<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03772652</url>
  </required_header>
  <id_info>
    <org_study_id>HUM00148346</org_study_id>
    <nct_id>NCT03772652</nct_id>
  </id_info>
  <brief_title>Long-term Surgical Therapeutic Outcomes of Peri-Implantitis</brief_title>
  <official_title>Long-term Surgical Therapeutic Outcomes of Peri-Implantitis</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Michigan</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>University of Michigan</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This study focuses on evaluating the success of different treatment methods for&#xD;
      peri-implantitis (gum disease around implants) and to understand the factors that might&#xD;
      affect the success of the treatment provided.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Qualifying patients will be asked to participate in clinical measurements to compare the&#xD;
      long-term success of their treatments.&#xD;
&#xD;
      The aims of the current study are to 1) assess the long-term outcome of the surgical&#xD;
      treatment of peri-implantitis and to 2) evaluate the success of the different treatment&#xD;
      modalities of peri-implantitis.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Terminated</overall_status>
  <why_stopped>
    COVID-19 pandemic&#xD;
  </why_stopped>
  <start_date type="Actual">December 4, 2018</start_date>
  <completion_date type="Actual">February 13, 2020</completion_date>
  <primary_completion_date type="Actual">February 13, 2020</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Cross-Sectional</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Therapeutic resolution of the peri-implantitis as measured by radiographic bone loss</measure>
    <time_frame>At least five years after the implant was treated for peri-implantitis</time_frame>
    <description>The implant has no further radiographic bone loss when compared to previous radiographs.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Therapeutic resolution of the peri-implantitis as measured by erythema</measure>
    <time_frame>At least five years after the implant was treated for peri-implantitis</time_frame>
    <description>The implant has no current erythema of the peri-implant mucosa.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Therapeutic resolution of the peri-implantitis as measured by probing depths</measure>
    <time_frame>At least five years after the implant was treated for peri-implantitis</time_frame>
    <description>The implant has probing depths less than or equal to 5 millimeters.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Survival rate of the peri-implantitis treated dental implants</measure>
    <time_frame>At least five years after the implant was treated for peri-implantitis</time_frame>
    <description>Survival rate will be determined by the duration of implant survival (functioning, non-symptomatic implant after peri-implantitis treatment).</description>
  </primary_outcome>
  <number_of_groups>1</number_of_groups>
  <enrollment type="Actual">38</enrollment>
  <condition>Peri-Implantitis</condition>
  <arm_group>
    <arm_group_label>Peri-implantitis</arm_group_label>
    <description>Subjects who were diagnosed with peri-implantitis and received treatment at least five years ago at the Graduate Periodontics Clinic at University of Michigan with sufficient baseline data. Soft tissue measurements (observation) of the implant will be completed.</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Observation</intervention_name>
    <description>Soft tissue implant measurements</description>
    <arm_group_label>Peri-implantitis</arm_group_label>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        Subjects who were diagnosed with peri-implantitis and received treatment at least 5 years&#xD;
        ago.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. The patient is at least 18 years of age,&#xD;
&#xD;
          2. was initially diagnosed with peri-implantitis at ≥1 implant (peri-implant probing&#xD;
             depth (PPD) ≥ 6 mm together with bleeding and/or suppuration on probing (BOP/SoP) and&#xD;
             radiologically assessed marginal bone loss ≥ 3 mm),&#xD;
&#xD;
          3. had received treatment for peri-implantitis at least 5 years ago at the Graduate&#xD;
             Clinic of Periodontics at University of Michigan, and&#xD;
&#xD;
          4. documentation from ≥ 5 years of clinical and radiological follow-up is available from&#xD;
             U of M patients records.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Has received or is currently receiving radiotherapy,&#xD;
&#xD;
          2. are currently pregnant, unsure of their pregnancy status, or are lactating (as&#xD;
             reported by the patient),&#xD;
&#xD;
          3. has health condition(s) or takes medication(s) that are known to affect soft tissue or&#xD;
             bone (e.g., Phenytoin)&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
  </eligibility>
  <overall_official>
    <last_name>Hom-Lay Wang, DDS MSD PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Department of Periodontics and Oral Medicine University of Michigan</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>University of Michigan School of Dentistry</name>
      <address>
        <city>Ann Arbor</city>
        <state>Michigan</state>
        <zip>48109</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <reference>
    <citation>Peri-implant mucositis and peri-implantitis: a current understanding of their diagnoses and clinical implications. J Periodontol. 2013 Apr;84(4):436-43. doi: 10.1902/jop.2013.134001. No abstract available.</citation>
    <PMID>23537178</PMID>
  </reference>
  <reference>
    <citation>Lindhe J, Meyle J; Group D of European Workshop on Periodontology. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008 Sep;35(8 Suppl):282-5. doi: 10.1111/j.1600-051X.2008.01283.x.</citation>
    <PMID>18724855</PMID>
  </reference>
  <reference>
    <citation>Lang NP, Berglundh T; Working Group 4 of Seventh European Workshop on Periodontology. Periimplant diseases: where are we now?--Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol. 2011 Mar;38 Suppl 11:178-81. doi: 10.1111/j.1600-051X.2010.01674.x.</citation>
    <PMID>21323713</PMID>
  </reference>
  <reference>
    <citation>Sanz M, Chapple IL; Working Group 4 of the VIII European Workshop on Periodontology. Clinical research on peri-implant diseases: consensus report of Working Group 4. J Clin Periodontol. 2012 Feb;39 Suppl 12:202-6. doi: 10.1111/j.1600-051X.2011.01837.x.</citation>
    <PMID>22533957</PMID>
  </reference>
  <reference>
    <citation>Derks J, Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol. 2015 Apr;42 Suppl 16:S158-71. doi: 10.1111/jcpe.12334.</citation>
    <PMID>25495683</PMID>
  </reference>
  <reference>
    <citation>Mombelli A, Muller N, Cionca N. The epidemiology of peri-implantitis. Clin Oral Implants Res. 2012 Oct;23 Suppl 6:67-76. doi: 10.1111/j.1600-0501.2012.02541.x.</citation>
    <PMID>23062130</PMID>
  </reference>
  <reference>
    <citation>Kotsovilis S, Karoussis IK, Trianti M, Fourmousis I. Therapy of peri-implantitis: a systematic review. J Clin Periodontol. 2008 Jul;35(7):621-9. doi: 10.1111/j.1600-051X.2008.01240.x. Epub 2008 May 11.</citation>
    <PMID>18476998</PMID>
  </reference>
  <reference>
    <citation>Klokkevold PR, Han TJ. How do smoking, diabetes, and periodontitis affect outcomes of implant treatment? Int J Oral Maxillofac Implants. 2007;22 Suppl:173-202. Erratum In: Int J Oral Maxillofac Implants. 2008 Jan-Feb;23(1):56.</citation>
    <PMID>18437796</PMID>
  </reference>
  <reference>
    <citation>Canullo L, Penarrocha M, Monje A, Catena A, Wang HL, Penarrocha D. Association Between Clinical and Microbiologic Cluster Profiles and Peri-implantitis. Int J Oral Maxillofac Implants. 2017 Sep/Oct;32(5):1054-1064. doi: 10.11607/jomi.6043.</citation>
    <PMID>28906504</PMID>
  </reference>
  <reference>
    <citation>Machtei EE. Treatment Alternatives to Negotiate Peri-Implantitis. Adv Med. 2014;2014:487903. doi: 10.1155/2014/487903. Epub 2014 Jun 15.</citation>
    <PMID>26556414</PMID>
  </reference>
  <reference>
    <citation>Renvert S, Polyzois I, Claffey N. Surgical therapy for the control of peri-implantitis. Clin Oral Implants Res. 2012 Oct;23 Suppl 6:84-94. doi: 10.1111/j.1600-0501.2012.02554.x.</citation>
    <PMID>23062132</PMID>
  </reference>
  <reference>
    <citation>Romeo E, Lops D, Chiapasco M, Ghisolfi M, Vogel G. Therapy of peri-implantitis with resective surgery. A 3-year clinical trial on rough screw-shaped oral implants. Part II: radiographic outcome. Clin Oral Implants Res. 2007 Apr;18(2):179-87. doi: 10.1111/j.1600-0501.2006.01318.x.</citation>
    <PMID>17348882</PMID>
  </reference>
  <reference>
    <citation>Wiltfang J, Zernial O, Behrens E, Schlegel A, Warnke PH, Becker ST. Regenerative treatment of peri-implantitis bone defects with a combination of autologous bone and a demineralized xenogenic bone graft: a series of 36 defects. Clin Implant Dent Relat Res. 2012 Jun;14(3):421-7. doi: 10.1111/j.1708-8208.2009.00264.x. Epub 2010 Feb 3.</citation>
    <PMID>20132246</PMID>
  </reference>
  <reference>
    <citation>Khoury F, Buchmann R. Surgical therapy of peri-implant disease: a 3-year follow-up study of cases treated with 3 different techniques of bone regeneration. J Periodontol. 2001 Nov;72(11):1498-508. doi: 10.1902/jop.2001.72.11.1498.</citation>
    <PMID>11759861</PMID>
  </reference>
  <reference>
    <citation>Li X, Wang X, Zhao T, Gao B, Miao Y, Zhang D, Dong Y. Guided bone regeneration using chitosan-collagen membranes in dog dehiscence-type defect model. J Oral Maxillofac Surg. 2014 Feb;72(2):304.e1-14. doi: 10.1016/j.joms.2013.09.042. Epub 2013 Oct 9.</citation>
    <PMID>24438600</PMID>
  </reference>
  <reference>
    <citation>Schou S, Holmstrup P, Skovgaard LT, Stoltze K, Hjorting-Hansen E, Gundersen HJ. Autogenous bone graft and ePTFE membrane in the treatment of peri-implantitis. II. Stereologic and histologic observations in cynomolgus monkeys. Clin Oral Implants Res. 2003 Aug;14(4):404-11. doi: 10.1034/j.1600-0501.2003.120910.x.</citation>
    <PMID>12869002</PMID>
  </reference>
  <reference>
    <citation>Schou S, Holmstrup P, Jorgensen T, Stoltze K, Hjorting-Hansen E, Wenzel A. Autogenous bone graft and ePTFE membrane in the treatment of peri-implantitis. I. Clinical and radiographic observations in cynomolgus monkeys. Clin Oral Implants Res. 2003 Aug;14(4):391-403. doi: 10.1034/j.1600-0501.2003.120909.x.</citation>
    <PMID>12869001</PMID>
  </reference>
  <reference>
    <citation>Javed F, Al-Askar M, Al-Rasheed A, Al-Hezaimi K. Significance of the platelet-derived growth factor in periodontal tissue regeneration. Arch Oral Biol. 2011 Dec;56(12):1476-84. doi: 10.1016/j.archoralbio.2011.06.020. Epub 2011 Jul 20.</citation>
    <PMID>21774915</PMID>
  </reference>
  <reference>
    <citation>Jung RE, Glauser R, Scharer P, Hammerle CH, Sailer HF, Weber FE. Effect of rhBMP-2 on guided bone regeneration in humans. Clin Oral Implants Res. 2003 Oct;14(5):556-68. doi: 10.1034/j.1600-0501.2003.00921.x.</citation>
    <PMID>12969359</PMID>
  </reference>
  <reference>
    <citation>Froum SJ, Rosen PS. A proposed classification for peri-implantitis. Int J Periodontics Restorative Dent. 2012 Oct;32(5):533-40.</citation>
    <PMID>22754901</PMID>
  </reference>
  <reference>
    <citation>Faggion CM Jr, Listl S, Tu YK. Assessment of endpoints in studies on peri-implantitis treatment--a systematic review. J Dent. 2010 Jun;38(6):443-50. doi: 10.1016/j.jdent.2010.03.003. Epub 2010 Mar 11.</citation>
    <PMID>20226832</PMID>
  </reference>
  <reference>
    <citation>Roos-Jansaker AM, Lindahl C, Persson GR, Renvert S. Long-term stability of surgical bone regenerative procedures of peri-implantitis lesions in a prospective case-control study over 3 years. J Clin Periodontol. 2011 Jun;38(6):590-7. doi: 10.1111/j.1600-051X.2011.01729.x. Epub 2011 Apr 13.</citation>
    <PMID>21488935</PMID>
  </reference>
  <reference>
    <citation>Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, Chen S, Cochran D, Derks J, Figuero E, Hammerle CHF, Heitz-Mayfield LJA, Huynh-Ba G, Iacono V, Koo KT, Lambert F, McCauley L, Quirynen M, Renvert S, Salvi GE, Schwarz F, Tarnow D, Tomasi C, Wang HL, Zitzmann N. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018 Jun;89 Suppl 1:S313-S318. doi: 10.1002/JPER.17-0739.</citation>
    <PMID>29926955</PMID>
  </reference>
  <reference>
    <citation>Schwarz F, Herten M, Sager M, Bieling K, Sculean A, Becker J. Comparison of naturally occurring and ligature-induced peri-implantitis bone defects in humans and dogs. Clin Oral Implants Res. 2007 Apr;18(2):161-70. doi: 10.1111/j.1600-0501.2006.01320.x. Erratum In: Clin Oral Implants Res. 2007 Jun;18(3):397.</citation>
    <PMID>17348880</PMID>
  </reference>
  <reference>
    <citation>Monje A, Wang HL, Nart J. Association of Preventive Maintenance Therapy Compliance and Peri-Implant Diseases: A Cross-Sectional Study. J Periodontol. 2017 Oct;88(10):1030-1041. doi: 10.1902/jop.2017.170135. Epub 2017 May 26.</citation>
    <PMID>28548886</PMID>
  </reference>
  <verification_date>December 2021</verification_date>
  <study_first_submitted>December 5, 2018</study_first_submitted>
  <study_first_submitted_qc>December 10, 2018</study_first_submitted_qc>
  <study_first_posted type="Actual">December 11, 2018</study_first_posted>
  <last_update_submitted>December 13, 2021</last_update_submitted>
  <last_update_submitted_qc>December 13, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">January 5, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>University of Michigan</investigator_affiliation>
    <investigator_full_name>Hom-Lay Wang, DDS, MSD, Ph D</investigator_full_name>
    <investigator_title>Collegiate Professor of Periodontics and Professor of Dentistry</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Peri-Implantitis</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03772652
org study id: HUM00148346
nct id: NCT03772652
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
This study focuses on evaluating the success of different treatment methods for
      peri-implantitis (gum disease around implants) and to understand the factors that might
      affect the success of the treatment provided.
Qualifying patients will be asked to participate in clinical measurements to compare the
      long-term success of their treatments.

      The aims of the current study are to 1) assess the long-term outcome of the surgical
      treatment of peri-implantitis and to 2) evaluate the success of the different treatment
      modalities of peri-implantitis.
observational model: Cohort
time perspective: Cross-Sectional
measure: Therapeutic resolution of the peri-implantitis as measured by radiographic bone loss
time frame: At least five years after the implant was treated for peri-implantitis
description: The implant has no further radiographic bone loss when compared to previous radiographs.
measure: Therapeutic resolution of the peri-implantitis as measured by erythema
time frame: At least five years after the implant was treated for peri-implantitis
description: The implant has no current erythema of the peri-implant mucosa.
measure: Therapeutic resolution of the peri-implantitis as measured by probing depths
time frame: At least five years after the implant was treated for peri-implantitis
description: The implant has probing depths less than or equal to 5 millimeters.
measure: Survival rate of the peri-implantitis treated dental implants
time frame: At least five years after the implant was treated for peri-implantitis
description: Survival rate will be determined by the duration of implant survival (functioning, non-symptomatic implant after peri-implantitis treatment).
arm group label: Peri-implantitis
description: Subjects who were diagnosed with peri-implantitis and received treatment at least five years ago at the Graduate Periodontics Clinic at University of Michigan with sufficient baseline data. Soft tissue measurements (observation) of the implant will be completed.
intervention type: Other
intervention name: Observation
description: Soft tissue implant measurements
arm group label: Peri-implantitis
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
last name: Hom-Lay Wang, DDS MSD PhD
role: Principal Investigator
affiliation: Department of Periodontics and Oral Medicine University of Michigan
facility: 
country: United States
citation: Peri-implant mucositis and peri-implantitis: a current understanding of their diagnoses and clinical implications. J Periodontol. 2013 Apr;84(4):436-43. doi: 10.1902/jop.2013.134001. No abstract available.
PMID: 23537178
citation: Lindhe J, Meyle J; Group D of European Workshop on Periodontology. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008 Sep;35(8 Suppl):282-5. doi: 10.1111/j.1600-051X.2008.01283.x.
PMID: 18724855
citation: Lang NP, Berglundh T; Working Group 4 of Seventh European Workshop on Periodontology. Periimplant diseases: where are we now?--Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol. 2011 Mar;38 Suppl 11:178-81. doi: 10.1111/j.1600-051X.2010.01674.x.
PMID: 21323713
citation: Sanz M, Chapple IL; Working Group 4 of the VIII European Workshop on Periodontology. Clinical research on peri-implant diseases: consensus report of Working Group 4. J Clin Periodontol. 2012 Feb;39 Suppl 12:202-6. doi: 10.1111/j.1600-051X.2011.01837.x.
PMID: 22533957
citation: Derks J, Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol. 2015 Apr;42 Suppl 16:S158-71. doi: 10.1111/jcpe.12334.
PMID: 25495683
citation: Mombelli A, Muller N, Cionca N. The epidemiology of peri-implantitis. Clin Oral Implants Res. 2012 Oct;23 Suppl 6:67-76. doi: 10.1111/j.1600-0501.2012.02541.x.
PMID: 23062130
citation: Kotsovilis S, Karoussis IK, Trianti M, Fourmousis I. Therapy of peri-implantitis: a systematic review. J Clin Periodontol. 2008 Jul;35(7):621-9. doi: 10.1111/j.1600-051X.2008.01240.x. Epub 2008 May 11.
PMID: 18476998
citation: Klokkevold PR, Han TJ. How do smoking, diabetes, and periodontitis affect outcomes of implant treatment? Int J Oral Maxillofac Implants. 2007;22 Suppl:173-202. Erratum In: Int J Oral Maxillofac Implants. 2008 Jan-Feb;23(1):56.
PMID: 18437796
citation: Canullo L, Penarrocha M, Monje A, Catena A, Wang HL, Penarrocha D. Association Between Clinical and Microbiologic Cluster Profiles and Peri-implantitis. Int J Oral Maxillofac Implants. 2017 Sep/Oct;32(5):1054-1064. doi: 10.11607/jomi.6043.
PMID: 28906504
citation: Machtei EE. Treatment Alternatives to Negotiate Peri-Implantitis. Adv Med. 2014;2014:487903. doi: 10.1155/2014/487903. Epub 2014 Jun 15.
PMID: 26556414
citation: Renvert S, Polyzois I, Claffey N. Surgical therapy for the control of peri-implantitis. Clin Oral Implants Res. 2012 Oct;23 Suppl 6:84-94. doi: 10.1111/j.1600-0501.2012.02554.x.
PMID: 23062132
citation: Romeo E, Lops D, Chiapasco M, Ghisolfi M, Vogel G. Therapy of peri-implantitis with resective surgery. A 3-year clinical trial on rough screw-shaped oral implants. Part II: radiographic outcome. Clin Oral Implants Res. 2007 Apr;18(2):179-87. doi: 10.1111/j.1600-0501.2006.01318.x.
PMID: 17348882
citation: Wiltfang J, Zernial O, Behrens E, Schlegel A, Warnke PH, Becker ST. Regenerative treatment of peri-implantitis bone defects with a combination of autologous bone and a demineralized xenogenic bone graft: a series of 36 defects. Clin Implant Dent Relat Res. 2012 Jun;14(3):421-7. doi: 10.1111/j.1708-8208.2009.00264.x. Epub 2010 Feb 3.
PMID: 20132246
citation: Khoury F, Buchmann R. Surgical therapy of peri-implant disease: a 3-year follow-up study of cases treated with 3 different techniques of bone regeneration. J Periodontol. 2001 Nov;72(11):1498-508. doi: 10.1902/jop.2001.72.11.1498.
PMID: 11759861
citation: Li X, Wang X, Zhao T, Gao B, Miao Y, Zhang D, Dong Y. Guided bone regeneration using chitosan-collagen membranes in dog dehiscence-type defect model. J Oral Maxillofac Surg. 2014 Feb;72(2):304.e1-14. doi: 10.1016/j.joms.2013.09.042. Epub 2013 Oct 9.
PMID: 24438600
citation: Schou S, Holmstrup P, Skovgaard LT, Stoltze K, Hjorting-Hansen E, Gundersen HJ. Autogenous bone graft and ePTFE membrane in the treatment of peri-implantitis. II. Stereologic and histologic observations in cynomolgus monkeys. Clin Oral Implants Res. 2003 Aug;14(4):404-11. doi: 10.1034/j.1600-0501.2003.120910.x.
PMID: 12869002
citation: Schou S, Holmstrup P, Jorgensen T, Stoltze K, Hjorting-Hansen E, Wenzel A. Autogenous bone graft and ePTFE membrane in the treatment of peri-implantitis. I. Clinical and radiographic observations in cynomolgus monkeys. Clin Oral Implants Res. 2003 Aug;14(4):391-403. doi: 10.1034/j.1600-0501.2003.120909.x.
PMID: 12869001
citation: Javed F, Al-Askar M, Al-Rasheed A, Al-Hezaimi K. Significance of the platelet-derived growth factor in periodontal tissue regeneration. Arch Oral Biol. 2011 Dec;56(12):1476-84. doi: 10.1016/j.archoralbio.2011.06.020. Epub 2011 Jul 20.
PMID: 21774915
citation: Jung RE, Glauser R, Scharer P, Hammerle CH, Sailer HF, Weber FE. Effect of rhBMP-2 on guided bone regeneration in humans. Clin Oral Implants Res. 2003 Oct;14(5):556-68. doi: 10.1034/j.1600-0501.2003.00921.x.
PMID: 12969359
citation: Froum SJ, Rosen PS. A proposed classification for peri-implantitis. Int J Periodontics Restorative Dent. 2012 Oct;32(5):533-40.
PMID: 22754901
citation: Faggion CM Jr, Listl S, Tu YK. Assessment of endpoints in studies on peri-implantitis treatment--a systematic review. J Dent. 2010 Jun;38(6):443-50. doi: 10.1016/j.jdent.2010.03.003. Epub 2010 Mar 11.
PMID: 20226832
citation: Roos-Jansaker AM, Lindahl C, Persson GR, Renvert S. Long-term stability of surgical bone regenerative procedures of peri-implantitis lesions in a prospective case-control study over 3 years. J Clin Periodontol. 2011 Jun;38(6):590-7. doi: 10.1111/j.1600-051X.2011.01729.x. Epub 2011 Apr 13.
PMID: 21488935
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PMID: 29926955
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PMID: 17348880
citation: Monje A, Wang HL, Nart J. Association of Preventive Maintenance Therapy Compliance and Peri-Implant Diseases: A Cross-Sectional Study. J Periodontol. 2017 Oct;88(10):1030-1041. doi: 10.1902/jop.2017.170135. Epub 2017 May 26.
PMID: 28548886
responsible party type: Principal Investigator
investigator affiliation: University of Michigan
investigator full name: Hom-Lay Wang, DDS, MSD, Ph D
investigator title: Collegiate Professor of Periodontics and Professor of Dentistry
mesh term: Peri-Implantitis
sharing ipd: Undecided