<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03807063</url>
  </required_header>
  <id_info>
    <org_study_id>RG1004457</org_study_id>
    <secondary_id>NCI-2019-00042</secondary_id>
    <secondary_id>9739</secondary_id>
    <secondary_id>P30CA015704</secondary_id>
    <nct_id>NCT03807063</nct_id>
  </id_info>
  <brief_title>Rivogenlecleucel Donor Lymphocyte Immunotherapy in Treating Patients With Recurrent Blood Cancers After Stem Cell Transplant</brief_title>
  <official_title>Phase I Trial With &quot;Off-The-Shelf&quot; Third-Party BPX-501 Donor Lymphocyte Immunotherapy to Treat Persistence or Relapse of Hematologic Malignancies After Allogeneic Stem Cell Transplantation</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Fred Hutchinson Cancer Center</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>National Cancer Institute (NCI)</agency>
      <agency_class>NIH</agency_class>
    </collaborator>
    <collaborator>
      <agency>Bellicum Pharmaceuticals</agency>
      <agency_class>Industry</agency_class>
    </collaborator>
  </sponsors>
  <source>Fred Hutchinson Cancer Center</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>Yes</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This phase I trial studies the side effects and best dose of rivogenlecleucel, and how well&#xD;
      it works, in treating patients with blood cancer that has come back (recurrent) after stem&#xD;
      cell transplant. Donor T-cell therapy (rivogenlecleucel) may help control transplant-related&#xD;
      infections after stem cell transplant.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      This is a dose-escalation study of rivogenlecleucel.&#xD;
&#xD;
      Each subject may receive up to 3 doses of rivogenlecleucel intravenously (IV), at intervals&#xD;
      of no less than 28 days. Subjects meeting protocol-specified severity criteria for acute&#xD;
      GVHD, chronic GVHD, cytokine release syndrome (CRS), prolonged aplasia, or encephalopathy&#xD;
      will be treated with rimiducid infusion(s).&#xD;
&#xD;
      After completion of study treatment, patients are followed up every 6 months for 5 years and&#xD;
      then annually for 10 years.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Withdrawn</overall_status>
  <why_stopped>
    Insufficient funding&#xD;
  </why_stopped>
  <start_date type="Actual">January 2, 2020</start_date>
  <completion_date type="Anticipated">December 31, 2021</completion_date>
  <primary_completion_date type="Anticipated">December 31, 2020</primary_completion_date>
  <phase>Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>N/A</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Global incidence of grade II-IV acute graft versus host disease (GVHD) requiring rimiducid treatment</measure>
    <time_frame>1 year after last rivogenlecleucel infusion</time_frame>
    <description>Will be reported, and 95% confidence intervals will be calculated. The global incidence of grade II-IV acute GVHD (requiring rimiducid or not) will also be reported.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Dose-limiting toxicity (DLT) of BPX-501</measure>
    <time_frame>56 days after last rivogenlecleucel or rimiducid infusion (whichever is later)</time_frame>
    <description>Will be reported, and 95% confidence intervals will be calculated. The specific DLTs will be reported descriptively.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Time to neutrophil and platelet recovery</measure>
    <time_frame>1 year</time_frame>
    <description>Will be reported with cumulative incidence curves (with death as a competing risk), for all donor lymphocyte infusions (DLIs) combined and for each separate dose level.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Time to grade II-IV acute GVHD</measure>
    <time_frame>1 year</time_frame>
    <description>Will be reported with cumulative incidence curves (with death as a competing risk), for all DLIs combined and for each separate dose level.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Disease response</measure>
    <time_frame>1 year</time_frame>
    <description>Descriptive, due to the expected heterogeneity of enrolled subjects</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Survival</measure>
    <time_frame>1 year</time_frame>
    <description>Descriptive, due to the expected heterogeneity of enrolled subjects</description>
  </secondary_outcome>
  <number_of_arms>1</number_of_arms>
  <enrollment type="Actual">0</enrollment>
  <condition>Acute Bilineal Leukemia</condition>
  <condition>Myelodysplastic/Myeloproliferative Neoplasm</condition>
  <condition>Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable</condition>
  <condition>Myeloproliferative Neoplasm</condition>
  <condition>Recurrent Acute Biphenotypic Leukemia</condition>
  <condition>Recurrent Acute Lymphoblastic Leukemia</condition>
  <condition>Recurrent Acute Myeloid Leukemia</condition>
  <condition>Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm</condition>
  <condition>Recurrent Chronic Lymphocytic Leukemia</condition>
  <condition>Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive</condition>
  <condition>Recurrent Chronic Myelomonocytic Leukemia</condition>
  <condition>Recurrent Myelodysplastic Syndrome</condition>
  <arm_group>
    <arm_group_label>Treatment (rivogenlecleucel)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Each subject may receive up to 3 IV infusions of rivogenlecleucel at intervals no less than 28 days apart. Subjects who meet protocol-specified severity criteria for acute GVHD, chronic GVHD, cytokine release syndrome (CRS), prolonged aplasia or encephalopathy will be treated with rimiducid infusion(s).</description>
  </arm_group>
  <intervention>
    <intervention_type>Biological</intervention_type>
    <intervention_name>Rivogenlecleucel</intervention_name>
    <description>Given IV</description>
    <arm_group_label>Treatment (rivogenlecleucel)</arm_group_label>
    <other_name>Allogeneic T-Lymphocytes BPX-501</other_name>
    <other_name>BPX-501</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Rimiducid</intervention_name>
    <description>Given IV</description>
    <arm_group_label>Treatment (rivogenlecleucel)</arm_group_label>
    <other_name>AP1903</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Original HCT donor: The most recent transplant was from a related or unrelated donor&#xD;
             with an allele-level match to the recipient at HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1&#xD;
             (10/10) or with a single antigen or allele mismatch (9/10), or with one or two&#xD;
             umbilical cord blood units that are individually antigen-level matched to the&#xD;
             recipient in at least 4 of 6 HLA loci (HLA-A, -B, -DRB1).&#xD;
&#xD;
          -  Graft source: The most recent transplant (and any previous allotransplant) was from&#xD;
             mobilized peripheral blood stem cells and/or bone marrow and/or umbilical cord blood.&#xD;
&#xD;
          -  Transplant number: The relapse occurred after a 1st, 2nd or 3rd allogeneic HCT.&#xD;
&#xD;
          -  Diseases: The subject relapsed or progressed with the same or related disease which&#xD;
             prompted the previous allogeneic HCT.&#xD;
&#xD;
               -  Leukemia (acute myeloid leukemia [AML], acute lymphoblastic leukemia [ALL],&#xD;
                  chronic myelogenous leukemia [CML], chronic lymphocytic leukemia [CLL], chronic&#xD;
                  myelomonocytic leukemia [CMML], blastic plasmacytoid dendritic cell,&#xD;
                  biphenotypic, bilineage)&#xD;
&#xD;
               -  Myelodysplasia&#xD;
&#xD;
               -  Myeloproliferative neoplasm&#xD;
&#xD;
               -  Myelodysplasia/myeloproliferative neoplasms (including &quot;unclassified&quot;).&#xD;
&#xD;
          -  For subjects with persistent or relapsed acute B-cell lymphoblastic leukemia, the&#xD;
             subject must have previously received a chimeric antigen receptor (CAR) T cell product&#xD;
             and blinatumomab at any point (not necessarily to treat the current relapse or after&#xD;
             the current allogeneic transplant), unless the subject is ineligible for a&#xD;
             commercially-available CAR T cell product or blinatumomab or declines those&#xD;
             treatments.&#xD;
&#xD;
          -  Relapse stage: The disease stage may be ascertained any time after engraftment of the&#xD;
             original donor cells, where engraftment is defined as the first of 3 consecutive days&#xD;
             of absolute neutrophil count &gt;= 500/uL unsupported by granulocyte-colony stimulating&#xD;
             factor (G-CSF) within the preceding 5 days. (Note that eligibility for the protocol&#xD;
             does not require an ANC &gt; 500/uL at the time of enrollment.) Subjects with any of the&#xD;
             following disease stages are eligible for this protocol:&#xD;
&#xD;
               -  Morphologic disease persistence or relapse (defined as &gt;= 5% bone marrow blasts&#xD;
                  in a bone marrow aspirate or biopsy, and/or the presence of circulating blasts&#xD;
                  detected by automated differential or review of the peripheral blood film and&#xD;
                  confirmed to be malignant, and/or &gt;= 5% bone marrow blasts with aberrant&#xD;
                  immunophenotype consistent with malignancy detected by flow cytometry of blood or&#xD;
                  marrow)&#xD;
&#xD;
               -  Extramedullary disease persistence or relapse (e.g., granulocytic sarcoma,&#xD;
                  leukemia cutis)&#xD;
&#xD;
               -  A new hematologic malignancy related to the prior transplant indication (such as&#xD;
                  AML arising from myelodysplastic syndrome [MDS] or ALL arising from mixed lineage&#xD;
                  leukemia [MLL]-rearranged AML) as per above&#xD;
&#xD;
          -  Subject may have received prior DLI and/or prior genetically-modified DLI such as&#xD;
             CAR-T cells and/or prior chemotherapy other than purine analogues to treat minimal&#xD;
             residual disease (MRD) or morphologic/clinical relapse or disease persistence but must&#xD;
             have had relapse as defined at some point after the most recent HCT to be enrolled on&#xD;
             this study.&#xD;
&#xD;
          -  Adequate HCT donor chimerism as indicated by original-donor T cell chimerism (from the&#xD;
             most recent HCT) in peripheral blood &gt;= 50%. In the case of double umbilical cord&#xD;
             transplant, one of the cord donors should constitute &gt;= 50% of the peripheral blood T&#xD;
             cells.&#xD;
&#xD;
          -  For subjects who received genetically-modified T cells such as CAR-T cells or&#xD;
             antigen-specific T-cell receptor (TCR) T cells, the non-engineered, polyclonal T cells&#xD;
             must constitute at least 50% of total peripheral blood T cells.&#xD;
&#xD;
          -  Performance status: Karnofsky or Lansky performance status (PS) &gt;= 80% or Eastern&#xD;
             Cooperative Oncology Group (ECOG) PS 0-1.&#xD;
&#xD;
          -  Capable of giving informed consent, if the subject is 18 years of age or older. A&#xD;
             parent or legal representative will be asked to consent for patients young than 18&#xD;
             years old.&#xD;
&#xD;
          -  DONOR: The donor must be available to undergo apheresis at the Seattle Cancer Care&#xD;
             Alliance, South Lake Union site or at Bloodworks Northwest.&#xD;
&#xD;
          -  DONOR: The donor must be suitable for medical reasons to donate according to&#xD;
             institutional Standard Practice Guidelines and National Marrow Donor Program (NMDP)&#xD;
             guidelines, including the absence of transmissible infections (hepatitis A, B, HIV,&#xD;
             HTLV I/II, syphilis, West Nile virus [WNV] and Chagas disease).&#xD;
&#xD;
          -  DONOR: The donor must not be homozygous to the recipient at an HLA allele that is&#xD;
             common to recipient and donor. (Homozygosity at antigenic resolution is permitted.)&#xD;
             Therefore, people who are homozygous at any HLA allele will be excluded.&#xD;
&#xD;
          -  DONOR: The donor may not knowingly be related to a subject on this study by blood&#xD;
             (e.g., sibling, parent, child, cousin). This is to prevent &quot;coercive recruitment&quot; of&#xD;
             donors.&#xD;
&#xD;
          -  DONOR: The donor must be 18-50 years old.&#xD;
&#xD;
          -  DONOR: Capable of giving informed consent.&#xD;
&#xD;
          -  DONOR: Not pregnant or breastfeeding at the time of apheresis.&#xD;
&#xD;
          -  DONOR: Not on any prescription medications other than birth control pills or vitamins.&#xD;
&#xD;
          -  DONOR: The donor must be cytomegalovirus (CMV) seronegative at the time of screening.&#xD;
             For the product to be banked, the CMV polymerase chain reaction (PCR) done on the day&#xD;
             of apheresis must be negative.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Subjects who currently have &gt;= grade 1 acute GVHD or any chronic GVHD manifestation&#xD;
             beyond pre-existing ocular or oral sicca or pre-existing sclerosis.&#xD;
&#xD;
          -  Subjects with oral or ocular sicca attributable to prior chronic GVHD should be&#xD;
             excluded if there are other signs of active GVHD such as eosinophilia not explained by&#xD;
             other causes (e.g. recurrent malignancy, medication).&#xD;
&#xD;
          -  Inability to have their dose of corticosteroids tapered to =&lt; 0.25 mg/kg/day&#xD;
             prednisone-equivalent for a minimum of 7 days prior to BPX-501 cell infusion. This&#xD;
             determination will be made by the subject's treating physician (who is managing the&#xD;
             subject's GVHD), documented in a clinical note, and verified by the protocol principal&#xD;
             investigator (Pl).&#xD;
&#xD;
          -  Inability to stop all non-steroid immunosuppressive drugs (excepting beclomethasone,&#xD;
             budesonide, topical skin corticosteroids, topical tacrolimus, Restasis eye drops, or&#xD;
             low doses of glucocorticoids and/or mineralocorticoids given for adrenal&#xD;
             insufficiency) for at least 2 weeks without development of grade 1 or greater acute&#xD;
             GVHD according to the modified Keystone and NIH GVHD Morbidity Scales.&#xD;
&#xD;
          -  The use of purine analogue chemotherapy (including pentostatin), alemtuzumab,&#xD;
             anti-thymocyte globulin, anti-lymphocyte globulin, total body irradiation, and total&#xD;
             lymphoid irradiation at any time after infusion of the index HCT graft. All other&#xD;
             debulking protocols and patients who received any form of ex-vivo T-cell depleted&#xD;
             graft should be cleared by the protocol PI before confirming subject eligibility for&#xD;
             this trial.&#xD;
&#xD;
          -  Central nervous system (CNS) leukemia (including leukemia detectable in the&#xD;
             cerebrospinal fluid and/or solid chloromas and/or leptomeningeal leukemia) that has&#xD;
             not cleared with radiation, intrathecal or systemic therapy.&#xD;
&#xD;
          -  Inadequate cardiac function defined by left ventricular ejection fraction (LVEF) &lt;&#xD;
             40%.&#xD;
&#xD;
          -  Inadequate pulmonary function defined by any one of the following: forced expiratory&#xD;
             volume in one second (FEV1), forced vital capacity (FVC), or corrected diffusion&#xD;
             capacity of the lung for carbon monoxide (DLCO) &lt; 40% predicted, or peripheral&#xD;
             capillary oxygen saturation (SpO2) &lt; 92% on room air.&#xD;
&#xD;
          -  Direct bilirubin &gt; 3 x upper limit of normal.&#xD;
&#xD;
          -  Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) &gt; 5 X upper limit of&#xD;
             normal.&#xD;
&#xD;
          -  Creatinine &gt; 2 X upper limit of normal for age or on dialysis.&#xD;
&#xD;
          -  Concurrent active malignancy other than the malignancy under treatment with BPX-501.&#xD;
&#xD;
          -  Uncontrolled infection, including no invasive fungal infection during the acute&#xD;
             antifungal treatment phase (secondary prophylaxis for fungal infection is permitted)&#xD;
             and no viral respiratory tract infection that has not cleared as evidenced by a&#xD;
             negative nasopharyngeal aspirate or nasopharyngeal swab.&#xD;
&#xD;
          -  Positive for human immunodeficiency virus (HIV), chronic hepatitis B, chronic&#xD;
             hepatitis C, or human T-lymphotropic virus (HTLV) pre-transplant (To continue on&#xD;
             study, this testing also needs to be confirmed negative within 30 days pre-DLI).&#xD;
&#xD;
          -  Fertile men and women unwilling to use contraceptives before, during, and for 4 months&#xD;
             after BPX-501 infusion.&#xD;
&#xD;
          -  Pregnancy: For females of childbearing potential, a pregnancy test is required at&#xD;
             enrollment and must be confirmed negative within 7 days before BPX-501 T cell&#xD;
             infusion.&#xD;
&#xD;
          -  Medical or psychological conditions present within 30 days prior to enrollment that&#xD;
             would make the subject unsuitable for cell therapy or for research trial participation&#xD;
             at the discretion of the PI.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>12 Months</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Elizabeth Krakow</last_name>
    <role>Principal Investigator</role>
    <affiliation>Fred Hutch/University of Washington Cancer Consortium</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Fred Hutch/University of Washington Cancer Consortium</name>
      <address>
        <city>Seattle</city>
        <state>Washington</state>
        <zip>98109</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <verification_date>August 2020</verification_date>
  <study_first_submitted>January 14, 2019</study_first_submitted>
  <study_first_submitted_qc>January 15, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">January 16, 2019</study_first_posted>
  <last_update_submitted>August 12, 2020</last_update_submitted>
  <last_update_submitted_qc>August 12, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">August 14, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Leukemia</mesh_term>
    <mesh_term>Neoplasms</mesh_term>
    <mesh_term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</mesh_term>
    <mesh_term>Leukemia, Lymphocytic, Chronic, B-Cell</mesh_term>
    <mesh_term>Leukemia, Myeloid</mesh_term>
    <mesh_term>Leukemia, Myelogenous, Chronic, BCR-ABL Positive</mesh_term>
    <mesh_term>Leukemia, Myelomonocytic, Chronic</mesh_term>
    <mesh_term>Leukemia, Myelomonocytic, Juvenile</mesh_term>
    <mesh_term>Leukemia, Biphenotypic, Acute</mesh_term>
    <mesh_term>Myelodysplastic Syndromes</mesh_term>
    <mesh_term>Myeloproliferative Disorders</mesh_term>
    <mesh_term>Myelodysplastic-Myeloproliferative Diseases</mesh_term>
    <mesh_term>Recurrence</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03807063
org study id: RG1004457
secondary id: NCI-2019-00042
secondary id: 9739
secondary id: P30CA015704
nct id: NCT03807063
lead sponsor: 
collaborator: 
collaborator: 
has dmc: Yes
is fda regulated drug: Yes
is fda regulated device: No
This phase I trial studies the side effects and best dose of rivogenlecleucel, and how well
      it works, in treating patients with blood cancer that has come back (recurrent) after stem
      cell transplant. Donor T-cell therapy (rivogenlecleucel) may help control transplant-related
      infections after stem cell transplant.
This is a dose-escalation study of rivogenlecleucel.

      Each subject may receive up to 3 doses of rivogenlecleucel intravenously (IV), at intervals
      of no less than 28 days. Subjects meeting protocol-specified severity criteria for acute
      GVHD, chronic GVHD, cytokine release syndrome (CRS), prolonged aplasia, or encephalopathy
      will be treated with rimiducid infusion(s).

      After completion of study treatment, patients are followed up every 6 months for 5 years and
      then annually for 10 years.
allocation: N/A
intervention model: Single Group Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Global incidence of grade II-IV acute graft versus host disease (GVHD) requiring rimiducid treatment
time frame: 1 year after last rivogenlecleucel infusion
description: Will be reported, and 95% confidence intervals will be calculated. The global incidence of grade II-IV acute GVHD (requiring rimiducid or not) will also be reported.
measure: Dose-limiting toxicity (DLT) of BPX-501
time frame: 56 days after last rivogenlecleucel or rimiducid infusion (whichever is later)
description: Will be reported, and 95% confidence intervals will be calculated. The specific DLTs will be reported descriptively.
measure: Time to neutrophil and platelet recovery
time frame: 1 year
description: Will be reported with cumulative incidence curves (with death as a competing risk), for all donor lymphocyte infusions (DLIs) combined and for each separate dose level.
measure: Time to grade II-IV acute GVHD
time frame: 1 year
description: Will be reported with cumulative incidence curves (with death as a competing risk), for all DLIs combined and for each separate dose level.
measure: Disease response
time frame: 1 year
description: Descriptive, due to the expected heterogeneity of enrolled subjects
measure: Survival
time frame: 1 year
description: Descriptive, due to the expected heterogeneity of enrolled subjects
arm group label: Treatment (rivogenlecleucel)
arm group type: Experimental
description: Each subject may receive up to 3 IV infusions of rivogenlecleucel at intervals no less than 28 days apart. Subjects who meet protocol-specified severity criteria for acute GVHD, chronic GVHD, cytokine release syndrome (CRS), prolonged aplasia or encephalopathy will be treated with rimiducid infusion(s).
intervention type: Biological
intervention name: Rivogenlecleucel
description: Given IV
arm group label: Treatment (rivogenlecleucel)
other name: Allogeneic T-Lymphocytes BPX-501
other name: BPX-501
intervention type: Drug
intervention name: Rimiducid
description: Given IV
arm group label: Treatment (rivogenlecleucel)
other name: AP1903
criteria: 
gender: All
minimum age: 12 Months
maximum age: N/A
healthy volunteers: No
last name: Elizabeth Krakow
role: Principal Investigator
affiliation: Fred Hutch/University of Washington Cancer Consortium
facility: 
country: United States
responsible party type: Sponsor
mesh term: Leukemia
mesh term: Neoplasms
mesh term: Precursor Cell Lymphoblastic Leukemia-Lymphoma
mesh term: Leukemia, Lymphocytic, Chronic, B-Cell
mesh term: Leukemia, Myeloid
mesh term: Leukemia, Myelogenous, Chronic, BCR-ABL Positive
mesh term: Leukemia, Myelomonocytic, Chronic
mesh term: Leukemia, Myelomonocytic, Juvenile
mesh term: Leukemia, Biphenotypic, Acute
mesh term: Myelodysplastic Syndromes
mesh term: Myeloproliferative Disorders
mesh term: Myelodysplastic-Myeloproliferative Diseases
mesh term: Recurrence
sharing ipd: No