<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03293953</url>
  </required_header>
  <id_info>
    <org_study_id>41UCS2016</org_study_id>
    <nct_id>NCT03293953</nct_id>
  </id_info>
  <brief_title>Prospective Comparison Between TE, SWE and MRE (FULLFIBRO01)</brief_title>
  <acronym>FULLFIBRO01</acronym>
  <official_title>Prospective Comparison Between Transient Elastography (TE), Shear Wave Elastography (SWE) and Magnetic Resonance Elastography (MRE) for Non-invasive Assessment of Liver Fibrosis in Patients Affected by Chronic Viral Hepatitis</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Ente Ospedaliero Ospedali Galliera</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>General Electric</agency>
      <agency_class>Industry</agency_class>
    </collaborator>
  </sponsors>
  <source>Ente Ospedaliero Ospedali Galliera</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The main purpose of the present study is to compare the diagnostic performance of three&#xD;
      non-invasive stiffness imaging methods (TE, SWE and MRE) in a consecutive cohort of patients&#xD;
      with chronic viral C hepatitis or co-infected by HCV+ Human Human Immunodeficiency Virus&#xD;
      (HIV).&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Primary Endpoint: Verify if Transient Elastography, Shear Wave Elastography, Magnetic&#xD;
      Resonance Elastography (MRE) get comparable results in the measurement of liver fibrosis&#xD;
      Secondary Endpoint: To evaluate if the level of liver iron overload and steatosis may act as&#xD;
      a confounding factor in stiffness measurements by MRE.&#xD;
&#xD;
      Tertiary Endpoint: to provide information about the prevalence and grade of steatosis in a&#xD;
      consecutive cohort of patients with chronic viral C hepatitis, and to verify if the presence&#xD;
      and grade of parenchymal steatosis may affect the correlation between the different&#xD;
      non-invasive stiffness imaging modalities.&#xD;
&#xD;
      Subject: consecutive 100 patients affected by chronic viral C hepatitis or co-infected by&#xD;
      HCV+ Human Human Immunodeficiency Virus (HIV).&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">May 1, 2017</start_date>
  <completion_date type="Anticipated">November 1, 2018</completion_date>
  <primary_completion_date type="Anticipated">November 1, 2018</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>liver stiffness</measure>
    <time_frame>18 months</time_frame>
    <description>liver stiffness is indicated in kPa</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>liver iron overload</measure>
    <time_frame>18 months</time_frame>
    <description>liver iron concentration (LIC) is indicated in mg/g dw</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>liver steatosis</measure>
    <time_frame>18 months</time_frame>
    <description>liver steatosis</description>
  </secondary_outcome>
  <enrollment type="Anticipated">100</enrollment>
  <condition>Liver Fibrosis</condition>
  <eligibility>
    <study_pop>
      <textblock>
        patients affected by chronic C virus hepatitis (HCV) or co-infected by HCV+ Human&#xD;
        Immunodeficiency Virus (HIV)&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  enrollment of a consecutive cohort of at least 100 patients affected by chronic C&#xD;
             virus hepatitis (HCV) or co-infected by HCV+ Human Immunodeficiency Virus (HIV).&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  contraindications to undergo MRI examination. Impossibility to obtain a valid TE&#xD;
             measurement (e.g. narrow intercostal spaces; obese patients)&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>90 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Gian Andrea Rollandi, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Direttore SC Radiodiagnostica, Coordinatore Scientifico EO Ospedali Galliera Genova-Italy</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Gian Andrea Rollandi, MD</last_name>
    <phone>0039010563</phone>
    <phone_ext>4810</phone_ext>
    <email>gianandrea.rollandi@galliera.it</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Alessandra Argusti, PhD</last_name>
    <phone>0039010563</phone>
    <phone_ext>4188</phone_ext>
    <email>alessandra.argusti@galliera.it</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>SC Radiodiagnostica</name>
      <address>
        <city>Genova</city>
        <zip>16128</zip>
        <country>Italy</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Gian Andrea Rollandi, MD</last_name>
      <phone>0039010563</phone>
      <phone_ext>4810</phone_ext>
      <email>gianandrea.rollandi@galliera.it</email>
    </contact>
    <contact_backup>
      <last_name>Alessandra Argusti, PhD</last_name>
      <phone>0039010563</phone>
      <phone_ext>4188</phone_ext>
      <email>alessandra.argusti@galliera.it</email>
    </contact_backup>
  </location>
  <location_countries>
    <country>Italy</country>
  </location_countries>
  <reference>
    <citation>Ghany MG, Strader DB, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009 Apr;49(4):1335-74. doi: 10.1002/hep.22759. No abstract available.</citation>
    <PMID>19330875</PMID>
  </reference>
  <reference>
    <citation>Castera L. Invasive and non-invasive methods for the assessment of fibrosis and disease progression in chronic liver disease. Best Pract Res Clin Gastroenterol. 2011 Apr;25(2):291-303. doi: 10.1016/j.bpg.2011.02.003.</citation>
    <PMID>21497746</PMID>
  </reference>
  <reference>
    <citation>Bravo AA, Sheth SG, Chopra S. Liver biopsy. N Engl J Med. 2001 Feb 15;344(7):495-500. doi: 10.1056/NEJM200102153440706. No abstract available.</citation>
    <PMID>11172192</PMID>
  </reference>
  <reference>
    <citation>Regev A, Berho M, Jeffers LJ, Milikowski C, Molina EG, Pyrsopoulos NT, Feng ZZ, Reddy KR, Schiff ER. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol. 2002 Oct;97(10):2614-8. doi: 10.1111/j.1572-0241.2002.06038.x.</citation>
    <PMID>12385448</PMID>
  </reference>
  <reference>
    <citation>Baranova A, Lal P, Birerdinc A, Younossi ZM. Non-invasive markers for hepatic fibrosis. BMC Gastroenterol. 2011 Aug 17;11:91. doi: 10.1186/1471-230X-11-91.</citation>
    <PMID>21849046</PMID>
  </reference>
  <reference>
    <citation>Paparo F, Corradi F, Cevasco L, Revelli M, Marziano A, Molini L, Cenderello G, Cassola G, Rollandi GA. Real-time elastography in the assessment of liver fibrosis: a review of qualitative and semi-quantitative methods for elastogram analysis. Ultrasound Med Biol. 2014 Sep;40(9):1923-33. doi: 10.1016/j.ultrasmedbio.2014.03.021. Epub 2014 Jun 25.</citation>
    <PMID>24972497</PMID>
  </reference>
  <reference>
    <citation>Tang A, Cloutier G, Szeverenyi NM, Sirlin CB. Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 1, Principles and Techniques. AJR Am J Roentgenol. 2015 Jul;205(1):22-32. doi: 10.2214/AJR.15.14552. Epub 2015 Apr 23.</citation>
    <PMID>25905647</PMID>
  </reference>
  <reference>
    <citation>Ferraioli G, Tinelli C, Lissandrin R, Zicchetti M, Dal Bello B, Filice G, Filice C. Point shear wave elastography method for assessing liver stiffness. World J Gastroenterol. 2014 Apr 28;20(16):4787-96. doi: 10.3748/wjg.v20.i16.4787.</citation>
    <PMID>24782633</PMID>
  </reference>
  <reference>
    <citation>European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol. 2011 Aug;55(2):245-64. doi: 10.1016/j.jhep.2011.02.023. Epub 2011 Mar 1. No abstract available.</citation>
    <PMID>21371579</PMID>
  </reference>
  <reference>
    <citation>Tang A, Cloutier G, Szeverenyi NM, Sirlin CB. Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 2, Diagnostic Performance, Confounders, and Future Directions. AJR Am J Roentgenol. 2015 Jul;205(1):33-40. doi: 10.2214/AJR.15.14553. Epub 2015 Apr 23.</citation>
    <PMID>25905762</PMID>
  </reference>
  <reference>
    <citation>Ziol M, Handra-Luca A, Kettaneh A, Christidis C, Mal F, Kazemi F, de Ledinghen V, Marcellin P, Dhumeaux D, Trinchet JC, Beaugrand M. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology. 2005 Jan;41(1):48-54. doi: 10.1002/hep.20506.</citation>
    <PMID>15690481</PMID>
  </reference>
  <reference>
    <citation>Yoon JH, Lee JM, Joo I, Lee ES, Sohn JY, Jang SK, Lee KB, Han JK, Choi BI. Hepatic fibrosis: prospective comparison of MR elastography and US shear-wave elastography for evaluation. Radiology. 2014 Dec;273(3):772-82. doi: 10.1148/radiol.14132000. Epub 2014 Jul 7.</citation>
    <PMID>25007047</PMID>
  </reference>
  <reference>
    <citation>Bohte AE, de Niet A, Jansen L, Bipat S, Nederveen AJ, Verheij J, Terpstra V, Sinkus R, van Nieuwkerk KM, de Knegt RJ, Baak BC, Jansen PL, Reesink HW, Stoker J. Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C. Eur Radiol. 2014 Mar;24(3):638-48. doi: 10.1007/s00330-013-3046-0. Epub 2013 Oct 25.</citation>
    <PMID>24158528</PMID>
  </reference>
  <reference>
    <citation>Paparo F, Cenderello G, Revelli M, Bacigalupo L, Rutigliani M, Zefiro D, Cevasco L, Amico M, Bandelloni R, Cassola G, Forni GL, Rollandi GA. Diagnostic value of MRI proton density fat fraction for assessing liver steatosis in chronic viral C hepatitis. Biomed Res Int. 2015;2015:758164. doi: 10.1155/2015/758164. Epub 2015 Mar 19.</citation>
    <PMID>25866807</PMID>
  </reference>
  <reference>
    <citation>Negro F. Mechanisms and significance of liver steatosis in hepatitis C virus infection. World J Gastroenterol. 2006 Nov 14;12(42):6756-65. doi: 10.3748/wjg.v12.i42.6756.</citation>
    <PMID>17106922</PMID>
  </reference>
  <reference>
    <citation>Sun HY, Lee JM, Han JK, Choi BI. Usefulness of MR elastography for predicting esophageal varices in cirrhotic patients. J Magn Reson Imaging. 2014 Mar;39(3):559-66. doi: 10.1002/jmri.24186. Epub 2013 Sep 23.</citation>
    <PMID>24115368</PMID>
  </reference>
  <reference>
    <citation>Manduca A, Oliphant TE, Dresner MA, Mahowald JL, Kruse SA, Amromin E, Felmlee JP, Greenleaf JF, Ehman RL. Magnetic resonance elastography: non-invasive mapping of tissue elasticity. Med Image Anal. 2001 Dec;5(4):237-54. doi: 10.1016/s1361-8415(00)00039-6.</citation>
    <PMID>11731304</PMID>
  </reference>
  <reference>
    <citation>Bydder M, Yokoo T, Hamilton G, Middleton MS, Chavez AD, Schwimmer JB, Lavine JE, Sirlin CB. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging. 2008 Apr;26(3):347-59. doi: 10.1016/j.mri.2007.08.012. Epub 2008 Feb 21.</citation>
    <PMID>18093781</PMID>
  </reference>
  <reference>
    <citation>Angelucci E, Giovagnoni A, Valeri G, Paci E, Ripalti M, Muretto P, McLaren C, Brittenham GM, Lucarelli G. Limitations of magnetic resonance imaging in measurement of hepatic iron. Blood. 1997 Dec 15;90(12):4736-42.</citation>
    <PMID>9389689</PMID>
  </reference>
  <reference>
    <citation>Paparo F, Cevasco L, Zefiro D, Biscaldi E, Bacigalupo L, Balocco M, Pongiglione M, Banderali S, Forni GL, Rollandi GA. Diagnostic value of real-time elastography in the assessment of hepatic fibrosis in patients with liver iron overload. Eur J Radiol. 2013 Dec;82(12):e755-61. doi: 10.1016/j.ejrad.2013.08.038. Epub 2013 Aug 30.</citation>
    <PMID>24050879</PMID>
  </reference>
  <verification_date>September 2017</verification_date>
  <study_first_submitted>September 21, 2017</study_first_submitted>
  <study_first_submitted_qc>September 21, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">September 26, 2017</study_first_posted>
  <last_update_submitted>September 21, 2017</last_update_submitted>
  <last_update_submitted_qc>September 21, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">September 26, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Ente Ospedaliero Ospedali Galliera</investigator_affiliation>
    <investigator_full_name>Gian Andrea Rollandi</investigator_full_name>
    <investigator_title>Direttore medico responsabile S.C. Radiodiagnostica</investigator_title>
  </responsible_party>
  <keyword>HCV</keyword>
  <keyword>HIV</keyword>
  <keyword>Liver Fibrosis</keyword>
  <keyword>Liver Iron Overload</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Liver Cirrhosis</mesh_term>
    <mesh_term>Fibrosis</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03293953
org study id: 41UCS2016
nct id: NCT03293953
lead sponsor: 
collaborator: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
The main purpose of the present study is to compare the diagnostic performance of three
      non-invasive stiffness imaging methods (TE, SWE and MRE) in a consecutive cohort of patients
      with chronic viral C hepatitis or co-infected by HCV+ Human Human Immunodeficiency Virus
      (HIV).
Primary Endpoint: Verify if Transient Elastography, Shear Wave Elastography, Magnetic
      Resonance Elastography (MRE) get comparable results in the measurement of liver fibrosis
      Secondary Endpoint: To evaluate if the level of liver iron overload and steatosis may act as
      a confounding factor in stiffness measurements by MRE.

      Tertiary Endpoint: to provide information about the prevalence and grade of steatosis in a
      consecutive cohort of patients with chronic viral C hepatitis, and to verify if the presence
      and grade of parenchymal steatosis may affect the correlation between the different
      non-invasive stiffness imaging modalities.

      Subject: consecutive 100 patients affected by chronic viral C hepatitis or co-infected by
      HCV+ Human Human Immunodeficiency Virus (HIV).
observational model: Cohort
time perspective: Prospective
measure: liver stiffness
time frame: 18 months
description: liver stiffness is indicated in kPa
measure: liver iron overload
time frame: 18 months
description: liver iron concentration (LIC) is indicated in mg/g dw
measure: liver steatosis
time frame: 18 months
description: liver steatosis
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: 90 Years
healthy volunteers: No
last name: Gian Andrea Rollandi, MD
role: Principal Investigator
affiliation: Direttore SC Radiodiagnostica, Coordinatore Scientifico EO Ospedali Galliera Genova-Italy
last name: Gian Andrea Rollandi, MD
phone: 0039010563
phone ext: 4810
email: gianandrea.rollandi@galliera.it
last name: Alessandra Argusti, PhD
phone: 0039010563
phone ext: 4188
email: alessandra.argusti@galliera.it
facility: 
status: Recruiting
contact: 
contact backup: 
country: Italy
citation: Ghany MG, Strader DB, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009 Apr;49(4):1335-74. doi: 10.1002/hep.22759. No abstract available.
PMID: 19330875
citation: Castera L. Invasive and non-invasive methods for the assessment of fibrosis and disease progression in chronic liver disease. Best Pract Res Clin Gastroenterol. 2011 Apr;25(2):291-303. doi: 10.1016/j.bpg.2011.02.003.
PMID: 21497746
citation: Bravo AA, Sheth SG, Chopra S. Liver biopsy. N Engl J Med. 2001 Feb 15;344(7):495-500. doi: 10.1056/NEJM200102153440706. No abstract available.
PMID: 11172192
citation: Regev A, Berho M, Jeffers LJ, Milikowski C, Molina EG, Pyrsopoulos NT, Feng ZZ, Reddy KR, Schiff ER. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol. 2002 Oct;97(10):2614-8. doi: 10.1111/j.1572-0241.2002.06038.x.
PMID: 12385448
citation: Baranova A, Lal P, Birerdinc A, Younossi ZM. Non-invasive markers for hepatic fibrosis. BMC Gastroenterol. 2011 Aug 17;11:91. doi: 10.1186/1471-230X-11-91.
PMID: 21849046
citation: Paparo F, Corradi F, Cevasco L, Revelli M, Marziano A, Molini L, Cenderello G, Cassola G, Rollandi GA. Real-time elastography in the assessment of liver fibrosis: a review of qualitative and semi-quantitative methods for elastogram analysis. Ultrasound Med Biol. 2014 Sep;40(9):1923-33. doi: 10.1016/j.ultrasmedbio.2014.03.021. Epub 2014 Jun 25.
PMID: 24972497
citation: Tang A, Cloutier G, Szeverenyi NM, Sirlin CB. Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 1, Principles and Techniques. AJR Am J Roentgenol. 2015 Jul;205(1):22-32. doi: 10.2214/AJR.15.14552. Epub 2015 Apr 23.
PMID: 25905647
citation: Ferraioli G, Tinelli C, Lissandrin R, Zicchetti M, Dal Bello B, Filice G, Filice C. Point shear wave elastography method for assessing liver stiffness. World J Gastroenterol. 2014 Apr 28;20(16):4787-96. doi: 10.3748/wjg.v20.i16.4787.
PMID: 24782633
citation: European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol. 2011 Aug;55(2):245-64. doi: 10.1016/j.jhep.2011.02.023. Epub 2011 Mar 1. No abstract available.
PMID: 21371579
citation: Tang A, Cloutier G, Szeverenyi NM, Sirlin CB. Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 2, Diagnostic Performance, Confounders, and Future Directions. AJR Am J Roentgenol. 2015 Jul;205(1):33-40. doi: 10.2214/AJR.15.14553. Epub 2015 Apr 23.
PMID: 25905762
citation: Ziol M, Handra-Luca A, Kettaneh A, Christidis C, Mal F, Kazemi F, de Ledinghen V, Marcellin P, Dhumeaux D, Trinchet JC, Beaugrand M. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology. 2005 Jan;41(1):48-54. doi: 10.1002/hep.20506.
PMID: 15690481
citation: Yoon JH, Lee JM, Joo I, Lee ES, Sohn JY, Jang SK, Lee KB, Han JK, Choi BI. Hepatic fibrosis: prospective comparison of MR elastography and US shear-wave elastography for evaluation. Radiology. 2014 Dec;273(3):772-82. doi: 10.1148/radiol.14132000. Epub 2014 Jul 7.
PMID: 25007047
citation: Bohte AE, de Niet A, Jansen L, Bipat S, Nederveen AJ, Verheij J, Terpstra V, Sinkus R, van Nieuwkerk KM, de Knegt RJ, Baak BC, Jansen PL, Reesink HW, Stoker J. Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C. Eur Radiol. 2014 Mar;24(3):638-48. doi: 10.1007/s00330-013-3046-0. Epub 2013 Oct 25.
PMID: 24158528
citation: Paparo F, Cenderello G, Revelli M, Bacigalupo L, Rutigliani M, Zefiro D, Cevasco L, Amico M, Bandelloni R, Cassola G, Forni GL, Rollandi GA. Diagnostic value of MRI proton density fat fraction for assessing liver steatosis in chronic viral C hepatitis. Biomed Res Int. 2015;2015:758164. doi: 10.1155/2015/758164. Epub 2015 Mar 19.
PMID: 25866807
citation: Negro F. Mechanisms and significance of liver steatosis in hepatitis C virus infection. World J Gastroenterol. 2006 Nov 14;12(42):6756-65. doi: 10.3748/wjg.v12.i42.6756.
PMID: 17106922
citation: Sun HY, Lee JM, Han JK, Choi BI. Usefulness of MR elastography for predicting esophageal varices in cirrhotic patients. J Magn Reson Imaging. 2014 Mar;39(3):559-66. doi: 10.1002/jmri.24186. Epub 2013 Sep 23.
PMID: 24115368
citation: Manduca A, Oliphant TE, Dresner MA, Mahowald JL, Kruse SA, Amromin E, Felmlee JP, Greenleaf JF, Ehman RL. Magnetic resonance elastography: non-invasive mapping of tissue elasticity. Med Image Anal. 2001 Dec;5(4):237-54. doi: 10.1016/s1361-8415(00)00039-6.
PMID: 11731304
citation: Bydder M, Yokoo T, Hamilton G, Middleton MS, Chavez AD, Schwimmer JB, Lavine JE, Sirlin CB. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging. 2008 Apr;26(3):347-59. doi: 10.1016/j.mri.2007.08.012. Epub 2008 Feb 21.
PMID: 18093781
citation: Angelucci E, Giovagnoni A, Valeri G, Paci E, Ripalti M, Muretto P, McLaren C, Brittenham GM, Lucarelli G. Limitations of magnetic resonance imaging in measurement of hepatic iron. Blood. 1997 Dec 15;90(12):4736-42.
PMID: 9389689
citation: Paparo F, Cevasco L, Zefiro D, Biscaldi E, Bacigalupo L, Balocco M, Pongiglione M, Banderali S, Forni GL, Rollandi GA. Diagnostic value of real-time elastography in the assessment of hepatic fibrosis in patients with liver iron overload. Eur J Radiol. 2013 Dec;82(12):e755-61. doi: 10.1016/j.ejrad.2013.08.038. Epub 2013 Aug 30.
PMID: 24050879
responsible party type: Principal Investigator
investigator affiliation: Ente Ospedaliero Ospedali Galliera
investigator full name: Gian Andrea Rollandi
investigator title: Direttore medico responsabile S.C. Radiodiagnostica
mesh term: Liver Cirrhosis
mesh term: Fibrosis
sharing ipd: Undecided