<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03834558</url>
  </required_header>
  <id_info>
    <org_study_id>H1488746567568</org_study_id>
    <nct_id>NCT03834558</nct_id>
  </id_info>
  <brief_title>Imaging Biomarkers of the Effects of a Mixed Exercise Program</brief_title>
  <acronym>SarcoImage</acronym>
  <official_title>SarcoImage: Anatomical and Physiological Validation by Magnetic Resonance Imaging Biomarkers of the Effects of High Intensity Strenght Training and Myofascial Self-conditioning on Sarcopenia in Frail and Prefrail Elderly</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Valencia</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Fundación Universidad Católica de Valencia San Vicente Mártir</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Quironsalud</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Valencia</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The aim is quantify, correlate and establish the diagnostic and prognostic value of the&#xD;
      variation of the image biomarkers obtained by magnetic resonance (muscle volume,&#xD;
      morphological, biochemical and structural biomarkers) longitudinally in fragile or pre-frail&#xD;
      elders with sarcopenia after a mixed physical training of strength and myofascial&#xD;
      self-conditioning. This project is based on an, longitudinal, prospective, controlled,&#xD;
      randomized, intervention study and blind for the researchers responsible for the study. 60&#xD;
      elderly with sarcopenia and frailty (Intervention Group, n=30; Control Group, n=30) will&#xD;
      participate in the study. Intervention Group participants will perform 6-months mixed&#xD;
      exercise program consisting in high-intensity strength training and self-myofascial&#xD;
      conditioning. Data will be take trough 2 measurements that will be take place at baseline and&#xD;
      post-intervention. Criteria of frailty, criteria of sarcopenia, sociodemographic, clinics,&#xD;
      kinanthropometric, functional, nutritional and confusing variables will be evaluated.&#xD;
      Moreover, magnetic resonance images will be performed to obtain muscle volume, morphological,&#xD;
      biochemical and structural biomarkers.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">February 6, 2019</start_date>
  <completion_date type="Actual">November 2, 2020</completion_date>
  <primary_completion_date type="Actual">April 15, 2020</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>This project is based on an, longitudinal, prospective, controlled, randomized, intervention study and blind for the researchers responsible for the study. Thus, the subjects participating in the study will be divided into 2 groups, one of which will perform the mixed exercise program (intervention group, IG), and another that will follow their daily routine without added exercise (control group, CG).&#xD;
Each group will have 2 measurements in which the corresponding variables will be evaluated: A) before the start of the intervention, B) at 6 months (at the end of the intervention)</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Investigator, Outcomes Assessor)</masking>
    <masking_description>Investigator: The persons who make the data analysis and decide whether a patient has experienced an outcome of interest will be masked.&#xD;
Outcome assessors: The persons who assess patients and provide outcome data will be masked.</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Muscle volume</measure>
    <time_frame>6 months</time_frame>
    <description>Changes related to macroscopic changes in muscle tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically muscle volume of the thigh by compartment - anterior, medial and posterior (in ml)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Bone volume</measure>
    <time_frame>6 months</time_frame>
    <description>Changes related to macroscopic changes in bone tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically relative volume of bone (in %)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Relative volume of intramuscular fat</measure>
    <time_frame>6 months</time_frame>
    <description>Changes related to macroscopic changes in fat tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically relative volume of intramuscular fat (in %)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Extramuscular subcutaneous fat</measure>
    <time_frame>6 months</time_frame>
    <description>Changes related to macroscopic changes in fat tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically extramuscular subcutaneous fat (in ml)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Microscopic fat fraction</measure>
    <time_frame>6 months</time_frame>
    <description>Changes related to microscopic changes in fat tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically microscopic fat fraction (in %)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Descriptors of muscle texture</measure>
    <time_frame>6 months</time_frame>
    <description>Changes related to microscopic changes in muscle tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically statistical descriptors of muscle texture: energy, entropy, contrast and homogeneity (adimensional)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Diffusion coefficient</measure>
    <time_frame>6 months</time_frame>
    <description>Changes related to microscopic changes in diffusion coefficient assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically diffusion coefficient and apparent diffusion coefficient (mm2/s)</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Body muscle mass</measure>
    <time_frame>6 months</time_frame>
    <description>Changes produced by 6-month program of high intensity training and myofascial self-conditioning on body muscle mass (kg/m2) measured according to criteria of sarcopenia of European Working Group of Sarcopenia in Older People.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Handgrip strength</measure>
    <time_frame>6 months</time_frame>
    <description>Changes produced by 6-month program of high intensity training and myofascial self-conditioning on handgrip strength (kg) measured according to criteria of sarcopenia of European Working Group of Sarcopenia in Older People.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Walking speed</measure>
    <time_frame>6 months</time_frame>
    <description>Changes produced by 6-month program of high intensity training and myofascial self-conditioning on walking speed (m/s) measured according to criteria of sarcopenia of European Working Group of Sarcopenia in Older People.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Body mass index</measure>
    <time_frame>6 months</time_frame>
    <description>Changes on body mass index (measured in kg/m2) generated by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Lean mass</measure>
    <time_frame>6 months</time_frame>
    <description>Changes on lean impedance (measured in % by bioimpedance) generated by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Fat mass</measure>
    <time_frame>6 months</time_frame>
    <description>Changes on fat impedance (measured in % by bioimpedance) generated by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Body perimeters</measure>
    <time_frame>6 months</time_frame>
    <description>Changes on calf and thigh perimeter (measured in cm) generated by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Articular range</measure>
    <time_frame>6 months</time_frame>
    <description>Changes on range of joint movement of coxofemoral and knee articulation (measured in degrees) generated by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Perceived pain</measure>
    <time_frame>6 months</time_frame>
    <description>Changes on pain (measured by visual analogic scale, 0 to 10 points, higher values = worse outcome) generated by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Activities of daily living</measure>
    <time_frame>6 months</time_frame>
    <description>Changes in functionality and independence measured by Barthel Index (0 to 100 points, &lt; 60 dependence, higher values = better outcome) produced by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Functional and physical performance</measure>
    <time_frame>6 months</time_frame>
    <description>Changes in functional and physical performance measured by Short Physical Performance Battery (0 to 12 points, higher score = higher function) produced by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Forced spirometry</measure>
    <time_frame>6 months</time_frame>
    <description>Changes in respiratory function, measured by forced spirometry parameters assessed with a spirometer, produced by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Respiratory muscles strength</measure>
    <time_frame>6 months</time_frame>
    <description>Changes in respiratory pressures generated in mouth by respiratory muscles (assessed with a respiratory pressure gauge) produced by 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Perceived quality of life</measure>
    <time_frame>6 months</time_frame>
    <description>Changes produced by 6-month program of high intensity training and myofascial self-conditioning related to quality of life (EuroQol 5 Dimensions - 3 levels Index, 0 to 1 points, higher values = better outcome)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Type of drugs used</measure>
    <time_frame>6 months</time_frame>
    <description>Type and dose of drugs consumed before and after a 6-month program of high intensity training and myofascial self-conditioning</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">60</enrollment>
  <condition>Sarcopenia</condition>
  <arm_group>
    <arm_group_label>Control Group</arm_group_label>
    <arm_group_type>No Intervention</arm_group_type>
    <description>They will follow their daily routine without added exercise</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Intervention Group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>They will perform the mixed exercise program</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Mixed exercise program</intervention_name>
    <description>A progressive program of high intensity strength and myofascial conditioning will be carried out in 2 non-consecutive weekly sessions (24 weeks). Each session will include:&#xD;
A) Warm up on a cycle ergometer&#xD;
B) Strength circuit: 6 exercises will be included to strengthen different muscle groups (2 in the upper extremities, 2 in the trunk and 2 in the lower extremities). 3 sets of 10-15 repetitions until the failure. The load will be set to 70% of 1 maximal resistance.&#xD;
C) Self-myofascial conditioning: 10 repetitions, in the direction of the fibres of each muscle group, with different materials. 7 muscle groups will be worked (quadriceps, hamstrings, abductors, gluteus, pectoralis, full back and trapezius).&#xD;
D) At the end, static stretches will be performed</description>
    <arm_group_label>Intervention Group</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patients of both genders,&#xD;
&#xD;
          -  aged 70 years old or more,&#xD;
&#xD;
          -  with habitual residence in Valencia,&#xD;
&#xD;
          -  with independent wandering (they can have technical aids, but not from someone else)&#xD;
&#xD;
          -  that meets Fried's pre-frailty or frailty criteria&#xD;
&#xD;
          -  EGWSOP's sarcopenia criteria&#xD;
&#xD;
          -  who has agreed to participate in the study and signed the informed consent&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Patients with life expectancy less than six months&#xD;
&#xD;
          -  Institutionalized patients&#xD;
&#xD;
          -  Patients with severe visual or auditory deficits&#xD;
&#xD;
          -  Patients with contraindication in the performance of physical exercise (cardiovascular&#xD;
             risk factors)&#xD;
&#xD;
          -  Patients with contraindications for the magnetic resonance study, especially carriers&#xD;
             of non-compatible pacemakers, neurostimulators, cochlear implants and intracranial&#xD;
             aneurysm clamping.&#xD;
&#xD;
          -  Patients with severe psychiatric illness or moderate or severe cognitive impairment.&#xD;
&#xD;
          -  Patients who refuse to sign the informed consent.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>70 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Francisco Martinez Arnau, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Universitat de Valencia</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Roberto Sanz Requena, PhD</last_name>
    <role>Study Director</role>
    <affiliation>Hospital QuironSalud - Hospital Universitario La Fe (GIBI)</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Ana Pablos Monzó, PhD</last_name>
    <role>Study Director</role>
    <affiliation>Fundación Universidad Católica de Valencia</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Pilar Pérez-Ros, PhD</last_name>
    <role>Study Director</role>
    <affiliation>Fundación Universidad Católica de Valencia</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>University of Valencia - Faculty of Physiotherapy</name>
      <address>
        <city>Valencia</city>
        <zip>46009</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Spain</country>
  </location_countries>
  <verification_date>November 2020</verification_date>
  <study_first_submitted>September 24, 2018</study_first_submitted>
  <study_first_submitted_qc>February 5, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">February 8, 2019</study_first_posted>
  <last_update_submitted>November 2, 2020</last_update_submitted>
  <last_update_submitted_qc>November 2, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">November 3, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>University of Valencia</investigator_affiliation>
    <investigator_full_name>Francisco Martínez Arnau</investigator_full_name>
    <investigator_title>Martínez-Arnau FM, PT, PhD</investigator_title>
  </responsible_party>
  <keyword>Sarcopenia</keyword>
  <keyword>Frailty</keyword>
  <keyword>Strength</keyword>
  <keyword>myofascial self conditioning</keyword>
  <keyword>image biomarkers</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Sarcopenia</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
    <ipd_description>No data will be shared with other researchers</ipd_description>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03834558
org study id: H1488746567568
nct id: NCT03834558
lead sponsor: 
collaborator: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
The aim is quantify, correlate and establish the diagnostic and prognostic value of the
      variation of the image biomarkers obtained by magnetic resonance (muscle volume,
      morphological, biochemical and structural biomarkers) longitudinally in fragile or pre-frail
      elders with sarcopenia after a mixed physical training of strength and myofascial
      self-conditioning. This project is based on an, longitudinal, prospective, controlled,
      randomized, intervention study and blind for the researchers responsible for the study. 60
      elderly with sarcopenia and frailty (Intervention Group, n=30; Control Group, n=30) will
      participate in the study. Intervention Group participants will perform 6-months mixed
      exercise program consisting in high-intensity strength training and self-myofascial
      conditioning. Data will be take trough 2 measurements that will be take place at baseline and
      post-intervention. Criteria of frailty, criteria of sarcopenia, sociodemographic, clinics,
      kinanthropometric, functional, nutritional and confusing variables will be evaluated.
      Moreover, magnetic resonance images will be performed to obtain muscle volume, morphological,
      biochemical and structural biomarkers.
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: This project is based on an, longitudinal, prospective, controlled, randomized, intervention study and blind for the researchers responsible for the study. Thus, the subjects participating in the study will be divided into 2 groups, one of which will perform the mixed exercise program (intervention group, IG), and another that will follow their daily routine without added exercise (control group, CG).
Each group will have 2 measurements in which the corresponding variables will be evaluated: A) before the start of the intervention, B) at 6 months (at the end of the intervention)
primary purpose: Treatment
masking: Double (Investigator, Outcomes Assessor)
masking description: Investigator: The persons who make the data analysis and decide whether a patient has experienced an outcome of interest will be masked.
Outcome assessors: The persons who assess patients and provide outcome data will be masked.
measure: Muscle volume
time frame: 6 months
description: Changes related to macroscopic changes in muscle tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically muscle volume of the thigh by compartment - anterior, medial and posterior (in ml)
measure: Bone volume
time frame: 6 months
description: Changes related to macroscopic changes in bone tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically relative volume of bone (in %)
measure: Relative volume of intramuscular fat
time frame: 6 months
description: Changes related to macroscopic changes in fat tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically relative volume of intramuscular fat (in %)
measure: Extramuscular subcutaneous fat
time frame: 6 months
description: Changes related to macroscopic changes in fat tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically extramuscular subcutaneous fat (in ml)
measure: Microscopic fat fraction
time frame: 6 months
description: Changes related to microscopic changes in fat tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically microscopic fat fraction (in %)
measure: Descriptors of muscle texture
time frame: 6 months
description: Changes related to microscopic changes in muscle tissue assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically statistical descriptors of muscle texture: energy, entropy, contrast and homogeneity (adimensional)
measure: Diffusion coefficient
time frame: 6 months
description: Changes related to microscopic changes in diffusion coefficient assessed by magnetic resonance after a 6-month program of high intensity training and myofascial self-conditioning, specifically diffusion coefficient and apparent diffusion coefficient (mm2/s)
measure: Body muscle mass
time frame: 6 months
description: Changes produced by 6-month program of high intensity training and myofascial self-conditioning on body muscle mass (kg/m2) measured according to criteria of sarcopenia of European Working Group of Sarcopenia in Older People.
measure: Handgrip strength
time frame: 6 months
description: Changes produced by 6-month program of high intensity training and myofascial self-conditioning on handgrip strength (kg) measured according to criteria of sarcopenia of European Working Group of Sarcopenia in Older People.
measure: Walking speed
time frame: 6 months
description: Changes produced by 6-month program of high intensity training and myofascial self-conditioning on walking speed (m/s) measured according to criteria of sarcopenia of European Working Group of Sarcopenia in Older People.
measure: Body mass index
time frame: 6 months
description: Changes on body mass index (measured in kg/m2) generated by 6-month program of high intensity training and myofascial self-conditioning
measure: Lean mass
time frame: 6 months
description: Changes on lean impedance (measured in % by bioimpedance) generated by 6-month program of high intensity training and myofascial self-conditioning
measure: Fat mass
time frame: 6 months
description: Changes on fat impedance (measured in % by bioimpedance) generated by 6-month program of high intensity training and myofascial self-conditioning
measure: Body perimeters
time frame: 6 months
description: Changes on calf and thigh perimeter (measured in cm) generated by 6-month program of high intensity training and myofascial self-conditioning
measure: Articular range
time frame: 6 months
description: Changes on range of joint movement of coxofemoral and knee articulation (measured in degrees) generated by 6-month program of high intensity training and myofascial self-conditioning
measure: Perceived pain
time frame: 6 months
description: Changes on pain (measured by visual analogic scale, 0 to 10 points, higher values = worse outcome) generated by 6-month program of high intensity training and myofascial self-conditioning
measure: Activities of daily living
time frame: 6 months
description: Changes in functionality and independence measured by Barthel Index (0 to 100 points, < 60 dependence, higher values = better outcome) produced by 6-month program of high intensity training and myofascial self-conditioning
measure: Functional and physical performance
time frame: 6 months
description: Changes in functional and physical performance measured by Short Physical Performance Battery (0 to 12 points, higher score = higher function) produced by 6-month program of high intensity training and myofascial self-conditioning
measure: Forced spirometry
time frame: 6 months
description: Changes in respiratory function, measured by forced spirometry parameters assessed with a spirometer, produced by 6-month program of high intensity training and myofascial self-conditioning
measure: Respiratory muscles strength
time frame: 6 months
description: Changes in respiratory pressures generated in mouth by respiratory muscles (assessed with a respiratory pressure gauge) produced by 6-month program of high intensity training and myofascial self-conditioning
measure: Perceived quality of life
time frame: 6 months
description: Changes produced by 6-month program of high intensity training and myofascial self-conditioning related to quality of life (EuroQol 5 Dimensions - 3 levels Index, 0 to 1 points, higher values = better outcome)
measure: Type of drugs used
time frame: 6 months
description: Type and dose of drugs consumed before and after a 6-month program of high intensity training and myofascial self-conditioning
arm group label: Control Group
arm group type: No Intervention
description: They will follow their daily routine without added exercise
arm group label: Intervention Group
arm group type: Experimental
description: They will perform the mixed exercise program
intervention type: Other
intervention name: Mixed exercise program
description: A progressive program of high intensity strength and myofascial conditioning will be carried out in 2 non-consecutive weekly sessions (24 weeks). Each session will include:
A) Warm up on a cycle ergometer
B) Strength circuit: 6 exercises will be included to strengthen different muscle groups (2 in the upper extremities, 2 in the trunk and 2 in the lower extremities). 3 sets of 10-15 repetitions until the failure. The load will be set to 70% of 1 maximal resistance.
C) Self-myofascial conditioning: 10 repetitions, in the direction of the fibres of each muscle group, with different materials. 7 muscle groups will be worked (quadriceps, hamstrings, abductors, gluteus, pectoralis, full back and trapezius).
D) At the end, static stretches will be performed
arm group label: Intervention Group
criteria: 
gender: All
minimum age: 70 Years
maximum age: N/A
healthy volunteers: No
last name: Francisco Martinez Arnau, PhD
role: Principal Investigator
affiliation: Universitat de Valencia
last name: Roberto Sanz Requena, PhD
role: Study Director
affiliation: Hospital QuironSalud - Hospital Universitario La Fe (GIBI)
last name: Ana Pablos Monzó, PhD
role: Study Director
affiliation: Fundación Universidad Católica de Valencia
last name: Pilar Pérez-Ros, PhD
role: Study Director
affiliation: Fundación Universidad Católica de Valencia
facility: 
country: Spain
responsible party type: Principal Investigator
investigator affiliation: University of Valencia
investigator full name: Francisco Martínez Arnau
investigator title: Martínez-Arnau FM, PT, PhD
mesh term: Sarcopenia
sharing ipd: No
ipd description: No data will be shared with other researchers