily for 6days
Wash-out period (3~6 days)
Intervention Moxifloxacin: Moxifloxacin 400 mg tablet and water 150ml by mouth, once for one day
Wash-out period (3~6 days)
Intervention Pure water: Water 150ml by mouth without any drug, once for one day
arm group label: Celecoxib, Water, Moxifloxacin in order
arm group type: Experimental
description: Intervention Celecoxib: Celecoxib 400 mg capsule and water 150ml by mouth, daily for 6days
Wash-out period (3~6 days)
Intervention Pure water: Water 150ml by mouth without any drug, once for one day
Wash-out period (3~6 days)
Intervention Moxifloxacin: Moxifloxacin 400 mg tablet and water 150ml by mouth, once for one day
arm group label: Moxifloxacin, Water, Celecoxib in order
arm group type: Experimental
description: Intervention Moxifloxacin: Moxifloxacin 400 mg tablet and water 150ml by mouth, once for one day
Wash-out period (3~6 days)
Intervention Pure water: Water 150ml by mouth without any drug, once for one day
Wash-out period (3~6 days)
Intervention Celecoxib: Celecoxib 400 mg capsule and water 150ml by mouth, daily for 6days
arm group label: Water, Moxifloxacin, Celecoxib in order
arm group type: Experimental
description: Intervention Pure water: Water 150ml by mouth without any drug, once for one day
Wash-out period (3~6 days)
Intervention Moxifloxacin: Moxifloxacin 400 mg tablet and water 150ml by mouth, once for one day
Wash-out period (3~6 days)
Intervention Celecoxib: Celecoxib 400 mg capsule and water 150ml by mouth, daily for 6days
intervention type: Drug
intervention name: Celecoxib
description: Celecoxib 400mg capsule
arm group label: Celecoxib, Moxifloxacin, Water in order
arm group label: Celecoxib, Water, Moxifloxacin in order
arm group label: Moxifloxacin, Water, Celecoxib in order
arm group label: Water, Moxifloxacin, Celecoxib in order
other name: Celebrex
intervention type: Drug
intervention name: Moxifloxacin
description: Moxifloxacin 400mg tablet
arm group label: Celecoxib, Moxifloxacin, Water in order
arm group label: Celecoxib, Water, Moxifloxacin in order
arm group label: Moxifloxacin, Water, Celecoxib in order
arm group label: Water, Moxifloxacin, Celecoxib in order
other name: Avelox
intervention type: Other
intervention name: Water
description: Pure water 150ml
arm group label: Celecoxib, Moxifloxacin, Water in order
arm group label: Celecoxib, Water, Moxifloxacin in order
arm group label: Moxifloxacin, Water, Celecoxib in order
arm group label: Water, Moxifloxacin, Celecoxib in order
criteria: 
gender: All
minimum age: 19 Years
maximum age: 40 Years
healthy volunteers: Accepts Healthy Volunteers
last name: JUNGRYUL KIM, MD, PhD
role: Principal Investigator
affiliation: Samsung Medical Center
facility: 
country: Korea, Republic of
responsible party type: Principal Investigator
investigator affiliation: Samsung Medical Center
investigator full name: Jung-Ryul Kim
investigator title: Professor
mesh term: Moxifloxacin
mesh term: Celecoxib