<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03836820</url>
  </required_header>
  <id_info>
    <org_study_id>436</org_study_id>
    <nct_id>NCT03836820</nct_id>
  </id_info>
  <brief_title>Effects of Clinical Pilates Exercises in Patients With Rheumatoid Arthritis</brief_title>
  <official_title>Effects of Clinical Pilates Exercises in Patients With Rheumatoid Arthritis</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Gazi University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Gazi University</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by polyarthritis&#xD;
      and erosive synovitis. Articular and extraarticular sympthoms are mostly seen in patients&#xD;
      with RA. Additionally, extra complaints such as depression, fatigue, kinesiophobia and&#xD;
      physical inactivity may accompany. Positive effects of physical activity and exercise are&#xD;
      known. In some studies, effects of pilates exercises have been investigated on many different&#xD;
      diseases such as Multiple Sclerosis, Ankylosing Spondylitis and breast cancer. The aim of&#xD;
      this study is to investigate effects of clinical pilates exercises on fatigue, depression,&#xD;
      aerobic capacity, pain, quality of life, disease activity and sleep quality.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by polyarthritis&#xD;
      and erosive synovitis and is associated with progressive impairments and activity&#xD;
      limitations. It may cause destruction of bone and cartilage by affecting synovial joints&#xD;
      symmetrically. Organ involvement may be seen in the patients with RA as well as joint&#xD;
      involvement. Initiation of the disease is mostly insidious and varies from patient to&#xD;
      patient. Hand, wrist, foot, elbow and knee joints involvement are common. Furthermore almost&#xD;
      all joints may be affected. Extraarticular symptoms are subcutaneous nodules, visceral&#xD;
      nodules, cardiologic involvement, pulmonary involvement, eye involvement, neurological&#xD;
      involvement, vasculitis, felty syndrome, amyloidosis, osteoporosis, liver and renal&#xD;
      involvements. These symptoms may cause some extra complaints such as depression, fatigue,&#xD;
      kinesiophobia and physical inactivity. Studies in literature have reported reduction in&#xD;
      physical activity level in patients with RA. Reasons of physical inactivity can be listed as&#xD;
      general obstacles such as lack of time, lack of motivation, weather condition and disease&#xD;
      related blocks such as pain, fatigue, disease activity, depression, kinesiophobia. Depression&#xD;
      prevalence in RA patients is found between 14.8% and 38.8% and this rate is estimated five&#xD;
      times more than healthy people. Also, a study investigating pain in RA patients resulted that&#xD;
      pain may be correlated with fatigue and depression. Fatigue which is frequently observed&#xD;
      complaint of patients with rheumatic diseases is reported incidence between 40% and 80%. RA&#xD;
      patients have been reported at high risk for cardiovascular diseases in EULAR&#xD;
      recommendations.&#xD;
&#xD;
      Positive effects of physical activity and exercise on physiological, morphological and&#xD;
      psychosocial conditions are known. Endurance, flexibility, muscle strength, body composition,&#xD;
      self confidence and mood improve by regular exercise and high physical activity level.&#xD;
      Furthermore, anti-inflammatory affects of exercise are proved in last years. Aims of pilates&#xD;
      exercises which are developed by Joseph Pilates are to increase motor control, range of&#xD;
      motion, flexibility, muscle strength and endurance, to improve balance, respiratory pattern&#xD;
      and body awareness, to reduce stress. There are many studies investigating affects of pilates&#xD;
      exercises on quality of life, functional capacity, posture, pain for different diseases&#xD;
      including Multiple Sclerosis, Ankylosing Spondylitis, breast cancer. Aerobic and&#xD;
      strengthening exercises reported to have positive affects on fatigue, quality of life,&#xD;
      depression and pain for RA patients. The aim of this study is to investigate effects of&#xD;
      clinical pilates exercises on fatigue, depression, aerobic capacity, pain, quality of life,&#xD;
      disease activity and sleep quality.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">December 24, 2018</start_date>
  <completion_date type="Anticipated">October 2019</completion_date>
  <primary_completion_date type="Anticipated">July 2019</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Aerobic capacity</measure>
    <time_frame>6 minutes</time_frame>
    <description>The 6-minute walk test is a submaximal exercise test used to quantify the functional exercise capacity in clinical populations. It measures the distance walked within a period of 6-minutes.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Fatigue severity scale</measure>
    <time_frame>2 minutes</time_frame>
    <description>Fatigue is a normal response to physical exertion or stress but can also be a sign of a physical disorder. In the common sense, fatigue is a condition known to everyone from his or her own experience,irrespective of his or her age, gender, or health. Fatigue severity scale consists of nine questions; each question is scored from 1 to 7</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Beck Depression Inventory</measure>
    <time_frame>2 minutes</time_frame>
    <description>The Beck Depression Inventory (BDI) is world-wide among the most used selfrating scales for measuring depression. BDI consists of 21 items related to depressive symptoms such as pessimism, sense of failure, guilt, dissatisfaction, sleep, appetite and fatigue. Each item is scored between 0 and 3. Total score is 63, and an increase of the score means increased severity of depression. According to this scale 1-10 points are defined as normal, scores between 11-16 indicate mild mental distress, 17-20 indicate the patient is at the border points for clinical depression, 21-30 indicate moderate depression, severe depression scores are between 31-40 and 40 points above are interpreted as a very serious depression.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Short Form McGill Pain Questionnaire</measure>
    <time_frame>1 minute</time_frame>
    <description>This questionnaire consists of 11 sensory and 4 affective descriptive words. These 15 words are described as 0 = absent, 1 = mild, 2 = moderate, 3 = severe pain. So three type of pain scores (sensory, affective, total = sensory + affective) are obtained. In McGill Pain Questionnaire, the current level of pain is measured by Visual Analog Scale (VAS) and Likert scale consisting of 6 points (0 = no pain, 1 = mild, 2 = irritating, 3 = bothersome, 4 = terrible, 5 = unbearable).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pittsburgh Sleep Quality</measure>
    <time_frame>2 minutes</time_frame>
    <description>The Pittsburgh Sleep Quality Index (PSQI) is a self-rated questionnaire which assesses sleep quality and disturbances over a 1-month time interval. Nineteen individual items generate seven &quot;component&quot; scores: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. The sum of scores for these seven components yields one global score.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Disease Activity Score- 28</measure>
    <time_frame>10 minutes</time_frame>
    <description>Disease Activity Score (DAS) is an assessment tool used to measure the level of disease activity in patients with RA. The DAS combines information from swollen joints, tender joints, erythrocyte sedimentation rate (ESR), and patient self-report of general health</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>The Rheumatoid Arthritis Quality of Life Questionnaire</measure>
    <time_frame>2 minutes</time_frame>
    <description>The Rheumatoid Arthritis Quality of Life (RAQoL) questionnaire is a disease-specific quality of life measure that was developed simultaneously in the UK and the Netherlands. The content of the RAQoL was derived from in-depth qualitative interviews with RA patients exploring.&#xD;
the impact of RA on their QoL.</description>
  </secondary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Anticipated">30</enrollment>
  <condition>Rheumatoid Arthritis</condition>
  <arm_group>
    <arm_group_label>Clinical pilates exercise</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Clinical pilates exercises will be performed three days in a week. Treatment will continue an hour in per session for 8 weeks.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Aerobic exercise</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Progressive aerobic walking exercise will be performed three days in a week. Exercise intensity will be 50- 80% of maximal heart rate and exercises will be performed 45 minutes in per session for 8 weeks.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Clinical pilates and Aerobic exercise</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Both clinical pilates exercises and progressive aerobic walking exercises will be performed three days in a week for 8 weeks.</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Clinical pilates exercise</intervention_name>
    <description>Clinical pilates exercises will be performed three days in a week. Treatment will continue an hour in per session for 8 weeks.</description>
    <arm_group_label>Clinical pilates and Aerobic exercise</arm_group_label>
    <arm_group_label>Clinical pilates exercise</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Aerobic exercise</intervention_name>
    <description>Progressive aerobic walking exercise will be performed three days in a week. Exercise intensity will be 50- 80% of maximal heart rate and exercises will be performed 45 minutes in per session for 8 weeks.</description>
    <arm_group_label>Aerobic exercise</arm_group_label>
    <arm_group_label>Clinical pilates and Aerobic exercise</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Clinical Pilates and Aerobic Exercise</intervention_name>
    <description>Both clinical pilates exercises and progressive aerobic walking exercises will be performed three days in a week for 8 weeks.</description>
    <arm_group_label>Aerobic exercise</arm_group_label>
    <arm_group_label>Clinical pilates and Aerobic exercise</arm_group_label>
    <arm_group_label>Clinical pilates exercise</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patients between the ages of 18 to 65 and who have diagnosed with RA according to&#xD;
             American College of Rheumatology criteria will be included the study.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Patients who were pregnant, diagnosed with malignancy, had changes of medical&#xD;
             treatment in the last 3 months, had dysfunction that limited physical activity such as&#xD;
             severe neurological impairment, immobility or cooperation deficits, had regular&#xD;
             exercise habit (minimally three days in a week), had high disease activity score&#xD;
             (DAS-28&gt;3.2) and had cardiac symphtoms according to New YorkHeart Association will be&#xD;
             excluded from the study.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>65 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Deran Oskay</last_name>
    <role>Study Director</role>
    <affiliation>Gazi University Faculty of Health Sciences</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Songul Baglan Yentur</last_name>
    <phone>+90 312 216 26 12</phone>
    <email>songulbaglan23@hotmail.com</email>
  </overall_contact>
  <location>
    <facility>
      <name>Gazi University</name>
      <address>
        <city>Ankara</city>
        <zip>06560</zip>
        <country>Turkey</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Songul Baglan Yentur</last_name>
    </contact>
    <investigator>
      <last_name>Nuh Atas</last_name>
      <role>Sub-Investigator</role>
    </investigator>
    <investigator>
      <last_name>Mehmet Akif Ozturk</last_name>
      <role>Sub-Investigator</role>
    </investigator>
    <investigator>
      <last_name>Deran Oskay</last_name>
      <role>Sub-Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>Turkey</country>
  </location_countries>
  <results_reference>
    <citation>Munsterman T, Takken T, Wittink H. Are persons with rheumatoid arthritis deconditioned? A review of physical activity and aerobic capacity. BMC Musculoskelet Disord. 2012 Oct 18;13:202. doi: 10.1186/1471-2474-13-202.</citation>
    <PMID>23078261</PMID>
  </results_reference>
  <results_reference>
    <citation>Rongen-van Dartel SA, Repping-Wuts H, Flendrie M, Bleijenberg G, Metsios GS, van den Hout WB, van den Ende CH, Neuberger G, Reid A, van Riel PL, Fransen J. Effect of Aerobic Exercise Training on Fatigue in Rheumatoid Arthritis: A Meta-Analysis. Arthritis Care Res (Hoboken). 2015 Aug;67(8):1054-62. doi: 10.1002/acr.22561.</citation>
    <PMID>25624016</PMID>
  </results_reference>
  <verification_date>February 2019</verification_date>
  <study_first_submitted>February 6, 2019</study_first_submitted>
  <study_first_submitted_qc>February 8, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">February 11, 2019</study_first_posted>
  <last_update_submitted>February 8, 2019</last_update_submitted>
  <last_update_submitted_qc>February 8, 2019</last_update_submitted_qc>
  <last_update_posted type="Actual">February 11, 2019</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Gazi University</investigator_affiliation>
    <investigator_full_name>Songul Baglan Yentur</investigator_full_name>
    <investigator_title>Research Assistant</investigator_title>
  </responsible_party>
  <keyword>Rheumatoid Arhritis</keyword>
  <keyword>Pilates exercises</keyword>
  <keyword>Fatigue</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Arthritis</mesh_term>
    <mesh_term>Arthritis, Rheumatoid</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03836820
org study id: 436
nct id: NCT03836820
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by polyarthritis
      and erosive synovitis. Articular and extraarticular sympthoms are mostly seen in patients
      with RA. Additionally, extra complaints such as depression, fatigue, kinesiophobia and
      physical inactivity may accompany. Positive effects of physical activity and exercise are
      known. In some studies, effects of pilates exercises have been investigated on many different
      diseases such as Multiple Sclerosis, Ankylosing Spondylitis and breast cancer. The aim of
      this study is to investigate effects of clinical pilates exercises on fatigue, depression,
      aerobic capacity, pain, quality of life, disease activity and sleep quality.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by polyarthritis
      and erosive synovitis and is associated with progressive impairments and activity
      limitations. It may cause destruction of bone and cartilage by affecting synovial joints
      symmetrically. Organ involvement may be seen in the patients with RA as well as joint
      involvement. Initiation of the disease is mostly insidious and varies from patient to
      patient. Hand, wrist, foot, elbow and knee joints involvement are common. Furthermore almost
      all joints may be affected. Extraarticular symptoms are subcutaneous nodules, visceral
      nodules, cardiologic involvement, pulmonary involvement, eye involvement, neurological
      involvement, vasculitis, felty syndrome, amyloidosis, osteoporosis, liver and renal
      involvements. These symptoms may cause some extra complaints such as depression, fatigue,
      kinesiophobia and physical inactivity. Studies in literature have reported reduction in
      physical activity level in patients with RA. Reasons of physical inactivity can be listed as
      general obstacles such as lack of time, lack of motivation, weather condition and disease
      related blocks such as pain, fatigue, disease activity, depression, kinesiophobia. Depression
      prevalence in RA patients is found between 14.8% and 38.8% and this rate is estimated five
      times more than healthy people. Also, a study investigating pain in RA patients resulted that
      pain may be correlated with fatigue and depression. Fatigue which is frequently observed
      complaint of patients with rheumatic diseases is reported incidence between 40% and 80%. RA
      patients have been reported at high risk for cardiovascular diseases in EULAR
      recommendations.

      Positive effects of physical activity and exercise on physiological, morphological and
      psychosocial conditions are known. Endurance, flexibility, muscle strength, body composition,
      self confidence and mood improve by regular exercise and high physical activity level.
      Furthermore, anti-inflammatory affects of exercise are proved in last years. Aims of pilates
      exercises which are developed by Joseph Pilates are to increase motor control, range of
      motion, flexibility, muscle strength and endurance, to improve balance, respiratory pattern
      and body awareness, to reduce stress. There are many studies investigating affects of pilates
      exercises on quality of life, functional capacity, posture, pain for different diseases
      including Multiple Sclerosis, Ankylosing Spondylitis, breast cancer. Aerobic and
      strengthening exercises reported to have positive affects on fatigue, quality of life,
      depression and pain for RA patients. The aim of this study is to investigate effects of
      clinical pilates exercises on fatigue, depression, aerobic capacity, pain, quality of life,
      disease activity and sleep quality.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Single (Outcomes Assessor)
measure: Aerobic capacity
time frame: 6 minutes
description: The 6-minute walk test is a submaximal exercise test used to quantify the functional exercise capacity in clinical populations. It measures the distance walked within a period of 6-minutes.
measure: Fatigue severity scale
time frame: 2 minutes
description: Fatigue is a normal response to physical exertion or stress but can also be a sign of a physical disorder. In the common sense, fatigue is a condition known to everyone from his or her own experience,irrespective of his or her age, gender, or health. Fatigue severity scale consists of nine questions; each question is scored from 1 to 7
measure: Beck Depression Inventory
time frame: 2 minutes
description: The Beck Depression Inventory (BDI) is world-wide among the most used selfrating scales for measuring depression. BDI consists of 21 items related to depressive symptoms such as pessimism, sense of failure, guilt, dissatisfaction, sleep, appetite and fatigue. Each item is scored between 0 and 3. Total score is 63, and an increase of the score means increased severity of depression. According to this scale 1-10 points are defined as normal, scores between 11-16 indicate mild mental distress, 17-20 indicate the patient is at the border points for clinical depression, 21-30 indicate moderate depression, severe depression scores are between 31-40 and 40 points above are interpreted as a very serious depression.
measure: Short Form McGill Pain Questionnaire
time frame: 1 minute
description: This questionnaire consists of 11 sensory and 4 affective descriptive words. These 15 words are described as 0 = absent, 1 = mild, 2 = moderate, 3 = severe pain. So three type of pain scores (sensory, affective, total = sensory + affective) are obtained. In McGill Pain Questionnaire, the current level of pain is measured by Visual Analog Scale (VAS) and Likert scale consisting of 6 points (0 = no pain, 1 = mild, 2 = irritating, 3 = bothersome, 4 = terrible, 5 = unbearable).
measure: Pittsburgh Sleep Quality
time frame: 2 minutes
description: The Pittsburgh Sleep Quality Index (PSQI) is a self-rated questionnaire which assesses sleep quality and disturbances over a 1-month time interval. Nineteen individual items generate seven "component" scores: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. The sum of scores for these seven components yields one global score.
measure: Disease Activity Score- 28
time frame: 10 minutes
description: Disease Activity Score (DAS) is an assessment tool used to measure the level of disease activity in patients with RA. The DAS combines information from swollen joints, tender joints, erythrocyte sedimentation rate (ESR), and patient self-report of general health
measure: The Rheumatoid Arthritis Quality of Life Questionnaire
time frame: 2 minutes
description: The Rheumatoid Arthritis Quality of Life (RAQoL) questionnaire is a disease-specific quality of life measure that was developed simultaneously in the UK and the Netherlands. The content of the RAQoL was derived from in-depth qualitative interviews with RA patients exploring.
the impact of RA on their QoL.
arm group label: Clinical pilates exercise
arm group type: Experimental
description: Clinical pilates exercises will be performed three days in a week. Treatment will continue an hour in per session for 8 weeks.
arm group label: Aerobic exercise
arm group type: Experimental
description: Progressive aerobic walking exercise will be performed three days in a week. Exercise intensity will be 50- 80% of maximal heart rate and exercises will be performed 45 minutes in per session for 8 weeks.
arm group label: Clinical pilates and Aerobic exercise
arm group type: Experimental
description: Both clinical pilates exercises and progressive aerobic walking exercises will be performed three days in a week for 8 weeks.
intervention type: Other
intervention name: Clinical pilates exercise
description: Clinical pilates exercises will be performed three days in a week. Treatment will continue an hour in per session for 8 weeks.
arm group label: Clinical pilates and Aerobic exercise
arm group label: Clinical pilates exercise
intervention type: Other
intervention name: Aerobic exercise
description: Progressive aerobic walking exercise will be performed three days in a week. Exercise intensity will be 50- 80% of maximal heart rate and exercises will be performed 45 minutes in per session for 8 weeks.
arm group label: Aerobic exercise
arm group label: Clinical pilates and Aerobic exercise
intervention type: Other
intervention name: Clinical Pilates and Aerobic Exercise
description: Both clinical pilates exercises and progressive aerobic walking exercises will be performed three days in a week for 8 weeks.
arm group label: Aerobic exercise
arm group label: Clinical pilates and Aerobic exercise
arm group label: Clinical pilates exercise
criteria: 
gender: All
minimum age: 18 Years
maximum age: 65 Years
healthy volunteers: No
last name: Deran Oskay
role: Study Director
affiliation: Gazi University Faculty of Health Sciences
last name: Songul Baglan Yentur
phone: +90 312 216 26 12
email: songulbaglan23@hotmail.com
facility: 
status: Recruiting
contact: 
investigator: 
investigator: 
investigator: 
country: Turkey
citation: Munsterman T, Takken T, Wittink H. Are persons with rheumatoid arthritis deconditioned? A review of physical activity and aerobic capacity. BMC Musculoskelet Disord. 2012 Oct 18;13:202. doi: 10.1186/1471-2474-13-202.
PMID: 23078261
citation: Rongen-van Dartel SA, Repping-Wuts H, Flendrie M, Bleijenberg G, Metsios GS, van den Hout WB, van den Ende CH, Neuberger G, Reid A, van Riel PL, Fransen J. Effect of Aerobic Exercise Training on Fatigue in Rheumatoid Arthritis: A Meta-Analysis. Arthritis Care Res (Hoboken). 2015 Aug;67(8):1054-62. doi: 10.1002/acr.22561.
PMID: 25624016
responsible party type: Principal Investigator
investigator affiliation: Gazi University
investigator full name: Songul Baglan Yentur
investigator title: Research Assistant
mesh term: Arthritis
mesh term: Arthritis, Rheumatoid
sharing ipd: No