<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03840681</url>
  </required_header>
  <id_info>
    <org_study_id>MMetwally</org_study_id>
    <nct_id>NCT03840681</nct_id>
  </id_info>
  <brief_title>Assessment of Guided Bone Regeneration in Atrophic Anterior Maxilla</brief_title>
  <official_title>Assessment of Guided Bone Regeneration in Atrophic Anterior Maxilla Using Native Collagen vs Titanium Reinforced Polytetraflouroethelene Membranes Using an Organic Bovine Bone Mineral</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Cairo University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Cairo University</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Guided bone regeneration (GBR) is a surgical technique that uses barrier membranes to promote&#xD;
      osteoblast cells proliferation and exclude other cells such as epithelium and connective&#xD;
      tissue cells. GBR is often combined with bone grafting procedures.&#xD;
&#xD;
      Using Absorbable membranes like collagen membrane will reduce treatment time by decreasing&#xD;
      need for second surgery&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Assessment of Guided Bone Regeneration in Atrophic Anterior Maxilla using native Collagen vs&#xD;
      Titanium Reinforced Polytetraflouroethelene Membranes using an organic bovine Bone&#xD;
      mineral.Reconstructive surgery is necessary before implant placement to regenerate bone&#xD;
      defects caused by atrophy, dental trauma, extractions or periodontal disease . Success rate&#xD;
      of implants is related to the correct position and angulation of implants in residual crest,&#xD;
      so that height and thickness of bone augmentation can allow predictable results ,With this in&#xD;
      mind, it is important to establish sound clinical concepts with clearly defined parameters&#xD;
      that lead to successful esthetics in the anterior maxilla, with long-term stability of the&#xD;
      peri-implant tissues.&#xD;
&#xD;
      The most popular surgical procedures to obtain bone augmentation are: bone grafts, guided&#xD;
      bone regeneration, maxillary sinus floor elevation, and bone osteogenesis distraction.&#xD;
&#xD;
      Guided bone regeneration (GBR) is a surgical technique that uses barrier membranes to promote&#xD;
      osteoblast cells proliferation and exclude other cells such as epithelium and connective&#xD;
      tissue cells. GBR is often combined with bone grafting procedures.&#xD;
&#xD;
      Bone grafts are integrated into native bone with three different processes: osteogenesis,&#xD;
      osteoinduction and osteoconduction; Osteogenesis is the formation of new bone from&#xD;
      osteocompetent cells and is the only process where the graft itself can induce Bone&#xD;
      augmentation, Osteoinduction induces Bone Augmentation from the differentiation and&#xD;
      stimulation of mesenchymal cells by the bone-inductive proteins, Osteoconduction is the&#xD;
      formation of Bone Augmentation along a scaffold from osteocompetent cells of the recipient&#xD;
      site .&#xD;
&#xD;
      There are 2 Types of membranes:&#xD;
&#xD;
      III. Non Resorbable membrane IV. Resorbable membrane&#xD;
&#xD;
      Non-resorbable membranes:&#xD;
&#xD;
      With the presentation of the ﬁrst successful GBR procedures and the subsequent wide and&#xD;
      successful application of ePTFE membranes, this material became a standard for bone&#xD;
      regeneration. Expanded PTFE is characterized as a polymer with high stability in biological&#xD;
      systems. It resists breakdown by host tissues and by microbes and does not elicit immunologic&#xD;
      reactions. A frequent complication with membrane application in conjunction with implants is&#xD;
      membrane exposure and infection Wound dehiscence and membrane exposure have been reported to&#xD;
      impair the amount of bone regenerated in a number of experimental animal and clinical&#xD;
      investigations&#xD;
&#xD;
      Bioresorbable membranes:&#xD;
&#xD;
      The requirement of second surgical procedure for the removal of Non Resorbable barrier&#xD;
      membrane(NRBM) led to the introduction of bioresorbable barrier membranes (RBM). The&#xD;
      advantages of RBM compared to NRBM were as follows:&#xD;
&#xD;
        1. Improved soft tissue healing,&#xD;
&#xD;
        2. Incorporation of the membranes by the host tissues (depending on material properties),&#xD;
&#xD;
        3. Quick resorption in case of exposure, eliminating bacterial contamination. Today, a lot&#xD;
           of RBM are commercially available including collagen, freeze-dried fascia lata,&#xD;
           freeze-dried dura mater allografts, polyglactin-acid, polylactic acid, polyglycolic&#xD;
           acid, polyorthoester, polyurethane, polyhydroxybutyrate, etc.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Not yet recruiting</last_known_status>
  <start_date type="Anticipated">March 2019</start_date>
  <completion_date type="Anticipated">September 2019</completion_date>
  <primary_completion_date type="Anticipated">September 2019</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Outcomes Assessor)</masking>
    <masking_description>Each patient will be given a code by the researcher ( T.A ) and the observer will be blind to which group this case belongs Patients,evaluators and statistican will be blinded</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Height and width of bone gained</measure>
    <time_frame>After 6 monthes</time_frame>
    <description>Height and width of bone gained will be measured from CBCT</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Bone area percentage</measure>
    <time_frame>After 6 monthes</time_frame>
    <description>Bone area percentage will be measured by Histo-morphometric analysis</description>
  </primary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">20</enrollment>
  <condition>Guided Bone Regeneration</condition>
  <arm_group>
    <arm_group_label>Ridge augmentation by collagen membrane</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Intra operative procedures (for both groups) followed by CBCT will be taken for every patient.&#xD;
Local anesthesia will be given to the patient.&#xD;
Scrubbing and draping of the patient will be carried out in a standard fashion for intra oral procedures.&#xD;
Flap will be done.&#xD;
bone decortication will be done using surgical round bur, anorganic bovine bone derived mineral will be packed at defected area then covered at the defected area by a collagen membrane which will be stabilized by tacks.&#xD;
The site will then be copiously irrigated with saline in preparation for closure.&#xD;
The flap will then be closed using interrupted 4/0 resorbable sutures.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>augmentation by titanium reinforced PTFE</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Intra operative procedures (for both groups) followed by CBCT will be taken for every patient.&#xD;
Local anesthesia will be given to the patient.&#xD;
Scrubbing and draping of the patient will be carried out in a standard fashion for intra oral procedures.&#xD;
Flap will be done.&#xD;
bone decortication will be done using surgical round bur, anorganic bovine bone derived mineral will be packed at the defected area then covered by a titanium reinforced polytetraflouroethelene membrane which will be stabilized by tacks.&#xD;
The site will then be copiously irrigated with saline in preparation for closure.&#xD;
The flap will then be closed using interrupted 4/0 resorbable sutures.</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Augmentation</intervention_name>
    <description>non invasive technique to increase bone width and eliminate need for second surgery</description>
    <arm_group_label>Ridge augmentation by collagen membrane</arm_group_label>
    <arm_group_label>augmentation by titanium reinforced PTFE</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  • Patients with atrophied anterior maxillary ridge area.&#xD;
&#xD;
               -  Age: 18 years and older.&#xD;
&#xD;
               -  No intraoral soft and hard tissue pathology.&#xD;
&#xD;
               -  No systemic condition that contraindicate bone augmentation&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Heavy smokers more than 20 cigarettes per day.(32)&#xD;
&#xD;
          -  Patients with systemic disease that may affect normal healing.&#xD;
&#xD;
          -  Psychiatric problems.&#xD;
&#xD;
          -  Disorders to bone augmentation are related to history of radiation therapy to the head&#xD;
             and neck neoplasia.&#xD;
&#xD;
          -  Pregnant or nursing women.&#xD;
&#xD;
          -  Patients with uncontrolled diabetes mellitus, rheumatoid arthritis or osteoporosis.&#xD;
&#xD;
          -  Patient with previous history of radiotherapy.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Mohamed m Atef</last_name>
    <role>Principal Investigator</role>
    <affiliation>Cairo U</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Mohab f Metwally</last_name>
    <phone>00201115709990</phone>
    <email>hobaz90_2000@hotmail.com</email>
  </overall_contact>
  <reference>
    <citation>Lopez MA, Andreasi Bassi M, Confalone L, Carinci F. REGENERATION OF ATROPHIC CRESTAL RIDGES WITH RESORBABLE LAMINA: TECHNICAL NOTE. J Biol Regul Homeost Agents. 2015 Jul-Sep;29(3 Suppl 1):97-100.</citation>
    <PMID>26511187</PMID>
  </reference>
  <reference>
    <citation>Esposito M, Grusovin MG, Coulthard P, Worthington HV. The efficacy of various bone augmentation procedures for dental implants: a Cochrane systematic review of randomized controlled clinical trials. Int J Oral Maxillofac Implants. 2006 Sep-Oct;21(5):696-710.</citation>
    <PMID>17066630</PMID>
  </reference>
  <reference>
    <citation>Sorni M, Guarinos J, Garcia O, Penarrocha M. Implant rehabilitation of the atrophic upper jaw: a review of the literature since 1999. Med Oral Patol Oral Cir Bucal. 2005 Apr 1;10 Suppl 1:E45-56. English, Spanish.</citation>
    <PMID>15800467</PMID>
  </reference>
  <reference>
    <citation>Hoexter DL. Bone regeneration graft materials. J Oral Implantol. 2002;28(6):290-4. doi: 10.1563/1548-1336(2002)0282.3.CO;2.</citation>
    <PMID>12498538</PMID>
  </reference>
  <reference>
    <citation>Chiapasco M, Zaniboni M, Boisco M. Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants. Clin Oral Implants Res. 2006 Oct;17 Suppl 2:136-59. doi: 10.1111/j.1600-0501.2006.01357.x.</citation>
    <PMID>16968389</PMID>
  </reference>
  <reference>
    <citation>Karring T, Cortellini P, Lindhe J. Regenerative periodontal therapy. In: Lindhe J, Karring T, Lang NP, editors. Clinical periodontology and implant dentistry. Copenhagen: Munksgaard, 1997: 597-646.</citation>
  </reference>
  <reference>
    <citation>Schliephake H, Kracht D. Vertical ridge augmentation using polylactic membranes in conjunction with immediate implants in periodontally compromised extraction sites: an experimental study in dogs. Int J Oral Maxillofac Implants. 1997 May-Jun;12(3):325-34.</citation>
    <PMID>9197097</PMID>
  </reference>
  <reference>
    <citation>Gotfredsen K, Nimb L, Buser D, Hjorting-Hansen E. Evaluation of guided bone generation around implants placed into fresh extraction sockets: an experimental study in dogs. J Oral Maxillofac Surg. 1993 Aug;51(8):879-84; discussion 885-6. doi: 10.1016/s0278-2391(10)80108-9.</citation>
    <PMID>8336225</PMID>
  </reference>
  <reference>
    <citation>Kohal RJ, Trejo PM, Wirsching C, Hurzeler MB, Caffesse RG. Comparison of bioabsorbable and bioinert membranes for guided bone regeneration around non-submerged implants. An experimental study in the mongrel dog. Clin Oral Implants Res. 1999 Jun;10(3):226-37. doi: 10.1034/j.1600-0501.1999.100306.x.</citation>
    <PMID>10522183</PMID>
  </reference>
  <reference>
    <citation>Becker W, Dahlin C, Becker BE, Lekholm U, van Steenberghe D, Higuchi K, Kultje C. The use of e-PTFE barrier membranes for bone promotion around titanium implants placed into extraction sockets: a prospective multicenter study. Int J Oral Maxillofac Implants. 1994 Jan-Feb;9(1):31-40.</citation>
    <PMID>8150510</PMID>
  </reference>
  <reference>
    <citation>Gher ME, Quintero G, Assad D, Monaco E, Richardson AC. Bone grafting and guided bone regeneration for immediate dental implants in humans. J Periodontol. 1994 Sep;65(9):881-91. doi: 10.1902/jop.1994.65.9.881.</citation>
    <PMID>7990026</PMID>
  </reference>
  <reference>
    <citation>Elgali I, Omar O, Dahlin C, Thomsen P. Guided bone regeneration: materials and biological mechanisms revisited. Eur J Oral Sci. 2017 Oct;125(5):315-337. doi: 10.1111/eos.12364. Epub 2017 Aug 19.</citation>
    <PMID>28833567</PMID>
  </reference>
  <reference>
    <citation>McAllister BS, Haghighat K. Bone augmentation techniques. J Periodontol. 2007 Mar;78(3):377-96. doi: 10.1902/jop.2007.060048.</citation>
    <PMID>17335361</PMID>
  </reference>
  <reference>
    <citation>Hutmacher D, Hurzeler MB, Schliephake H. A review of material properties of biodegradable and bioresorbable polymers and devices for GTR and GBR applications. Int J Oral Maxillofac Implants. 1996 Sep-Oct;11(5):667-78.</citation>
    <PMID>8908867</PMID>
  </reference>
  <verification_date>February 2019</verification_date>
  <study_first_submitted>February 11, 2019</study_first_submitted>
  <study_first_submitted_qc>February 12, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">February 15, 2019</study_first_posted>
  <last_update_submitted>February 12, 2019</last_update_submitted>
  <last_update_submitted_qc>February 12, 2019</last_update_submitted_qc>
  <last_update_posted type="Actual">February 15, 2019</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Cairo University</investigator_affiliation>
    <investigator_full_name>Mohab Fathy Metwally</investigator_full_name>
    <investigator_title>Master student</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Atrophy</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03840681
org study id: MMetwally
nct id: NCT03840681
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
Guided bone regeneration (GBR) is a surgical technique that uses barrier membranes to promote
      osteoblast cells proliferation and exclude other cells such as epithelium and connective
      tissue cells. GBR is often combined with bone grafting procedures.

      Using Absorbable membranes like collagen membrane will reduce treatment time by decreasing
      need for second surgery
Assessment of Guided Bone Regeneration in Atrophic Anterior Maxilla using native Collagen vs
      Titanium Reinforced Polytetraflouroethelene Membranes using an organic bovine Bone
      mineral.Reconstructive surgery is necessary before implant placement to regenerate bone
      defects caused by atrophy, dental trauma, extractions or periodontal disease . Success rate
      of implants is related to the correct position and angulation of implants in residual crest,
      so that height and thickness of bone augmentation can allow predictable results ,With this in
      mind, it is important to establish sound clinical concepts with clearly defined parameters
      that lead to successful esthetics in the anterior maxilla, with long-term stability of the
      peri-implant tissues.

      The most popular surgical procedures to obtain bone augmentation are: bone grafts, guided
      bone regeneration, maxillary sinus floor elevation, and bone osteogenesis distraction.

      Guided bone regeneration (GBR) is a surgical technique that uses barrier membranes to promote
      osteoblast cells proliferation and exclude other cells such as epithelium and connective
      tissue cells. GBR is often combined with bone grafting procedures.

      Bone grafts are integrated into native bone with three different processes: osteogenesis,
      osteoinduction and osteoconduction; Osteogenesis is the formation of new bone from
      osteocompetent cells and is the only process where the graft itself can induce Bone
      augmentation, Osteoinduction induces Bone Augmentation from the differentiation and
      stimulation of mesenchymal cells by the bone-inductive proteins, Osteoconduction is the
      formation of Bone Augmentation along a scaffold from osteocompetent cells of the recipient
      site .

      There are 2 Types of membranes:

      III. Non Resorbable membrane IV. Resorbable membrane

      Non-resorbable membranes:

      With the presentation of the ﬁrst successful GBR procedures and the subsequent wide and
      successful application of ePTFE membranes, this material became a standard for bone
      regeneration. Expanded PTFE is characterized as a polymer with high stability in biological
      systems. It resists breakdown by host tissues and by microbes and does not elicit immunologic
      reactions. A frequent complication with membrane application in conjunction with implants is
      membrane exposure and infection Wound dehiscence and membrane exposure have been reported to
      impair the amount of bone regenerated in a number of experimental animal and clinical
      investigations

      Bioresorbable membranes:

      The requirement of second surgical procedure for the removal of Non Resorbable barrier
      membrane(NRBM) led to the introduction of bioresorbable barrier membranes (RBM). The
      advantages of RBM compared to NRBM were as follows:

        1. Improved soft tissue healing,

        2. Incorporation of the membranes by the host tissues (depending on material properties),

        3. Quick resorption in case of exposure, eliminating bacterial contamination. Today, a lot
           of RBM are commercially available including collagen, freeze-dried fascia lata,
           freeze-dried dura mater allografts, polyglactin-acid, polylactic acid, polyglycolic
           acid, polyorthoester, polyurethane, polyhydroxybutyrate, etc.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Double (Participant, Outcomes Assessor)
masking description: Each patient will be given a code by the researcher ( T.A ) and the observer will be blind to which group this case belongs Patients,evaluators and statistican will be blinded
measure: Height and width of bone gained
time frame: After 6 monthes
description: Height and width of bone gained will be measured from CBCT
measure: Bone area percentage
time frame: After 6 monthes
description: Bone area percentage will be measured by Histo-morphometric analysis
arm group label: Ridge augmentation by collagen membrane
arm group type: Experimental
description: Intra operative procedures (for both groups) followed by CBCT will be taken for every patient.
Local anesthesia will be given to the patient.
Scrubbing and draping of the patient will be carried out in a standard fashion for intra oral procedures.
Flap will be done.
bone decortication will be done using surgical round bur, anorganic bovine bone derived mineral will be packed at defected area then covered at the defected area by a collagen membrane which will be stabilized by tacks.
The site will then be copiously irrigated with saline in preparation for closure.
The flap will then be closed using interrupted 4/0 resorbable sutures.
arm group label: augmentation by titanium reinforced PTFE
arm group type: Active Comparator
description: Intra operative procedures (for both groups) followed by CBCT will be taken for every patient.
Local anesthesia will be given to the patient.
Scrubbing and draping of the patient will be carried out in a standard fashion for intra oral procedures.
Flap will be done.
bone decortication will be done using surgical round bur, anorganic bovine bone derived mineral will be packed at the defected area then covered by a titanium reinforced polytetraflouroethelene membrane which will be stabilized by tacks.
The site will then be copiously irrigated with saline in preparation for closure.
The flap will then be closed using interrupted 4/0 resorbable sutures.
intervention type: Other
intervention name: Augmentation
description: non invasive technique to increase bone width and eliminate need for second surgery
arm group label: Ridge augmentation by collagen membrane
arm group label: augmentation by titanium reinforced PTFE
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
last name: Mohamed m Atef
role: Principal Investigator
affiliation: Cairo U
last name: Mohab f Metwally
phone: 00201115709990
email: hobaz90_2000@hotmail.com
citation: Lopez MA, Andreasi Bassi M, Confalone L, Carinci F. REGENERATION OF ATROPHIC CRESTAL RIDGES WITH RESORBABLE LAMINA: TECHNICAL NOTE. J Biol Regul Homeost Agents. 2015 Jul-Sep;29(3 Suppl 1):97-100.
PMID: 26511187
citation: Esposito M, Grusovin MG, Coulthard P, Worthington HV. The efficacy of various bone augmentation procedures for dental implants: a Cochrane systematic review of randomized controlled clinical trials. Int J Oral Maxillofac Implants. 2006 Sep-Oct;21(5):696-710.
PMID: 17066630
citation: Sorni M, Guarinos J, Garcia O, Penarrocha M. Implant rehabilitation of the atrophic upper jaw: a review of the literature since 1999. Med Oral Patol Oral Cir Bucal. 2005 Apr 1;10 Suppl 1:E45-56. English, Spanish.
PMID: 15800467
citation: Hoexter DL. Bone regeneration graft materials. J Oral Implantol. 2002;28(6):290-4. doi: 10.1563/1548-1336(2002)0282.3.CO;2.
PMID: 12498538
citation: Chiapasco M, Zaniboni M, Boisco M. Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants. Clin Oral Implants Res. 2006 Oct;17 Suppl 2:136-59. doi: 10.1111/j.1600-0501.2006.01357.x.
PMID: 16968389
citation: Karring T, Cortellini P, Lindhe J. Regenerative periodontal therapy. In: Lindhe J, Karring T, Lang NP, editors. Clinical periodontology and implant dentistry. Copenhagen: Munksgaard, 1997: 597-646.
citation: Schliephake H, Kracht D. Vertical ridge augmentation using polylactic membranes in conjunction with immediate implants in periodontally compromised extraction sites: an experimental study in dogs. Int J Oral Maxillofac Implants. 1997 May-Jun;12(3):325-34.
PMID: 9197097
citation: Gotfredsen K, Nimb L, Buser D, Hjorting-Hansen E. Evaluation of guided bone generation around implants placed into fresh extraction sockets: an experimental study in dogs. J Oral Maxillofac Surg. 1993 Aug;51(8):879-84; discussion 885-6. doi: 10.1016/s0278-2391(10)80108-9.
PMID: 8336225
citation: Kohal RJ, Trejo PM, Wirsching C, Hurzeler MB, Caffesse RG. Comparison of bioabsorbable and bioinert membranes for guided bone regeneration around non-submerged implants. An experimental study in the mongrel dog. Clin Oral Implants Res. 1999 Jun;10(3):226-37. doi: 10.1034/j.1600-0501.1999.100306.x.
PMID: 10522183
citation: Becker W, Dahlin C, Becker BE, Lekholm U, van Steenberghe D, Higuchi K, Kultje C. The use of e-PTFE barrier membranes for bone promotion around titanium implants placed into extraction sockets: a prospective multicenter study. Int J Oral Maxillofac Implants. 1994 Jan-Feb;9(1):31-40.
PMID: 8150510
citation: Gher ME, Quintero G, Assad D, Monaco E, Richardson AC. Bone grafting and guided bone regeneration for immediate dental implants in humans. J Periodontol. 1994 Sep;65(9):881-91. doi: 10.1902/jop.1994.65.9.881.
PMID: 7990026
citation: Elgali I, Omar O, Dahlin C, Thomsen P. Guided bone regeneration: materials and biological mechanisms revisited. Eur J Oral Sci. 2017 Oct;125(5):315-337. doi: 10.1111/eos.12364. Epub 2017 Aug 19.
PMID: 28833567
citation: McAllister BS, Haghighat K. Bone augmentation techniques. J Periodontol. 2007 Mar;78(3):377-96. doi: 10.1902/jop.2007.060048.
PMID: 17335361
citation: Hutmacher D, Hurzeler MB, Schliephake H. A review of material properties of biodegradable and bioresorbable polymers and devices for GTR and GBR applications. Int J Oral Maxillofac Implants. 1996 Sep-Oct;11(5):667-78.
PMID: 8908867
responsible party type: Principal Investigator
investigator affiliation: Cairo University
investigator full name: Mohab Fathy Metwally
investigator title: Master student
mesh term: Atrophy
sharing ipd: Undecided