<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03295279</url>
  </required_header>
  <id_info>
    <org_study_id>GCO 12-0751</org_study_id>
    <secondary_id>U01OH010401</secondary_id>
    <secondary_id>U01OH011697</secondary_id>
    <secondary_id>GCO 17-2598</secondary_id>
    <nct_id>NCT03295279</nct_id>
  </id_info>
  <brief_title>WTC Chest CT Imaging Archive</brief_title>
  <official_title>Pulmonary Diseases in WTC Workers: Symptoms, Function, and Chest CT Correlates</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Icahn School of Medicine at Mount Sinai</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>University of Pittsburgh</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Brigham and Women's Hospital</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>National Jewish Health</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>University of New Mexico</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Icahn School of Medicine at Mount Sinai</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted&#xD;
      readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai&#xD;
      Medical Center between 2003 and 2016. The clinical team sought to assess all findings&#xD;
      suggestive of airway, interstitial, and neoplastic disease in a systematic way, and correlate&#xD;
      those findings with clinical, functional, and exposure indicators. The study team's research&#xD;
      will also involve analyses of longitudinal imaging and functional trends, and&#xD;
      characterization of the WTC related lower airway diseases and their risk factors, with a&#xD;
      focus on obesity-related imaging markers. The study team also plans to characterize the&#xD;
      transitions into chronic obstructive pulmonary disease (COPD) among these workers.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The goal of this proposal is to characterize WTC-related lower airway disorders, and use&#xD;
      novel imaging approaches to the investigation of obesity, one of their most important risk&#xD;
      factors for poor clinical outcome and chronicity. To that end, the clinical team will utilize&#xD;
      the WTC Pulmonary Evaluation Unit Chest CT Imaging Archive, an already established large&#xD;
      imaging database, linked to extensive related databases that include disease symptoms, both&#xD;
      pre-WTC and WTC-related occupational exposures, detailed pulmonary function and longitudinal&#xD;
      spirometry measurements, visual imaging classification and grading, and quantitative computer&#xD;
      assisted method (QCAM) measurements of airway, pulmonary parenchymal, pleural, and&#xD;
      cardiovascular abnormalities. During the course of the proposed research project, the&#xD;
      clinical team will continue to enrich most sources of data with periodic updates, in order to&#xD;
      accrue information on the trajectories of the different clinical, functional, and imaging&#xD;
      abnormalities observed in this population, and investigate the role of key adverse risk&#xD;
      factors directly, and in collaboration with other investigators. In a related project, the&#xD;
      research team will focus on COPD, classifying its severity, investigating its diagnostic&#xD;
      stability, progression, and transitions, characterize structural abnormalities as assessed by&#xD;
      chest CT imaging, and examine the interaction of WTC-related exposure levels with tobacco&#xD;
      smoking on increasing the risk of for the disease.&#xD;
&#xD;
      Grant U01 OH010401 was renewed to 6/30/2026. Renewal of grant U01 OH011697 is pending funding&#xD;
      decision.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Active, not recruiting</overall_status>
  <start_date type="Actual">January 15, 2012</start_date>
  <completion_date type="Anticipated">June 2026</completion_date>
  <primary_completion_date type="Anticipated">June 2026</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Retrospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Accelerated longitudinal FEV1 decline</measure>
    <time_frame>5 years</time_frame>
    <description>The clinical team selects spirometries of acceptable quality, and subjects with at least 3 spirometries spanning at least 5 years, to calculate FEV1 slope, which can then be modeled quantitatively. For categorical analyses, the clinical team defines rapid FEV1 decliners and contrast them to normal-and-stable FEV1 subjects, defined as those having an FEV1 above the lower limit of normal at baseline, no bronchodilator response, and FEV1 not changing by more than 25 ml/year on average in either direction.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Number of physician diagnosis of incident asthma</measure>
    <time_frame>5 years</time_frame>
    <description>Physician diagnosis of asthma with onset after WTC occupational exposures.</description>
  </secondary_outcome>
  <enrollment type="Actual">1722</enrollment>
  <condition>Chronic Airway Disease</condition>
  <condition>Interstitial Lung Disease</condition>
  <condition>Lung Cancer</condition>
  <eligibility>
    <study_pop>
      <textblock>
        All subjects will be participants in the screening/monitoring (SMP) and treatment program&#xD;
        (TP) sides of the WTC Health Plan Clinical Center Excellence at Mount Sinai Medical Center,&#xD;
        the major site, by far of the NY/NJ consortium of this program.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  All subjects will be participants in the screening/monitoring (SMP) and treatment&#xD;
             program (TP) sides of the WTC Health Plan Clinical Center Excellence at Mount Sinai&#xD;
             Medical Center, the major site, by far of the NY/NJ consortium of this program.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Special vulnerable populations, such as fetuses, neonates, pregnant women, children,&#xD;
             prisoners, institutionalized individuals, will not be involved in this research study.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Rafael E. de la Hoz, MD, MPH, MSc</last_name>
    <role>Principal Investigator</role>
    <affiliation>Icahn School of Medicine at Mount Sinai</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Icahn School of Medicine at Mount Sinai</name>
      <address>
        <city>New York</city>
        <state>New York</state>
        <zip>10029</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <link>
    <url>https://wwwn.cdc.gov/ResearchGateway/ResearchProjects/Details/140</url>
    <description>CDC/NIOSH Project Profile</description>
  </link>
  <link>
    <url>https://wwwn.cdc.gov/ResearchGateway/ResearchProjects/Details/146</url>
    <description>CDC/NIOSH Project Profile</description>
  </link>
  <link>
    <url>http://www.mountsinai.org/profiles/rafael-e-de-la-hoz</url>
    <description>Principal investigator's academic web page</description>
  </link>
  <link>
    <url>http://orcid.org/0000-0002-8949-9279/print</url>
    <description>Principal investigator's ORCID record</description>
  </link>
  <link>
    <url>https://wwwn.cdc.gov/ResearchGateway/ResearchProjects/Details/32</url>
    <description>CDC/NIOSH Project Profile</description>
  </link>
  <link>
    <url>https://www.ncbi.nlm.nih.gov/sites/myncbi/1t5YX2bFtgN/collections/58762945/public/</url>
    <description>PrincipaI investigator's WTC-related bibliography</description>
  </link>
  <reference>
    <citation>de la Hoz RE, Weissman DN. Consideration of Occupational and Environmental Lung Carcinogen Exposures for Lung Cancer Screening Using Low-Dose Chest CT. Chest. 2018 Oct;154(4):996-997. doi: 10.1016/j.chest.2018.07.023. No abstract available.</citation>
    <PMID>30290946</PMID>
  </reference>
  <reference>
    <citation>de la Hoz RE. Occupational lower airway disease in relation to World Trade Center inhalation exposure. Curr Opin Allergy Clin Immunol. 2011 Apr;11(2):97-102. doi: 10.1097/ACI.0b013e3283449063.</citation>
    <PMID>21325944</PMID>
  </reference>
  <reference>
    <citation>de la Hoz RE, Shohet MR, Chasan R, Bienenfeld LA, Afilaka AA, Levin SM, Herbert R. Occupational toxicant inhalation injury: the World Trade Center (WTC) experience. Int Arch Occup Environ Health. 2008 Feb;81(4):479-85. doi: 10.1007/s00420-007-0240-x. Epub 2007 Sep 5.</citation>
    <PMID>17786467</PMID>
  </reference>
  <reference>
    <citation>Mendelson DS, Roggeveen M, Levin SM, Herbert R, de la Hoz RE. Air trapping detected on end-expiratory high-resolution computed tomography in symptomatic World Trade Center rescue and recovery workers. J Occup Environ Med. 2007 Aug;49(8):840-5. doi: 10.1097/JOM.0b013e3180d09e87.</citation>
    <PMID>17693781</PMID>
  </reference>
  <reference>
    <citation>de la Hoz RE, Hill S, Chasan R, Bienenfeld LA, Afilaka AA, Wilk-Rivard E, Herbert R. Health care and social issues of immigrant rescue and recovery workers at the World Trade Center site. J Occup Environ Med. 2008 Dec;50(12):1329-34. doi: 10.1097/JOM.0b013e31818ff6fd.</citation>
    <PMID>19092486</PMID>
  </reference>
  <reference>
    <citation>de la Hoz RE, Christie J, Teamer JA, Bienenfeld LA, Afilaka AA, Crane M, Levin SM, Herbert R. Reflux symptoms and disorders and pulmonary disease in former World Trade Center rescue and recovery workers and volunteers. J Occup Environ Med. 2008 Dec;50(12):1351-4. doi: 10.1097/JOM.0b013e3181845f9b. Erratum In: J Occup Environ Med. 2009 Apr;51(4):509.</citation>
    <PMID>19092489</PMID>
  </reference>
  <reference>
    <citation>Brite J, Friedman S, de la Hoz RE, Reibman J, Cone J. Mental health, long-term medication adherence, and the control of asthma symptoms among persons exposed to the WTC 9/11 disaster. J Asthma. 2020 Nov;57(11):1253-1262. doi: 10.1080/02770903.2019.1672722. Epub 2019 Oct 10.</citation>
    <PMID>31550944</PMID>
  </reference>
  <results_reference>
    <citation>Napier CO, Mbadugha O, Bienenfeld LA, Doucette JT, Lucchini R, Luna-Sanchez S, de la Hoz RE. Obesity and weight gain among former World Trade Center workers and volunteers. Arch Environ Occup Health. 2017 Mar 4;72(2):106-110. doi: 10.1080/19338244.2016.1197174. Epub 2016 Jun 7.</citation>
    <PMID>27268046</PMID>
  </results_reference>
  <results_reference>
    <citation>de la Hoz RE, Jeon Y, Miller GE, Wisnivesky JP, Celedon JC. Post-traumatic Stress Disorder, Bronchodilator Response, and Incident Asthma in World Trade Center Rescue and Recovery Workers. Am J Respir Crit Care Med. 2016 Dec 1;194(11):1383-1391. doi: 10.1164/rccm.201605-1067OC.</citation>
    <PMID>27548615</PMID>
  </results_reference>
  <results_reference>
    <citation>de la Hoz RE, Liu X, Doucette JT, Reeves AP, Bienenfeld LA, Wisnivesky JP, Celedon JC, Lynch DA, San Jose Estepar R. Increased Airway Wall Thickness is Associated with Adverse Longitudinal First-Second Forced Expiratory Volume Trajectories of Former World Trade Center workers. Lung. 2018 Aug;196(4):481-489. doi: 10.1007/s00408-018-0125-7. Epub 2018 May 24.</citation>
    <PMID>29797069</PMID>
  </results_reference>
  <results_reference>
    <citation>de la Hoz RE, Weber J, Xu D, Doucette JT, Liu X, Carson DA, Celedon JC. Chest CT scan findings in World Trade Center workers. Arch Environ Occup Health. 2019;74(5):263-270. doi: 10.1080/19338244.2018.1452712. Epub 2018 May 9. Erratum In: Arch Environ Occup Health. 2019 Sep 27;:1-2.</citation>
    <PMID>29543564</PMID>
  </results_reference>
  <results_reference>
    <citation>de la Hoz RE, Jeon Y, Reeves AP, San Jose Estepar R, Liu X, Doucette JT, Celedon JC, Nolan A. Increased pulmonary artery diameter is associated with reduced FEV1 in former World Trade Center workers. Clin Respir J. 2019 Oct;13(10):614-623. doi: 10.1111/crj.13067. Epub 2019 Aug 19.</citation>
    <PMID>31347281</PMID>
  </results_reference>
  <results_reference>
    <citation>de la Hoz RE, Liu X, Celedon JC, Doucette JT, Jeon Y, Reeves AP, San Jose Estepar R. Association of Obesity with Quantitative Chest CT Measured Airway Wall Thickness in WTC Workers with Lower Airway Disease. Lung. 2019 Aug;197(4):517-522. doi: 10.1007/s00408-019-00246-z. Epub 2019 Jun 28.</citation>
    <PMID>31254057</PMID>
  </results_reference>
  <results_reference>
    <citation>Haghighi A, Cone JE, Li J, de la Hoz RE. Asthma-COPD overlap in World Trade Center Health Registry enrollees, 2015-2016. J Asthma. 2021 Nov;58(11):1415-1423. doi: 10.1080/02770903.2020.1817935. Epub 2020 Sep 15.</citation>
    <PMID>32930623</PMID>
  </results_reference>
  <results_reference>
    <citation>Sigel KM, Xu D, Weber J, Wisnivesky JP, Celedon JC, de la Hoz RE. Prevalence of Pulmonary Nodules Detected by Computed Tomography in World Trade Center Rescue and Recovery Workers. Ann Am Thorac Soc. 2020 Jan;17(1):125-128. doi: 10.1513/AnnalsATS.201907-517RL. No abstract available.</citation>
    <PMID>31499008</PMID>
  </results_reference>
  <results_reference>
    <citation>Weber J, Reeves AP, Doucette JT, Jeon Y, Sood A, San Jose Estepar R, Celedon JC, de la Hoz RE. Quantitative CT Evidence of Airway Inflammation in WTC Workers and Volunteers with Low FVC Spirometric Pattern. Lung. 2020 Jun;198(3):555-563. doi: 10.1007/s00408-020-00350-5. Epub 2020 Apr 1.</citation>
    <PMID>32239319</PMID>
  </results_reference>
  <results_reference>
    <citation>de la Hoz RE, Shapiro M, Nolan A, Celedon JC, Szeinuk J, Lucchini RG. Association of low FVC spirometric pattern with WTC occupational exposures. Respir Med. 2020 Aug-Sep;170:106058. doi: 10.1016/j.rmed.2020.106058. Epub 2020 Jun 7.</citation>
    <PMID>32843177</PMID>
  </results_reference>
  <verification_date>April 2023</verification_date>
  <study_first_submitted>September 25, 2017</study_first_submitted>
  <study_first_submitted_qc>September 25, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">September 27, 2017</study_first_posted>
  <last_update_submitted>April 13, 2023</last_update_submitted>
  <last_update_submitted_qc>April 13, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">April 18, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Icahn School of Medicine at Mount Sinai</investigator_affiliation>
    <investigator_full_name>Rafael E. de la Hoz</investigator_full_name>
    <investigator_title>Professor</investigator_title>
  </responsible_party>
  <keyword>World Trade Center</keyword>
  <keyword>Quantitative computerized tomography</keyword>
  <keyword>Qualitative computerized tomography of the chest</keyword>
  <keyword>Chronic airway disease</keyword>
  <keyword>Interstitial lung disease</keyword>
  <keyword>Occupational pulmonology</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Lung Diseases</mesh_term>
    <mesh_term>Lung Diseases, Interstitial</mesh_term>
    <mesh_term>Pulmonary Disease, Chronic Obstructive</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03295279
org study id: GCO 12-0751
secondary id: U01OH010401
secondary id: U01OH011697
secondary id: GCO 17-2598
nct id: NCT03295279
lead sponsor: 
collaborator: 
collaborator: 
collaborator: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
Dr. Rafael E de la Hoz and colleagues have performed standardized and computer-assisted
      readings of all chest CT scans received by WTC workers and volunteers at the Mount Sinai
      Medical Center between 2003 and 2016. The clinical team sought to assess all findings
      suggestive of airway, interstitial, and neoplastic disease in a systematic way, and correlate
      those findings with clinical, functional, and exposure indicators. The study team's research
      will also involve analyses of longitudinal imaging and functional trends, and
      characterization of the WTC related lower airway diseases and their risk factors, with a
      focus on obesity-related imaging markers. The study team also plans to characterize the
      transitions into chronic obstructive pulmonary disease (COPD) among these workers.
The goal of this proposal is to characterize WTC-related lower airway disorders, and use
      novel imaging approaches to the investigation of obesity, one of their most important risk
      factors for poor clinical outcome and chronicity. To that end, the clinical team will utilize
      the WTC Pulmonary Evaluation Unit Chest CT Imaging Archive, an already established large
      imaging database, linked to extensive related databases that include disease symptoms, both
      pre-WTC and WTC-related occupational exposures, detailed pulmonary function and longitudinal
      spirometry measurements, visual imaging classification and grading, and quantitative computer
      assisted method (QCAM) measurements of airway, pulmonary parenchymal, pleural, and
      cardiovascular abnormalities. During the course of the proposed research project, the
      clinical team will continue to enrich most sources of data with periodic updates, in order to
      accrue information on the trajectories of the different clinical, functional, and imaging
      abnormalities observed in this population, and investigate the role of key adverse risk
      factors directly, and in collaboration with other investigators. In a related project, the
      research team will focus on COPD, classifying its severity, investigating its diagnostic
      stability, progression, and transitions, characterize structural abnormalities as assessed by
      chest CT imaging, and examine the interaction of WTC-related exposure levels with tobacco
      smoking on increasing the risk of for the disease.

      Grant U01 OH010401 was renewed to 6/30/2026. Renewal of grant U01 OH011697 is pending funding
      decision.
observational model: Cohort
time perspective: Retrospective
measure: Accelerated longitudinal FEV1 decline
time frame: 5 years
description: The clinical team selects spirometries of acceptable quality, and subjects with at least 3 spirometries spanning at least 5 years, to calculate FEV1 slope, which can then be modeled quantitatively. For categorical analyses, the clinical team defines rapid FEV1 decliners and contrast them to normal-and-stable FEV1 subjects, defined as those having an FEV1 above the lower limit of normal at baseline, no bronchodilator response, and FEV1 not changing by more than 25 ml/year on average in either direction.
measure: Number of physician diagnosis of incident asthma
time frame: 5 years
description: Physician diagnosis of asthma with onset after WTC occupational exposures.
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
last name: Rafael E. de la Hoz, MD, MPH, MSc
role: Principal Investigator
affiliation: Icahn School of Medicine at Mount Sinai
facility: 
country: United States
url: https://wwwn.cdc.gov/ResearchGateway/ResearchProjects/Details/140
description: CDC/NIOSH Project Profile
url: https://wwwn.cdc.gov/ResearchGateway/ResearchProjects/Details/146
description: CDC/NIOSH Project Profile
url: http://www.mountsinai.org/profiles/rafael-e-de-la-hoz
description: Principal investigator's academic web page
url: http://orcid.org/0000-0002-8949-9279/print
description: Principal investigator's ORCID record
url: https://wwwn.cdc.gov/ResearchGateway/ResearchProjects/Details/32
description: CDC/NIOSH Project Profile
url: https://www.ncbi.nlm.nih.gov/sites/myncbi/1t5YX2bFtgN/collections/58762945/public/
description: PrincipaI investigator's WTC-related bibliography
citation: de la Hoz RE, Weissman DN. Consideration of Occupational and Environmental Lung Carcinogen Exposures for Lung Cancer Screening Using Low-Dose Chest CT. Chest. 2018 Oct;154(4):996-997. doi: 10.1016/j.chest.2018.07.023. No abstract available.
PMID: 30290946
citation: de la Hoz RE. Occupational lower airway disease in relation to World Trade Center inhalation exposure. Curr Opin Allergy Clin Immunol. 2011 Apr;11(2):97-102. doi: 10.1097/ACI.0b013e3283449063.
PMID: 21325944
citation: de la Hoz RE, Shohet MR, Chasan R, Bienenfeld LA, Afilaka AA, Levin SM, Herbert R. Occupational toxicant inhalation injury: the World Trade Center (WTC) experience. Int Arch Occup Environ Health. 2008 Feb;81(4):479-85. doi: 10.1007/s00420-007-0240-x. Epub 2007 Sep 5.
PMID: 17786467
citation: Mendelson DS, Roggeveen M, Levin SM, Herbert R, de la Hoz RE. Air trapping detected on end-expiratory high-resolution computed tomography in symptomatic World Trade Center rescue and recovery workers. J Occup Environ Med. 2007 Aug;49(8):840-5. doi: 10.1097/JOM.0b013e3180d09e87.
PMID: 17693781
citation: de la Hoz RE, Hill S, Chasan R, Bienenfeld LA, Afilaka AA, Wilk-Rivard E, Herbert R. Health care and social issues of immigrant rescue and recovery workers at the World Trade Center site. J Occup Environ Med. 2008 Dec;50(12):1329-34. doi: 10.1097/JOM.0b013e31818ff6fd.
PMID: 19092486
citation: de la Hoz RE, Christie J, Teamer JA, Bienenfeld LA, Afilaka AA, Crane M, Levin SM, Herbert R. Reflux symptoms and disorders and pulmonary disease in former World Trade Center rescue and recovery workers and volunteers. J Occup Environ Med. 2008 Dec;50(12):1351-4. doi: 10.1097/JOM.0b013e3181845f9b. Erratum In: J Occup Environ Med. 2009 Apr;51(4):509.
PMID: 19092489
citation: Brite J, Friedman S, de la Hoz RE, Reibman J, Cone J. Mental health, long-term medication adherence, and the control of asthma symptoms among persons exposed to the WTC 9/11 disaster. J Asthma. 2020 Nov;57(11):1253-1262. doi: 10.1080/02770903.2019.1672722. Epub 2019 Oct 10.
PMID: 31550944
citation: Napier CO, Mbadugha O, Bienenfeld LA, Doucette JT, Lucchini R, Luna-Sanchez S, de la Hoz RE. Obesity and weight gain among former World Trade Center workers and volunteers. Arch Environ Occup Health. 2017 Mar 4;72(2):106-110. doi: 10.1080/19338244.2016.1197174. Epub 2016 Jun 7.
PMID: 27268046
citation: de la Hoz RE, Jeon Y, Miller GE, Wisnivesky JP, Celedon JC. Post-traumatic Stress Disorder, Bronchodilator Response, and Incident Asthma in World Trade Center Rescue and Recovery Workers. Am J Respir Crit Care Med. 2016 Dec 1;194(11):1383-1391. doi: 10.1164/rccm.201605-1067OC.
PMID: 27548615
citation: de la Hoz RE, Liu X, Doucette JT, Reeves AP, Bienenfeld LA, Wisnivesky JP, Celedon JC, Lynch DA, San Jose Estepar R. Increased Airway Wall Thickness is Associated with Adverse Longitudinal First-Second Forced Expiratory Volume Trajectories of Former World Trade Center workers. Lung. 2018 Aug;196(4):481-489. doi: 10.1007/s00408-018-0125-7. Epub 2018 May 24.
PMID: 29797069
citation: de la Hoz RE, Weber J, Xu D, Doucette JT, Liu X, Carson DA, Celedon JC. Chest CT scan findings in World Trade Center workers. Arch Environ Occup Health. 2019;74(5):263-270. doi: 10.1080/19338244.2018.1452712. Epub 2018 May 9. Erratum In: Arch Environ Occup Health. 2019 Sep 27;:1-2.
PMID: 29543564
citation: de la Hoz RE, Jeon Y, Reeves AP, San Jose Estepar R, Liu X, Doucette JT, Celedon JC, Nolan A. Increased pulmonary artery diameter is associated with reduced FEV1 in former World Trade Center workers. Clin Respir J. 2019 Oct;13(10):614-623. doi: 10.1111/crj.13067. Epub 2019 Aug 19.
PMID: 31347281
citation: de la Hoz RE, Liu X, Celedon JC, Doucette JT, Jeon Y, Reeves AP, San Jose Estepar R. Association of Obesity with Quantitative Chest CT Measured Airway Wall Thickness in WTC Workers with Lower Airway Disease. Lung. 2019 Aug;197(4):517-522. doi: 10.1007/s00408-019-00246-z. Epub 2019 Jun 28.
PMID: 31254057
citation: Haghighi A, Cone JE, Li J, de la Hoz RE. Asthma-COPD overlap in World Trade Center Health Registry enrollees, 2015-2016. J Asthma. 2021 Nov;58(11):1415-1423. doi: 10.1080/02770903.2020.1817935. Epub 2020 Sep 15.
PMID: 32930623
citation: Sigel KM, Xu D, Weber J, Wisnivesky JP, Celedon JC, de la Hoz RE. Prevalence of Pulmonary Nodules Detected by Computed Tomography in World Trade Center Rescue and Recovery Workers. Ann Am Thorac Soc. 2020 Jan;17(1):125-128. doi: 10.1513/AnnalsATS.201907-517RL. No abstract available.
PMID: 31499008
citation: Weber J, Reeves AP, Doucette JT, Jeon Y, Sood A, San Jose Estepar R, Celedon JC, de la Hoz RE. Quantitative CT Evidence of Airway Inflammation in WTC Workers and Volunteers with Low FVC Spirometric Pattern. Lung. 2020 Jun;198(3):555-563. doi: 10.1007/s00408-020-00350-5. Epub 2020 Apr 1.
PMID: 32239319
citation: de la Hoz RE, Shapiro M, Nolan A, Celedon JC, Szeinuk J, Lucchini RG. Association of low FVC spirometric pattern with WTC occupational exposures. Respir Med. 2020 Aug-Sep;170:106058. doi: 10.1016/j.rmed.2020.106058. Epub 2020 Jun 7.
PMID: 32843177
responsible party type: Principal Investigator
investigator affiliation: Icahn School of Medicine at Mount Sinai
investigator full name: Rafael E. de la Hoz
investigator title: Professor
mesh term: Lung Diseases
mesh term: Lung Diseases, Interstitial
mesh term: Pulmonary Disease, Chronic Obstructive
sharing ipd: No