<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03782155</url>
  </required_header>
  <id_info>
    <org_study_id>DI/17/111/03/014</org_study_id>
    <nct_id>NCT03782155</nct_id>
  </id_info>
  <brief_title>Effect of Supplementation With HMB and Glutamine in Wound Healing on Bloody Areas</brief_title>
  <official_title>Effect of Supplementation With b- Hydroxy Methyl Butyrate and Glutamine in Wound Healing Histology in Type 2 Diabetes and Controls Bloody Areas</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Hospital General de Mexico</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Hospital General de Mexico</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
    <is_us_export>No</is_us_export>
  </oversight_info>
  <brief_summary>
    <textblock>
      A randomized controlled clinical trial in two groups of supplementation with HMB and&#xD;
      glutamine. Each group consist in 25 patients with bloody areas, one group will receive and&#xD;
      intervention with HMB and Glutamine and the other will receive a placebo with calcium&#xD;
      caseinate.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      A fundamental part of the integral management of wound healing in patients with bloody areas&#xD;
      is nutrition, since it involves biochemical events that depend on the substrates it provides.&#xD;
      Wound healing is a phase that demands higher needs of energy-protein than the requirement.&#xD;
      Problem statement: Poor nutrition decreases, through specific phases, normal processes that&#xD;
      allow the progression of wound healing. Nutrient deficiencies can have negative effects on&#xD;
      wound healing by prolonging the inflammatory phase, decreasing fibroblast proliferation, and&#xD;
      modifying collagen synthesis. Some amino acids are essential for the process, such as&#xD;
      Glutamine and Hydroxymethylbutyrate.&#xD;
&#xD;
      Objective: To evaluate the effect of Glutamine and Hydroxymethylbutyrate supplementation over&#xD;
      the cells involved in wound healing of bloody areas. Hypothesis: Glutamine and&#xD;
      Hydroxymethylbutyrate supplementation promotes a positive effect over the cells involved in&#xD;
      wound healing of bloody areas. Methodology: A randomized controlled clinical trial, in&#xD;
      patients with diagnosis of bloody areas. They will be divided into two groups, the first will&#xD;
      receive an intervention with Glutamine (14g) and Hydroxymethylbutyrate (3g) and a control&#xD;
      group will receive a placebo with calcium caseinate (17g)&#xD;
&#xD;
      A sample of the affected tissue will be taken before and after the supplementation where&#xD;
      histology will be analyzed.&#xD;
&#xD;
      Remains of tissue will be obteined during surgery wash for histology.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Not yet recruiting</last_known_status>
  <start_date type="Anticipated">June 1, 2021</start_date>
  <completion_date type="Anticipated">December 31, 2021</completion_date>
  <primary_completion_date type="Anticipated">August 1, 2021</primary_completion_date>
  <phase>Phase 4</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>A randomized clinical trial study</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Triple (Participant, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Wound healing:Number of cells per clauster in tissue sample of wound.</measure>
    <time_frame>15 days</time_frame>
    <description>To evaluate the effect of supplementation in cellular differentiation. It will be counted and compared the number of cells per cluster in a tissue sample (lymphocytes, fibroblasts , macrophages and angiogeny) at the begining and after the supplementation.</description>
  </primary_outcome>
  <other_outcome>
    <measure>Bates- Jensen wound tool</measure>
    <time_frame>15 days</time_frame>
    <description>To compared Bates- Jensen questionnaire will be applied two evaluations: first will be done before supplementation and second after finished the supplementation this scale consider physical characteristics of wound and give a punctuation 1 to 5 in each item ( size, depht, borders, necrosis, percentage of necrotic tissue , type of exudate, amount of exudate, skin color, edema, induration, granular tissue,epithelialization) according to this, items have a value that will be considered in a total punctuation of wound Punctuation 1-12 Health tissue 13- 59 regeneration 60. Degeneration</description>
  </other_outcome>
  <other_outcome>
    <measure>Biochemical serum values of CPR</measure>
    <time_frame>15 days</time_frame>
    <description>To evaluate and compared the values of serum CPR, two different serum samples ( at the beginning and after finished the supplementation)</description>
  </other_outcome>
  <other_outcome>
    <measure>Biochemical serum values of creatinine</measure>
    <time_frame>15 days</time_frame>
    <description>To evaluate and compared the values of serum creatinine, two different serum samples ( at the beginning and after finished the supplementation)</description>
  </other_outcome>
  <other_outcome>
    <measure>Biochemical serum values of procalcitonine</measure>
    <time_frame>15 days</time_frame>
    <description>To evaluate and compared the values of serum procalcitonine, two different serum samples ( at the beginning and after finished the supplementation)</description>
  </other_outcome>
  <other_outcome>
    <measure>Bacterial growth per clauster in culture wound</measure>
    <time_frame>15 days</time_frame>
    <description>It will be taken a bacterial culture of wound in two different moments ( at the beginning and after finished the supplementation) Will be counted the colony number per clauster and type of bacteria.</description>
  </other_outcome>
  <other_outcome>
    <measure>Type of bacterial growth in wound</measure>
    <time_frame>15 days</time_frame>
    <description>It will be taken a bacterial culture of wound in two different moments ( at the beginning and after finished the supplementation) will be counted the kind of bacteria.</description>
  </other_outcome>
  <other_outcome>
    <measure>Glucemic control by glucose</measure>
    <time_frame>15 days</time_frame>
    <description>Glucose control will be messured in serum sample (mg/dL) in two different moments: at the begining and after finished the supplementation.</description>
  </other_outcome>
  <other_outcome>
    <measure>Glucemic control by HbA1c</measure>
    <time_frame>15 days</time_frame>
    <description>HbA1c(%) control will be messured in serum in two different moments: at the begining and after finished the supplementation.</description>
  </other_outcome>
  <other_outcome>
    <measure>Incidence of treatment- adverse events</measure>
    <time_frame>15 days</time_frame>
    <description>Each day of supplementation will be performed a questionary about subjective syntoms( as abdominal pain, diarrhea, nausea, vomiting, constipation or others) of supplementation,</description>
  </other_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">30</enrollment>
  <condition>Wound Healing</condition>
  <condition>Diabetic</condition>
  <arm_group>
    <arm_group_label>HMB and glutamine supplementation</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Patients with type 2 diabetes with supplementation HMB 3g, powder once a day and glutamine powder 14g once a day supplementation during 15 days.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>placebo patients</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Patients with type 2 diabetes with placebo( calcium caseinate) supplementation during 15 days 17g of powder once a day</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>glutamine supplementation</intervention_name>
    <description>powder 14g</description>
    <arm_group_label>HMB and glutamine supplementation</arm_group_label>
    <other_name>Glutamine</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>HMB</intervention_name>
    <description>powder 3g</description>
    <arm_group_label>HMB and glutamine supplementation</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Placebo</intervention_name>
    <description>powder 17g</description>
    <arm_group_label>placebo patients</arm_group_label>
    <other_name>Calcic caseinate</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patients with bloody areas at hospital admission&#xD;
&#xD;
          -  Hospital length stay around 15 days&#xD;
&#xD;
          -  Medical treatment with surgical washing and negative pressure systems&#xD;
&#xD;
          -  For the groups with diabetes, patients with diagnosis of type 2 diabetes with bloody&#xD;
             areas.&#xD;
&#xD;
          -  Patients that accepts and signs the informative consent.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  patients with cancer or immunodeficiency&#xD;
&#xD;
          -  patients with HbA1c &lt; 12&#xD;
&#xD;
          -  patients with collagen disease&#xD;
&#xD;
          -  patients with allergy to intervention substances (HMB, glutamine)&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>65 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Vanessa Fuchs, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Hospital General de México</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Vanessa Fuchs, PhD</last_name>
    <phone>551 85331635</phone>
    <email>vanessafuchs@gmail.com</email>
  </overall_contact>
  <location>
    <facility>
      <name>Hospital General de México</name>
      <address>
        <city>Mexico City</city>
        <country>Mexico</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Mexico</country>
  </location_countries>
  <reference>
    <citation>Wild T, Rahbarnia A, Kellner M, Sobotka L, Eberlein T. Basics in nutrition and wound healing. Nutrition. 2010 Sep;26(9):862-6. doi: 10.1016/j.nut.2010.05.008.</citation>
    <PMID>20692599</PMID>
  </reference>
  <reference>
    <citation>Molnar JA, Vlad LG, Gumus T. Nutrition and Chronic Wounds: Improving Clinical Outcomes. Plast Reconstr Surg. 2016 Sep;138(3 Suppl):71S-81S. doi: 10.1097/PRS.0000000000002676.</citation>
    <PMID>27556777</PMID>
  </reference>
  <reference>
    <citation>Stechmiller JK. Understanding the role of nutrition and wound healing. Nutr Clin Pract. 2010 Feb;25(1):61-8. doi: 10.1177/0884533609358997.</citation>
    <PMID>20130158</PMID>
  </reference>
  <reference>
    <citation>Gundogdu RH, Temel H, Bozkirli BO, Ersoy E, Yazgan A, Yildirim Z. Mixture of Arginine, Glutamine, and beta-hydroxy-beta-methyl Butyrate Enhances the Healing of Ischemic Wounds in Rats. JPEN J Parenter Enteral Nutr. 2017 Aug;41(6):1045-1050. doi: 10.1177/0148607115625221. Epub 2016 Jan 29.</citation>
    <PMID>26826258</PMID>
  </reference>
  <reference>
    <citation>Bozkirli BO, Gundogdu RH, Ersoy E, Lortlar N, Yildirim Z, Temel H, Oduncu M, Karakaya J. Pilot Experimental Study on the Effect of Arginine, Glutamine, and beta-Hydroxy beta-Methylbutyrate on Secondary Wound Healing. JPEN J Parenter Enteral Nutr. 2015 Jul;39(5):591-7. doi: 10.1177/0148607113520433. Epub 2014 Jan 24.</citation>
    <PMID>24463351</PMID>
  </reference>
  <reference>
    <citation>Armstrong DG, Hanft JR, Driver VR, Smith AP, Lazaro-Martinez JL, Reyzelman AM, Furst GJ, Vayser DJ, Cervantes HL, Snyder RJ, Moore MF, May PE, Nelson JL, Baggs GE, Voss AC; Diabetic Foot Nutrition Study Group. Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial. Diabet Med. 2014 Sep;31(9):1069-77. doi: 10.1111/dme.12509. Epub 2014 Jun 19.</citation>
    <PMID>24867069</PMID>
  </reference>
  <reference>
    <citation>Wong A, Chew A, Wang CM, Ong L, Zhang SH, Young S. The use of a specialised amino acid mixture for pressure ulcers: a placebo-controlled trial. J Wound Care. 2014 May;23(5):259-60, 262-4, 266-9. doi: 10.12968/jowc.2014.23.5.259.</citation>
    <PMID>24810310</PMID>
  </reference>
  <reference>
    <citation>Harris C, Bates-Jensen B, Parslow N, Raizman R, Singh M, Ketchen R. Bates-Jensen wound assessment tool: pictorial guide validation project. J Wound Ostomy Continence Nurs. 2010 May-Jun;37(3):253-9. doi: 10.1097/WON.0b013e3181d73aab.</citation>
    <PMID>20386331</PMID>
  </reference>
  <results_reference>
    <citation>Salas-Gonzalez P, Sevilla- Gonzalez M de la L, Fuchs- Tarlovsky V. Effect of supplementation with glutamine and hydroxymethylbutirate over the cellsinvolved un wound healing. Int J Adv Res. 2018 Aug 31;6(8):100-6.</citation>
  </results_reference>
  <results_reference>
    <citation>Sipahi S, Gungor O, Gunduz M, Cilci M, Demirci MC, Tamer A. The effect of oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine and glutamine on wound healing: a retrospective analysis of diabetic haemodialysis patients. BMC Nephrol. 2013 Jan 12;14:8. doi: 10.1186/1471-2369-14-8.</citation>
    <PMID>23311725</PMID>
  </results_reference>
  <results_reference>
    <citation>Rathmacher JA, Nissen S, Panton L, Clark RH, Eubanks May P, Barber AE, D'Olimpio J, Abumrad NN. Supplementation with a combination of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters. JPEN J Parenter Enteral Nutr. 2004 Mar-Apr;28(2):65-75. doi: 10.1177/014860710402800265.</citation>
    <PMID>15080599</PMID>
  </results_reference>
  <verification_date>September 2020</verification_date>
  <study_first_submitted>October 15, 2018</study_first_submitted>
  <study_first_submitted_qc>December 18, 2018</study_first_submitted_qc>
  <study_first_posted type="Actual">December 20, 2018</study_first_posted>
  <last_update_submitted>September 2, 2020</last_update_submitted>
  <last_update_submitted_qc>September 2, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">September 3, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Hospital General de Mexico</investigator_affiliation>
    <investigator_full_name>Dr. Vanessa Fuchs Tarlovsky</investigator_full_name>
    <investigator_title>Head of clinical nutrition</investigator_title>
  </responsible_party>
  <keyword>wound healing, diabetes wound healing</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Wounds and Injuries</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03782155
org study id: DI/17/111/03/014
nct id: NCT03782155
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
is us export: No
A randomized controlled clinical trial in two groups of supplementation with HMB and
      glutamine. Each group consist in 25 patients with bloody areas, one group will receive and
      intervention with HMB and Glutamine and the other will receive a placebo with calcium
      caseinate.
A fundamental part of the integral management of wound healing in patients with bloody areas
      is nutrition, since it involves biochemical events that depend on the substrates it provides.
      Wound healing is a phase that demands higher needs of energy-protein than the requirement.
      Problem statement: Poor nutrition decreases, through specific phases, normal processes that
      allow the progression of wound healing. Nutrient deficiencies can have negative effects on
      wound healing by prolonging the inflammatory phase, decreasing fibroblast proliferation, and
      modifying collagen synthesis. Some amino acids are essential for the process, such as
      Glutamine and Hydroxymethylbutyrate.

      Objective: To evaluate the effect of Glutamine and Hydroxymethylbutyrate supplementation over
      the cells involved in wound healing of bloody areas. Hypothesis: Glutamine and
      Hydroxymethylbutyrate supplementation promotes a positive effect over the cells involved in
      wound healing of bloody areas. Methodology: A randomized controlled clinical trial, in
      patients with diagnosis of bloody areas. They will be divided into two groups, the first will
      receive an intervention with Glutamine (14g) and Hydroxymethylbutyrate (3g) and a control
      group will receive a placebo with calcium caseinate (17g)

      A sample of the affected tissue will be taken before and after the supplementation where
      histology will be analyzed.

      Remains of tissue will be obteined during surgery wash for histology.
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: A randomized clinical trial study
primary purpose: Treatment
masking: Triple (Participant, Investigator, Outcomes Assessor)
measure: Wound healing:Number of cells per clauster in tissue sample of wound.
time frame: 15 days
description: To evaluate the effect of supplementation in cellular differentiation. It will be counted and compared the number of cells per cluster in a tissue sample (lymphocytes, fibroblasts , macrophages and angiogeny) at the begining and after the supplementation.
measure: Bates- Jensen wound tool
time frame: 15 days
description: To compared Bates- Jensen questionnaire will be applied two evaluations: first will be done before supplementation and second after finished the supplementation this scale consider physical characteristics of wound and give a punctuation 1 to 5 in each item ( size, depht, borders, necrosis, percentage of necrotic tissue , type of exudate, amount of exudate, skin color, edema, induration, granular tissue,epithelialization) according to this, items have a value that will be considered in a total punctuation of wound Punctuation 1-12 Health tissue 13- 59 regeneration 60. Degeneration
measure: Biochemical serum values of CPR
time frame: 15 days
description: To evaluate and compared the values of serum CPR, two different serum samples ( at the beginning and after finished the supplementation)
measure: Biochemical serum values of creatinine
time frame: 15 days
description: To evaluate and compared the values of serum creatinine, two different serum samples ( at the beginning and after finished the supplementation)
measure: Biochemical serum values of procalcitonine
time frame: 15 days
description: To evaluate and compared the values of serum procalcitonine, two different serum samples ( at the beginning and after finished the supplementation)
measure: Bacterial growth per clauster in culture wound
time frame: 15 days
description: It will be taken a bacterial culture of wound in two different moments ( at the beginning and after finished the supplementation) Will be counted the colony number per clauster and type of bacteria.
measure: Type of bacterial growth in wound
time frame: 15 days
description: It will be taken a bacterial culture of wound in two different moments ( at the beginning and after finished the supplementation) will be counted the kind of bacteria.
measure: Glucemic control by glucose
time frame: 15 days
description: Glucose control will be messured in serum sample (mg/dL) in two different moments: at the begining and after finished the supplementation.
measure: Glucemic control by HbA1c
time frame: 15 days
description: HbA1c(%) control will be messured in serum in two different moments: at the begining and after finished the supplementation.
measure: Incidence of treatment- adverse events
time frame: 15 days
description: Each day of supplementation will be performed a questionary about subjective syntoms( as abdominal pain, diarrhea, nausea, vomiting, constipation or others) of supplementation,
arm group label: HMB and glutamine supplementation
arm group type: Experimental
description: Patients with type 2 diabetes with supplementation HMB 3g, powder once a day and glutamine powder 14g once a day supplementation during 15 days.
arm group label: placebo patients
arm group type: Placebo Comparator
description: Patients with type 2 diabetes with placebo( calcium caseinate) supplementation during 15 days 17g of powder once a day
intervention type: Drug
intervention name: glutamine supplementation
description: powder 14g
arm group label: HMB and glutamine supplementation
other name: Glutamine
intervention type: Drug
intervention name: HMB
description: powder 3g
arm group label: HMB and glutamine supplementation
intervention type: Drug
intervention name: Placebo
description: powder 17g
arm group label: placebo patients
other name: Calcic caseinate
criteria: 
gender: All
minimum age: 18 Years
maximum age: 65 Years
healthy volunteers: No
last name: Vanessa Fuchs, PhD
role: Principal Investigator
affiliation: Hospital General de México
last name: Vanessa Fuchs, PhD
phone: 551 85331635
email: vanessafuchs@gmail.com
facility: 
country: Mexico
citation: Wild T, Rahbarnia A, Kellner M, Sobotka L, Eberlein T. Basics in nutrition and wound healing. Nutrition. 2010 Sep;26(9):862-6. doi: 10.1016/j.nut.2010.05.008.
PMID: 20692599
citation: Molnar JA, Vlad LG, Gumus T. Nutrition and Chronic Wounds: Improving Clinical Outcomes. Plast Reconstr Surg. 2016 Sep;138(3 Suppl):71S-81S. doi: 10.1097/PRS.0000000000002676.
PMID: 27556777
citation: Stechmiller JK. Understanding the role of nutrition and wound healing. Nutr Clin Pract. 2010 Feb;25(1):61-8. doi: 10.1177/0884533609358997.
PMID: 20130158
citation: Gundogdu RH, Temel H, Bozkirli BO, Ersoy E, Yazgan A, Yildirim Z. Mixture of Arginine, Glutamine, and beta-hydroxy-beta-methyl Butyrate Enhances the Healing of Ischemic Wounds in Rats. JPEN J Parenter Enteral Nutr. 2017 Aug;41(6):1045-1050. doi: 10.1177/0148607115625221. Epub 2016 Jan 29.
PMID: 26826258
citation: Bozkirli BO, Gundogdu RH, Ersoy E, Lortlar N, Yildirim Z, Temel H, Oduncu M, Karakaya J. Pilot Experimental Study on the Effect of Arginine, Glutamine, and beta-Hydroxy beta-Methylbutyrate on Secondary Wound Healing. JPEN J Parenter Enteral Nutr. 2015 Jul;39(5):591-7. doi: 10.1177/0148607113520433. Epub 2014 Jan 24.
PMID: 24463351
citation: Armstrong DG, Hanft JR, Driver VR, Smith AP, Lazaro-Martinez JL, Reyzelman AM, Furst GJ, Vayser DJ, Cervantes HL, Snyder RJ, Moore MF, May PE, Nelson JL, Baggs GE, Voss AC; Diabetic Foot Nutrition Study Group. Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial. Diabet Med. 2014 Sep;31(9):1069-77. doi: 10.1111/dme.12509. Epub 2014 Jun 19.
PMID: 24867069
citation: Wong A, Chew A, Wang CM, Ong L, Zhang SH, Young S. The use of a specialised amino acid mixture for pressure ulcers: a placebo-controlled trial. J Wound Care. 2014 May;23(5):259-60, 262-4, 266-9. doi: 10.12968/jowc.2014.23.5.259.
PMID: 24810310
citation: Harris C, Bates-Jensen B, Parslow N, Raizman R, Singh M, Ketchen R. Bates-Jensen wound assessment tool: pictorial guide validation project. J Wound Ostomy Continence Nurs. 2010 May-Jun;37(3):253-9. doi: 10.1097/WON.0b013e3181d73aab.
PMID: 20386331
citation: Salas-Gonzalez P, Sevilla- Gonzalez M de la L, Fuchs- Tarlovsky V. Effect of supplementation with glutamine and hydroxymethylbutirate over the cellsinvolved un wound healing. Int J Adv Res. 2018 Aug 31;6(8):100-6.
citation: Sipahi S, Gungor O, Gunduz M, Cilci M, Demirci MC, Tamer A. The effect of oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine and glutamine on wound healing: a retrospective analysis of diabetic haemodialysis patients. BMC Nephrol. 2013 Jan 12;14:8. doi: 10.1186/1471-2369-14-8.
PMID: 23311725
citation: Rathmacher JA, Nissen S, Panton L, Clark RH, Eubanks May P, Barber AE, D'Olimpio J, Abumrad NN. Supplementation with a combination of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters. JPEN J Parenter Enteral Nutr. 2004 Mar-Apr;28(2):65-75. doi: 10.1177/014860710402800265.
PMID: 15080599
responsible party type: Principal Investigator
investigator affiliation: Hospital General de Mexico
investigator full name: Dr. Vanessa Fuchs Tarlovsky
investigator title: Head of clinical nutrition
mesh term: Wounds and Injuries
sharing ipd: Undecided