<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03838757</url>
  </required_header>
  <id_info>
    <org_study_id>Gaziuniversity13</org_study_id>
    <nct_id>NCT03838757</nct_id>
  </id_info>
  <brief_title>Maximal Exercise Capacity and Extra-pulmonary Characteristics in Patients With Lung Cancer With Complete Remission .</brief_title>
  <official_title>Maximal Exercise Capacity, Extra-pulmonary Characteristics and Physical Activity Levels in Patients With Lung Cancer With Complete Remission .</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Gazi University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Gazi University</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      While lung cancer are rare disease in the early 20th century, its incidence increased in&#xD;
      parallel with the increase in smoking habits. It is the most common type of cancer in the&#xD;
      world. Despite advances in the efficacy of chemotherapy and radiotherapy regimens, surgical&#xD;
      resection is the most effective curative treatment modality to improve survival in non-small&#xD;
      cell lung cancer. Pulmonary resection candidates are selected according to not only tumor&#xD;
      type and stage, but also functional status, exercise capacity, underlying lung disorders and&#xD;
      health-related quality of life assessments. Patients with lung cancer often have lung and&#xD;
      heart comorbidities that affect the outcome of the outcome measures and restricts cancer&#xD;
      treatment options. In patients with lung cancer, shortness of breath, physical inactivity,&#xD;
      weakness in peripheral muscles and exercise intolerance are described. Pulmonary&#xD;
      rehabilitation is a multidisciplinary treatment designed to improve exercise capacity,&#xD;
      functional status, health-related quality of life and to reduce the attenuation of chronic&#xD;
      shortness of breath and fatigue in patients with chronic lung problems.&#xD;
&#xD;
      In literature, the effect of surgery in patients with lung cancer on postoperative&#xD;
      respiratory muscle strength is not clear. There is no study investigating the effect of&#xD;
      chemotherapy and radiotherapy on respiratory muscle strength. For these reasons, the aim of&#xD;
      the study was to evaluate the curative period of non-small cell lung cancer patients with&#xD;
      reliability and validity assessment methods. The hypothesis of our study was; when compared&#xD;
      with patients with lung cancer and healthy individuals, exercise capacity, respiratory and&#xD;
      peripheral muscle strength, physical activity levels, sleep and quality of life of lung&#xD;
      cancer patients are reduced; dyspnoea, fatigue, depression, cough and pain levels increase.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      According to sample size calculation 20 lung with complete remission cancer patients and 20&#xD;
      healthy individuals were included in the study. Cross-sectional observational research. The&#xD;
      demographic, physical and physiological characteristics were recorded from the patient files.&#xD;
      Exercise capacity (using cardiopulmonary exercise testing), physical activity, pulmonary&#xD;
      functions, respiratory and peripheral muscle strength, dyspnea and fatigue perception,&#xD;
      depression, cough, pain and quality of life were evaluated. Primary outcome measurement is&#xD;
      maximal exercise capacity. Secondary outcomes are respiratory and peripheral muscle strength,&#xD;
      pulmonary functions, physical activity, dyspnea and fatigue perception, depression, cough,&#xD;
      pain and quality of life.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">December 31, 2015</start_date>
  <completion_date type="Actual">February 2017</completion_date>
  <primary_completion_date type="Actual">February 2017</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Control</observational_model>
    <time_perspective>Other</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Maximal exercise capacity</measure>
    <time_frame>Second day</time_frame>
    <description>Cardiopulmonary exercise testing (Oxygen consumption measurement during test).</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Functional exercise capacity</measure>
    <time_frame>First day</time_frame>
    <description>The six-minute walking test (6-MWT) was used to evaluate submaximal exercise capacity.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Physical activity</measure>
    <time_frame>First day</time_frame>
    <description>Physical activity will be evaluated multi sensor activity monitor for 2 consecutive days.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pulmonary function test</measure>
    <time_frame>First day</time_frame>
    <description>This test was evaluated using a spirometry by which is evaluated dynamic lung functions expressed as percentages of expected values.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Inspiratory and Expiratory muscle strength (MIP, MEP)</measure>
    <time_frame>First day</time_frame>
    <description>Respiratory muscle strength was evaluated with a mouth pressure device</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peripheral muscle strength</measure>
    <time_frame>First day</time_frame>
    <description>Peripheral muscle strength was evaluated with a hand-held dynamometer.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Dyspnea</measure>
    <time_frame>First day</time_frame>
    <description>The severity of dyspnea during daily living activities was evaluated using the Modified Medical Research Council (MMRC) dyspnea scale. Dyspnea is graded as follows: zero (dyspnea only with strenuous exercise), one (dyspnea when hurrying or walking up a slight hill), two (walks slower than people of the same age due to dyspnea or having to stop for breath when walking at own pace), three (stops for breath after walking 100 yards or after a few minutes) and four (too dyspneic to leave house or breathless when dressing). The minimal clinically important difference (MCID) is 1 unit for the MMRC dyspnea scale.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Fatigue Severity</measure>
    <time_frame>First day</time_frame>
    <description>The Turkish version of Fatigue Severity Scale, which is a valid and reliable test, was performed to the recipients for evaluation of fatigue severity. Self-administered questionnaire is comprised of nine questions. The average score is identified on seven-point scale. Patients select a number from 1 to 7 for each 9 questions which demonstrates from strong disagreement to strong agreement, respectively. The cut-off score for fatigue severity is 36 according to this scale, if the total score obtained from this scale is higher than 36, the recipient is defined as severe fatigue.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Life Quality</measure>
    <time_frame>First day</time_frame>
    <description>Quality of life was measured using Turkish version of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 version 3.0 (EORTCQLQ) which is widely used as health related quality of life questionnaire in cancer patients. The cancer-specific questionnaire has 30 questions and incorporates five functional scales, three symptom scales, a global health status and several single items. All item scores are transformed to 0-100. Higher values indicate higher functional/healthy level in functional scales, a higher quality of life level in global health status and increased symptoms in symptom scales.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Depression</measure>
    <time_frame>First day</time_frame>
    <description>Montgomery Asberg Depression Rating Scale (MADRS) (Turkish version of scale) This assessment tool contains 10 items with a score from 0 to 6, thus the maximum score is 60. A higher score indicates a more severe depression.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Sleep of quality</measure>
    <time_frame>First day</time_frame>
    <description>Sleep quality of the individuals was evaluated with the Turkish version of Pittsburgh Sleep Quality Index. It is an individual evaluation scale that evaluates sleep quality and sleep disturbance in the last one month period.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cough</measure>
    <time_frame>First day</time_frame>
    <description>The Turkish version of the Leicester Cough Scale (LÖQ) was used to assess the health-related quality of life of individuals with chronic cough. The scale evaluates chronic cough consisting of 19 items, including physical (8 items), psychosocial (7 items) and social (4 items) subsections. Each item is scored between 1 (always) and 7 (never). The total score is 3-21 points. The high scores obtained from this questionnaire, which evaluates the effect of the symptoms that have been going on for the last two weeks, show less impact on cough and lower scores indicate more impact.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Life Quality</measure>
    <time_frame>Second day</time_frame>
    <description>Functional Assessment of Cancer Therapy - Lung cancer Quality of life questionnaire (Turkish version) is used to assess the quality of life of lung cancer patients from many cultures all over the world. It is an individual applied scale and consists of 36 questions specific to lung cancer. Body is a scale consisting of 5 subsections including status, social life and family situation, emotional state, activity status and other concerns.</description>
  </secondary_outcome>
  <number_of_groups>2</number_of_groups>
  <enrollment type="Actual">40</enrollment>
  <condition>Lung Cancer</condition>
  <arm_group>
    <arm_group_label>Patients</arm_group_label>
    <description>Maximal exercise capacity was assessed using cardiopulmonary exercise testing (CPET), exercise capacity six minute walk test, physical activity multi-sensor activity monitor, pulmonary function spirometry, respiratory muscle strength mouth pressure device, peripheral muscle strength hand held dynamometer, dyspnea Modified Medical Research Council Dyspnea Scale (MMRC), fatigue Fatigue Severity Scale, quality of life The European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30) and Functional Assessment of Cancer Therapy - Lung cancer quality of life questionnaire (FACT-L), depression Montgomery Asberg Depression scale, sleep of quality Pittsburgh Sleep Quality index and cough using Leicester Cough Questionnaire were evaluated.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Healthy controls</arm_group_label>
    <description>Maximal exercise capacity was assessed using cardiopulmonary exercise testing (CPET), exercise capacity six minute walk test, physical activity multi-sensor activity monitor, pulmonary function spirometry, respiratory muscle strength mouth pressure device, peripheral muscle strength hand held dynamometer, dyspnea Modified Medical Research Council Dyspnea Scale (MMRC), fatigue Fatigue Severity Scale, quality of life The European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30) and Functional Assessment of Cancer Therapy - Lung cancer quality of life questionnaire (FACT-L), depression Montgomery Asberg Depression scale, sleep of quality Pittsburgh Sleep Quality index and cough using Leicester Cough Questionnaire were evaluated.</description>
  </arm_group>
  <eligibility>
    <study_pop>
      <textblock>
        20 patients with lung cancer were included in the patients group and 20 healthy individuals&#xD;
        were included in the control group&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patients with; Diagnosed with lung cancer Stage 1, stage 2 and stage 3 patients in&#xD;
             lung cancer patients Clinically stable and Under standard medication patients were&#xD;
             included.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Patients with Metastasis Orthopedic and neurological problems Acute infection&#xD;
             Non-co-operable&#xD;
&#xD;
          -  Healthy Subjects with Any diagnosed disease were excluded.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>70 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Zeynep Pelin Dündar, MSc</last_name>
    <role>Study Chair</role>
    <affiliation>Gazi University</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Meral Boşnak Güçlü, Assoc. Prof</last_name>
    <role>Study Director</role>
    <affiliation>Gazi University</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Aydın Çiltaş, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Gebze Medical Park Hospital</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Mustafa Benekli, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Cukurambar/Ankara</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Gazi University Faculty of Health Sciences Department of Physical Therapy and Rehabilitation</name>
      <address>
        <city>Yenimahalle</city>
        <country>Turkey</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Turkey</country>
  </location_countries>
  <results_reference>
    <citation>Cavalheri V, Jenkins S, Cecins N, Gain K, Phillips M, Sanders LH, Hill K. Impairments after curative intent treatment for non-small cell lung cancer: a comparison with age and gender-matched healthy controls. Respir Med. 2015 Oct;109(10):1332-9. doi: 10.1016/j.rmed.2015.08.015. Epub 2015 Aug 29.</citation>
    <PMID>26342839</PMID>
  </results_reference>
  <results_reference>
    <citation>Granger CL, Denehy L, Parry SM, Martin J, Dimitriadis T, Sorohan M, Irving L. Which field walking test should be used to assess functional exercise capacity in lung cancer? An observational study. BMC Pulm Med. 2015 Aug 12;15:89. doi: 10.1186/s12890-015-0075-2.</citation>
    <PMID>26264470</PMID>
  </results_reference>
  <results_reference>
    <citation>Cavalheri V, Jenkins S, Cecins N, Gain K, Hill K. Comparison of the six-minute walk test with a cycle-based cardiopulmonary exercise test in people following curative intent treatment for non-small cell lung cancer. Chron Respir Dis. 2016 May;13(2):118-27. doi: 10.1177/1479972316631137. Epub 2016 Feb 11.</citation>
    <PMID>26869579</PMID>
  </results_reference>
  <results_reference>
    <citation>Granger CL, Parry SM, Edbrooke L, Denehy L. Deterioration in physical activity and function differs according to treatment type in non-small cell lung cancer - future directions for physiotherapy management. Physiotherapy. 2016 Sep;102(3):256-63. doi: 10.1016/j.physio.2015.10.007. Epub 2015 Oct 23.</citation>
    <PMID>26597694</PMID>
  </results_reference>
  <results_reference>
    <citation>Arbane G, Douiri A, Hart N, Hopkinson NS, Singh S, Speed C, Valladares B, Garrod R. Effect of postoperative physical training on activity after curative surgery for non-small cell lung cancer: a multicentre randomised controlled trial. Physiotherapy. 2014 Jun;100(2):100-7. doi: 10.1016/j.physio.2013.12.002. Epub 2014 Feb 12.</citation>
    <PMID>24703523</PMID>
  </results_reference>
  <results_reference>
    <citation>Hashmi A, Baciewicz FA Jr, Soubani AO, Gadgeel SM. Preoperative pulmonary rehabilitation for marginal-function lung cancer patients. Asian Cardiovasc Thorac Ann. 2017 Jan;25(1):47-51. doi: 10.1177/0218492316683757. Epub 2016 Dec 5.</citation>
    <PMID>27913735</PMID>
  </results_reference>
  <verification_date>February 2019</verification_date>
  <study_first_submitted>February 11, 2019</study_first_submitted>
  <study_first_submitted_qc>February 11, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">February 12, 2019</study_first_posted>
  <last_update_submitted>February 11, 2019</last_update_submitted>
  <last_update_submitted_qc>February 11, 2019</last_update_submitted_qc>
  <last_update_posted type="Actual">February 12, 2019</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Gazi University</investigator_affiliation>
    <investigator_full_name>Meral Boşnak Güçlü</investigator_full_name>
    <investigator_title>Associate Professor</investigator_title>
  </responsible_party>
  <keyword>Lung cancer</keyword>
  <keyword>Exercise capacity</keyword>
  <keyword>Cardiopulmonary exercise test</keyword>
  <keyword>Respiratory muscle strength</keyword>
  <keyword>Physical activity</keyword>
  <keyword>Pulmonary functions</keyword>
  <keyword>Peripheral Muscle Strength</keyword>
  <keyword>Quality of life</keyword>
  <keyword>Sleep of quality</keyword>
  <keyword>Dyspnea</keyword>
  <keyword>Depression</keyword>
  <keyword>Fatigue</keyword>
  <keyword>Cough</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Lung Neoplasms</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03838757
org study id: Gaziuniversity13
nct id: NCT03838757
lead sponsor: 
is fda regulated drug: No
is fda regulated device: No
While lung cancer are rare disease in the early 20th century, its incidence increased in
      parallel with the increase in smoking habits. It is the most common type of cancer in the
      world. Despite advances in the efficacy of chemotherapy and radiotherapy regimens, surgical
      resection is the most effective curative treatment modality to improve survival in non-small
      cell lung cancer. Pulmonary resection candidates are selected according to not only tumor
      type and stage, but also functional status, exercise capacity, underlying lung disorders and
      health-related quality of life assessments. Patients with lung cancer often have lung and
      heart comorbidities that affect the outcome of the outcome measures and restricts cancer
      treatment options. In patients with lung cancer, shortness of breath, physical inactivity,
      weakness in peripheral muscles and exercise intolerance are described. Pulmonary
      rehabilitation is a multidisciplinary treatment designed to improve exercise capacity,
      functional status, health-related quality of life and to reduce the attenuation of chronic
      shortness of breath and fatigue in patients with chronic lung problems.

      In literature, the effect of surgery in patients with lung cancer on postoperative
      respiratory muscle strength is not clear. There is no study investigating the effect of
      chemotherapy and radiotherapy on respiratory muscle strength. For these reasons, the aim of
      the study was to evaluate the curative period of non-small cell lung cancer patients with
      reliability and validity assessment methods. The hypothesis of our study was; when compared
      with patients with lung cancer and healthy individuals, exercise capacity, respiratory and
      peripheral muscle strength, physical activity levels, sleep and quality of life of lung
      cancer patients are reduced; dyspnoea, fatigue, depression, cough and pain levels increase.
According to sample size calculation 20 lung with complete remission cancer patients and 20
      healthy individuals were included in the study. Cross-sectional observational research. The
      demographic, physical and physiological characteristics were recorded from the patient files.
      Exercise capacity (using cardiopulmonary exercise testing), physical activity, pulmonary
      functions, respiratory and peripheral muscle strength, dyspnea and fatigue perception,
      depression, cough, pain and quality of life were evaluated. Primary outcome measurement is
      maximal exercise capacity. Secondary outcomes are respiratory and peripheral muscle strength,
      pulmonary functions, physical activity, dyspnea and fatigue perception, depression, cough,
      pain and quality of life.
observational model: Case-Control
time perspective: Other
measure: Maximal exercise capacity
time frame: Second day
description: Cardiopulmonary exercise testing (Oxygen consumption measurement during test).
measure: Functional exercise capacity
time frame: First day
description: The six-minute walking test (6-MWT) was used to evaluate submaximal exercise capacity.
measure: Physical activity
time frame: First day
description: Physical activity will be evaluated multi sensor activity monitor for 2 consecutive days.
measure: Pulmonary function test
time frame: First day
description: This test was evaluated using a spirometry by which is evaluated dynamic lung functions expressed as percentages of expected values.
measure: Inspiratory and Expiratory muscle strength (MIP, MEP)
time frame: First day
description: Respiratory muscle strength was evaluated with a mouth pressure device
measure: Peripheral muscle strength
time frame: First day
description: Peripheral muscle strength was evaluated with a hand-held dynamometer.
measure: Dyspnea
time frame: First day
description: The severity of dyspnea during daily living activities was evaluated using the Modified Medical Research Council (MMRC) dyspnea scale. Dyspnea is graded as follows: zero (dyspnea only with strenuous exercise), one (dyspnea when hurrying or walking up a slight hill), two (walks slower than people of the same age due to dyspnea or having to stop for breath when walking at own pace), three (stops for breath after walking 100 yards or after a few minutes) and four (too dyspneic to leave house or breathless when dressing). The minimal clinically important difference (MCID) is 1 unit for the MMRC dyspnea scale.
measure: Fatigue Severity
time frame: First day
description: The Turkish version of Fatigue Severity Scale, which is a valid and reliable test, was performed to the recipients for evaluation of fatigue severity. Self-administered questionnaire is comprised of nine questions. The average score is identified on seven-point scale. Patients select a number from 1 to 7 for each 9 questions which demonstrates from strong disagreement to strong agreement, respectively. The cut-off score for fatigue severity is 36 according to this scale, if the total score obtained from this scale is higher than 36, the recipient is defined as severe fatigue.
measure: Life Quality
time frame: First day
description: Quality of life was measured using Turkish version of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 version 3.0 (EORTCQLQ) which is widely used as health related quality of life questionnaire in cancer patients. The cancer-specific questionnaire has 30 questions and incorporates five functional scales, three symptom scales, a global health status and several single items. All item scores are transformed to 0-100. Higher values indicate higher functional/healthy level in functional scales, a higher quality of life level in global health status and increased symptoms in symptom scales.
measure: Depression
time frame: First day
description: Montgomery Asberg Depression Rating Scale (MADRS) (Turkish version of scale) This assessment tool contains 10 items with a score from 0 to 6, thus the maximum score is 60. A higher score indicates a more severe depression.
measure: Sleep of quality
time frame: First day
description: Sleep quality of the individuals was evaluated with the Turkish version of Pittsburgh Sleep Quality Index. It is an individual evaluation scale that evaluates sleep quality and sleep disturbance in the last one month period.
measure: Cough
time frame: First day
description: The Turkish version of the Leicester Cough Scale (LÖQ) was used to assess the health-related quality of life of individuals with chronic cough. The scale evaluates chronic cough consisting of 19 items, including physical (8 items), psychosocial (7 items) and social (4 items) subsections. Each item is scored between 1 (always) and 7 (never). The total score is 3-21 points. The high scores obtained from this questionnaire, which evaluates the effect of the symptoms that have been going on for the last two weeks, show less impact on cough and lower scores indicate more impact.
measure: Life Quality
time frame: Second day
description: Functional Assessment of Cancer Therapy - Lung cancer Quality of life questionnaire (Turkish version) is used to assess the quality of life of lung cancer patients from many cultures all over the world. It is an individual applied scale and consists of 36 questions specific to lung cancer. Body is a scale consisting of 5 subsections including status, social life and family situation, emotional state, activity status and other concerns.
arm group label: Patients
description: Maximal exercise capacity was assessed using cardiopulmonary exercise testing (CPET), exercise capacity six minute walk test, physical activity multi-sensor activity monitor, pulmonary function spirometry, respiratory muscle strength mouth pressure device, peripheral muscle strength hand held dynamometer, dyspnea Modified Medical Research Council Dyspnea Scale (MMRC), fatigue Fatigue Severity Scale, quality of life The European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30) and Functional Assessment of Cancer Therapy - Lung cancer quality of life questionnaire (FACT-L), depression Montgomery Asberg Depression scale, sleep of quality Pittsburgh Sleep Quality index and cough using Leicester Cough Questionnaire were evaluated.
arm group label: Healthy controls
description: Maximal exercise capacity was assessed using cardiopulmonary exercise testing (CPET), exercise capacity six minute walk test, physical activity multi-sensor activity monitor, pulmonary function spirometry, respiratory muscle strength mouth pressure device, peripheral muscle strength hand held dynamometer, dyspnea Modified Medical Research Council Dyspnea Scale (MMRC), fatigue Fatigue Severity Scale, quality of life The European Organization for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30) and Functional Assessment of Cancer Therapy - Lung cancer quality of life questionnaire (FACT-L), depression Montgomery Asberg Depression scale, sleep of quality Pittsburgh Sleep Quality index and cough using Leicester Cough Questionnaire were evaluated.
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: 70 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Zeynep Pelin Dündar, MSc
role: Study Chair
affiliation: Gazi University
last name: Meral Boşnak Güçlü, Assoc. Prof
role: Study Director
affiliation: Gazi University
last name: Aydın Çiltaş, MD
role: Principal Investigator
affiliation: Gebze Medical Park Hospital
last name: Mustafa Benekli, MD
role: Principal Investigator
affiliation: Cukurambar/Ankara
facility: 
country: Turkey
citation: Cavalheri V, Jenkins S, Cecins N, Gain K, Phillips M, Sanders LH, Hill K. Impairments after curative intent treatment for non-small cell lung cancer: a comparison with age and gender-matched healthy controls. Respir Med. 2015 Oct;109(10):1332-9. doi: 10.1016/j.rmed.2015.08.015. Epub 2015 Aug 29.
PMID: 26342839
citation: Granger CL, Denehy L, Parry SM, Martin J, Dimitriadis T, Sorohan M, Irving L. Which field walking test should be used to assess functional exercise capacity in lung cancer? An observational study. BMC Pulm Med. 2015 Aug 12;15:89. doi: 10.1186/s12890-015-0075-2.
PMID: 26264470
citation: Cavalheri V, Jenkins S, Cecins N, Gain K, Hill K. Comparison of the six-minute walk test with a cycle-based cardiopulmonary exercise test in people following curative intent treatment for non-small cell lung cancer. Chron Respir Dis. 2016 May;13(2):118-27. doi: 10.1177/1479972316631137. Epub 2016 Feb 11.
PMID: 26869579
citation: Granger CL, Parry SM, Edbrooke L, Denehy L. Deterioration in physical activity and function differs according to treatment type in non-small cell lung cancer - future directions for physiotherapy management. Physiotherapy. 2016 Sep;102(3):256-63. doi: 10.1016/j.physio.2015.10.007. Epub 2015 Oct 23.
PMID: 26597694
citation: Arbane G, Douiri A, Hart N, Hopkinson NS, Singh S, Speed C, Valladares B, Garrod R. Effect of postoperative physical training on activity after curative surgery for non-small cell lung cancer: a multicentre randomised controlled trial. Physiotherapy. 2014 Jun;100(2):100-7. doi: 10.1016/j.physio.2013.12.002. Epub 2014 Feb 12.
PMID: 24703523
citation: Hashmi A, Baciewicz FA Jr, Soubani AO, Gadgeel SM. Preoperative pulmonary rehabilitation for marginal-function lung cancer patients. Asian Cardiovasc Thorac Ann. 2017 Jan;25(1):47-51. doi: 10.1177/0218492316683757. Epub 2016 Dec 5.
PMID: 27913735
responsible party type: Principal Investigator
investigator affiliation: Gazi University
investigator full name: Meral Boşnak Güçlü
investigator title: Associate Professor
mesh term: Lung Neoplasms