<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03231943</url>
  </required_header>
  <id_info>
    <org_study_id>207187</org_study_id>
    <secondary_id>2017-001367-21</secondary_id>
    <nct_id>NCT03231943</nct_id>
  </id_info>
  <brief_title>GSK3640254 First Time in Human (FTIH) Study in Healthy Volunteers</brief_title>
  <official_title>A Double-Blind (Sponsor Unblinded), Randomized, Placebo-Controlled, Single and Repeated Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of GSK3640254 in Healthy Participants</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>ViiV Healthcare</agency>
      <agency_class>Industry</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>GlaxoSmithKline</agency>
      <agency_class>Industry</agency_class>
    </collaborator>
  </sponsors>
  <source>ViiV Healthcare</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Human immuno deficiency virus 1 (HIV-1) infections continues to be a serious health threat&#xD;
      throughout the world and development of medicines with new mechanism of action have an&#xD;
      important role to play. GSK3640254 is a maturation inhibitor (MI) and can be effective in&#xD;
      HIV-1 treatment. This randomized, 2-part, single and repeat increasing dose study will&#xD;
      collect information on safety, tolerability and drug levels in the body of in healthy&#xD;
      subjects for GSK3640254. The information collected in this study will help in further&#xD;
      clinical development of GSK3640254, including a Phase IIA Proof of Concept (PoC) study in&#xD;
      HIV-infected subjects. Approximately 16 healthy subjects will be randomized to receive single&#xD;
      oral dose of GSK3640254 and placebo in Part 1 and approximately 56 healthy subjects will be&#xD;
      randomized to receive repeat oral dose of GSK3640254 or placebo in Part 2. All doses will be&#xD;
      given immediately after a moderate fat meal. Maximum duration of study participation will be&#xD;
      approximately 12 weeks.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">September 19, 2017</start_date>
  <completion_date type="Actual">September 9, 2018</completion_date>
  <primary_completion_date type="Actual">September 9, 2018</primary_completion_date>
  <phase>Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Sequential Assignment</intervention_model>
    <intervention_model_description>This is a dose-escalation study and dose will be escalated based on the safety data of the initial dose.</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Investigator)</masking>
    <masking_description>This will be a double-blind study with subjects and the site-staff blinded and sponsor unblinded.</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Part 1:Number of Participants With Adverse Events (AEs) and Serious AEs (SAEs)</measure>
    <time_frame>Up to Day 15</time_frame>
    <description>An AE is any untoward medical occurrence in a subject, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product. Any untoward event resulting in death, life threatening, requires hospitalization or prolongation of existing hospitalization, results in disability/incapacity, congenital anomaly/birth defect or any other situation according to medical or scientific judgment will be categorized as SAE. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Hematology Parameters: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils, Platelets.</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the hematology parameters: basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Hematology Parameters: Erythrocytes.</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the hematology parameters: erythrocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Hematology Parameters: Erythrocytes Mean Corpuscular Volume (Erythrocyte MCV).</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the hematology parameters: erythrocyte MCV. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Hematology Parameter: Erythrocytes Mean Corpuscular Hemoglobin (Erythrocyte MCH)</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the hematology parameter: Erythrocyte MCH. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Hematology Parameter: Hematocrit</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the hematology parameter: hematocrit. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Hematology Parameter: Percentage of Reticulocytes</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the hematology parameter: percentage of reticulocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Hematology Parameter: Hemoglobin (Hb)</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the hematology parameter: Hb. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Clinical Chemistry Parameter: Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphate (ALP)</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: ALT, AST, and ALP. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Clinical Chemistry Parameters : Bicarbonate, Calcium, Chloride, Magnesium, Phosphate, Potassium, Sodium, Urea</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: bicarbonate, calcium, chloride, magnesium, phosphate, potassium, sodium, urea. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Cholesterol, Glucose, High Density Lipoprotein (HDL) Cholesterol, Low Density Cholesterol (LDL) Cholesterol, Triglycerides</measure>
    <time_frame>Baseline (Day -2) and Day 1 (96 hours) and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: cholesterol, glucose, HDL cholesterol, LDL cholesterol, triglycerides. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Chemistry Parameter: Glucose</measure>
    <time_frame>Baseline (Day -2) and Day 1 (96 hours) and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: glucose . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Clinical Chemistry Parameter: Bilirubin, Creatinine, Direct Bilirubin</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: bilirubin, creatinine, direct bilirubin . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Clinical Chemistry Parameter: Protein</measure>
    <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: Protein. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Number of Participants With Abnormal Urinalysis</measure>
    <time_frame>Up to Day 15</time_frame>
    <description>Urine samples were collected at given time points to analyze the abnormal findings for potential of hydrogen (pH), glucose, protein, blood, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase by dipstick.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Vital Signs: Diastolic Blood Pressure (DBP) and Systolic Blood Pressure (SBP)</measure>
    <time_frame>Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
    <description>SBP and DBP were measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Vital Signs: Pulse Rate</measure>
    <time_frame>Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
    <description>Pulse rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Vital Signs: Temperature</measure>
    <time_frame>Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
    <description>Temperature was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Vital Sign: Respiratory Rate</measure>
    <time_frame>Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
    <description>Respiratory rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Number of Participants With Abnormal Electrocardiogram (ECG) Findings</measure>
    <time_frame>Baseline (Day 1 predose), 1,2,4,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
    <description>12-lead ECGs were measured in a semi-supine position using an automated ECG machine after approximately 5 minutes of rest for the participant. Abnormal findings were categorized as clinically significant (CS) and not clinically significant (NCS).</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Number of Participants AEs and SAEs</measure>
    <time_frame>Up to Day 28</time_frame>
    <description>An AE is any untoward medical occurrence in a participant, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product. Any untoward event resulting in death, life threatening, requires hospitalization or prolongation of existing hospitalization, results in disability/incapacity, congenital anomaly/birth defect or any other situation according to medical or scientific judgment were categorized as SAE. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Abnormal Hematology Findings: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils, Platelets.</measure>
    <time_frame>Baseline (Day -2), Pre dose on Days 2,4,6,8,10,12,14 Day 14 : 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected at indicated time points to analyze the hematology parameters: basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Hematology Parameter: Erythrocytes</measure>
    <time_frame>Baseline (Day -2), Pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected at indicated time points to analyze the hematology parameters: Erythrocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Hematology Parameter: Erythrocytes MCV</measure>
    <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected at indicated time points to analyze the hematology parameters: Erythrocyte MCV. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Hematology Parameter: Erythrocytes Mean Corpuscular Hemoglobin (Erythrocyte MCH)</measure>
    <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected at indicated time points to analyze the hematology parameter: Erythrocyte MCH. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Hematology Parameter: Hematocrit</measure>
    <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected at indicated time points to analyze the hematology parameter: hematocrit. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Hematology Parameter: Percentage of Reticulocytes</measure>
    <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected to analyze the hematology parameter: percentage of reticulocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Hematology Parameter: Hb</measure>
    <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected at indicated time points to analyze the hematology parameter: Hb. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Chemistry Parameter: ALT, AST,ALP</measure>
    <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: ALT, AST,ALP. Day -2was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 1: Change From Baseline in Bicarbonate, Calcium, Chloride, Cholesterol, Magnesium, Phosphate, Potassium, Sodium, Urea</measure>
    <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: bicarbonate, calcium, chloride, magnesium, phosphate, potassium, sodium, urea. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Cholesterol, HDL Cholesterol, LDL Cholesterol, Triglycerides</measure>
    <time_frame>Baseline (Day -2), Day 8 (pre dose), Day 14 (48 hours) post dose and Follow up (Day 28)</time_frame>
    <description>Blood samples were collected at indicated time points to analyze the chemistry parameter: cholesterol, HDL cholesterol, LDL cholesterol, triglycerides. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Chemistry Parameter: Glucose</measure>
    <time_frame>Baseline (Day -2), Day 8 (predose), Day 14 (48 hours) post dose and Follow up (Day 28)</time_frame>
    <description>Blood samples were collected at indicated time points to analyze the chemistry parameter: glucose . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Chemistry Parameter: Bilirubin, Creatinine, Direct Bilirubin</measure>
    <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: bilirubin, creatinine, direct bilirubin . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Chemistry Parameter: Protein</measure>
    <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
    <description>Blood samples were collected to analyze the chemistry parameter: Protein. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Number of Participants With Abnormal Urinalysis</measure>
    <time_frame>Up to Day 28</time_frame>
    <description>Urine samples were collected analyze the abnormal findings for potential of hydrogen (pH), glucose, protein, blood, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase by dipstick.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Vital Signs: SBP and DBP</measure>
    <time_frame>Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12,and 14 (pre dose and 72 hours) and Follow up (Day 28)</time_frame>
    <description>SBP and DBP were measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Vital Sign: Pulse Rate</measure>
    <time_frame>Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12, and 14 (pre dose and 72 hours) and Follow up (Day 28)</time_frame>
    <description>Pulse rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Vital Sign: Temperature</measure>
    <time_frame>Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12, and 14 (pre dose and 72 hours) and Follow up (Day 28)</time_frame>
    <description>Temperature was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Change From Baseline in Vital Sign: Respiratory Rate</measure>
    <time_frame>Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12 and 14 (pre dose and 72 hours) and Follow up (Day 28)</time_frame>
    <description>Respiratory rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Part 2: Number of Participants With Abnormal ECG Findings</measure>
    <time_frame>Day 1 (0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4.5, 5, 5.5, 6, 8, 12, 24 hours); Pre-dose on Days 3, 4, 6, 8, 10, 12; Day 14: Pre-dose, 1, 2, 4.5, 5, 6, 12, 24, 48, 72 and 96 hours post-dose and follow up (Day 28)</time_frame>
    <description>12-lead ECG were obtained at given time points. Abnormal findings were categorized as clinically significant (CS) and not clinically significant (NCS).Results are presented treatment wise.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Part 1: Area Under the Plasma Concentration Time Curve (AUC) From Zero to 24 Hour (AUC[0-24]) of GSK3640254</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12,24 hours post-dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 1: AUC From Zero to Time of Last Sample Taken (AUC[0-Tlast]) of GSK3640254</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 1: AUC From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC[0-inf]) of GSK3640254</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 1: Apparent Terminal Phase Half-life (T1/2) of GSK3640254</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Most of the concentrations were below limit of quantification (BLQ) at this dose group this value and/ or %AUC extrapolated was &gt;20% for all participants so this value should be used with caution. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 1: Apparent Oral Clearance (CL/F) of GSK3640254</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 1: Maximum Observed Concentration (Cmax), Concentration of GSK3640254 at 24 Hours (C24) and Last Quantifiable Concentration (Clast) of GSK3640254</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 1: Time of Occurrence of Cmax (Tmax), Lag Time (Tlag), and Time to Reach Clast (Tlast) of GSK3640254</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: AUC(0-24) of GSK3640254: Day 1</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12 and 24 hours post-dose on Day 1</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Cmax, C24 of GSK3640254 on Day 1</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12 hours post-dose on Day 1</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Tmax, Tlag of GSK3640254 on Day 1</measure>
    <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12 hours post-dose on Day 1</time_frame>
    <description>Blood samples were collected at indicated timepoints and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Tmax GSK3640254 on Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Cmax of GSK3640254 on Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: AUC From Pre-dose to the End of the Dosing Interval at Steady State (AUC[0-tau]): Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Plasma Trough Concentration (Ctau) of GSK3640254: Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated timepoints and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The PK parameter name for Part 2 (Day 14) trough concentration was changed using Phoenix WinNonlin 8 from Ct to Ctrough. Day 15 Ctrough values were used for dose proportionality and time to steady-state assessments.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: T1/2 of GSK3640254: Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: CL/F of GSK3640254: Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 1: Dose Proportionality (AUC[0-inf]) Following Single Dose of GSK3640254 on Day 1</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 1: Dose Proportionality (AUC0-24) Following Single Dose of GSK3640254 on Day 1</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24 hours post dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 1: Dose Proportionality for Cmax Following Single Dose of GSK3640254 on Day 1</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Dose Proportionality (AUC0-tau) Following Repeated Dose of GSK3640254 on Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Dose Proportionality (Ctrough) Following Repeated Dose of GSK3640254 on Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Dose Proportionality (Cmax) Following Repeated Dose of GSK3640254 on Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Accumulation Ratio of AUC(0-tau) (R [AUC{0-TAU}]) From Day 1 to Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 14 and Day 1, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Accumulation Ratio of Cmax (R [CMAX]) From Day 1 to Day 14</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 14 and Day 1, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Accumulation Ratio of C(Tau) (R[CTAU]) From Day 2 to Day 15</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 15 dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 15 and Day 2, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Pre-dose Concentration of GSK3640254 on Day 2 to Day 14</measure>
    <time_frame>Pre-dose on Days 2,3,4,6,8,10,12 and 14</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Dose Proportionality (Cmax) Following Repeated Dose of GSK3640254 at Day 1</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Part 2: Dose Proportionality (AUC0-24) Following Repeated Dose of GSK3640254 at Day 1</measure>
    <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose</time_frame>
    <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
  </secondary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Actual">78</enrollment>
  <condition>Infection, Human Immunodeficiency Virus</condition>
  <condition>HIV Infections</condition>
  <arm_group>
    <arm_group_label>Subjects in cohort 1-2: Part 1</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Eligible subjects will participate in cohort 1 or 2 and each of these two cohorts will contain up to four escalating doses of GSK3640254. In each cohort, 6 subjects will be randomized to receive single oral dose of GSK3640254 and 2 subjects will be randomized to receive placebo. Hence, each subject in cohort 1 and 2 will receive up to 3 escalating doses of GSK3640254 and one placebo in crossover manner.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>GSK3640254 receivers (cohort 3-6 and expansion): Part 2</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Eligible subjects will participate in one of the 4 cohorts (3,4,5,6). In each cohort, 6 subjects will be randomized to receive a once-daily oral dose of GSK3640254 for 14 days. After the safety data of cohort 3-6 is available, 18 eligible subjects will be randomized to receive once daily oral dose of GSK3640254 for 14 days in expansion cohort.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Subjects receiving placebo (cohort 3-6): Part 2</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Eligible subjects will participate in one of the 4 cohorts (3,4,5,6). In each cohort, 2 subjects will be randomized to receive a once-daily oral dose of placebo for 14 days. After the safety data of cohort 3-6 is available, 6 eligible subjects will be randomized to receive once daily oral dose of placebo for 14 days in expansion cohort.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>GSK3640254</intervention_name>
    <description>GSK3640254 is a capsule available in 1 milligram (mg), 10 mg and 100 mg dosing strength. GSK3640254 capsule will be given via oral route during each dosing day with approximately 240 mL of water.</description>
    <arm_group_label>GSK3640254 receivers (cohort 3-6 and expansion): Part 2</arm_group_label>
    <arm_group_label>Subjects in cohort 1-2: Part 1</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Placebo</intervention_name>
    <description>Placebo capsule matching to the study treatment will be given via oral route during each dosing day with approximately 240 mL of water.</description>
    <arm_group_label>Subjects in cohort 1-2: Part 1</arm_group_label>
    <arm_group_label>Subjects receiving placebo (cohort 3-6): Part 2</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Subjects must be 18 to 55 years of age inclusive, at the time of signing the informed&#xD;
             consent.&#xD;
&#xD;
          -  Subjects who are overtly healthy as determined by medical evaluation including medical&#xD;
             history and psychiatric history, physical examination, laboratory tests, and 24 hour&#xD;
             Holter monitoring.&#xD;
&#xD;
          -  Body weight &gt;=50.0 kilogram (kg) (110 pounds) for men and 45.0kg (99 pounds) for women&#xD;
             and body mass index (BMI) within the range 18.5-32.0 kg per meter square (kg/m^2)&#xD;
             (inclusive).&#xD;
&#xD;
          -  Male or female subjects. A male subject must agree to use contraception during the&#xD;
             treatment period and for at least 14 weeks following the last dose, corresponding to&#xD;
             the time needed to eliminate study treatment for potential genotoxic and teratogenic&#xD;
             study treatments plus an additional 90 days (spermatogenesis cycle). In addition, male&#xD;
             subjects must refrain from donating sperm during this period. A female subject is&#xD;
             eligible to participate if she is not a woman of childbearing potential (WOCBP).&#xD;
&#xD;
          -  Capable of giving signed informed consent.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Alanine transaminase (ALT) &gt;1.5 into upper limit of normal (ULN).&#xD;
&#xD;
          -  Bilirubin &gt;1.5 into ULN (isolated bilirubin &gt;1.5 into ULN is acceptable if bilirubin&#xD;
             is fractionated and direct bilirubin &lt;35%).&#xD;
&#xD;
          -  Current or chronic history of liver disease, or known hepatic or biliary&#xD;
             abnormalities.&#xD;
&#xD;
          -  Pre-existing clinically relevant, in the opinion of the primary investigator (PI),&#xD;
             gastro-intestinal pathology or diagnosis - example irritable bowel syndrome,&#xD;
             inflammatory bowel disease, and/or significant Baseline signs and symptoms.&#xD;
&#xD;
          -  Medical history of cardiac arrhythmias or cardiac disease or a family or personal&#xD;
             history of long QT syndrome.&#xD;
&#xD;
          -  Any known or suspected pre-existing psychiatric condition.&#xD;
&#xD;
          -  Any other clinical condition (including but not limited to active substance use) or&#xD;
             prior therapy that, in the opinion of the Investigator, would make the subject&#xD;
             unsuitable for the study; unable to comply with dosing requirements; or unable to&#xD;
             comply with study visits; or a condition that could affect the absorption,&#xD;
             distribution, metabolism or excretion of the drug.&#xD;
&#xD;
          -  Unable to refrain from the use of prescription or non-prescription drugs (with the&#xD;
             exception of paracetamol), including vitamins, herbal and dietary supplements&#xD;
             (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme&#xD;
             inducer) or 5 half-lives (whichever is longer) prior to the first dose of study&#xD;
             medication and for the duration of the study, unless in the opinion of the&#xD;
             Investigator and ViiV Healthcare Sponsor and medical monitor, the medication will not&#xD;
             interfere with the study medications, procedures, or compromise subject safety.&#xD;
&#xD;
          -  Unwillingness to abstain from ingestion of any food or drink containing grapefruit and&#xD;
             grapefruit juice, Seville oranges, blood oranges, or pomelos within 7 days prior to&#xD;
             the first dose of study treatment(s) or until the end of the study.&#xD;
&#xD;
          -  Participation in another concurrent clinical study or prior clinical study (with the&#xD;
             exception of imaging trials) prior to the first dosing day in the current study: 30&#xD;
             days, 5 half-lives or twice the duration of the biological effect of the&#xD;
             investigational product (whichever is longer).&#xD;
&#xD;
          -  Where participation in the study would result in donation of blood or blood products&#xD;
             in excess of 500 milliliter (mL) within 56 days.&#xD;
&#xD;
          -  Presence of hepatitis B surface antigen (HBsAg), or positive hepatitis C antibody test&#xD;
             result at screening or within 3 months prior to first dose of study treatment.&#xD;
&#xD;
          -  A positive pre-study drug/alcohol screen.&#xD;
&#xD;
          -  A positive test for a diagnostic HIV-1 polymerase chain reaction (PCR).&#xD;
&#xD;
          -  Exposure to more than four new chemical entities within 12 months prior to the first&#xD;
             dosing day.&#xD;
&#xD;
          -  Exclusion criteria for screening ECG: Heart rate &lt;45 or &gt;100 beats per minute (bpm)&#xD;
             for males and &lt;50 or &gt;100 bpm for females; PR interval &lt;120 or &gt;220 millisecond&#xD;
             (msec); QRS duration &lt;70 or &gt;120 msec; the Fridericia's QT correction formula (QTcF)&#xD;
             interval &gt;450 msec.&#xD;
&#xD;
          -  Evidence of previous myocardial infarction (does not include ST segment changes&#xD;
             associated with re-polarization).&#xD;
&#xD;
          -  Any conduction abnormality (including but not specific to left or right complete&#xD;
             bundle branch block, Atrioventricular block [2nd degree or higher],&#xD;
             Wolff-Parkinson-White [WPW] syndrome).&#xD;
&#xD;
          -  Sinus Pauses &gt;3 seconds.&#xD;
&#xD;
          -  Any significant arrhythmia which, in the opinion of the Investigator or&#xD;
             GlaxoSmithKline/ViiV medical monitor, will interfere with the safety for the&#xD;
             individual subject.&#xD;
&#xD;
          -  Non-sustained or sustained ventricular tachycardia (3 consecutive ventricular ectopic&#xD;
             beats).&#xD;
&#xD;
          -  History of regular alcohol consumption within 6 months of the study defined as: an&#xD;
             average weekly intake of &gt;14 units. One unit is equivalent to 8 gram of alcohol: a&#xD;
             half-pint approximately 240 mL of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure&#xD;
             of spirits.&#xD;
&#xD;
          -  Regular use of tobacco- or nicotine-containing products within 3 months prior to&#xD;
             screening.&#xD;
&#xD;
          -  History of sensitivity to any of the study medications, or components thereof or a&#xD;
             history of drug or other allergy that, in the opinion of the Investigator or medical&#xD;
             monitor, contraindicates their participation.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>55 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>GSK Clinical Trials</last_name>
    <role>Study Director</role>
    <affiliation>ViiV Healthcare</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>GSK Investigational Site</name>
      <address>
        <city>Cambridge</city>
        <zip>CB2 2GG</zip>
        <country>United Kingdom</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United Kingdom</country>
  </location_countries>
  <reference>
    <citation>Joshi SR, Fernando D, Igwe S, McKenzie L, Krishnatry AS, Halliday F, Zhan J, Greene TJ, Xu J, Ferron-Brady G, Lataillade M, Min S. Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next-generation HIV-1 maturation inhibitor. Pharmacol Res Perspect. 2020 Dec;8(6):e00671. doi: 10.1002/prp2.671.</citation>
    <PMID>33200887</PMID>
  </reference>
  <verification_date>May 2021</verification_date>
  <study_first_submitted>July 24, 2017</study_first_submitted>
  <study_first_submitted_qc>July 24, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">July 27, 2017</study_first_posted>
  <results_first_submitted>September 9, 2019</results_first_submitted>
  <results_first_submitted_qc>October 16, 2019</results_first_submitted_qc>
  <results_first_posted type="Actual">October 18, 2019</results_first_posted>
  <last_update_submitted>May 28, 2021</last_update_submitted>
  <last_update_submitted_qc>May 28, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">June 10, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>FTIH</keyword>
  <keyword>Healthy</keyword>
  <keyword>Tolerability</keyword>
  <keyword>Dose-escalation</keyword>
  <keyword>HIV-1</keyword>
  <keyword>Safety</keyword>
  <keyword>PK</keyword>
  <keyword>GSK3640254</keyword>
  <keyword>Maturation inhibitor</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Infections</mesh_term>
    <mesh_term>Communicable Diseases</mesh_term>
    <mesh_term>HIV Infections</mesh_term>
    <mesh_term>Acquired Immunodeficiency Syndrome</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Yes</sharing_ipd>
    <ipd_description>IPD for this study is available via the Clinical Study Data Request site.</ipd_description>
    <ipd_info_type>Study Protocol</ipd_info_type>
    <ipd_info_type>Statistical Analysis Plan (SAP)</ipd_info_type>
    <ipd_info_type>Informed Consent Form (ICF)</ipd_info_type>
    <ipd_info_type>Clinical Study Report (CSR)</ipd_info_type>
    <ipd_time_frame>IPD is available via the Clinical Study Data Request site (copy the URL below to your browser)</ipd_time_frame>
    <ipd_access_criteria>Access is provided after a research proposal is submitted and has received approval from the Independent Review Panel and after a Data Sharing Agreement is in place. Access is provided for an initial period of 12 months but an extension can be granted, when justified, for up to another 12 months.</ipd_access_criteria>
    <ipd_url>https://clinicalstudydatarequest.com/Posting.aspx?ID=20826</ipd_url>
  </patient_data>
  <provided_document_section>
    <provided_document>
      <document_type>Study Protocol</document_type>
      <document_has_protocol>Yes</document_has_protocol>
      <document_has_icf>No</document_has_icf>
      <document_has_sap>No</document_has_sap>
      <document_date>May 17, 2018</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/43/NCT03231943/Prot_000.pdf</document_url>
    </provided_document>
    <provided_document>
      <document_type>Statistical Analysis Plan</document_type>
      <document_has_protocol>No</document_has_protocol>
      <document_has_icf>No</document_has_icf>
      <document_has_sap>Yes</document_has_sap>
      <document_date>September 8, 2018</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/43/NCT03231943/SAP_001.pdf</document_url>
    </provided_document>
  </provided_document_section>

  <clinical_results>

    <participant_flow>
      <recruitment_details>This study was conducted to evaluate safety, tolerability and pharmacokinetic (PK) of GSK3640254 in healthy participants at one center in United Kingdom from 19-September-2017 to 09-September-2018</recruitment_details>
      <pre_assignment_details>Total 78 participants were enrolled in the study. This was a two part study, Part 1 was single ascending dose (SAD) and Part 2 was multiple ascending dose (MAD).</pre_assignment_details>
      <group_list>
        <group group_id="P1">
          <title>Part 1: Placebo Followed by GSK3640254 10mg/100mg/400mg</title>
          <description>Participants received single dose placebo followed by GSK3640254 10 milligram (mg) followed by GSK3640254 100 mg followed by GSK3640254 400 mg oral dose on Day 1</description>
        </group>
        <group group_id="P2">
          <title>Part 1: GSK3640254 1mg/ Placebo /100 mg/400 mg</title>
          <description>Participants received single dose GSK3640254 1mg followed by placebo followed by GSK3640254 100 mg followed by GSK3640254 400 mg oral dose on Day 1</description>
        </group>
        <group group_id="P3">
          <title>Part 1: GSK3640254 1mg/10mg/Placebo /400mg</title>
          <description>Participants received single dose GSK3640254 1mg followed by GSK3640254 10 mg followed by placebo followed by GSK3640254 400 mg oral dose on Day 1</description>
        </group>
        <group group_id="P4">
          <title>Part 1: GSK3640254 1mg/10mg/100mg/Placebo</title>
          <description>Participants received single dose GSK3640254 1mg followed by GSK3640254 10 mg followed by GSK3640254 100 mg followed by placebo as oral dose on Day 1</description>
        </group>
        <group group_id="P5">
          <title>Part 1: Placebo/ GSK3640254 30mg/200 mg/700 mg</title>
          <description>Participants received single dose placebo followed by GSK3640254 30mg followed by GSK3640254 200 mg followed by GSK3640254 700 mg as oral dose on Day 1</description>
        </group>
        <group group_id="P6">
          <title>Part1:GSK3640254 3mg/Placebo/200mg/700mg</title>
          <description>Participants received single dose GSK3640254 3mg followed by placebo followed by GSK3640254 200 mg followed by GSK3640254 700 mg as oral dose on Day 1</description>
        </group>
        <group group_id="P7">
          <title>Part 1:GSK3640254 3mg/30mg/Placebo/GSK3640254 700mg</title>
          <description>Participants received single dose GSK3640254 3 mg followed by GSK3640254 30 mg followed by placebo followed by GSK3640254 700 mg as oral dose on Day 1</description>
        </group>
        <group group_id="P8">
          <title>Part 1:GSK3640254 3mg/30mg/GSK3640254 200mg/Placebo</title>
          <description>Participants received single dose GSK3640254 3mg followed by GSK3640254 30mg followed by GSK3640254 200mg followed by placebo as oral dose on Day 1</description>
        </group>
        <group group_id="P9">
          <title>Part 2: Repeated Dose GSK3640254 50 mg</title>
          <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
        </group>
        <group group_id="P10">
          <title>Part 2: Repeated Dose GSK3640254 100mg</title>
          <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
        </group>
        <group group_id="P11">
          <title>Part 2: GSK3640254 200mg + Expansion</title>
          <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
        </group>
        <group group_id="P12">
          <title>Part 2: Repeated Dose GSK3640254 320mg</title>
          <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
        </group>
        <group group_id="P13">
          <title>Part 2: Repeated Dose Placebo</title>
          <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
        </group>
      </group_list>
      <period_list>
        <period>
          <title>Part 1, Period 1 (up to Day 15)</title>
          <milestone_list>
            <milestone>
              <title>STARTED</title>
              <participants_list>
                <participants group_id="P1" count="2"/>
                <participants group_id="P2" count="2"/>
                <participants group_id="P3" count="2"/>
                <participants group_id="P4" count="2"/>
                <participants group_id="P5" count="2"/>
                <participants group_id="P6" count="2"/>
                <participants group_id="P7" count="2"/>
                <participants group_id="P8" count="2"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="2"/>
                <participants group_id="P2" count="2"/>
                <participants group_id="P3" count="2"/>
                <participants group_id="P4" count="2"/>
                <participants group_id="P5" count="2"/>
                <participants group_id="P6" count="2"/>
                <participants group_id="P7" count="2"/>
                <participants group_id="P8" count="2"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>NOT COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="0"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
          </milestone_list>
        </period>
        <period>
          <title>Part 1, Period 2 (up to Day 30)</title>
          <milestone_list>
            <milestone>
              <title>STARTED</title>
              <participants_list>
                <participants group_id="P1" count="2"/>
                <participants group_id="P2" count="2"/>
                <participants group_id="P3" count="2"/>
                <participants group_id="P4" count="2"/>
                <participants group_id="P5" count="2"/>
                <participants group_id="P6" count="2"/>
                <participants group_id="P7" count="2"/>
                <participants group_id="P8" count="2"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="2"/>
                <participants group_id="P2" count="0">Two participants withdrawn were replaced</participants>
                <participants group_id="P3" count="1">One participant withdrawn was replaced</participants>
                <participants group_id="P4" count="2"/>
                <participants group_id="P5" count="2"/>
                <participants group_id="P6" count="2"/>
                <participants group_id="P7" count="2"/>
                <participants group_id="P8" count="2"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>NOT COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="2"/>
                <participants group_id="P3" count="1"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
          </milestone_list>
          <drop_withdraw_reason_list>
            <drop_withdraw_reason>
              <title>Adverse Event</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="1"/>
                <participants group_id="P3" count="1"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </drop_withdraw_reason>
            <drop_withdraw_reason>
              <title>Withdrawal by Subject</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="1"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </drop_withdraw_reason>
          </drop_withdraw_reason_list>
        </period>
        <period>
          <title>Part 1, Period 3 (up to Day 45)</title>
          <milestone_list>
            <milestone>
              <title>STARTED</title>
              <participants_list>
                <participants group_id="P1" count="2"/>
                <participants group_id="P2" count="2"/>
                <participants group_id="P3" count="2"/>
                <participants group_id="P4" count="2"/>
                <participants group_id="P5" count="2"/>
                <participants group_id="P6" count="2"/>
                <participants group_id="P7" count="2"/>
                <participants group_id="P8" count="2"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="1">One participant withdrawn was replaced</participants>
                <participants group_id="P2" count="2"/>
                <participants group_id="P3" count="2"/>
                <participants group_id="P4" count="2"/>
                <participants group_id="P5" count="2"/>
                <participants group_id="P6" count="2"/>
                <participants group_id="P7" count="2"/>
                <participants group_id="P8" count="2"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>NOT COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="1"/>
                <participants group_id="P2" count="0"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
          </milestone_list>
          <drop_withdraw_reason_list>
            <drop_withdraw_reason>
              <title>Adverse Event</title>
              <participants_list>
                <participants group_id="P1" count="1"/>
                <participants group_id="P2" count="0"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </drop_withdraw_reason>
          </drop_withdraw_reason_list>
        </period>
        <period>
          <title>Part 1 Period 4 (up to Day 60)</title>
          <milestone_list>
            <milestone>
              <title>STARTED</title>
              <participants_list>
                <participants group_id="P1" count="2"/>
                <participants group_id="P2" count="2"/>
                <participants group_id="P3" count="2"/>
                <participants group_id="P4" count="2"/>
                <participants group_id="P5" count="2"/>
                <participants group_id="P6" count="2"/>
                <participants group_id="P7" count="2"/>
                <participants group_id="P8" count="2"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="2"/>
                <participants group_id="P2" count="2"/>
                <participants group_id="P3" count="2"/>
                <participants group_id="P4" count="2"/>
                <participants group_id="P5" count="2"/>
                <participants group_id="P6" count="2"/>
                <participants group_id="P7" count="2"/>
                <participants group_id="P8" count="2"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>NOT COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="0"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
          </milestone_list>
        </period>
        <period>
          <title>Part 2</title>
          <milestone_list>
            <milestone>
              <title>STARTED</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="0"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="6"/>
                <participants group_id="P10" count="6"/>
                <participants group_id="P11" count="25"/>
                <participants group_id="P12" count="7"/>
                <participants group_id="P13" count="14"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="0"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="6"/>
                <participants group_id="P10" count="6"/>
                <participants group_id="P11" count="24"/>
                <participants group_id="P12" count="6"/>
                <participants group_id="P13" count="14"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>NOT COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="0"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="1"/>
                <participants group_id="P12" count="1"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </milestone>
          </milestone_list>
          <drop_withdraw_reason_list>
            <drop_withdraw_reason>
              <title>Adverse Event</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="0"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="1"/>
                <participants group_id="P12" count="0"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </drop_withdraw_reason>
            <drop_withdraw_reason>
              <title>Withdrawal by Subject</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="0"/>
                <participants group_id="P3" count="0"/>
                <participants group_id="P4" count="0"/>
                <participants group_id="P5" count="0"/>
                <participants group_id="P6" count="0"/>
                <participants group_id="P7" count="0"/>
                <participants group_id="P8" count="0"/>
                <participants group_id="P9" count="0"/>
                <participants group_id="P10" count="0"/>
                <participants group_id="P11" count="0"/>
                <participants group_id="P12" count="1"/>
                <participants group_id="P13" count="0"/>
              </participants_list>
            </drop_withdraw_reason>
          </drop_withdraw_reason_list>
        </period>
      </period_list>
    </participant_flow>

    <baseline>
      <group_list>
        <group group_id="B1">
          <title>Part 1: Cohort 1</title>
          <description>Participants received GSK3640254 1mg, GSK3640254 10 mg, GSK3640254 100mg, GSK3640254 400mg as ascending single dose on Day 1 of each period, each participant received placebo in one of the four periods</description>
        </group>
        <group group_id="B2">
          <title>Part 1: Cohort 2</title>
          <description>Participants received GSK3640254 3mg, GSK3640254 30 mg, GSK3640254 200mg, GSK3640254 700mg as ascending single dose on Day 1 of each period, each participant received placebo in one of the four periods</description>
        </group>
        <group group_id="B3">
          <title>Part 2: Repeated Dose GSK3640254 50 mg</title>
          <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
        </group>
        <group group_id="B4">
          <title>Part 2: Repeated Dose GSK3640254 100 mg</title>
          <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
        </group>
        <group group_id="B5">
          <title>Part 2: Repeated Dose GSK3640254 200 mg + Expansion</title>
          <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
        </group>
        <group group_id="B6">
          <title>Part 2: Repeated Dose GSK3640254 320 mg</title>
          <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
        </group>
        <group group_id="B7">
          <title>Part 2: Repeated Dose Placebo</title>
          <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
        </group>
        <group group_id="B8">
          <title>Total</title>
          <description>Total of all reporting groups</description>
        </group>
      </group_list>
      <analyzed_list>
        <analyzed>
          <units>Participants</units>
          <scope>Overall</scope>
          <count_list>
            <count group_id="B1" value="12"/>
            <count group_id="B2" value="8"/>
            <count group_id="B3" value="6"/>
            <count group_id="B4" value="6"/>
            <count group_id="B5" value="25"/>
            <count group_id="B6" value="7"/>
            <count group_id="B7" value="14"/>
            <count group_id="B8" value="78"/>
          </count_list>
        </analyzed>
      </analyzed_list>
      <measure_list>
        <measure>
          <title>Age</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>&lt;=18 years</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                    <measurement group_id="B4" value="0"/>
                    <measurement group_id="B5" value="0"/>
                    <measurement group_id="B6" value="0"/>
                    <measurement group_id="B7" value="0"/>
                    <measurement group_id="B8" value="0"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Between 18 and 65 years</title>
                  <measurement_list>
                    <measurement group_id="B1" value="12"/>
                    <measurement group_id="B2" value="8"/>
                    <measurement group_id="B3" value="6"/>
                    <measurement group_id="B4" value="6"/>
                    <measurement group_id="B5" value="25"/>
                    <measurement group_id="B6" value="7"/>
                    <measurement group_id="B7" value="14"/>
                    <measurement group_id="B8" value="78"/>
                  </measurement_list>
                </category>
                <category>
                  <title>&gt;=65 years</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                    <measurement group_id="B4" value="0"/>
                    <measurement group_id="B5" value="0"/>
                    <measurement group_id="B6" value="0"/>
                    <measurement group_id="B7" value="0"/>
                    <measurement group_id="B8" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Sex: Female, Male</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>Female</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                    <measurement group_id="B4" value="0"/>
                    <measurement group_id="B5" value="0"/>
                    <measurement group_id="B6" value="0"/>
                    <measurement group_id="B7" value="0"/>
                    <measurement group_id="B8" value="0"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Male</title>
                  <measurement_list>
                    <measurement group_id="B1" value="12"/>
                    <measurement group_id="B2" value="8"/>
                    <measurement group_id="B3" value="6"/>
                    <measurement group_id="B4" value="6"/>
                    <measurement group_id="B5" value="25"/>
                    <measurement group_id="B6" value="7"/>
                    <measurement group_id="B7" value="14"/>
                    <measurement group_id="B8" value="78"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Race/Ethnicity, Customized</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <title>ASIAN - CENTRAL/SOUTH ASIAN HERITAGE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="2"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                    <measurement group_id="B4" value="0"/>
                    <measurement group_id="B5" value="0"/>
                    <measurement group_id="B6" value="1"/>
                    <measurement group_id="B7" value="0"/>
                    <measurement group_id="B8" value="3"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>BLACK OR AFRICAN AMERICAN</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="1"/>
                    <measurement group_id="B2" value="1"/>
                    <measurement group_id="B3" value="1"/>
                    <measurement group_id="B4" value="1"/>
                    <measurement group_id="B5" value="4"/>
                    <measurement group_id="B6" value="0"/>
                    <measurement group_id="B7" value="2"/>
                    <measurement group_id="B8" value="10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>WHITE-WHITE/CAUCASIAN/EUROPEAN HERITAGE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="9"/>
                    <measurement group_id="B2" value="6"/>
                    <measurement group_id="B3" value="5"/>
                    <measurement group_id="B4" value="5"/>
                    <measurement group_id="B5" value="20"/>
                    <measurement group_id="B6" value="5"/>
                    <measurement group_id="B7" value="11"/>
                    <measurement group_id="B8" value="61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>MULTIPLE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="1"/>
                    <measurement group_id="B3" value="0"/>
                    <measurement group_id="B4" value="0"/>
                    <measurement group_id="B5" value="0"/>
                    <measurement group_id="B6" value="0"/>
                    <measurement group_id="B7" value="0"/>
                    <measurement group_id="B8" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ASIAN - EAST ASIAN HERITAGE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                    <measurement group_id="B4" value="0"/>
                    <measurement group_id="B5" value="1"/>
                    <measurement group_id="B6" value="0"/>
                    <measurement group_id="B7" value="0"/>
                    <measurement group_id="B8" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ASIAN - SOUTH EAST ASIAN HERITAGE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                    <measurement group_id="B4" value="0"/>
                    <measurement group_id="B5" value="0"/>
                    <measurement group_id="B6" value="0"/>
                    <measurement group_id="B7" value="1"/>
                    <measurement group_id="B8" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>WHITE - ARABIC/NORTH AFRICAN HERITAGE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                    <measurement group_id="B4" value="0"/>
                    <measurement group_id="B5" value="0"/>
                    <measurement group_id="B6" value="1"/>
                    <measurement group_id="B7" value="0"/>
                    <measurement group_id="B8" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </measure_list>
    </baseline>

    <outcome_list>
      <outcome>
        <type>Primary</type>
        <title>Part 1:Number of Participants With Adverse Events (AEs) and Serious AEs (SAEs)</title>
        <description>An AE is any untoward medical occurrence in a subject, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product. Any untoward event resulting in death, life threatening, requires hospitalization or prolongation of existing hospitalization, results in disability/incapacity, congenital anomaly/birth defect or any other situation according to medical or scientific judgment will be categorized as SAE. Results are presented treatment wise.</description>
        <time_frame>Up to Day 15</time_frame>
        <population>Safety Population. It is comprised of all participants who received at least one dose of a study treatment.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1:Number of Participants With Adverse Events (AEs) and Serious AEs (SAEs)</title>
          <description>An AE is any untoward medical occurrence in a subject, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product. Any untoward event resulting in death, life threatening, requires hospitalization or prolongation of existing hospitalization, results in disability/incapacity, congenital anomaly/birth defect or any other situation according to medical or scientific judgment will be categorized as SAE. Results are presented treatment wise.</description>
          <population>Safety Population. It is comprised of all participants who received at least one dose of a study treatment.</population>
          <units>Participants</units>
          <param>Count of Participants</param>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>AE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3"/>
                    <measurement group_id="O2" value="2"/>
                    <measurement group_id="O3" value="4"/>
                    <measurement group_id="O4" value="3"/>
                    <measurement group_id="O5" value="3"/>
                    <measurement group_id="O6" value="4"/>
                    <measurement group_id="O7" value="4"/>
                    <measurement group_id="O8" value="1"/>
                    <measurement group_id="O9" value="7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SAE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Hematology Parameters: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils, Platelets.</title>
        <description>Blood samples were collected to analyze the hematology parameters: basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Hematology Parameters: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils, Platelets.</title>
          <description>Blood samples were collected to analyze the hematology parameters: basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>10^9 cells /Liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Basophils, 24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.002" spread="0.0075"/>
                    <measurement group_id="O2" value="-0.002" spread="0.0147"/>
                    <measurement group_id="O3" value="0.005" spread="0.0084"/>
                    <measurement group_id="O4" value="-0.002" spread="0.0075"/>
                    <measurement group_id="O5" value="-0.007" spread="0.0103"/>
                    <measurement group_id="O6" value="0.002" spread="0.0098"/>
                    <measurement group_id="O7" value="-0.002" spread="0.0148"/>
                    <measurement group_id="O8" value="-0.007" spread="0.0121"/>
                    <measurement group_id="O9" value="0.001" spread="0.0106"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, 48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.002" spread="0.0098"/>
                    <measurement group_id="O2" value="0.012" spread="0.0117"/>
                    <measurement group_id="O3" value="0.010" spread="0.0187"/>
                    <measurement group_id="O4" value="-0.007" spread="0.0103"/>
                    <measurement group_id="O5" value="-0.005" spread="0.00550"/>
                    <measurement group_id="O6" value="0.007" spread="0.0082"/>
                    <measurement group_id="O7" value="0.000" spread="0.0167"/>
                    <measurement group_id="O8" value="0.000" spread="0.0110"/>
                    <measurement group_id="O9" value="0.005" spread="0.0115"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.003" spread="0.0103"/>
                    <measurement group_id="O2" value="0.000" spread="0.0155"/>
                    <measurement group_id="O3" value="-0.003" spread="0.0103"/>
                    <measurement group_id="O4" value="-0.002" spread="0.0147"/>
                    <measurement group_id="O5" value="-0.005" spread="0.0152"/>
                    <measurement group_id="O6" value="0.002" spread="0.0098"/>
                    <measurement group_id="O7" value="-0.007" spread="0.0052"/>
                    <measurement group_id="O8" value="-0.002" spread="0.0147"/>
                    <measurement group_id="O9" value="0.004" spread="0.0118"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, Day 15,n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.002" spread="0.0133"/>
                    <measurement group_id="O2" value="0.012" spread="0.0117"/>
                    <measurement group_id="O3" value="0.000" spread="0.0110"/>
                    <measurement group_id="O4" value="0.002" spread="0.0098"/>
                    <measurement group_id="O5" value="-0.007" spread="0.0082"/>
                    <measurement group_id="O6" value="0.010" spread="0.0063"/>
                    <measurement group_id="O7" value="-0.005" spread="0.0207"/>
                    <measurement group_id="O8" value="-0.005" spread="0.0084"/>
                    <measurement group_id="O9" value="0.007" spread="0.0178"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, 24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.022" spread="0.1876"/>
                    <measurement group_id="O2" value="0.012" spread="0.0376"/>
                    <measurement group_id="O3" value="0.005" spread="0.0650"/>
                    <measurement group_id="O4" value="0.015" spread="0.0489"/>
                    <measurement group_id="O5" value="0.008" spread="0.0508"/>
                    <measurement group_id="O6" value="-0.017" spread="0.0186"/>
                    <measurement group_id="O7" value="-0.032" spread="0.0642"/>
                    <measurement group_id="O8" value="0.023" spread="0.0266"/>
                    <measurement group_id="O9" value="0.005" spread="0.0648"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, 48 hour, 6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.032" spread="0.1982"/>
                    <measurement group_id="O2" value="0.018" spread="0.0731"/>
                    <measurement group_id="O3" value="0.008" spread="0.0497"/>
                    <measurement group_id="O4" value="0.010" spread="0.0544"/>
                    <measurement group_id="O5" value="0.010" spread="0.0544"/>
                    <measurement group_id="O6" value="0.020" spread="0.0346"/>
                    <measurement group_id="O7" value="-0.030" spread="0.0443"/>
                    <measurement group_id="O8" value="0.012" spread="0.0796"/>
                    <measurement group_id="O9" value="0.037" spread="0.0266"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.052" spread="0.1970"/>
                    <measurement group_id="O2" value="0.035" spread="0.0575"/>
                    <measurement group_id="O3" value="-0.012" spread="0.0591"/>
                    <measurement group_id="O4" value="0.003" spread="0.0602"/>
                    <measurement group_id="O5" value="0.013" spread="0.0207"/>
                    <measurement group_id="O6" value="-0.018" spread="0.0382"/>
                    <measurement group_id="O7" value="0.028" spread="0.0861"/>
                    <measurement group_id="O8" value="0.022" spread="0.0256"/>
                    <measurement group_id="O9" value="0.013" spread="0.0656"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.023" spread="0.1328"/>
                    <measurement group_id="O2" value="0.012" spread="0.0534"/>
                    <measurement group_id="O3" value="0.000" spread="0.0335"/>
                    <measurement group_id="O4" value="0.020" spread="0.0921"/>
                    <measurement group_id="O5" value="0.018" spread="0.0542"/>
                    <measurement group_id="O6" value="0.012" spread="0.0471"/>
                    <measurement group_id="O7" value="-0.032" spread="0.0960"/>
                    <measurement group_id="O8" value="-0.012" spread="0.0354"/>
                    <measurement group_id="O9" value="-0.015" spread="0.0791"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, 24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.592" spread="0.9839"/>
                    <measurement group_id="O2" value="0.877" spread="0.7228"/>
                    <measurement group_id="O3" value="-0.910" spread="1.1691"/>
                    <measurement group_id="O4" value="0.058" spread="0.8437"/>
                    <measurement group_id="O5" value="0.132" spread="0.8528"/>
                    <measurement group_id="O6" value="-0.742" spread="2.2552"/>
                    <measurement group_id="O7" value="-0.088" spread="0.4219"/>
                    <measurement group_id="O8" value="0.078" spread="0.6916"/>
                    <measurement group_id="O9" value="0.079" spread="0.8700"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, 48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.603" spread="1.3012"/>
                    <measurement group_id="O2" value="0.388" spread="0.8506"/>
                    <measurement group_id="O3" value="-0.878" spread="1.2611"/>
                    <measurement group_id="O4" value="-0.292" spread="0.9476"/>
                    <measurement group_id="O5" value="0.307" spread="1.1555"/>
                    <measurement group_id="O6" value="-0.673" spread="1.8656"/>
                    <measurement group_id="O7" value="1.220" spread="2.6559"/>
                    <measurement group_id="O8" value="0.312" spread="0.6725"/>
                    <measurement group_id="O9" value="0.104" spread="0.8442"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.693" spread="1.1514"/>
                    <measurement group_id="O2" value="0.953" spread="0.8659"/>
                    <measurement group_id="O3" value="-0.897" spread="0.9192"/>
                    <measurement group_id="O4" value="-0.107" spread="0.9821"/>
                    <measurement group_id="O5" value="0.503" spread="1.1885"/>
                    <measurement group_id="O6" value="-0.458" spread="2.3501"/>
                    <measurement group_id="O7" value="0.390" spread="1.3833"/>
                    <measurement group_id="O8" value="0.557" spread="0.5838"/>
                    <measurement group_id="O9" value="0.272" spread="0.8542"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.348" spread="1.0652"/>
                    <measurement group_id="O2" value="0.502" spread="1.2216"/>
                    <measurement group_id="O3" value="-0.113" spread="1.8444"/>
                    <measurement group_id="O4" value="-0.007" spread="1.0958"/>
                    <measurement group_id="O5" value="0.292" spread="0.6240"/>
                    <measurement group_id="O6" value="-0.835" spread="1.6488"/>
                    <measurement group_id="O7" value="-0.142" spread="1.5163"/>
                    <measurement group_id="O8" value="0.327" spread="0.9991"/>
                    <measurement group_id="O9" value="-0.111" spread="0.7964"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, 24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.073" spread="0.3189"/>
                    <measurement group_id="O2" value="0.243" spread="0.1888"/>
                    <measurement group_id="O3" value="-0.248" spread="0.3124"/>
                    <measurement group_id="O4" value="-0.140" spread="0.2305"/>
                    <measurement group_id="O5" value="-0.188" spread="0.3172"/>
                    <measurement group_id="O6" value="-0.158" spread="0.1659"/>
                    <measurement group_id="O7" value="-0.124" spread="0.0727"/>
                    <measurement group_id="O8" value="-0.005" spread="0.2375"/>
                    <measurement group_id="O9" value="0.027" spread="0.2972"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, 48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.082" spread="0.3344"/>
                    <measurement group_id="O2" value="0.320" spread="0.2909"/>
                    <measurement group_id="O3" value="-0.244" spread="0.4865"/>
                    <measurement group_id="O4" value="-0.238" spread="0.2739"/>
                    <measurement group_id="O5" value="-0.050" spread="0.2748"/>
                    <measurement group_id="O6" value="-0.110" spread="0.2873"/>
                    <measurement group_id="O7" value="-0.303" spread="0.4113"/>
                    <measurement group_id="O8" value="0.082" spread="0.2490"/>
                    <measurement group_id="O9" value="0.164" spread="0.3759"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.142" spread="0.2643"/>
                    <measurement group_id="O2" value="0.207" spread="0.2388"/>
                    <measurement group_id="O3" value="-0.215" spread="0.3661"/>
                    <measurement group_id="O4" value="-0.035" spread="0.1747"/>
                    <measurement group_id="O5" value="0.000" spread="0.3509"/>
                    <measurement group_id="O6" value="-0.143" spread="0.1766"/>
                    <measurement group_id="O7" value="-0.093" spread="0.3449"/>
                    <measurement group_id="O8" value="0.285" spread="0.2741"/>
                    <measurement group_id="O9" value="0.181" spread="0.4474"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.027" spread="0.4607"/>
                    <measurement group_id="O2" value="0.082" spread="0.2491"/>
                    <measurement group_id="O3" value="-0.165" spread="0.6984"/>
                    <measurement group_id="O4" value="-0.012" spread="0.4303"/>
                    <measurement group_id="O5" value="-0.067" spread="0.4020"/>
                    <measurement group_id="O6" value="-0.097" spread="0.4866"/>
                    <measurement group_id="O7" value="-0.232" spread="0.3513"/>
                    <measurement group_id="O8" value="-0.130" spread="0.3107"/>
                    <measurement group_id="O9" value="0.005" spread="0.3483"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, 24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.017" spread="0.0755"/>
                    <measurement group_id="O2" value="0.040" spread="0.0846"/>
                    <measurement group_id="O3" value="-0.107" spread="0.1405"/>
                    <measurement group_id="O4" value="-0.045" spread="0.0505"/>
                    <measurement group_id="O5" value="-0.022" spread="0.1342"/>
                    <measurement group_id="O6" value="0.068" spread="0.2099"/>
                    <measurement group_id="O7" value="-0.042" spread="0.1252"/>
                    <measurement group_id="O8" value="0.028" spread="0.0643"/>
                    <measurement group_id="O9" value="-0.014" spread="0.0870"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, 48 hours, 6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.048" spread="0.1052"/>
                    <measurement group_id="O2" value="0.043" spread="0.1198"/>
                    <measurement group_id="O3" value="-0.104" spread="0.1146"/>
                    <measurement group_id="O4" value="-0.050" spread="0.0885"/>
                    <measurement group_id="O5" value="-0.002" spread="0.0854"/>
                    <measurement group_id="O6" value="0.083" spread="0.1533"/>
                    <measurement group_id="O7" value="0.083" spread="0.2224"/>
                    <measurement group_id="O8" value="0.037" spread="0.0441"/>
                    <measurement group_id="O9" value="0.002" spread="0.0795"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.015" spread="0.1266"/>
                    <measurement group_id="O2" value="0.082" spread="0.1219"/>
                    <measurement group_id="O3" value="-0.090" spread="0.1307"/>
                    <measurement group_id="O4" value="-0.047" spread="0.0579"/>
                    <measurement group_id="O5" value="-0.018" spread="0.1184"/>
                    <measurement group_id="O6" value="0.078" spread="0.1242"/>
                    <measurement group_id="O7" value="0.020" spread="0.1655"/>
                    <measurement group_id="O8" value="0.033" spread="0.0572"/>
                    <measurement group_id="O9" value="0.020" spread="0.0890"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes,FU (Day 15), n= 6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.003" spread="0.0771"/>
                    <measurement group_id="O2" value="0.048" spread="0.0826"/>
                    <measurement group_id="O3" value="-0.022" spread="0.1309"/>
                    <measurement group_id="O4" value="0.020" spread="0.1619"/>
                    <measurement group_id="O5" value="0.045" spread="0.0896"/>
                    <measurement group_id="O6" value="0.115" spread="0.0789"/>
                    <measurement group_id="O7" value="0.008" spread="0.1439"/>
                    <measurement group_id="O8" value="-0.003" spread="0.0855"/>
                    <measurement group_id="O9" value="-0.002" spread="0.0878"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, 24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.528" spread="0.5383"/>
                    <measurement group_id="O2" value="0.583" spread="0.6552"/>
                    <measurement group_id="O3" value="-0.562" spread="0.7714"/>
                    <measurement group_id="O4" value="0.230" spread="0.8517"/>
                    <measurement group_id="O5" value="0.342" spread="0.4796"/>
                    <measurement group_id="O6" value="-0.500" spread="2.0326"/>
                    <measurement group_id="O7" value="0.110" spread="0.2985"/>
                    <measurement group_id="O8" value="0.035" spread="0.6405"/>
                    <measurement group_id="O9" value="0.059" spread="0.7913"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, 48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.507" spread="0.8878"/>
                    <measurement group_id="O2" value="-0.003" spread="0.5852"/>
                    <measurement group_id="O3" value="-0.546" spread="0.6919"/>
                    <measurement group_id="O4" value="-0.007" spread="0.9485"/>
                    <measurement group_id="O5" value="0.342" spread="0.9186"/>
                    <measurement group_id="O6" value="-0.455" spread="1.6850"/>
                    <measurement group_id="O7" value="1.425" spread="2.7042"/>
                    <measurement group_id="O8" value="0.153" spread="0.5704"/>
                    <measurement group_id="O9" value="-0.085" spread="0.7056"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.587" spread="0.7991"/>
                    <measurement group_id="O2" value="0.628" spread="0.6082"/>
                    <measurement group_id="O3" value="-0.575" spread="0.6277"/>
                    <measurement group_id="O4" value="-0.027" spread="0.9432"/>
                    <measurement group_id="O5" value="0.513" spread="0.9082"/>
                    <measurement group_id="O6" value="-0.218" spread="2.3225"/>
                    <measurement group_id="O7" value="0.440" spread="1.1395"/>
                    <measurement group_id="O8" value="0.218" spread="0.4922"/>
                    <measurement group_id="O9" value="0.055" spread="0.6401"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, FU (Day 15), n= 6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.398" spread="0.6349"/>
                    <measurement group_id="O2" value="0.345" spread="0.9399"/>
                    <measurement group_id="O3" value="0.077" spread="1.0609"/>
                    <measurement group_id="O4" value="-0.037" spread="0.9710"/>
                    <measurement group_id="O5" value="0.302" spread="0.6797"/>
                    <measurement group_id="O6" value="-0.643" spread="1.4316"/>
                    <measurement group_id="O7" value="0.120" spread="1.1397"/>
                    <measurement group_id="O8" value="0.475" spread="0.7676"/>
                    <measurement group_id="O9" value="-0.107" spread="0.7009"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, 24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="11.40"/>
                    <measurement group_id="O2" value="9.7" spread="30.29"/>
                    <measurement group_id="O3" value="-8.5" spread="16.11"/>
                    <measurement group_id="O4" value="-17.5" spread="27.90"/>
                    <measurement group_id="O5" value="-2.8" spread="14.48"/>
                    <measurement group_id="O6" value="7.2" spread="9.54"/>
                    <measurement group_id="O7" value="-9.0" spread="37.33"/>
                    <measurement group_id="O8" value="-1.7" spread="31.17"/>
                    <measurement group_id="O9" value="-3.3" spread="34.99"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, 48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.5" spread="15.95"/>
                    <measurement group_id="O2" value="-3.2" spread="17.33"/>
                    <measurement group_id="O3" value="-11.0" spread="21.13"/>
                    <measurement group_id="O4" value="-1.7" spread="13.08"/>
                    <measurement group_id="O5" value="0.7" spread="14.98"/>
                    <measurement group_id="O6" value="9.5" spread="11.64"/>
                    <measurement group_id="O7" value="-14.7" spread="36.62"/>
                    <measurement group_id="O8" value="-2.8" spread="18.97"/>
                    <measurement group_id="O9" value="0.8" spread="22.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-8.2" spread="15.75"/>
                    <measurement group_id="O2" value="7.3" spread="14.65"/>
                    <measurement group_id="O3" value="-6.8" spread="14.99"/>
                    <measurement group_id="O4" value="1.3" spread="17.29"/>
                    <measurement group_id="O5" value="2.3" spread="24.57"/>
                    <measurement group_id="O6" value="6.7" spread="15.02"/>
                    <measurement group_id="O7" value="-13.2" spread="44.37"/>
                    <measurement group_id="O8" value="0.3" spread="24.34"/>
                    <measurement group_id="O9" value="-1.7" spread="22.98"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-10.4" spread="21.59"/>
                    <measurement group_id="O2" value="19.2" spread="14.66"/>
                    <measurement group_id="O3" value="-16.7" spread="36.59"/>
                    <measurement group_id="O4" value="13.0" spread="15.85"/>
                    <measurement group_id="O5" value="6.5" spread="22.64"/>
                    <measurement group_id="O6" value="13.0" spread="29.48"/>
                    <measurement group_id="O7" value="-13.0" spread="48.17"/>
                    <measurement group_id="O8" value="-4.0" spread="18.64"/>
                    <measurement group_id="O9" value="-1.6" spread="32.94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Hematology Parameters: Erythrocytes.</title>
        <description>Blood samples were collected to analyze the hematology parameters: erythrocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Hematology Parameters: Erythrocytes.</title>
          <description>Blood samples were collected to analyze the hematology parameters: erythrocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>10^12 cells/Liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.118" spread="0.2576"/>
                    <measurement group_id="O2" value="0.338" spread="0.1150"/>
                    <measurement group_id="O3" value="-0.005" spread="0.1747"/>
                    <measurement group_id="O4" value="0.147" spread="0.2925"/>
                    <measurement group_id="O5" value="0.212" spread="0.2335"/>
                    <measurement group_id="O6" value="0.198" spread="0.0933"/>
                    <measurement group_id="O7" value="0.084" spread="0.1928"/>
                    <measurement group_id="O8" value="0.302" spread="0.1447"/>
                    <measurement group_id="O9" value="0.197" spread="0.2148"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.162" spread="0.2899"/>
                    <measurement group_id="O2" value="0.142" spread="0.1607"/>
                    <measurement group_id="O3" value="-0.024" spread="0.2501"/>
                    <measurement group_id="O4" value="0.108" spread="0.3252"/>
                    <measurement group_id="O5" value="0.152" spread="0.1528"/>
                    <measurement group_id="O6" value="0.288" spread="0.1082"/>
                    <measurement group_id="O7" value="0.087" spread="0.2295"/>
                    <measurement group_id="O8" value="0.180" spread="0.2440"/>
                    <measurement group_id="O9" value="0.171" spread="0.2112"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.155" spread="0.2290"/>
                    <measurement group_id="O2" value="0.202" spread="0.1683"/>
                    <measurement group_id="O3" value="0.083" spread="0.2499"/>
                    <measurement group_id="O4" value="0.178" spread="0.2320"/>
                    <measurement group_id="O5" value="-0.035" spread="0.2672"/>
                    <measurement group_id="O6" value="0.112" spread="0.0674"/>
                    <measurement group_id="O7" value="0.062" spread="0.2528"/>
                    <measurement group_id="O8" value="0.237" spread="0.2530"/>
                    <measurement group_id="O9" value="0.189" spread="0.1834"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Follow Up (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.027" spread="0.1876"/>
                    <measurement group_id="O2" value="0.145" spread="0.2041"/>
                    <measurement group_id="O3" value="-0.060" spread="0.3138"/>
                    <measurement group_id="O4" value="0.023" spread="0.3370"/>
                    <measurement group_id="O5" value="-0.205" spread="0.1639"/>
                    <measurement group_id="O6" value="0.053" spread="0.1549"/>
                    <measurement group_id="O7" value="-0.295" spread="0.2001"/>
                    <measurement group_id="O8" value="0.007" spread="0.2067"/>
                    <measurement group_id="O9" value="0.032" spread="0.2691"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Hematology Parameters: Erythrocytes Mean Corpuscular Volume (Erythrocyte MCV).</title>
        <description>Blood samples were collected to analyze the hematology parameters: erythrocyte MCV. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Hematology Parameters: Erythrocytes Mean Corpuscular Volume (Erythrocyte MCV).</title>
          <description>Blood samples were collected to analyze the hematology parameters: erythrocyte MCV. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>Femtoliter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>24 hour, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.50" spread="1.390"/>
                    <measurement group_id="O2" value="-0.03" spread="0.497"/>
                    <measurement group_id="O3" value="0.17" spread="0.689"/>
                    <measurement group_id="O4" value="0.70" spread="0.494"/>
                    <measurement group_id="O5" value="-1.07" spread="0.575"/>
                    <measurement group_id="O6" value="-0.28" spread="1.192"/>
                    <measurement group_id="O7" value="-0.64" spread="0.754"/>
                    <measurement group_id="O8" value="-0.25" spread="0.853"/>
                    <measurement group_id="O9" value="0.05" spread="0.797"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hour, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.42" spread="0.966"/>
                    <measurement group_id="O2" value="0.35" spread="1.231"/>
                    <measurement group_id="O3" value="0.06" spread="0.673"/>
                    <measurement group_id="O4" value="0.13" spread="0.659"/>
                    <measurement group_id="O5" value="-0.57" spread="0.843"/>
                    <measurement group_id="O6" value="0.10" spread="1.135"/>
                    <measurement group_id="O7" value="-1.18" spread="0.703"/>
                    <measurement group_id="O8" value="-0.18" spread="0.725"/>
                    <measurement group_id="O9" value="0.24" spread="0.932"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hour,n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.75" spread="0.619"/>
                    <measurement group_id="O2" value="0.43" spread="0.950"/>
                    <measurement group_id="O3" value="0.02" spread="0.979"/>
                    <measurement group_id="O4" value="-0.22" spread="1.030"/>
                    <measurement group_id="O5" value="-0.85" spread="1.214"/>
                    <measurement group_id="O6" value="0.28" spread="1.177"/>
                    <measurement group_id="O7" value="-0.15" spread="0.616"/>
                    <measurement group_id="O8" value="-0.13" spread="0.388"/>
                    <measurement group_id="O9" value="0.20" spread="1.196"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Follow up (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.15" spread="1.263"/>
                    <measurement group_id="O2" value="1.83" spread="0.505"/>
                    <measurement group_id="O3" value="0.53" spread="0.850"/>
                    <measurement group_id="O4" value="-0.20" spread="1.241"/>
                    <measurement group_id="O5" value="-0.15" spread="1.253"/>
                    <measurement group_id="O6" value="0.42" spread="1.339"/>
                    <measurement group_id="O7" value="-0.10" spread="1.567"/>
                    <measurement group_id="O8" value="-0.28" spread="0.840"/>
                    <measurement group_id="O9" value="0.14" spread="1.153"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Hematology Parameter: Erythrocytes Mean Corpuscular Hemoglobin (Erythrocyte MCH)</title>
        <description>Blood samples were collected to analyze the hematology parameter: Erythrocyte MCH. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Hematology Parameter: Erythrocytes Mean Corpuscular Hemoglobin (Erythrocyte MCH)</title>
          <description>Blood samples were collected to analyze the hematology parameter: Erythrocyte MCH. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>Picograms</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.12" spread="0.337"/>
                    <measurement group_id="O2" value="0.18" spread="0.147"/>
                    <measurement group_id="O3" value="0.00" spread="0.438"/>
                    <measurement group_id="O4" value="-0.15" spread="0.596"/>
                    <measurement group_id="O5" value="0.25" spread="0.485"/>
                    <measurement group_id="O6" value="0.15" spread="0.339"/>
                    <measurement group_id="O7" value="0.08" spread="0.963"/>
                    <measurement group_id="O8" value="-0.07" spread="0.700"/>
                    <measurement group_id="O9" value="0.01" spread="0.635"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.15" spread="0.464"/>
                    <measurement group_id="O2" value="0.08" spread="0.271"/>
                    <measurement group_id="O3" value="0.14" spread="0.321"/>
                    <measurement group_id="O4" value="0.37" spread="0.779"/>
                    <measurement group_id="O5" value="0.73" spread="0.450"/>
                    <measurement group_id="O6" value="-0.18" spread="0.397"/>
                    <measurement group_id="O7" value="-0.03" spread="0.821"/>
                    <measurement group_id="O8" value="0.13" spread="0.446"/>
                    <measurement group_id="O9" value="0.18" spread="0.583"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hours,n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.47" spread="0.339"/>
                    <measurement group_id="O2" value="0.02" spread="0.194"/>
                    <measurement group_id="O3" value="-0.33" spread="0.301"/>
                    <measurement group_id="O4" value="0.17" spread="1.111"/>
                    <measurement group_id="O5" value="0.63" spread="0.589"/>
                    <measurement group_id="O6" value="-0.02" spread="0.319"/>
                    <measurement group_id="O7" value="-0.13" spread="0.459"/>
                    <measurement group_id="O8" value="-0.13" spread="0.497"/>
                    <measurement group_id="O9" value="0.17" spread="0.442"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Follow up, Day 15,n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.07" spread="0.266"/>
                    <measurement group_id="O2" value="-0.27" spread="0.459"/>
                    <measurement group_id="O3" value="0.35" spread="0.660"/>
                    <measurement group_id="O4" value="0.03" spread="0.665"/>
                    <measurement group_id="O5" value="0.92" spread="0.741"/>
                    <measurement group_id="O6" value="-0.40" spread="0.514"/>
                    <measurement group_id="O7" value="-0.03" spread="0.207"/>
                    <measurement group_id="O8" value="0.02" spread="0.319"/>
                    <measurement group_id="O9" value="0.03" spread="0.639"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Hematology Parameter: Hematocrit</title>
        <description>Blood samples were collected to analyze the hematology parameter: hematocrit. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Hematology Parameter: Hematocrit</title>
          <description>Blood samples were collected to analyze the hematology parameter: hematocrit. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>Percentage of red blood cells in blood</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0080" spread="0.02666"/>
                    <measurement group_id="O2" value="0.0288" spread="0.01150"/>
                    <measurement group_id="O3" value="0.0003" spread="0.01791"/>
                    <measurement group_id="O4" value="0.0163" spread="0.02526"/>
                    <measurement group_id="O5" value="0.0128" spread="0.02031"/>
                    <measurement group_id="O6" value="0.0155" spread="0.01058"/>
                    <measurement group_id="O7" value="0.0038" spread="0.01333"/>
                    <measurement group_id="O8" value="0.0250" spread="0.01416"/>
                    <measurement group_id="O9" value="0.0174" spread="0.0174"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0123" spread="0.02767"/>
                    <measurement group_id="O2" value="0.0143" spread="0.01521"/>
                    <measurement group_id="O3" value="-0.0018" spread="0.02255"/>
                    <measurement group_id="O4" value="0.0102" spread="0.02851"/>
                    <measurement group_id="O5" value="0.0103" spread="0.01256"/>
                    <measurement group_id="O6" value="0.0252" spread="0.00970"/>
                    <measurement group_id="O7" value="0.0013" spread="0.01739"/>
                    <measurement group_id="O8" value="0.0148" spread="0.02179"/>
                    <measurement group_id="O9" value="0.0163" spread="0.0163"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hours,n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0223" spread="0.01896"/>
                    <measurement group_id="O2" value="0.0198" spread="0.01771"/>
                    <measurement group_id="O3" value="0.0078" spread="0.02337"/>
                    <measurement group_id="O4" value="0.0145" spread="0.02346"/>
                    <measurement group_id="O5" value="-0.0072" spread="0.02753"/>
                    <measurement group_id="O6" value="0.0108" spread="0.00947"/>
                    <measurement group_id="O7" value="0.0045" spread="0.02345"/>
                    <measurement group_id="O8" value="0.0200" spread="0.02265"/>
                    <measurement group_id="O9" value="0.0177" spread="0.0177"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Follow up (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0032" spread="0.02247"/>
                    <measurement group_id="O2" value="0.0222" spread="0.01879"/>
                    <measurement group_id="O3" value="-0.0025" spread="0.02848"/>
                    <measurement group_id="O4" value="0.0012" spread="0.03201"/>
                    <measurement group_id="O5" value="-0.0185" spread="0.01816"/>
                    <measurement group_id="O6" value="0.0070" spread="0.01534"/>
                    <measurement group_id="O7" value="-0.0265" spread="0.01852"/>
                    <measurement group_id="O8" value="-0.0007" spread="0.01945"/>
                    <measurement group_id="O9" value="0.0035" spread="0.02603"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Hematology Parameter: Percentage of Reticulocytes</title>
        <description>Blood samples were collected to analyze the hematology parameter: percentage of reticulocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Hematology Parameter: Percentage of Reticulocytes</title>
          <description>Blood samples were collected to analyze the hematology parameter: percentage of reticulocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>10^12 cells per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00050" spread="0.001390"/>
                    <measurement group_id="O2" value="0.00055" spread="0.001608"/>
                    <measurement group_id="O3" value="0.00118" spread="0.001955"/>
                    <measurement group_id="O4" value="-0.00023" spread="0.002223"/>
                    <measurement group_id="O5" value="0.00022" spread="0.001694"/>
                    <measurement group_id="O6" value="-0.00015" spread="0.001276"/>
                    <measurement group_id="O7" value="0.00156" spread="0.002490"/>
                    <measurement group_id="O8" value="0.00057" spread="0.000579"/>
                    <measurement group_id="O9" value="0.00071" spread="0.001808"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00082" spread="0.001496"/>
                    <measurement group_id="O2" value="0.00123" spread="0.001334"/>
                    <measurement group_id="O3" value="0.00154" spread="0.001790"/>
                    <measurement group_id="O4" value="-0.00017" spread="0.002028"/>
                    <measurement group_id="O5" value="0.00070" spread="0.001451"/>
                    <measurement group_id="O6" value="0.00075" spread="0.001838"/>
                    <measurement group_id="O7" value="0.00260" spread="0.002924"/>
                    <measurement group_id="O8" value="0.00117" spread="0.001859"/>
                    <measurement group_id="O9" value="0.00118" spread="0.002221"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hours,n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.00005" spread="0.002040"/>
                    <measurement group_id="O2" value="0.00160" spread="0.001615"/>
                    <measurement group_id="O3" value="0.00095" spread="0.002517"/>
                    <measurement group_id="O4" value="0.00023" spread="0.001965"/>
                    <measurement group_id="O5" value="0.00138" spread="0.001841"/>
                    <measurement group_id="O6" value="0.00060" spread="0.001663"/>
                    <measurement group_id="O7" value="0.00265" spread="0.002867"/>
                    <measurement group_id="O8" value="0.00175" spread="0.002019"/>
                    <measurement group_id="O9" value="0.00162" spread="0.002889"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Follow up (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.00018" spread="0.001273"/>
                    <measurement group_id="O2" value="0.00435" spread="0.001628"/>
                    <measurement group_id="O3" value="-0.00077" spread="0.002293"/>
                    <measurement group_id="O4" value="-0.00042" spread="0.002832"/>
                    <measurement group_id="O5" value="0.00092" spread="0.002495"/>
                    <measurement group_id="O6" value="-0.00015" spread="0.001640"/>
                    <measurement group_id="O7" value="-0.00002" spread="0.001841"/>
                    <measurement group_id="O8" value="0.00055" spread="0.002230"/>
                    <measurement group_id="O9" value="0.00061" spread="0.003329"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Hematology Parameter: Hemoglobin (Hb)</title>
        <description>Blood samples were collected to analyze the hematology parameter: Hb. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Hematology Parameter: Hemoglobin (Hb)</title>
          <description>Blood samples were collected to analyze the hematology parameter: Hb. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Grams per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>24 hours, n=6,6,6,6,6,6,5,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="5"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.2" spread="8.93"/>
                    <measurement group_id="O2" value="10.8" spread="3.43"/>
                    <measurement group_id="O3" value="0.0" spread="5.51"/>
                    <measurement group_id="O4" value="3.5" spread="7.34"/>
                    <measurement group_id="O5" value="7.7" spread="5.82"/>
                    <measurement group_id="O6" value="6.8" spread="1.72"/>
                    <measurement group_id="O7" value="3.0" spread="6.04"/>
                    <measurement group_id="O8" value="8.8" spread="7.91"/>
                    <measurement group_id="O9" value="5.9" spread="7.29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hours, n=6,6,5,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="5"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.7" spread="10.65"/>
                    <measurement group_id="O2" value="4.7" spread="5.89"/>
                    <measurement group_id="O3" value="0.0" spread="6.60"/>
                    <measurement group_id="O4" value="5.2" spread="6.88"/>
                    <measurement group_id="O5" value="8.3" spread="3.20"/>
                    <measurement group_id="O6" value="7.7" spread="3.72"/>
                    <measurement group_id="O7" value="2.5" spread="6.35"/>
                    <measurement group_id="O8" value="6.2" spread="7.88"/>
                    <measurement group_id="O9" value="6.0" spread="7.85"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.8" spread="6.27"/>
                    <measurement group_id="O2" value="6.0" spread="5.33"/>
                    <measurement group_id="O3" value="0.8" spread="6.49"/>
                    <measurement group_id="O4" value="6.3" spread="7.00"/>
                    <measurement group_id="O5" value="2.3" spread="7.97"/>
                    <measurement group_id="O6" value="3.2" spread="2.71"/>
                    <measurement group_id="O7" value="1.2" spread="9.13"/>
                    <measurement group_id="O8" value="6.5" spread="9.67"/>
                    <measurement group_id="O9" value="6.6" spread="5.51"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Follow up (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.5" spread="5.75"/>
                    <measurement group_id="O2" value="3.0" spread="7.24"/>
                    <measurement group_id="O3" value="0.0" spread="11.05"/>
                    <measurement group_id="O4" value="1.0" spread="7.97"/>
                    <measurement group_id="O5" value="-1.5" spread="7.06"/>
                    <measurement group_id="O6" value="-0.5" spread="3.39"/>
                    <measurement group_id="O7" value="-9.2" spread="6.82"/>
                    <measurement group_id="O8" value="0.2" spread="6.37"/>
                    <measurement group_id="O9" value="1.0" spread="8.25"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Clinical Chemistry Parameter: Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphate (ALP)</title>
        <description>Blood samples were collected to analyze the chemistry parameter: ALT, AST, and ALP. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Clinical Chemistry Parameter: Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphate (ALP)</title>
          <description>Blood samples were collected to analyze the chemistry parameter: ALT, AST, and ALP. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>International units per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>ALT, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.7" spread="4.55"/>
                    <measurement group_id="O2" value="0.3" spread="3.39"/>
                    <measurement group_id="O3" value="0.8" spread="3.60"/>
                    <measurement group_id="O4" value="-3.8" spread="2.04"/>
                    <measurement group_id="O5" value="-0.5" spread="4.93"/>
                    <measurement group_id="O6" value="-3.8" spread="3.49"/>
                    <measurement group_id="O7" value="0.0" spread="5.44"/>
                    <measurement group_id="O8" value="-0.3" spread="5.05"/>
                    <measurement group_id="O9" value="-0.8" spread="4.68"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.5" spread="5.75"/>
                    <measurement group_id="O2" value="-0.2" spread="4.49"/>
                    <measurement group_id="O3" value="0.3" spread="4.37"/>
                    <measurement group_id="O4" value="1.2" spread="2.23"/>
                    <measurement group_id="O5" value="0.5" spread="4.04"/>
                    <measurement group_id="O6" value="-2.7" spread="6.25"/>
                    <measurement group_id="O7" value="-2.7" spread="4.89"/>
                    <measurement group_id="O8" value="5.0" spread="10.17"/>
                    <measurement group_id="O9" value="-0.1" spread="4.94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.5" spread="5.01"/>
                    <measurement group_id="O2" value="4.0" spread="3.90"/>
                    <measurement group_id="O3" value="1.3" spread="4.68"/>
                    <measurement group_id="O4" value="2.2" spread="3.19"/>
                    <measurement group_id="O5" value="2.5" spread="5.47"/>
                    <measurement group_id="O6" value="-3.5" spread="8.26"/>
                    <measurement group_id="O7" value="0.5" spread="4.85"/>
                    <measurement group_id="O8" value="3.8" spread="10.76"/>
                    <measurement group_id="O9" value="2.5" spread="8.08"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="10.01"/>
                    <measurement group_id="O2" value="2.3" spread="4.32"/>
                    <measurement group_id="O3" value="2.3" spread="3.56"/>
                    <measurement group_id="O4" value="9.5" spread="14.46"/>
                    <measurement group_id="O5" value="5.2" spread="9.95"/>
                    <measurement group_id="O6" value="0.3" spread="14.35"/>
                    <measurement group_id="O7" value="1.0" spread="4.34"/>
                    <measurement group_id="O8" value="5.3" spread="6.06"/>
                    <measurement group_id="O9" value="5.1" spread="15.95"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-5.7" spread="7.63"/>
                    <measurement group_id="O2" value="-0.4" spread="3.13"/>
                    <measurement group_id="O3" value="-2.5" spread="2.88"/>
                    <measurement group_id="O4" value="-4.2" spread="1.94"/>
                    <measurement group_id="O5" value="-3.5" spread="4.72"/>
                    <measurement group_id="O6" value="-4.7" spread="6.74"/>
                    <measurement group_id="O7" value="-0.7" spread="3.72"/>
                    <measurement group_id="O8" value="-1.3" spread="2.94"/>
                    <measurement group_id="O9" value="-3.0" spread="3.60"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-4.3" spread="7.50"/>
                    <measurement group_id="O2" value="-2.3" spread="3.83"/>
                    <measurement group_id="O3" value="-3.0" spread="2.10"/>
                    <measurement group_id="O4" value="-2.2" spread="1.72"/>
                    <measurement group_id="O5" value="-0.7" spread="4.80"/>
                    <measurement group_id="O6" value="-2.5" spread="3.33"/>
                    <measurement group_id="O7" value="-2.0" spread="3.85"/>
                    <measurement group_id="O8" value="1.4" spread="5.86"/>
                    <measurement group_id="O9" value="-2.6" spread="4.11"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-4.2" spread="8.57"/>
                    <measurement group_id="O2" value="-1.7" spread="3.20"/>
                    <measurement group_id="O3" value="-4.2" spread="3.97"/>
                    <measurement group_id="O4" value="-1.3" spread="2.73"/>
                    <measurement group_id="O5" value="-3.3" spread="4.89"/>
                    <measurement group_id="O6" value="-4.5" spread="4.85"/>
                    <measurement group_id="O7" value="-1.8" spread="4.31"/>
                    <measurement group_id="O8" value="-1.5" spread="4.89"/>
                    <measurement group_id="O9" value="-1.4" spread="3.48"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.5" spread="8.53"/>
                    <measurement group_id="O2" value="4.5" spread="9.57"/>
                    <measurement group_id="O3" value="1.0" spread="5.18"/>
                    <measurement group_id="O4" value="-0.5" spread="2.88"/>
                    <measurement group_id="O5" value="4.5" spread="5.36"/>
                    <measurement group_id="O6" value="-1.7" spread="2.80"/>
                    <measurement group_id="O7" value="2.2" spread="8.26"/>
                    <measurement group_id="O8" value="0.9" spread="5.87"/>
                    <measurement group_id="O9" value="0.9" spread="5.87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.8" spread="4.54"/>
                    <measurement group_id="O2" value="6.0" spread="3.74"/>
                    <measurement group_id="O3" value="1.2" spread="8.28"/>
                    <measurement group_id="O4" value="-1.0" spread="6.66"/>
                    <measurement group_id="O5" value="-2.8" spread="6.15"/>
                    <measurement group_id="O6" value="-1.2" spread="8.42"/>
                    <measurement group_id="O7" value="-0.2" spread="4.67"/>
                    <measurement group_id="O8" value="0.7" spread="3.78"/>
                    <measurement group_id="O9" value="-2.9" spread="4.10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="4.93"/>
                    <measurement group_id="O2" value="1.7" spread="5.13"/>
                    <measurement group_id="O3" value="2.2" spread="6.24"/>
                    <measurement group_id="O4" value="-0.8" spread="5.31"/>
                    <measurement group_id="O5" value="-1.7" spread="6.65"/>
                    <measurement group_id="O6" value="-1.5" spread="8.29"/>
                    <measurement group_id="O7" value="-0.8" spread="5.31"/>
                    <measurement group_id="O8" value="0.6" spread="2.97"/>
                    <measurement group_id="O9" value="-2.4" spread="4.84"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="4.18"/>
                    <measurement group_id="O2" value="5.2" spread="2.93"/>
                    <measurement group_id="O3" value="3.5" spread="10.09"/>
                    <measurement group_id="O4" value="0.0" spread="5.18"/>
                    <measurement group_id="O5" value="0.5" spread="4.85"/>
                    <measurement group_id="O6" value="-4.8" spread="9.11"/>
                    <measurement group_id="O7" value="1.5" spread="6.19"/>
                    <measurement group_id="O8" value="1.2" spread="3.49"/>
                    <measurement group_id="O9" value="-1.1" spread="4.16"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.3" spread="1.37"/>
                    <measurement group_id="O2" value="1.5" spread="3.27"/>
                    <measurement group_id="O3" value="-0.5" spread="4.81"/>
                    <measurement group_id="O4" value="2.2" spread="6.62"/>
                    <measurement group_id="O5" value="-1.2" spread="6.97"/>
                    <measurement group_id="O6" value="-1.8" spread="6.01"/>
                    <measurement group_id="O7" value="-0.8" spread="5.98"/>
                    <measurement group_id="O8" value="-0.3" spread="1.97"/>
                    <measurement group_id="O9" value="-0.4" spread="6.37"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Clinical Chemistry Parameters : Bicarbonate, Calcium, Chloride, Magnesium, Phosphate, Potassium, Sodium, Urea</title>
        <description>Blood samples were collected to analyze the chemistry parameter: bicarbonate, calcium, chloride, magnesium, phosphate, potassium, sodium, urea. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Clinical Chemistry Parameters : Bicarbonate, Calcium, Chloride, Magnesium, Phosphate, Potassium, Sodium, Urea</title>
          <description>Blood samples were collected to analyze the chemistry parameter: bicarbonate, calcium, chloride, magnesium, phosphate, potassium, sodium, urea. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Millimoles per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Bicarbonate, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="1.86"/>
                    <measurement group_id="O2" value="3.0" spread="3.03"/>
                    <measurement group_id="O3" value="-3.2" spread="3.06"/>
                    <measurement group_id="O4" value="2.2" spread="2.04"/>
                    <measurement group_id="O5" value="-0.2" spread="2.14"/>
                    <measurement group_id="O6" value="0.5" spread="1.76"/>
                    <measurement group_id="O7" value="-2.2" spread="1.47"/>
                    <measurement group_id="O8" value="0.0" spread="1.67"/>
                    <measurement group_id="O9" value="0.8" spread="2.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.3" spread="1.86"/>
                    <measurement group_id="O2" value="3.5" spread="2.66"/>
                    <measurement group_id="O3" value="-1.3" spread="2.42"/>
                    <measurement group_id="O4" value="2.7" spread="1.86"/>
                    <measurement group_id="O5" value="2.2" spread="1.94"/>
                    <measurement group_id="O6" value="5.8" spread="3.71"/>
                    <measurement group_id="O7" value="-0.5" spread="1.38"/>
                    <measurement group_id="O8" value="-1.8" spread="1.64"/>
                    <measurement group_id="O9" value="2.1" spread="3.57"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.2" spread="1.72"/>
                    <measurement group_id="O2" value="2.0" spread="3.41"/>
                    <measurement group_id="O3" value="-2.0" spread="2.76"/>
                    <measurement group_id="O4" value="1.3" spread="2.50"/>
                    <measurement group_id="O5" value="-1.2" spread="4.31"/>
                    <measurement group_id="O6" value="0.8" spread="1.94"/>
                    <measurement group_id="O7" value="-2.2" spread="2.04"/>
                    <measurement group_id="O8" value="-2.2" spread="2.32"/>
                    <measurement group_id="O9" value="1.1" spread="2.47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate,FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.2" spread="1.47"/>
                    <measurement group_id="O2" value="1.5" spread="1.05"/>
                    <measurement group_id="O3" value="-1.8" spread="2.64"/>
                    <measurement group_id="O4" value="1.7" spread="1.75"/>
                    <measurement group_id="O5" value="1.2" spread="1.94"/>
                    <measurement group_id="O6" value="1.2" spread="2.93"/>
                    <measurement group_id="O7" value="-0.3" spread="2.88"/>
                    <measurement group_id="O8" value="-0.8" spread="1.47"/>
                    <measurement group_id="O9" value="1.1" spread="1.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.045" spread="0.0931"/>
                    <measurement group_id="O2" value="0.038" spread="0.0627"/>
                    <measurement group_id="O3" value="-0.037" spread="0.0866"/>
                    <measurement group_id="O4" value="-0.033" spread="0.0987"/>
                    <measurement group_id="O5" value="-0.012" spread="0.0492"/>
                    <measurement group_id="O6" value="0.060" spread="0.0562"/>
                    <measurement group_id="O7" value="0.035" spread="0.0731"/>
                    <measurement group_id="O8" value="0.002" spread="0.0454"/>
                    <measurement group_id="O9" value="0.005" spread="0.0647"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.047" spread="0.0997"/>
                    <measurement group_id="O2" value="0.042" spread="0.0581"/>
                    <measurement group_id="O3" value="-0.032" spread="0.0731"/>
                    <measurement group_id="O4" value="-0.008" spread="0.0808"/>
                    <measurement group_id="O5" value="0.008" spread="0.0736"/>
                    <measurement group_id="O6" value="0.145" spread="0.0568"/>
                    <measurement group_id="O7" value="-0.017" spread="0.0476"/>
                    <measurement group_id="O8" value="-0.018" spread="0.0349"/>
                    <measurement group_id="O9" value="0.031" spread="0.0762"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.005" spread="0.0909"/>
                    <measurement group_id="O2" value="0.070" spread="0.0687"/>
                    <measurement group_id="O3" value="-0.012" spread="0.0838"/>
                    <measurement group_id="O4" value="0.027" spread="0.0747"/>
                    <measurement group_id="O5" value="-0.015" spread="0.0680"/>
                    <measurement group_id="O6" value="0.097" spread="0.0625"/>
                    <measurement group_id="O7" value="0.025" spread="0.0497"/>
                    <measurement group_id="O8" value="-0.045" spread="0.0836"/>
                    <measurement group_id="O9" value="0.034" spread="0.0687"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.003" spread="0.0686"/>
                    <measurement group_id="O2" value="0.060" spread="0.0620"/>
                    <measurement group_id="O3" value="0.008" spread="0.1194"/>
                    <measurement group_id="O4" value="0.003" spread="0.0709"/>
                    <measurement group_id="O5" value="-0.047" spread="0.0528"/>
                    <measurement group_id="O6" value="0.043" spread="0.0753"/>
                    <measurement group_id="O7" value="-0.017" spread="0.1134"/>
                    <measurement group_id="O8" value="-0.027" spread="0.0455"/>
                    <measurement group_id="O9" value="0.033" spread="0.0694"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="1.47"/>
                    <measurement group_id="O2" value="-2.2" spread="2.04"/>
                    <measurement group_id="O3" value="2.7" spread="2.07"/>
                    <measurement group_id="O4" value="-0.5" spread="1.87"/>
                    <measurement group_id="O5" value="0.2" spread="3.06"/>
                    <measurement group_id="O6" value="0.5" spread="2.66"/>
                    <measurement group_id="O7" value="-0.7" spread="2.16"/>
                    <measurement group_id="O8" value="0.3" spread="2.73"/>
                    <measurement group_id="O9" value="0.6" spread="2.00"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="1.47"/>
                    <measurement group_id="O2" value="-0.8" spread="1.47"/>
                    <measurement group_id="O3" value="2.3" spread="1.63"/>
                    <measurement group_id="O4" value="-2.0" spread="1.90"/>
                    <measurement group_id="O5" value="-0.2" spread="2.32"/>
                    <measurement group_id="O6" value="0.7" spread="3.08"/>
                    <measurement group_id="O7" value="-0.7" spread="2.73"/>
                    <measurement group_id="O8" value="0.6" spread="1.95"/>
                    <measurement group_id="O9" value="0.5" spread="1.75"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.7" spread="1.21"/>
                    <measurement group_id="O2" value="-1.2" spread="2.99"/>
                    <measurement group_id="O3" value="1.0" spread="2.00"/>
                    <measurement group_id="O4" value="0.0" spread="1.79"/>
                    <measurement group_id="O5" value="-0.5" spread="2.88"/>
                    <measurement group_id="O6" value="0.3" spread="2.94"/>
                    <measurement group_id="O7" value="0.7" spread="2.16"/>
                    <measurement group_id="O8" value="-1.3" spread="1.97"/>
                    <measurement group_id="O9" value="0.1" spread="2.76"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="1.37"/>
                    <measurement group_id="O2" value="-0.3" spread="2.25"/>
                    <measurement group_id="O3" value="0.5" spread="1.64"/>
                    <measurement group_id="O4" value="-0.3" spread="2.07"/>
                    <measurement group_id="O5" value="1.3" spread="3.39"/>
                    <measurement group_id="O6" value="0.8" spread="2.48"/>
                    <measurement group_id="O7" value="0.8" spread="2.48"/>
                    <measurement group_id="O8" value="-0.7" spread="3.27"/>
                    <measurement group_id="O9" value="-0.6" spread="1.75"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.018" spread="0.0483"/>
                    <measurement group_id="O2" value="-0.017" spread="0.0350"/>
                    <measurement group_id="O3" value="0.023" spread="0.0393"/>
                    <measurement group_id="O4" value="0.023" spread="0.0398"/>
                    <measurement group_id="O5" value="0.003" spread="0.0393"/>
                    <measurement group_id="O6" value="0.033" spread="0.0398"/>
                    <measurement group_id="O7" value="0.003" spread="0.0339"/>
                    <measurement group_id="O8" value="0.012" spread="0.0560"/>
                    <measurement group_id="O9" value="0.014" spread="0.0495"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.043" spread="0.0983"/>
                    <measurement group_id="O2" value="0.005" spread="0.0513"/>
                    <measurement group_id="O3" value="0.035" spread="0.0468"/>
                    <measurement group_id="O4" value="0.012" spread="0.0349"/>
                    <measurement group_id="O5" value="0.017" spread="0.0476"/>
                    <measurement group_id="O6" value="0.060" spread="0.0369"/>
                    <measurement group_id="O7" value="0.025" spread="0.0459"/>
                    <measurement group_id="O8" value="0.034" spread="0.0513"/>
                    <measurement group_id="O9" value="0.034" spread="0.0626"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.010" spread="0.0525"/>
                    <measurement group_id="O2" value="0.022" spread="0.0488"/>
                    <measurement group_id="O3" value="0.037" spread="0.0535"/>
                    <measurement group_id="O4" value="0.015" spread="0.0568"/>
                    <measurement group_id="O5" value="0.002" spread="0.0264"/>
                    <measurement group_id="O6" value="0.048" spread="0.0204"/>
                    <measurement group_id="O7" value="0.033" spread="0.0308"/>
                    <measurement group_id="O8" value="0.007" spread="0.0476"/>
                    <measurement group_id="O9" value="0.042" spread="0.0507"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.008" spread="0.0643"/>
                    <measurement group_id="O2" value="-0.035" spread="0.0367"/>
                    <measurement group_id="O3" value="-0.020" spread="0.0583"/>
                    <measurement group_id="O4" value="0.010" spread="0.0502"/>
                    <measurement group_id="O5" value="-0.017" spread="0.0361"/>
                    <measurement group_id="O6" value="0.017" spread="0.0367"/>
                    <measurement group_id="O7" value="0.013" spread="0.0550"/>
                    <measurement group_id="O8" value="-0.015" spread="0.0468"/>
                    <measurement group_id="O9" value="0.002" spread="0.0489"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.088" spread="0.1074"/>
                    <measurement group_id="O2" value="0.117" spread="0.1777"/>
                    <measurement group_id="O3" value="0.098" spread="0.1843"/>
                    <measurement group_id="O4" value="-0.080" spread="0.1370"/>
                    <measurement group_id="O5" value="-0.003" spread="0.1279"/>
                    <measurement group_id="O6" value="-0.010" spread="0.1803"/>
                    <measurement group_id="O7" value="0.032" spread="0.1647"/>
                    <measurement group_id="O8" value="-0.018" spread="0.0968"/>
                    <measurement group_id="O9" value="0.020" spread="0.1363"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.148" spread="0.0679"/>
                    <measurement group_id="O2" value="-0.022" spread="0.1713"/>
                    <measurement group_id="O3" value="0.107" spread="0.1540"/>
                    <measurement group_id="O4" value="-0.063" spread="0.1528"/>
                    <measurement group_id="O5" value="-0.043" spread="0.1499"/>
                    <measurement group_id="O6" value="-0.058" spread="0.1816"/>
                    <measurement group_id="O7" value="0.025" spread="0.1801"/>
                    <measurement group_id="O8" value="-0.076" spread="0.0963"/>
                    <measurement group_id="O9" value="0.022" spread="0.1561"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.077" spread="0.1084"/>
                    <measurement group_id="O2" value="0.122" spread="0.1854"/>
                    <measurement group_id="O3" value="0.098" spread="0.1485"/>
                    <measurement group_id="O4" value="-0.055" spread="0.1934"/>
                    <measurement group_id="O5" value="-0.028" spread="0.0995"/>
                    <measurement group_id="O6" value="-0.027" spread="0.1645"/>
                    <measurement group_id="O7" value="0.092" spread="0.1240"/>
                    <measurement group_id="O8" value="0.042" spread="0.1144"/>
                    <measurement group_id="O9" value="0.029" spread="0.1391"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.107" spread="0.1224"/>
                    <measurement group_id="O2" value="-0.018" spread="0.1230"/>
                    <measurement group_id="O3" value="0.1230" spread="0.1378"/>
                    <measurement group_id="O4" value="-0.090" spread="0.1485"/>
                    <measurement group_id="O5" value="0.042" spread="0.1865"/>
                    <measurement group_id="O6" value="-0.055" spread="0.1407"/>
                    <measurement group_id="O7" value="0.063" spread="0.1138"/>
                    <measurement group_id="O8" value="0.002" spread="0.1341"/>
                    <measurement group_id="O9" value="-0.022" spread="0.1285"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.03" spread="0.647"/>
                    <measurement group_id="O2" value="0.42" spread="0.313"/>
                    <measurement group_id="O3" value="0.33" spread="0.327"/>
                    <measurement group_id="O4" value="0.20" spread="0.290"/>
                    <measurement group_id="O5" value="0.20" spread="0.276"/>
                    <measurement group_id="O6" value="0.22" spread="0.313"/>
                    <measurement group_id="O7" value="0.10" spread="0.245"/>
                    <measurement group_id="O8" value="-0.05" spread="0.423"/>
                    <measurement group_id="O9" value="0.25" spread="0.316"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.28" spread="0.417"/>
                    <measurement group_id="O2" value="0.30" spread="0.310"/>
                    <measurement group_id="O3" value="0.25" spread="0.217"/>
                    <measurement group_id="O4" value="0.07" spread="0.258"/>
                    <measurement group_id="O5" value="0.20" spread="0.253"/>
                    <measurement group_id="O6" value="0.30" spread="0.228"/>
                    <measurement group_id="O7" value="0.07" spread="0.163"/>
                    <measurement group_id="O8" value="0.06" spread="0.251"/>
                    <measurement group_id="O9" value="0.16" spread="0.278"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00" spread="0.525"/>
                    <measurement group_id="O2" value="0.30" spread="0.335"/>
                    <measurement group_id="O3" value="0.38" spread="0.306"/>
                    <measurement group_id="O4" value="0.12" spread="0.232"/>
                    <measurement group_id="O5" value="0.20" spread="0.352"/>
                    <measurement group_id="O6" value="0.20" spread="0.316"/>
                    <measurement group_id="O7" value="0.08" spread="0.232"/>
                    <measurement group_id="O8" value="-0.12" spread="0.204"/>
                    <measurement group_id="O9" value="0.30" spread="0.314"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.12" spread="0.436"/>
                    <measurement group_id="O2" value="0.43" spread="0.413"/>
                    <measurement group_id="O3" value="-0.05" spread="0.207"/>
                    <measurement group_id="O4" value="-0.03" spread="0.356"/>
                    <measurement group_id="O5" value="0.07" spread="0.250"/>
                    <measurement group_id="O6" value="0.18" spread="0.183"/>
                    <measurement group_id="O7" value="0.05" spread="0.339"/>
                    <measurement group_id="O8" value="-0.27" spread="0.314"/>
                    <measurement group_id="O9" value="0.10" spread="0.379"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0" spread="1.26"/>
                    <measurement group_id="O2" value="0.0" spread="1.90"/>
                    <measurement group_id="O3" value="0.3" spread="2.16"/>
                    <measurement group_id="O4" value="-0.7" spread="1.63"/>
                    <measurement group_id="O5" value="-1.5" spread="0.55"/>
                    <measurement group_id="O6" value="-0.3" spread="2.42"/>
                    <measurement group_id="O7" value="-1.3" spread="1.21"/>
                    <measurement group_id="O8" value="0.5" spread="2.26"/>
                    <measurement group_id="O9" value="0.3" spread="1.95"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.0" spread="1.10"/>
                    <measurement group_id="O2" value="-0.2" spread="2.14"/>
                    <measurement group_id="O3" value="1.0" spread="1.67"/>
                    <measurement group_id="O4" value="-0.7" spread="1.37"/>
                    <measurement group_id="O5" value="-1.8" spread="1.60"/>
                    <measurement group_id="O6" value="1.2" spread="2.23"/>
                    <measurement group_id="O7" value="-1.3" spread="2.25"/>
                    <measurement group_id="O8" value="0.8" spread="1.92"/>
                    <measurement group_id="O9" value="0.8" spread="1.80"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.8" spread="1.47"/>
                    <measurement group_id="O2" value="0.5" spread="1.64"/>
                    <measurement group_id="O3" value="0.7" spread="1.21"/>
                    <measurement group_id="O4" value="1.3" spread="3.01"/>
                    <measurement group_id="O5" value="-1.7" spread="1.86"/>
                    <measurement group_id="O6" value="0.0" spread="0.20"/>
                    <measurement group_id="O7" value="0.8" spread="1.83"/>
                    <measurement group_id="O8" value="1.3" spread="1.03"/>
                    <measurement group_id="O9" value="0.5" spread="2.42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.8" spread="2.14"/>
                    <measurement group_id="O2" value="0.3" spread="2.07"/>
                    <measurement group_id="O3" value="-0.2" spread="1.47"/>
                    <measurement group_id="O4" value="-0.2" spread="1.47"/>
                    <measurement group_id="O5" value="0.8" spread="1.72"/>
                    <measurement group_id="O6" value="0.7" spread="2.07"/>
                    <measurement group_id="O7" value="0.5" spread="2.17"/>
                    <measurement group_id="O8" value="0.0" spread="2.19"/>
                    <measurement group_id="O9" value="0.4" spread="1.82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.033320" spread="0.3443425"/>
                    <measurement group_id="O2" value="0.283220" spread="1.0396160"/>
                    <measurement group_id="O3" value="0.299880" spread="0.6630596"/>
                    <measurement group_id="O4" value="-0.649740" spread="1.0517198"/>
                    <measurement group_id="O5" value="-0.166600" spread="0.8450414"/>
                    <measurement group_id="O6" value="-0.599760" spread="0.7717016"/>
                    <measurement group_id="O7" value="0.133280" spread="0.3880028"/>
                    <measurement group_id="O8" value="-0.849660" spread="1.3570283"/>
                    <measurement group_id="O9" value="-0.187425" spread="0.9102217"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.316540" spread="0.8081731"/>
                    <measurement group_id="O2" value="0.416500" spread="0.8769556"/>
                    <measurement group_id="O3" value="0.116620" spread="0.7701895"/>
                    <measurement group_id="O4" value="-0.683060" spread="1.0103710"/>
                    <measurement group_id="O5" value="-0.233240" spread="0.9601712"/>
                    <measurement group_id="O6" value="-0.316540" spread="0.6366649"/>
                    <measurement group_id="O7" value="0.083300" spread="0.7108180"/>
                    <measurement group_id="O8" value="-1.099560" spread="0.8242913"/>
                    <measurement group_id="O9" value="-0.187425" spread="1.0590572"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.116620" spread="0.7274909"/>
                    <measurement group_id="O2" value="0.233240" spread="0.9476011"/>
                    <measurement group_id="O3" value="0.316540" spread="1.0510863"/>
                    <measurement group_id="O4" value="-0.733040" spread="1.1736967"/>
                    <measurement group_id="O5" value="-0.433160" spread="0.5986483"/>
                    <measurement group_id="O6" value="0.049980" spread="0.5955804"/>
                    <measurement group_id="O7" value="0.166600" spread="0.9241120"/>
                    <measurement group_id="O8" value="-0.916300" spread="1.5178348"/>
                    <measurement group_id="O9" value="0.046648" spread="1.2598057"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea,FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.483140" spread="0.9491815"/>
                    <measurement group_id="O2" value="0.466480" spread="0.9929136"/>
                    <measurement group_id="O3" value="0.466480" spread="0.3828177"/>
                    <measurement group_id="O4" value="-0.499800" spread="0.5930586"/>
                    <measurement group_id="O5" value="-0.233240" spread="2.0187631"/>
                    <measurement group_id="O6" value="-0.649740" spread="0.7173480"/>
                    <measurement group_id="O7" value="-0.033320" spread="1.0907403"/>
                    <measurement group_id="O8" value="-1.332800" spread="1.4230410"/>
                    <measurement group_id="O9" value="-0.099960" spread="0.6590288"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Cholesterol, Glucose, High Density Lipoprotein (HDL) Cholesterol, Low Density Cholesterol (LDL) Cholesterol, Triglycerides</title>
        <description>Blood samples were collected to analyze the chemistry parameter: cholesterol, glucose, HDL cholesterol, LDL cholesterol, triglycerides. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2) and Day 1 (96 hours) and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Cholesterol, Glucose, High Density Lipoprotein (HDL) Cholesterol, Low Density Cholesterol (LDL) Cholesterol, Triglycerides</title>
          <description>Blood samples were collected to analyze the chemistry parameter: cholesterol, glucose, HDL cholesterol, LDL cholesterol, triglycerides. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>Millimoles per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Cholesterol,Day1,96 hours,n=5,6,6,6,5,6,6,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="5"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.40" spread="0.324"/>
                    <measurement group_id="O2" value="0.32" spread="0.271"/>
                    <measurement group_id="O3" value="-0.05" spread="0.628"/>
                    <measurement group_id="O4" value="0.02" spread="0.422"/>
                    <measurement group_id="O5" value="-0.06" spread="0.699"/>
                    <measurement group_id="O6" value="0.13" spread="0.516"/>
                    <measurement group_id="O7" value="0.45" spread="0.373"/>
                    <measurement group_id="O8" value="0.43" spread="0.641"/>
                    <measurement group_id="O9" value="0.30" spread="0.445"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Cholesterol, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.25" spread="0.404"/>
                    <measurement group_id="O2" value="0.23" spread="0.327"/>
                    <measurement group_id="O3" value="0.07" spread="0.579"/>
                    <measurement group_id="O4" value="0.23" spread="0.493"/>
                    <measurement group_id="O5" value="-0.16" spread="0.590"/>
                    <measurement group_id="O6" value="-0.40" spread="0.562"/>
                    <measurement group_id="O7" value="0.08" spread="0.445"/>
                    <measurement group_id="O8" value="0.22" spread="0.496"/>
                    <measurement group_id="O9" value="0.16" spread="0.566"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>HDL cholesterol,Day1,96 hours,n=6,6,6,6,5,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="5"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.02" spread="0.041"/>
                    <measurement group_id="O2" value="-0.05" spread="0.105"/>
                    <measurement group_id="O3" value="-0.15" spread="0.152"/>
                    <measurement group_id="O4" value="-0.12" spread="0.147"/>
                    <measurement group_id="O5" value="-0.22" spread="0.084"/>
                    <measurement group_id="O6" value="-0.12" spread="0.098"/>
                    <measurement group_id="O7" value="-0.02" spread="0.133"/>
                    <measurement group_id="O8" value="-0.13" spread="0.103"/>
                    <measurement group_id="O9" value="-0.08" spread="0.174"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>HDL cholesterol, FU (Day 15), n=6,6,6,6,5,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="5"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.07" spread="0.137"/>
                    <measurement group_id="O2" value="-0.05" spread="0.122"/>
                    <measurement group_id="O3" value="-0.02" spread="0.160"/>
                    <measurement group_id="O4" value="0.00" spread="0.179"/>
                    <measurement group_id="O5" value="-0.18" spread="0.148"/>
                    <measurement group_id="O6" value="-0.05" spread="0.105"/>
                    <measurement group_id="O7" value="-0.02" spread="0.264"/>
                    <measurement group_id="O8" value="-0.03" spread="0.103"/>
                    <measurement group_id="O9" value="0.00" spread="0.219"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>LDL cholesterol,Day1, 96hours,n=5,6,6,6,5,6,6,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="5"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.30" spread="0.122"/>
                    <measurement group_id="O2" value="0.10" spread="0.562"/>
                    <measurement group_id="O3" value="-0.12" spread="0.519"/>
                    <measurement group_id="O4" value="-0.13" spread="0.408"/>
                    <measurement group_id="O5" value="-0.04" spread="0.428"/>
                    <measurement group_id="O6" value="-0.03" spread="0.361"/>
                    <measurement group_id="O7" value="0.43" spread="0.441"/>
                    <measurement group_id="O8" value="0.25" spread="0.281"/>
                    <measurement group_id="O9" value="0.16" spread="0.386"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>LDL cholesterol, FU(Day 15), n=6,6,6,6,5,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="5"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.30" spread="0.210"/>
                    <measurement group_id="O2" value="0.15" spread="0.295"/>
                    <measurement group_id="O3" value="0.22" spread="0.564"/>
                    <measurement group_id="O4" value="0.07" spread="0.314"/>
                    <measurement group_id="O5" value="-0.14" spread="0.472"/>
                    <measurement group_id="O6" value="-0.35" spread="0.451"/>
                    <measurement group_id="O7" value="0.37" spread="0.308"/>
                    <measurement group_id="O8" value="0.07" spread="0.327"/>
                    <measurement group_id="O9" value="0.13" spread="0.491"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Triglycerides,Day1,96 hours,n=5,6,6,6,5,6,6,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="5"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.28" spread="0.531"/>
                    <measurement group_id="O2" value="0.60" spread="1.079"/>
                    <measurement group_id="O3" value="0.45" spread="0.468"/>
                    <measurement group_id="O4" value="0.62" spread="1.026"/>
                    <measurement group_id="O5" value="0.52" spread="0.931"/>
                    <measurement group_id="O6" value="0.60" spread="0.883"/>
                    <measurement group_id="O7" value="0.03" spread="0.468"/>
                    <measurement group_id="O8" value="0.70" spread="0.834"/>
                    <measurement group_id="O9" value="0.49" spread="0.360"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Triglycerides, FU (Day 15),n=6,6,6,6,5,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="5"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.20" spread="0.297"/>
                    <measurement group_id="O2" value="0.32" spread="0.838"/>
                    <measurement group_id="O3" value="-0.30" spread="0.303"/>
                    <measurement group_id="O4" value="0.40" spread="0.940"/>
                    <measurement group_id="O5" value="0.40" spread="0.831"/>
                    <measurement group_id="O6" value="0.02" spread="0.279"/>
                    <measurement group_id="O7" value="-0.55" spread="0.501"/>
                    <measurement group_id="O8" value="0.40" spread="0.410"/>
                    <measurement group_id="O9" value="0.05" spread="0.588"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Chemistry Parameter: Glucose</title>
        <description>Blood samples were collected to analyze the chemistry parameter: glucose . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2) and Day 1 (96 hours) and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Chemistry Parameter: Glucose</title>
          <description>Blood samples were collected to analyze the chemistry parameter: glucose . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>Millimoles per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 1 (96 hours), n=5,6,6,6,6,6,6,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.16" spread="0.288"/>
                    <measurement group_id="O2" value="-0.30" spread="0.110"/>
                    <measurement group_id="O3" value="-0.25" spread="0.414"/>
                    <measurement group_id="O4" value="-0.28" spread="0.527"/>
                    <measurement group_id="O5" value="-0.17" spread="0.446"/>
                    <measurement group_id="O6" value="-0.08" spread="0.349"/>
                    <measurement group_id="O7" value="-0.07" spread="0.432"/>
                    <measurement group_id="O8" value="-0.33" spread="0.175"/>
                    <measurement group_id="O9" value="-0.21" spread="0.279"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.03" spread="0.513"/>
                    <measurement group_id="O2" value="-0.05" spread="0.345"/>
                    <measurement group_id="O3" value="-0.12" spread="0.605"/>
                    <measurement group_id="O4" value="-0.22" spread="0.471"/>
                    <measurement group_id="O5" value="0.07" spread="0.582"/>
                    <measurement group_id="O6" value="-0.27" spread="0.367"/>
                    <measurement group_id="O7" value="-0.27" spread="0.745"/>
                    <measurement group_id="O8" value="0.00" spread="0.374"/>
                    <measurement group_id="O9" value="-0.04" spread="0.379"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Clinical Chemistry Parameter: Bilirubin, Creatinine, Direct Bilirubin</title>
        <description>Blood samples were collected to analyze the chemistry parameter: bilirubin, creatinine, direct bilirubin . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Clinical Chemistry Parameter: Bilirubin, Creatinine, Direct Bilirubin</title>
          <description>Blood samples were collected to analyze the chemistry parameter: bilirubin, creatinine, direct bilirubin . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Grams per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Bilirubin, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.5" spread="2.88"/>
                    <measurement group_id="O2" value="-0.2" spread="3.37"/>
                    <measurement group_id="O3" value="-5.3" spread="3.33"/>
                    <measurement group_id="O4" value="-1.5" spread="5.32"/>
                    <measurement group_id="O5" value="0.2" spread="3.19"/>
                    <measurement group_id="O6" value="-1.7" spread="2.94"/>
                    <measurement group_id="O7" value="-2.5" spread="1.97"/>
                    <measurement group_id="O8" value="-0.3" spread="1.37"/>
                    <measurement group_id="O9" value="-1.2" spread="3.19"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.2" spread="3.19"/>
                    <measurement group_id="O2" value="-0.8" spread="4.26"/>
                    <measurement group_id="O3" value="-4.7" spread="3.20"/>
                    <measurement group_id="O4" value="-0.7" spread="4.13"/>
                    <measurement group_id="O5" value="0.3" spread="2.50"/>
                    <measurement group_id="O6" value="0.3" spread="1.51"/>
                    <measurement group_id="O7" value="-0.5" spread="2.35"/>
                    <measurement group_id="O8" value="-1.6" spread="2.07"/>
                    <measurement group_id="O9" value="-0.6" spread="2.97"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.2" spread="2.32"/>
                    <measurement group_id="O2" value="-2.5" spread="4.04"/>
                    <measurement group_id="O3" value="-3.8" spread="3.60"/>
                    <measurement group_id="O4" value="-1.3" spread="4.80"/>
                    <measurement group_id="O5" value="-1.7" spread="3.14"/>
                    <measurement group_id="O6" value="-0.2" spread="2.23"/>
                    <measurement group_id="O7" value="-2.2" spread="2.79"/>
                    <measurement group_id="O8" value="-1.05" spread="1.05"/>
                    <measurement group_id="O9" value="-0.6" spread="2.61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, FU (Day 15),n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.8" spread="3.43"/>
                    <measurement group_id="O2" value="3.3" spread="4.13"/>
                    <measurement group_id="O3" value="-0.8" spread="2.56"/>
                    <measurement group_id="O4" value="2.5" spread="2.88"/>
                    <measurement group_id="O5" value="1.0" spread="5.10"/>
                    <measurement group_id="O6" value="-1.0" spread="3.10"/>
                    <measurement group_id="O7" value="2.2" spread="4.92"/>
                    <measurement group_id="O8" value="2.0" spread="2.97"/>
                    <measurement group_id="O9" value="1.2" spread="4.20"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-7.0" spread="7.13"/>
                    <measurement group_id="O2" value="3.2" spread="5.85"/>
                    <measurement group_id="O3" value="-0.5" spread="3.62"/>
                    <measurement group_id="O4" value="0.2" spread="5.49"/>
                    <measurement group_id="O5" value="-1.2" spread="1.83"/>
                    <measurement group_id="O6" value="6.8" spread="4.62"/>
                    <measurement group_id="O7" value="-0.7" spread="6.12"/>
                    <measurement group_id="O8" value="-1.5" spread="9.03"/>
                    <measurement group_id="O9" value="0.6" spread="6.83"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-6.7" spread="7.15"/>
                    <measurement group_id="O2" value="7.2" spread="4.96"/>
                    <measurement group_id="O3" value="-1.2" spread="2.14"/>
                    <measurement group_id="O4" value="-3.8" spread="5.34"/>
                    <measurement group_id="O5" value="0.8" spread="4.92"/>
                    <measurement group_id="O6" value="6.5" spread="6.25"/>
                    <measurement group_id="O7" value="-1.7" spread="7.39"/>
                    <measurement group_id="O8" value="-2.8" spread="8.76"/>
                    <measurement group_id="O9" value="0.8" spread="6.69"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.5" spread="7.34"/>
                    <measurement group_id="O2" value="8.7" spread="4.89"/>
                    <measurement group_id="O3" value="3.2" spread="4.71"/>
                    <measurement group_id="O4" value="0.0" spread="5.33"/>
                    <measurement group_id="O5" value="0.0" spread="8.72"/>
                    <measurement group_id="O6" value="7.2" spread="4.36"/>
                    <measurement group_id="O7" value="-5.3" spread="6.44"/>
                    <measurement group_id="O8" value="-0.7" spread="5.47"/>
                    <measurement group_id="O9" value="4.6" spread="7.56"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.5" spread="6.38"/>
                    <measurement group_id="O2" value="9.3" spread="7.76"/>
                    <measurement group_id="O3" value="-1.3" spread="5.09"/>
                    <measurement group_id="O4" value="-1.7" spread="7.20"/>
                    <measurement group_id="O5" value="2.5" spread="4.97"/>
                    <measurement group_id="O6" value="3.0" spread="3.95"/>
                    <measurement group_id="O7" value="-0.8" spread="7.05"/>
                    <measurement group_id="O8" value="-11.2" spread="9.02"/>
                    <measurement group_id="O9" value="1.9" spread="6.69"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct bilirubin, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.0" spread="1.26"/>
                    <measurement group_id="O2" value="-0.5" spread="1.29"/>
                    <measurement group_id="O3" value="-1.2" spread="1.30"/>
                    <measurement group_id="O4" value="0.2" spread="1.48"/>
                    <measurement group_id="O5" value="-0.2" spread="1.10"/>
                    <measurement group_id="O6" value="-1.0" spread="0.71"/>
                    <measurement group_id="O7" value="-1.0" spread="0.63"/>
                    <measurement group_id="O8" value="-0.3" spread="0.82"/>
                    <measurement group_id="O9" value="-0.3" spread="1.23"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct bilirubin, 48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.0" spread="1.55"/>
                    <measurement group_id="O2" value="-0.8" spread="1.26"/>
                    <measurement group_id="O3" value="-1.2" spread="0.75"/>
                    <measurement group_id="O4" value="-0.3" spread="1.03"/>
                    <measurement group_id="O5" value="0.0" spread="0.71"/>
                    <measurement group_id="O6" value="-0.2" spread="0.45"/>
                    <measurement group_id="O7" value="-0.5" spread="0.55"/>
                    <measurement group_id="O8" value="-0.8" spread="0.96"/>
                    <measurement group_id="O9" value="-0.5" spread="1.10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct bilirubin, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.8" spread="1.48"/>
                    <measurement group_id="O2" value="-1.0" spread="1.15"/>
                    <measurement group_id="O3" value="-0.6" spread="1.14"/>
                    <measurement group_id="O4" value="-0.3" spread="1.37"/>
                    <measurement group_id="O5" value="-0.3" spread="0.50"/>
                    <measurement group_id="O6" value="-0.2" spread="0.84"/>
                    <measurement group_id="O7" value="-0.8" spread="0.45"/>
                    <measurement group_id="O8" value="-0.8" spread="0.50"/>
                    <measurement group_id="O9" value="-0.3" spread="0.90"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct bilirubin, FU (Day 15),n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.7" spread="1.21"/>
                    <measurement group_id="O2" value="1.0" spread="1.22"/>
                    <measurement group_id="O3" value="0.2" spread="0.75"/>
                    <measurement group_id="O4" value="1.0" spread="0.89"/>
                    <measurement group_id="O5" value="0.8" spread="0.96"/>
                    <measurement group_id="O6" value="0.0" spread="1.41"/>
                    <measurement group_id="O7" value="0.5" spread="1.52"/>
                    <measurement group_id="O8" value="0.7" spread="1.37"/>
                    <measurement group_id="O9" value="0.4" spread="1.36"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Clinical Chemistry Parameter: Protein</title>
        <description>Blood samples were collected to analyze the chemistry parameter: Protein. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
        <time_frame>Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Clinical Chemistry Parameter: Protein</title>
          <description>Blood samples were collected to analyze the chemistry parameter: Protein. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Grams per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="3.39"/>
                    <measurement group_id="O2" value="2.5" spread="0.84"/>
                    <measurement group_id="O3" value="-5.2" spread="3.76"/>
                    <measurement group_id="O4" value="-1.0" spread="3.16"/>
                    <measurement group_id="O5" value="-1.2" spread="1.72"/>
                    <measurement group_id="O6" value="0.7" spread="1.21"/>
                    <measurement group_id="O7" value="0.3" spread="2.73"/>
                    <measurement group_id="O8" value="2.3" spread="2.25"/>
                    <measurement group_id="O9" value="-0.8" spread="2.37"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hours, n=6,6,6,6,6,6,6,5,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="5"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="5.16"/>
                    <measurement group_id="O2" value="0.0" spread="1.26"/>
                    <measurement group_id="O3" value="-4.0" spread="4.05"/>
                    <measurement group_id="O4" value="-2.3" spread="2.42"/>
                    <measurement group_id="O5" value="0.3" spread="1.51"/>
                    <measurement group_id="O6" value="2.2" spread="1.33"/>
                    <measurement group_id="O7" value="-0.3" spread="3.88"/>
                    <measurement group_id="O8" value="1.8" spread="2.28"/>
                    <measurement group_id="O9" value="0.2" spread="3.31"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.2" spread="3.60"/>
                    <measurement group_id="O2" value="1.5" spread="3.39"/>
                    <measurement group_id="O3" value="-2.0" spread="4.73"/>
                    <measurement group_id="O4" value="1.0" spread="4.10"/>
                    <measurement group_id="O5" value="-1.7" spread="5.20"/>
                    <measurement group_id="O6" value="0.8" spread="1.94"/>
                    <measurement group_id="O7" value="-0.3" spread="2.94"/>
                    <measurement group_id="O8" value="0.8" spread="3.60"/>
                    <measurement group_id="O9" value="1.3" spread="3.75"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 15),n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.5" spread="3.62"/>
                    <measurement group_id="O2" value="0.7" spread="2.25"/>
                    <measurement group_id="O3" value="-1.3" spread="6.31"/>
                    <measurement group_id="O4" value="0.2" spread="3.66"/>
                    <measurement group_id="O5" value="-2.7" spread="3.20"/>
                    <measurement group_id="O6" value="1.7" spread="2.42"/>
                    <measurement group_id="O7" value="-1.7" spread="3.98"/>
                    <measurement group_id="O8" value="1.7" spread="1.86"/>
                    <measurement group_id="O9" value="1.5" spread="3.85"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Number of Participants With Abnormal Urinalysis</title>
        <description>Urine samples were collected at given time points to analyze the abnormal findings for potential of hydrogen (pH), glucose, protein, blood, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase by dipstick.</description>
        <time_frame>Up to Day 15</time_frame>
        <population>Safety Population.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Number of Participants With Abnormal Urinalysis</title>
          <description>Urine samples were collected at given time points to analyze the abnormal findings for potential of hydrogen (pH), glucose, protein, blood, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase by dipstick.</description>
          <population>Safety Population.</population>
          <units>Participants</units>
          <param>Count of Participants</param>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Vital Signs: Diastolic Blood Pressure (DBP) and Systolic Blood Pressure (SBP)</title>
        <description>SBP and DBP were measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Vital Signs: Diastolic Blood Pressure (DBP) and Systolic Blood Pressure (SBP)</title>
          <description>SBP and DBP were measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Millimeters of mercury (mmHg)</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>SBP, 1 hour n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.5" spread="11.67"/>
                    <measurement group_id="O2" value="3.2" spread="4.45"/>
                    <measurement group_id="O3" value="6.3" spread="6.22"/>
                    <measurement group_id="O4" value="4.7" spread="6.77"/>
                    <measurement group_id="O5" value="6.2" spread="7.63"/>
                    <measurement group_id="O6" value="2.2" spread="11.07"/>
                    <measurement group_id="O7" value="5.8" spread="10.57"/>
                    <measurement group_id="O8" value="3.5" spread="4.93"/>
                    <measurement group_id="O9" value="8.1" spread="7.25"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, 2 hours n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.7" spread="7.84"/>
                    <measurement group_id="O2" value="2.2" spread="4.17"/>
                    <measurement group_id="O3" value="8.8" spread="3.06"/>
                    <measurement group_id="O4" value="10.7" spread="6.62"/>
                    <measurement group_id="O5" value="0.5" spread="7.50"/>
                    <measurement group_id="O6" value="5.5" spread="8.46"/>
                    <measurement group_id="O7" value="5.7" spread="14.02"/>
                    <measurement group_id="O8" value="6.2" spread="6.11"/>
                    <measurement group_id="O9" value="4.4" spread="8.05"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, 4.5 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="7.22"/>
                    <measurement group_id="O2" value="5.3" spread="5.20"/>
                    <measurement group_id="O3" value="8.8" spread="5.60"/>
                    <measurement group_id="O4" value="5.3" spread="6.12"/>
                    <measurement group_id="O5" value="6.7" spread="7.42"/>
                    <measurement group_id="O6" value="10.8" spread="9.81"/>
                    <measurement group_id="O7" value="8.7" spread="11.04"/>
                    <measurement group_id="O8" value="4.0" spread="6.84"/>
                    <measurement group_id="O9" value="7.4" spread="11.04"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, 6 hours n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.7" spread="5.75"/>
                    <measurement group_id="O2" value="4.7" spread="6.41"/>
                    <measurement group_id="O3" value="3.7" spread="4.63"/>
                    <measurement group_id="O4" value="9.5" spread="7.06"/>
                    <measurement group_id="O5" value="2.8" spread="7.73"/>
                    <measurement group_id="O6" value="4.0" spread="10.47"/>
                    <measurement group_id="O7" value="5.8" spread="12.81"/>
                    <measurement group_id="O8" value="6.5" spread="6.09"/>
                    <measurement group_id="O9" value="8.3" spread="10.97"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, 12 hours n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.8" spread="6.24"/>
                    <measurement group_id="O2" value="8.7" spread="6.77"/>
                    <measurement group_id="O3" value="10.2" spread="5.04"/>
                    <measurement group_id="O4" value="8.2" spread="6.62"/>
                    <measurement group_id="O5" value="2.5" spread="8.29"/>
                    <measurement group_id="O6" value="3.3" spread="7.23"/>
                    <measurement group_id="O7" value="2.5" spread="17.62"/>
                    <measurement group_id="O8" value="6.3" spread="3.39"/>
                    <measurement group_id="O9" value="7.6" spread="7.90"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, 24 hours n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.5" spread="5.54"/>
                    <measurement group_id="O2" value="3.2" spread="2.79"/>
                    <measurement group_id="O3" value="9.0" spread="6.32"/>
                    <measurement group_id="O4" value="3.3" spread="7.58"/>
                    <measurement group_id="O5" value="-0.3" spread="4.46"/>
                    <measurement group_id="O6" value="2.7" spread="5.72"/>
                    <measurement group_id="O7" value="5.8" spread="8.30"/>
                    <measurement group_id="O8" value="0.8" spread="7.57"/>
                    <measurement group_id="O9" value="5.1" spread="10.68"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, 48 hours n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-4.3" spread="6.59"/>
                    <measurement group_id="O2" value="1.3" spread="5.35"/>
                    <measurement group_id="O3" value="2.5" spread="8.22"/>
                    <measurement group_id="O4" value="0.3" spread="9.79"/>
                    <measurement group_id="O5" value="2.0" spread="11.45"/>
                    <measurement group_id="O6" value="-0.5" spread="7.50"/>
                    <measurement group_id="O7" value="2.5" spread="6.98"/>
                    <measurement group_id="O8" value="2.2" spread="9.24"/>
                    <measurement group_id="O9" value="1.0" spread="8.68"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP,72 hours n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.0" spread="5.66"/>
                    <measurement group_id="O2" value="2.0" spread="7.24"/>
                    <measurement group_id="O3" value="-0.8" spread="5.49"/>
                    <measurement group_id="O4" value="2.2" spread="8.52"/>
                    <measurement group_id="O5" value="-3.0" spread="6.57"/>
                    <measurement group_id="O6" value="1.0" spread="6.00"/>
                    <measurement group_id="O7" value="2.5" spread="11.93"/>
                    <measurement group_id="O8" value="3.0" spread="12.02"/>
                    <measurement group_id="O9" value="2.4" spread="6.13"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, 96 hours n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="5.42"/>
                    <measurement group_id="O2" value="1.3" spread="5.35"/>
                    <measurement group_id="O3" value="6.0" spread="11.40"/>
                    <measurement group_id="O4" value="5.3" spread="12.71"/>
                    <measurement group_id="O5" value="3.0" spread="5.80"/>
                    <measurement group_id="O6" value="6.3" spread="7.53"/>
                    <measurement group_id="O7" value="2.5" spread="14.34"/>
                    <measurement group_id="O8" value="0.7" spread="6.19"/>
                    <measurement group_id="O9" value="4.5" spread="9.02"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, FU(Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.7" spread="9.18"/>
                    <measurement group_id="O2" value="1.0" spread="7.69"/>
                    <measurement group_id="O3" value="11.5" spread="7.92"/>
                    <measurement group_id="O4" value="6.8" spread="7.22"/>
                    <measurement group_id="O5" value="4.5" spread="10.21"/>
                    <measurement group_id="O6" value="4.5" spread="6.02"/>
                    <measurement group_id="O7" value="11.5" spread="3.33"/>
                    <measurement group_id="O8" value="7.8" spread="4.22"/>
                    <measurement group_id="O9" value="7.3" spread="10.20"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, 1 hour n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.2" spread="8.84"/>
                    <measurement group_id="O2" value="-3.7" spread="2.07"/>
                    <measurement group_id="O3" value="0.8" spread="6.18"/>
                    <measurement group_id="O4" value="-1.2" spread="5.53"/>
                    <measurement group_id="O5" value="-0.3" spread="4.32"/>
                    <measurement group_id="O6" value="-2.0" spread="4.56"/>
                    <measurement group_id="O7" value="1.3" spread="9.87"/>
                    <measurement group_id="O8" value="0.5" spread="2.88"/>
                    <measurement group_id="O9" value="0.3" spread="8.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, 2 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-7.5" spread="8.96"/>
                    <measurement group_id="O2" value="-1.3" spread="3.27"/>
                    <measurement group_id="O3" value="1.0" spread="4.24"/>
                    <measurement group_id="O4" value="-1.3" spread="6.83"/>
                    <measurement group_id="O5" value="-2.7" spread="3.08"/>
                    <measurement group_id="O6" value="-3.3" spread="3.93"/>
                    <measurement group_id="O7" value="1.0" spread="10.45"/>
                    <measurement group_id="O8" value="0.5" spread="2.35"/>
                    <measurement group_id="O9" value="0.5" spread="8.42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, 4.5 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-4.8" spread="6.91"/>
                    <measurement group_id="O2" value="2.3" spread="6.44"/>
                    <measurement group_id="O3" value="6.7" spread="6.77"/>
                    <measurement group_id="O4" value="1.7" spread="6.83"/>
                    <measurement group_id="O5" value="2.2" spread="3.06"/>
                    <measurement group_id="O6" value="1.5" spread="4.55"/>
                    <measurement group_id="O7" value="2.2" spread="6.31"/>
                    <measurement group_id="O8" value="6.3" spread="8.16"/>
                    <measurement group_id="O9" value="6.8" spread="10.10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, 6 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.5" spread="4.42"/>
                    <measurement group_id="O2" value="-3.7" spread="4.93"/>
                    <measurement group_id="O3" value="0.2" spread="5.71"/>
                    <measurement group_id="O4" value="2.0" spread="3.74"/>
                    <measurement group_id="O5" value="-2.2" spread="5.15"/>
                    <measurement group_id="O6" value="-2.0" spread="6.48"/>
                    <measurement group_id="O7" value="1.8" spread="9.15"/>
                    <measurement group_id="O8" value="3.2" spread="7.78"/>
                    <measurement group_id="O9" value="2.4" spread="9.76"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, 12 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.8" spread="8.23"/>
                    <measurement group_id="O2" value="0.3" spread="2.58"/>
                    <measurement group_id="O3" value="4.2" spread="3.76"/>
                    <measurement group_id="O4" value="4.3" spread="9.09"/>
                    <measurement group_id="O5" value="1.0" spread="5.10"/>
                    <measurement group_id="O6" value="1.0" spread="6.10"/>
                    <measurement group_id="O7" value="1.5" spread="12.61"/>
                    <measurement group_id="O8" value="5.3" spread="3.83"/>
                    <measurement group_id="O9" value="4.8" spread="7.64"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="3.01"/>
                    <measurement group_id="O2" value="-0.5" spread="3.78"/>
                    <measurement group_id="O3" value="4.7" spread="5.35"/>
                    <measurement group_id="O4" value="2.8" spread="7.44"/>
                    <measurement group_id="O5" value="0.0" spread="4.00"/>
                    <measurement group_id="O6" value="0.8" spread="5.56"/>
                    <measurement group_id="O7" value="6.2" spread="8.04"/>
                    <measurement group_id="O8" value="3.3" spread="4.63"/>
                    <measurement group_id="O9" value="3.7" spread="9.16"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, 48 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.0" spread="6.29"/>
                    <measurement group_id="O2" value="-1.7" spread="6.56"/>
                    <measurement group_id="O3" value="3.0" spread="5.29"/>
                    <measurement group_id="O4" value="-2.5" spread="7.56"/>
                    <measurement group_id="O5" value="3.7" spread="5.65"/>
                    <measurement group_id="O6" value="-1.3" spread="5.43"/>
                    <measurement group_id="O7" value="1.7" spread="8.71"/>
                    <measurement group_id="O8" value="1.0" spread="4.73"/>
                    <measurement group_id="O9" value="4.3" spread="8.90"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP,72 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.2" spread="6.08"/>
                    <measurement group_id="O2" value="0.0" spread="6.00"/>
                    <measurement group_id="O3" value="1.7" spread="7.17"/>
                    <measurement group_id="O4" value="1.0" spread="6.84"/>
                    <measurement group_id="O5" value="-0.5" spread="5.09"/>
                    <measurement group_id="O6" value="1.7" spread="2.73"/>
                    <measurement group_id="O7" value="2.3" spread="8.71"/>
                    <measurement group_id="O8" value="4.7" spread="6.56"/>
                    <measurement group_id="O9" value="4.3" spread="8.02"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, 96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.1" spread="6.59"/>
                    <measurement group_id="O2" value="1.0" spread="3.10"/>
                    <measurement group_id="O3" value="5.0" spread="6.69"/>
                    <measurement group_id="O4" value="2.5" spread="8.02"/>
                    <measurement group_id="O5" value="2.7" spread="3.78"/>
                    <measurement group_id="O6" value="2.3" spread="6.06"/>
                    <measurement group_id="O7" value="1.5" spread="12.63"/>
                    <measurement group_id="O8" value="-0.2" spread="5.42"/>
                    <measurement group_id="O9" value="4.0" spread="7.39"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, FU(Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="12.56"/>
                    <measurement group_id="O2" value="-4.5" spread="5.50"/>
                    <measurement group_id="O3" value="6.8" spread="4.88"/>
                    <measurement group_id="O4" value="1.7" spread="7.37"/>
                    <measurement group_id="O5" value="2.5" spread="6.19"/>
                    <measurement group_id="O6" value="3.7" spread="5.20"/>
                    <measurement group_id="O7" value="7.3" spread="3.83"/>
                    <measurement group_id="O8" value="7.3" spread="5.35"/>
                    <measurement group_id="O9" value="7.1" spread="9.92"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Vital Signs: Pulse Rate</title>
        <description>Pulse rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Vital Signs: Pulse Rate</title>
          <description>Pulse rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Beats per minute</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>1 hour n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="13.3" spread="6.71"/>
                    <measurement group_id="O2" value="5.2" spread="2.48"/>
                    <measurement group_id="O3" value="14.5" spread="4.04"/>
                    <measurement group_id="O4" value="13.7" spread="5.05"/>
                    <measurement group_id="O5" value="11.3" spread="4.80"/>
                    <measurement group_id="O6" value="7.5" spread="3.67"/>
                    <measurement group_id="O7" value="9.0" spread="3.85"/>
                    <measurement group_id="O8" value="7.0" spread="2.97"/>
                    <measurement group_id="O9" value="9.6" spread="6.97"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>2 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.3" spread="4.89"/>
                    <measurement group_id="O2" value="3.2" spread="4.96"/>
                    <measurement group_id="O3" value="6.8" spread="4.75"/>
                    <measurement group_id="O4" value="10.7" spread="9.09"/>
                    <measurement group_id="O5" value="12.8" spread="6.05"/>
                    <measurement group_id="O6" value="6.0" spread="3.22"/>
                    <measurement group_id="O7" value="7.0" spread="5.80"/>
                    <measurement group_id="O8" value="3.7" spread="9.65"/>
                    <measurement group_id="O9" value="8.2" spread="3.99"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>4.5 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.5" spread="6.72"/>
                    <measurement group_id="O2" value="2.0" spread="7.56"/>
                    <measurement group_id="O3" value="3.7" spread="1.97"/>
                    <measurement group_id="O4" value="5.8" spread="4.40"/>
                    <measurement group_id="O5" value="8.2" spread="11.97"/>
                    <measurement group_id="O6" value="5.5" spread="3.94"/>
                    <measurement group_id="O7" value="4.2" spread="8.08"/>
                    <measurement group_id="O8" value="6.2" spread="6.85"/>
                    <measurement group_id="O9" value="6.4" spread="5.94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>6 hours,n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="16.8" spread="7.41"/>
                    <measurement group_id="O2" value="7.7" spread="5.85"/>
                    <measurement group_id="O3" value="9.7" spread="3.98"/>
                    <measurement group_id="O4" value="11.3" spread="6.02"/>
                    <measurement group_id="O5" value="11.2" spread="6.65"/>
                    <measurement group_id="O6" value="7.7" spread="3.88"/>
                    <measurement group_id="O7" value="8.3" spread="4.72"/>
                    <measurement group_id="O8" value="8.0" spread="3.16"/>
                    <measurement group_id="O9" value="10.4" spread="6.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>12 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.2" spread="4.40"/>
                    <measurement group_id="O2" value="5.7" spread="7.55"/>
                    <measurement group_id="O3" value="11.8" spread="6.85"/>
                    <measurement group_id="O4" value="9.0" spread="5.83"/>
                    <measurement group_id="O5" value="11.0" spread="4.90"/>
                    <measurement group_id="O6" value="6.5" spread="8.96"/>
                    <measurement group_id="O7" value="8.0" spread="11.26"/>
                    <measurement group_id="O8" value="6.0" spread="7.51"/>
                    <measurement group_id="O9" value="7.3" spread="5.61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.2" spread="4.58"/>
                    <measurement group_id="O2" value="3.3" spread="4.37"/>
                    <measurement group_id="O3" value="2.3" spread="6.56"/>
                    <measurement group_id="O4" value="4.5" spread="9.48"/>
                    <measurement group_id="O5" value="6.7" spread="10.15"/>
                    <measurement group_id="O6" value="2.5" spread="5.68"/>
                    <measurement group_id="O7" value="5.8" spread="10.38"/>
                    <measurement group_id="O8" value="1.0" spread="4.86"/>
                    <measurement group_id="O9" value="0.2" spread="3.89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.8" spread="5.67"/>
                    <measurement group_id="O2" value="3.5" spread="7.31"/>
                    <measurement group_id="O3" value="3.2" spread="4.58"/>
                    <measurement group_id="O4" value="4.5" spread="6.89"/>
                    <measurement group_id="O5" value="4.8" spread="6.46"/>
                    <measurement group_id="O6" value="-2.3" spread="6.83"/>
                    <measurement group_id="O7" value="10.8" spread="15.89"/>
                    <measurement group_id="O8" value="1.5" spread="6.35"/>
                    <measurement group_id="O9" value="1.5" spread="3.88"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>72 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.0" spread="8.58"/>
                    <measurement group_id="O2" value="3.8" spread="5.00"/>
                    <measurement group_id="O3" value="2.8" spread="4.31"/>
                    <measurement group_id="O4" value="6.8" spread="4.49"/>
                    <measurement group_id="O5" value="2.0" spread="3.29"/>
                    <measurement group_id="O6" value="-0.3" spread="6.19"/>
                    <measurement group_id="O7" value="4.5" spread="6.28"/>
                    <measurement group_id="O8" value="-0.2" spread="7.14"/>
                    <measurement group_id="O9" value="1.4" spread="5.40"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12.5" spread="12.93"/>
                    <measurement group_id="O2" value="4.8" spread="4.83"/>
                    <measurement group_id="O3" value="4.8" spread="5.15"/>
                    <measurement group_id="O4" value="9.2" spread="6.88"/>
                    <measurement group_id="O5" value="5.7" spread="4.37"/>
                    <measurement group_id="O6" value="4.0" spread="2.45"/>
                    <measurement group_id="O7" value="2.8" spread="4.54"/>
                    <measurement group_id="O8" value="8.0" spread="4.47"/>
                    <measurement group_id="O9" value="2.5" spread="4.29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.2" spread="4.71"/>
                    <measurement group_id="O2" value="3.3" spread="8.07"/>
                    <measurement group_id="O3" value="3.2" spread="6.52"/>
                    <measurement group_id="O4" value="6.3" spread="10.07"/>
                    <measurement group_id="O5" value="3.5" spread="3.99"/>
                    <measurement group_id="O6" value="-0.7" spread="11.93"/>
                    <measurement group_id="O7" value="4.8" spread="6.97"/>
                    <measurement group_id="O8" value="6.3" spread="8.24"/>
                    <measurement group_id="O9" value="1.3" spread="5.74"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Vital Signs: Temperature</title>
        <description>Temperature was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Vital Signs: Temperature</title>
          <description>Temperature was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Degree Celsius</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>1 hour, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.33" spread="0.186"/>
                    <measurement group_id="O2" value="0.15" spread="0.378"/>
                    <measurement group_id="O3" value="0.03" spread="0.333"/>
                    <measurement group_id="O4" value="0.18" spread="0.376"/>
                    <measurement group_id="O5" value="0.10" spread="0.303"/>
                    <measurement group_id="O6" value="0.00" spread="0.245"/>
                    <measurement group_id="O7" value="0.28" spread="0.256"/>
                    <measurement group_id="O8" value="0.22" spread="0.407"/>
                    <measurement group_id="O9" value="0.19" spread="0.267"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>2 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.20" spread="0.237"/>
                    <measurement group_id="O2" value="0.00" spread="0.322"/>
                    <measurement group_id="O3" value="0.15" spread="0.378"/>
                    <measurement group_id="O4" value="0.28" spread="0.256"/>
                    <measurement group_id="O5" value="0.02" spread="0.256"/>
                    <measurement group_id="O6" value="0.27" spread="0.250"/>
                    <measurement group_id="O7" value="0.17" spread="0.388"/>
                    <measurement group_id="O8" value="0.52" spread="0.279"/>
                    <measurement group_id="O9" value="0.23" spread="0.322"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>4.5 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.35" spread="0.308"/>
                    <measurement group_id="O2" value="0.23" spread="0.356"/>
                    <measurement group_id="O3" value="0.03" spread="0.350"/>
                    <measurement group_id="O4" value="0.07" spread="0.280"/>
                    <measurement group_id="O5" value="0.12" spread="0.360"/>
                    <measurement group_id="O6" value="0.45" spread="0.321"/>
                    <measurement group_id="O7" value="0.33" spread="0.308"/>
                    <measurement group_id="O8" value="0.42" spread="0.426"/>
                    <measurement group_id="O9" value="0.22" spread="0.299"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>6 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.45" spread="0.274"/>
                    <measurement group_id="O2" value="0.27" spread="0.234"/>
                    <measurement group_id="O3" value="0.15" spread="0.339"/>
                    <measurement group_id="O4" value="0.42" spread="0.223"/>
                    <measurement group_id="O5" value="0.20" spread="0.210"/>
                    <measurement group_id="O6" value="0.45" spread="0.394"/>
                    <measurement group_id="O7" value="0.38" spread="0.264"/>
                    <measurement group_id="O8" value="0.75" spread="0.217"/>
                    <measurement group_id="O9" value="0.29" spread="0.390"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>12 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.30" spread="0.219"/>
                    <measurement group_id="O2" value="0.20" spread="0.261"/>
                    <measurement group_id="O3" value="0.17" spread="0.350"/>
                    <measurement group_id="O4" value="0.20" spread="0.283"/>
                    <measurement group_id="O5" value="0.27" spread="0.493"/>
                    <measurement group_id="O6" value="0.18" spread="0.426"/>
                    <measurement group_id="O7" value="0.07" spread="0.175"/>
                    <measurement group_id="O8" value="0.53" spread="0.398"/>
                    <measurement group_id="O9" value="0.12" spread="0.259"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.13" spread="0.266"/>
                    <measurement group_id="O2" value="0.10" spread="0.210"/>
                    <measurement group_id="O3" value="0.07" spread="0.175"/>
                    <measurement group_id="O4" value="0.05" spread="0.105"/>
                    <measurement group_id="O5" value="0.05" spread="0.596"/>
                    <measurement group_id="O6" value="0.10" spread="0.310"/>
                    <measurement group_id="O7" value="0.17" spread="0.103"/>
                    <measurement group_id="O8" value="0.23" spread="0.427"/>
                    <measurement group_id="O9" value="0.03" spread="0.244"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.03" spread="0.234"/>
                    <measurement group_id="O2" value="0.10" spread="0.460"/>
                    <measurement group_id="O3" value="-0.18" spread="0.214"/>
                    <measurement group_id="O4" value="0.07" spread="0.356"/>
                    <measurement group_id="O5" value="-0.17" spread="0.250"/>
                    <measurement group_id="O6" value="-0.03" spread="0.463"/>
                    <measurement group_id="O7" value="0.42" spread="0.694"/>
                    <measurement group_id="O8" value="0.27" spread="0.489"/>
                    <measurement group_id="O9" value="0.04" spread="0.301"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>72 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.10" spread="0.110"/>
                    <measurement group_id="O2" value="0.23" spread="0.427"/>
                    <measurement group_id="O3" value="0.00" spread="0.316"/>
                    <measurement group_id="O4" value="0.18" spread="0.306"/>
                    <measurement group_id="O5" value="-0.12" spread="0.488"/>
                    <measurement group_id="O6" value="0.17" spread="0.446"/>
                    <measurement group_id="O7" value="0.25" spread="0.217"/>
                    <measurement group_id="O8" value="0.15" spread="0.362"/>
                    <measurement group_id="O9" value="0.03" spread="0.317"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.02" spread="0.232"/>
                    <measurement group_id="O2" value="0.10" spread="0.255"/>
                    <measurement group_id="O3" value="0.12" spread="0.160"/>
                    <measurement group_id="O4" value="-0.18" spread="0.214"/>
                    <measurement group_id="O5" value="-0.17" spread="0.628"/>
                    <measurement group_id="O6" value="0.22" spread="0.402"/>
                    <measurement group_id="O7" value="0.17" spread="0.216"/>
                    <measurement group_id="O8" value="0.08" spread="0.240"/>
                    <measurement group_id="O9" value="-0.07" spread="0.313"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.05" spread="0.327"/>
                    <measurement group_id="O2" value="-0.03" spread="0.344"/>
                    <measurement group_id="O3" value="0.12" spread="0.331"/>
                    <measurement group_id="O4" value="0.00" spread="0.518"/>
                    <measurement group_id="O5" value="0.20" spread="0.506"/>
                    <measurement group_id="O6" value="0.13" spread="0.344"/>
                    <measurement group_id="O7" value="0.18" spread="0.293"/>
                    <measurement group_id="O8" value="0.47" spread="0.398"/>
                    <measurement group_id="O9" value="0.11" spread="0.344"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Vital Sign: Respiratory Rate</title>
        <description>Respiratory rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Vital Sign: Respiratory Rate</title>
          <description>Respiratory rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Breaths per minute</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>1 hour, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread="1.52"/>
                    <measurement group_id="O2" value="0.8" spread="2.14"/>
                    <measurement group_id="O3" value="-0.3" spread="1.97"/>
                    <measurement group_id="O4" value="1.0" spread="0.89"/>
                    <measurement group_id="O5" value="-1.0" spread="2.37"/>
                    <measurement group_id="O6" value="0.3" spread="1.51"/>
                    <measurement group_id="O7" value="0.5" spread="1.38"/>
                    <measurement group_id="O8" value="0.8" spread="2.04"/>
                    <measurement group_id="O9" value="0.1" spread="2.69"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>2 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.7" spread="1.51"/>
                    <measurement group_id="O2" value="1.3" spread="3.27"/>
                    <measurement group_id="O3" value="1.0" spread="2.19"/>
                    <measurement group_id="O4" value="0.7" spread="1.37"/>
                    <measurement group_id="O5" value="0.5" spread="1.38"/>
                    <measurement group_id="O6" value="0.8" spread="2.14"/>
                    <measurement group_id="O7" value="-0.5" spread="3.08"/>
                    <measurement group_id="O8" value="1.3" spread="2.25"/>
                    <measurement group_id="O9" value="0.3" spread="2.02"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>4.5 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="1.72"/>
                    <measurement group_id="O2" value="0.8" spread="3.31"/>
                    <measurement group_id="O3" value="1.7" spread="3.20"/>
                    <measurement group_id="O4" value="0.8" spread="1.33"/>
                    <measurement group_id="O5" value="0.3" spread="1.21"/>
                    <measurement group_id="O6" value="0.7" spread="1.63"/>
                    <measurement group_id="O7" value="1.0" spread="1.41"/>
                    <measurement group_id="O8" value="0.7" spread="2.16"/>
                    <measurement group_id="O9" value="1.9" spread="2.31"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>6 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="1.97"/>
                    <measurement group_id="O2" value="0.3" spread="2.34"/>
                    <measurement group_id="O3" value="-1.7" spread="1.86"/>
                    <measurement group_id="O4" value="2.3" spread="2.80"/>
                    <measurement group_id="O5" value="-0.2" spread="2.04"/>
                    <measurement group_id="O6" value="0.7" spread="2.73"/>
                    <measurement group_id="O7" value="0.5" spread="1.97"/>
                    <measurement group_id="O8" value="1.3" spread="1.75"/>
                    <measurement group_id="O9" value="1.0" spread="3.35"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>12 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.2" spread="2.14"/>
                    <measurement group_id="O2" value="2.8" spread="4.26"/>
                    <measurement group_id="O3" value="2.2" spread="4.36"/>
                    <measurement group_id="O4" value="2.7" spread="2.34"/>
                    <measurement group_id="O5" value="-1.7" spread="2.88"/>
                    <measurement group_id="O6" value="-0.2" spread="1.33"/>
                    <measurement group_id="O7" value="1.3" spread="2.34"/>
                    <measurement group_id="O8" value="1.0" spread="2.53"/>
                    <measurement group_id="O9" value="2.2" spread="2.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="1.51"/>
                    <measurement group_id="O2" value="-0.3" spread="1.03"/>
                    <measurement group_id="O3" value="0.7" spread="2.80"/>
                    <measurement group_id="O4" value="0.3" spread="2.80"/>
                    <measurement group_id="O5" value="-2.0" spread="1.67"/>
                    <measurement group_id="O6" value="1.0" spread="2.61"/>
                    <measurement group_id="O7" value="-0.2" spread="0.98"/>
                    <measurement group_id="O8" value="1.5" spread="2.07"/>
                    <measurement group_id="O9" value="0.9" spread="2.66"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>48 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="1.97"/>
                    <measurement group_id="O2" value="-0.2" spread="2.32"/>
                    <measurement group_id="O3" value="0.5" spread="3.08"/>
                    <measurement group_id="O4" value="1.2" spread="2.04"/>
                    <measurement group_id="O5" value="0.0" spread="1.26"/>
                    <measurement group_id="O6" value="1.7" spread="1.21"/>
                    <measurement group_id="O7" value="1.7" spread="1.37"/>
                    <measurement group_id="O8" value="0.3" spread="2.25"/>
                    <measurement group_id="O9" value="-0.3" spread="3.15"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>72 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.2" spread="1.47"/>
                    <measurement group_id="O2" value="0.0" spread="2.19"/>
                    <measurement group_id="O3" value="0.3" spread="2.58"/>
                    <measurement group_id="O4" value="0.7" spread="3.50"/>
                    <measurement group_id="O5" value="-0.5" spread="2.35"/>
                    <measurement group_id="O6" value="-0.3" spread="1.97"/>
                    <measurement group_id="O7" value="-1.5" spread="2.35"/>
                    <measurement group_id="O8" value="0.5" spread="4.14"/>
                    <measurement group_id="O9" value="-0.3" spread="2.73"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>96 hours, n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.3" spread="1.97"/>
                    <measurement group_id="O2" value="0.5" spread="2.07"/>
                    <measurement group_id="O3" value="0.0" spread="2.00"/>
                    <measurement group_id="O4" value="-1.0" spread="2.37"/>
                    <measurement group_id="O5" value="0.2" spread="4.02"/>
                    <measurement group_id="O6" value="0.0" spread="1.26"/>
                    <measurement group_id="O7" value="-1.0" spread="2.68"/>
                    <measurement group_id="O8" value="0.3" spread="2.58"/>
                    <measurement group_id="O9" value="0.3" spread="2.37"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 15), n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.2" spread="2.71"/>
                    <measurement group_id="O2" value="-0.8" spread="2.48"/>
                    <measurement group_id="O3" value="0.5" spread="3.27"/>
                    <measurement group_id="O4" value="0.0" spread="2.90"/>
                    <measurement group_id="O5" value="0.5" spread="2.43"/>
                    <measurement group_id="O6" value="-1.2" spread="2.64"/>
                    <measurement group_id="O7" value="-0.5" spread="1.87"/>
                    <measurement group_id="O8" value="1.2" spread="2.86"/>
                    <measurement group_id="O9" value="0.3" spread="2.74"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Number of Participants With Abnormal Electrocardiogram (ECG) Findings</title>
        <description>12-lead ECGs were measured in a semi-supine position using an automated ECG machine after approximately 5 minutes of rest for the participant. Abnormal findings were categorized as clinically significant (CS) and not clinically significant (NCS).</description>
        <time_frame>Baseline (Day 1 predose), 1,2,4,6,12,24,48,72,96 hours post dose and Follow up (Day 15)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O9">
            <title>Part 1: Single Dose Placebo</title>
            <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Number of Participants With Abnormal Electrocardiogram (ECG) Findings</title>
          <description>12-lead ECGs were measured in a semi-supine position using an automated ECG machine after approximately 5 minutes of rest for the participant. Abnormal findings were categorized as clinically significant (CS) and not clinically significant (NCS).</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Participants</units>
          <param>Count of Participants</param>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
                <count group_id="O9" value="16"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>CS, Day 1,1 hour n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1,2 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 4 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 6 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 12 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 1, 48 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 72 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 96 hour n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1,1 hour n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="1"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1,2 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1, 4 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1, 6 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 1, 12 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="1"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1, 24 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 1, 48 hours n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="1"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1, 72 hours, n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1, 96 hour n=6,6,6,6,6,6,6,6,15</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="15"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="0"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, FU (Day 15), n=6,6,6,6,6,6,6,6,16</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="6"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="6"/>
                    <count group_id="O6" value="6"/>
                    <count group_id="O7" value="6"/>
                    <count group_id="O8" value="6"/>
                    <count group_id="O9" value="16"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                    <measurement group_id="O6" value="0"/>
                    <measurement group_id="O7" value="2"/>
                    <measurement group_id="O8" value="0"/>
                    <measurement group_id="O9" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Number of Participants AEs and SAEs</title>
        <description>An AE is any untoward medical occurrence in a participant, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product. Any untoward event resulting in death, life threatening, requires hospitalization or prolongation of existing hospitalization, results in disability/incapacity, congenital anomaly/birth defect or any other situation according to medical or scientific judgment were categorized as SAE. Results are presented treatment wise.</description>
        <time_frame>Up to Day 28</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Number of Participants AEs and SAEs</title>
          <description>An AE is any untoward medical occurrence in a participant, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product. Any untoward event resulting in death, life threatening, requires hospitalization or prolongation of existing hospitalization, results in disability/incapacity, congenital anomaly/birth defect or any other situation according to medical or scientific judgment were categorized as SAE. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Participants</units>
          <param>Count of Participants</param>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>AE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4"/>
                    <measurement group_id="O2" value="5"/>
                    <measurement group_id="O3" value="19"/>
                    <measurement group_id="O4" value="6"/>
                    <measurement group_id="O5" value="10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SAE</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Abnormal Hematology Findings: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils, Platelets.</title>
        <description>Blood samples were collected at indicated time points to analyze the hematology parameters: basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), Pre dose on Days 2,4,6,8,10,12,14 Day 14 : 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Abnormal Hematology Findings: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils, Platelets.</title>
          <description>Blood samples were collected at indicated time points to analyze the hematology parameters: basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>10^9 cells/Liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Basophils, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.003" spread="0.0103"/>
                    <measurement group_id="O2" value="0.000" spread="0.0110"/>
                    <measurement group_id="O3" value="-0.004" spread="0.0111"/>
                    <measurement group_id="O4" value="0.001" spread="0.0069"/>
                    <measurement group_id="O5" value="-0.004" spread="0.0108"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.002" spread="0.0117"/>
                    <measurement group_id="O2" value="0.005" spread="0.0217"/>
                    <measurement group_id="O3" value="-0.001" spread="0.0108"/>
                    <measurement group_id="O4" value="0.001" spread="0.0107"/>
                    <measurement group_id="O5" value="-0.002" spread="0.0119"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.002" spread="0.0075"/>
                    <measurement group_id="O2" value="0.003" spread="0.0151"/>
                    <measurement group_id="O3" value="0.001" spread="0.0124"/>
                    <measurement group_id="O4" value="0.009" spread="0.0135"/>
                    <measurement group_id="O5" value="-0.002" spread="0.0105"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.005" spread="0.0138"/>
                    <measurement group_id="O2" value="0.012" spread="0.0214"/>
                    <measurement group_id="O3" value="0.004" spread="0.0147"/>
                    <measurement group_id="O4" value="0.014" spread="0.0098"/>
                    <measurement group_id="O5" value="-0.002" spread="0.0105"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.005" spread="0.0055"/>
                    <measurement group_id="O2" value="0.013" spread="0.0163"/>
                    <measurement group_id="O3" value="0.010" spread="0.0108"/>
                    <measurement group_id="O4" value="0.011" spread="0.0121"/>
                    <measurement group_id="O5" value="0.001" spread="0.0123"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.002" spread="0.0075"/>
                    <measurement group_id="O2" value="0.017" spread="0.0163"/>
                    <measurement group_id="O3" value="0.008" spread="0.0121"/>
                    <measurement group_id="O4" value="0.010" spread="0.0082"/>
                    <measurement group_id="O5" value="-0.001" spread="0.0100"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.003" spread="0.0052"/>
                    <measurement group_id="O2" value="0.002" spread="0.0214"/>
                    <measurement group_id="O3" value="0.007" spread="0.0140"/>
                    <measurement group_id="O4" value="0.017" spread="0.0082"/>
                    <measurement group_id="O5" value="-0.003" spread="0.0114"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.002" spread="0.0075"/>
                    <measurement group_id="O2" value="0.010" spread="0.0190"/>
                    <measurement group_id="O3" value="0.007" spread="0.0137"/>
                    <measurement group_id="O4" value="0.005" spread="0.0138"/>
                    <measurement group_id="O5" value="-0.001" spread="0.0103"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.002" spread="0.0075"/>
                    <measurement group_id="O2" value="0.010" spread="0.0228"/>
                    <measurement group_id="O3" value="0.004" spread="0.0110"/>
                    <measurement group_id="O4" value="0.007" spread="0.0121"/>
                    <measurement group_id="O5" value="-0.004" spread="0.0165"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Basophils, FU(Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.007" spread="0.0103"/>
                    <measurement group_id="O2" value="0.003" spread="0.0137"/>
                    <measurement group_id="O3" value="-0.003" spread="0.0124"/>
                    <measurement group_id="O4" value="-0.001" spread="0.0069"/>
                    <measurement group_id="O5" value="-0.006" spread="0.0150"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.015" spread="0.0176"/>
                    <measurement group_id="O2" value="0.032" spread="0.0147"/>
                    <measurement group_id="O3" value="0.006" spread="0.0728"/>
                    <measurement group_id="O4" value="0.050" spread="0.0663"/>
                    <measurement group_id="O5" value="-0.001" spread="0.0438"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.015" spread="0.0536"/>
                    <measurement group_id="O2" value="0.013" spread="0.0455"/>
                    <measurement group_id="O3" value="0.012" spread="0.0867"/>
                    <measurement group_id="O4" value="0.043" spread="0.0605"/>
                    <measurement group_id="O5" value="-0.006" spread="0.0520"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.043" spread="0.0665"/>
                    <measurement group_id="O2" value="0.007" spread="0.0528"/>
                    <measurement group_id="O3" value="0.000" spread="0.0876"/>
                    <measurement group_id="O4" value="0.034" spread="0.0832"/>
                    <measurement group_id="O5" value="0.000" spread="0.0411"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.027" spread="0.0516"/>
                    <measurement group_id="O2" value="0.030" spread="0.0529"/>
                    <measurement group_id="O3" value="-0.005" spread="0.0838"/>
                    <measurement group_id="O4" value="0.024" spread="0.0683"/>
                    <measurement group_id="O5" value="-0.007" spread="0.0395"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.028" spread="0.0426"/>
                    <measurement group_id="O2" value="0.053" spread="0.0539"/>
                    <measurement group_id="O3" value="0.025" spread="0.1057"/>
                    <measurement group_id="O4" value="0.026" spread="0.0824"/>
                    <measurement group_id="O5" value="-0.012" spread="0.0437"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.008" spread="0.0768"/>
                    <measurement group_id="O2" value="0.067" spread="0.0472"/>
                    <measurement group_id="O3" value="0.021" spread="0.1075"/>
                    <measurement group_id="O4" value="0.033" spread="0.0862"/>
                    <measurement group_id="O5" value="-0.012" spread="0.0519"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.017" spread="0.0602"/>
                    <measurement group_id="O2" value="0.013" spread="0.0468"/>
                    <measurement group_id="O3" value="0.019" spread="0.1192"/>
                    <measurement group_id="O4" value="0.048" spread="0.0794"/>
                    <measurement group_id="O5" value="0.011" spread="0.0589"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.003" spread="0.0468"/>
                    <measurement group_id="O2" value="0.047" spread="0.0513"/>
                    <measurement group_id="O3" value="0.000" spread="0.1193"/>
                    <measurement group_id="O4" value="0.048" spread="0.0893"/>
                    <measurement group_id="O5" value="0.009" spread="0.0770"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.045" spread="0.0647"/>
                    <measurement group_id="O2" value="0.043" spread="0.0437"/>
                    <measurement group_id="O3" value="0.004" spread="0.1167"/>
                    <measurement group_id="O4" value="0.050" spread="0.0851"/>
                    <measurement group_id="O5" value="0.001" spread="0.0584"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Eosinophils, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.055" spread="0.0373"/>
                    <measurement group_id="O2" value="0.017" spread="0.0659"/>
                    <measurement group_id="O3" value="-0.003" spread="0.1617"/>
                    <measurement group_id="O4" value="0.023" spread="0.0804"/>
                    <measurement group_id="O5" value="-0.041" spread="0.0618"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.203" spread="0.8721"/>
                    <measurement group_id="O2" value="0.275" spread="0.4329"/>
                    <measurement group_id="O3" value="0.355" spread="1.6576"/>
                    <measurement group_id="O4" value="-0.081" spread="0.4831"/>
                    <measurement group_id="O5" value="-0.202" spread="1.2439"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.170" spread="0.8864"/>
                    <measurement group_id="O2" value="0.123" spread="0.5792"/>
                    <measurement group_id="O3" value="-0.096" spread="0.9361"/>
                    <measurement group_id="O4" value="0.063" spread="0.9600"/>
                    <measurement group_id="O5" value="-0.250" spread="1.3609"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.158" spread="1.1274"/>
                    <measurement group_id="O2" value="0.052" spread="0.4839"/>
                    <measurement group_id="O3" value="0.100" spread="1.3054"/>
                    <measurement group_id="O4" value="-0.347" spread="0.6065"/>
                    <measurement group_id="O5" value="-0.026" spread="1.3748"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.043" spread="0.8500"/>
                    <measurement group_id="O2" value="0.178" spread="0.6011"/>
                    <measurement group_id="O3" value="-0.011" spread="0.9496"/>
                    <measurement group_id="O4" value="-0.481" spread="1.2000"/>
                    <measurement group_id="O5" value="-0.144" spread="1.3225"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.117" spread="0.8565"/>
                    <measurement group_id="O2" value="0.515" spread="0.4821"/>
                    <measurement group_id="O3" value="0.296" spread="0.8216"/>
                    <measurement group_id="O4" value="-0.584" spread="1.1299"/>
                    <measurement group_id="O5" value="0.064" spread="1.5507"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.538" spread="1.0626"/>
                    <measurement group_id="O2" value="0.810" spread="0.4692"/>
                    <measurement group_id="O3" value="0.165" spread="0.8511"/>
                    <measurement group_id="O4" value="-0.567" spread="1.2112"/>
                    <measurement group_id="O5" value="-0.052" spread="1.4813"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.200" spread="0.8402"/>
                    <measurement group_id="O2" value="-0.053" spread="0.4230"/>
                    <measurement group_id="O3" value="0.180" spread="1.0249"/>
                    <measurement group_id="O4" value="-0.433" spread="0.9609"/>
                    <measurement group_id="O5" value="0.046" spread="1.3461"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.028" spread="0.7348"/>
                    <measurement group_id="O2" value="0.187" spread="0.4774"/>
                    <measurement group_id="O3" value="0.097" spread="1.0672"/>
                    <measurement group_id="O4" value="-0.597" spread="1.2776"/>
                    <measurement group_id="O5" value="0.104" spread="1.2821"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.438" spread="1.0624"/>
                    <measurement group_id="O2" value="0.300" spread="0.4367"/>
                    <measurement group_id="O3" value="0.336" spread="1.1083"/>
                    <measurement group_id="O4" value="-0.248" spread="1.6414"/>
                    <measurement group_id="O5" value="0.347" spread="1.3089"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Leukocytes, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.148" spread="0.7008"/>
                    <measurement group_id="O2" value="0.263" spread="1.6261"/>
                    <measurement group_id="O3" value="-0.209" spread="0.8990"/>
                    <measurement group_id="O4" value="-0.709" spread="1.2790"/>
                    <measurement group_id="O5" value="-0.049" spread="1.1939"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.003" spread="0.4892"/>
                    <measurement group_id="O2" value="0.092" spread="0.4111"/>
                    <measurement group_id="O3" value="0.013" spread="0.3249"/>
                    <measurement group_id="O4" value="0.163" spread="0.3174"/>
                    <measurement group_id="O5" value="-0.026" spread="0.4478"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.008" spread="0.6814"/>
                    <measurement group_id="O2" value="-0.067" spread="0.5230"/>
                    <measurement group_id="O3" value="0.000" spread="0.3242"/>
                    <measurement group_id="O4" value="0.194" spread="0.4500"/>
                    <measurement group_id="O5" value="-0.003" spread="0.4739"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.035" spread="0.7416"/>
                    <measurement group_id="O2" value="-0.017" spread="0.5384"/>
                    <measurement group_id="O3" value="0.147" spread="0.3174"/>
                    <measurement group_id="O4" value="0.210" spread="0.5157"/>
                    <measurement group_id="O5" value="0.112" spread="0.3739"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.035" spread="0.6427"/>
                    <measurement group_id="O2" value="0.100" spread="0.5655"/>
                    <measurement group_id="O3" value="0.140" spread="0.2862"/>
                    <measurement group_id="O4" value="0.229" spread="0.4557"/>
                    <measurement group_id="O5" value="0.013" spread="0.4660"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.053" spread="0.7320"/>
                    <measurement group_id="O2" value="0.185" spread="0.5404"/>
                    <measurement group_id="O3" value="0.232" spread="0.3580"/>
                    <measurement group_id="O4" value="0.190" spread="0.5199"/>
                    <measurement group_id="O5" value="0.085" spread="0.4055"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.177" spread="0.7096"/>
                    <measurement group_id="O2" value="0.332" spread="0.3874"/>
                    <measurement group_id="O3" value="0.180" spread="0.4106"/>
                    <measurement group_id="O4" value="0.231" spread="0.5225"/>
                    <measurement group_id="O5" value="0.054" spread="0.5013"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.078" spread="0.5286"/>
                    <measurement group_id="O2" value="-0.055" spread="0.4773"/>
                    <measurement group_id="O3" value="0.186" spread="0.2944"/>
                    <measurement group_id="O4" value="0.125" spread="0.4923"/>
                    <measurement group_id="O5" value="0.061" spread="0.4643"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.022" spread="0.5561"/>
                    <measurement group_id="O2" value="0.135" spread="0.3746"/>
                    <measurement group_id="O3" value="0.180" spread="0.3403"/>
                    <measurement group_id="O4" value="0.072" spread="0.4776"/>
                    <measurement group_id="O5" value="0.044" spread="0.4554"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.060" spread="0.5114"/>
                    <measurement group_id="O2" value="0.255" spread="0.4602"/>
                    <measurement group_id="O3" value="0.247" spread="0.3308"/>
                    <measurement group_id="O4" value="0.193" spread="0.7185"/>
                    <measurement group_id="O5" value="0.059" spread="0.4478"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Lymphocytes, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.512" spread="0.5189"/>
                    <measurement group_id="O2" value="-0.280" spread="0.5637"/>
                    <measurement group_id="O3" value="-0.144" spread="0.4368"/>
                    <measurement group_id="O4" value="-0.237" spread="0.3583"/>
                    <measurement group_id="O5" value="-0.184" spread="0.2858"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.003" spread="0.1046"/>
                    <measurement group_id="O2" value="-0.038" spread="0.0791"/>
                    <measurement group_id="O3" value="0.011" spread="0.1690"/>
                    <measurement group_id="O4" value="-0.026" spread="0.0948"/>
                    <measurement group_id="O5" value="-0.042" spread="0.0982"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.023" spread="0.0804"/>
                    <measurement group_id="O2" value="-0.037" spread="0.0905"/>
                    <measurement group_id="O3" value="-0.001" spread="0.1085"/>
                    <measurement group_id="O4" value="-0.023" spread="0.1052"/>
                    <measurement group_id="O5" value="-0.029" spread="0.1018"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.030" spread="0.1489"/>
                    <measurement group_id="O2" value="-0.075" spread="0.0817"/>
                    <measurement group_id="O3" value="-0.019" spread="0.1169"/>
                    <measurement group_id="O4" value="-0.067" spread="0.0808"/>
                    <measurement group_id="O5" value="-0.021" spread="0.1045"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.012" spread="0.1068"/>
                    <measurement group_id="O2" value="-0.057" spread="0.1063"/>
                    <measurement group_id="O3" value="-0.018" spread="0.1006"/>
                    <measurement group_id="O4" value="-0.001" spread="0.1192"/>
                    <measurement group_id="O5" value="-0.005" spread="0.1005"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.003" spread="0.1204"/>
                    <measurement group_id="O2" value="0.020" spread="0.1115"/>
                    <measurement group_id="O3" value="0.016" spread="0.0881"/>
                    <measurement group_id="O4" value="-0.021" spread="0.1122"/>
                    <measurement group_id="O5" value="-0.001" spread="0.1356"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.023" spread="0.0942"/>
                    <measurement group_id="O2" value="0.022" spread="0.1269"/>
                    <measurement group_id="O3" value="-0.002" spread="0.0926"/>
                    <measurement group_id="O4" value="-0.011" spread="0.1530"/>
                    <measurement group_id="O5" value="-0.009" spread="0.1244"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.037" spread="0.1084"/>
                    <measurement group_id="O2" value="-0.008" spread="0.0773"/>
                    <measurement group_id="O3" value="-0.023" spread="0.1044"/>
                    <measurement group_id="O4" value="-0.027" spread="0.1226"/>
                    <measurement group_id="O5" value="0.003" spread="0.1007"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.005" spread="0.1093"/>
                    <measurement group_id="O2" value="-0.040" spread="0.0947"/>
                    <measurement group_id="O3" value="-0.019" spread="0.1158"/>
                    <measurement group_id="O4" value="-0.050" spread="0.1352"/>
                    <measurement group_id="O5" value="0.004" spread="0.0756"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.035" spread="0.0961"/>
                    <measurement group_id="O2" value="-0.030" spread="0.1077"/>
                    <measurement group_id="O3" value="0.006" spread="0.1323"/>
                    <measurement group_id="O4" value="-0.002" spread="0.1450"/>
                    <measurement group_id="O5" value="0.038" spread="0.1207"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Monocytes, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.083" spread="0.1037"/>
                    <measurement group_id="O2" value="-0.030" spread="0.1188"/>
                    <measurement group_id="O3" value="-0.036" spread="0.0937"/>
                    <measurement group_id="O4" value="0.013" spread="0.1883"/>
                    <measurement group_id="O5" value="-0.051" spread="0.0778"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.178" spread="0.5500"/>
                    <measurement group_id="O2" value="0.190" spread="0.5981"/>
                    <measurement group_id="O3" value="0.328" spread="1.5779"/>
                    <measurement group_id="O4" value="-0.273" spread="0.6049"/>
                    <measurement group_id="O5" value="-0.128" spread="1.0189"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.188" spread="0.3853"/>
                    <measurement group_id="O2" value="0.207" spread="0.3747"/>
                    <measurement group_id="O3" value="-0.107" spread="0.8863"/>
                    <measurement group_id="O4" value="-0.153" spread="1.0017"/>
                    <measurement group_id="O5" value="-0.209" spread="1.0416"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.177" spread="0.4173"/>
                    <measurement group_id="O2" value="0.135" spread="0.3031"/>
                    <measurement group_id="O3" value="-0.030" spread="1.1214"/>
                    <measurement group_id="O4" value="-0.533" spread="0.6285"/>
                    <measurement group_id="O5" value="-0.114" spread="1.1418"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.038" spread="0.2525"/>
                    <measurement group_id="O2" value="0.097" spread="0.3894"/>
                    <measurement group_id="O3" value="-0.132" spread="0.8619"/>
                    <measurement group_id="O4" value="-0.746" spread="1.2632"/>
                    <measurement group_id="O5" value="-0.141" spread="1.0976"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.028" spread="0.1317"/>
                    <measurement group_id="O2" value="0.240" spread="0.3099"/>
                    <measurement group_id="O3" value="0.012" spread="0.8357"/>
                    <measurement group_id="O4" value="-0.791" spread="1.1634"/>
                    <measurement group_id="O5" value="-0.008" spread="1.3122"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.328" spread="0.3414"/>
                    <measurement group_id="O2" value="0.373" spread="0.3690"/>
                    <measurement group_id="O3" value="-0.042" spread="0.7593"/>
                    <measurement group_id="O4" value="-0.831" spread="1.1224"/>
                    <measurement group_id="O5" value="-0.083" spread="1.1305"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.222" spread="0.4540"/>
                    <measurement group_id="O2" value="-0.007" spread="0.4620"/>
                    <measurement group_id="O3" value="-0.011" spread="0.9244"/>
                    <measurement group_id="O4" value="-0.598" spread="0.9450"/>
                    <measurement group_id="O5" value="-0.026" spread="1.1249"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.048" spread="0.3746"/>
                    <measurement group_id="O2" value="0.035" spread="0.7028"/>
                    <measurement group_id="O3" value="-0.072" spread="0.9007"/>
                    <measurement group_id="O4" value="-0.673" spread="1.2453"/>
                    <measurement group_id="O5" value="0.049" spread="1.1598"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.292" spread="0.5710"/>
                    <measurement group_id="O2" value="0.017" spread="0.5775"/>
                    <measurement group_id="O3" value="0.075" spread="0.9796"/>
                    <measurement group_id="O4" value="-0.497" spread="1.0625"/>
                    <measurement group_id="O5" value="0.255" spread="1.1764"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Neutrophils, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.490" spread="0.3072"/>
                    <measurement group_id="O2" value="0.555" spread="1.9413"/>
                    <measurement group_id="O3" value="-0.024" spread="0.7404"/>
                    <measurement group_id="O4" value="-0.509" spread="1.3465"/>
                    <measurement group_id="O5" value="0.235" spread="1.3115"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, Day 2, predose, n=6,5,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.7" spread="18.78"/>
                    <measurement group_id="O2" value="9.8" spread="6.94"/>
                    <measurement group_id="O3" value="5.4" spread="13.46"/>
                    <measurement group_id="O4" value="17.9" spread="18.89"/>
                    <measurement group_id="O5" value="1.3" spread="20.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, Day 4, predose, n=6,5,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.5" spread="12.76"/>
                    <measurement group_id="O2" value="-11.2" spread="8.23"/>
                    <measurement group_id="O3" value="2.5" spread="16.28"/>
                    <measurement group_id="O4" value="17.6" spread="31.86"/>
                    <measurement group_id="O5" value="-3.6" spread="21.81"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.2" spread="20.61"/>
                    <measurement group_id="O2" value="10.3" spread="14.73"/>
                    <measurement group_id="O3" value="3.4" spread="18.67"/>
                    <measurement group_id="O4" value="17.1" spread="13.28"/>
                    <measurement group_id="O5" value="3.3" spread="25.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, Day 8 predose, n=6,5,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.8" spread="8.82"/>
                    <measurement group_id="O2" value="4.4" spread="13.87"/>
                    <measurement group_id="O3" value="8.6" spread="19.14"/>
                    <measurement group_id="O4" value="16.7" spread="21.66"/>
                    <measurement group_id="O5" value="0.4" spread="31.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.7" spread="16.38"/>
                    <measurement group_id="O2" value="14.7" spread="11.34"/>
                    <measurement group_id="O3" value="8.0" spread="30.98"/>
                    <measurement group_id="O4" value="14.3" spread="12.38"/>
                    <measurement group_id="O5" value="4.8" spread="31.48"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.5" spread="27.40"/>
                    <measurement group_id="O2" value="9.8" spread="19.02"/>
                    <measurement group_id="O3" value="3.6" spread="34.68"/>
                    <measurement group_id="O4" value="6.1" spread="15.00"/>
                    <measurement group_id="O5" value="2.9" spread="28.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.3" spread="23.52"/>
                    <measurement group_id="O2" value="-6.2" spread="19.30"/>
                    <measurement group_id="O3" value="8.3" spread="25.49"/>
                    <measurement group_id="O4" value="7.8" spread="19.74"/>
                    <measurement group_id="O5" value="-2.9" spread="31.90"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.0" spread="13.73"/>
                    <measurement group_id="O2" value="-2.8" spread="13.70"/>
                    <measurement group_id="O3" value="1.3" spread="21.79"/>
                    <measurement group_id="O4" value="-2.2" spread="17.99"/>
                    <measurement group_id="O5" value="-1.1" spread="34.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-4.3" spread="9.93"/>
                    <measurement group_id="O2" value="-3.3" spread="20.74"/>
                    <measurement group_id="O3" value="1.0" spread="23.54"/>
                    <measurement group_id="O4" value="-17.3" spread="33.99"/>
                    <measurement group_id="O5" value="-5.4" spread="25.19"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Platelets, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-8.7" spread="10.75"/>
                    <measurement group_id="O2" value="-11.8" spread="20.02"/>
                    <measurement group_id="O3" value="-3.9" spread="21.61"/>
                    <measurement group_id="O4" value="-4.0" spread="28.3"/>
                    <measurement group_id="O5" value="-5.3" spread="39.09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Hematology Parameter: Erythrocytes</title>
        <description>Blood samples were collected at indicated time points to analyze the hematology parameters: Erythrocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
        <time_frame>Baseline (Day -2), Pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Hematology Parameter: Erythrocytes</title>
          <description>Blood samples were collected at indicated time points to analyze the hematology parameters: Erythrocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>10^12 cells/Liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.135" spread="0.2601"/>
                    <measurement group_id="O2" value="0.200" spread="0.1411"/>
                    <measurement group_id="O3" value="0.128" spread="0.2539"/>
                    <measurement group_id="O4" value="0.440" spread="0.1458"/>
                    <measurement group_id="O5" value="0.131" spread="0.2100"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.193" spread="0.2322"/>
                    <measurement group_id="O2" value="0.112" spread="0.1057"/>
                    <measurement group_id="O3" value="0.086" spread="0.2099"/>
                    <measurement group_id="O4" value="0.544" spread="0.1318"/>
                    <measurement group_id="O5" value="0.091" spread="0.1589"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.197" spread="0.3267"/>
                    <measurement group_id="O2" value="0.230" spread="0.0994"/>
                    <measurement group_id="O3" value="0.088" spread="0.2160"/>
                    <measurement group_id="O4" value="0.323" spread="0.1614"/>
                    <measurement group_id="O5" value="0.146" spread="0.1480"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.035" spread="0.3056"/>
                    <measurement group_id="O2" value="0.272" spread="0.1685"/>
                    <measurement group_id="O3" value="0.088" spread="0.2352"/>
                    <measurement group_id="O4" value="0.327" spread="0.1940"/>
                    <measurement group_id="O5" value="0.115" spread="0.1816"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.082" spread="0.3415"/>
                    <measurement group_id="O2" value="0.293" spread="0.2238"/>
                    <measurement group_id="O3" value="0.179" spread="0.1861"/>
                    <measurement group_id="O4" value="0.306" spread="0.1334"/>
                    <measurement group_id="O5" value="0.206" spread="0.1637"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.078" spread="0.2423"/>
                    <measurement group_id="O2" value="0.387" spread="0.1643"/>
                    <measurement group_id="O3" value="0.139" spread="0.2004"/>
                    <measurement group_id="O4" value="0.296" spread="0.1049"/>
                    <measurement group_id="O5" value="0.179" spread="0.1372"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.017" spread="0.2243"/>
                    <measurement group_id="O2" value="0.037" spread="0.1394"/>
                    <measurement group_id="O3" value="0.031" spread="0.2429"/>
                    <measurement group_id="O4" value="0.385" spread="0.2288"/>
                    <measurement group_id="O5" value="0.005" spread="0.1931"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.002" spread="0.2416"/>
                    <measurement group_id="O2" value="0.177" spread="0.2253"/>
                    <measurement group_id="O3" value="0.109" spread="0.2116"/>
                    <measurement group_id="O4" value="0.323" spread="0.2219"/>
                    <measurement group_id="O5" value="0.182" spread="0.2198"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.042" spread="0.1597"/>
                    <measurement group_id="O2" value="0.215" spread="0.2095"/>
                    <measurement group_id="O3" value="0.068" spread="0.2039"/>
                    <measurement group_id="O4" value="0.327" spread="0.1159"/>
                    <measurement group_id="O5" value="0.156" spread="0.1938"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 28),n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.187" spread="0.1632"/>
                    <measurement group_id="O2" value="-0.123" spread="0.1835"/>
                    <measurement group_id="O3" value="-0.093" spread="0.2015"/>
                    <measurement group_id="O4" value="0.050" spread="0.2484"/>
                    <measurement group_id="O5" value="-0.081" spread="0.2517"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Hematology Parameter: Erythrocytes MCV</title>
        <description>Blood samples were collected at indicated time points to analyze the hematology parameters: Erythrocyte MCV. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
        <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Hematology Parameter: Erythrocytes MCV</title>
          <description>Blood samples were collected at indicated time points to analyze the hematology parameters: Erythrocyte MCV. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Femtoliter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.20" spread="0.559"/>
                    <measurement group_id="O2" value="-0.63" spread="0.989"/>
                    <measurement group_id="O3" value="-0.27" spread="1.223"/>
                    <measurement group_id="O4" value="-1.13" spread="1.280"/>
                    <measurement group_id="O5" value="-0.16" spread="1.126"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.50" spread="0.777"/>
                    <measurement group_id="O2" value="-1.05" spread="1.009"/>
                    <measurement group_id="O3" value="-0.18" spread="1.321"/>
                    <measurement group_id="O4" value="-0.19" spread="1.227"/>
                    <measurement group_id="O5" value="0.17" spread="0.675"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.25" spread="0.683"/>
                    <measurement group_id="O2" value="0.10" spread="1.368"/>
                    <measurement group_id="O3" value="-0.02" spread="1.422"/>
                    <measurement group_id="O4" value="-1.30" spread="1.390"/>
                    <measurement group_id="O5" value="0.62" spread="1.188"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.03" spread="0.308"/>
                    <measurement group_id="O2" value="-0.60" spread="1.226"/>
                    <measurement group_id="O3" value="-0.53" spread="1.390"/>
                    <measurement group_id="O4" value="-0.67" spread="1.566"/>
                    <measurement group_id="O5" value="0.79" spread="1.299"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.02" spread="0.534"/>
                    <measurement group_id="O2" value="-0.73" spread="1.025"/>
                    <measurement group_id="O3" value="-0.70" spread="1.635"/>
                    <measurement group_id="O4" value="-0.90" spread="0.933"/>
                    <measurement group_id="O5" value="0.21" spread="1.278"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.33" spread="0.838"/>
                    <measurement group_id="O2" value="-0.55" spread="1.017"/>
                    <measurement group_id="O3" value="-0.34" spread="0.908"/>
                    <measurement group_id="O4" value="-0.99" spread="0.747"/>
                    <measurement group_id="O5" value="0.16" spread="1.161"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.73" spread="0.864"/>
                    <measurement group_id="O2" value="0.72" spread="0.995"/>
                    <measurement group_id="O3" value="-0.86" spread="1.693"/>
                    <measurement group_id="O4" value="-1.92" spread="1.059"/>
                    <measurement group_id="O5" value="0.26" spread="1.585"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.52" spread="0.560"/>
                    <measurement group_id="O2" value="-0.40" spread="1.322"/>
                    <measurement group_id="O3" value="-0.67" spread="1.209"/>
                    <measurement group_id="O4" value="-1.30" spread="0.629"/>
                    <measurement group_id="O5" value="0.01" spread="1.210"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.55" spread="0.409"/>
                    <measurement group_id="O2" value="-0.25" spread="1.122"/>
                    <measurement group_id="O3" value="-0.53" spread="1.361"/>
                    <measurement group_id="O4" value="-0.50" spread="0.738"/>
                    <measurement group_id="O5" value="0.14" spread="1.329"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00" spread="0.678"/>
                    <measurement group_id="O2" value="0.63" spread="0.459"/>
                    <measurement group_id="O3" value="-0.65" spread="1.447"/>
                    <measurement group_id="O4" value="-1.19" spread="0.832"/>
                    <measurement group_id="O5" value="0.61" spread="1.215"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Hematology Parameter: Erythrocytes Mean Corpuscular Hemoglobin (Erythrocyte MCH)</title>
        <description>Blood samples were collected at indicated time points to analyze the hematology parameter: Erythrocyte MCH. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
        <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Hematology Parameter: Erythrocytes Mean Corpuscular Hemoglobin (Erythrocyte MCH)</title>
          <description>Blood samples were collected at indicated time points to analyze the hematology parameter: Erythrocyte MCH. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>Picograms</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.10" spread="0.443"/>
                    <measurement group_id="O2" value="-0.35" spread="0.217"/>
                    <measurement group_id="O3" value="-0.08" spread="0.578"/>
                    <measurement group_id="O4" value="-0.46" spread="0.670"/>
                    <measurement group_id="O5" value="-0.14" spread="0.759"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.32" spread="0.306"/>
                    <measurement group_id="O2" value="-0.03" spread="0.367"/>
                    <measurement group_id="O3" value="0.06" spread="0.607"/>
                    <measurement group_id="O4" value="-0.40" spread="0.408"/>
                    <measurement group_id="O5" value="0.09" spread="0.684"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.43" spread="0.413"/>
                    <measurement group_id="O2" value="-0.78" spread="0.172"/>
                    <measurement group_id="O3" value="0.06" spread="0.788"/>
                    <measurement group_id="O4" value="-0.30" spread="0.606"/>
                    <measurement group_id="O5" value="-0.06" spread="0.677"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.23" spread="0.602"/>
                    <measurement group_id="O2" value="-0.55" spread="0.226"/>
                    <measurement group_id="O3" value="0.08" spread="0.785"/>
                    <measurement group_id="O4" value="-0.43" spread="0.577"/>
                    <measurement group_id="O5" value="0.21" spread="0.673"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.22" spread="0.571"/>
                    <measurement group_id="O2" value="-0.67" spread="0.339"/>
                    <measurement group_id="O3" value="-0.08" spread="0.573"/>
                    <measurement group_id="O4" value="-0.26" spread="0.544"/>
                    <measurement group_id="O5" value="0.01" spread="0.617"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00" spread="0.522"/>
                    <measurement group_id="O2" value="-0.68" spread="0.248"/>
                    <measurement group_id="O3" value="0.00" spread="0.450"/>
                    <measurement group_id="O4" value="-0.10" spread="0.742"/>
                    <measurement group_id="O5" value="-0.06" spread="0.557"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00" spread="0.310"/>
                    <measurement group_id="O2" value="-0.72" spread="0.264"/>
                    <measurement group_id="O3" value="-0.02" spread="0.724"/>
                    <measurement group_id="O4" value="-0.57" spread="0.728"/>
                    <measurement group_id="O5" value="-0.04" spread="0.637"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.08" spread="0.504"/>
                    <measurement group_id="O2" value="-0.68" spread="0.293"/>
                    <measurement group_id="O3" value="-0.12" spread="0.598"/>
                    <measurement group_id="O4" value="-0.17" spread="0.698"/>
                    <measurement group_id="O5" value="-0.15" spread="0.557"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.25" spread="0.647"/>
                    <measurement group_id="O2" value="-0.87" spread="0.216"/>
                    <measurement group_id="O3" value="-0.20" spread="0.520"/>
                    <measurement group_id="O4" value="-0.65" spread="0.740"/>
                    <measurement group_id="O5" value="0.00" spread="0.477"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU, (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.03" spread="0.427"/>
                    <measurement group_id="O2" value="-0.60" spread="0.237"/>
                    <measurement group_id="O3" value="-0.04" spread="0.644"/>
                    <measurement group_id="O4" value="-0.36" spread="0.412"/>
                    <measurement group_id="O5" value="0.01" spread="0.637"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Hematology Parameter: Hematocrit</title>
        <description>Blood samples were collected at indicated time points to analyze the hematology parameter: hematocrit. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Hematology Parameter: Hematocrit</title>
          <description>Blood samples were collected at indicated time points to analyze the hematology parameter: hematocrit. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Percentage of red blood cells in blood</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0102" spread="0.02300"/>
                    <measurement group_id="O2" value="0.0140" spread="0.01425"/>
                    <measurement group_id="O3" value="0.0096" spread="0.01995"/>
                    <measurement group_id="O4" value="0.0314" spread="0.01122"/>
                    <measurement group_id="O5" value="0.0108" spread="0.01712"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0133" spread="0.02270"/>
                    <measurement group_id="O2" value="0.0043" spread="0.01154"/>
                    <measurement group_id="O3" value="0.0066" spread="0.01855"/>
                    <measurement group_id="O4" value="0.0453" spread="0.01067"/>
                    <measurement group_id="O5" value="0.0085" spread="0.01459"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0148" spread="0.03205"/>
                    <measurement group_id="O2" value="0.0202" spread="0.01304"/>
                    <measurement group_id="O3" value="0.0075" spread="0.01857"/>
                    <measurement group_id="O4" value="0.0206" spread="0.01397"/>
                    <measurement group_id="O5" value="0.0155" spread="0.01108"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0025" spread="0.02788"/>
                    <measurement group_id="O2" value="0.0203" spread="0.01250"/>
                    <measurement group_id="O3" value="0.0049" spread="0.01827"/>
                    <measurement group_id="O4" value="0.0241" spread="0.01378"/>
                    <measurement group_id="O5" value="0.0137" spread="0.01431"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0063" spread="0.03144"/>
                    <measurement group_id="O2" value="0.0217" spread="0.01697"/>
                    <measurement group_id="O3" value="0.0119" spread="0.02108"/>
                    <measurement group_id="O4" value="0.0216" spread="0.00872"/>
                    <measurement group_id="O5" value="0.0191" spread="0.01466"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0047" spread="0.02439"/>
                    <measurement group_id="O2" value="0.0302" spread="0.01396"/>
                    <measurement group_id="O3" value="0.0102" spread="0.01872"/>
                    <measurement group_id="O4" value="0.0203" spread="0.00739"/>
                    <measurement group_id="O5" value="0.0159" spread="0.01201"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.0027" spread="0.02276"/>
                    <measurement group_id="O2" value="0.0070" spread="0.01053"/>
                    <measurement group_id="O3" value="-0.0014" spread="0.02132"/>
                    <measurement group_id="O4" value="0.0227" spread="0.01825"/>
                    <measurement group_id="O5" value="0.0019" spread="0.01499"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0003" spread="0.01419"/>
                    <measurement group_id="O2" value="0.0170" spread="0.01665"/>
                    <measurement group_id="O3" value="0.0032" spread="0.01808"/>
                    <measurement group_id="O4" value="0.0255" spread="0.01086"/>
                    <measurement group_id="O5" value="0.0145" spread="0.01594"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0018" spread="0.01969"/>
                    <measurement group_id="O2" value="0.0133" spread="0.01375"/>
                    <measurement group_id="O3" value="0.0060" spread="0.01664"/>
                    <measurement group_id="O4" value="0.0212" spread="0.01734"/>
                    <measurement group_id="O5" value="0.0157" spread="0.01601"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.0158" spread="0.01587"/>
                    <measurement group_id="O2" value="-0.0070" spread="0.01628"/>
                    <measurement group_id="O3" value="-0.0110" spread="0.01675"/>
                    <measurement group_id="O4" value="-0.0013" spread="0.01739"/>
                    <measurement group_id="O5" value="-0.0046" spread="0.02040"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Hematology Parameter: Percentage of Reticulocytes</title>
        <description>Blood samples were collected to analyze the hematology parameter: percentage of reticulocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Hematology Parameter: Percentage of Reticulocytes</title>
          <description>Blood samples were collected to analyze the hematology parameter: percentage of reticulocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>10^12 cells per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00093" spread="0.001204"/>
                    <measurement group_id="O2" value="-0.00103" spread="0.001214"/>
                    <measurement group_id="O3" value="0.00088" spread="0.001818"/>
                    <measurement group_id="O4" value="-0.00037" spread="0.001190"/>
                    <measurement group_id="O5" value="0.00117" spread="0.001333"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00215" spread="0.001099"/>
                    <measurement group_id="O2" value="-0.00032" spread="0.001440"/>
                    <measurement group_id="O3" value="0.00131" spread="0.002263"/>
                    <measurement group_id="O4" value="0.00124" spread="0.001996"/>
                    <measurement group_id="O5" value="0.00157" spread="0.001778"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00232" spread="0.000999"/>
                    <measurement group_id="O2" value="0.00138" spread="0.001118"/>
                    <measurement group_id="O3" value="0.00125" spread="0.002761"/>
                    <measurement group_id="O4" value="0.00106" spread="0.002192"/>
                    <measurement group_id="O5" value="0.00208" spread="0.001785"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00173" spread="0.001143"/>
                    <measurement group_id="O2" value="0.00213" spread="0.000894"/>
                    <measurement group_id="O3" value="0.00154" spread="0.002999"/>
                    <measurement group_id="O4" value="0.00031" spread="0.001780"/>
                    <measurement group_id="O5" value="0.00243" spread="0.002265"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00203" spread="0.000804"/>
                    <measurement group_id="O2" value="0.00255" spread="0.001450"/>
                    <measurement group_id="O3" value="0.00153" spread="0.002881"/>
                    <measurement group_id="O4" value="-0.00023" spread="0.001186"/>
                    <measurement group_id="O5" value="0.00154" spread="0.002233"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00220" spread="0.001075"/>
                    <measurement group_id="O2" value="0.00313" spread="0.001468"/>
                    <measurement group_id="O3" value="0.00205" spread="0.002889"/>
                    <measurement group_id="O4" value="0.00007" spread="0.001643"/>
                    <measurement group_id="O5" value="0.00161" spread="0.002094"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00287" spread="0.001810"/>
                    <measurement group_id="O2" value="0.00318" spread="0.000842"/>
                    <measurement group_id="O3" value="0.00212" spread="0.002924"/>
                    <measurement group_id="O4" value="-0.00015" spread="0.001621"/>
                    <measurement group_id="O5" value="0.00171" spread="0.002176"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00270" spread="0.001788"/>
                    <measurement group_id="O2" value="0.00295" spread="0.001524"/>
                    <measurement group_id="O3" value="0.00205" spread="0.003168"/>
                    <measurement group_id="O4" value="0.00063" spread="0.001429"/>
                    <measurement group_id="O5" value="0.00184" spread="0.003189"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00222" spread="0.001766"/>
                    <measurement group_id="O2" value="0.00163" spread="0.001780"/>
                    <measurement group_id="O3" value="0.00195" spread="0.003251"/>
                    <measurement group_id="O4" value="0.00013" spread="0.001680"/>
                    <measurement group_id="O5" value="0.00111" spread="0.002838"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU, (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.00177" spread="0.001581"/>
                    <measurement group_id="O2" value="0.00212" spread="0.002369"/>
                    <measurement group_id="O3" value="0.00095" spread="0.003073"/>
                    <measurement group_id="O4" value="-0.00084" spread="0.003085"/>
                    <measurement group_id="O5" value="0.00104" spread="0.002853"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Hematology Parameter: Hb</title>
        <description>Blood samples were collected at indicated time points to analyze the hematology parameter: Hb. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
        <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Hematology Parameter: Hb</title>
          <description>Blood samples were collected at indicated time points to analyze the hematology parameter: Hb. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>Grams per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="6.28"/>
                    <measurement group_id="O2" value="4.3" spread="4.13"/>
                    <measurement group_id="O3" value="3.4" spread="7.18"/>
                    <measurement group_id="O4" value="10.6" spread="3.31"/>
                    <measurement group_id="O5" value="3.4" spread="5.73"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.8" spread="5.49"/>
                    <measurement group_id="O2" value="3.2" spread="2.48"/>
                    <measurement group_id="O3" value="2.8" spread="6.28"/>
                    <measurement group_id="O4" value="13.9" spread="3.02"/>
                    <measurement group_id="O5" value="3.1" spread="4.71"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.5" spread="8.57"/>
                    <measurement group_id="O2" value="2.8" spread="3.19"/>
                    <measurement group_id="O3" value="3.0" spread="5.91"/>
                    <measurement group_id="O4" value="7.7" spread="3.77"/>
                    <measurement group_id="O5" value="3.9" spread="3.87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="6.95"/>
                    <measurement group_id="O2" value="5.3" spread="5.89"/>
                    <measurement group_id="O3" value="3.1" spread="5.93"/>
                    <measurement group_id="O4" value="7.3" spread="4.31"/>
                    <measurement group_id="O5" value="4.2" spread="5.91"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.2" spread="8.45"/>
                    <measurement group_id="O2" value="5.5" spread="6.22"/>
                    <measurement group_id="O3" value="4.9" spread="6.56"/>
                    <measurement group_id="O4" value="7.7" spread="3.50"/>
                    <measurement group_id="O5" value="6.3" spread="5.80"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.3" spread="6.62"/>
                    <measurement group_id="O2" value="8.0" spread="5.83"/>
                    <measurement group_id="O3" value="4.1" spread="5.70"/>
                    <measurement group_id="O4" value="8.1" spread="3.08"/>
                    <measurement group_id="O5" value="4.9" spread="4.10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.3" spread="5.20"/>
                    <measurement group_id="O2" value="-2.5" spread="4.23"/>
                    <measurement group_id="O3" value="0.9" spread="7.16"/>
                    <measurement group_id="O4" value="8.3" spread="3.33"/>
                    <measurement group_id="O5" value="0.2" spread="6.15"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.2" spread="4.92"/>
                    <measurement group_id="O2" value="1.8" spread="7.39"/>
                    <measurement group_id="O3" value="2.8" spread="6.37"/>
                    <measurement group_id="O4" value="8.8" spread="4.58"/>
                    <measurement group_id="O5" value="4.5" spread="6.42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.2" spread="3.13"/>
                    <measurement group_id="O2" value="2.2" spread="5.98"/>
                    <measurement group_id="O3" value="1.1" spread="6.52"/>
                    <measurement group_id="O4" value="6.5" spread="2.88"/>
                    <measurement group_id="O5" value="4.7" spread="5.09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-5.3" spread="4.18"/>
                    <measurement group_id="O2" value="-6.5" spread="5.82"/>
                    <measurement group_id="O3" value="-2.9" spread="5.51"/>
                    <measurement group_id="O4" value="-0.3" spread="7.54"/>
                    <measurement group_id="O5" value="-2.6" spread="7.42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Chemistry Parameter: ALT, AST,ALP</title>
        <description>Blood samples were collected to analyze the chemistry parameter: ALT, AST,ALP. Day -2was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Chemistry Parameter: ALT, AST,ALP</title>
          <description>Blood samples were collected to analyze the chemistry parameter: ALT, AST,ALP. Day -2was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>International units per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>ALT, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.2" spread="5.08"/>
                    <measurement group_id="O2" value="1.0" spread="4.56"/>
                    <measurement group_id="O3" value="0.5" spread="3.43"/>
                    <measurement group_id="O4" value="1.7" spread="2.63"/>
                    <measurement group_id="O5" value="-0.4" spread="3.71"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0" spread="5.44"/>
                    <measurement group_id="O2" value="-1.3" spread="6.35"/>
                    <measurement group_id="O3" value="1.4" spread="4.66"/>
                    <measurement group_id="O4" value="3.4" spread="5.32"/>
                    <measurement group_id="O5" value="0.3" spread="4.01"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.2" spread="6.55"/>
                    <measurement group_id="O2" value="-0.2" spread="7.86"/>
                    <measurement group_id="O3" value="0.9" spread="4.95"/>
                    <measurement group_id="O4" value="0.3" spread="4.07"/>
                    <measurement group_id="O5" value="0.9" spread="7.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.0" spread="7.62"/>
                    <measurement group_id="O2" value="-6.4" spread="9.66"/>
                    <measurement group_id="O3" value="1.8" spread="6.22"/>
                    <measurement group_id="O4" value="1.7" spread="4.68"/>
                    <measurement group_id="O5" value="-0.4" spread="7.51"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.2" spread="8.04"/>
                    <measurement group_id="O2" value="0.8" spread="11.75"/>
                    <measurement group_id="O3" value="3.5" spread="6.85"/>
                    <measurement group_id="O4" value="0.7" spread="4.89"/>
                    <measurement group_id="O5" value="0.4" spread="11.55"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.8" spread="10.85"/>
                    <measurement group_id="O2" value="1.8" spread="13.76"/>
                    <measurement group_id="O3" value="1.8" spread="6.08"/>
                    <measurement group_id="O4" value="0.1" spread="4.49"/>
                    <measurement group_id="O5" value="-0.4" spread="14.70"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, Day 14, predose, n=5,5,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.4" spread="9.26"/>
                    <measurement group_id="O2" value="-2.6" spread="12.97"/>
                    <measurement group_id="O3" value="2.6" spread="6.37"/>
                    <measurement group_id="O4" value="-1.0" spread="4.10"/>
                    <measurement group_id="O5" value="-1.2" spread="13.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.8" spread="15.54"/>
                    <measurement group_id="O2" value="1.7" spread="13.69"/>
                    <measurement group_id="O3" value="3.7" spread="6.19"/>
                    <measurement group_id="O4" value="-0.3" spread="3.50"/>
                    <measurement group_id="O5" value="1.0" spread="13.94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.0" spread="10.35"/>
                    <measurement group_id="O2" value="-0.3" spread="13.34"/>
                    <measurement group_id="O3" value="3.9" spread="6.98"/>
                    <measurement group_id="O4" value="1.8" spread="6.85"/>
                    <measurement group_id="O5" value="1.1" spread="15.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALT, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.5" spread="5.09"/>
                    <measurement group_id="O2" value="7.0" spread="20.39"/>
                    <measurement group_id="O3" value="4.6" spread="9.22"/>
                    <measurement group_id="O4" value="-1.3" spread="3.30"/>
                    <measurement group_id="O5" value="0.3" spread="8.41"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.7" spread="1.37"/>
                    <measurement group_id="O2" value="-3.7" spread="4.97"/>
                    <measurement group_id="O3" value="-0.9" spread="4.66"/>
                    <measurement group_id="O4" value="-0.1" spread="3.67"/>
                    <measurement group_id="O5" value="-2.3" spread="5.74"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.7" spread="3.67"/>
                    <measurement group_id="O2" value="-7.2" spread="5.23"/>
                    <measurement group_id="O3" value="0.3" spread="5.01"/>
                    <measurement group_id="O4" value="1.6" spread="6.75"/>
                    <measurement group_id="O5" value="-2.1" spread="4.31"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="7.28"/>
                    <measurement group_id="O2" value="-5.2" spread="4.62"/>
                    <measurement group_id="O3" value="0.3" spread="5.41"/>
                    <measurement group_id="O4" value="0.9" spread="5.52"/>
                    <measurement group_id="O5" value="-0.6" spread="4.88"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, Day 8 predose, n=6,5,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.0" spread="4.52"/>
                    <measurement group_id="O2" value="-4.4" spread="4.51"/>
                    <measurement group_id="O3" value="-0.1" spread="5.33"/>
                    <measurement group_id="O4" value="-0.4" spread="7.41"/>
                    <measurement group_id="O5" value="-1.4" spread="5.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.8" spread="4.92"/>
                    <measurement group_id="O2" value="-6.2" spread="3.19"/>
                    <measurement group_id="O3" value="-0.3" spread="5.53"/>
                    <measurement group_id="O4" value="-1.0" spread="8.85"/>
                    <measurement group_id="O5" value="-1.2" spread="5.94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.2" spread="3.92"/>
                    <measurement group_id="O2" value="-5.7" spread="3.39"/>
                    <measurement group_id="O3" value="0.2" spread="5.80"/>
                    <measurement group_id="O4" value="-0.1" spread="11.44"/>
                    <measurement group_id="O5" value="-1.4" spread="6.12"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, Day 14, predose, n=5,5,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.6" spread="7.13"/>
                    <measurement group_id="O2" value="-8.8" spread="6.10"/>
                    <measurement group_id="O3" value="-2.2" spread="4.87"/>
                    <measurement group_id="O4" value="0.8" spread="3.19"/>
                    <measurement group_id="O5" value="-4.2" spread="6.17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.3" spread="4.93"/>
                    <measurement group_id="O2" value="-6.0" spread="4.73"/>
                    <measurement group_id="O3" value="-1.6" spread="5.06"/>
                    <measurement group_id="O4" value="1.2" spread="5.53"/>
                    <measurement group_id="O5" value="-1.5" spread="6.02"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.7" spread="5.13"/>
                    <measurement group_id="O2" value="-6.8" spread="6.01"/>
                    <measurement group_id="O3" value="-1.8" spread="5.67"/>
                    <measurement group_id="O4" value="1.2" spread="3.31"/>
                    <measurement group_id="O5" value="-1.3" spread="6.09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>ALP, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread="5.75"/>
                    <measurement group_id="O2" value="-6.2" spread="5.91"/>
                    <measurement group_id="O3" value="-2.4" spread="5.41"/>
                    <measurement group_id="O4" value="-2.4" spread="8.36"/>
                    <measurement group_id="O5" value="-1.9" spread="7.29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, Day 2, predose, n=5,6,24,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.4" spread="3.58"/>
                    <measurement group_id="O2" value="-1.2" spread="2.79"/>
                    <measurement group_id="O3" value="-1.5" spread="3.51"/>
                    <measurement group_id="O4" value="-1.3" spread="4.89"/>
                    <measurement group_id="O5" value="-2.5" spread="3.01"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, Day 4, predose, n=5,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.6" spread="2.88"/>
                    <measurement group_id="O2" value="-3.0" spread="3.10"/>
                    <measurement group_id="O3" value="-1.4" spread="4.22"/>
                    <measurement group_id="O4" value="-2.4" spread="4.24"/>
                    <measurement group_id="O5" value="-1.5" spread="4.29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, Day 6, predose, n=5,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0" spread="4.18"/>
                    <measurement group_id="O2" value="-1.3" spread="3.88"/>
                    <measurement group_id="O3" value="-1.7" spread="3.79"/>
                    <measurement group_id="O4" value="-3.6" spread="2.94"/>
                    <measurement group_id="O5" value="-1.9" spread="5.40"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, Day 8 predose, n=5,5,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.6" spread="4.34"/>
                    <measurement group_id="O2" value="-6.4" spread="4.04"/>
                    <measurement group_id="O3" value="-0.8" spread="4.64"/>
                    <measurement group_id="O4" value="-3.1" spread="4.06"/>
                    <measurement group_id="O5" value="-1.1" spread="6.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, Day 10, predose, n=5,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0" spread="3.24"/>
                    <measurement group_id="O2" value="-2.8" spread="3.60"/>
                    <measurement group_id="O3" value="-1.6" spread="4.24"/>
                    <measurement group_id="O4" value="-3.6" spread="3.15"/>
                    <measurement group_id="O5" value="-1.5" spread="7.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, Day 12, predose, n=5,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.2" spread="4.32"/>
                    <measurement group_id="O2" value="-3.3" spread="5.09"/>
                    <measurement group_id="O3" value="-2.0" spread="4.63"/>
                    <measurement group_id="O4" value="-4.1" spread="4.38"/>
                    <measurement group_id="O5" value="-1.6" spread="7.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, Day 14, predose, n=4,5,23,5,12</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="23"/>
                    <count group_id="O4" value="5"/>
                    <count group_id="O5" value="12"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.8" spread="3.30"/>
                    <measurement group_id="O2" value="-5.6" spread="6.02"/>
                    <measurement group_id="O3" value="-2.0" spread="3.42"/>
                    <measurement group_id="O4" value="-1.6" spread="5.68"/>
                    <measurement group_id="O5" value="-2.8" spread="7.38"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, Day 14, 48 hours, n=5,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.8" spread="4.44"/>
                    <measurement group_id="O2" value="-3.0" spread="4.69"/>
                    <measurement group_id="O3" value="-1.8" spread="3.95"/>
                    <measurement group_id="O4" value="-3.5" spread="2.88"/>
                    <measurement group_id="O5" value="-2.4" spread="7.67"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, Day 14, 96 hours, n=5,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.4" spread="4.22"/>
                    <measurement group_id="O2" value="-2.8" spread="4.45"/>
                    <measurement group_id="O3" value="-2.0" spread="3.93"/>
                    <measurement group_id="O4" value="-2.2" spread="6.43"/>
                    <measurement group_id="O5" value="-1.2" spread="9.22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>AST, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.0" spread="6.67"/>
                    <measurement group_id="O2" value="2.5" spread="5.89"/>
                    <measurement group_id="O3" value="2.8" spread="5.75"/>
                    <measurement group_id="O4" value="0.6" spread="6.55"/>
                    <measurement group_id="O5" value="0.7" spread="4.70"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 1: Change From Baseline in Bicarbonate, Calcium, Chloride, Cholesterol, Magnesium, Phosphate, Potassium, Sodium, Urea</title>
        <description>Blood samples were collected to analyze the chemistry parameter: bicarbonate, calcium, chloride, magnesium, phosphate, potassium, sodium, urea. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
        <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Change From Baseline in Bicarbonate, Calcium, Chloride, Cholesterol, Magnesium, Phosphate, Potassium, Sodium, Urea</title>
          <description>Blood samples were collected to analyze the chemistry parameter: bicarbonate, calcium, chloride, magnesium, phosphate, potassium, sodium, urea. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Millimoles per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Bicarbonate, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="2.80"/>
                    <measurement group_id="O2" value="-1.3" spread="2.07"/>
                    <measurement group_id="O3" value="0.2" spread="2.31"/>
                    <measurement group_id="O4" value="1.1" spread="1.57"/>
                    <measurement group_id="O5" value="0.4" spread="1.95"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="1.72"/>
                    <measurement group_id="O2" value="-3.3" spread="1.97"/>
                    <measurement group_id="O3" value="1.0" spread="2.23"/>
                    <measurement group_id="O4" value="3.1" spread="3.08"/>
                    <measurement group_id="O5" value="2.1" spread="2.09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.2" spread="2.40"/>
                    <measurement group_id="O2" value="-4.5" spread="1.22"/>
                    <measurement group_id="O3" value="1.0" spread="2.17"/>
                    <measurement group_id="O4" value="0.4" spread="1.81"/>
                    <measurement group_id="O5" value="1.8" spread="1.72"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.7" spread="1.86"/>
                    <measurement group_id="O2" value="-1.5" spread="1.87"/>
                    <measurement group_id="O3" value="1.0" spread="1.63"/>
                    <measurement group_id="O4" value="1.3" spread="1.70"/>
                    <measurement group_id="O5" value="1.6" spread="1.91"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.5" spread="2.81"/>
                    <measurement group_id="O2" value="-0.2" spread="1.72"/>
                    <measurement group_id="O3" value="2.4" spread="3.29"/>
                    <measurement group_id="O4" value="2.0" spread="1.63"/>
                    <measurement group_id="O5" value="2.4" spread="2.24"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.8" spread="1.60"/>
                    <measurement group_id="O2" value="-0.5" spread="1.64"/>
                    <measurement group_id="O3" value="1.3" spread="2.17"/>
                    <measurement group_id="O4" value="3.4" spread="2.82"/>
                    <measurement group_id="O5" value="1.6" spread="1.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, Day 14, predose, n=6,6,25,6,12</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="12"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.2" spread="0.98"/>
                    <measurement group_id="O2" value="-1.2" spread="1.72"/>
                    <measurement group_id="O3" value="0.1" spread="1.93"/>
                    <measurement group_id="O4" value="1.5" spread="1.05"/>
                    <measurement group_id="O5" value="1.0" spread="1.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.2" spread="1.47"/>
                    <measurement group_id="O2" value="0.8" spread="0.98"/>
                    <measurement group_id="O3" value="2.2" spread="2.30"/>
                    <measurement group_id="O4" value="2.5" spread="3.56"/>
                    <measurement group_id="O5" value="3.0" spread="2.11"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.2" spread="1.72"/>
                    <measurement group_id="O2" value="1.0" spread="1.67"/>
                    <measurement group_id="O3" value="1.7" spread="1.55"/>
                    <measurement group_id="O4" value="4.3" spread="2.16"/>
                    <measurement group_id="O5" value="2.3" spread="2.05"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bicarbonate, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.3" spread="2.94"/>
                    <measurement group_id="O2" value="-1.0" spread="0.63"/>
                    <measurement group_id="O3" value="0.3" spread="2.50"/>
                    <measurement group_id="O4" value="2.3" spread="2.56"/>
                    <measurement group_id="O5" value="0.8" spread="1.72"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.005" spread="0.0497"/>
                    <measurement group_id="O2" value="0.012" spread="0.0354"/>
                    <measurement group_id="O3" value="0.003" spread="0.0701"/>
                    <measurement group_id="O4" value="0.104" spread="0.0627"/>
                    <measurement group_id="O5" value="0.003" spread="0.0722"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.022" spread="0.0791"/>
                    <measurement group_id="O2" value="0.010" spread="0.0385"/>
                    <measurement group_id="O3" value="0.013" spread="0.0580"/>
                    <measurement group_id="O4" value="0.117" spread="0.0574"/>
                    <measurement group_id="O5" value="0.030" spread="0.0479"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.028" spread="0.1063"/>
                    <measurement group_id="O2" value="0.003" spread="0.0505"/>
                    <measurement group_id="O3" value="-0.020" spread="0.0607"/>
                    <measurement group_id="O4" value="0.083" spread="0.0512"/>
                    <measurement group_id="O5" value="0.011" spread="0.0578"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.005" spread="0.0528"/>
                    <measurement group_id="O2" value="0.003" spread="0.0378"/>
                    <measurement group_id="O3" value="0.006" spread="0.0575"/>
                    <measurement group_id="O4" value="0.074" spread="0.0387"/>
                    <measurement group_id="O5" value="0.028" spread="0.0641"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.000" spread="0.0890"/>
                    <measurement group_id="O2" value="0.017" spread="0.0408"/>
                    <measurement group_id="O3" value="0.014" spread="0.0699"/>
                    <measurement group_id="O4" value="0.079" spread="0.0763"/>
                    <measurement group_id="O5" value="0.024" spread="0.0628"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.063" spread="0.0619"/>
                    <measurement group_id="O2" value="-0.010" spread="0.0551"/>
                    <measurement group_id="O3" value="0.024" spread="0.0667"/>
                    <measurement group_id="O4" value="0.066" spread="0.0608"/>
                    <measurement group_id="O5" value="0.025" spread="0.0617"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, Day 14, predose, n=6,6,25,6,12</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="12"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.063" spread="0.0779"/>
                    <measurement group_id="O2" value="-0.034" spread="0.0404"/>
                    <measurement group_id="O3" value="-0.015" spread="0.0843"/>
                    <measurement group_id="O4" value="0.028" spread="0.0512"/>
                    <measurement group_id="O5" value="0.008" spread="0.0715"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.017" spread="0.0592"/>
                    <measurement group_id="O2" value="0.012" spread="0.0462"/>
                    <measurement group_id="O3" value="0.035" spread="0.0566"/>
                    <measurement group_id="O4" value="0.072" spread="0.0806"/>
                    <measurement group_id="O5" value="0.033" spread="0.0770"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.005" spread="0.0459"/>
                    <measurement group_id="O2" value="0.027" spread="0.0472"/>
                    <measurement group_id="O3" value="0.037" spread="0.0526"/>
                    <measurement group_id="O4" value="0.078" spread="0.1042"/>
                    <measurement group_id="O5" value="0.046" spread="0.0580"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Calcium, FU(Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.042" spread="0.0471"/>
                    <measurement group_id="O2" value="0.003" spread="0.0550"/>
                    <measurement group_id="O3" value="-0.018" spread="0.0572"/>
                    <measurement group_id="O4" value="0.039" spread="0.0891"/>
                    <measurement group_id="O5" value="0.019" spread="0.0827"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="1.03"/>
                    <measurement group_id="O2" value="2.0" spread="2.10"/>
                    <measurement group_id="O3" value="0.4" spread="1.45"/>
                    <measurement group_id="O4" value="-0.1" spread="1.57"/>
                    <measurement group_id="O5" value="1.1" spread="1.98"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="1.63"/>
                    <measurement group_id="O2" value="2.3" spread="1.63"/>
                    <measurement group_id="O3" value="0.1" spread="1.72"/>
                    <measurement group_id="O4" value="0.0" spread="2.45"/>
                    <measurement group_id="O5" value="0.9" spread="1.90"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.2" spread="1.17"/>
                    <measurement group_id="O2" value="0.7" spread="1.21"/>
                    <measurement group_id="O3" value="0.2" spread="2.01"/>
                    <measurement group_id="O4" value="0.4" spread="1.40"/>
                    <measurement group_id="O5" value="0.4" spread="2.10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.5" spread="1.38"/>
                    <measurement group_id="O2" value="1.8" spread="1.33"/>
                    <measurement group_id="O3" value="-0.2" spread="1.67"/>
                    <measurement group_id="O4" value="1.3" spread="1.70"/>
                    <measurement group_id="O5" value="0.6" spread="2.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.0" spread="1.41"/>
                    <measurement group_id="O2" value="1.7" spread="1.03"/>
                    <measurement group_id="O3" value="0.0" spread="1.99"/>
                    <measurement group_id="O4" value="0.7" spread="2.43"/>
                    <measurement group_id="O5" value="0.7" spread="1.77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.3" spread="1.75"/>
                    <measurement group_id="O2" value="2.0" spread="1.26"/>
                    <measurement group_id="O3" value="0.8" spread="1.80"/>
                    <measurement group_id="O4" value="0.7" spread="2.29"/>
                    <measurement group_id="O5" value="1.3" spread="2.23"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, Day 14, predose, n=6,6,25,6,12</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="12"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="2.14"/>
                    <measurement group_id="O2" value="2.2" spread="1.17"/>
                    <measurement group_id="O3" value="0.9" spread="2.12"/>
                    <measurement group_id="O4" value="0.2" spread="1.47"/>
                    <measurement group_id="O5" value="1.0" spread="2.11"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.2" spread="1.72"/>
                    <measurement group_id="O2" value="1.0" spread="1.41"/>
                    <measurement group_id="O3" value="1.0" spread="1.76"/>
                    <measurement group_id="O4" value="1.0" spread="2.53"/>
                    <measurement group_id="O5" value="1.1" spread="2.37"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.0" spread="0.00"/>
                    <measurement group_id="O2" value="2.8" spread="1.33"/>
                    <measurement group_id="O3" value="0.6" spread="1.71"/>
                    <measurement group_id="O4" value="-0.5" spread="1.87"/>
                    <measurement group_id="O5" value="0.5" spread="2.21"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Chloride, FU(Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.3" spread="1.21"/>
                    <measurement group_id="O2" value="0.5" spread="1.38"/>
                    <measurement group_id="O3" value="0.4" spread="1.55"/>
                    <measurement group_id="O4" value="0.3" spread="2.43"/>
                    <measurement group_id="O5" value="0.8" spread="1.89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.055" spread="0.0596"/>
                    <measurement group_id="O2" value="-0.012" spread="0.0436"/>
                    <measurement group_id="O3" value="-0.004" spread="0.0486"/>
                    <measurement group_id="O4" value="0.016" spread="0.0624"/>
                    <measurement group_id="O5" value="-0.006" spread="0.0422"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.063" spread="0.0472"/>
                    <measurement group_id="O2" value="-0.027" spread="0.0520"/>
                    <measurement group_id="O3" value="0.005" spread="0.0415"/>
                    <measurement group_id="O4" value="0.027" spread="0.0577"/>
                    <measurement group_id="O5" value="0.007" spread="0.0347"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.053" spread="0.0388"/>
                    <measurement group_id="O2" value="-0.027" spread="0.0589"/>
                    <measurement group_id="O3" value="0.019" spread="0.0476"/>
                    <measurement group_id="O4" value="0.017" spread="0.0399"/>
                    <measurement group_id="O5" value="0.008" spread="0.0556"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.075" spread="0.0532"/>
                    <measurement group_id="O2" value="0.000" spread="0.0420"/>
                    <measurement group_id="O3" value="0.002" spread="0.0426"/>
                    <measurement group_id="O4" value="0.019" spread="0.0438"/>
                    <measurement group_id="O5" value="0.004" spread="0.0420"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.047" spread="0.0543"/>
                    <measurement group_id="O2" value="-0.003" spread="0.0361"/>
                    <measurement group_id="O3" value="0.018" spread="0.0472"/>
                    <measurement group_id="O4" value="0.017" spread="0.0390"/>
                    <measurement group_id="O5" value="0.000" spread="0.0566"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.038" spread="0.0585"/>
                    <measurement group_id="O2" value="0.013" spread="0.0505"/>
                    <measurement group_id="O3" value="0.014" spread="0.0401"/>
                    <measurement group_id="O4" value="0.007" spread="0.0446"/>
                    <measurement group_id="O5" value="0.004" spread="0.0390"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, Day 14, predose, n=5,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.030" spread="0.0495"/>
                    <measurement group_id="O2" value="-0.013" spread="0.0653"/>
                    <measurement group_id="O3" value="0.019" spread="0.0473"/>
                    <measurement group_id="O4" value="-0.002" spread="0.0343"/>
                    <measurement group_id="O5" value="-0.001" spread="0.0551"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.040" spread="0.0555"/>
                    <measurement group_id="O2" value="-0.022" spread="0.0445"/>
                    <measurement group_id="O3" value="0.011" spread="0.0355"/>
                    <measurement group_id="O4" value="0.020" spread="0.0603"/>
                    <measurement group_id="O5" value="-0.001" spread="0.0363"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.025" spread="0.0485"/>
                    <measurement group_id="O2" value="-0.007" spread="0.0423"/>
                    <measurement group_id="O3" value="0.011" spread="0.0360"/>
                    <measurement group_id="O4" value="0.022" spread="0.0331"/>
                    <measurement group_id="O5" value="-0.002" spread="0.0662"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Magnesium, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.037" spread="0.0509"/>
                    <measurement group_id="O2" value="-0.027" spread="0.0589"/>
                    <measurement group_id="O3" value="0.001" spread="0.0387"/>
                    <measurement group_id="O4" value="-0.003" spread="0.0415"/>
                    <measurement group_id="O5" value="-0.009" spread="0.0469"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.068" spread="0.1636"/>
                    <measurement group_id="O2" value="0.062" spread="0.0760"/>
                    <measurement group_id="O3" value="-0.024" spread="0.1248"/>
                    <measurement group_id="O4" value="0.086" spread="0.1585"/>
                    <measurement group_id="O5" value="0.035" spread="0.2069"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.057" spread="0.1091"/>
                    <measurement group_id="O2" value="0.017" spread="0.1237"/>
                    <measurement group_id="O3" value="-0.003" spread="0.1382"/>
                    <measurement group_id="O4" value="0.057" spread="0.1045"/>
                    <measurement group_id="O5" value="0.036" spread="0.1835"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.100" spread="0.1324"/>
                    <measurement group_id="O2" value="0.038" spread="0.1080"/>
                    <measurement group_id="O3" value="-0.014" spread="0.1375"/>
                    <measurement group_id="O4" value="0.164" spread="0.1018"/>
                    <measurement group_id="O5" value="0.060" spread="0.2119"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.150" spread="0.1145"/>
                    <measurement group_id="O2" value="0.075" spread="0.1140"/>
                    <measurement group_id="O3" value="0.021" spread="0.1285"/>
                    <measurement group_id="O4" value="0.121" spread="0.1644"/>
                    <measurement group_id="O5" value="0.074" spread="0.2112"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.150" spread="0.1848"/>
                    <measurement group_id="O2" value="0.118" spread="0.0937"/>
                    <measurement group_id="O3" value="0.061" spread="0.1372"/>
                    <measurement group_id="O4" value="0.140" spread="0.1344"/>
                    <measurement group_id="O5" value="0.129" spread="0.1626"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.155" spread="0.1428"/>
                    <measurement group_id="O2" value="0.090" spread="0.0827"/>
                    <measurement group_id="O3" value="0.085" spread="0.1704"/>
                    <measurement group_id="O4" value="0.193" spread="0.1329"/>
                    <measurement group_id="O5" value="0.139" spread="0.2000"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, Day 14, predose, n=5,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.212" spread="0.1587"/>
                    <measurement group_id="O2" value="0.087" spread="0.1388"/>
                    <measurement group_id="O3" value="0.043" spread="0.1363"/>
                    <measurement group_id="O4" value="0.170" spread="0.1030"/>
                    <measurement group_id="O5" value="0.101" spread="0.2161"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.208" spread="0.1382"/>
                    <measurement group_id="O2" value="0.063" spread="0.1516"/>
                    <measurement group_id="O3" value="0.093" spread="0.1517"/>
                    <measurement group_id="O4" value="0.052" spread="0.1446"/>
                    <measurement group_id="O5" value="0.082" spread="0.1873"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.178" spread="0.1869"/>
                    <measurement group_id="O2" value="0.140" spread="0.1255"/>
                    <measurement group_id="O3" value="0.089" spread="0.1510"/>
                    <measurement group_id="O4" value="0.085" spread="0.1536"/>
                    <measurement group_id="O5" value="0.119" spread="0.2051"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Phosphate, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.013" spread="0.1363"/>
                    <measurement group_id="O2" value="-0.020" spread="0.1418"/>
                    <measurement group_id="O3" value="-0.047" spread="0.1837"/>
                    <measurement group_id="O4" value="0.010" spread="0.1795"/>
                    <measurement group_id="O5" value="0.010" spread="0.1741"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.10" spread="0.390"/>
                    <measurement group_id="O2" value="-0.10" spread="0.190"/>
                    <measurement group_id="O3" value="0.12" spread="0.340"/>
                    <measurement group_id="O4" value="0.41" spread="0.662"/>
                    <measurement group_id="O5" value="0.14" spread="0.203"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.28" spread="0.279"/>
                    <measurement group_id="O2" value="-0.07" spread="0.216"/>
                    <measurement group_id="O3" value="0.17" spread="0.369"/>
                    <measurement group_id="O4" value="0.20" spread="0.383"/>
                    <measurement group_id="O5" value="0.19" spread="0.141"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.30" spread="0.529"/>
                    <measurement group_id="O2" value="0.12" spread="0.264"/>
                    <measurement group_id="O3" value="0.11" spread="0.396"/>
                    <measurement group_id="O4" value="0.21" spread="0.285"/>
                    <measurement group_id="O5" value="0.06" spread="0.234"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, Day 8 predose, n=6,5,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.23" spread="0.216"/>
                    <measurement group_id="O2" value="-0.06" spread="0.152"/>
                    <measurement group_id="O3" value="0.04" spread="0.364"/>
                    <measurement group_id="O4" value="0.20" spread="0.374"/>
                    <measurement group_id="O5" value="0.17" spread="0.307"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.32" spread="0.519"/>
                    <measurement group_id="O2" value="-0.08" spread="0.194"/>
                    <measurement group_id="O3" value="0.06" spread="0.406"/>
                    <measurement group_id="O4" value="0.21" spread="0.358"/>
                    <measurement group_id="O5" value="0.09" spread="0.138"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.38" spread="0.431"/>
                    <measurement group_id="O2" value="-0.13" spread="0.280"/>
                    <measurement group_id="O3" value="0.08" spread="0.384"/>
                    <measurement group_id="O4" value="0.17" spread="0.399"/>
                    <measurement group_id="O5" value="0.22" spread="0.176"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, Day 14, predose, n=5,5,24,6,13</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="5"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="13"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.12" spread="0.277"/>
                    <measurement group_id="O2" value="-0.20" spread="0.300"/>
                    <measurement group_id="O3" value="-0.06" spread="0.388"/>
                    <measurement group_id="O4" value="-0.05" spread="0.327"/>
                    <measurement group_id="O5" value="0.19" spread="0.348"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.27" spread="0.509"/>
                    <measurement group_id="O2" value="-0.18" spread="0.204"/>
                    <measurement group_id="O3" value="0.07" spread="0.338"/>
                    <measurement group_id="O4" value="-0.08" spread="0.331"/>
                    <measurement group_id="O5" value="0.04" spread="0.214"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.07" spread="0.333"/>
                    <measurement group_id="O2" value="-0.13" spread="0.137"/>
                    <measurement group_id="O3" value="0.00" spread="0.393"/>
                    <measurement group_id="O4" value="0.08" spread="0.172"/>
                    <measurement group_id="O5" value="0.13" spread="0.261"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Potassium, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.05" spread="0.383"/>
                    <measurement group_id="O2" value="-0.08" spread="0.160"/>
                    <measurement group_id="O3" value="-0.06" spread="0.347"/>
                    <measurement group_id="O4" value="-0.13" spread="0.335"/>
                    <measurement group_id="O5" value="0.21" spread="0.530"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.2" spread="1.47"/>
                    <measurement group_id="O2" value="1.2" spread="1.47"/>
                    <measurement group_id="O3" value="-0.5" spread="1.48"/>
                    <measurement group_id="O4" value="-1.1" spread="1.86"/>
                    <measurement group_id="O5" value="0.1" spread="2.11"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread="1.87"/>
                    <measurement group_id="O2" value="1.5" spread="1.38"/>
                    <measurement group_id="O3" value="-0.3" spread="1.17"/>
                    <measurement group_id="O4" value="0.9" spread="1.77"/>
                    <measurement group_id="O5" value="0.8" spread="1.93"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="1.21"/>
                    <measurement group_id="O2" value="1.2" spread="1.17"/>
                    <measurement group_id="O3" value="-0.7" spread="1.14"/>
                    <measurement group_id="O4" value="-0.1" spread="1.07"/>
                    <measurement group_id="O5" value="0.5" spread="1.70"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.5" spread="1.38"/>
                    <measurement group_id="O2" value="1.8" spread="0.75"/>
                    <measurement group_id="O3" value="-1.0" spread="1.15"/>
                    <measurement group_id="O4" value="0.4" spread="1.40"/>
                    <measurement group_id="O5" value="0.7" spread="2.16"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread="1.22"/>
                    <measurement group_id="O2" value="2.8" spread="0.98"/>
                    <measurement group_id="O3" value="0.3" spread="2.10"/>
                    <measurement group_id="O4" value="1.0" spread="1.63"/>
                    <measurement group_id="O5" value="0.9" spread="2.07"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.2" spread="0.98"/>
                    <measurement group_id="O2" value="1.7" spread="1.03"/>
                    <measurement group_id="O3" value="0.2" spread="1.53"/>
                    <measurement group_id="O4" value="0.9" spread="1.57"/>
                    <measurement group_id="O5" value="1.2" spread="1.89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.5" spread="1.52"/>
                    <measurement group_id="O2" value="2.2" spread="1.17"/>
                    <measurement group_id="O3" value="-1.1" spread="1.83"/>
                    <measurement group_id="O4" value="-0.5" spread="0.55"/>
                    <measurement group_id="O5" value="0.1" spread="2.34"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="1.75"/>
                    <measurement group_id="O2" value="1.0" spread="0.89"/>
                    <measurement group_id="O3" value="0.4" spread="1.35"/>
                    <measurement group_id="O4" value="0.5" spread="0.84"/>
                    <measurement group_id="O5" value="1.3" spread="2.27"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread="1.52"/>
                    <measurement group_id="O2" value="2.3" spread="0.82"/>
                    <measurement group_id="O3" value="0.6" spread="1.59"/>
                    <measurement group_id="O4" value="0.3" spread="1.03"/>
                    <measurement group_id="O5" value="1.1" spread="2.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Sodium, FU(Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="2.48"/>
                    <measurement group_id="O2" value="0.8" spread="1.72"/>
                    <measurement group_id="O3" value="-0.1" spread="1.58"/>
                    <measurement group_id="O4" value="0.0" spread="1.73"/>
                    <measurement group_id="O5" value="0.9" spread="2.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.583100" spread="1.7190989"/>
                    <measurement group_id="O2" value="-0.383180" spread="0.8994549"/>
                    <measurement group_id="O3" value="-0.279888" spread="1.3039577"/>
                    <measurement group_id="O4" value="0.242760" spread="0.8615469"/>
                    <measurement group_id="O5" value="-0.221340" spread="1.0565530"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.982940" spread="2.0645229"/>
                    <measurement group_id="O2" value="-0.616420" spread="0.8994549"/>
                    <measurement group_id="O3" value="-0.415834" spread="1.2169831"/>
                    <measurement group_id="O4" value="-0.157080" spread="0.7761282"/>
                    <measurement group_id="O5" value="-0.535500" spread="1.2302718"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.533120" spread="1.6805969"/>
                    <measurement group_id="O2" value="-0.566440" spread="1.0685283"/>
                    <measurement group_id="O3" value="-0.439824" spread="1.3090563"/>
                    <measurement group_id="O4" value="-0.414120" spread="0.8948673"/>
                    <measurement group_id="O5" value="-0.606900" spread="1.0361954"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.716380" spread="1.4324888"/>
                    <measurement group_id="O2" value="-0.982940" spread="1.2427511"/>
                    <measurement group_id="O3" value="-0.287885" spread="1.1923207"/>
                    <measurement group_id="O4" value="-0.257040" spread="0.7543661"/>
                    <measurement group_id="O5" value="-0.249900" spread="1.2544880"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.866320" spread="1.6805969"/>
                    <measurement group_id="O2" value="-0.066640" spread="0.8843306"/>
                    <measurement group_id="O3" value="-0.491803" spread="1.1108310"/>
                    <measurement group_id="O4" value="-0.842520" spread="0.7064873"/>
                    <measurement group_id="O5" value="-0.207060" spread="1.4392234"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.032920" spread="1.7088970"/>
                    <measurement group_id="O2" value="-0.466480" spread="1.1821793"/>
                    <measurement group_id="O3" value="-0.139944" spread="1.1809813"/>
                    <measurement group_id="O4" value="-1.013880" spread="0.9698843"/>
                    <measurement group_id="O5" value="-0.399840" spread="1.2423284"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.049580" spread="1.9204291"/>
                    <measurement group_id="O2" value="-1.166200" spread="1.6051804"/>
                    <measurement group_id="O3" value="-0.399840" spread="1.2290067"/>
                    <measurement group_id="O4" value="-0.882980" spread="0.9192335"/>
                    <measurement group_id="O5" value="-0.271320" spread="1.2493792"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.916300" spread="1.5165176"/>
                    <measurement group_id="O2" value="-0.533120" spread="1.2237107"/>
                    <measurement group_id="O3" value="-0.703885" spread="1.1463627"/>
                    <measurement group_id="O4" value="-0.949620" spread="1.1991034"/>
                    <measurement group_id="O5" value="-0.521220" spread="1.4681527"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.949620" spread="1.5674926"/>
                    <measurement group_id="O2" value="-0.483140" spread="0.9278887"/>
                    <measurement group_id="O3" value="-0.749700" spread="1.1904312"/>
                    <measurement group_id="O4" value="-0.499800" spread="0.8387115"/>
                    <measurement group_id="O5" value="-0.556920" spread="1.1341178"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Urea, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.882980" spread="1.2603155"/>
                    <measurement group_id="O2" value="-1.166200" spread="0.9580876"/>
                    <measurement group_id="O3" value="-0.411835" spread="1.0341231"/>
                    <measurement group_id="O4" value="-0.571200" spread="0.6208106"/>
                    <measurement group_id="O5" value="-0.778260" spread="0.9818953"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Cholesterol, HDL Cholesterol, LDL Cholesterol, Triglycerides</title>
        <description>Blood samples were collected at indicated time points to analyze the chemistry parameter: cholesterol, HDL cholesterol, LDL cholesterol, triglycerides. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), Day 8 (pre dose), Day 14 (48 hours) post dose and Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Cholesterol, HDL Cholesterol, LDL Cholesterol, Triglycerides</title>
          <description>Blood samples were collected at indicated time points to analyze the chemistry parameter: cholesterol, HDL cholesterol, LDL cholesterol, triglycerides. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Millimoles per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Cholesterol, Day 8, (predose) n=5,6,25,7,13</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="13"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.08" spread="0.192"/>
                    <measurement group_id="O2" value="0.07" spread="0.631"/>
                    <measurement group_id="O3" value="0.16" spread="0.466"/>
                    <measurement group_id="O4" value="0.36" spread="0.369"/>
                    <measurement group_id="O5" value="0.38" spread="0.440"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Cholesterol, Day 14 (48 hours), n= 6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.05" spread="0.373"/>
                    <measurement group_id="O2" value="0.23" spread="0.589"/>
                    <measurement group_id="O3" value="0.23" spread="0.531"/>
                    <measurement group_id="O4" value="0.40" spread="0.696"/>
                    <measurement group_id="O5" value="0.38" spread="0.647"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Cholesterol, FU (Day 28), n= 6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.28" spread="0.147"/>
                    <measurement group_id="O2" value="0.15" spread="0.619"/>
                    <measurement group_id="O3" value="-0.04" spread="0.461"/>
                    <measurement group_id="O4" value="-0.29" spread="0.955"/>
                    <measurement group_id="O5" value="-0.04" spread="0.434"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>HDL Cholesterol, Day 8, (predose) n=5,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.03" spread="0.121"/>
                    <measurement group_id="O2" value="0.00" spread="0.167"/>
                    <measurement group_id="O3" value="-0.14" spread="0.235"/>
                    <measurement group_id="O4" value="-0.13" spread="0.150"/>
                    <measurement group_id="O5" value="-0.14" spread="0.203"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>HDL Cholesterol, Day 14 (48 hours), n= 6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.08" spread="0.075"/>
                    <measurement group_id="O2" value="-0.10" spread="0.179"/>
                    <measurement group_id="O3" value="-0.18" spread="0.129"/>
                    <measurement group_id="O4" value="-0.08" spread="0.194"/>
                    <measurement group_id="O5" value="-0.20" spread="0.260"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>HDL Cholesterol, FU (Day 28), n= 6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.02" spread="0.041"/>
                    <measurement group_id="O2" value="0.00" spread="0.179"/>
                    <measurement group_id="O3" value="-0.12" spread="0.277"/>
                    <measurement group_id="O4" value="0.01" spread="0.372"/>
                    <measurement group_id="O5" value="-0.14" spread="0.195"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>LDL Cholesterol, Day 8, (predose) n=5,6,25,7,13</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="13"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.08" spread="0.217"/>
                    <measurement group_id="O2" value="0.03" spread="0.463"/>
                    <measurement group_id="O3" value="0.27" spread="0.407"/>
                    <measurement group_id="O4" value="0.49" spread="0.453"/>
                    <measurement group_id="O5" value="0.42" spread="0.420"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>LDL Cholesterol, Day 14 (48 hours), n= 6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.03" spread="0.234"/>
                    <measurement group_id="O2" value="0.27" spread="0.388"/>
                    <measurement group_id="O3" value="0.33" spread="0.442"/>
                    <measurement group_id="O4" value="0.33" spread="0.615"/>
                    <measurement group_id="O5" value="0.47" spread="0.517"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>LDL Cholesterol, FU (Day 28),n= 6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.23" spread="0.216"/>
                    <measurement group_id="O2" value="0.12" spread="0.556"/>
                    <measurement group_id="O3" value="0.12" spread="0.456"/>
                    <measurement group_id="O4" value="-0.33" spread="0.565"/>
                    <measurement group_id="O5" value="0.06" spread="0.455"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Triglycerides, Day 8, (predose) n=5,6,25,7,13</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="13"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.12" spread="0.492"/>
                    <measurement group_id="O2" value="0.07" spread="0.137"/>
                    <measurement group_id="O3" value="0.08" spread="0.314"/>
                    <measurement group_id="O4" value="-0.04" spread="0.424"/>
                    <measurement group_id="O5" value="0.22" spread="0.215"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Triglycerides, Day 14 (48 hours), n= 6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.20" spread="0.502"/>
                    <measurement group_id="O2" value="0.15" spread="0.266"/>
                    <measurement group_id="O3" value="0.18" spread="0.400"/>
                    <measurement group_id="O4" value="0.28" spread="0.479"/>
                    <measurement group_id="O5" value="0.26" spread="0.285"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Triglycerides, FU (Day 28), n= 6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.12" spread="0.471"/>
                    <measurement group_id="O2" value="0.07" spread="0.356"/>
                    <measurement group_id="O3" value="-0.06" spread="0.349"/>
                    <measurement group_id="O4" value="0.06" spread="0.538"/>
                    <measurement group_id="O5" value="0.14" spread="0.665"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Chemistry Parameter: Glucose</title>
        <description>Blood samples were collected at indicated time points to analyze the chemistry parameter: glucose . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), Day 8 (predose), Day 14 (48 hours) post dose and Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Chemistry Parameter: Glucose</title>
          <description>Blood samples were collected at indicated time points to analyze the chemistry parameter: glucose . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Millimoles per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 8, (predose) n=5,6,25,7,13</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="5"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="13"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.02" spread="0.550"/>
                    <measurement group_id="O2" value="0.20" spread="0.237"/>
                    <measurement group_id="O3" value="-0.10" spread="0.278"/>
                    <measurement group_id="O4" value="-0.09" spread="0.398"/>
                    <measurement group_id="O5" value="-0.12" spread="0.394"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14 (48 hours), n= 6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.15" spread="0.532"/>
                    <measurement group_id="O2" value="0.03" spread="0.350"/>
                    <measurement group_id="O3" value="-0.23" spread="0.275"/>
                    <measurement group_id="O4" value="0.00" spread="0.329"/>
                    <measurement group_id="O5" value="-0.21" spread="0.405"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 28), n= 6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.05" spread="0.824"/>
                    <measurement group_id="O2" value="0.15" spread="0.389"/>
                    <measurement group_id="O3" value="-0.12" spread="0.375"/>
                    <measurement group_id="O4" value="0.20" spread="0.507"/>
                    <measurement group_id="O5" value="-0.02" spread="0.458"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Chemistry Parameter: Bilirubin, Creatinine, Direct Bilirubin</title>
        <description>Blood samples were collected to analyze the chemistry parameter: bilirubin, creatinine, direct bilirubin . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Chemistry Parameter: Bilirubin, Creatinine, Direct Bilirubin</title>
          <description>Blood samples were collected to analyze the chemistry parameter: bilirubin, creatinine, direct bilirubin . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Micromoles per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Bilirubin, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.3" spread="1.97"/>
                    <measurement group_id="O2" value="-0.8" spread="2.14"/>
                    <measurement group_id="O3" value="-0.7" spread="4.03"/>
                    <measurement group_id="O4" value="-2.6" spread="2.94"/>
                    <measurement group_id="O5" value="-0.9" spread="4.01"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.5" spread="2.59"/>
                    <measurement group_id="O2" value="0.2" spread="0.98"/>
                    <measurement group_id="O3" value="-0.7" spread="3.53"/>
                    <measurement group_id="O4" value="0.3" spread="1.50"/>
                    <measurement group_id="O5" value="0.3" spread="3.50"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.8" spread="1.72"/>
                    <measurement group_id="O2" value="-2.2" spread="1.72"/>
                    <measurement group_id="O3" value="-1.0" spread="3.67"/>
                    <measurement group_id="O4" value="-1.1" spread="3.63"/>
                    <measurement group_id="O5" value="-0.7" spread="3.58"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.7" spread="2.07"/>
                    <measurement group_id="O2" value="-0.5" spread="1.38"/>
                    <measurement group_id="O3" value="-0.9" spread="3.73"/>
                    <measurement group_id="O4" value="-1.3" spread="3.64"/>
                    <measurement group_id="O5" value="-0.1" spread="3.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.8" spread="2.64"/>
                    <measurement group_id="O2" value="-0.2" spread="2.04"/>
                    <measurement group_id="O3" value="0.0" spread="3.52"/>
                    <measurement group_id="O4" value="-0.6" spread="4.20"/>
                    <measurement group_id="O5" value="-0.1" spread="3.41"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.8" spread="1.83"/>
                    <measurement group_id="O2" value="0.2" spread="2.48"/>
                    <measurement group_id="O3" value="-1.3" spread="3.31"/>
                    <measurement group_id="O4" value="-1.4" spread="3.69"/>
                    <measurement group_id="O5" value="-1.1" spread="3.17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="1.37"/>
                    <measurement group_id="O2" value="-0.3" spread="1.86"/>
                    <measurement group_id="O3" value="-1.0" spread="3.65"/>
                    <measurement group_id="O4" value="-1.8" spread="3.54"/>
                    <measurement group_id="O5" value="-0.4" spread="3.75"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.7" spread="2.07"/>
                    <measurement group_id="O2" value="1.2" spread="2.64"/>
                    <measurement group_id="O3" value="0.1" spread="3.71"/>
                    <measurement group_id="O4" value="-0.8" spread="3.60"/>
                    <measurement group_id="O5" value="0.0" spread="3.35"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.2" spread="1.17"/>
                    <measurement group_id="O2" value="1.0" spread="1.79"/>
                    <measurement group_id="O3" value="-0.4" spread="4.71"/>
                    <measurement group_id="O4" value="-1.0" spread="3.74"/>
                    <measurement group_id="O5" value="0.2" spread="4.02"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bilirubin, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.2" spread="2.04"/>
                    <measurement group_id="O2" value="1.8" spread="2.40"/>
                    <measurement group_id="O3" value="2.3" spread="7.28"/>
                    <measurement group_id="O4" value="0.6" spread="4.35"/>
                    <measurement group_id="O5" value="-0.1" spread="3.90"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="2.50"/>
                    <measurement group_id="O2" value="8.2" spread="3.87"/>
                    <measurement group_id="O3" value="-3.0" spread="5.30"/>
                    <measurement group_id="O4" value="6.1" spread="8.30"/>
                    <measurement group_id="O5" value="0.4" spread="3.23"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.7" spread="4.72"/>
                    <measurement group_id="O2" value="1.8" spread="3.43"/>
                    <measurement group_id="O3" value="1.9" spread="6.05"/>
                    <measurement group_id="O4" value="3.1" spread="3.24"/>
                    <measurement group_id="O5" value="1.4" spread="8.90"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="5.72"/>
                    <measurement group_id="O2" value="3.3" spread="4.41"/>
                    <measurement group_id="O3" value="-2.2" spread="6.13"/>
                    <measurement group_id="O4" value="5.6" spread="7.23"/>
                    <measurement group_id="O5" value="0.5" spread="7.47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.7" spread="7.74"/>
                    <measurement group_id="O2" value="13.8" spread="4.67"/>
                    <measurement group_id="O3" value="2.6" spread="6.31"/>
                    <measurement group_id="O4" value="6.9" spread="6.52"/>
                    <measurement group_id="O5" value="3.6" spread="9.71"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.8" spread="8.66"/>
                    <measurement group_id="O2" value="7.5" spread="5.39"/>
                    <measurement group_id="O3" value="0.8" spread="6.16"/>
                    <measurement group_id="O4" value="6.4" spread="3.46"/>
                    <measurement group_id="O5" value="4.7" spread="5.80"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.5" spread="7.29"/>
                    <measurement group_id="O2" value="6.8" spread="5.74"/>
                    <measurement group_id="O3" value="2.0" spread="8.62"/>
                    <measurement group_id="O4" value="3.0" spread="3.96"/>
                    <measurement group_id="O5" value="3.6" spread="7.44"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.3" spread="3.83"/>
                    <measurement group_id="O2" value="1.7" spread="3.83"/>
                    <measurement group_id="O3" value="1.2" spread="6.31"/>
                    <measurement group_id="O4" value="4.3" spread="5.05"/>
                    <measurement group_id="O5" value="3.6" spread="8.31"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.2" spread="6.88"/>
                    <measurement group_id="O2" value="7.8" spread="5.46"/>
                    <measurement group_id="O3" value="1.5" spread="7.08"/>
                    <measurement group_id="O4" value="8.5" spread="6.83"/>
                    <measurement group_id="O5" value="4.0" spread="7.92"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.0" spread="5.10"/>
                    <measurement group_id="O2" value="15.3" spread="6.53"/>
                    <measurement group_id="O3" value="5.5" spread="8.81"/>
                    <measurement group_id="O4" value="10.2" spread="5.56"/>
                    <measurement group_id="O5" value="8.8" spread="6.22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Creatinine, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.7" spread="8.91"/>
                    <measurement group_id="O2" value="4.5" spread="4.89"/>
                    <measurement group_id="O3" value="-0.3" spread="7.66"/>
                    <measurement group_id="O4" value="3.6" spread="3.55"/>
                    <measurement group_id="O5" value="1.7" spread="5.17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct Bilirubin, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.6" spread="0.55"/>
                    <measurement group_id="O2" value="0.0" spread="1.00"/>
                    <measurement group_id="O3" value="-0.4" spread="1.18"/>
                    <measurement group_id="O4" value="-1.5" spread="1.73"/>
                    <measurement group_id="O5" value="-0.5" spread="1.31"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct Bilirubin, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.8" spread="0.45"/>
                    <measurement group_id="O2" value="-0.3" spread="0.82"/>
                    <measurement group_id="O3" value="-0.4" spread="1.03"/>
                    <measurement group_id="O4" value="-0.2" spread="0.41"/>
                    <measurement group_id="O5" value="0.0" spread="0.95"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct Bilirubin, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.4" spread="0.55"/>
                    <measurement group_id="O2" value="-1.0" spread="0.82"/>
                    <measurement group_id="O3" value="-0.4" spread="1.20"/>
                    <measurement group_id="O4" value="-0.5" spread="1.22"/>
                    <measurement group_id="O5" value="-0.3" spread="1.36"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct Bilirubin, Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.4" spread="0.89"/>
                    <measurement group_id="O2" value="0.2" spread="1.10"/>
                    <measurement group_id="O3" value="-0.3" spread="1.19"/>
                    <measurement group_id="O4" value="-0.3" spread="1.03"/>
                    <measurement group_id="O5" value="-0.3" spread="1.37"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct Bilirubin, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.4" spread="0.89"/>
                    <measurement group_id="O2" value="0.0" spread="1.26"/>
                    <measurement group_id="O3" value="0.0" spread="1.13"/>
                    <measurement group_id="O4" value="-0.6" spread="1.52"/>
                    <measurement group_id="O5" value="-0.3" spread="1.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct Bilirubin, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.4" spread="0.55"/>
                    <measurement group_id="O2" value="-0.4" spread="1.14"/>
                    <measurement group_id="O3" value="-0.5" spread="0.99"/>
                    <measurement group_id="O4" value="-0.6" spread="1.52"/>
                    <measurement group_id="O5" value="-0.4" spread="1.24"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct Bilirubin, Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0" spread="0.82"/>
                    <measurement group_id="O2" value="0.0" spread="0.82"/>
                    <measurement group_id="O3" value="-0.4" spread="1.26"/>
                    <measurement group_id="O4" value="-2.5" spread="0.71"/>
                    <measurement group_id="O5" value="-0.4" spread="1.43"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct Bilirubin, Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.8" spread="0.45"/>
                    <measurement group_id="O2" value="-0.2" spread="0.98"/>
                    <measurement group_id="O3" value="-0.2" spread="1.14"/>
                    <measurement group_id="O4" value="-0.2" spread="1.30"/>
                    <measurement group_id="O5" value="-0.3" spread="1.30"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct Bilirubin, Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.4" spread="0.55"/>
                    <measurement group_id="O2" value="-0.2" spread="0.84"/>
                    <measurement group_id="O3" value="-0.2" spread="1.40"/>
                    <measurement group_id="O4" value="-0.6" spread="0.89"/>
                    <measurement group_id="O5" value="-0.3" spread="1.48"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Direct bilirubin, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.8" spread="0.84"/>
                    <measurement group_id="O2" value="0.3" spread="1.21"/>
                    <measurement group_id="O3" value="0.7" spread="2.17"/>
                    <measurement group_id="O4" value="0.4" spread="1.52"/>
                    <measurement group_id="O5" value="0.2" spread="1.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Chemistry Parameter: Protein</title>
        <description>Blood samples were collected to analyze the chemistry parameter: Protein. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Chemistry Parameter: Protein</title>
          <description>Blood samples were collected to analyze the chemistry parameter: Protein. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>Grams per liter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.5" spread="2.35"/>
                    <measurement group_id="O2" value="-1.0" spread="2.19"/>
                    <measurement group_id="O3" value="0.2" spread="3.34"/>
                    <measurement group_id="O4" value="1.7" spread="2.14"/>
                    <measurement group_id="O5" value="-0.9" spread="3.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread="3.02"/>
                    <measurement group_id="O2" value="0.0" spread="2.37"/>
                    <measurement group_id="O3" value="-0.3" spread="2.78"/>
                    <measurement group_id="O4" value="5.9" spread="3.53"/>
                    <measurement group_id="O5" value="-0.6" spread="2.82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="5.61"/>
                    <measurement group_id="O2" value="-1.3" spread="1.75"/>
                    <measurement group_id="O3" value="-0.1" spread="2.53"/>
                    <measurement group_id="O4" value="2.1" spread="2.48"/>
                    <measurement group_id="O5" value="0.0" spread="2.86"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8 predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.0" spread="3.03"/>
                    <measurement group_id="O2" value="-0.8" spread="2.48"/>
                    <measurement group_id="O3" value="-0.5" spread="2.69"/>
                    <measurement group_id="O4" value="1.4" spread="2.15"/>
                    <measurement group_id="O5" value="0.1" spread="2.56"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.5" spread="4.04"/>
                    <measurement group_id="O2" value="0.7" spread="1.97"/>
                    <measurement group_id="O3" value="-0.6" spread="3.12"/>
                    <measurement group_id="O4" value="1.7" spread="1.98"/>
                    <measurement group_id="O5" value="0.0" spread="4.08"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.7" spread="3.08"/>
                    <measurement group_id="O2" value="-1.0" spread="2.45"/>
                    <measurement group_id="O3" value="-0.3" spread="2.72"/>
                    <measurement group_id="O4" value="2.9" spread="2.12"/>
                    <measurement group_id="O5" value="-0.3" spread="3.36"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.5" spread="4.32"/>
                    <measurement group_id="O2" value="-3.5" spread="1.87"/>
                    <measurement group_id="O3" value="-2.0" spread="4.14"/>
                    <measurement group_id="O4" value="0.2" spread="1.94"/>
                    <measurement group_id="O5" value="-1.8" spread="3.85"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.2" spread="3.31"/>
                    <measurement group_id="O2" value="-1.7" spread="2.50"/>
                    <measurement group_id="O3" value="-1.8" spread="3.57"/>
                    <measurement group_id="O4" value="2.0" spread="2.00"/>
                    <measurement group_id="O5" value="-0.2" spread="3.79"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.0" spread="2.53"/>
                    <measurement group_id="O2" value="-0.8" spread="2.64"/>
                    <measurement group_id="O3" value="-1.1" spread="3.90"/>
                    <measurement group_id="O4" value="2.7" spread="2.42"/>
                    <measurement group_id="O5" value="0.6" spread="3.90"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.0" spread="2.28"/>
                    <measurement group_id="O2" value="-1.2" spread="1.94"/>
                    <measurement group_id="O3" value="-0.5" spread="3.43"/>
                    <measurement group_id="O4" value="0.4" spread="3.26"/>
                    <measurement group_id="O5" value="0.4" spread="4.05"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Number of Participants With Abnormal Urinalysis</title>
        <description>Urine samples were collected analyze the abnormal findings for potential of hydrogen (pH), glucose, protein, blood, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase by dipstick.</description>
        <time_frame>Up to Day 28</time_frame>
        <population>Safety Population</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Number of Participants With Abnormal Urinalysis</title>
          <description>Urine samples were collected analyze the abnormal findings for potential of hydrogen (pH), glucose, protein, blood, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase by dipstick.</description>
          <population>Safety Population</population>
          <units>Participants</units>
          <param>Count of Participants</param>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Vital Signs: SBP and DBP</title>
        <description>SBP and DBP were measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12,and 14 (pre dose and 72 hours) and Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Vital Signs: SBP and DBP</title>
          <description>SBP and DBP were measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Millimeters of mercury (mmHg)</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>SBP, Day 1, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.5" spread="4.76"/>
                    <measurement group_id="O2" value="1.2" spread="9.87"/>
                    <measurement group_id="O3" value="-0.5" spread="4.68"/>
                    <measurement group_id="O4" value="2.9" spread="5.76"/>
                    <measurement group_id="O5" value="-1.1" spread="8.48"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.5" spread="2.88"/>
                    <measurement group_id="O2" value="1.0" spread="10.30"/>
                    <measurement group_id="O3" value="0.6" spread="6.47"/>
                    <measurement group_id="O4" value="2.6" spread="3.40"/>
                    <measurement group_id="O5" value="-2.6" spread="7.84"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="5.79"/>
                    <measurement group_id="O2" value="-0.5" spread="9.20"/>
                    <measurement group_id="O3" value="-2.2" spread="6.33"/>
                    <measurement group_id="O4" value="3.0" spread="5.42"/>
                    <measurement group_id="O5" value="-3.3" spread="12.67"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.7" spread="5.09"/>
                    <measurement group_id="O2" value="1.2" spread="9.87"/>
                    <measurement group_id="O3" value="0.0" spread="5.72"/>
                    <measurement group_id="O4" value="3.0" spread="7.48"/>
                    <measurement group_id="O5" value="-1.2" spread="12.94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, Day 8, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.5" spread="3.73"/>
                    <measurement group_id="O2" value="3.3" spread="9.85"/>
                    <measurement group_id="O3" value="-1.4" spread="6.19"/>
                    <measurement group_id="O4" value="4.3" spread="5.65"/>
                    <measurement group_id="O5" value="-1.4" spread="11.80"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.8" spread="3.06"/>
                    <measurement group_id="O2" value="0.8" spread="9.37"/>
                    <measurement group_id="O3" value="-1.9" spread="6.66"/>
                    <measurement group_id="O4" value="3.7" spread="4.11"/>
                    <measurement group_id="O5" value="-5.2" spread="12.77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.8" spread="2.64"/>
                    <measurement group_id="O2" value="0.8" spread="10.15"/>
                    <measurement group_id="O3" value="-2.0" spread="5.70"/>
                    <measurement group_id="O4" value="3.3" spread="5.71"/>
                    <measurement group_id="O5" value="-4.6" spread="11.88"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, Day 14, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.8" spread="3.97"/>
                    <measurement group_id="O2" value="0.3" spread="14.00"/>
                    <measurement group_id="O3" value="-1.3" spread="7.31"/>
                    <measurement group_id="O4" value="3.8" spread="5.56"/>
                    <measurement group_id="O5" value="-4.1" spread="12.33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, Day 14, 72 hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.3" spread="3.33"/>
                    <measurement group_id="O2" value="0.2" spread="10.98"/>
                    <measurement group_id="O3" value="-2.3" spread="6.21"/>
                    <measurement group_id="O4" value="0.2" spread="6.85"/>
                    <measurement group_id="O5" value="-2.0" spread="11.07"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>SBP, follow up, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.0" spread="8.56"/>
                    <measurement group_id="O2" value="1.3" spread="1.75"/>
                    <measurement group_id="O3" value="0.8" spread="6.43"/>
                    <measurement group_id="O4" value="4.1" spread="7.60"/>
                    <measurement group_id="O5" value="1.2" spread="7.03"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, Day 1, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.7" spread="5.65"/>
                    <measurement group_id="O2" value="-0.4" spread="2.76"/>
                    <measurement group_id="O3" value="-0.9" spread="5.78"/>
                    <measurement group_id="O4" value="2.3" spread="5.41"/>
                    <measurement group_id="O5" value="-0.8" spread="5.73"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.0" spread="3.03"/>
                    <measurement group_id="O2" value="-0.3" spread="5.20"/>
                    <measurement group_id="O3" value="0.9" spread="6.93"/>
                    <measurement group_id="O4" value="2.2" spread="4.28"/>
                    <measurement group_id="O5" value="0.8" spread="4.76"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.7" spread="5.85"/>
                    <measurement group_id="O2" value="-0.3" spread="5.68"/>
                    <measurement group_id="O3" value="-1.6" spread="7.18"/>
                    <measurement group_id="O4" value="3.1" spread="3.80"/>
                    <measurement group_id="O5" value="-1.3" spread="4.94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-4.7" spread="7.17"/>
                    <measurement group_id="O2" value="2.0" spread="2.19"/>
                    <measurement group_id="O3" value="0.2" spread="5.21"/>
                    <measurement group_id="O4" value="1.9" spread="4.06"/>
                    <measurement group_id="O5" value="-1.6" spread="4.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, Day 8, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.5" spread="7.89"/>
                    <measurement group_id="O2" value="0.5" spread="3.73"/>
                    <measurement group_id="O3" value="-1.3" spread="6.52"/>
                    <measurement group_id="O4" value="0.1" spread="4.63"/>
                    <measurement group_id="O5" value="0.3" spread="4.70"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.2" spread="6.27"/>
                    <measurement group_id="O2" value="0.8" spread="4.71"/>
                    <measurement group_id="O3" value="-1.2" spread="5.79"/>
                    <measurement group_id="O4" value="3.3" spread="4.96"/>
                    <measurement group_id="O5" value="-2.1" spread="7.13"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, Day 12, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="1.86"/>
                    <measurement group_id="O2" value="0.5" spread="4.85"/>
                    <measurement group_id="O3" value="-1.9" spread="6.16"/>
                    <measurement group_id="O4" value="0.9" spread="5.01"/>
                    <measurement group_id="O5" value="-2.3" spread="7.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, Day 14, predose, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.2" spread="3.13"/>
                    <measurement group_id="O2" value="-0.8" spread="2.56"/>
                    <measurement group_id="O3" value="-1.0" spread="6.93"/>
                    <measurement group_id="O4" value="0.8" spread="3.76"/>
                    <measurement group_id="O5" value="-1.9" spread="7.07"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, Day 14, 72 hours n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="2.88"/>
                    <measurement group_id="O2" value="-1.7" spread="2.42"/>
                    <measurement group_id="O3" value="-2.0" spread="6.03"/>
                    <measurement group_id="O4" value="-1.2" spread="4.67"/>
                    <measurement group_id="O5" value="-1.6" spread="4.50"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>DBP, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-3.0" spread="8.56"/>
                    <measurement group_id="O2" value="1.3" spread="1.75"/>
                    <measurement group_id="O3" value="0.8" spread="6.43"/>
                    <measurement group_id="O4" value="7" spread="4.1"/>
                    <measurement group_id="O5" value="1.2" spread="7.03"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Vital Sign: Pulse Rate</title>
        <description>Pulse rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
        <time_frame>Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12, and 14 (pre dose and 72 hours) and Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Vital Sign: Pulse Rate</title>
          <description>Pulse rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Beats per minute</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 1, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="4.27"/>
                    <measurement group_id="O2" value="0.6" spread="1.86"/>
                    <measurement group_id="O3" value="1.6" spread="4.98"/>
                    <measurement group_id="O4" value="-3.4" spread="3.31"/>
                    <measurement group_id="O5" value="5.3" spread="5.61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.3" spread="4.18"/>
                    <measurement group_id="O2" value="0.5" spread="4.93"/>
                    <measurement group_id="O3" value="2.5" spread="7.22"/>
                    <measurement group_id="O4" value="2.1" spread="5.79"/>
                    <measurement group_id="O5" value="3.1" spread="5.66"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread="3.27"/>
                    <measurement group_id="O2" value="1.5" spread="5.96"/>
                    <measurement group_id="O3" value="0.2" spread="6.17"/>
                    <measurement group_id="O4" value="2.7" spread="7.63"/>
                    <measurement group_id="O5" value="4.1" spread="6.34"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.8" spread="3.60"/>
                    <measurement group_id="O2" value="2.5" spread="5.47"/>
                    <measurement group_id="O3" value="0.8" spread="6.55"/>
                    <measurement group_id="O4" value="3.4" spread="4.43"/>
                    <measurement group_id="O5" value="3.2" spread="7.16"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.5" spread="3.94"/>
                    <measurement group_id="O2" value="1.3" spread="4.89"/>
                    <measurement group_id="O3" value="1.4" spread="8.02"/>
                    <measurement group_id="O4" value="2.7" spread="6.70"/>
                    <measurement group_id="O5" value="2.1" spread="5.34"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.5" spread="3.94"/>
                    <measurement group_id="O2" value="3.3" spread="5.79"/>
                    <measurement group_id="O3" value="1.0" spread="7.21"/>
                    <measurement group_id="O4" value="0.4" spread="5.62"/>
                    <measurement group_id="O5" value="1.8" spread="6.93"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.5" spread="4.51"/>
                    <measurement group_id="O2" value="2.5" spread="7.87"/>
                    <measurement group_id="O3" value="-0.1" spread="8.02"/>
                    <measurement group_id="O4" value="3.1" spread="10.64"/>
                    <measurement group_id="O5" value="2.5" spread="8.12"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.5" spread="3.62"/>
                    <measurement group_id="O2" value="-0.2" spread="5.12"/>
                    <measurement group_id="O3" value="-0.2" spread="7.40"/>
                    <measurement group_id="O4" value="1.5" spread="3.83"/>
                    <measurement group_id="O5" value="0.3" spread="4.61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 72 hours, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.0" spread="7.62"/>
                    <measurement group_id="O2" value="1.8" spread="4.40"/>
                    <measurement group_id="O3" value="2.9" spread="6.91"/>
                    <measurement group_id="O4" value="4.2" spread="4.31"/>
                    <measurement group_id="O5" value="5.0" spread="6.82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.3" spread="6.62"/>
                    <measurement group_id="O2" value="-1.3" spread="10.63"/>
                    <measurement group_id="O3" value="0.8" spread="9.36"/>
                    <measurement group_id="O4" value="9.6" spread="7.96"/>
                    <measurement group_id="O5" value="6.3" spread="7.33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Vital Sign: Temperature</title>
        <description>Temperature was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12, and 14 (pre dose and 72 hours) and Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Vital Sign: Temperature</title>
          <description>Temperature was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Degree Celsius</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 1, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.38" spread="0.313"/>
                    <measurement group_id="O2" value="0.08" spread="0.222"/>
                    <measurement group_id="O3" value="0.11" spread="0.414"/>
                    <measurement group_id="O4" value="0.11" spread="0.308"/>
                    <measurement group_id="O5" value="0.09" spread="0.276"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.25" spread="0.281"/>
                    <measurement group_id="O2" value="0.18" spread="0.331"/>
                    <measurement group_id="O3" value="-0.04" spread="0.507"/>
                    <measurement group_id="O4" value="-0.11" spread="0.279"/>
                    <measurement group_id="O5" value="0.14" spread="0.367"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.44" spread="0.512"/>
                    <measurement group_id="O2" value="0.28" spread="0.271"/>
                    <measurement group_id="O3" value="0.04" spread="0.425"/>
                    <measurement group_id="O4" value="0.11" spread="0.204"/>
                    <measurement group_id="O5" value="0.14" spread="0.374"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.33" spread="0.489"/>
                    <measurement group_id="O2" value="0.25" spread="0.226"/>
                    <measurement group_id="O3" value="-0.04" spread="0.342"/>
                    <measurement group_id="O4" value="-0.11" spread="0.491"/>
                    <measurement group_id="O5" value="0.14" spread="0.405"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.05" spread="0.373"/>
                    <measurement group_id="O2" value="0.20" spread="0.322"/>
                    <measurement group_id="O3" value="0.05" spread="0.255"/>
                    <measurement group_id="O4" value="-0.09" spread="0.372"/>
                    <measurement group_id="O5" value="-0.02" spread="0.379"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.30" spread="0.498"/>
                    <measurement group_id="O2" value="0.10" spread="0.593"/>
                    <measurement group_id="O3" value="-0.01" spread="0.355"/>
                    <measurement group_id="O4" value="-0.10" spread="0.289"/>
                    <measurement group_id="O5" value="0.09" spread="0.455"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.23" spread="0.489"/>
                    <measurement group_id="O2" value="0.23" spread="0.314"/>
                    <measurement group_id="O3" value="-0.02" spread="0.415"/>
                    <measurement group_id="O4" value="0.03" spread="0.320"/>
                    <measurement group_id="O5" value="0.06" spread="0.393"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.30" spread="0.290"/>
                    <measurement group_id="O2" value="0.13" spread="0.258"/>
                    <measurement group_id="O3" value="0.05" spread="0.309"/>
                    <measurement group_id="O4" value="0.05" spread="0.266"/>
                    <measurement group_id="O5" value="-0.02" spread="0.395"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 72 hours, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.30" spread="0.310"/>
                    <measurement group_id="O2" value="0.15" spread="0.302"/>
                    <measurement group_id="O3" value="0.06" spread="0.330"/>
                    <measurement group_id="O4" value="0.22" spread="0.256"/>
                    <measurement group_id="O5" value="0.06" spread="0.363"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.42" spread="0.264"/>
                    <measurement group_id="O2" value="0.37" spread="0.441"/>
                    <measurement group_id="O3" value="0.04" spread="0.586"/>
                    <measurement group_id="O4" value="0.23" spread="0.364"/>
                    <measurement group_id="O5" value="0.21" spread="0.317"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Change From Baseline in Vital Sign: Respiratory Rate</title>
        <description>Respiratory rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
        <time_frame>Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12 and 14 (pre dose and 72 hours) and Follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Change From Baseline in Vital Sign: Respiratory Rate</title>
          <description>Respiratory rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Breaths per minute</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 1, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.0" spread="2.37"/>
                    <measurement group_id="O2" value="2.2" spread="3.49"/>
                    <measurement group_id="O3" value="0.2" spread="2.15"/>
                    <measurement group_id="O4" value="0.1" spread="2.27"/>
                    <measurement group_id="O5" value="0.8" spread="2.22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 2, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.5" spread="2.88"/>
                    <measurement group_id="O2" value="2.3" spread="1.21"/>
                    <measurement group_id="O3" value="0.4" spread="2.00"/>
                    <measurement group_id="O4" value="1.6" spread="1.72"/>
                    <measurement group_id="O5" value="0.5" spread="1.95"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.5" spread="2.17"/>
                    <measurement group_id="O2" value="2.2" spread="1.94"/>
                    <measurement group_id="O3" value="-0.2" spread="1.50"/>
                    <measurement group_id="O4" value="0.6" spread="2.44"/>
                    <measurement group_id="O5" value="0.2" spread="1.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.7" spread="2.25"/>
                    <measurement group_id="O2" value="0.2" spread="1.47"/>
                    <measurement group_id="O3" value="0.1" spread="1.73"/>
                    <measurement group_id="O4" value="0.0" spread="1.91"/>
                    <measurement group_id="O5" value="-0.4" spread="1.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.2" spread="3.06"/>
                    <measurement group_id="O2" value="1.7" spread="1.03"/>
                    <measurement group_id="O3" value="0.0" spread="2.37"/>
                    <measurement group_id="O4" value="0.6" spread="1.90"/>
                    <measurement group_id="O5" value="0.5" spread="1.91"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.3" spread="3.20"/>
                    <measurement group_id="O2" value="1.5" spread="2.35"/>
                    <measurement group_id="O3" value="0.9" spread="1.69"/>
                    <measurement group_id="O4" value="0.6" spread="0.98"/>
                    <measurement group_id="O5" value="0.5" spread="1.74"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12, predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.7" spread="2.25"/>
                    <measurement group_id="O2" value="2.3" spread="2.80"/>
                    <measurement group_id="O3" value="0.4" spread="1.96"/>
                    <measurement group_id="O4" value="-0.1" spread="1.35"/>
                    <measurement group_id="O5" value="0.4" spread="2.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, predose, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.8" spread="2.14"/>
                    <measurement group_id="O2" value="2.7" spread="1.51"/>
                    <measurement group_id="O3" value="0.6" spread="1.98"/>
                    <measurement group_id="O4" value="-0.2" spread="2.23"/>
                    <measurement group_id="O5" value="0.4" spread="2.24"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14, 72 hours, n=6,6,25,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.0" spread="1.41"/>
                    <measurement group_id="O2" value="2.7" spread="1.63"/>
                    <measurement group_id="O3" value="0.5" spread="1.56"/>
                    <measurement group_id="O4" value="-0.5" spread="1.97"/>
                    <measurement group_id="O5" value="-0.4" spread="1.98"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.5" spread="2.95"/>
                    <measurement group_id="O2" value="0.8" spread="1.72"/>
                    <measurement group_id="O3" value="1.1" spread="2.38"/>
                    <measurement group_id="O4" value="0.1" spread="0.69"/>
                    <measurement group_id="O5" value="0.6" spread="2.10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Part 2: Number of Participants With Abnormal ECG Findings</title>
        <description>12-lead ECG were obtained at given time points. Abnormal findings were categorized as clinically significant (CS) and not clinically significant (NCS).Results are presented treatment wise.</description>
        <time_frame>Day 1 (0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4.5, 5, 5.5, 6, 8, 12, 24 hours); Pre-dose on Days 3, 4, 6, 8, 10, 12; Day 14: Pre-dose, 1, 2, 4.5, 5, 6, 12, 24, 48, 72 and 96 hours post-dose and follow up (Day 28)</time_frame>
        <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
          <group group_id="O5">
            <title>Part 2: Repeated Dose Placebo</title>
            <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Number of Participants With Abnormal ECG Findings</title>
          <description>12-lead ECG were obtained at given time points. Abnormal findings were categorized as clinically significant (CS) and not clinically significant (NCS).Results are presented treatment wise.</description>
          <population>Safety Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles).</population>
          <units>Participants</units>
          <param>Count of Participants</param>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
                <count group_id="O5" value="14"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>CS, Day 1, 0.5 hours, n=4,0,0,0,2</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="2"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1,1 hour, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 1.5 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 1, 2hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 1, 2.5 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 3 hours n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 1, 3.5 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 4.5 hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 5hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1,5.5 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 1, 6hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 1, 8 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 12 hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 1, 24 hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 3, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 4, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 6, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 8, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 10, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 12, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, Predose, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, Day 14, 1hour, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, 2 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, 4.5hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, 5hours, n=0,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="0"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, 6 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, 12 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, 24 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, 72 hours, n=6,6,24, 6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS,Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CS, FU (Day 28), n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1,0.5 hours, n=4,0,0,0,2</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="2"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1,1 hour, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1, 1.5 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 1, 2hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="2"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 1, 2.5 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS Day 1, 3 hours n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 1, 3.5 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1, 4.5 hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="1"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1, 5hours n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1,5.5 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 1, 6hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="2"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 1, 8 hours, n=4,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="4"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 1, 12 hours, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 3, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="1"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 4, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="1"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 6, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="2"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 8, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 10, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 12, Predose, n=6,6,25,7,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="25"/>
                    <count group_id="O4" value="7"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 14, Predose, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 14, 1hour, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 14, 2 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 14, 4.5 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="0"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 14, 5hours, n=0,0,0,0,1</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="0"/>
                    <count group_id="O2" value="0"/>
                    <count group_id="O3" value="0"/>
                    <count group_id="O4" value="0"/>
                    <count group_id="O5" value="1"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, Day 14, 6 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 14, 12 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="2"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 14, 24hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 14, 48 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="3"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 14, 72 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS,Day 14, 96 hours, n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="0"/>
                    <measurement group_id="O3" value="1"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="2"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>NCS, FU (Day 28), n=6,6,24,6,14</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="6"/>
                    <count group_id="O2" value="6"/>
                    <count group_id="O3" value="24"/>
                    <count group_id="O4" value="6"/>
                    <count group_id="O5" value="14"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0"/>
                    <measurement group_id="O2" value="1"/>
                    <measurement group_id="O3" value="2"/>
                    <measurement group_id="O4" value="0"/>
                    <measurement group_id="O5" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: Area Under the Plasma Concentration Time Curve (AUC) From Zero to 24 Hour (AUC[0-24]) of GSK3640254</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12,24 hours post-dose</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Area Under the Plasma Concentration Time Curve (AUC) From Zero to 24 Hour (AUC[0-24]) of GSK3640254</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Hour*microgram per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>95% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="4"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.056" lower_limit="0.030" upper_limit="0.103"/>
                    <measurement group_id="O2" value="0.171" lower_limit="0.126" upper_limit="0.231"/>
                    <measurement group_id="O3" value="0.576" lower_limit="0.454" upper_limit="0.730"/>
                    <measurement group_id="O4" value="1.546" lower_limit="1.178" upper_limit="2.028"/>
                    <measurement group_id="O5" value="4.177" lower_limit="2.161" upper_limit="8.074"/>
                    <measurement group_id="O6" value="7.334" lower_limit="5.415" upper_limit="9.933"/>
                    <measurement group_id="O7" value="21.666" lower_limit="12.599" upper_limit="37.259"/>
                    <measurement group_id="O8" value="20.743" lower_limit="13.296" upper_limit="32.362"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: AUC From Zero to Time of Last Sample Taken (AUC[0-Tlast]) of GSK3640254</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: AUC From Zero to Time of Last Sample Taken (AUC[0-Tlast]) of GSK3640254</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
          <units>Hour*microgram per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>95% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.020" lower_limit="0.005" upper_limit="0.080"/>
                    <measurement group_id="O2" value="0.184" lower_limit="0.120" upper_limit="0.282"/>
                    <measurement group_id="O3" value="1.082" lower_limit="0.875" upper_limit="1.338"/>
                    <measurement group_id="O4" value="2.816" lower_limit="2.148" upper_limit="3.692"/>
                    <measurement group_id="O5" value="8.060" lower_limit="4.228" upper_limit="15.367"/>
                    <measurement group_id="O6" value="14.068" lower_limit="9.545" upper_limit="20.735"/>
                    <measurement group_id="O7" value="40.238" lower_limit="24.234" upper_limit="66.812"/>
                    <measurement group_id="O8" value="37.626" lower_limit="23.290" upper_limit="60.786"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: AUC From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC[0-inf]) of GSK3640254</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: AUC From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC[0-inf]) of GSK3640254</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Hour*microgram per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>95% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="3"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.057" lower_limit="0.022" upper_limit="0.145"/>
                    <measurement group_id="O2" value="0.329" lower_limit="0.232" upper_limit="0.467"/>
                    <measurement group_id="O3" value="1.227" lower_limit="1.008" upper_limit="1.493"/>
                    <measurement group_id="O4" value="2.992" lower_limit="2.281" upper_limit="3.924"/>
                    <measurement group_id="O5" value="8.539" lower_limit="4.511" upper_limit="16.165"/>
                    <measurement group_id="O6" value="14.952" lower_limit="9.880" upper_limit="22.629"/>
                    <measurement group_id="O7" value="42.989" lower_limit="26.047" upper_limit="70.953"/>
                    <measurement group_id="O8" value="39.692" lower_limit="24.094" upper_limit="65.389"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: Apparent Terminal Phase Half-life (T1/2) of GSK3640254</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Most of the concentrations were below limit of quantification (BLQ) at this dose group this value and/ or %AUC extrapolated was &gt;20% for all participants so this value should be used with caution. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Apparent Terminal Phase Half-life (T1/2) of GSK3640254</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Most of the concentrations were below limit of quantification (BLQ) at this dose group this value and/ or %AUC extrapolated was &gt;20% for all participants so this value should be used with caution. Results are presented treatment wise.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Hour</units>
          <param>Geometric Mean</param>
          <dispersion>95% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="3"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.886" lower_limit="3.427" upper_limit="18.145"/>
                    <measurement group_id="O2" value="20.486" lower_limit="16.450" upper_limit="25.514"/>
                    <measurement group_id="O3" value="25.332" lower_limit="20.741" upper_limit="30.938"/>
                    <measurement group_id="O4" value="21.221" lower_limit="17.557" upper_limit="25.650"/>
                    <measurement group_id="O5" value="22.838" lower_limit="20.268" upper_limit="25.734"/>
                    <measurement group_id="O6" value="22.620" lower_limit="18.069" upper_limit="28.316"/>
                    <measurement group_id="O7" value="23.737" lower_limit="19.747" upper_limit="28.533"/>
                    <measurement group_id="O8" value="20.761" lower_limit="16.171" upper_limit="26.654"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: Apparent Oral Clearance (CL/F) of GSK3640254</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Apparent Oral Clearance (CL/F) of GSK3640254</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1. Only those participants with data available at the specified data points were analyzed (represented by n= X in the category titles).</population>
          <units>Liters/hour</units>
          <param>Geometric Mean</param>
          <dispersion>95% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="3"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="17.685" lower_limit="6.889" upper_limit="45.399"/>
                    <measurement group_id="O2" value="9.119" lower_limit="6.428" upper_limit="12.937"/>
                    <measurement group_id="O3" value="8.152" lower_limit="6.697" upper_limit="9.922"/>
                    <measurement group_id="O4" value="10.027" lower_limit="7.645" upper_limit="13.150"/>
                    <measurement group_id="O5" value="11.711" lower_limit="6.186" upper_limit="22.168"/>
                    <measurement group_id="O6" value="13.376" lower_limit="8.838" upper_limit="20.244"/>
                    <measurement group_id="O7" value="9.305" lower_limit="5.638" upper_limit="15.357"/>
                    <measurement group_id="O8" value="17.636" lower_limit="10.705" upper_limit="29.053"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: Maximum Observed Concentration (Cmax), Concentration of GSK3640254 at 24 Hours (C24) and Last Quantifiable Concentration (Clast) of GSK3640254</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Maximum Observed Concentration (Cmax), Concentration of GSK3640254 at 24 Hours (C24) and Last Quantifiable Concentration (Clast) of GSK3640254</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
          <units>Micrograms per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>95% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Cmax</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.005" lower_limit="0.004" upper_limit="0.006"/>
                    <measurement group_id="O2" value="0.014" lower_limit="0.010" upper_limit="0.019"/>
                    <measurement group_id="O3" value="0.047" lower_limit="0.034" upper_limit="0.064"/>
                    <measurement group_id="O4" value="0.130" lower_limit="0.104" upper_limit="0.162"/>
                    <measurement group_id="O5" value="0.372" lower_limit="0.190" upper_limit="0.730"/>
                    <measurement group_id="O6" value="0.579" lower_limit="0.438" upper_limit="0.765"/>
                    <measurement group_id="O7" value="1.881" lower_limit="1.150" upper_limit="3.077"/>
                    <measurement group_id="O8" value="1.724" lower_limit="1.137" upper_limit="2.614"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>C24</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.001" lower_limit="0.000" upper_limit="0.005"/>
                    <measurement group_id="O2" value="0.005" lower_limit="0.004" upper_limit="0.007"/>
                    <measurement group_id="O3" value="0.017" lower_limit="0.013" upper_limit="0.023"/>
                    <measurement group_id="O4" value="0.043" lower_limit="0.031" upper_limit="0.062"/>
                    <measurement group_id="O5" value="0.126" lower_limit="0.061" upper_limit="0.261"/>
                    <measurement group_id="O6" value="0.245" lower_limit="0.153" upper_limit="0.392"/>
                    <measurement group_id="O7" value="0.610" lower_limit="0.356" upper_limit="1.046"/>
                    <measurement group_id="O8" value="0.579" lower_limit="0.348" upper_limit="0.963"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Clast</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.004" lower_limit="0.003" upper_limit="0.005"/>
                    <measurement group_id="O2" value="0.005" lower_limit="0.004" upper_limit="0.006"/>
                    <measurement group_id="O3" value="0.004" lower_limit="0.003" upper_limit="0.005"/>
                    <measurement group_id="O4" value="0.005" lower_limit="0.004" upper_limit="0.008"/>
                    <measurement group_id="O5" value="0.014" lower_limit="0.008" upper_limit="0.026"/>
                    <measurement group_id="O6" value="0.024" lower_limit="0.010" upper_limit="0.054"/>
                    <measurement group_id="O7" value="0.072" lower_limit="0.043" upper_limit="0.120"/>
                    <measurement group_id="O8" value="0.054" lower_limit="0.022" upper_limit="0.128"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: Time of Occurrence of Cmax (Tmax), Lag Time (Tlag), and Time to Reach Clast (Tlast) of GSK3640254</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Time of Occurrence of Cmax (Tmax), Lag Time (Tlag), and Time to Reach Clast (Tlast) of GSK3640254</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
          <units>Hour</units>
          <param>Median</param>
          <dispersion>Full Range</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Tmax</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.500" lower_limit="2.500" upper_limit="6.000"/>
                    <measurement group_id="O2" value="4.500" lower_limit="2.000" upper_limit="5.000"/>
                    <measurement group_id="O3" value="3.500" lower_limit="2.500" upper_limit="5.000"/>
                    <measurement group_id="O4" value="4.000" lower_limit="2.500" upper_limit="5.000"/>
                    <measurement group_id="O5" value="3.750" lower_limit="2.000" upper_limit="5.000"/>
                    <measurement group_id="O6" value="3.000" lower_limit="1.983" upper_limit="4.000"/>
                    <measurement group_id="O7" value="3.250" lower_limit="2.000" upper_limit="6.000"/>
                    <measurement group_id="O8" value="3.250" lower_limit="2.000" upper_limit="4.500"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Tlag</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.000" lower_limit="1.500" upper_limit="4.500"/>
                    <measurement group_id="O2" value="1.250" lower_limit="0.500" upper_limit="3.000"/>
                    <measurement group_id="O3" value="0.750" lower_limit="0.500" upper_limit="2.000"/>
                    <measurement group_id="O4" value="0.500" lower_limit="0.500" upper_limit="0.517"/>
                    <measurement group_id="O5" value="0.750" lower_limit="0.000" upper_limit="1.000"/>
                    <measurement group_id="O6" value="0.500" lower_limit="0.500" upper_limit="0.500"/>
                    <measurement group_id="O7" value="0.500" lower_limit="0.000" upper_limit="0.500"/>
                    <measurement group_id="O8" value="0.500" lower_limit="0.000" upper_limit="0.517"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Tlast</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.017" lower_limit="4.500" upper_limit="48.000"/>
                    <measurement group_id="O2" value="24.017" lower_limit="24.000" upper_limit="48.017"/>
                    <measurement group_id="O3" value="72.008" lower_limit="72.000" upper_limit="96.083"/>
                    <measurement group_id="O4" value="96.000" lower_limit="72.033" upper_limit="96.000"/>
                    <measurement group_id="O5" value="96.000" lower_limit="95.317" upper_limit="96.017"/>
                    <measurement group_id="O6" value="95.667" lower_limit="95.667" upper_limit="96.000"/>
                    <measurement group_id="O7" value="95.667" lower_limit="95.483" upper_limit="96.100"/>
                    <measurement group_id="O8" value="95.542" lower_limit="95.250" upper_limit="96.000"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: AUC(0-24) of GSK3640254: Day 1</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12 and 24 hours post-dose on Day 1</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: AUC(0-24) of GSK3640254: Day 1</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
          <units>Hour*micrograms per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.855" spread="29.621"/>
                    <measurement group_id="O2" value="6.801" spread="22.970"/>
                    <measurement group_id="O3" value="8.257" spread="49.782"/>
                    <measurement group_id="O4" value="13.456" spread="23.743"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Cmax, C24 of GSK3640254 on Day 1</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12 hours post-dose on Day 1</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Cmax, C24 of GSK3640254 on Day 1</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
          <units>Micrograms per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Cmax</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.215" spread="24.412"/>
                    <measurement group_id="O2" value="0.536" spread="22.959"/>
                    <measurement group_id="O3" value="0.614" spread="44.354"/>
                    <measurement group_id="O4" value="1.044" spread="29.225"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>C24</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.082" spread="33.583"/>
                    <measurement group_id="O2" value="0.207" spread="22.856"/>
                    <measurement group_id="O3" value="0.238" spread="58.452"/>
                    <measurement group_id="O4" value="0.417" spread="39.681"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Tmax, Tlag of GSK3640254 on Day 1</title>
        <description>Blood samples were collected at indicated timepoints and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.</description>
        <time_frame>Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12 hours post-dose on Day 1</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Tmax, Tlag of GSK3640254 on Day 1</title>
          <description>Blood samples were collected at indicated timepoints and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
          <units>Hour</units>
          <param>Median</param>
          <dispersion>Full Range</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Tmax</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.750" lower_limit="3.000" upper_limit="5.017"/>
                    <measurement group_id="O2" value="4.250" lower_limit="2.000" upper_limit="5.000"/>
                    <measurement group_id="O3" value="4.000" lower_limit="1.500" upper_limit="5.633"/>
                    <measurement group_id="O4" value="4.000" lower_limit="2.500" upper_limit="6.000"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Tlag</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.508" lower_limit="0.500" upper_limit="0.550"/>
                    <measurement group_id="O2" value="0.500" lower_limit="0.500" upper_limit="0.500"/>
                    <measurement group_id="O3" value="0.500" lower_limit="0.000" upper_limit="1.500"/>
                    <measurement group_id="O4" value="0.500" lower_limit="0.000" upper_limit="1.000"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Tmax GSK3640254 on Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Tmax GSK3640254 on Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Hour</units>
          <param>Median</param>
          <dispersion>Full Range</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="24"/>
                <count group_id="O4" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.775" lower_limit="2.500" upper_limit="5.000"/>
                    <measurement group_id="O2" value="4.000" lower_limit="1.500" upper_limit="4.500"/>
                    <measurement group_id="O3" value="3.750" lower_limit="1.500" upper_limit="5.500"/>
                    <measurement group_id="O4" value="4.250" lower_limit="1.500" upper_limit="6.000"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Cmax of GSK3640254 on Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Cmax of GSK3640254 on Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Micrograms per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="24"/>
                <count group_id="O4" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.414" spread="31.556"/>
                    <measurement group_id="O2" value="1.182" spread="10.264"/>
                    <measurement group_id="O3" value="1.402" spread="30.839"/>
                    <measurement group_id="O4" value="2.156" spread="20.360"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: AUC From Pre-dose to the End of the Dosing Interval at Steady State (AUC[0-tau]): Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: AUC From Pre-dose to the End of the Dosing Interval at Steady State (AUC[0-tau]): Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>hour* micrograms per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="24"/>
                <count group_id="O4" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.282" spread="34.010"/>
                    <measurement group_id="O2" value="17.506" spread="13.794"/>
                    <measurement group_id="O3" value="21.501" spread="34.205"/>
                    <measurement group_id="O4" value="31.954" spread="35.380"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Plasma Trough Concentration (Ctau) of GSK3640254: Day 14</title>
        <description>Blood samples were collected at indicated timepoints and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The PK parameter name for Part 2 (Day 14) trough concentration was changed using Phoenix WinNonlin 8 from Ct to Ctrough. Day 15 Ctrough values were used for dose proportionality and time to steady-state assessments.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Plasma Trough Concentration (Ctau) of GSK3640254: Day 14</title>
          <description>Blood samples were collected at indicated timepoints and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The PK parameter name for Part 2 (Day 14) trough concentration was changed using Phoenix WinNonlin 8 from Ct to Ctrough. Day 15 Ctrough values were used for dose proportionality and time to steady-state assessments.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
          <units>micrograms per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="24"/>
                <count group_id="O4" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.186" spread="35.128"/>
                    <measurement group_id="O2" value="0.558" spread="21.407"/>
                    <measurement group_id="O3" value="0.630" spread="37.814"/>
                    <measurement group_id="O4" value="0.980" spread="41.815"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: T1/2 of GSK3640254: Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: T1/2 of GSK3640254: Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Hour</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="24"/>
                <count group_id="O4" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="24.847" spread="5.087"/>
                    <measurement group_id="O2" value="28.358" spread="19.199"/>
                    <measurement group_id="O3" value="22.125" spread="14.515"/>
                    <measurement group_id="O4" value="22.350" spread="12.641"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: CL/F of GSK3640254: Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: CL/F of GSK3640254: Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Liter per hour</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="24"/>
                <count group_id="O4" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.959" spread="34.010"/>
                    <measurement group_id="O2" value="5.712" spread="13.794"/>
                    <measurement group_id="O3" value="9.302" spread="34.205"/>
                    <measurement group_id="O4" value="10.014" spread="35.380"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: Dose Proportionality (AUC[0-inf]) Following Single Dose of GSK3640254 on Day 1</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Dose Proportionality (AUC[0-inf]) Following Single Dose of GSK3640254 on Day 1</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
          <units>hour*micrograms per mililiter</units>
          <param>Geometric Mean</param>
          <dispersion>95% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.057" lower_limit="0.022" upper_limit="0.145"/>
                    <measurement group_id="O2" value="0.329" lower_limit="0.232" upper_limit="0.467"/>
                    <measurement group_id="O3" value="1.1227" lower_limit="1.008" upper_limit="1.493"/>
                    <measurement group_id="O4" value="2.992" lower_limit="2.281" upper_limit="3.924"/>
                    <measurement group_id="O5" value="8.539" lower_limit="4.511" upper_limit="16.165"/>
                    <measurement group_id="O6" value="14.952" lower_limit="9.880" upper_limit="22.629"/>
                    <measurement group_id="O7" value="42.989" lower_limit="26.047" upper_limit="70.953"/>
                    <measurement group_id="O8" value="39.692" lower_limit="24.094" upper_limit="65.389"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
              <group_id>O3</group_id>
              <group_id>O4</group_id>
              <group_id>O5</group_id>
              <group_id>O6</group_id>
              <group_id>O7</group_id>
              <group_id>O8</group_id>
            </group_id_list>
            <non_inferiority_type>Other</non_inferiority_type>
            <param_type>Power model</param_type>
            <param_value>0.9476</param_value>
            <ci_percent>90</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>0.8982</ci_lower_limit>
            <ci_upper_limit>0.9971</ci_upper_limit>
            <estimate_desc>The statistical model (power model) is based on the PK parameters (AUC0-inf) from all active doses in Part 1</estimate_desc>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: Dose Proportionality (AUC0-24) Following Single Dose of GSK3640254 on Day 1</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24 hours post dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Dose Proportionality (AUC0-24) Following Single Dose of GSK3640254 on Day 1</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
          <units>hour*micrograms per mililiter</units>
          <param>Geometric Mean</param>
          <dispersion>95% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.056" lower_limit="0.030" upper_limit="0.103"/>
                    <measurement group_id="O2" value="0.171" lower_limit="0.126" upper_limit="0.231"/>
                    <measurement group_id="O3" value="0.576" lower_limit="0.454" upper_limit="0.730"/>
                    <measurement group_id="O4" value="1.546" lower_limit="1.178" upper_limit="2.028"/>
                    <measurement group_id="O5" value="4.177" lower_limit="2.161" upper_limit="8.074"/>
                    <measurement group_id="O6" value="7.334" lower_limit="5.415" upper_limit="9.933"/>
                    <measurement group_id="O7" value="21.666" lower_limit="12.599" upper_limit="37.259"/>
                    <measurement group_id="O8" value="20.743" lower_limit="13.296" upper_limit="32.362"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
              <group_id>O3</group_id>
              <group_id>O4</group_id>
              <group_id>O5</group_id>
              <group_id>O6</group_id>
              <group_id>O7</group_id>
              <group_id>O8</group_id>
            </group_id_list>
            <non_inferiority_type>Other</non_inferiority_type>
            <param_type>Power model</param_type>
            <param_value>0.9280</param_value>
            <ci_percent>90</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>0.8877</ci_lower_limit>
            <ci_upper_limit>0.9683</ci_upper_limit>
            <estimate_desc>The statistical model (power model) is based on the PK parameters (AUC0-24) from all active doses in Part 1</estimate_desc>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 1: Dose Proportionality for Cmax Following Single Dose of GSK3640254 on Day 1</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 1: GSK3640254 1 mg</title>
            <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O2">
            <title>Part 1: GSK3640254 3 mg</title>
            <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O3">
            <title>Part 1: GSK3640254 10 mg</title>
            <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O4">
            <title>Part 1: GSK3640254 30mg</title>
            <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O5">
            <title>Part 1: GSK3640254 100 mg</title>
            <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O6">
            <title>Part 1: GSK3640254 200 mg</title>
            <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O7">
            <title>Part 1: GSK3640254 400 mg</title>
            <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
          </group>
          <group group_id="O8">
            <title>Part 1: GSK3640254 700 mg</title>
            <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
          </group>
        </group_list>
        <measure>
          <title>Part 1: Dose Proportionality for Cmax Following Single Dose of GSK3640254 on Day 1</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the single dose phase of the study Part 1.</population>
          <units>Micrograms per mililiter</units>
          <param>Geometric Mean</param>
          <dispersion>95% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="6"/>
                <count group_id="O4" value="6"/>
                <count group_id="O5" value="6"/>
                <count group_id="O6" value="6"/>
                <count group_id="O7" value="6"/>
                <count group_id="O8" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.005" lower_limit="0.004" upper_limit="0.006"/>
                    <measurement group_id="O2" value="0.014" lower_limit="0.010" upper_limit="0.019"/>
                    <measurement group_id="O3" value="0.047" lower_limit="0.034" upper_limit="0.064"/>
                    <measurement group_id="O4" value="0.130" lower_limit="0.104" upper_limit="0.162"/>
                    <measurement group_id="O5" value="0.372" lower_limit="0.190" upper_limit="0.730"/>
                    <measurement group_id="O6" value="0.579" lower_limit="0.438" upper_limit="0.765"/>
                    <measurement group_id="O7" value="1.881" lower_limit="1.150" upper_limit="3.077"/>
                    <measurement group_id="O8" value="1.724" lower_limit="1.137" upper_limit="2.614"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
              <group_id>O3</group_id>
              <group_id>O4</group_id>
              <group_id>O5</group_id>
              <group_id>O6</group_id>
              <group_id>O7</group_id>
              <group_id>O8</group_id>
            </group_id_list>
            <non_inferiority_type>Other</non_inferiority_type>
            <param_type>Power Model</param_type>
            <param_value>0.9352</param_value>
            <ci_percent>90</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>0.8970</ci_lower_limit>
            <ci_upper_limit>0.9734</ci_upper_limit>
            <estimate_desc>The statistical model (power model) is based on the PK parameters (Cmax) from all active doses in Part 1</estimate_desc>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Dose Proportionality (AUC0-tau) Following Repeated Dose of GSK3640254 on Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Dose Proportionality (AUC0-tau) Following Repeated Dose of GSK3640254 on Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>hour*microgram per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="24"/>
                <count group_id="O4" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.282" spread="34.010"/>
                    <measurement group_id="O2" value="17.506" spread="13.794"/>
                    <measurement group_id="O3" value="21.501" spread="34.205"/>
                    <measurement group_id="O4" value="31.954" spread="35.380"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
              <group_id>O3</group_id>
              <group_id>O4</group_id>
            </group_id_list>
            <non_inferiority_type>Other</non_inferiority_type>
            <param_type>Power model</param_type>
            <param_value>0.7968</param_value>
            <ci_percent>90</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>0.6424</ci_lower_limit>
            <ci_upper_limit>0.9512</ci_upper_limit>
            <estimate_desc>The statistical model (power model) is based on the PK parameters (AUC0-tau) from all active doses in Part 1</estimate_desc>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Dose Proportionality (Ctrough) Following Repeated Dose of GSK3640254 on Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Dose Proportionality (Ctrough) Following Repeated Dose of GSK3640254 on Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Micrograms per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="24"/>
                <count group_id="O4" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.205" spread="33.414"/>
                    <measurement group_id="O2" value="0.593" spread="16.359"/>
                    <measurement group_id="O3" value="0.615" spread="74.191"/>
                    <measurement group_id="O4" value="1.255" spread="37.220"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
              <group_id>O3</group_id>
              <group_id>O4</group_id>
            </group_id_list>
            <non_inferiority_type>Other</non_inferiority_type>
            <param_type>Power model</param_type>
            <param_value>0.7890</param_value>
            <ci_percent>90</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>0.6149</ci_lower_limit>
            <ci_upper_limit>0.9631</ci_upper_limit>
            <estimate_desc>The statistical model (power model) is based on the PK parameters (Ctrough) from all active doses in Part 2</estimate_desc>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Dose Proportionality (Cmax) Following Repeated Dose of GSK3640254 on Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Dose Proportionality (Cmax) Following Repeated Dose of GSK3640254 on Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Microgram per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="24"/>
                <count group_id="O4" value="6"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.414" spread="31.556"/>
                    <measurement group_id="O2" value="1.182" spread="10.264"/>
                    <measurement group_id="O3" value="1.402" spread="30.839"/>
                    <measurement group_id="O4" value="2.156" spread="20.360"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
              <group_id>O3</group_id>
              <group_id>O4</group_id>
            </group_id_list>
            <non_inferiority_type>Other</non_inferiority_type>
            <param_type>Power model</param_type>
            <param_value>0.7955</param_value>
            <ci_percent>90</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>0.6562</ci_lower_limit>
            <ci_upper_limit>0.9349</ci_upper_limit>
            <estimate_desc>The statistical model (power model) is based on the PK parameters (Cmax) from all active doses in Part 2</estimate_desc>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Accumulation Ratio of AUC(0-tau) (R [AUC{0-TAU}]) From Day 1 to Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 14 and Day 1, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Accumulation Ratio of AUC(0-tau) (R [AUC{0-TAU}]) From Day 1 to Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 14 and Day 1, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
          <units>Ratio of AUC(0-tau)</units>
          <param>Number</param>
          <dispersion>90% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.2005" lower_limit="1.9116" upper_limit="2.5330"/>
                    <measurement group_id="O2" value="2.5739" lower_limit="2.2067" upper_limit="3.0022"/>
                    <measurement group_id="O3" value="2.6167" lower_limit="2.3460" upper_limit="2.9185"/>
                    <measurement group_id="O4" value="2.3634" lower_limit="1.7579" upper_limit="3.1774"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Accumulation Ratio of Cmax (R [CMAX]) From Day 1 to Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 14 and Day 1, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Accumulation Ratio of Cmax (R [CMAX]) From Day 1 to Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 14 and Day 1, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
          <units>Ratio of Cmax</units>
          <param>Number</param>
          <dispersion>90% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9276" lower_limit="1.6283" upper_limit="2.2818"/>
                    <measurement group_id="O2" value="2.2069" lower_limit="1.8360" upper_limit="2.6528"/>
                    <measurement group_id="O3" value="2.2994" lower_limit="2.0872" upper_limit="2.5331"/>
                    <measurement group_id="O4" value="2.0650" lower_limit="1.6064" upper_limit="2.6545"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Accumulation Ratio of C(Tau) (R[CTAU]) From Day 2 to Day 15</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 15 and Day 2, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 15 dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Accumulation Ratio of C(Tau) (R[CTAU]) From Day 2 to Day 15</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 15 and Day 2, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
          <units>Ratio of Ctau</units>
          <param>Number</param>
          <dispersion>90% Confidence Interval</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.1408" lower_limit="1.9402" upper_limit="2.3621"/>
                    <measurement group_id="O2" value="2.5847" lower_limit="2.1437" upper_limit="3.1165"/>
                    <measurement group_id="O3" value="2.5335" lower_limit="2.2133" upper_limit="2.9001"/>
                    <measurement group_id="O4" value="2.1666" lower_limit="1.4908" upper_limit="3.1488"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Pre-dose Concentration of GSK3640254 on Day 2 to Day 14</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. results are presented treatment wise.</description>
        <time_frame>Pre-dose on Days 2,3,4,6,8,10,12 and 14</time_frame>
        <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Pre-dose Concentration of GSK3640254 on Day 2 to Day 14</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. results are presented treatment wise.</description>
          <population>PK Population. The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2.</population>
          <units>Nanogram per milliliter</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 2 Predose</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="90.20" spread="25.312"/>
                    <measurement group_id="O2" value="221.55" spread="55.722"/>
                    <measurement group_id="O3" value="283.37" spread="137.243"/>
                    <measurement group_id="O4" value="476.58" spread="197.909"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 3 Predose</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="155.93" spread="41.869"/>
                    <measurement group_id="O2" value="449.82" spread="68.287"/>
                    <measurement group_id="O3" value="517.96" spread="239.825"/>
                    <measurement group_id="O4" value="753.02" spread="174.186"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 4 Predose</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="196.25" spread="55.807"/>
                    <measurement group_id="O2" value="524.87" spread="120.723"/>
                    <measurement group_id="O3" value="667.45" spread="295.479"/>
                    <measurement group_id="O4" value="926.40" spread="235.884"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 6 Predose</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="214.64" spread="75.891"/>
                    <measurement group_id="O2" value="550.48" spread="125.873"/>
                    <measurement group_id="O3" value="701.98" spread="349.091"/>
                    <measurement group_id="O4" value="969.06" spread="225.600"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8 Predose</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="230.50" spread="77.819"/>
                    <measurement group_id="O2" value="595.26" spread="151.167"/>
                    <measurement group_id="O3" value="712.79" spread="342.941"/>
                    <measurement group_id="O4" value="936.45" spread="278.866"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 10 Predose</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="218.97" spread="74.858"/>
                    <measurement group_id="O2" value="604.52" spread="137.121"/>
                    <measurement group_id="O3" value="802.81" spread="272.000"/>
                    <measurement group_id="O4" value="1051.91" spread="375.261"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 12 predose</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="221.10" spread="75.744"/>
                    <measurement group_id="O2" value="628.86" spread="114.448"/>
                    <measurement group_id="O3" value="726.13" spread="300.263"/>
                    <measurement group_id="O4" value="1182.80" spread="354.948"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 14 predose</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="214.16" spread="66.980"/>
                    <measurement group_id="O2" value="599.45" spread="97.262"/>
                    <measurement group_id="O3" value="706.76" spread="299.450"/>
                    <measurement group_id="O4" value="1324.29" spread="470.703"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Dose Proportionality (Cmax) Following Repeated Dose of GSK3640254 at Day 1</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Dose Proportionality (Cmax) Following Repeated Dose of GSK3640254 at Day 1</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>Microgram per milliliter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.215" spread="24.412"/>
                    <measurement group_id="O2" value="0.536" spread="22.959"/>
                    <measurement group_id="O3" value="0.614" spread="44.354"/>
                    <measurement group_id="O4" value="1.044" spread="29.225"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
              <group_id>O3</group_id>
              <group_id>O4</group_id>
            </group_id_list>
            <non_inferiority_type>Other</non_inferiority_type>
            <param_type>Power model</param_type>
            <param_value>0.7370</param_value>
            <ci_percent>90</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>0.5649</ci_lower_limit>
            <ci_upper_limit>0.9091</ci_upper_limit>
            <estimate_desc>The statistical model (power model) is based on the PK parameters (Cmax) from all active doses in Part 2</estimate_desc>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Part 2: Dose Proportionality (AUC0-24) Following Repeated Dose of GSK3640254 at Day 1</title>
        <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
        <time_frame>Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose</time_frame>
        <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
        <group_list>
          <group group_id="O1">
            <title>Part 2: GSK3640254 50 mg</title>
            <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
          </group>
          <group group_id="O2">
            <title>Part 2: GSK3640254 100 mg</title>
            <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
          </group>
          <group group_id="O3">
            <title>Part 2: GSK3640254 200 mg + Expansion</title>
            <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
          </group>
          <group group_id="O4">
            <title>Part 2: GSK3640254 320 mg</title>
            <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
          </group>
        </group_list>
        <measure>
          <title>Part 2: Dose Proportionality (AUC0-24) Following Repeated Dose of GSK3640254 at Day 1</title>
          <description>Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.</description>
          <population>PK Population, The PK Population include all participants who undergo plasma PK sampling and have evaluable PK parameters estimated during the repeat dose phase of the study Part 2. Only those participants with data available at the specified data points were analyzed.</population>
          <units>hour*micrograms per mililiter</units>
          <param>Geometric Mean</param>
          <dispersion>Geometric Coefficient of Variation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="6"/>
                <count group_id="O2" value="6"/>
                <count group_id="O3" value="25"/>
                <count group_id="O4" value="7"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.855" spread="29.621"/>
                    <measurement group_id="O2" value="6.801" spread="22.970"/>
                    <measurement group_id="O3" value="8.257" spread="49.782"/>
                    <measurement group_id="O4" value="13.456" spread="23.743"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
              <group_id>O3</group_id>
              <group_id>O4</group_id>
            </group_id_list>
            <non_inferiority_type>Other</non_inferiority_type>
            <param_type>Power model</param_type>
            <param_value>0.7397</param_value>
            <ci_percent>90</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>0.5576</ci_lower_limit>
            <ci_upper_limit>0.9218</ci_upper_limit>
            <estimate_desc>The statistical model (power model) is based on the PK parameters (AUC0-24) from all active doses in Part 2</estimate_desc>
          </analysis>
        </analysis_list>
      </outcome>
    </outcome_list>

    <reported_events>
      <time_frame>On-treatment and post-treatment non-serious adverse events and serious adverse events were collected up to Day 15 for Part 1 and Day 28 for Part 2 of the study.</time_frame>
      <desc>Safety Population was used to collect the adverse events</desc>
      <group_list>
        <group group_id="E1">
          <title>Part 1:GSK3640254 1 mg</title>
          <description>Participants received single dose of GSK3640254 1 mg following a moderate fat meal on Day 1</description>
        </group>
        <group group_id="E2">
          <title>Part 1:GSK3640254 3 mg</title>
          <description>Participants received single dose of GSK3640254 3 mg following a moderate fat meal on Day 1</description>
        </group>
        <group group_id="E3">
          <title>Part 1:GSK3640254 10 mg</title>
          <description>Participants received single dose of GSK3640254 10 mg following a moderate fat meal on Day 1</description>
        </group>
        <group group_id="E4">
          <title>Part 1:GSK3640254 30 mg</title>
          <description>Participants received single dose of GSK3640254 30 mg following a moderate fat meal on Day 1</description>
        </group>
        <group group_id="E5">
          <title>Part 1:GSK3640254 100 mg</title>
          <description>Participants received single dose of GSK3640254 100 mg following a moderate fat meal on Day 1</description>
        </group>
        <group group_id="E6">
          <title>Part 1:GSK3640254 200 mg</title>
          <description>Participants received single dose of GSK3640254 200 mg following a moderate fat meal on Day 1</description>
        </group>
        <group group_id="E7">
          <title>Part 1:GSK3640254 400 mg</title>
          <description>Participants received single dose of GSK3640254 400 mg following a moderate fat meal on Day 1</description>
        </group>
        <group group_id="E8">
          <title>Part 1:GSK3640254 700 mg</title>
          <description>Participants received single dose of GSK3640254 700 mg following a moderate fat meal on Day 1</description>
        </group>
        <group group_id="E9">
          <title>Part 1: Single Dose Placebo</title>
          <description>Participants received single dose of matching placebo following a moderate fat meal on Day 1</description>
        </group>
        <group group_id="E10">
          <title>Part 2: Repeated Dose GSK3640254 50 mg</title>
          <description>Participants received repeated dose of GSK3640254 50 mg once daily up to 14 days</description>
        </group>
        <group group_id="E11">
          <title>Part 2: Repeated Dose GSK3640254 100 mg</title>
          <description>Participants received repeated dose of GSK3640254 100 mg once daily up to 14 days</description>
        </group>
        <group group_id="E12">
          <title>Part 2: Repeated Dose GSK3640254 200mg +Expansion</title>
          <description>Participants received repeated dose of GSK3640254 200 mg once daily up to 14 days</description>
        </group>
        <group group_id="E13">
          <title>Part 2: Repeated Dose GSK3640254 320 mg</title>
          <description>Participants received repeated dose of GSK3640254 320 mg once daily up to 14 days</description>
        </group>
        <group group_id="E14">
          <title>Part 2: Repeated Dose Placebo</title>
          <description>Participants received repeated dose of matching placebo once daily up to 14 days</description>
        </group>
      </group_list>
      <serious_events>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, all-cause mortality</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Total, serious adverse events</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" subjects_affected="0" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </serious_events>
      <other_events>
        <frequency_threshold>5</frequency_threshold>
        <default_vocab>MedDRA Version 21.1</default_vocab>
        <default_assessment>Systematic Assessment</default_assessment>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, other adverse events</sub_title>
                <counts group_id="E1" subjects_affected="3" subjects_at_risk="6"/>
                <counts group_id="E2" subjects_affected="2" subjects_at_risk="6"/>
                <counts group_id="E3" subjects_affected="4" subjects_at_risk="6"/>
                <counts group_id="E4" subjects_affected="3" subjects_at_risk="6"/>
                <counts group_id="E5" subjects_affected="3" subjects_at_risk="6"/>
                <counts group_id="E6" subjects_affected="4" subjects_at_risk="6"/>
                <counts group_id="E7" subjects_affected="4" subjects_at_risk="6"/>
                <counts group_id="E8" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E9" subjects_affected="7" subjects_at_risk="16"/>
                <counts group_id="E10" subjects_affected="4" subjects_at_risk="6"/>
                <counts group_id="E11" subjects_affected="5" subjects_at_risk="6"/>
                <counts group_id="E12" subjects_affected="19" subjects_at_risk="25"/>
                <counts group_id="E13" subjects_affected="6" subjects_at_risk="7"/>
                <counts group_id="E14" subjects_affected="10" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Congenital, familial and genetic disorders</title>
            <event_list>
              <event>
                <sub_title>Bicuspid aortic valve</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Gastrointestinal disorders</title>
            <event_list>
              <event>
                <sub_title>Diarrhoea</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E5" events="2" subjects_affected="2" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="1" subjects_affected="1" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Vomiting</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="2" subjects_affected="2" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Abdominal pain</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Faeces discoloured</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="1" subjects_affected="1" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Faeces pale</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Faeces soft</sub_title>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Abdominal distension</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Constipation</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="2" subjects_affected="2" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Nausea</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Aphthous ulcer</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Glossodynia</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Lip dry</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Lip ulceration</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Mouth ulceration</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>General disorders</title>
            <event_list>
              <event>
                <sub_title>Catheter site pain</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Chest pain</sub_title>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Vessel puncture site bruise</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="1" subjects_affected="1" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Fatigue</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="2" subjects_affected="2" subjects_at_risk="6"/>
                <counts group_id="E11" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="2" subjects_affected="2" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Catheter site bruise</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Feeling cold</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Mass</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Infections and infestations</title>
            <event_list>
              <event>
                <sub_title>Nasopharyngitis</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Viral infection</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Oral herpes</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Upper respiratory tract infection</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Abscess</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Folliculitis</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Hordeolum</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Injury, poisoning and procedural complications</title>
            <event_list>
              <event>
                <sub_title>Contusion</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E12" events="3" subjects_affected="3" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Face injury</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="1" subjects_affected="1" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Limb injury</sub_title>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Skin abrasion</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Arthropod bite</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="2" subjects_affected="2" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Investigations</title>
            <event_list>
              <event>
                <sub_title>Transaminases increased</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="1" subjects_affected="1" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Musculoskeletal and connective tissue disorders</title>
            <event_list>
              <event>
                <sub_title>Musculoskeletal pain</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Back pain</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E12" events="2" subjects_affected="2" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="2" subjects_affected="2" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Musculoskeletal stiffness</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Muscle twitching</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Myalgia</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Nervous system disorders</title>
            <event_list>
              <event>
                <sub_title>Headache</sub_title>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E5" events="2" subjects_affected="2" subjects_at_risk="6"/>
                <counts group_id="E6" events="2" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E7" events="2" subjects_affected="2" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="1" subjects_affected="1" subjects_at_risk="16"/>
                <counts group_id="E10" events="3" subjects_affected="3" subjects_at_risk="6"/>
                <counts group_id="E11" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E12" events="5" subjects_affected="3" subjects_at_risk="25"/>
                <counts group_id="E13" events="2" subjects_affected="2" subjects_at_risk="7"/>
                <counts group_id="E14" events="6" subjects_affected="6" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Dizziness</sub_title>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E2" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="2" subjects_affected="2" subjects_at_risk="6"/>
                <counts group_id="E12" events="2" subjects_affected="2" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Migraine</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Paraesthesia</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Lethargy</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Disturbance in attention</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Somnolence</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Psychiatric disorders</title>
            <event_list>
              <event>
                <sub_title>Nightmare</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="1" subjects_affected="1" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Depression</sub_title>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Insomnia</sub_title>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Agitation</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Abnormal dreams</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="2" subjects_affected="2" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Depressed mood</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Respiratory, thoracic and mediastinal disorders</title>
            <event_list>
              <event>
                <sub_title>Nasal obstruction</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="2" subjects_affected="2" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Cough</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Haemoptysis</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Oropharyngeal pain</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Epistaxis</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Hiccups</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Skin and subcutaneous tissue disorders</title>
            <event_list>
              <event>
                <sub_title>Dermatitis contact</sub_title>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E2" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E3" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E7" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="1" subjects_affected="1" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="7" subjects_affected="7" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Dry skin</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Rash</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="1" subjects_affected="1" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Blister</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="0" subjects_affected="0" subjects_at_risk="7"/>
                <counts group_id="E14" events="1" subjects_affected="1" subjects_at_risk="14"/>
              </event>
              <event>
                <sub_title>Eczema nummular</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E3" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E4" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E5" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E6" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E7" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E8" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E9" events="0" subjects_affected="0" subjects_at_risk="16"/>
                <counts group_id="E10" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E11" events="0" subjects_affected="0" subjects_at_risk="6"/>
                <counts group_id="E12" events="0" subjects_affected="0" subjects_at_risk="25"/>
                <counts group_id="E13" events="1" subjects_affected="1" subjects_at_risk="7"/>
                <counts group_id="E14" events="0" subjects_affected="0" subjects_at_risk="14"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </other_events>
    </reported_events>

    <certain_agreements>
      <pi_employee>Principal Investigators are NOT employed by the organization sponsoring the study.</pi_employee>
      <restrictive_agreement>GSK agreements may vary with individual investigators, but will not prohibit any investigator from publishing. GSK supports the publication of results from all centers of a multi-center trial but requests that reports based on single-site data not precede the primary publication of the entire clinical trial.</restrictive_agreement>
    </certain_agreements>
    <point_of_contact>
      <name_or_title>GSK Response Center</name_or_title>
      <organization>ViiV Healthcare</organization>
      <phone>866-435-7343</phone>
      <email>GSKClinicalSupportHD@gsk.com</email>
    </point_of_contact>
  </clinical_results>
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03231943
org study id: 207187
secondary id: 2017-001367-21
nct id: NCT03231943
lead sponsor: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Human immuno deficiency virus 1 (HIV-1) infections continues to be a serious health threat
      throughout the world and development of medicines with new mechanism of action have an
      important role to play. GSK3640254 is a maturation inhibitor (MI) and can be effective in
      HIV-1 treatment. This randomized, 2-part, single and repeat increasing dose study will
      collect information on safety, tolerability and drug levels in the body of in healthy
      subjects for GSK3640254. The information collected in this study will help in further
      clinical development of GSK3640254, including a Phase IIA Proof of Concept (PoC) study in
      HIV-infected subjects. Approximately 16 healthy subjects will be randomized to receive single
      oral dose of GSK3640254 and placebo in Part 1 and approximately 56 healthy subjects will be
      randomized to receive repeat oral dose of GSK3640254 or placebo in Part 2. All doses will be
      given immediately after a moderate fat meal. Maximum duration of study participation will be
      approximately 12 weeks.
allocation: Randomized
intervention model: Sequential Assignment
intervention model description: This is a dose-escalation study and dose will be escalated based on the safety data of the initial dose.
primary purpose: Treatment
masking: Double (Participant, Investigator)
masking description: This will be a double-blind study with subjects and the site-staff blinded and sponsor unblinded.
measure: Part 1:Number of Participants With Adverse Events (AEs) and Serious AEs (SAEs)
time frame: Up to Day 15
description: An AE is any untoward medical occurrence in a subject, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product. Any untoward event resulting in death, life threatening, requires hospitalization or prolongation of existing hospitalization, results in disability/incapacity, congenital anomaly/birth defect or any other situation according to medical or scientific judgment will be categorized as SAE. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Hematology Parameters: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils, Platelets.
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the hematology parameters: basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Hematology Parameters: Erythrocytes.
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the hematology parameters: erythrocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.Results are presented treatment wise.
measure: Part 1: Change From Baseline in Hematology Parameters: Erythrocytes Mean Corpuscular Volume (Erythrocyte MCV).
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the hematology parameters: erythrocyte MCV. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.
measure: Part 1: Change From Baseline in Hematology Parameter: Erythrocytes Mean Corpuscular Hemoglobin (Erythrocyte MCH)
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the hematology parameter: Erythrocyte MCH. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.Results are presented treatment wise.
measure: Part 1: Change From Baseline in Hematology Parameter: Hematocrit
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the hematology parameter: hematocrit. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Hematology Parameter: Percentage of Reticulocytes
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the hematology parameter: percentage of reticulocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Hematology Parameter: Hemoglobin (Hb)
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the hematology parameter: Hb. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Clinical Chemistry Parameter: Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphate (ALP)
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the chemistry parameter: ALT, AST, and ALP. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Clinical Chemistry Parameters : Bicarbonate, Calcium, Chloride, Magnesium, Phosphate, Potassium, Sodium, Urea
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the chemistry parameter: bicarbonate, calcium, chloride, magnesium, phosphate, potassium, sodium, urea. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Cholesterol, Glucose, High Density Lipoprotein (HDL) Cholesterol, Low Density Cholesterol (LDL) Cholesterol, Triglycerides
time frame: Baseline (Day -2) and Day 1 (96 hours) and Follow up (Day 15)
description: Blood samples were collected to analyze the chemistry parameter: cholesterol, glucose, HDL cholesterol, LDL cholesterol, triglycerides. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Chemistry Parameter: Glucose
time frame: Baseline (Day -2) and Day 1 (96 hours) and Follow up (Day 15)
description: Blood samples were collected to analyze the chemistry parameter: glucose . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Clinical Chemistry Parameter: Bilirubin, Creatinine, Direct Bilirubin
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the chemistry parameter: bilirubin, creatinine, direct bilirubin . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Clinical Chemistry Parameter: Protein
time frame: Baseline (Day -2), 24 hours, 48 hours, 96 hours and Follow up (Day 15)
description: Blood samples were collected to analyze the chemistry parameter: Protein. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.
measure: Part 1: Number of Participants With Abnormal Urinalysis
time frame: Up to Day 15
description: Urine samples were collected at given time points to analyze the abnormal findings for potential of hydrogen (pH), glucose, protein, blood, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase by dipstick.
measure: Part 1: Change From Baseline in Vital Signs: Diastolic Blood Pressure (DBP) and Systolic Blood Pressure (SBP)
time frame: Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)
description: SBP and DBP were measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Vital Signs: Pulse Rate
time frame: Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)
description: Pulse rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Vital Signs: Temperature
time frame: Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)
description: Temperature was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Vital Sign: Respiratory Rate
time frame: Baseline (Day -1), 1,2,4.5,6,12,24,48,72,96 hours post dose and Follow up (Day 15)
description: Respiratory rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Number of Participants With Abnormal Electrocardiogram (ECG) Findings
time frame: Baseline (Day 1 predose), 1,2,4,6,12,24,48,72,96 hours post dose and Follow up (Day 15)
description: 12-lead ECGs were measured in a semi-supine position using an automated ECG machine after approximately 5 minutes of rest for the participant. Abnormal findings were categorized as clinically significant (CS) and not clinically significant (NCS).
measure: Part 2: Number of Participants AEs and SAEs
time frame: Up to Day 28
description: An AE is any untoward medical occurrence in a participant, temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product. Any untoward event resulting in death, life threatening, requires hospitalization or prolongation of existing hospitalization, results in disability/incapacity, congenital anomaly/birth defect or any other situation according to medical or scientific judgment were categorized as SAE. Results are presented treatment wise.
measure: Part 2: Change From Baseline in Abnormal Hematology Findings: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils, Platelets.
time frame: Baseline (Day -2), Pre dose on Days 2,4,6,8,10,12,14 Day 14 : 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected at indicated time points to analyze the hematology parameters: basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Change From Baseline in Hematology Parameter: Erythrocytes
time frame: Baseline (Day -2), Pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected at indicated time points to analyze the hematology parameters: Erythrocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.
measure: Part 2: Change From Baseline in Hematology Parameter: Erythrocytes MCV
time frame: Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected at indicated time points to analyze the hematology parameters: Erythrocyte MCV. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.
measure: Part 2: Change From Baseline in Hematology Parameter: Erythrocytes Mean Corpuscular Hemoglobin (Erythrocyte MCH)
time frame: Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected at indicated time points to analyze the hematology parameter: Erythrocyte MCH. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.
measure: Part 2: Change From Baseline in Hematology Parameter: Hematocrit
time frame: Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected at indicated time points to analyze the hematology parameter: hematocrit. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Change From Baseline in Hematology Parameter: Percentage of Reticulocytes
time frame: Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected to analyze the hematology parameter: percentage of reticulocytes. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Change From Baseline in Hematology Parameter: Hb
time frame: Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected at indicated time points to analyze the hematology parameter: Hb. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.
measure: Part 2: Change From Baseline in Chemistry Parameter: ALT, AST,ALP
time frame: Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected to analyze the chemistry parameter: ALT, AST,ALP. Day -2was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 1: Change From Baseline in Bicarbonate, Calcium, Chloride, Cholesterol, Magnesium, Phosphate, Potassium, Sodium, Urea
time frame: Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected to analyze the chemistry parameter: bicarbonate, calcium, chloride, magnesium, phosphate, potassium, sodium, urea. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.
measure: Part 2: Change From Baseline in Cholesterol, HDL Cholesterol, LDL Cholesterol, Triglycerides
time frame: Baseline (Day -2), Day 8 (pre dose), Day 14 (48 hours) post dose and Follow up (Day 28)
description: Blood samples were collected at indicated time points to analyze the chemistry parameter: cholesterol, HDL cholesterol, LDL cholesterol, triglycerides. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Change From Baseline in Chemistry Parameter: Glucose
time frame: Baseline (Day -2), Day 8 (predose), Day 14 (48 hours) post dose and Follow up (Day 28)
description: Blood samples were collected at indicated time points to analyze the chemistry parameter: glucose . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Change From Baseline in Chemistry Parameter: Bilirubin, Creatinine, Direct Bilirubin
time frame: Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected to analyze the chemistry parameter: bilirubin, creatinine, direct bilirubin . Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Change From Baseline in Chemistry Parameter: Protein
time frame: Baseline (Day -2), pre dose on Days 2,4,6,8,10,12,14 Day 14: 48 and 96 hours post dose, Follow up (Day 28)
description: Blood samples were collected to analyze the chemistry parameter: Protein. Day -2 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Number of Participants With Abnormal Urinalysis
time frame: Up to Day 28
description: Urine samples were collected analyze the abnormal findings for potential of hydrogen (pH), glucose, protein, blood, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase by dipstick.
measure: Part 2: Change From Baseline in Vital Signs: SBP and DBP
time frame: Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12,and 14 (pre dose and 72 hours) and Follow up (Day 28)
description: SBP and DBP were measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Change From Baseline in Vital Sign: Pulse Rate
time frame: Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12, and 14 (pre dose and 72 hours) and Follow up (Day 28)
description: Pulse rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value.
measure: Part 2: Change From Baseline in Vital Sign: Temperature
time frame: Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12, and 14 (pre dose and 72 hours) and Follow up (Day 28)
description: Temperature was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Change From Baseline in Vital Sign: Respiratory Rate
time frame: Baseline (Day -1), pre dose on Days 1,2,4,6,8,10,12 and 14 (pre dose and 72 hours) and Follow up (Day 28)
description: Respiratory rate was measured in semi-supine position after 5 minutes rest for the participants at indicated time points. Day -1 was considered as Baseline. Change from Baseline was calculated by subtracting Baseline value from the specified time point value. Results are presented treatment wise.
measure: Part 2: Number of Participants With Abnormal ECG Findings
time frame: Day 1 (0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4.5, 5, 5.5, 6, 8, 12, 24 hours); Pre-dose on Days 3, 4, 6, 8, 10, 12; Day 14: Pre-dose, 1, 2, 4.5, 5, 6, 12, 24, 48, 72 and 96 hours post-dose and follow up (Day 28)
description: 12-lead ECG were obtained at given time points. Abnormal findings were categorized as clinically significant (CS) and not clinically significant (NCS).Results are presented treatment wise.
measure: Part 1: Area Under the Plasma Concentration Time Curve (AUC) From Zero to 24 Hour (AUC[0-24]) of GSK3640254
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12,24 hours post-dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 1: AUC From Zero to Time of Last Sample Taken (AUC[0-Tlast]) of GSK3640254
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 1: AUC From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC[0-inf]) of GSK3640254
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 1: Apparent Terminal Phase Half-life (T1/2) of GSK3640254
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Most of the concentrations were below limit of quantification (BLQ) at this dose group this value and/ or %AUC extrapolated was >20% for all participants so this value should be used with caution. Results are presented treatment wise.
measure: Part 1: Apparent Oral Clearance (CL/F) of GSK3640254
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 1: Maximum Observed Concentration (Cmax), Concentration of GSK3640254 at 24 Hours (C24) and Last Quantifiable Concentration (Clast) of GSK3640254
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.
measure: Part 1: Time of Occurrence of Cmax (Tmax), Lag Time (Tlag), and Time to Reach Clast (Tlast) of GSK3640254
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12, 24, 48, 72 and 96 hours post-dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 2: AUC(0-24) of GSK3640254: Day 1
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12 and 24 hours post-dose on Day 1
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 2: Cmax, C24 of GSK3640254 on Day 1
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12 hours post-dose on Day 1
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 2: Tmax, Tlag of GSK3640254 on Day 1
time frame: Pre-dose and 0.5,1,1.5,2,2.5,3,3.5,4,4.5,5,6,8,12 hours post-dose on Day 1
description: Blood samples were collected at indicated timepoints and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.
measure: Part 2: Tmax GSK3640254 on Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 2: Cmax of GSK3640254 on Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 2: AUC From Pre-dose to the End of the Dosing Interval at Steady State (AUC[0-tau]): Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 2: Plasma Trough Concentration (Ctau) of GSK3640254: Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated timepoints and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The PK parameter name for Part 2 (Day 14) trough concentration was changed using Phoenix WinNonlin 8 from Ct to Ctrough. Day 15 Ctrough values were used for dose proportionality and time to steady-state assessments.
measure: Part 2: T1/2 of GSK3640254: Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. Results are presented treatment wise.
measure: Part 2: CL/F of GSK3640254: Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin.
measure: Part 1: Dose Proportionality (AUC[0-inf]) Following Single Dose of GSK3640254 on Day 1
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose
description: Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.
measure: Part 1: Dose Proportionality (AUC0-24) Following Single Dose of GSK3640254 on Day 1
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24 hours post dose
description: Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.
measure: Part 1: Dose Proportionality for Cmax Following Single Dose of GSK3640254 on Day 1
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose
description: Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.
measure: Part 2: Dose Proportionality (AUC0-tau) Following Repeated Dose of GSK3640254 on Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.
measure: Part 2: Dose Proportionality (Ctrough) Following Repeated Dose of GSK3640254 on Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.
measure: Part 2: Dose Proportionality (Cmax) Following Repeated Dose of GSK3640254 on Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.
measure: Part 2: Accumulation Ratio of AUC(0-tau) (R [AUC{0-TAU}]) From Day 1 to Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 14 and Day 1, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.
measure: Part 2: Accumulation Ratio of Cmax (R [CMAX]) From Day 1 to Day 14
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 14 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 14 and Day 1, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.
measure: Part 2: Accumulation Ratio of C(Tau) (R[CTAU]) From Day 2 to Day 15
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours after Day 15 dose
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. The accumulation ratio was estimated by calculating the ratio of the geometric least squares (GLS) means of PK parameters between Day 15 and Day 2, and the corresponding 90% CI for each dose. Ratio and 90% confidence interval is presented. Results are presented treatment wise.
measure: Part 2: Pre-dose Concentration of GSK3640254 on Day 2 to Day 14
time frame: Pre-dose on Days 2,3,4,6,8,10,12 and 14
description: Blood samples were collected at indicated time points and PK analysis was performed. PK parameters were determined by non-compartmental methods with Phoenix WinNonlin. results are presented treatment wise.
measure: Part 2: Dose Proportionality (Cmax) Following Repeated Dose of GSK3640254 at Day 1
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose
description: Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.
measure: Part 2: Dose Proportionality (AUC0-24) Following Repeated Dose of GSK3640254 at Day 1
time frame: Pre-dose and 0.5,1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 8, 12, 24, 48, 72 and 96 hours post dose
description: Blood samples were collected at indicated time points and PK analysis was performed. Dose proportionality was assessed using the power model. Results are presented treatment wise.
arm group label: Subjects in cohort 1-2: Part 1
arm group type: Experimental
description: Eligible subjects will participate in cohort 1 or 2 and each of these two cohorts will contain up to four escalating doses of GSK3640254. In each cohort, 6 subjects will be randomized to receive single oral dose of GSK3640254 and 2 subjects will be randomized to receive placebo. Hence, each subject in cohort 1 and 2 will receive up to 3 escalating doses of GSK3640254 and one placebo in crossover manner.
arm group label: GSK3640254 receivers (cohort 3-6 and expansion): Part 2
arm group type: Experimental
description: Eligible subjects will participate in one of the 4 cohorts (3,4,5,6). In each cohort, 6 subjects will be randomized to receive a once-daily oral dose of GSK3640254 for 14 days. After the safety data of cohort 3-6 is available, 18 eligible subjects will be randomized to receive once daily oral dose of GSK3640254 for 14 days in expansion cohort.
arm group label: Subjects receiving placebo (cohort 3-6): Part 2
arm group type: Placebo Comparator
description: Eligible subjects will participate in one of the 4 cohorts (3,4,5,6). In each cohort, 2 subjects will be randomized to receive a once-daily oral dose of placebo for 14 days. After the safety data of cohort 3-6 is available, 6 eligible subjects will be randomized to receive once daily oral dose of placebo for 14 days in expansion cohort.
intervention type: Drug
intervention name: GSK3640254
description: GSK3640254 is a capsule available in 1 milligram (mg), 10 mg and 100 mg dosing strength. GSK3640254 capsule will be given via oral route during each dosing day with approximately 240 mL of water.
arm group label: GSK3640254 receivers (cohort 3-6 and expansion): Part 2
arm group label: Subjects in cohort 1-2: Part 1
intervention type: Drug
intervention name: Placebo
description: Placebo capsule matching to the study treatment will be given via oral route during each dosing day with approximately 240 mL of water.
arm group label: Subjects in cohort 1-2: Part 1
arm group label: Subjects receiving placebo (cohort 3-6): Part 2
criteria: 
gender: All
minimum age: 18 Years
maximum age: 55 Years
healthy volunteers: Accepts Healthy Volunteers
last name: GSK Clinical Trials
role: Study Director
affiliation: ViiV Healthcare
facility: 
country: United Kingdom
citation: Joshi SR, Fernando D, Igwe S, McKenzie L, Krishnatry AS, Halliday F, Zhan J, Greene TJ, Xu J, Ferron-Brady G, Lataillade M, Min S. Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next-generation HIV-1 maturation inhibitor. Pharmacol Res Perspect. 2020 Dec;8(6):e00671. doi: 10.1002/prp2.671.
PMID: 33200887
responsible party type: Sponsor
mesh term: Infections
mesh term: Communicable Diseases
mesh term: HIV Infections
mesh term: Acquired Immunodeficiency Syndrome
sharing ipd: Yes
ipd description: IPD for this study is available via the Clinical Study Data Request site.
ipd info type: Study Protocol
ipd info type: Statistical Analysis Plan (SAP)
ipd info type: Informed Consent Form (ICF)
ipd info type: Clinical Study Report (CSR)
ipd time frame: IPD is available via the Clinical Study Data Request site (copy the URL below to your browser)
ipd access criteria: Access is provided after a research proposal is submitted and has received approval from the Independent Review Panel and after a Data Sharing Agreement is in place. Access is provided for an initial period of 12 months but an extension can be granted, when justified, for up to another 12 months.
ipd url: https://clinicalstudydatarequest.com/Posting.aspx?ID=20826
provided document: 
provided document: 
participant flow: 
baseline: 
outcome list: 
reported events: 
certain agreements: 
point of contact: 