<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03774940</url>
  </required_header>
  <id_info>
    <org_study_id>2013/198</org_study_id>
    <nct_id>NCT03774940</nct_id>
  </id_info>
  <brief_title>Blood Parameters as a Predictor of Fever After Percutaneous Nephrolithotomy</brief_title>
  <official_title>Neutrophil and Lymphocyte Counts and the Neutrophil-to-lymphocyte Ratio as a Predictor of Fever Following Percutaneous Nephrolithotomy in Patients Without Risk Factors</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>TC Erciyes University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>TC Erciyes University</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      To investigate the relationship between neutrophil count, lymphocyte count,&#xD;
      neutrophil-to-lymphocyte count ratio (NLR), and postoperative fever in patients undergoing&#xD;
      percutaneous nephrolithotomy (PNL).&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Percutaneous nephrolithotomy (PNL) is a minimally invasive treatment commonly used for renal&#xD;
      calculi. However, the prevalence of postoperative fever is reported to be 16.7%-35%, even&#xD;
      with appropriate prophylactic antibiotic therapy and a sterile urine culture. The most&#xD;
      probable causes are urinary extravasation and bacteremia. Although it is important to&#xD;
      postoperatively isolate the causative bacteria, bacterial isolation may not always be&#xD;
      possible, and urinary and blood cultures may prove negative. In addition, establishing the&#xD;
      etiology of fever could be time-consuming and the techniques involved may generate&#xD;
      pseudo-negative results owing to several factors, especially the antibiotics used&#xD;
      prophylactically. This can result in a prolonged hospital stay and increased the cost of&#xD;
      patient care.&#xD;
&#xD;
      The most commonly used parameters for the early diagnosis of bacterial infections, despite&#xD;
      their limited use, are C-reactive protein, white blood cell count, and neutrophil count .&#xD;
      Superior parameters include procalcitonin, pro-adrenomedullin, interleukin (IL)-6, and IL-8,&#xD;
      but their use is limited by their lack of availability in some centers and their higher&#xD;
      costs. Recently, the ratio of neutrophil count to lymphocyte count (NLR) has been proposed as&#xD;
      an effective, simple, and useful biomarker for the early diagnosis of bacterial infections.&#xD;
      However, these tests are used after the emergence of fever. As yet, no single parameter has&#xD;
      been proposed for predicting postoperative fever in the absence of preoperative factors known&#xD;
      to cause fever.&#xD;
&#xD;
      The aim of this study was to investigate whether neutrophil count, lymphocyte count, and NLR&#xD;
      obtained from routine preoperative blood tests could be used in predicting fever following&#xD;
      PNL in patients with no risk factors for infection.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">January 1, 2005</start_date>
  <completion_date type="Actual">January 31, 2014</completion_date>
  <primary_completion_date type="Actual">December 1, 2013</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Non-Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Prevention</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>White blood cell count</measure>
    <time_frame>preoperative</time_frame>
    <description>white blood cell count</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Neutrophil count</measure>
    <time_frame>preoperative</time_frame>
    <description>neutrophil count</description>
  </primary_outcome>
  <primary_outcome>
    <measure>N/L</measure>
    <time_frame>preoperative</time_frame>
    <description>ratio of neutrophil count to lymphocyte count</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Lymphocyte count</measure>
    <time_frame>preoperative</time_frame>
    <description>Lymphocyte count</description>
  </primary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">519</enrollment>
  <condition>Urinary Tract Infection Bacterial</condition>
  <condition>Nephrolithiasis</condition>
  <arm_group>
    <arm_group_label>fever</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>patients that have fever after PNL</description>
  </arm_group>
  <arm_group>
    <arm_group_label>No fever</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Patients without fever after PNL</description>
  </arm_group>
  <intervention>
    <intervention_type>Diagnostic Test</intervention_type>
    <intervention_name>peripheric blood count</intervention_name>
    <description>preoperative peripheric blood count</description>
    <arm_group_label>No fever</arm_group_label>
    <arm_group_label>fever</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  underwent PNL operation&#xD;
&#xD;
          -  preoperative white blood cell count between 4,000 and 12,000/µL&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  preoperative urinary system obstruction&#xD;
&#xD;
          -  proliferation in preoperative and/or postoperative urine culture&#xD;
&#xD;
          -  preoperative and/or postoperative blood transfusions&#xD;
&#xD;
          -  a preoperative urinary diversion and/or intervention&#xD;
&#xD;
          -  the presence of a postoperative residual stone&#xD;
&#xD;
          -  the presence of malignancy,&#xD;
&#xD;
          -  the presence of a hematologic disease.&#xD;
&#xD;
          -  patients with postoperative complications graded as Clavien 2 and above&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Abdullah Demirtas, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Erciyes University Faculty of Medicine</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Erciyes University Faculty of Medicine Department of Urology</name>
      <address>
        <city>Kayseri</city>
        <zip>38039</zip>
        <country>Turkey</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Turkey</country>
  </location_countries>
  <reference>
    <citation>Draga RO, Kok ET, Sorel MR, Bosch RJ, Lock TM. Percutaneous nephrolithotomy: factors associated with fever after the first postoperative day and systemic inflammatory response syndrome. J Endourol. 2009 Jun;23(6):921-7. doi: 10.1089/end.2009.0041.</citation>
    <PMID>19473071</PMID>
  </reference>
  <reference>
    <citation>Cadeddu JA, Chen R, Bishoff J, Micali S, Kumar A, Moore RG, Kavoussi LR. Clinical significance of fever after percutaneous nephrolithotomy. Urology. 1998 Jul;52(1):48-50. doi: 10.1016/s0090-4295(98)00146-0.</citation>
    <PMID>9671869</PMID>
  </reference>
  <reference>
    <citation>Sharifi Aghdas F, Akhavizadegan H, Aryanpoor A, Inanloo H, Karbakhsh M. Fever after percutaneous nephrolithotomy: contributing factors. Surg Infect (Larchmt). 2006 Aug;7(4):367-71. doi: 10.1089/sur.2006.7.367.</citation>
    <PMID>16978080</PMID>
  </reference>
  <reference>
    <citation>Nuutila J, Lilius EM. Distinction between bacterial and viral infections. Curr Opin Infect Dis. 2007 Jun;20(3):304-10. doi: 10.1097/QCO.0b013e3280964db4.</citation>
    <PMID>17471042</PMID>
  </reference>
  <reference>
    <citation>Lutfiyya MN, Henley E, Chang LF, Reyburn SW. Diagnosis and treatment of community-acquired pneumonia. Am Fam Physician. 2006 Feb 1;73(3):442-50.</citation>
    <PMID>16477891</PMID>
  </reference>
  <reference>
    <citation>Shapiro MF, Greenfield S. The complete blood count and leukocyte differential count. An approach to their rational application. Ann Intern Med. 1987 Jan;106(1):65-74. doi: 10.7326/0003-4819-106-1-65.</citation>
    <PMID>3538968</PMID>
  </reference>
  <reference>
    <citation>Seebach JD, Morant R, Ruegg R, Seifert B, Fehr J. The diagnostic value of the neutrophil left shift in predicting inflammatory and infectious disease. Am J Clin Pathol. 1997 May;107(5):582-91. doi: 10.1093/ajcp/107.5.582.</citation>
    <PMID>9128272</PMID>
  </reference>
  <reference>
    <citation>Wyllie DH, Bowler IC, Peto TE. Bacteraemia prediction in emergency medical admissions: role of C reactive protein. J Clin Pathol. 2005 Apr;58(4):352-6. doi: 10.1136/jcp.2004.022293.</citation>
    <PMID>15790696</PMID>
  </reference>
  <reference>
    <citation>Chalupa P, Beran O, Herwald H, Kasprikova N, Holub M. Evaluation of potential biomarkers for the discrimination of bacterial and viral infections. Infection. 2011 Oct;39(5):411-7. doi: 10.1007/s15010-011-0126-4. Epub 2011 Jul 1.</citation>
    <PMID>21720792</PMID>
  </reference>
  <reference>
    <citation>de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care. 2010;14(5):R192. doi: 10.1186/cc9309. Epub 2010 Oct 29.</citation>
    <PMID>21034463</PMID>
  </reference>
  <reference>
    <citation>Terradas R, Grau S, Blanch J, Riu M, Saballs P, Castells X, Horcajada JP, Knobel H. Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study. PLoS One. 2012;7(8):e42860. doi: 10.1371/journal.pone.0042860. Epub 2012 Aug 9.</citation>
    <PMID>22912753</PMID>
  </reference>
  <reference>
    <citation>Mariappan P, Smith G, Moussa SA, Tolley DA. One week of ciprofloxacin before percutaneous nephrolithotomy significantly reduces upper tract infection and urosepsis: a prospective controlled study. BJU Int. 2006 Nov;98(5):1075-9. doi: 10.1111/j.1464-410X.2006.06450.x.</citation>
    <PMID>17034608</PMID>
  </reference>
  <reference>
    <citation>Dogan HS, Sahin A, Cetinkaya Y, Akdogan B, Ozden E, Kendi S. Antibiotic prophylaxis in percutaneous nephrolithotomy: prospective study in 81 patients. J Endourol. 2002 Nov;16(9):649-53. doi: 10.1089/089277902761402989.</citation>
    <PMID>12490017</PMID>
  </reference>
  <reference>
    <citation>Seyrek M, Binbay M, Yuruk E, Akman T, Aslan R, Yazici O, Berberoglu Y, Muslumanoglu AY. Perioperative prophylaxis for percutaneous nephrolithotomy: randomized study concerning the drug and dosage. J Endourol. 2012 Nov;26(11):1431-6. doi: 10.1089/end.2012.0242. Epub 2012 Aug 2.</citation>
    <PMID>22612061</PMID>
  </reference>
  <reference>
    <citation>Demirtas A, Yildirim YE, Sofikerim M, Kaya EG, Akinsal EC, Tombul ST, Ekmekcioglu O, Gulmez I. Comparison of infection and urosepsis rates of ciprofloxacin and ceftriaxone prophylaxis before percutaneous nephrolithotomy: a prospective and randomised study. ScientificWorldJournal. 2012;2012:916381. doi: 10.1100/2012/916381. Epub 2012 Dec 17.</citation>
    <PMID>23319889</PMID>
  </reference>
  <reference>
    <citation>Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14. English, Slovak.</citation>
    <PMID>11723675</PMID>
  </reference>
  <reference>
    <citation>Goodman DA, Goodman CB, Monk JS. Use of the neutrophil:lymphocyte ratio in the diagnosis of appendicitis. Am Surg. 1995 Mar;61(3):257-9.</citation>
    <PMID>7887542</PMID>
  </reference>
  <reference>
    <citation>de Jager CP, Wever PC, Gemen EF, Kusters R, van Gageldonk-Lafeber AB, van der Poll T, Laheij RJ. The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia. PLoS One. 2012;7(10):e46561. doi: 10.1371/journal.pone.0046561. Epub 2012 Oct 1.</citation>
    <PMID>23049706</PMID>
  </reference>
  <reference>
    <citation>Tang K, Liu H, Jiang K, Ye T, Yan L, Liu P, Xia D, Chen Z, Xu H, Ye Z. Predictive value of preoperative inflammatory response biomarkers for metabolic syndrome and post-PCNL systemic inflammatory response syndrome in patients with nephrolithiasis. Oncotarget. 2017 Aug 18;8(49):85612-85627. doi: 10.18632/oncotarget.20344. eCollection 2017 Oct 17.</citation>
    <PMID>29156745</PMID>
  </reference>
  <reference>
    <citation>Cetinkaya M, Buldu I, Kurt O, Inan R. Platelet-to-Lymphocyte Ratio: A New Factor for Predicting Systemic Inflammatory Response Syndrome after Percutaneous Nephrolithotomy. Urol J. 2017 Aug 29;14(5):4089-4093.</citation>
    <PMID>28853103</PMID>
  </reference>
  <reference>
    <citation>Sen V, Bozkurt IH, Aydogdu O, Yonguc T, Yarimoglu S, Sen P, Koras O, Degirmenci T. Significance of preoperative neutrophil-lymphocyte count ratio on predicting postoperative sepsis after percutaneous nephrolithotomy. Kaohsiung J Med Sci. 2016 Oct;32(10):507-513. doi: 10.1016/j.kjms.2016.08.008. Epub 2016 Sep 9.</citation>
    <PMID>27742034</PMID>
  </reference>
  <verification_date>December 2018</verification_date>
  <study_first_submitted>December 9, 2018</study_first_submitted>
  <study_first_submitted_qc>December 12, 2018</study_first_submitted_qc>
  <study_first_posted type="Actual">December 13, 2018</study_first_posted>
  <last_update_submitted>December 12, 2018</last_update_submitted>
  <last_update_submitted_qc>December 12, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">December 13, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>TC Erciyes University</investigator_affiliation>
    <investigator_full_name>Abdullah Demirtas</investigator_full_name>
    <investigator_title>Assoc.Prof.</investigator_title>
  </responsible_party>
  <keyword>fever</keyword>
  <keyword>bacteremia</keyword>
  <keyword>lymphocytes</keyword>
  <keyword>percutaneous nephrolithotomy</keyword>
  <keyword>neutrophil-lymphocyte ratio</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Urinary Tract Infections</mesh_term>
    <mesh_term>Bacterial Infections</mesh_term>
    <mesh_term>Nephrolithiasis</mesh_term>
    <mesh_term>Kidney Calculi</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03774940
org study id: 2013/198
nct id: NCT03774940
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
To investigate the relationship between neutrophil count, lymphocyte count,
      neutrophil-to-lymphocyte count ratio (NLR), and postoperative fever in patients undergoing
      percutaneous nephrolithotomy (PNL).
Percutaneous nephrolithotomy (PNL) is a minimally invasive treatment commonly used for renal
      calculi. However, the prevalence of postoperative fever is reported to be 16.7%-35%, even
      with appropriate prophylactic antibiotic therapy and a sterile urine culture. The most
      probable causes are urinary extravasation and bacteremia. Although it is important to
      postoperatively isolate the causative bacteria, bacterial isolation may not always be
      possible, and urinary and blood cultures may prove negative. In addition, establishing the
      etiology of fever could be time-consuming and the techniques involved may generate
      pseudo-negative results owing to several factors, especially the antibiotics used
      prophylactically. This can result in a prolonged hospital stay and increased the cost of
      patient care.

      The most commonly used parameters for the early diagnosis of bacterial infections, despite
      their limited use, are C-reactive protein, white blood cell count, and neutrophil count .
      Superior parameters include procalcitonin, pro-adrenomedullin, interleukin (IL)-6, and IL-8,
      but their use is limited by their lack of availability in some centers and their higher
      costs. Recently, the ratio of neutrophil count to lymphocyte count (NLR) has been proposed as
      an effective, simple, and useful biomarker for the early diagnosis of bacterial infections.
      However, these tests are used after the emergence of fever. As yet, no single parameter has
      been proposed for predicting postoperative fever in the absence of preoperative factors known
      to cause fever.

      The aim of this study was to investigate whether neutrophil count, lymphocyte count, and NLR
      obtained from routine preoperative blood tests could be used in predicting fever following
      PNL in patients with no risk factors for infection.
allocation: Non-Randomized
intervention model: Parallel Assignment
primary purpose: Prevention
masking: None (Open Label)
measure: White blood cell count
time frame: preoperative
description: white blood cell count
measure: Neutrophil count
time frame: preoperative
description: neutrophil count
measure: N/L
time frame: preoperative
description: ratio of neutrophil count to lymphocyte count
measure: Lymphocyte count
time frame: preoperative
description: Lymphocyte count
arm group label: fever
arm group type: Experimental
description: patients that have fever after PNL
arm group label: No fever
arm group type: Active Comparator
description: Patients without fever after PNL
intervention type: Diagnostic Test
intervention name: peripheric blood count
description: preoperative peripheric blood count
arm group label: No fever
arm group label: fever
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
last name: Abdullah Demirtas, MD
role: Principal Investigator
affiliation: Erciyes University Faculty of Medicine
facility: 
country: Turkey
citation: Draga RO, Kok ET, Sorel MR, Bosch RJ, Lock TM. Percutaneous nephrolithotomy: factors associated with fever after the first postoperative day and systemic inflammatory response syndrome. J Endourol. 2009 Jun;23(6):921-7. doi: 10.1089/end.2009.0041.
PMID: 19473071
citation: Cadeddu JA, Chen R, Bishoff J, Micali S, Kumar A, Moore RG, Kavoussi LR. Clinical significance of fever after percutaneous nephrolithotomy. Urology. 1998 Jul;52(1):48-50. doi: 10.1016/s0090-4295(98)00146-0.
PMID: 9671869
citation: Sharifi Aghdas F, Akhavizadegan H, Aryanpoor A, Inanloo H, Karbakhsh M. Fever after percutaneous nephrolithotomy: contributing factors. Surg Infect (Larchmt). 2006 Aug;7(4):367-71. doi: 10.1089/sur.2006.7.367.
PMID: 16978080
citation: Nuutila J, Lilius EM. Distinction between bacterial and viral infections. Curr Opin Infect Dis. 2007 Jun;20(3):304-10. doi: 10.1097/QCO.0b013e3280964db4.
PMID: 17471042
citation: Lutfiyya MN, Henley E, Chang LF, Reyburn SW. Diagnosis and treatment of community-acquired pneumonia. Am Fam Physician. 2006 Feb 1;73(3):442-50.
PMID: 16477891
citation: Shapiro MF, Greenfield S. The complete blood count and leukocyte differential count. An approach to their rational application. Ann Intern Med. 1987 Jan;106(1):65-74. doi: 10.7326/0003-4819-106-1-65.
PMID: 3538968
citation: Seebach JD, Morant R, Ruegg R, Seifert B, Fehr J. The diagnostic value of the neutrophil left shift in predicting inflammatory and infectious disease. Am J Clin Pathol. 1997 May;107(5):582-91. doi: 10.1093/ajcp/107.5.582.
PMID: 9128272
citation: Wyllie DH, Bowler IC, Peto TE. Bacteraemia prediction in emergency medical admissions: role of C reactive protein. J Clin Pathol. 2005 Apr;58(4):352-6. doi: 10.1136/jcp.2004.022293.
PMID: 15790696
citation: Chalupa P, Beran O, Herwald H, Kasprikova N, Holub M. Evaluation of potential biomarkers for the discrimination of bacterial and viral infections. Infection. 2011 Oct;39(5):411-7. doi: 10.1007/s15010-011-0126-4. Epub 2011 Jul 1.
PMID: 21720792
citation: de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care. 2010;14(5):R192. doi: 10.1186/cc9309. Epub 2010 Oct 29.
PMID: 21034463
citation: Terradas R, Grau S, Blanch J, Riu M, Saballs P, Castells X, Horcajada JP, Knobel H. Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study. PLoS One. 2012;7(8):e42860. doi: 10.1371/journal.pone.0042860. Epub 2012 Aug 9.
PMID: 22912753
citation: Mariappan P, Smith G, Moussa SA, Tolley DA. One week of ciprofloxacin before percutaneous nephrolithotomy significantly reduces upper tract infection and urosepsis: a prospective controlled study. BJU Int. 2006 Nov;98(5):1075-9. doi: 10.1111/j.1464-410X.2006.06450.x.
PMID: 17034608
citation: Dogan HS, Sahin A, Cetinkaya Y, Akdogan B, Ozden E, Kendi S. Antibiotic prophylaxis in percutaneous nephrolithotomy: prospective study in 81 patients. J Endourol. 2002 Nov;16(9):649-53. doi: 10.1089/089277902761402989.
PMID: 12490017
citation: Seyrek M, Binbay M, Yuruk E, Akman T, Aslan R, Yazici O, Berberoglu Y, Muslumanoglu AY. Perioperative prophylaxis for percutaneous nephrolithotomy: randomized study concerning the drug and dosage. J Endourol. 2012 Nov;26(11):1431-6. doi: 10.1089/end.2012.0242. Epub 2012 Aug 2.
PMID: 22612061
citation: Demirtas A, Yildirim YE, Sofikerim M, Kaya EG, Akinsal EC, Tombul ST, Ekmekcioglu O, Gulmez I. Comparison of infection and urosepsis rates of ciprofloxacin and ceftriaxone prophylaxis before percutaneous nephrolithotomy: a prospective and randomised study. ScientificWorldJournal. 2012;2012:916381. doi: 10.1100/2012/916381. Epub 2012 Dec 17.
PMID: 23319889
citation: Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14. English, Slovak.
PMID: 11723675
citation: Goodman DA, Goodman CB, Monk JS. Use of the neutrophil:lymphocyte ratio in the diagnosis of appendicitis. Am Surg. 1995 Mar;61(3):257-9.
PMID: 7887542
citation: de Jager CP, Wever PC, Gemen EF, Kusters R, van Gageldonk-Lafeber AB, van der Poll T, Laheij RJ. The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia. PLoS One. 2012;7(10):e46561. doi: 10.1371/journal.pone.0046561. Epub 2012 Oct 1.
PMID: 23049706
citation: Tang K, Liu H, Jiang K, Ye T, Yan L, Liu P, Xia D, Chen Z, Xu H, Ye Z. Predictive value of preoperative inflammatory response biomarkers for metabolic syndrome and post-PCNL systemic inflammatory response syndrome in patients with nephrolithiasis. Oncotarget. 2017 Aug 18;8(49):85612-85627. doi: 10.18632/oncotarget.20344. eCollection 2017 Oct 17.
PMID: 29156745
citation: Cetinkaya M, Buldu I, Kurt O, Inan R. Platelet-to-Lymphocyte Ratio: A New Factor for Predicting Systemic Inflammatory Response Syndrome after Percutaneous Nephrolithotomy. Urol J. 2017 Aug 29;14(5):4089-4093.
PMID: 28853103
citation: Sen V, Bozkurt IH, Aydogdu O, Yonguc T, Yarimoglu S, Sen P, Koras O, Degirmenci T. Significance of preoperative neutrophil-lymphocyte count ratio on predicting postoperative sepsis after percutaneous nephrolithotomy. Kaohsiung J Med Sci. 2016 Oct;32(10):507-513. doi: 10.1016/j.kjms.2016.08.008. Epub 2016 Sep 9.
PMID: 27742034
responsible party type: Principal Investigator
investigator affiliation: TC Erciyes University
investigator full name: Abdullah Demirtas
investigator title: Assoc.Prof.
mesh term: Urinary Tract Infections
mesh term: Bacterial Infections
mesh term: Nephrolithiasis
mesh term: Kidney Calculi
sharing ipd: No