<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03799237</url>
  </required_header>
  <id_info>
    <org_study_id>GOSNS1-1</org_study_id>
    <secondary_id>MO013-2017</secondary_id>
    <nct_id>NCT03799237</nct_id>
  </id_info>
  <brief_title>Combating Dengue With Innovative, Paradigm-shift-Strategies: Early Dengue Surveillance in Adult Aedes Mosquitoes</brief_title>
  <official_title>Cluster Randomized Controlled Trial: Efficacy of Gravid Oviposition Sticky Trap (GOS) and Dengue NS1 Antigen Rapid Diagnostic Test for Early Surveillance of Dengue Among Adult Aedes Mosquitoes to Reduce Dengue Outbreaks in PJU10, Damansara Damai, Selangor, Malaysia</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Jonathan Liew Wee Kent</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Petaling Jaya City Council, Malaysia</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Selangor State Health Department, Malaysia</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Malaya</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      During dengue outbreaks, the Ministry of Health Malaysia employs various methods to control&#xD;
      the spread of disease, including killing the larvae of Aedes mosquitoes, fogging, together&#xD;
      with educating and disseminating information about the dengue outbreak, to the community.&#xD;
      However, this is too late. Research has shown that when an outbreak has occurred, the viral&#xD;
      infection has already spread among the community. Therefore, this current trial aims to&#xD;
      educate the public (via questionnaire survey and interactions with the residential&#xD;
      managements, mainly), detect dengue-infected mosquitoes, inform the communities of the&#xD;
      presence of dengue-infected mosquitoes, followed by approaching and educating them to take&#xD;
      precautionary measures before the outbreak happens. Trapping (using gravid oviposition sticky&#xD;
      (GOS) traps) and detecting dengue virus non-structural 1 (NS1) antigen (using dengue NS1 kit)&#xD;
      in the Aedes mosquitoes will be a more reliable way to alert the community before a potential&#xD;
      dengue outbreak in their housing area. The community will receive information of presence of&#xD;
      infected mosquitoes and probable dengue infections before dengue cases are reported. This&#xD;
      will be an ideal time for clean-ups and for search and destroy activities. With this shift in&#xD;
      approach and the use of newer techniques, it is hoped that deaths and epidemics due to dengue&#xD;
      will be reduced.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      This cluster randomised controlled trial will be conducted to provide evidence on the&#xD;
      efficacy of an integrated active vector surveillance and preventive strategy in the&#xD;
      community. It aims to demonstrate effectiveness of a new proactive paradigm in reducing&#xD;
      dengue epidemics. The main hypotheses are 1) This new paradigm (GOS trap and dengue NS1 kit&#xD;
      for detection of dengue in Aedes) will reduce dengue epidemics compared to the usual current&#xD;
      vector surveillance/control carried out by the Ministry of Health. 2) Community will be more&#xD;
      receptive to this new surveillance activity as they will receive information of dengue&#xD;
      transmissions before dengue cases are reported.&#xD;
&#xD;
      The study sites at PJU10, Damansara Damai, Petaling Jaya, Selangor, Malaysia are&#xD;
&#xD;
        1. Intervention arm: Harmoni Apartment, Impian Apartment, Park Avenue Condominium, and&#xD;
           Suria Shop Apartment&#xD;
&#xD;
        2. Control arm: Permai Apartment, Lestari Apartment, Indah Apartment, and Vista Shop&#xD;
           Apartment&#xD;
&#xD;
      Activities to be carried out include:&#xD;
&#xD;
      A. Questionnaire survey and blood taking for dengue seroprevalence among residents from both&#xD;
      arms When people in the community are gathered at an identified, suitable area, the&#xD;
      Knowledge, Attitude and Practice (KAP) questionnaires will be distributed for them to answer.&#xD;
      After the questionnaire survey, about 3 ml of venous blood would be taken by trained&#xD;
      personnel for dengue IgG and IgM serology.&#xD;
&#xD;
      B. Placement of the GOS mosquito trap in the intervention arm The GOS mosquito traps will be&#xD;
      placed in the intervention arm and serviced weekly. The trapped Aedes mosquitoes would be&#xD;
      checked for dengue virus via dengue NS1 rapid diagnostic test kit.&#xD;
&#xD;
      The GOS mosquito traps will also be placed randomly in the control arm once per month for&#xD;
      entomological survey.&#xD;
&#xD;
      C. If a dengue-positive mosquito is found, flyers and banners will be distributed and hung to&#xD;
      inform the residents of the presence of dengue transmission in the apartment block/apartment.&#xD;
      Alternatively, the residents may also be approached house-to-house or an educational booth&#xD;
      set up at strategic locations in the apartment to warn and educate the residents.&#xD;
&#xD;
      D. The KAP questionnaire survey will be carried out again 3 months before the completion of&#xD;
      the trial in the intervention arm to gauge the communities' perception of this intervention.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">October 1, 2018</start_date>
  <completion_date type="Anticipated">April 30, 2020</completion_date>
  <primary_completion_date type="Anticipated">March 31, 2020</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>Cluster Randomized Controlled Trial</intervention_model_description>
    <primary_purpose>Prevention</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Change in number of weekly notified dengue cases in intervention arm</measure>
    <time_frame>Assess weekly, through study completion, 1 and a half years</time_frame>
    <description>The number of notified dengue cases in the study sites will be obtained from the District Health Office</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Change in the duration of dengue outbreaks in intervention arm</measure>
    <time_frame>Through study completion, an average of 1 and a half years</time_frame>
    <description>The duration of dengue outbreaks in the study sites will be obtained from the District Health Office.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Change in adult Aedes density in the intervention arm</measure>
    <time_frame>Assess weekly, through study completion, within 1 and half years.</time_frame>
    <description>Based on the weekly trap index</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in level of dengue Knowledge, Attitude and Practice in the intervention arm</measure>
    <time_frame>6 months after recruitment for pre-trial questionnaire survey. 3 months after recruitment for post-trial questionnaire survey, through study completion, 1 and a half years</time_frame>
    <description>The mean of the percentage score of the population for each domain (knowledge &amp; attitude/practises) will be determined for the pre- and post-test. Then, paired t-test will be performed to determine the presence of significant changes in both means (An increase in score percentage indicate a better outcome). Additionally, an individual percentage score of 80% and above indicates indicates good knowledge/attitude/practice.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">7979</enrollment>
  <condition>Dengue</condition>
  <arm_group>
    <arm_group_label>GOS trap and dengue NS1 antigen kit</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Gravid Oviposition Sticky (GOS) traps will be placed to trap adult Aedes mosquitoes and changed weekly. NS1 will be used to detect dengue in trapped Aedes mosquitoes. When dengue NS1 positive mosquitoes are found, community will be alerted via flyers, banners and other means. Routine Aedes/dengue control and surveillance will be carried out as usual as per the current Ministry of Health guidelines.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Control</arm_group_label>
    <arm_group_type>No Intervention</arm_group_type>
    <description>The GOS traps will be placed randomly in the control arm once per month for entomological survey. Routine Aedes control and surveillance will be carried out as per the current Ministry of Health guidelines. Dengue control measure will be initiated by the health authorities when human cases are reported from this arm.</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>GOS trap and dengue NS1 antigen kit</intervention_name>
    <description>The GOS trap lure and sticky surfaces to trap gravid Aedes mosquitoes. Three GOS traps will be placed on every 3 floors of the residential blocks. The traps will be changed weekly. Trapped Aedes mosquitoes will be identified to species. The mosquitoes will then be dissected, to remove the abdomen from the thorax. Five to seven abdomens of the same mosquito species will be pooled and tested for dengue NS1 antigen using the SD Biosensor Standard Q dengue NS1 antigen test kit. If the pool is tested positive for dengue NS1, the head and thorax of the respective abdomens will be subjected to the same procedure for dengue NS1 antigen test, individually. This may allow us to identify a focus where there could be dengue-infected individuals. Flyers/Posters will be disseminated besides, house-to-house approach to inform the residents of the findings and apartment blocks where these mosquitoes were found. The apartment management will also make use of social media disseminate this information.</description>
    <arm_group_label>GOS trap and dengue NS1 antigen kit</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Age 18 years and above, including pregnant women and healthy individuals&#xD;
&#xD;
          -  Reside in the study sites&#xD;
&#xD;
          -  Work at the study sites for at least 40 hours per week&#xD;
&#xD;
          -  Able to give consent&#xD;
&#xD;
          -  Willing to participate in blood taking&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Age below 18 years&#xD;
&#xD;
          -  Unable to give consent&#xD;
&#xD;
          -  Not willing to undergo venepuncture or finger-prick&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Jonathan WK Liew, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Malaya</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Indra Vythilingam, PhD</last_name>
    <role>Study Director</role>
    <affiliation>University of Malaya</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Jonathan WK Liew, PhD</last_name>
    <phone>+60178858375</phone>
    <email>jonathanliew@um.edu.my</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Sivaneswari Selvarajoo, BSc</last_name>
    <phone>+60108968645</phone>
    <email>sivaneswariselvarajoo@gmail.com</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Petaling Jaya City Council</name>
      <address>
        <city>Petaling Jaya</city>
        <state>Selangor</state>
        <country>Malaysia</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Poo Soon Ong, Master</last_name>
    </contact>
  </location>
  <location_countries>
    <country>Malaysia</country>
  </location_countries>
  <reference>
    <citation>Lau SM, Chua TH, Sulaiman WY, Joanne S, Lim YA, Sekaran SD, Chinna K, Venugopalan B, Vythilingam I. A new paradigm for Aedes spp. surveillance using gravid ovipositing sticky trap and NS1 antigen test kit. Parasit Vectors. 2017 Mar 21;10(1):151. doi: 10.1186/s13071-017-2091-y.</citation>
    <PMID>28327173</PMID>
  </reference>
  <reference>
    <citation>Klungthong C, Manasatienkij W, Phonpakobsin T, Chinnawirotpisan P, Rodpradit P, Hussem K, Thaisomboonsuk B, Ong-ajchaowlerd P, Nisalak A, Kalayanarooj S, Buddhari D, Gibbons RV, Jarman RG, Yoon IK, Fernandez S. Monitoring and improving the sensitivity of dengue nested RT-PCR used in longitudinal surveillance in Thailand. J Clin Virol. 2015 Feb;63:25-31. doi: 10.1016/j.jcv.2014.12.009. Epub 2014 Dec 12.</citation>
    <PMID>25600599</PMID>
  </reference>
  <reference>
    <citation>Roslan MA, Ngui R, Vythilingam I, Sulaiman WYW. Evaluation of sticky traps for adult Aedes mosquitoes in Malaysia: a potential monitoring and surveillance tool for the efficacy of control strategies. J Vector Ecol. 2017 Dec;42(2):298-307. doi: 10.1111/jvec.12270.</citation>
    <PMID>29125255</PMID>
  </reference>
  <reference>
    <citation>Chadee DD, Ritchie SA. Efficacy of sticky and standard ovitraps for Aedes aegypti in Trinidad, West Indies. J Vector Ecol. 2010 Dec;35(2):395-400. doi: 10.1111/j.1948-7134.2010.00098.x.</citation>
    <PMID>21175947</PMID>
  </reference>
  <reference>
    <citation>Gama RA, Silva EM, Silva IM, Resende MC, Eiras AE. Evaluation of the sticky MosquiTRAP for detecting Aedes (Stegomyia) aegypti (L.) (Diptera: Culicidae) during the dry season in Belo Horizonte, Minas Gerais, Brazil. Neotrop Entomol. 2007 Mar-Apr;36(2):294-302. doi: 10.1590/s1519-566x2007000200018.</citation>
    <PMID>17607465</PMID>
  </reference>
  <reference>
    <citation>Lee C, Vythilingam I, Chong CS, Abdul Razak MA, Tan CH, Liew C, Pok KY, Ng LC. Gravitraps for management of dengue clusters in Singapore. Am J Trop Med Hyg. 2013 May;88(5):888-892. doi: 10.4269/ajtmh.12-0329. Epub 2013 Mar 11.</citation>
    <PMID>23478581</PMID>
  </reference>
  <reference>
    <citation>Lau SM, Vythilingam I, Doss JI, Sekaran SD, Chua TH, Wan Sulaiman WY, Chinna K, Lim YA, Venugopalan B. Surveillance of adult Aedes mosquitoes in Selangor, Malaysia. Trop Med Int Health. 2015 Oct;20(10):1271-80. doi: 10.1111/tmi.12555. Epub 2015 Jul 14.</citation>
    <PMID>26094839</PMID>
  </reference>
  <verification_date>January 2019</verification_date>
  <study_first_submitted>January 2, 2019</study_first_submitted>
  <study_first_submitted_qc>January 8, 2019</study_first_submitted_qc>
  <study_first_posted type="Actual">January 10, 2019</study_first_posted>
  <last_update_submitted>January 8, 2019</last_update_submitted>
  <last_update_submitted_qc>January 8, 2019</last_update_submitted_qc>
  <last_update_posted type="Actual">January 10, 2019</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>University of Malaya</investigator_affiliation>
    <investigator_full_name>Jonathan Liew Wee Kent</investigator_full_name>
    <investigator_title>Postdoctoral Research Fellow</investigator_title>
  </responsible_party>
  <keyword>Dengue</keyword>
  <keyword>Adult Aedes</keyword>
  <keyword>GOS trap</keyword>
  <keyword>Dengue NS1 antigen test</keyword>
  <keyword>Early dengue detection and surveillance</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Dengue</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
    <ipd_description>Medical ethics have been obtained with a statement that these information is confidential. These information will be deleted within 1 year after the study is completed</ipd_description>
  </patient_data>
  <provided_document_section>
    <provided_document>
      <document_type>Informed Consent Form</document_type>
      <document_has_protocol>No</document_has_protocol>
      <document_has_icf>Yes</document_has_icf>
      <document_has_sap>No</document_has_sap>
      <document_date>January 2, 2019</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/37/NCT03799237/ICF_000.pdf</document_url>
    </provided_document>
    <provided_document>
      <document_type>Study Protocol and Statistical Analysis Plan</document_type>
      <document_has_protocol>Yes</document_has_protocol>
      <document_has_icf>No</document_has_icf>
      <document_has_sap>Yes</document_has_sap>
      <document_date>January 4, 2019</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/37/NCT03799237/Prot_SAP_001.pdf</document_url>
    </provided_document>
  </provided_document_section>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03799237
org study id: GOSNS1-1
secondary id: MO013-2017
nct id: NCT03799237
lead sponsor: 
collaborator: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
During dengue outbreaks, the Ministry of Health Malaysia employs various methods to control
      the spread of disease, including killing the larvae of Aedes mosquitoes, fogging, together
      with educating and disseminating information about the dengue outbreak, to the community.
      However, this is too late. Research has shown that when an outbreak has occurred, the viral
      infection has already spread among the community. Therefore, this current trial aims to
      educate the public (via questionnaire survey and interactions with the residential
      managements, mainly), detect dengue-infected mosquitoes, inform the communities of the
      presence of dengue-infected mosquitoes, followed by approaching and educating them to take
      precautionary measures before the outbreak happens. Trapping (using gravid oviposition sticky
      (GOS) traps) and detecting dengue virus non-structural 1 (NS1) antigen (using dengue NS1 kit)
      in the Aedes mosquitoes will be a more reliable way to alert the community before a potential
      dengue outbreak in their housing area. The community will receive information of presence of
      infected mosquitoes and probable dengue infections before dengue cases are reported. This
      will be an ideal time for clean-ups and for search and destroy activities. With this shift in
      approach and the use of newer techniques, it is hoped that deaths and epidemics due to dengue
      will be reduced.
This cluster randomised controlled trial will be conducted to provide evidence on the
      efficacy of an integrated active vector surveillance and preventive strategy in the
      community. It aims to demonstrate effectiveness of a new proactive paradigm in reducing
      dengue epidemics. The main hypotheses are 1) This new paradigm (GOS trap and dengue NS1 kit
      for detection of dengue in Aedes) will reduce dengue epidemics compared to the usual current
      vector surveillance/control carried out by the Ministry of Health. 2) Community will be more
      receptive to this new surveillance activity as they will receive information of dengue
      transmissions before dengue cases are reported.

      The study sites at PJU10, Damansara Damai, Petaling Jaya, Selangor, Malaysia are

        1. Intervention arm: Harmoni Apartment, Impian Apartment, Park Avenue Condominium, and
           Suria Shop Apartment

        2. Control arm: Permai Apartment, Lestari Apartment, Indah Apartment, and Vista Shop
           Apartment

      Activities to be carried out include:

      A. Questionnaire survey and blood taking for dengue seroprevalence among residents from both
      arms When people in the community are gathered at an identified, suitable area, the
      Knowledge, Attitude and Practice (KAP) questionnaires will be distributed for them to answer.
      After the questionnaire survey, about 3 ml of venous blood would be taken by trained
      personnel for dengue IgG and IgM serology.

      B. Placement of the GOS mosquito trap in the intervention arm The GOS mosquito traps will be
      placed in the intervention arm and serviced weekly. The trapped Aedes mosquitoes would be
      checked for dengue virus via dengue NS1 rapid diagnostic test kit.

      The GOS mosquito traps will also be placed randomly in the control arm once per month for
      entomological survey.

      C. If a dengue-positive mosquito is found, flyers and banners will be distributed and hung to
      inform the residents of the presence of dengue transmission in the apartment block/apartment.
      Alternatively, the residents may also be approached house-to-house or an educational booth
      set up at strategic locations in the apartment to warn and educate the residents.

      D. The KAP questionnaire survey will be carried out again 3 months before the completion of
      the trial in the intervention arm to gauge the communities' perception of this intervention.
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: Cluster Randomized Controlled Trial
primary purpose: Prevention
masking: None (Open Label)
measure: Change in number of weekly notified dengue cases in intervention arm
time frame: Assess weekly, through study completion, 1 and a half years
description: The number of notified dengue cases in the study sites will be obtained from the District Health Office
measure: Change in the duration of dengue outbreaks in intervention arm
time frame: Through study completion, an average of 1 and a half years
description: The duration of dengue outbreaks in the study sites will be obtained from the District Health Office.
measure: Change in adult Aedes density in the intervention arm
time frame: Assess weekly, through study completion, within 1 and half years.
description: Based on the weekly trap index
measure: Change in level of dengue Knowledge, Attitude and Practice in the intervention arm
time frame: 6 months after recruitment for pre-trial questionnaire survey. 3 months after recruitment for post-trial questionnaire survey, through study completion, 1 and a half years
description: The mean of the percentage score of the population for each domain (knowledge & attitude/practises) will be determined for the pre- and post-test. Then, paired t-test will be performed to determine the presence of significant changes in both means (An increase in score percentage indicate a better outcome). Additionally, an individual percentage score of 80% and above indicates indicates good knowledge/attitude/practice.
arm group label: GOS trap and dengue NS1 antigen kit
arm group type: Experimental
description: Gravid Oviposition Sticky (GOS) traps will be placed to trap adult Aedes mosquitoes and changed weekly. NS1 will be used to detect dengue in trapped Aedes mosquitoes. When dengue NS1 positive mosquitoes are found, community will be alerted via flyers, banners and other means. Routine Aedes/dengue control and surveillance will be carried out as usual as per the current Ministry of Health guidelines.
arm group label: Control
arm group type: No Intervention
description: The GOS traps will be placed randomly in the control arm once per month for entomological survey. Routine Aedes control and surveillance will be carried out as per the current Ministry of Health guidelines. Dengue control measure will be initiated by the health authorities when human cases are reported from this arm.
intervention type: Other
intervention name: GOS trap and dengue NS1 antigen kit
description: The GOS trap lure and sticky surfaces to trap gravid Aedes mosquitoes. Three GOS traps will be placed on every 3 floors of the residential blocks. The traps will be changed weekly. Trapped Aedes mosquitoes will be identified to species. The mosquitoes will then be dissected, to remove the abdomen from the thorax. Five to seven abdomens of the same mosquito species will be pooled and tested for dengue NS1 antigen using the SD Biosensor Standard Q dengue NS1 antigen test kit. If the pool is tested positive for dengue NS1, the head and thorax of the respective abdomens will be subjected to the same procedure for dengue NS1 antigen test, individually. This may allow us to identify a focus where there could be dengue-infected individuals. Flyers/Posters will be disseminated besides, house-to-house approach to inform the residents of the findings and apartment blocks where these mosquitoes were found. The apartment management will also make use of social media disseminate this information.
arm group label: GOS trap and dengue NS1 antigen kit
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
last name: Jonathan WK Liew, PhD
role: Principal Investigator
affiliation: University of Malaya
last name: Indra Vythilingam, PhD
role: Study Director
affiliation: University of Malaya
last name: Jonathan WK Liew, PhD
phone: +60178858375
email: jonathanliew@um.edu.my
last name: Sivaneswari Selvarajoo, BSc
phone: +60108968645
email: sivaneswariselvarajoo@gmail.com
facility: 
status: Recruiting
contact: 
country: Malaysia
citation: Lau SM, Chua TH, Sulaiman WY, Joanne S, Lim YA, Sekaran SD, Chinna K, Venugopalan B, Vythilingam I. A new paradigm for Aedes spp. surveillance using gravid ovipositing sticky trap and NS1 antigen test kit. Parasit Vectors. 2017 Mar 21;10(1):151. doi: 10.1186/s13071-017-2091-y.
PMID: 28327173
citation: Klungthong C, Manasatienkij W, Phonpakobsin T, Chinnawirotpisan P, Rodpradit P, Hussem K, Thaisomboonsuk B, Ong-ajchaowlerd P, Nisalak A, Kalayanarooj S, Buddhari D, Gibbons RV, Jarman RG, Yoon IK, Fernandez S. Monitoring and improving the sensitivity of dengue nested RT-PCR used in longitudinal surveillance in Thailand. J Clin Virol. 2015 Feb;63:25-31. doi: 10.1016/j.jcv.2014.12.009. Epub 2014 Dec 12.
PMID: 25600599
citation: Roslan MA, Ngui R, Vythilingam I, Sulaiman WYW. Evaluation of sticky traps for adult Aedes mosquitoes in Malaysia: a potential monitoring and surveillance tool for the efficacy of control strategies. J Vector Ecol. 2017 Dec;42(2):298-307. doi: 10.1111/jvec.12270.
PMID: 29125255
citation: Chadee DD, Ritchie SA. Efficacy of sticky and standard ovitraps for Aedes aegypti in Trinidad, West Indies. J Vector Ecol. 2010 Dec;35(2):395-400. doi: 10.1111/j.1948-7134.2010.00098.x.
PMID: 21175947
citation: Gama RA, Silva EM, Silva IM, Resende MC, Eiras AE. Evaluation of the sticky MosquiTRAP for detecting Aedes (Stegomyia) aegypti (L.) (Diptera: Culicidae) during the dry season in Belo Horizonte, Minas Gerais, Brazil. Neotrop Entomol. 2007 Mar-Apr;36(2):294-302. doi: 10.1590/s1519-566x2007000200018.
PMID: 17607465
citation: Lee C, Vythilingam I, Chong CS, Abdul Razak MA, Tan CH, Liew C, Pok KY, Ng LC. Gravitraps for management of dengue clusters in Singapore. Am J Trop Med Hyg. 2013 May;88(5):888-892. doi: 10.4269/ajtmh.12-0329. Epub 2013 Mar 11.
PMID: 23478581
citation: Lau SM, Vythilingam I, Doss JI, Sekaran SD, Chua TH, Wan Sulaiman WY, Chinna K, Lim YA, Venugopalan B. Surveillance of adult Aedes mosquitoes in Selangor, Malaysia. Trop Med Int Health. 2015 Oct;20(10):1271-80. doi: 10.1111/tmi.12555. Epub 2015 Jul 14.
PMID: 26094839
responsible party type: Sponsor-Investigator
investigator affiliation: University of Malaya
investigator full name: Jonathan Liew Wee Kent
investigator title: Postdoctoral Research Fellow
mesh term: Dengue
sharing ipd: No
ipd description: Medical ethics have been obtained with a statement that these information is confidential. These information will be deleted within 1 year after the study is completed
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