<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03758599</url>
  </required_header>
  <id_info>
    <org_study_id>256912</org_study_id>
    <nct_id>NCT03758599</nct_id>
  </id_info>
  <brief_title>Exercise in Anxiety and Posttraumatic Stress Disorders</brief_title>
  <official_title>Exercise in Anxiety and Posttraumatic Stress Disorders - a Randomized Controlled Clinical Pilot Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Universitaet Innsbruck</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Medical University Innsbruck</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Universitaet Innsbruck</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Aim: Aerobic and resistance exercise showed anxiolytic effects in clinical populations.&#xD;
      Climbing could further enhance self-efficacy. Aim of the study is to examine whether climbing&#xD;
      exercise and aerobic exercise, compared to social contact control, reduces symptoms of&#xD;
      disease in out-patients with anxiety disorder (AD) and post-traumatic stress disorder (PTSD).&#xD;
      Further analyses are aiming to reveal differences between climbing - and aerobic exercise.&#xD;
&#xD;
      Design: Randomized controlled clinical trial Participants: Thirty out-patients diagnosed with&#xD;
      International Classification of Disease-Version 10 (ICD-10) (F40, F41, F43.1) for AD or PTSD.&#xD;
&#xD;
      Intervention: Out-patients will be assigned randomly to a climbing exercise group (a),&#xD;
      aerobic exercise group (Nordic walking) (b) or social contact control group (c).&#xD;
&#xD;
      Measurements: Primary outcome is symptom severity in AD or Post Traumatic Stress Disorders.&#xD;
      Further secondary outcomes are evaluated by psychological questionnaires assessing&#xD;
      depression, worry symptoms, quality of life, self-efficacy and affective responses.&#xD;
      Metabolites of neurotransmitters, immune-activation markers and anthropometric data will be&#xD;
      additionally provided as secondary physiological outcomes.&#xD;
&#xD;
      Duration: Intervention duration is four weeks with 2 x 75 min for every group (climbing&#xD;
      exercise, aerobic exercise, social contact control). Measurement points are set at the&#xD;
      beginning (t1), at the end of the intervention (t2) and 3 (t3) and 6 (t4) months follow-up.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The proposed research project is designed as a randomized controlled clinical trial with&#xD;
      three arms. The efficacy of a climbing exercise program, an aerobic exercise program and a&#xD;
      social contact control group on primary and secondary study outcome will be investigated (see&#xD;
      Figure 1). Patients will be first screened by the outpatient-unit of the Department of&#xD;
      Psychosomatics at the Medical University of Innsbruck or remitted through the treating staff&#xD;
      network community. When assessed as eligible for the study, a group of up to ten out-patients&#xD;
      will be randomly selected and invited to an informative meeting. Patients receive study&#xD;
      information and time tables for their group attendances. The intervention will start within&#xD;
      the following week and will end four weeks after beginning. Follow-up assessments will take&#xD;
      place three and six months after intervention.&#xD;
&#xD;
      In addition to the AD/PTSD symptom screening, secondary study outcomes will be assessed:&#xD;
&#xD;
        -  at study inclusion (t1)&#xD;
&#xD;
        -  at the end of the intervention (t2)&#xD;
&#xD;
        -  three months after the intervention (t3)&#xD;
&#xD;
        -  six months after the intervention (t4)&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">October 1, 2017</start_date>
  <completion_date type="Actual">December 1, 2020</completion_date>
  <primary_completion_date type="Actual">September 1, 2020</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>Randomized controlled clinical trial with three arms for the comparison of the efficacy of a climbing exercise program, an aerobic exercise program and a social contact control group on symptoms of AD/PTSD, worry symptoms, quality of life, physical activity, health-related resources and affective responses in patients with AD or PTSD.</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Participant)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Change from Baseline (t1) Symptoms of Anxiety at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)</measure>
    <time_frame>1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours</time_frame>
    <description>Beck Anxiety Inventory (BAI; Beck &amp; Steer, 1990) The BAI ranges from 0 and 63 points with lower points indicating less symptoms of anxiety</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Change from Baseline (t1) Symptoms of Posttraumatic Stress Disorder at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)</measure>
    <time_frame>1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours</time_frame>
    <description>Post Traumatic Stress Disorder Checklist Civil Version (PCL-5; Weathers et al., 2013) The PCL-5 ranges from 0 and 80 points with lower points indicating less symptoms of PTSD The PCL-5 ranges from 0 and 80 points with lower points indicating less symptoms of Posttraumatic Stress Disorder</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Change from Baseline (t1) Depression at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)</measure>
    <time_frame>1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours</time_frame>
    <description>Beck Depression Inventory (BDI-II; Beck et al., 1996) The BDI-II ranges from 0 and 63 points with lower points indicating less symptoms of depression.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change from Baseline (t1) Worry Symptoms at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)</measure>
    <time_frame>1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours</time_frame>
    <description>Penn-State Worry Questionnaire (PSWQ; Meyer et al., 1990) The PSWQ ranges from 16 and 80 points with lower points indicating less worries.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change from Baseline (t1) Quality of Life (WHO) at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)</measure>
    <time_frame>1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours</time_frame>
    <description>Quality of life (WHOQOL-BREF; WHOQOL Group, 1998) The WHOQOL-BREF ranges from 5 and 130 points with lower points indicating less quality of life.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change from Baseline (t1) Self Efficacy at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)</measure>
    <time_frame>1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours</time_frame>
    <description>General Self-Efficacy Scale (GSE; Schwarzer &amp; Jerusalem, 1995) The GSE ranges from 4 and 40 points with lower points indicating less resources in self efficacy.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Affective Responses_a</measure>
    <time_frame>1 minute before each intervention, after 38 minutes, after 75 minutes</time_frame>
    <description>Feeling Scale (FS; Hardy &amp; Rejeski, 1989) The FS ranges from +5 to -5 points with lower points indicating low affective valence.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Affective Responses_b</measure>
    <time_frame>1 minute before each intervention, after 38 minutes, after 75 minutes</time_frame>
    <description>Felt Arousal Scale (FAS; Svebak &amp; Murgatroyd, 1985) The FAS ranges from 1 to 6 points with lower points indicating low level of arousal.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Affective Responses_c</measure>
    <time_frame>1 minute before each intervention, after 75 minutes</time_frame>
    <description>The Positive and Negative Affect Scale (PANAS; Watson, Clark, &amp; Tellegen, 1988) The PANAS measures two subscales, positive affect (points ranging from 10 to 50) and negative affect (points ranging from 10 to 50) Lower points on positive subscale indicates low level of positive affect, low points on negative affect subscale indicates low level of negative affect.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Affective Responses_d</measure>
    <time_frame>38 minutes after beginning of intervention</time_frame>
    <description>Rating of Perceived Exertion (RPE; Borg, 1998)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change from Baseline (t1) Analyses of neurotransmitter metabolites at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)</measure>
    <time_frame>1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours</time_frame>
    <description>tryptophan-kynurenine and the phenylalanine-tyrosine pathways</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change from Baseline (t1) Analyses of immune-activation markers at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)</measure>
    <time_frame>1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours</time_frame>
    <description>neopterin and pro-inflammatory cytokines</description>
  </secondary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Actual">60</enrollment>
  <condition>Anxiety</condition>
  <arm_group>
    <arm_group_label>Climbing Exercise Group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>At the beginning of each session, a standardized body-centered, mind-setting warmup of ten minutes will take place. The general warm-up will be followed by climbing specific warm-up, which will consist of bouldering (20-30 minutes). Afterwards the rope climbing session will start. Climbing sessions also contain several sport-specific skill-development training sessions to familiarize the participants with gear and rope management, to acquire footwork and route finding, and to locate good belay spots and resting positions while climbing. At the end of the climbing session a short cool-down of five minutes will be executed.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Aerobic Exercise Group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>As the climbing exercise group, the aerobic exercise group will start with a ten minutes body-centered, mind-setting warm-up, followed by 60 minutes of Nordic walking and five minutes cool down. A physiotherapist or sport scientist will instruct and guide the group. Nordic walking will be performed at a moderate pace at varying paths.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Social Contact Control Group</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Patients allocated to the social contact control group will receive the same amount of social interaction as the exercise groups. A physiotherapist or sport scientist will be present while participants watch movies with relevant content to disease followed by interactive group discussions. This group is required to control for the impact of social contact/support on AD/PTSD and secondary outcomes.</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Climbing</intervention_name>
    <description>All interventions are identical in their duration. To fulfill the WHO guidelines of health enhancing activity (minimum 150 minutes of moderate exercise per week), two 75 minutes exercise sessions per week will take place. After meeting the inclusion criteria and after allocation to one of the three groups, patients will receive their timetable with the exercise or group session dates.</description>
    <arm_group_label>Climbing Exercise Group</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Nordic Walking</intervention_name>
    <description>All interventions are identical in their duration. To fulfill the WHO guidelines of health enhancing activity (minimum 150 minutes of moderate exercise per week), two 75 minutes exercise sessions per week will take place. After meeting the inclusion criteria and after allocation to one of the three groups, patients will receive their timetable with the exercise or group session dates.</description>
    <arm_group_label>Aerobic Exercise Group</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Social Contact</intervention_name>
    <description>All interventions are identical in their duration. To fulfill the WHO guidelines of health enhancing activity (minimum 150 minutes of moderate exercise per week), two 75 minutes exercise sessions per week will take place. After meeting the inclusion criteria and after allocation to one of the three groups, patients will receive their timetable with the exercise or group session dates.</description>
    <arm_group_label>Social Contact Control Group</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  ICD-10 diagnosis of Anxiety Disorder or Post Traumatic Stress Disorder: F40, F41,&#xD;
             F43.1;&#xD;
&#xD;
          -  age range: 18-65&#xD;
&#xD;
          -  written informed consent&#xD;
&#xD;
          -  stable medication (if needed) for at least 3 weeks&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  acute psychosis or suicidal behaviour&#xD;
&#xD;
          -  medical contraindication to physical activity (assessed by a clinician)&#xD;
&#xD;
          -  cognitive deficits&#xD;
&#xD;
          -  problems with German language&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>65 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Barbara Sperner-Unterweger, Prof. MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>University Hospital of Psychiatry II, Department of Psychiatry, Psychotherapy and Psychosomatics, Innsbruck Medical University</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>University of Innsbruck</name>
      <address>
        <city>Innsbruck</city>
        <state>Tyrol</state>
        <zip>6020</zip>
        <country>Austria</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Austria</country>
  </location_countries>
  <verification_date>September 2021</verification_date>
  <study_first_submitted>October 11, 2018</study_first_submitted>
  <study_first_submitted_qc>November 27, 2018</study_first_submitted_qc>
  <study_first_posted type="Actual">November 29, 2018</study_first_posted>
  <last_update_submitted>September 29, 2021</last_update_submitted>
  <last_update_submitted_qc>September 29, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">October 1, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Anxiety Disorder</keyword>
  <keyword>Posttraumatic Stress Disorder</keyword>
  <keyword>Sports intervention</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Anxiety Disorders</mesh_term>
    <mesh_term>Stress Disorders, Traumatic</mesh_term>
    <mesh_term>Stress Disorders, Post-Traumatic</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03758599
org study id: 256912
nct id: NCT03758599
lead sponsor: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Aim: Aerobic and resistance exercise showed anxiolytic effects in clinical populations.
      Climbing could further enhance self-efficacy. Aim of the study is to examine whether climbing
      exercise and aerobic exercise, compared to social contact control, reduces symptoms of
      disease in out-patients with anxiety disorder (AD) and post-traumatic stress disorder (PTSD).
      Further analyses are aiming to reveal differences between climbing - and aerobic exercise.

      Design: Randomized controlled clinical trial Participants: Thirty out-patients diagnosed with
      International Classification of Disease-Version 10 (ICD-10) (F40, F41, F43.1) for AD or PTSD.

      Intervention: Out-patients will be assigned randomly to a climbing exercise group (a),
      aerobic exercise group (Nordic walking) (b) or social contact control group (c).

      Measurements: Primary outcome is symptom severity in AD or Post Traumatic Stress Disorders.
      Further secondary outcomes are evaluated by psychological questionnaires assessing
      depression, worry symptoms, quality of life, self-efficacy and affective responses.
      Metabolites of neurotransmitters, immune-activation markers and anthropometric data will be
      additionally provided as secondary physiological outcomes.

      Duration: Intervention duration is four weeks with 2 x 75 min for every group (climbing
      exercise, aerobic exercise, social contact control). Measurement points are set at the
      beginning (t1), at the end of the intervention (t2) and 3 (t3) and 6 (t4) months follow-up.
The proposed research project is designed as a randomized controlled clinical trial with
      three arms. The efficacy of a climbing exercise program, an aerobic exercise program and a
      social contact control group on primary and secondary study outcome will be investigated (see
      Figure 1). Patients will be first screened by the outpatient-unit of the Department of
      Psychosomatics at the Medical University of Innsbruck or remitted through the treating staff
      network community. When assessed as eligible for the study, a group of up to ten out-patients
      will be randomly selected and invited to an informative meeting. Patients receive study
      information and time tables for their group attendances. The intervention will start within
      the following week and will end four weeks after beginning. Follow-up assessments will take
      place three and six months after intervention.

      In addition to the AD/PTSD symptom screening, secondary study outcomes will be assessed:

        -  at study inclusion (t1)

        -  at the end of the intervention (t2)

        -  three months after the intervention (t3)

        -  six months after the intervention (t4)
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: Randomized controlled clinical trial with three arms for the comparison of the efficacy of a climbing exercise program, an aerobic exercise program and a social contact control group on symptoms of AD/PTSD, worry symptoms, quality of life, physical activity, health-related resources and affective responses in patients with AD or PTSD.
primary purpose: Treatment
masking: Single (Participant)
measure: Change from Baseline (t1) Symptoms of Anxiety at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)
time frame: 1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours
description: Beck Anxiety Inventory (BAI; Beck & Steer, 1990) The BAI ranges from 0 and 63 points with lower points indicating less symptoms of anxiety
measure: Change from Baseline (t1) Symptoms of Posttraumatic Stress Disorder at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)
time frame: 1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours
description: Post Traumatic Stress Disorder Checklist Civil Version (PCL-5; Weathers et al., 2013) The PCL-5 ranges from 0 and 80 points with lower points indicating less symptoms of PTSD The PCL-5 ranges from 0 and 80 points with lower points indicating less symptoms of Posttraumatic Stress Disorder
measure: Change from Baseline (t1) Depression at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)
time frame: 1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours
description: Beck Depression Inventory (BDI-II; Beck et al., 1996) The BDI-II ranges from 0 and 63 points with lower points indicating less symptoms of depression.
measure: Change from Baseline (t1) Worry Symptoms at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)
time frame: 1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours
description: Penn-State Worry Questionnaire (PSWQ; Meyer et al., 1990) The PSWQ ranges from 16 and 80 points with lower points indicating less worries.
measure: Change from Baseline (t1) Quality of Life (WHO) at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)
time frame: 1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours
description: Quality of life (WHOQOL-BREF; WHOQOL Group, 1998) The WHOQOL-BREF ranges from 5 and 130 points with lower points indicating less quality of life.
measure: Change from Baseline (t1) Self Efficacy at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)
time frame: 1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours
description: General Self-Efficacy Scale (GSE; Schwarzer & Jerusalem, 1995) The GSE ranges from 4 and 40 points with lower points indicating less resources in self efficacy.
measure: Affective Responses_a
time frame: 1 minute before each intervention, after 38 minutes, after 75 minutes
description: Feeling Scale (FS; Hardy & Rejeski, 1989) The FS ranges from +5 to -5 points with lower points indicating low affective valence.
measure: Affective Responses_b
time frame: 1 minute before each intervention, after 38 minutes, after 75 minutes
description: Felt Arousal Scale (FAS; Svebak & Murgatroyd, 1985) The FAS ranges from 1 to 6 points with lower points indicating low level of arousal.
measure: Affective Responses_c
time frame: 1 minute before each intervention, after 75 minutes
description: The Positive and Negative Affect Scale (PANAS; Watson, Clark, & Tellegen, 1988) The PANAS measures two subscales, positive affect (points ranging from 10 to 50) and negative affect (points ranging from 10 to 50) Lower points on positive subscale indicates low level of positive affect, low points on negative affect subscale indicates low level of negative affect.
measure: Affective Responses_d
time frame: 38 minutes after beginning of intervention
description: Rating of Perceived Exertion (RPE; Borg, 1998)
measure: Change from Baseline (t1) Analyses of neurotransmitter metabolites at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)
time frame: 1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours
description: tryptophan-kynurenine and the phenylalanine-tyrosine pathways
measure: Change from Baseline (t1) Analyses of immune-activation markers at four weeks (t2), three months after intervention (t3) and six months after intervention (t4)
time frame: 1 hour before intervention, after 672 hours, after 2328 hours, after 4488 hours
description: neopterin and pro-inflammatory cytokines
arm group label: Climbing Exercise Group
arm group type: Experimental
description: At the beginning of each session, a standardized body-centered, mind-setting warmup of ten minutes will take place. The general warm-up will be followed by climbing specific warm-up, which will consist of bouldering (20-30 minutes). Afterwards the rope climbing session will start. Climbing sessions also contain several sport-specific skill-development training sessions to familiarize the participants with gear and rope management, to acquire footwork and route finding, and to locate good belay spots and resting positions while climbing. At the end of the climbing session a short cool-down of five minutes will be executed.
arm group label: Aerobic Exercise Group
arm group type: Experimental
description: As the climbing exercise group, the aerobic exercise group will start with a ten minutes body-centered, mind-setting warm-up, followed by 60 minutes of Nordic walking and five minutes cool down. A physiotherapist or sport scientist will instruct and guide the group. Nordic walking will be performed at a moderate pace at varying paths.
arm group label: Social Contact Control Group
arm group type: Active Comparator
description: Patients allocated to the social contact control group will receive the same amount of social interaction as the exercise groups. A physiotherapist or sport scientist will be present while participants watch movies with relevant content to disease followed by interactive group discussions. This group is required to control for the impact of social contact/support on AD/PTSD and secondary outcomes.
intervention type: Procedure
intervention name: Climbing
description: All interventions are identical in their duration. To fulfill the WHO guidelines of health enhancing activity (minimum 150 minutes of moderate exercise per week), two 75 minutes exercise sessions per week will take place. After meeting the inclusion criteria and after allocation to one of the three groups, patients will receive their timetable with the exercise or group session dates.
arm group label: Climbing Exercise Group
intervention type: Procedure
intervention name: Nordic Walking
description: All interventions are identical in their duration. To fulfill the WHO guidelines of health enhancing activity (minimum 150 minutes of moderate exercise per week), two 75 minutes exercise sessions per week will take place. After meeting the inclusion criteria and after allocation to one of the three groups, patients will receive their timetable with the exercise or group session dates.
arm group label: Aerobic Exercise Group
intervention type: Procedure
intervention name: Social Contact
description: All interventions are identical in their duration. To fulfill the WHO guidelines of health enhancing activity (minimum 150 minutes of moderate exercise per week), two 75 minutes exercise sessions per week will take place. After meeting the inclusion criteria and after allocation to one of the three groups, patients will receive their timetable with the exercise or group session dates.
arm group label: Social Contact Control Group
criteria: 
gender: All
minimum age: 18 Years
maximum age: 65 Years
healthy volunteers: No
last name: Barbara Sperner-Unterweger, Prof. MD
role: Principal Investigator
affiliation: University Hospital of Psychiatry II, Department of Psychiatry, Psychotherapy and Psychosomatics, Innsbruck Medical University
facility: 
country: Austria
responsible party type: Sponsor
mesh term: Anxiety Disorders
mesh term: Stress Disorders, Traumatic
mesh term: Stress Disorders, Post-Traumatic
sharing ipd: No