<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03778658</url>
  </required_header>
  <id_info>
    <org_study_id>STUDY00010118</org_study_id>
    <nct_id>NCT03778658</nct_id>
  </id_info>
  <brief_title>Utilizing Novel Information Technology to Promote Exercise and Well-Being in Adolescents and Young Adults With Cancer</brief_title>
  <acronym>AYA-UNITE</acronym>
  <official_title>AYA-UNITE (Utilizing Novel Information Technology to Promote Exercise and Well-Being)</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Milton S. Hershey Medical Center</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Milton S. Hershey Medical Center</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Adolescents and young adults (AYAs) with cancer have many needs for supportive care that&#xD;
      differ from younger and older patients.This includes age-appropriate psychological support&#xD;
      for management of distress, as well as supports for the social isolation many AYAs&#xD;
      experience. One intervention that may provide AYAs with cancer improved psychosocial support,&#xD;
      as well as increased physical strength, is physical activity. This feasibility project aims&#xD;
      to evaluate the safety, feasibility and acceptability of a physical activity training in AYAs&#xD;
      with cancer delivered via a socially interactive videoconferencing platform.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Adolescents and young adults (AYAs) with cancer comprise a unique population within the&#xD;
      larger cancer community. This is primarily due to distinct differences in disease biology&#xD;
      compared to older and younger patients, as well as their unique psychosocial needs. AYAs with&#xD;
      cancer historically have unmet needs relating to management of their mental health and&#xD;
      treatment-related symptoms. One particular area of unmet need is distress management during&#xD;
      cancer treatment, reported in nearly one third of AYAs with newly diagnosed cancer. Reasons&#xD;
      for distress are multifactorial, including lack of medical information, worries about future&#xD;
      life goals and fertility, and social isolation from peers and family. Proactively addressing&#xD;
      and preventing this distress is critical for forestalling the high rates of depression,&#xD;
      anxiety, and post-traumatic stress seen in AYAs. One promising but under explored&#xD;
      intervention with the potential to mitigate distress is group-based physical activity.&#xD;
      Multiple studies cite physical activity's benefits for patients with cancer, while oncology&#xD;
      and sports medicine societies recommend including physical activity as part of comprehensive&#xD;
      cancer care. Group physical activity intervention models have been successful in creating&#xD;
      sustainable improvements in physical and psychosocial health in other populations with&#xD;
      cancer, though can present transportation and scheduling barriers. Additionally, medical&#xD;
      providers and participants undergoing treatment for cancer may be hesitant to engage in&#xD;
      group-based physical activity interventions during times of neutropenia given infection risk.&#xD;
&#xD;
      Dr. Rao's mentors have extensive preliminary data that guided her project's development. The&#xD;
      theoretical model for this study's intervention delivery is based on Dr. Rovniak's Social&#xD;
      Networks for Activity Promotion (SNAP) model, and targets optimizing the physical environment&#xD;
      where physical activity is received, as well as the importance of social network environments&#xD;
      and interactions. Dr. Schmitz has been at the forefront of the movement to incorporate&#xD;
      physical activity into the care of patients with cancer and cancer survivors. She has led&#xD;
      multiple trials, including a large randomized controlled trial to assess the safety of upper&#xD;
      body exercise among breast cancer survivors with and without lymphedema (Physical Activity&#xD;
      and Lymphedema Trial [PAL]). Dr. Sciamanna's work has evaluated the implementation of a group&#xD;
      strength training intervention in elderly patients, which has been found to be safe and&#xD;
      effective, as well socially beneficial to its participants. Dr. Williams is the founder and&#xD;
      president of Hip Hop for Public Health (HHPH) a non-profit organization which has&#xD;
      successfully utilized hip-hop music to deliver sustainable health messages pertaining to&#xD;
      nutrition and physical activity in youth.&#xD;
&#xD;
      The preliminary data as noted above set the foundation for this project, which builds on the&#xD;
      importance of social network environments and interactions in encouraging physical activity.&#xD;
      This is particularly true for adolescents as a whole, as social support has been found to be&#xD;
      an especially important factor in the promotion of physical activity. Specifically for AYAs&#xD;
      with cancer, physical activity has been cited as an area of preferred clinical program focus&#xD;
      for AYAs with cancer and those who have completed treatment. Thus, a group-based physical&#xD;
      activity intervention among AYAs with cancer could address an area of unmet need that&#xD;
      potentially improves the psychosocial health of this patient population. Delivery using a&#xD;
      virtual platform is culturally appropriate for AYAs with cancer, a unique patient population&#xD;
      that is technologically savvy, and interested in using social media platforms to create a&#xD;
      sense of belonging and community.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Active, not recruiting</overall_status>
  <start_date type="Actual">December 15, 2020</start_date>
  <completion_date type="Anticipated">December 2023</completion_date>
  <primary_completion_date type="Anticipated">December 2023</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>N/A</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <primary_purpose>Supportive Care</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Safety</measure>
    <time_frame>Weekly during 12 week study</time_frame>
    <description>Proportion of participants experiencing musculoskeletal (MSK) impairment, adverse effects requiring treatment alterations, and injury rate for MSK injuries (defined as symptoms lasting 1 week or longer and/or requiring attention of provider)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Feasibility</measure>
    <time_frame>At end of 12 week study</time_frame>
    <description>Physical activity intervention arm will be considered feasible if at least 50% of the participants complete 80% of the training sessions.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Acceptability</measure>
    <time_frame>At end of 12 week study</time_frame>
    <description>The physical activity intervention will be considered acceptable if more than 50% of the approached participants agree to receive at least the first session of the physical activity intervention.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Physical function assessments: Arm curl test of dominant arm (tests upper body strength)</measure>
    <time_frame>Baseline and at end of 12 week study</time_frame>
    <description>Arm curl test assessment will be performed on all participants using free weights of 5 lb and 8 lb (or household alternative object)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Physical function assessments: 30-second Chair Stand (tests leg strength and endurance)</measure>
    <time_frame>Baseline and at end of 12 week study</time_frame>
    <description>The 30-second Chair Stand will be performed on all participants</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Physical function assessments: Timed Up and Go (tests mobility)</measure>
    <time_frame>Baseline and at end of 12 week study</time_frame>
    <description>The Timed Up and Go test will be performed on all participants</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Physical function assessments: 4-Stage Balance (tests balance)</measure>
    <time_frame>Baseline and at end of 12 week study</time_frame>
    <description>The 4-Stage Balance will be performed on all participants</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Physical function assessments: Patient reported physical function</measure>
    <time_frame>Baseline and at end of 12 week study</time_frame>
    <description>Physical function: The Patient-Reported Outcomes Measurement Information System (PROMIS)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Psychosocial measurements: Distress</measure>
    <time_frame>Baseline and at end of 12 week study</time_frame>
    <description>Distress: The Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Psychological Stress Experiences Form will be used.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Psychosocial measurements: Social Isolation</measure>
    <time_frame>Baseline and at end of 12 week study</time_frame>
    <description>Social Isolation: The Patient-Reported Outcomes Measurement Information System (PROMIS) Item Bank Social Isolation Short Form 8a will be used.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Psychosocial measurements: Fatigue</measure>
    <time_frame>Baseline and at end of 12 week study</time_frame>
    <description>Fatigue: The Patient-Reported Outcomes Measurement Information System (PROMIS) Cancer Item Bank v1.0- Fatigue will be used.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Psychosocial measurements: Quality of Life</measure>
    <time_frame>Baseline and at end of 12 week study</time_frame>
    <description>Quality of Life: The Patient-Reported Outcomes Measurement Information System (PROMIS) PROMIS-29 Profile will be used.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient-reported symptoms</measure>
    <time_frame>All participants will be given this instrument once prior to study initiation, and once every 3 weeks during the study.</time_frame>
    <description>PRO-CTCAE will be used to collect and measure information of patient-PRO-CTCAE will be used to collect and measure information of patient-reported symptoms.</description>
  </secondary_outcome>
  <number_of_arms>1</number_of_arms>
  <enrollment type="Anticipated">10</enrollment>
  <condition>Adolescent</condition>
  <condition>Young Adult</condition>
  <condition>Cancer</condition>
  <condition>Physical Activity</condition>
  <condition>Psychological Distress</condition>
  <condition>Social Isolation</condition>
  <arm_group>
    <arm_group_label>Outpatient Physical Activity Program</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>The intervention will investigate a multi modal outpatient physical activity program incorporating both strength training utilizing resistance bands, as well as an aerobic activity based on hip-hop dancing.</description>
  </arm_group>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Physical Activity Intervention</intervention_name>
    <description>Participants will engage in a multimodal aerobic and strength training intervention.</description>
    <arm_group_label>Outpatient Physical Activity Program</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Participant age 15-21 years old at time of cancer diagnosis&#xD;
&#xD;
          -  Participant diagnosis of cancer who is currently undergoing active treatment for&#xD;
             cancer, or who is within 3 years of end of cancer treatment at the time of enrollment&#xD;
&#xD;
          -  Participant receiving oncologic care at Penn State Health Children's Hospital or Penn&#xD;
             State Cancer Institute&#xD;
&#xD;
          -  Participant fluency in written and spoken English for participants &gt;= 18 years old&#xD;
&#xD;
          -  Parent and participant fluency in written and spoken English for participants &lt; 18&#xD;
             years old&#xD;
&#xD;
          -  Primary attending oncologist approval&#xD;
&#xD;
          -  Participant must have access to a computer or smartphone&#xD;
&#xD;
          -  Performance status of ECOG &lt;= 2, and Lansky /Karnofsky scale &gt;= 50&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Cardiovascular or respiratory disease&#xD;
&#xD;
          -  Class II, III or IV heart failure as defined by the New York Heart Association&#xD;
             functional classification system&#xD;
&#xD;
          -  History of acute coronary syndromes (including myocardial infarction and unstable&#xD;
             angina), coronary angioplasty or stenting within the past 6 months prior to the start&#xD;
             of chemotherapy&#xD;
&#xD;
          -  Uncontrolled arrhythmias&#xD;
&#xD;
          -  Syncope&#xD;
&#xD;
          -  Acute myocarditis, pericarditis or endocarditis&#xD;
&#xD;
          -  Diagnosed with pulmonary embolism or pulmonary infarction within 3 months of&#xD;
             enrollment&#xD;
&#xD;
          -  Diagnosed with deep venous thrombosis within 3 months of enrollment&#xD;
&#xD;
          -  Any history of intracardiac thrombosis&#xD;
&#xD;
          -  Suspected dissecting aneurysm&#xD;
&#xD;
          -  Pulmonary edema&#xD;
&#xD;
          -  Respiratory failure&#xD;
&#xD;
          -  Acute non-cardiopulmonary disorder that may affect exercise performance or be&#xD;
             exacerbated by physical activity&#xD;
&#xD;
          -  Altered mental status or dementia&#xD;
&#xD;
          -  Mental impairment leading to inability to cooperate&#xD;
&#xD;
          -  Active bleeding&#xD;
&#xD;
          -  Absolute contraindication to exercise&#xD;
&#xD;
          -  Hemodynamic instability&#xD;
&#xD;
          -  Pregnant women&#xD;
&#xD;
          -  Non-English speaking&#xD;
&#xD;
          -  Recent initiation of physical activity program within last 3 months&#xD;
&#xD;
          -  Patients with relapsed cancer&#xD;
&#xD;
          -  Patients who have undergone allogeneic stem cell transplant&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>15 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Pooja Rao, MD MSCE</last_name>
    <role>Principal Investigator</role>
    <affiliation>Milton S. Hershey Medical Center</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Milton S. Hershey Medical Center</name>
      <address>
        <city>Hershey</city>
        <state>Pennsylvania</state>
        <zip>17033</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
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  </reference>
  <reference>
    <citation>Bourdon A, Grandy SA, Keats MR. Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis. Support Care Cancer. 2018 Jul;26(7):2113-2123. doi: 10.1007/s00520-018-4208-z. Epub 2018 Apr 18.</citation>
    <PMID>29671063</PMID>
  </reference>
  <reference>
    <citation>Reeve BB, McFatrich M, Pinheiro LC, Freyer DR, Basch EM, Baker JN, Withycombe JS, Sung L, Mack JW, Waldron MK, Mowbray C, Palma D, Hinds PS. Cognitive Interview-Based Validation of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events in Adolescents with Cancer. J Pain Symptom Manage. 2017 Apr;53(4):759-766. doi: 10.1016/j.jpainsymman.2016.11.006. Epub 2017 Jan 3.</citation>
    <PMID>28062347</PMID>
  </reference>
  <verification_date>January 2023</verification_date>
  <study_first_submitted>December 13, 2018</study_first_submitted>
  <study_first_submitted_qc>December 14, 2018</study_first_submitted_qc>
  <study_first_posted type="Actual">December 19, 2018</study_first_posted>
  <last_update_submitted>January 31, 2023</last_update_submitted>
  <last_update_submitted_qc>January 31, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">February 2, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Milton S. Hershey Medical Center</investigator_affiliation>
    <investigator_full_name>Pooja Rao</investigator_full_name>
    <investigator_title>Pooja Rao, M.D. , Assistant Professor</investigator_title>
  </responsible_party>
  <keyword>Adolescent/Young Adult</keyword>
  <keyword>Cancer</keyword>
  <keyword>Physical Activity</keyword>
  <keyword>Psychosocial Health</keyword>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03778658
org study id: STUDY00010118
nct id: NCT03778658
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Adolescents and young adults (AYAs) with cancer have many needs for supportive care that
      differ from younger and older patients.This includes age-appropriate psychological support
      for management of distress, as well as supports for the social isolation many AYAs
      experience. One intervention that may provide AYAs with cancer improved psychosocial support,
      as well as increased physical strength, is physical activity. This feasibility project aims
      to evaluate the safety, feasibility and acceptability of a physical activity training in AYAs
      with cancer delivered via a socially interactive videoconferencing platform.
Adolescents and young adults (AYAs) with cancer comprise a unique population within the
      larger cancer community. This is primarily due to distinct differences in disease biology
      compared to older and younger patients, as well as their unique psychosocial needs. AYAs with
      cancer historically have unmet needs relating to management of their mental health and
      treatment-related symptoms. One particular area of unmet need is distress management during
      cancer treatment, reported in nearly one third of AYAs with newly diagnosed cancer. Reasons
      for distress are multifactorial, including lack of medical information, worries about future
      life goals and fertility, and social isolation from peers and family. Proactively addressing
      and preventing this distress is critical for forestalling the high rates of depression,
      anxiety, and post-traumatic stress seen in AYAs. One promising but under explored
      intervention with the potential to mitigate distress is group-based physical activity.
      Multiple studies cite physical activity's benefits for patients with cancer, while oncology
      and sports medicine societies recommend including physical activity as part of comprehensive
      cancer care. Group physical activity intervention models have been successful in creating
      sustainable improvements in physical and psychosocial health in other populations with
      cancer, though can present transportation and scheduling barriers. Additionally, medical
      providers and participants undergoing treatment for cancer may be hesitant to engage in
      group-based physical activity interventions during times of neutropenia given infection risk.

      Dr. Rao's mentors have extensive preliminary data that guided her project's development. The
      theoretical model for this study's intervention delivery is based on Dr. Rovniak's Social
      Networks for Activity Promotion (SNAP) model, and targets optimizing the physical environment
      where physical activity is received, as well as the importance of social network environments
      and interactions. Dr. Schmitz has been at the forefront of the movement to incorporate
      physical activity into the care of patients with cancer and cancer survivors. She has led
      multiple trials, including a large randomized controlled trial to assess the safety of upper
      body exercise among breast cancer survivors with and without lymphedema (Physical Activity
      and Lymphedema Trial [PAL]). Dr. Sciamanna's work has evaluated the implementation of a group
      strength training intervention in elderly patients, which has been found to be safe and
      effective, as well socially beneficial to its participants. Dr. Williams is the founder and
      president of Hip Hop for Public Health (HHPH) a non-profit organization which has
      successfully utilized hip-hop music to deliver sustainable health messages pertaining to
      nutrition and physical activity in youth.

      The preliminary data as noted above set the foundation for this project, which builds on the
      importance of social network environments and interactions in encouraging physical activity.
      This is particularly true for adolescents as a whole, as social support has been found to be
      an especially important factor in the promotion of physical activity. Specifically for AYAs
      with cancer, physical activity has been cited as an area of preferred clinical program focus
      for AYAs with cancer and those who have completed treatment. Thus, a group-based physical
      activity intervention among AYAs with cancer could address an area of unmet need that
      potentially improves the psychosocial health of this patient population. Delivery using a
      virtual platform is culturally appropriate for AYAs with cancer, a unique patient population
      that is technologically savvy, and interested in using social media platforms to create a
      sense of belonging and community.
allocation: N/A
intervention model: Single Group Assignment
primary purpose: Supportive Care
masking: None (Open Label)
measure: Safety
time frame: Weekly during 12 week study
description: Proportion of participants experiencing musculoskeletal (MSK) impairment, adverse effects requiring treatment alterations, and injury rate for MSK injuries (defined as symptoms lasting 1 week or longer and/or requiring attention of provider)
measure: Feasibility
time frame: At end of 12 week study
description: Physical activity intervention arm will be considered feasible if at least 50% of the participants complete 80% of the training sessions.
measure: Acceptability
time frame: At end of 12 week study
description: The physical activity intervention will be considered acceptable if more than 50% of the approached participants agree to receive at least the first session of the physical activity intervention.
measure: Physical function assessments: Arm curl test of dominant arm (tests upper body strength)
time frame: Baseline and at end of 12 week study
description: Arm curl test assessment will be performed on all participants using free weights of 5 lb and 8 lb (or household alternative object)
measure: Physical function assessments: 30-second Chair Stand (tests leg strength and endurance)
time frame: Baseline and at end of 12 week study
description: The 30-second Chair Stand will be performed on all participants
measure: Physical function assessments: Timed Up and Go (tests mobility)
time frame: Baseline and at end of 12 week study
description: The Timed Up and Go test will be performed on all participants
measure: Physical function assessments: 4-Stage Balance (tests balance)
time frame: Baseline and at end of 12 week study
description: The 4-Stage Balance will be performed on all participants
measure: Physical function assessments: Patient reported physical function
time frame: Baseline and at end of 12 week study
description: Physical function: The Patient-Reported Outcomes Measurement Information System (PROMIS)
measure: Psychosocial measurements: Distress
time frame: Baseline and at end of 12 week study
description: Distress: The Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Psychological Stress Experiences Form will be used.
measure: Psychosocial measurements: Social Isolation
time frame: Baseline and at end of 12 week study
description: Social Isolation: The Patient-Reported Outcomes Measurement Information System (PROMIS) Item Bank Social Isolation Short Form 8a will be used.
measure: Psychosocial measurements: Fatigue
time frame: Baseline and at end of 12 week study
description: Fatigue: The Patient-Reported Outcomes Measurement Information System (PROMIS) Cancer Item Bank v1.0- Fatigue will be used.
measure: Psychosocial measurements: Quality of Life
time frame: Baseline and at end of 12 week study
description: Quality of Life: The Patient-Reported Outcomes Measurement Information System (PROMIS) PROMIS-29 Profile will be used.
measure: Patient-reported symptoms
time frame: All participants will be given this instrument once prior to study initiation, and once every 3 weeks during the study.
description: PRO-CTCAE will be used to collect and measure information of patient-PRO-CTCAE will be used to collect and measure information of patient-reported symptoms.
arm group label: Outpatient Physical Activity Program
arm group type: Experimental
description: The intervention will investigate a multi modal outpatient physical activity program incorporating both strength training utilizing resistance bands, as well as an aerobic activity based on hip-hop dancing.
intervention type: Behavioral
intervention name: Physical Activity Intervention
description: Participants will engage in a multimodal aerobic and strength training intervention.
arm group label: Outpatient Physical Activity Program
criteria: 
gender: All
minimum age: 15 Years
maximum age: N/A
healthy volunteers: No
last name: Pooja Rao, MD MSCE
role: Principal Investigator
affiliation: Milton S. Hershey Medical Center
facility: 
country: United States
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PMID: 29058129
citation: Bourdon A, Grandy SA, Keats MR. Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis. Support Care Cancer. 2018 Jul;26(7):2113-2123. doi: 10.1007/s00520-018-4208-z. Epub 2018 Apr 18.
PMID: 29671063
citation: Reeve BB, McFatrich M, Pinheiro LC, Freyer DR, Basch EM, Baker JN, Withycombe JS, Sung L, Mack JW, Waldron MK, Mowbray C, Palma D, Hinds PS. Cognitive Interview-Based Validation of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events in Adolescents with Cancer. J Pain Symptom Manage. 2017 Apr;53(4):759-766. doi: 10.1016/j.jpainsymman.2016.11.006. Epub 2017 Jan 3.
PMID: 28062347
responsible party type: Principal Investigator
investigator affiliation: Milton S. Hershey Medical Center
investigator full name: Pooja Rao
investigator title: Pooja Rao, M.D. , Assistant Professor
sharing ipd: No