<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03800836</url>
  </required_header>
  <id_info>
    <org_study_id>CO40151</org_study_id>
    <secondary_id>2017-001957-15</secondary_id>
    <nct_id>NCT03800836</nct_id>
  </id_info>
  <brief_title>A Study to Evaluate the Safety and Efficacy of Ipatasertib in Combination With Atezolizumab and Paclitaxel or Nab-Paclitaxel in Participants With Locally Advanced or Metastatic Triple-Negative Breast Cancer</brief_title>
  <official_title>A Phase Ib, Open-Label, Multicenter Study Evaluating the Safety and Efficacy of Ipatasertib in Combination With Atezolizumab and Paclitaxel or Nab-Paclitaxel in Patients With Locally Advanced or Metastatic Triple-Negative Breast Cancer</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Hoffmann-La Roche</agency>
      <agency_class>Industry</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Hoffmann-La Roche</source>
  <oversight_info>
    <is_fda_regulated_drug>Yes</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This is a study consisting of four cohorts in this setting. In Cohort 1, the safety and&#xD;
      efficacy of ipatasertib (ipat) in combination with atezolizumab (atezo) and paclitaxel (pac)&#xD;
      or nab-paclitaxel will be evaluated for participants with locally advanced or metastatic&#xD;
      triple-negative breast cancer (TNBC) who have not previously received chemotherapy. In Cohort&#xD;
      2, ipatasertib and atezolizumab (with no chemotherapy), will be administered to participants&#xD;
      with locally advanced or metastatic TNBC. In Cohort 3, the safety and efficacy of neoadjuvant&#xD;
      ipatasertib, atezolizumab, doxorubicin and cyclophosphamide (AC) (Ipat + Atezo + AC) followed&#xD;
      by Ipat + Atezo + Pac will be evaluated in participants with locally advanced Type 2-4 (T2-4)&#xD;
      TNBC. In Cohort 4, the safety and efficacy of Ipat + Atezo + Pac will be evaluated in&#xD;
      participants with PD-L1 (Programmed Death-Ligand-1) positive locally advanced or metastatic&#xD;
      TNBC that is not amenable to resection and who have not previously received chemotherapy in&#xD;
      the advanced setting.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">February 13, 2018</start_date>
  <completion_date type="Actual">March 15, 2022</completion_date>
  <primary_completion_date type="Actual">March 15, 2022</primary_completion_date>
  <phase>Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Non-Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Cohort 1 and Cohort 4: Percentage of Participants with Objective Response (Complete Response [CR] or Partial Response [PR]), as Assessed by Investigator Based on Response Evaluation Criteria in Solid Tumors (RECIST), Version (v) 1.1</measure>
    <time_frame>Baseline up to disease progression or treatment discontinuation, whichever occurs first (to approximately 12 months)</time_frame>
  </primary_outcome>
  <primary_outcome>
    <measure>Cohort 1 and Cohort 4: Duration of Confirmed Objective Response, as Determined by the Investigator According to RECIST v1.1</measure>
    <time_frame>Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)</time_frame>
  </primary_outcome>
  <primary_outcome>
    <measure>Pathological complete response (pCR) rate defined as the percentage of participants who have no residual invasive disease in the breast and no residual disease in the lymph node.</measure>
    <time_frame>Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)</time_frame>
  </primary_outcome>
  <secondary_outcome>
    <measure>Cohort 1 and Cohort 4: Progression-Free Survival, as Assessed by Investigator Based on RECIST v1.1</measure>
    <time_frame>Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cohort 1 and Cohort 4: Percentage of Participants who have an Objective Response (Complete or Partial), or Stable Disease for at least 24 weeks, as Assessed by Investigator Based on RECIST v1.1</measure>
    <time_frame>Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cohort 1 and Cohort 4: Overall Survival in All Participants</measure>
    <time_frame>Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cohort 1 and Cohort 4: Plasma Concentration of Ipatasertib</measure>
    <time_frame>At Day 15 of Cycles 1-3 (each cycle is 28 days)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cohort 1, Cohort 3 and Cohort 4: Plasma Concentration of Ipatasertib's Metabolite (G-037720)</measure>
    <time_frame>At Day 15 of Cycles 1-3 (each cycle is 28 days)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cohort 1, Cohort 3 and Cohort 4: Presence of Anti-Drug Antibody During Study Treatment</measure>
    <time_frame>At Day 1 and Day 15 of Cycle 1 and Day 1 of succeeding cycles (each cycle is 28 days)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cohort 1, Cohort 3 and Cohort 4: Plasma Concentration of Atezolizumab</measure>
    <time_frame>At Day 1 and Day 15 of Cycle 1 and Day 1 of succeeding cycles (each cycle is 28 days)</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cohort 1, Cohort 2, Cohort 3 and Cohort 4: Percentage of Participants with Adverse Events</measure>
    <time_frame>Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)</time_frame>
  </secondary_outcome>
  <number_of_arms>15</number_of_arms>
  <enrollment type="Actual">140</enrollment>
  <condition>Breast Cancer</condition>
  <arm_group>
    <arm_group_label>Arm A1: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Safety Run-In (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by intravenous (IV) infusion on Days 1 and 15 of each 28 day cycle. Paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm A2: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Expansion (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by intravenous (IV) infusion on Days 1 and 15 of each 28 day cycle. Paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm A3: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Expansion (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by intravenous (IV) infusion on Days 1 and 15 of each 28 day cycle. Paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm B1: Ipat + Atezo + Nab-Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Safety Run-In (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by IV infusion on Days 1 and 15 of each 28 day cycle. Nab-paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm B2: Ipat + Atezo + Nab-Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Expansion (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by IV infusion on Days 1 and 15 of each 28 day cycle. Nab-paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm C1: (Ipat + Pacl) (2 weeks) + Atezo</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Safety Run-In (Cohort 1): Participants will receive a 2-week lead in of ipatasertib in combination with paclitaxel, followed by atezolizumab in an initial 28-day (1 cycle) period. Ipatasertib will be administered orally daily on Days 1-21, with paclitaxel administered by IV infusion on Days 1, 8 and 15. Atezolizumab will be administered by IV infusion on Day 15. In all subsequent treatment cycles, ipatasertib will be administered orally daily on Days 1-21, paclitaxel will be administered by IV infusion on Days 1, 8, and 15 and atezolizumab will be administered by IV infusion on Days 1 and 15. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm C2 (Ipat + Pacl) (2 weeks) + Atezo</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Expansion (Cohort 1): Participants will receive a 2-week lead in of ipatasertib in combination with paclitaxel, followed by atezolizumab in an initial 28-day (1 cycle) period. Ipatasertib will be administered orally daily on Days 1-21, with paclitaxel administered by IV infusion on Days 1, 8 and 15. Atezolizumab will be administered by IV infusion on Day 15. In all subsequent treatment cycles, ipatasertib will be administered orally daily on Days 1-21, paclitaxel will be administered by IV infusion on Days 1, 8, and 15 and atezolizumab will be administered by IV infusion on Days 1 and 15. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm D1: (Atezo + Pacl) (2 weeks) + Ipat</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Safety Run-In (Cohort 1): Participants will receive a 2-week lead in of atezolizumab in combination with paclitaxel, followed by ipatasertib in an initial 28-day (1 cycle) period. Atezolizumab will be administered via IV infusion on Days 1 and 15, with paclitaxel administered by IV infusion on Days 1, 8 and 15. Ipatasertib will be administered orally daily on Days 15-21. In all subsequent treatment cycles, ipatasertib will be administered orally daily on Days 1-21, paclitaxel will be administered by IV infusion on Days 1, 8, and 15 and atezolizumab will be administered by IV infusion on Days 1 and 15. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm D2: (Atezo + Pacl) (2 weeks) + Ipat</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Expansion (Cohort 1): Participants will receive a 2-week lead in of atezolizumab in combination with paclitaxel, followed by ipatasertib in an initial 28-day (1 cycle) period. Atezolizumab will be administered via IV infusion on Days 1 and 15, with paclitaxel administered by IV infusion on Days 1, 8 and 15. Ipatasertib will be administered orally daily on Days 15-21. In all subsequent treatment cycles, ipatasertib will be administered orally daily on Days 1-21, paclitaxel will be administered by IV infusion on Days 1, 8, and 15 and atezolizumab will be administered by IV infusion on Days 1 and 15. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm E: Ipat + Atezo</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Participants (Cohort 2) will receive Ipatasertib orally daily on Days 1-28 of Cycle 1 (35-day cycle) and on Days 1-21 of subsequent cycles (28-day cycles). Atezolizumab will be administered by IV infusion on Days 8 and 22 of Cycle 1 and on Days 1 and 15 of subsequent cycles. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Safety Run-In (Cohort 3): Participants will receive in Cycles 1 and 2 (28 day cycles), Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15 and AC (Doxorubicin and Cyclophosphamide) via IV infusion on Days 1 and 15. In Cycles 3-5, participants will receive Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15, with Paclitaxel administered by IV infusion on Days 1, 8, 15 and 22. All participants in this cohort will continue to be treated for five cycles (28-day cycles; 20 weeks) or until disease progression or unacceptable toxicity, whichever occurs first.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Expansion (Cohort 3): Participants will receive in Cycles 1 and 2 (28 day cycles), Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15 and AC (Doxorubicin and Cyclophosphamide) via IV infusion on Days 1 and 15. In Cycles 3-5, participants will receive Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15, with Paclitaxel administered by IV infusion on Days 1, 8, 15 and 22. All participants in this cohort will continue to be treated for five cycles (28-day cycles; 20 weeks) or until disease progression or unacceptable toxicity, whichever occurs first.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Safety Run-In (Cohort 3): Participants will receive in Cycles 1 and 2 (28 day cycles), Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15 and AC (Doxorubicin and Cyclophosphamide) via IV infusion on Days 1 and 15. In Cycles 3-5, participants will receive Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15, with Paclitaxel administered by IV infusion on Days 1, 8, 15 and 22. All participants in this cohort will continue to be treated for five cycles (28-day cycles; 20 weeks) or until disease progression or unacceptable toxicity, whichever occurs first.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Expansion (Cohort 3): Participants will receive in Cycles 1 and 2 (28 day cycles), Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15 and AC (Doxorubicin and Cyclophosphamide) via IV infusion on Days 1 and 15. In Cycles 3-5, participants will receive Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15, with Paclitaxel administered by IV infusion on Days 1, 8, 15 and 22. All participants in this cohort will continue to be treated for five cycles (28-day cycles; 20 weeks) or until disease progression or unacceptable toxicity, whichever occurs first.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Arm H: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Participants (Cohort 4) will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by intravenous (IV) infusion on Days 1 and 15 of each 28 day cycle. Paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Ipatasertib</intervention_name>
    <description>Ipatasertib will be administered at a dose of 400 milligrams (mg) orally daily on Days 1-21 of each 28 day cycle for all arms except for arms F1/F2 where it will be administered at a dose of 300 milligrams (mg) orally daily for the first two cycles and 400 mg for the remaining three cycles.</description>
    <arm_group_label>Arm A1: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm A2: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm A3: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm B1: Ipat + Atezo + Nab-Pacl</arm_group_label>
    <arm_group_label>Arm B2: Ipat + Atezo + Nab-Pacl</arm_group_label>
    <arm_group_label>Arm C1: (Ipat + Pacl) (2 weeks) + Atezo</arm_group_label>
    <arm_group_label>Arm C2 (Ipat + Pacl) (2 weeks) + Atezo</arm_group_label>
    <arm_group_label>Arm D1: (Atezo + Pacl) (2 weeks) + Ipat</arm_group_label>
    <arm_group_label>Arm D2: (Atezo + Pacl) (2 weeks) + Ipat</arm_group_label>
    <arm_group_label>Arm E: Ipat + Atezo</arm_group_label>
    <arm_group_label>Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm H: Ipat + Atezo + Pacl</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Paclitaxel</intervention_name>
    <description>Paclitaxel will be administered at a dose of 80 milligrams per square meter (mg/m^2) as IV infusion on Days 1, 8, and 15 of each 28 day cycle for all arms, with the exceptions of Arms F1, F2, G1 and G2, where it will be also administered on Day 22 as well, of each 28 day cycle.</description>
    <arm_group_label>Arm A1: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm A2: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm A3: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm C1: (Ipat + Pacl) (2 weeks) + Atezo</arm_group_label>
    <arm_group_label>Arm C2 (Ipat + Pacl) (2 weeks) + Atezo</arm_group_label>
    <arm_group_label>Arm D1: (Atezo + Pacl) (2 weeks) + Ipat</arm_group_label>
    <arm_group_label>Arm D2: (Atezo + Pacl) (2 weeks) + Ipat</arm_group_label>
    <arm_group_label>Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm H: Ipat + Atezo + Pacl</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Atezolizumab</intervention_name>
    <description>Atezolizumab will be administered by IV infusion at a fixed dose of 840 mg on Days 1 and 15 of each 28 day cycle for all arms, although in Arms C1/C2, it will be administered on Day 15 of Cycle 1 followed by Days 1 and 15 in subsequent cycles.</description>
    <arm_group_label>Arm A1: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm A2: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm A3: Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm B1: Ipat + Atezo + Nab-Pacl</arm_group_label>
    <arm_group_label>Arm B2: Ipat + Atezo + Nab-Pacl</arm_group_label>
    <arm_group_label>Arm C1: (Ipat + Pacl) (2 weeks) + Atezo</arm_group_label>
    <arm_group_label>Arm C2 (Ipat + Pacl) (2 weeks) + Atezo</arm_group_label>
    <arm_group_label>Arm D1: (Atezo + Pacl) (2 weeks) + Ipat</arm_group_label>
    <arm_group_label>Arm D2: (Atezo + Pacl) (2 weeks) + Ipat</arm_group_label>
    <arm_group_label>Arm E: Ipat + Atezo</arm_group_label>
    <arm_group_label>Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm H: Ipat + Atezo + Pacl</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Nab-Paclitaxel</intervention_name>
    <description>Nab-paclitaxel will be administered by IV infusion at a dose of 100 mg/m^2 on Days 1, 8, and 15 of each 28 day cycle.</description>
    <arm_group_label>Arm B1: Ipat + Atezo + Nab-Pacl</arm_group_label>
    <arm_group_label>Arm B2: Ipat + Atezo + Nab-Pacl</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>AC</intervention_name>
    <description>AC (Doxorubicin and Cyclophosphamide) will be administered by IV infusion at 60 mg/m^2 and 600 mg/m^2 respectively on Days 1 and 15 of Cycles 1 and 2 for Arms F1, F2, G1 and G2.</description>
    <arm_group_label>Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
    <arm_group_label>Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
        General:&#xD;
&#xD;
          -  Eastern Cooperative Oncology Group Performance Status of 0 or 1.&#xD;
&#xD;
          -  Adequate hematologic and organ function.&#xD;
&#xD;
          -  For Cohorts 1, 2 and 4: Life expectancy of at least 6 months.&#xD;
&#xD;
          -  For men and women of child bearing potential: agreement to remain abstinent or use&#xD;
             protocol defined contraceptive measures during the treatment period and for at least&#xD;
             28 days after the last dose of ipatasertib, 6 months after the last dose of&#xD;
             paclitaxel, nab-paclitaxel, or doxorubicin, and 12 months after the last dose of&#xD;
             cyclophosphamide, and 5 months after the last dose of atezolizumab, whichever occurs&#xD;
             later along with refraining from donating sperm or eggs during this same period.&#xD;
&#xD;
        Disease-specific:&#xD;
&#xD;
          -  For Cohorts 1, 2 and 4: histologically documented TNBC that is locally advanced or&#xD;
             metastatic and is not amenable to resection with curative intent.&#xD;
&#xD;
          -  For Cohort 2: disease progression following one or two lines of systemic therapy for&#xD;
             inoperable locally advanced or metastatic TNBC.&#xD;
&#xD;
          -  For Cohorts 1, 2 and 4: measurable disease according to RECIST v1.1 criteria.&#xD;
&#xD;
          -  For Cohort 2: Treated brain or spinal cord metastases are allowed if participants have&#xD;
             stable disease and are not on steroid treatment.&#xD;
&#xD;
          -  For Cohort 3: histologically documented TNBC with a primary breast tumour size of &gt; 2&#xD;
             cm by at least one radiographic or clinical measurement and disease stage at&#xD;
             presentation of cT2-4 cN0-3 cM0.&#xD;
&#xD;
          -  For Cohort 3: participant agreement to undergo appropriate surgical management,&#xD;
             including axillary lymph node surgery and partial or total mastectomy, after&#xD;
             completion of neoadjuvant treatment.&#xD;
&#xD;
          -  For Cohort 4: participants must have centrally confirmed PD-L1-positive tumour.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
        General:&#xD;
&#xD;
          -  History of malabsorption syndrome or other condition that would interfere with enteral&#xD;
             absorption or results in the inability or unwillingness to swallow pills.&#xD;
&#xD;
          -  Active infection requiring antibiotics.&#xD;
&#xD;
          -  History of or current evidence of HIV infection.&#xD;
&#xD;
          -  Known clinically significant history of liver disease.&#xD;
&#xD;
          -  Major surgical procedure, open biopsy, or significant traumatic injury within 28 days&#xD;
             prior to Day 1 of Cycle 1 or anticipation of need for a major surgical procedure&#xD;
             (other than anticipated breast surgery for Cohort 3) during the course of the study.&#xD;
&#xD;
          -  Pregnant or breastfeeding.&#xD;
&#xD;
          -  New York Heart Association (NYHA) Class II, III, or IV heart failure; left ventricular&#xD;
             ejection fraction &lt; 50%; or active ventricular arrhythmia requiring medication.&#xD;
&#xD;
          -  Treatment with approved or investigational cancer therapy within 14 days prior to Day&#xD;
             1 of Cycle 1.&#xD;
&#xD;
          -  Prior treatment with an Akt inhibitor.&#xD;
&#xD;
        Disease-specific:&#xD;
&#xD;
          -  For Cohorts 1 and 4: history of or known presence of brain or spinal cord metastases.&#xD;
&#xD;
          -  For Cohorts 1 and 4: participants who have received previous systemic therapy for&#xD;
             inoperable locally advanced or metastatic TNBC, including chemotherapy, immune&#xD;
             checkpoint inhibitors, or targeted agents.&#xD;
&#xD;
          -  Unresolved, clinically significant toxicity from prior therapy, except for alopecia&#xD;
             and Grade 1 peripheral neuropathy.&#xD;
&#xD;
          -  Participants who have received palliative radiation treatment to peripheral sites&#xD;
             (e.g., bone metastases) for pain control and whose last treatment was completed 14&#xD;
             days prior to Day 1 of Cycle 1 and have recovered from all acute, reversible effects.&#xD;
&#xD;
          -  Uncontrolled pleural effusion, pericardial effusion, or ascites.&#xD;
&#xD;
          -  Uncontrolled tumor related complications.&#xD;
&#xD;
          -  Uncontrolled hypercalcaemia or symptomatic hypercalcaemia requiring continued use of&#xD;
             bisphosphonate therapy.&#xD;
&#xD;
          -  Malignancies other than breast cancer within 5 years prior to Day 1 of Cycle 1.&#xD;
&#xD;
          -  For Cohort 3, participants with the following are excluded: [1] prior history of&#xD;
             invasive breast cancer; [2] prior systemic therapy for treatment and/or prevention of&#xD;
             invasive breast cancer; [3] previous therapy with anthracyclines or taxanes for any&#xD;
             malignancy; [4] bilateral breast cancer; [5] undergone incisional and/or excisional&#xD;
             biopsy of primary tumor and/or axillary lymph nodes; [6] undergone axillary lymph node&#xD;
             dissection (ALND) prior to initiation of neoadjuvant therapy; [6] history of other&#xD;
             malignancy within 5 years prior to screening; [7] history of cerebrovascular accident&#xD;
             within 12 months prior to initiation of study treatment; [8] cardiopulmonary&#xD;
             dysfunction; [9] known allergy or hypersensitivity to the components of&#xD;
             cyclophosphamide/doxorubicin formulations and filgrastim or pegfilgrastim&#xD;
             formulations; [10] severe infection within 4 weeks prior to initiation of study&#xD;
             treatment; [11] treatment with therapeutic oral or IV (Intravenous) antibiotics within&#xD;
             2 weeks prior to initiation of study treatment and [12] prior treatment with CD137&#xD;
             agonists or immune checkpoint - blockade therapies.&#xD;
&#xD;
        Ipatasertib-specific:&#xD;
&#xD;
          -  History of Type I or Type II diabetes mellitus requiring insulin.&#xD;
&#xD;
          -  Grade &gt;= 2 uncontrolled or untreated hypercholesterolemia or hypertriglyceridemia.&#xD;
&#xD;
          -  History of or active inflammatory bowel disease or active bowel inflammation.&#xD;
&#xD;
          -  Clinically significant lung disease.&#xD;
&#xD;
          -  Treatment with strong CYP3A inhibitors or strong CYP3A inducers.&#xD;
&#xD;
        Atezolizumab-specific:&#xD;
&#xD;
          -  Active or history of autoimmune disease or immune deficiency.&#xD;
&#xD;
          -  History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis&#xD;
             obliterans), drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active&#xD;
             pneumonitis on screening chest computed tomography (CT) scan.&#xD;
&#xD;
          -  Prior allogeneic stem cell or solid organ transplantation.&#xD;
&#xD;
          -  Treatment with a live, attenuated vaccine within 4 weeks prior to initiation of study&#xD;
             treatment, or anticipation of need for such a vaccine during treatment with&#xD;
             atezolizumab or within 5 months after the last dose of atezolizumab.&#xD;
&#xD;
          -  History of hypersensitivity reactions to study drug or any component of the study drug&#xD;
             formulation.&#xD;
&#xD;
          -  Treatment with systemic immunostimulatory agents and immunosuppressive medication&#xD;
             treatment, or anticipation of need for systemic immunosuppressive medication during&#xD;
             the course of the study.&#xD;
&#xD;
        Paclitaxel-specific:&#xD;
&#xD;
        - Grade &gt;= 2 peripheral neuropathy.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Clinical Trials</last_name>
    <role>Study Director</role>
    <affiliation>Hoffmann-La Roche</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Pacific Shores Medical Group</name>
      <address>
        <city>Long Beach</city>
        <state>California</state>
        <zip>90813</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>St Vincents Hospital; Cardiopulmonary transplant Ambulatory Care Dept</name>
      <address>
        <city>Darlinghurst</city>
        <state>New South Wales</state>
        <zip>2010</zip>
        <country>Australia</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Peter MacCallum Cancer Center</name>
      <address>
        <city>East Melbourne</city>
        <state>Victoria</state>
        <zip>3002</zip>
        <country>Australia</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Austin Hospital</name>
      <address>
        <city>Heidelberg</city>
        <state>Victoria</state>
        <zip>3084</zip>
        <country>Australia</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Institut de Cancerologie de l Ouest</name>
      <address>
        <city>Angers</city>
        <zip>49055</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Institut Bergonie</name>
      <address>
        <city>Bordeaux</city>
        <zip>33076</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Centre Georges Francois Leclerc</name>
      <address>
        <city>Dijon</city>
        <zip>21000</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Institut Curie</name>
      <address>
        <city>Paris</city>
        <zip>75005</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Gustave Roussy</name>
      <address>
        <city>Villejuif CEDEX</city>
        <zip>94800</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Hospital de la Santa Creu i Sant Pau</name>
      <address>
        <city>Barcelona</city>
        <zip>08025</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Hospital Universitario La Paz</name>
      <address>
        <city>Madrid</city>
        <zip>280146</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Hospital Clinico San Carlos; Servicio de Oncologia</name>
      <address>
        <city>Madrid</city>
        <zip>28040</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Hospital Universitario Fundacion Jimenez Diaz.</name>
      <address>
        <city>Madrid</city>
        <zip>28040</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Hospital Universitario 12 de Octubre</name>
      <address>
        <city>Madrid</city>
        <zip>28041</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Centro Integral Oncologico Clara Campal (CIOCC); Dirección Médica</name>
      <address>
        <city>Madrid</city>
        <zip>28050</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Hospital Universitario Virgen del Rocío</name>
      <address>
        <city>Sevilla</city>
        <zip>41013</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Barts Cancer Institute</name>
      <address>
        <city>London</city>
        <zip>E1 2AT</zip>
        <country>United Kingdom</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Nottingham University Hospitals NHS Trust</name>
      <address>
        <city>Nottingham</city>
        <zip>NG7 2UH</zip>
        <country>United Kingdom</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Australia</country>
    <country>France</country>
    <country>Spain</country>
    <country>United Kingdom</country>
    <country>United States</country>
  </location_countries>
  <verification_date>April 2022</verification_date>
  <study_first_submitted>January 7, 2019</study_first_submitted>
  <study_first_submitted_qc>January 9, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">January 11, 2019</study_first_posted>
  <last_update_submitted>April 22, 2022</last_update_submitted>
  <last_update_submitted_qc>April 22, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">April 25, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Breast Neoplasms</mesh_term>
    <mesh_term>Triple Negative Breast Neoplasms</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Paclitaxel</mesh_term>
    <mesh_term>Albumin-Bound Paclitaxel</mesh_term>
    <mesh_term>Atezolizumab</mesh_term>
    <mesh_term>Ipatasertib</mesh_term>
  </intervention_browse>
  <pending_results>
    <submitted>March 15, 2023</submitted>
  </pending_results>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03800836
org study id: CO40151
secondary id: 2017-001957-15
nct id: NCT03800836
lead sponsor: 
is fda regulated drug: Yes
is fda regulated device: No
This is a study consisting of four cohorts in this setting. In Cohort 1, the safety and
      efficacy of ipatasertib (ipat) in combination with atezolizumab (atezo) and paclitaxel (pac)
      or nab-paclitaxel will be evaluated for participants with locally advanced or metastatic
      triple-negative breast cancer (TNBC) who have not previously received chemotherapy. In Cohort
      2, ipatasertib and atezolizumab (with no chemotherapy), will be administered to participants
      with locally advanced or metastatic TNBC. In Cohort 3, the safety and efficacy of neoadjuvant
      ipatasertib, atezolizumab, doxorubicin and cyclophosphamide (AC) (Ipat + Atezo + AC) followed
      by Ipat + Atezo + Pac will be evaluated in participants with locally advanced Type 2-4 (T2-4)
      TNBC. In Cohort 4, the safety and efficacy of Ipat + Atezo + Pac will be evaluated in
      participants with PD-L1 (Programmed Death-Ligand-1) positive locally advanced or metastatic
      TNBC that is not amenable to resection and who have not previously received chemotherapy in
      the advanced setting.
allocation: Non-Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Cohort 1 and Cohort 4: Percentage of Participants with Objective Response (Complete Response [CR] or Partial Response [PR]), as Assessed by Investigator Based on Response Evaluation Criteria in Solid Tumors (RECIST), Version (v) 1.1
time frame: Baseline up to disease progression or treatment discontinuation, whichever occurs first (to approximately 12 months)
measure: Cohort 1 and Cohort 4: Duration of Confirmed Objective Response, as Determined by the Investigator According to RECIST v1.1
time frame: Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)
measure: Pathological complete response (pCR) rate defined as the percentage of participants who have no residual invasive disease in the breast and no residual disease in the lymph node.
time frame: Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)
measure: Cohort 1 and Cohort 4: Progression-Free Survival, as Assessed by Investigator Based on RECIST v1.1
time frame: Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)
measure: Cohort 1 and Cohort 4: Percentage of Participants who have an Objective Response (Complete or Partial), or Stable Disease for at least 24 weeks, as Assessed by Investigator Based on RECIST v1.1
time frame: Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)
measure: Cohort 1 and Cohort 4: Overall Survival in All Participants
time frame: Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)
measure: Cohort 1 and Cohort 4: Plasma Concentration of Ipatasertib
time frame: At Day 15 of Cycles 1-3 (each cycle is 28 days)
measure: Cohort 1, Cohort 3 and Cohort 4: Plasma Concentration of Ipatasertib's Metabolite (G-037720)
time frame: At Day 15 of Cycles 1-3 (each cycle is 28 days)
measure: Cohort 1, Cohort 3 and Cohort 4: Presence of Anti-Drug Antibody During Study Treatment
time frame: At Day 1 and Day 15 of Cycle 1 and Day 1 of succeeding cycles (each cycle is 28 days)
measure: Cohort 1, Cohort 3 and Cohort 4: Plasma Concentration of Atezolizumab
time frame: At Day 1 and Day 15 of Cycle 1 and Day 1 of succeeding cycles (each cycle is 28 days)
measure: Cohort 1, Cohort 2, Cohort 3 and Cohort 4: Percentage of Participants with Adverse Events
time frame: Baseline up to disease progression or death due to any cause whichever occurs first (up to approximately 12 months)
arm group label: Arm A1: Ipat + Atezo + Pacl
arm group type: Experimental
description: Safety Run-In (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by intravenous (IV) infusion on Days 1 and 15 of each 28 day cycle. Paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm A2: Ipat + Atezo + Pacl
arm group type: Experimental
description: Expansion (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by intravenous (IV) infusion on Days 1 and 15 of each 28 day cycle. Paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm A3: Ipat + Atezo + Pacl
arm group type: Experimental
description: Expansion (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by intravenous (IV) infusion on Days 1 and 15 of each 28 day cycle. Paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm B1: Ipat + Atezo + Nab-Pacl
arm group type: Experimental
description: Safety Run-In (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by IV infusion on Days 1 and 15 of each 28 day cycle. Nab-paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm B2: Ipat + Atezo + Nab-Pacl
arm group type: Experimental
description: Expansion (Cohort 1): Participants will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by IV infusion on Days 1 and 15 of each 28 day cycle. Nab-paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm C1: (Ipat + Pacl) (2 weeks) + Atezo
arm group type: Experimental
description: Safety Run-In (Cohort 1): Participants will receive a 2-week lead in of ipatasertib in combination with paclitaxel, followed by atezolizumab in an initial 28-day (1 cycle) period. Ipatasertib will be administered orally daily on Days 1-21, with paclitaxel administered by IV infusion on Days 1, 8 and 15. Atezolizumab will be administered by IV infusion on Day 15. In all subsequent treatment cycles, ipatasertib will be administered orally daily on Days 1-21, paclitaxel will be administered by IV infusion on Days 1, 8, and 15 and atezolizumab will be administered by IV infusion on Days 1 and 15. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm C2 (Ipat + Pacl) (2 weeks) + Atezo
arm group type: Experimental
description: Expansion (Cohort 1): Participants will receive a 2-week lead in of ipatasertib in combination with paclitaxel, followed by atezolizumab in an initial 28-day (1 cycle) period. Ipatasertib will be administered orally daily on Days 1-21, with paclitaxel administered by IV infusion on Days 1, 8 and 15. Atezolizumab will be administered by IV infusion on Day 15. In all subsequent treatment cycles, ipatasertib will be administered orally daily on Days 1-21, paclitaxel will be administered by IV infusion on Days 1, 8, and 15 and atezolizumab will be administered by IV infusion on Days 1 and 15. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm D1: (Atezo + Pacl) (2 weeks) + Ipat
arm group type: Experimental
description: Safety Run-In (Cohort 1): Participants will receive a 2-week lead in of atezolizumab in combination with paclitaxel, followed by ipatasertib in an initial 28-day (1 cycle) period. Atezolizumab will be administered via IV infusion on Days 1 and 15, with paclitaxel administered by IV infusion on Days 1, 8 and 15. Ipatasertib will be administered orally daily on Days 15-21. In all subsequent treatment cycles, ipatasertib will be administered orally daily on Days 1-21, paclitaxel will be administered by IV infusion on Days 1, 8, and 15 and atezolizumab will be administered by IV infusion on Days 1 and 15. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm D2: (Atezo + Pacl) (2 weeks) + Ipat
arm group type: Experimental
description: Expansion (Cohort 1): Participants will receive a 2-week lead in of atezolizumab in combination with paclitaxel, followed by ipatasertib in an initial 28-day (1 cycle) period. Atezolizumab will be administered via IV infusion on Days 1 and 15, with paclitaxel administered by IV infusion on Days 1, 8 and 15. Ipatasertib will be administered orally daily on Days 15-21. In all subsequent treatment cycles, ipatasertib will be administered orally daily on Days 1-21, paclitaxel will be administered by IV infusion on Days 1, 8, and 15 and atezolizumab will be administered by IV infusion on Days 1 and 15. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm E: Ipat + Atezo
arm group type: Experimental
description: Participants (Cohort 2) will receive Ipatasertib orally daily on Days 1-28 of Cycle 1 (35-day cycle) and on Days 1-21 of subsequent cycles (28-day cycles). Atezolizumab will be administered by IV infusion on Days 8 and 22 of Cycle 1 and on Days 1 and 15 of subsequent cycles. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
arm group label: Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group type: Experimental
description: Safety Run-In (Cohort 3): Participants will receive in Cycles 1 and 2 (28 day cycles), Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15 and AC (Doxorubicin and Cyclophosphamide) via IV infusion on Days 1 and 15. In Cycles 3-5, participants will receive Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15, with Paclitaxel administered by IV infusion on Days 1, 8, 15 and 22. All participants in this cohort will continue to be treated for five cycles (28-day cycles; 20 weeks) or until disease progression or unacceptable toxicity, whichever occurs first.
arm group label: Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group type: Experimental
description: Expansion (Cohort 3): Participants will receive in Cycles 1 and 2 (28 day cycles), Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15 and AC (Doxorubicin and Cyclophosphamide) via IV infusion on Days 1 and 15. In Cycles 3-5, participants will receive Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15, with Paclitaxel administered by IV infusion on Days 1, 8, 15 and 22. All participants in this cohort will continue to be treated for five cycles (28-day cycles; 20 weeks) or until disease progression or unacceptable toxicity, whichever occurs first.
arm group label: Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group type: Experimental
description: Safety Run-In (Cohort 3): Participants will receive in Cycles 1 and 2 (28 day cycles), Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15 and AC (Doxorubicin and Cyclophosphamide) via IV infusion on Days 1 and 15. In Cycles 3-5, participants will receive Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15, with Paclitaxel administered by IV infusion on Days 1, 8, 15 and 22. All participants in this cohort will continue to be treated for five cycles (28-day cycles; 20 weeks) or until disease progression or unacceptable toxicity, whichever occurs first.
arm group label: Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group type: Experimental
description: Expansion (Cohort 3): Participants will receive in Cycles 1 and 2 (28 day cycles), Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15 and AC (Doxorubicin and Cyclophosphamide) via IV infusion on Days 1 and 15. In Cycles 3-5, participants will receive Ipatasertib orally daily on Days 1-21, Atezolizumab via IV infusion on Days 1 and 15, with Paclitaxel administered by IV infusion on Days 1, 8, 15 and 22. All participants in this cohort will continue to be treated for five cycles (28-day cycles; 20 weeks) or until disease progression or unacceptable toxicity, whichever occurs first.
arm group label: Arm H: Ipat + Atezo + Pacl
arm group type: Experimental
description: Participants (Cohort 4) will receive ipatasertib orally daily on Days 1-21 of each 28 day cycle, and atezolizumab will be administered by intravenous (IV) infusion on Days 1 and 15 of each 28 day cycle. Paclitaxel will be administered by IV infusion on Days 1, 8, and 15 of each 28 day cycle. All participants in this cohort will continue to be treated until loss of clinical benefit, unacceptable toxicity, or withdrawal of consent.
intervention type: Drug
intervention name: Ipatasertib
description: Ipatasertib will be administered at a dose of 400 milligrams (mg) orally daily on Days 1-21 of each 28 day cycle for all arms except for arms F1/F2 where it will be administered at a dose of 300 milligrams (mg) orally daily for the first two cycles and 400 mg for the remaining three cycles.
arm group label: Arm A1: Ipat + Atezo + Pacl
arm group label: Arm A2: Ipat + Atezo + Pacl
arm group label: Arm A3: Ipat + Atezo + Pacl
arm group label: Arm B1: Ipat + Atezo + Nab-Pacl
arm group label: Arm B2: Ipat + Atezo + Nab-Pacl
arm group label: Arm C1: (Ipat + Pacl) (2 weeks) + Atezo
arm group label: Arm C2 (Ipat + Pacl) (2 weeks) + Atezo
arm group label: Arm D1: (Atezo + Pacl) (2 weeks) + Ipat
arm group label: Arm D2: (Atezo + Pacl) (2 weeks) + Ipat
arm group label: Arm E: Ipat + Atezo
arm group label: Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm H: Ipat + Atezo + Pacl
intervention type: Drug
intervention name: Paclitaxel
description: Paclitaxel will be administered at a dose of 80 milligrams per square meter (mg/m^2) as IV infusion on Days 1, 8, and 15 of each 28 day cycle for all arms, with the exceptions of Arms F1, F2, G1 and G2, where it will be also administered on Day 22 as well, of each 28 day cycle.
arm group label: Arm A1: Ipat + Atezo + Pacl
arm group label: Arm A2: Ipat + Atezo + Pacl
arm group label: Arm A3: Ipat + Atezo + Pacl
arm group label: Arm C1: (Ipat + Pacl) (2 weeks) + Atezo
arm group label: Arm C2 (Ipat + Pacl) (2 weeks) + Atezo
arm group label: Arm D1: (Atezo + Pacl) (2 weeks) + Ipat
arm group label: Arm D2: (Atezo + Pacl) (2 weeks) + Ipat
arm group label: Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm H: Ipat + Atezo + Pacl
intervention type: Drug
intervention name: Atezolizumab
description: Atezolizumab will be administered by IV infusion at a fixed dose of 840 mg on Days 1 and 15 of each 28 day cycle for all arms, although in Arms C1/C2, it will be administered on Day 15 of Cycle 1 followed by Days 1 and 15 in subsequent cycles.
arm group label: Arm A1: Ipat + Atezo + Pacl
arm group label: Arm A2: Ipat + Atezo + Pacl
arm group label: Arm A3: Ipat + Atezo + Pacl
arm group label: Arm B1: Ipat + Atezo + Nab-Pacl
arm group label: Arm B2: Ipat + Atezo + Nab-Pacl
arm group label: Arm C1: (Ipat + Pacl) (2 weeks) + Atezo
arm group label: Arm C2 (Ipat + Pacl) (2 weeks) + Atezo
arm group label: Arm D1: (Atezo + Pacl) (2 weeks) + Ipat
arm group label: Arm D2: (Atezo + Pacl) (2 weeks) + Ipat
arm group label: Arm E: Ipat + Atezo
arm group label: Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm H: Ipat + Atezo + Pacl
intervention type: Drug
intervention name: Nab-Paclitaxel
description: Nab-paclitaxel will be administered by IV infusion at a dose of 100 mg/m^2 on Days 1, 8, and 15 of each 28 day cycle.
arm group label: Arm B1: Ipat + Atezo + Nab-Pacl
arm group label: Arm B2: Ipat + Atezo + Nab-Pacl
intervention type: Drug
intervention name: AC
description: AC (Doxorubicin and Cyclophosphamide) will be administered by IV infusion at 60 mg/m^2 and 600 mg/m^2 respectively on Days 1 and 15 of Cycles 1 and 2 for Arms F1, F2, G1 and G2.
arm group label: Arm F1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm F2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm G1: Ipat + Atezol + AC / Ipat + Atezo + Pacl
arm group label: Arm G2: Ipat + Atezol + AC / Ipat + Atezo + Pacl
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Clinical Trials
role: Study Director
affiliation: Hoffmann-La Roche
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country: Australia
country: France
country: Spain
country: United Kingdom
country: United States
responsible party type: Sponsor
mesh term: Breast Neoplasms
mesh term: Triple Negative Breast Neoplasms
mesh term: Paclitaxel
mesh term: Albumin-Bound Paclitaxel
mesh term: Atezolizumab
mesh term: Ipatasertib
submitted: March 15, 2023