<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03814577</url>
  </required_header>
  <id_info>
    <org_study_id>sedatakbas6</org_study_id>
    <nct_id>NCT03814577</nct_id>
  </id_info>
  <brief_title>A Comparison of the Effects of Desflurane and TIVA on Antioxidant System in Morbidly Obese Patients</brief_title>
  <acronym>OxSys</acronym>
  <official_title>A Comparison of the Effects of Desflurane and Total Intravenous Anesthesia (TIVA) on Antioxidant System in Morbidly Obese Patients Undergoing Bariatric Surgery: A Randomized Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Inonu University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Inonu University</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      With the development of technology, the safety of anesthesia devices and the progression of&#xD;
      monitoring techniques affect the anesthetic management. There are some disadvantages such as&#xD;
      high cost of inhalation anesthetics and long postoperative recovery time. The effects of&#xD;
      total intravenous anesthesia (TIVA), which has been used for many years and whose positive&#xD;
      aspects are well known, on antioxidant system in high risk patients such as morbid obese&#xD;
      should be investigated. The aim of this study was to compare the effects of desflurane&#xD;
      anesthesia and total intravenous anesthesia (TIVA) on the antioxidant system in morbidly&#xD;
      obese patients undergoing bariatric surgery.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Obesity is a chronic disease that negatively affects the quality and duration of life. It is&#xD;
      one of the most important health problem in the world and very common in Turkey. Morbid&#xD;
      obesity operations have started to be performed frequently in our country with the effective&#xD;
      results obtained with the continuation of weight loss after being widely applied in Europe&#xD;
      and the United States. In our country, with the increase of obesity, laparoscopic bariatric&#xD;
      is preferred especially with low complication rates.&#xD;
&#xD;
      Inhalation anesthesia is still a major source of chemical hazard in the hospital environment&#xD;
      due to the widespread use in operating rooms. Factors affecting the presence of anesthetic&#xD;
      gases in the environment; device leakage, ventilation, fresh gas flow and operation of the&#xD;
      air wasting system. Long-term exposure to anesthetic gases is known to adversely affect the&#xD;
      health of the workers in the operating room.&#xD;
&#xD;
      It has been shown that many anesthetic agents produce free radicals and alter serum&#xD;
      antioxidant levels in patients. Antioxidant enzymes clean free radicals. Free radicals&#xD;
      induced by various diseases can trigger oxidative stress and result in increased oxidative&#xD;
      products. It was reported that particularly desflurane induced oxidative stress and increased&#xD;
      oxidative products. At the same time, it was reported that desflurane triggered local and&#xD;
      systemic oxidative stress in the experimental studies, but propofol had antioxidant&#xD;
      properties.&#xD;
&#xD;
      With the development of technology, the safety of anesthesia devices and the progression of&#xD;
      monitoring techniques affect the anesthetic management. There are some disadvantages such as&#xD;
      high cost of inhalation anesthetics and long postoperative recovery time. The effects of&#xD;
      total intravenous anesthesia (TIVA), which has been used for many years and whose positive&#xD;
      aspects are well known, on antioxidant system in high risk patients such as morbid obese&#xD;
      should be investigated. The aim of this study was to compare the effects of desflurane&#xD;
      anesthesia and total intravenous anesthesia (TIVA) on the antioxidant system in morbidly&#xD;
      obese patients undergoing bariatric surgery.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">January 24, 2019</start_date>
  <completion_date type="Actual">July 21, 2019</completion_date>
  <primary_completion_date type="Actual">June 21, 2019</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>Prospective Randomized Clinical Study</intervention_model_description>
    <primary_purpose>Screening</primary_purpose>
    <masking>None (Open Label)</masking>
    <masking_description>Single (Investigator)</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Total Antioxidant Status</measure>
    <time_frame>Total Antioxidant Status 15 minutes before the anesthesia (preoperative period)</time_frame>
    <description>Total Antioxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Total Antioxidant Status</measure>
    <time_frame>Total Antioxidant Status during the anesthesia (perioperative period, 60 minutes after the anesthesia induction)</time_frame>
    <description>Total Antioxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Total Antioxidant Status</measure>
    <time_frame>Total Antioxidant Status after the anesthesia (postoperative period, 120 minutes after the surgery)</time_frame>
    <description>Total Antioxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Total Oxidant Status</measure>
    <time_frame>120 minutes</time_frame>
    <description>Total Oxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Total Oxidant Status</measure>
    <time_frame>Total Oxidant Status during the anesthesia (perioperative period, 60 minutes after the anesthesia induction)</time_frame>
    <description>Total Oxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Total Oxidant Status</measure>
    <time_frame>Total Oxidant Status after the anesthesia (postoperative period, 120 minutes after the surgery)</time_frame>
    <description>Total Oxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Heart rate</measure>
    <time_frame>From beginning of anesthesia (15 minutes before anesthesia) to end of anesthesia (15 minutes after anesthesia) up to nearly 5 hours]</time_frame>
    <description>Heart rate (beat/min)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Mean Arterial Pressure</measure>
    <time_frame>From beginning of anesthesia (15 minutes before anesthesia) to end of anesthesia (15 minutes after anesthesia) up to nearly 5 hours</time_frame>
    <description>Mean Arterial Pressure (mmHg)</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">70</enrollment>
  <condition>Oxidative Stress</condition>
  <condition>Morbid Obesity</condition>
  <arm_group>
    <arm_group_label>Desflurane</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Anesthesia will be maintained with Desflurane inhalation with a flow of 2 L/min in 0.5 O2 oxygen air mixture.Total Intravenous Anesthesia will not be used in this group. While target desflurane minimum alveolar concentration (MAC) will be 1-1.5 and Bispectral Index values will be between 40-60, the flow rate will be adjusted to 2 L/min. Total Antioxidant Status and Total Oxidant Status will be then measured. Invasive arterial monitorization will be performed to right radial artery under local anesthesia to follow up hemodynamic changes and take the blood samples.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Total Intravenous Anesthesia</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Total Intravenous Anesthesia: Anesthesia will be maintained with inhalation with a flow of 2 L/min in 0.5 O2 oxygen air mixture. Desflurane will not be used in this group. Total Intravenous Anesthesia (propofol and remifentanyl infusion) will be performed to the patients while target Bispectral Index values were between 40-60. Also the flow rate will be adjusted to 2 L/min. Total Antioxidant Status and Total Oxidant Status will be then measured. Invasive arterial monitorization will be performed to right radial artery under local anesthesia to follow up hemodynamic changes and take the blood samples.</description>
  </arm_group>
  <intervention>
    <intervention_type>Diagnostic Test</intervention_type>
    <intervention_name>Total Antioxidant Status</intervention_name>
    <description>Total Antioxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.</description>
    <arm_group_label>Desflurane</arm_group_label>
    <arm_group_label>Total Intravenous Anesthesia</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Diagnostic Test</intervention_type>
    <intervention_name>Total Oxidant Status</intervention_name>
    <description>Total Oxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.</description>
    <arm_group_label>Desflurane</arm_group_label>
    <arm_group_label>Total Intravenous Anesthesia</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Bispectral Index</intervention_name>
    <description>Bispectral Index is a method for depth of anesthesia and assessment of sedation. The values of bispectral index decreases with the deepening of anesthesia. The values of 40-60 characterize the appropriate depth of anesthesia.</description>
    <arm_group_label>Desflurane</arm_group_label>
    <arm_group_label>Total Intravenous Anesthesia</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Invasive arterial monitorization</intervention_name>
    <description>Invasive arterial monitorization will be performed to right radial artery under local anesthesia to follow up hemodynamic changes and take the blood samples.</description>
    <arm_group_label>Desflurane</arm_group_label>
    <arm_group_label>Total Intravenous Anesthesia</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  American Society of Anesthesiology score I-III,&#xD;
&#xD;
          -  18-65 years,&#xD;
&#xD;
          -  BMI&gt; 40&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  American Society of Anesthesiology IV,&#xD;
&#xD;
          -  Under 18 years,&#xD;
&#xD;
          -  Over 65 years,&#xD;
&#xD;
          -  Obstetric patients,&#xD;
&#xD;
          -  Uncontrolled diabetes mellitus, cardiovascular and pulmonary disease,&#xD;
&#xD;
          -  Cerebrovascular disease,&#xD;
&#xD;
          -  Patients who refused informed consent forms&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>65 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Sedat Akbas, Asst. Prof.</last_name>
    <role>Principal Investigator</role>
    <affiliation>Inonu University Medical Faculty</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Sedat Akbas</name>
      <address>
        <city>Malatya</city>
        <state>Türkiye-Türkçe</state>
        <zip>44090</zip>
        <country>Turkey</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Turkey</country>
  </location_countries>
  <reference>
    <citation>Han C, Ding W, Jiang W, Chen YU, Hang D, Gu D, Jiang G, Tan Y, Ge Z, Ma T. A comparison of the effects of midazolam, propofol and dexmedetomidine on the antioxidant system: A randomized trial. Exp Ther Med. 2015 Jun;9(6):2293-2298. doi: 10.3892/etm.2015.2410. Epub 2015 Apr 7.</citation>
    <PMID>26136976</PMID>
  </reference>
  <verification_date>August 2019</verification_date>
  <study_first_submitted>January 7, 2019</study_first_submitted>
  <study_first_submitted_qc>January 18, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">January 24, 2019</study_first_posted>
  <last_update_submitted>August 16, 2019</last_update_submitted>
  <last_update_submitted_qc>August 16, 2019</last_update_submitted_qc>
  <last_update_posted type="Actual">August 19, 2019</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Inonu University</investigator_affiliation>
    <investigator_full_name>Sedat AKBAS</investigator_full_name>
    <investigator_title>Asst. Prof. Dr. Sedat Akbas</investigator_title>
  </responsible_party>
  <keyword>General anesthesia</keyword>
  <keyword>Inhalation anesthetics</keyword>
  <keyword>Total Intravenous anesthesia</keyword>
  <keyword>Oxidative Stress</keyword>
  <keyword>Morbid Obesity</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Obesity, Morbid</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Antioxidants</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <provided_document_section>
    <provided_document>
      <document_type>Study Protocol and Statistical Analysis Plan</document_type>
      <document_has_protocol>Yes</document_has_protocol>
      <document_has_icf>No</document_has_icf>
      <document_has_sap>Yes</document_has_sap>
      <document_date>March 7, 2018</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/77/NCT03814577/Prot_SAP_000.pdf</document_url>
    </provided_document>
  </provided_document_section>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03814577
org study id: sedatakbas6
nct id: NCT03814577
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
With the development of technology, the safety of anesthesia devices and the progression of
      monitoring techniques affect the anesthetic management. There are some disadvantages such as
      high cost of inhalation anesthetics and long postoperative recovery time. The effects of
      total intravenous anesthesia (TIVA), which has been used for many years and whose positive
      aspects are well known, on antioxidant system in high risk patients such as morbid obese
      should be investigated. The aim of this study was to compare the effects of desflurane
      anesthesia and total intravenous anesthesia (TIVA) on the antioxidant system in morbidly
      obese patients undergoing bariatric surgery.
Obesity is a chronic disease that negatively affects the quality and duration of life. It is
      one of the most important health problem in the world and very common in Turkey. Morbid
      obesity operations have started to be performed frequently in our country with the effective
      results obtained with the continuation of weight loss after being widely applied in Europe
      and the United States. In our country, with the increase of obesity, laparoscopic bariatric
      is preferred especially with low complication rates.

      Inhalation anesthesia is still a major source of chemical hazard in the hospital environment
      due to the widespread use in operating rooms. Factors affecting the presence of anesthetic
      gases in the environment; device leakage, ventilation, fresh gas flow and operation of the
      air wasting system. Long-term exposure to anesthetic gases is known to adversely affect the
      health of the workers in the operating room.

      It has been shown that many anesthetic agents produce free radicals and alter serum
      antioxidant levels in patients. Antioxidant enzymes clean free radicals. Free radicals
      induced by various diseases can trigger oxidative stress and result in increased oxidative
      products. It was reported that particularly desflurane induced oxidative stress and increased
      oxidative products. At the same time, it was reported that desflurane triggered local and
      systemic oxidative stress in the experimental studies, but propofol had antioxidant
      properties.

      With the development of technology, the safety of anesthesia devices and the progression of
      monitoring techniques affect the anesthetic management. There are some disadvantages such as
      high cost of inhalation anesthetics and long postoperative recovery time. The effects of
      total intravenous anesthesia (TIVA), which has been used for many years and whose positive
      aspects are well known, on antioxidant system in high risk patients such as morbid obese
      should be investigated. The aim of this study was to compare the effects of desflurane
      anesthesia and total intravenous anesthesia (TIVA) on the antioxidant system in morbidly
      obese patients undergoing bariatric surgery.
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: Prospective Randomized Clinical Study
primary purpose: Screening
masking: None (Open Label)
masking description: Single (Investigator)
measure: Total Antioxidant Status
time frame: Total Antioxidant Status 15 minutes before the anesthesia (preoperative period)
description: Total Antioxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.
measure: Total Antioxidant Status
time frame: Total Antioxidant Status during the anesthesia (perioperative period, 60 minutes after the anesthesia induction)
description: Total Antioxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.
measure: Total Antioxidant Status
time frame: Total Antioxidant Status after the anesthesia (postoperative period, 120 minutes after the surgery)
description: Total Antioxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.
measure: Total Oxidant Status
time frame: 120 minutes
description: Total Oxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.
measure: Total Oxidant Status
time frame: Total Oxidant Status during the anesthesia (perioperative period, 60 minutes after the anesthesia induction)
description: Total Oxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.
measure: Total Oxidant Status
time frame: Total Oxidant Status after the anesthesia (postoperative period, 120 minutes after the surgery)
description: Total Oxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.
measure: Heart rate
time frame: From beginning of anesthesia (15 minutes before anesthesia) to end of anesthesia (15 minutes after anesthesia) up to nearly 5 hours]
description: Heart rate (beat/min)
measure: Mean Arterial Pressure
time frame: From beginning of anesthesia (15 minutes before anesthesia) to end of anesthesia (15 minutes after anesthesia) up to nearly 5 hours
description: Mean Arterial Pressure (mmHg)
arm group label: Desflurane
arm group type: Active Comparator
description: Anesthesia will be maintained with Desflurane inhalation with a flow of 2 L/min in 0.5 O2 oxygen air mixture.Total Intravenous Anesthesia will not be used in this group. While target desflurane minimum alveolar concentration (MAC) will be 1-1.5 and Bispectral Index values will be between 40-60, the flow rate will be adjusted to 2 L/min. Total Antioxidant Status and Total Oxidant Status will be then measured. Invasive arterial monitorization will be performed to right radial artery under local anesthesia to follow up hemodynamic changes and take the blood samples.
arm group label: Total Intravenous Anesthesia
arm group type: Experimental
description: Total Intravenous Anesthesia: Anesthesia will be maintained with inhalation with a flow of 2 L/min in 0.5 O2 oxygen air mixture. Desflurane will not be used in this group. Total Intravenous Anesthesia (propofol and remifentanyl infusion) will be performed to the patients while target Bispectral Index values were between 40-60. Also the flow rate will be adjusted to 2 L/min. Total Antioxidant Status and Total Oxidant Status will be then measured. Invasive arterial monitorization will be performed to right radial artery under local anesthesia to follow up hemodynamic changes and take the blood samples.
intervention type: Diagnostic Test
intervention name: Total Antioxidant Status
description: Total Antioxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.
arm group label: Desflurane
arm group label: Total Intravenous Anesthesia
intervention type: Diagnostic Test
intervention name: Total Oxidant Status
description: Total Oxidant Status values will be determined using a novel automated measurement method. The colour intensity, which can be measured spectrophotometrically, is related to the total amount of oxidant molecules present in the sample. The assay is calibrated with hydrogen peroxide) and the results are expressed in terms of micromolar hydrogen peroxide equivalent per litre.
arm group label: Desflurane
arm group label: Total Intravenous Anesthesia
intervention type: Device
intervention name: Bispectral Index
description: Bispectral Index is a method for depth of anesthesia and assessment of sedation. The values of bispectral index decreases with the deepening of anesthesia. The values of 40-60 characterize the appropriate depth of anesthesia.
arm group label: Desflurane
arm group label: Total Intravenous Anesthesia
intervention type: Other
intervention name: Invasive arterial monitorization
description: Invasive arterial monitorization will be performed to right radial artery under local anesthesia to follow up hemodynamic changes and take the blood samples.
arm group label: Desflurane
arm group label: Total Intravenous Anesthesia
criteria: 
gender: All
minimum age: 18 Years
maximum age: 65 Years
healthy volunteers: No
last name: Sedat Akbas, Asst. Prof.
role: Principal Investigator
affiliation: Inonu University Medical Faculty
facility: 
country: Turkey
citation: Han C, Ding W, Jiang W, Chen YU, Hang D, Gu D, Jiang G, Tan Y, Ge Z, Ma T. A comparison of the effects of midazolam, propofol and dexmedetomidine on the antioxidant system: A randomized trial. Exp Ther Med. 2015 Jun;9(6):2293-2298. doi: 10.3892/etm.2015.2410. Epub 2015 Apr 7.
PMID: 26136976
responsible party type: Principal Investigator
investigator affiliation: Inonu University
investigator full name: Sedat AKBAS
investigator title: Asst. Prof. Dr. Sedat Akbas
mesh term: Obesity, Morbid
mesh term: Antioxidants
sharing ipd: No
provided document: 