<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03240640</url>
  </required_header>
  <id_info>
    <org_study_id>S58513</org_study_id>
    <nct_id>NCT03240640</nct_id>
  </id_info>
  <brief_title>Effects of Inspiratory Muscle Training on Shortness of Breath (Dyspnea) and Postural Control in Patients With COPD</brief_title>
  <official_title>Effects of Inspiratory Muscle Training on Shortness of Breath (Dyspnea) and Postural Control in Patients With COPD</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>KU Leuven</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>KU Leuven</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Shortness of breath (dyspnea) is an important symptom during physical exertion in patients&#xD;
      with chronic obstructive pulmonary disease (COPD) and is related to respiratory muscle&#xD;
      weakness. Dyspnea is a multidimensional sensation. The sensory perceptual domain (perceived&#xD;
      dyspnea intensity) has been study extensively. The perception of respiratory distress&#xD;
      (unpleasantness of dyspnea) has not received as much attention. Inspiratory muscle training&#xD;
      (IMT) has been shown to improve inspiratory muscle function and reduce dyspnea intensity.&#xD;
      Balance impairments increasing the risk of falling is another recognized problem in patients&#xD;
      with COPD. Postural balance has been shown to be especially impaired in patients with COPD&#xD;
      who have pronounced respiratory muscle weakness. Improvements in respiratory muscle function&#xD;
      might improve balance control in patients. Respiratory Muscle Metaboreflex is known as&#xD;
      respiratory muscle work during exercise reflexively induces sympathetically mediated&#xD;
      vasoconstrictor activity, there by compromising blood flow and oxygen delivery to active limb&#xD;
      and respiratory muscles.&#xD;
&#xD;
      Eight weeks of controlled IMT is hypothesized to reduce both intensity as well as&#xD;
      unpleasntness domain of dyspnea perception, improve postural control and improves blood flow&#xD;
      and oxygen delivery to limb muscles in patients with COPD who have pronounced respiratory&#xD;
      muscle weakness.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The purpose of this clinical trial is to elucidate mechanisms of dyspnea relief and&#xD;
      improvements in postural control after inspiratory muscle training (IMT) in patients with&#xD;
      COPD.&#xD;
&#xD;
      An endurance cycle exercise test (Constant work rate (CWR) test) will be used to evaluate&#xD;
      dyspnea intensity and unpleasantness at comparable breathing efforts, at comparable work&#xD;
      rates on the cycle ergometer, before and after IMT. Patients will be performing a CWR test at&#xD;
      75% of the peak work rate achieved during a maximal incremental cardiopulmonary exercise test&#xD;
      (CPET). Before, during and after CWR cycling tests patients will rate their intensity of&#xD;
      dyspnea, unpleasantness of dyspnea, breathing related-anxiety and leg discomfort using a&#xD;
      modified 10- point Borg scale. Patients will be asked to report qualitative descriptors of&#xD;
      dyspnea at the end of the CWR cycling test. Maximum duration of the CWR test will be recorded&#xD;
      and levels of minute ventilation will be registered continuously throughout the exercise&#xD;
      protocol. With this endurance exercise test the investigators will be able to assess changes&#xD;
      in the onset of dyspnea (intensity and unpleasantness) and the performance in endurance&#xD;
      exercise before and after IMT.&#xD;
&#xD;
      Surface electromyography (EMG), and a multipair esophageal electrode catheter system will be&#xD;
      used during CWR exercise to evaluate respiratory muscle recruitment, respiratory effort and&#xD;
      neural drive to the different respiratory muscles. The catheter will be inserted to&#xD;
      continuously record Pes (esophageal pressure), Pgas (gastric pressure) and EMGdi&#xD;
      (electromyogram of the diaphragm muscle). PesMax (maximal esophageal pressure), PgasMax&#xD;
      (maximal gastric pressure) and PdiMax (maximal transdiaphragmatic pressure) will be obtained&#xD;
      during maximal sniff and cough maneuvers. Transcutaneous surface electromyography (sEMG)&#xD;
      techniques will be applied to scalene, sternocleidomastoid and parasternal intercostal&#xD;
      muscles to register neural drive to these respiratory muscles. With this measurements, the&#xD;
      investigators will be able to assess whether there are any changes in respiratory muscle&#xD;
      recruitment patterns and respiratory neural drive to the different respiratory muscles after&#xD;
      IMT.&#xD;
&#xD;
      During exercise 'Respiratory Muscle Metaboreflex' will lead to sympathetically mediated&#xD;
      vasoconstriction of limb locomotor muscle, less blood and oxygen supply to active limbs&#xD;
      muscle there by locomotor muscle fatigue occurred. Quadriceps twitch forces evoked by&#xD;
      magnetic stimulation of femoral nerve will be assessed to measure locomotor muscle fatigue at&#xD;
      identical exercise time points during CWR test before and after the intervention. With this&#xD;
      technique, the investigators will be able to assess whether the onset of locomotor muscle&#xD;
      fatigue is delayed after IMT.&#xD;
&#xD;
      An isocapnic hyperpnea trial will be performed to assess respiratory muscle perfusion,&#xD;
      dyspnea intensity and unpleasantness, respiratory muscle recruitment pattern, respiratory&#xD;
      effort and neural respiratory drive without the work of locomotor muscle before and after&#xD;
      IMT. Patients will be asked to maintain a targeted minute ventilation pattern equal to their&#xD;
      breathing frequency, tidal volume and minute ventilation recorded at rest and during the&#xD;
      final minute of constant load exercise test (at ~75% WRpeak). Experimenters will provide&#xD;
      verbal guidance to patients to adjust the rate and depth of their breathing such that the&#xD;
      target ventilation will be obtained and maintained constant within ±5%. Isocapnia will be&#xD;
      maintained by having subjects inspire from a Douglas bag containing 5% CO2, 21% O2, balance&#xD;
      N2 that will be connected to a two-way non-rebreathing valve (model 2700, Hans Rudolph) by a&#xD;
      piece of tubing.&#xD;
&#xD;
      Loaded breathing tests will be performed to assess dyspnea intensity and unpleasantness,&#xD;
      respiratory muscle recruitment patterns, respiratory effort and neural respiratory drive.&#xD;
      Patients will be asked to breathe through a tapered flow resistive loading (TFRL) device&#xD;
      (powerbreathe KH1) as long as they can (3-7 minutes), the resistance will be set at 50% of&#xD;
      patients' PImax. Heart rate, oxygen saturation, and number of breaths will be monitored.&#xD;
      Before and after the test Borg dyspnea, inspiratory effort and unpleasantness will be&#xD;
      recorded. The test will be repeated after 8 weeks of IMT, at the same resistance. Borg&#xD;
      dyspnea, inspiratory effort and unpleasantness will be recorded at time limit of pre-training&#xD;
      and at the symptom limit. The longest time for post training can be up to 15 minutes.&#xD;
&#xD;
      Respiratory (i.e., intercostal, scalene and abdominal) and locomotor muscle blood flow index&#xD;
      (i.e., vastus lateralis) will be simultaneously measured during isocapnic hyperpnea trials as&#xD;
      well as during CWR test (at 75% of the peak work rate) before and after IMT according to a&#xD;
      previously established method using Near-Infrared Spectroscopy (NIRS) and indocyanine green&#xD;
      (ICG). Respiratory (i.e., intercostal, scalene, abdominal) and locomotor muscle (i.e., vastus&#xD;
      lateralis) oxygen delivery will be calculated by multiplying blood flow index to arterial&#xD;
      oxygen content, the latter will be calculated non-invasively by pulse oximetry. Respiratory&#xD;
      (i.e., intercostal, scalene, abdominal) and locomotor muscle (i.e., vastus lateralis) oxygen&#xD;
      saturation (Stio2) - an index of oxygen availability reflecting the balance between oxygen&#xD;
      supply and demand-, will be recorded continuously during the trial by NIRS.&#xD;
&#xD;
      A noninvasive technique for studying the neural processing of respiratory sensations will be&#xD;
      used to assess changes in the affective unpleasantness component of dyspnea during a&#xD;
      standardized loaded breathing task. Electroencephalography (EEG) will be used to measure&#xD;
      respiratory related evoked potentials (RREPs) during loaded and unloaded breathing. The RREP&#xD;
      recorded from EEG is a measurement of cerebral cortical activity, which is elicited by the&#xD;
      activation of lung and muscle mechanoreceptors due to short inspiratory occlusions. Patients&#xD;
      will be wearing EEG sensors [129 channel system, Electrical Geodesics Inc., Eugene, USA] and&#xD;
      breathe through a breathing circuit with a non-rebreathing valve via a mouthpiece. The&#xD;
      inspiration will be interrupted briefly for 150 milliseconds every two to six breaths by&#xD;
      activation of the occlusion valve with pressurized air, which induces the RREP. Patients will&#xD;
      be rating their perceived intensity and unpleasantness of dyspnea and intensity of occlusion&#xD;
      on a Borg scale while inspiratory load and occlusion will be applied via a breathing valve.&#xD;
      This method will be used to assess if there is less unpleasantness associated with a giving&#xD;
      level of dyspnea elicited by a resistive breathing task and whether these changes are&#xD;
      correlated with changes in the central processing of the dyspnea sensation.&#xD;
&#xD;
      To evaluate postural balance, displacement of the center of pressure (CoP) in will be&#xD;
      estimated from the raw force plate data using the equation: CoP = Mx/Fz (medio-lateral) and&#xD;
      CoP=My/Fz (anterior-posterior). CoP will be measured during upright standing with and without&#xD;
      vision, on stable and unstable (foam pad) support surface. During some conditions, local&#xD;
      muscle vibration on ankle and/or back muscles will be applied to evaluate the role of&#xD;
      proprioception in postural control. Furthermore, in some conditions a repetitive ballistic&#xD;
      arm movement will be asked to evaluate the effect of a internal perturbation on postural&#xD;
      control. Root mean square values of the CoP displacements will be used for the analysis of&#xD;
      postural stability measures and mean values will be calculated for the vibration trials to&#xD;
      analyze the expected directional effect. A ratio of the CoP displacements of the ankle&#xD;
      muscles vibration trial regard to the back muscles vibration trial will be calculated to&#xD;
      determine the proprioceptive postural control strategy.&#xD;
&#xD;
      A sample size of 16 participants for intervention group and 8 for control group are required&#xD;
      to detect a difference of one unit in dyspnea Borg-10 scale, assuming a SD of 1 unit in the&#xD;
      change in dyspnea score between pre and post measurements (power 80%, level of significance&#xD;
      p&lt;0.05). These estimates are based on previous work on dyspnea during exercise. Therefore 24&#xD;
      clinically stable COPD patients with inspiratory muscle weakness (PiMax&lt;70% predicted or&#xD;
      &lt;60cmH2O) and dyspnea symptoms (BDI&lt;7) will be included. Patients who are unable to perform&#xD;
      exercise testing will be excluded.&#xD;
&#xD;
      Patients will perform daily training consisting of two training sessions of 30 breaths&#xD;
      (intensity ~50% of PiMax; 4-5 minutes per session). One session per week will be performed&#xD;
      supervised at the research center. IMT will be performed using an electronic tapered flow&#xD;
      resistive loading (TFRL) device [POWERbreath®KH1, HaB International Ltd., Southam, UK] for 8&#xD;
      weeks. The PiMax will be measured every week in order to increase the appropriate training&#xD;
      intensity to around 50% of the PiMax at that moment. The sham group will perform IMT at an&#xD;
      inspiratory load that is not expected to improve inspiratory muscle function (intensity &lt;10%&#xD;
      of baseline PiMax; unchanged throughout the protocol).&#xD;
&#xD;
      Differences in primary and secondary outcomes between groups after 8 weeks of IMT will be&#xD;
      compared adjusting for baseline differences in an analysis of covariance (ANCOVA).&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">February 1, 2017</start_date>
  <completion_date type="Actual">January 31, 2022</completion_date>
  <primary_completion_date type="Actual">November 30, 2021</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Dyspnea (Borg CR-10 scale)</measure>
    <time_frame>Change from Baseline in Borg CR-10 scale at 8 weeks</time_frame>
    <description>Dyspnea intensity perception on a 10-point Borg scale during constant work rate cycling exercise.&#xD;
Numerical value reported for intensity of dyspnea (shortness of breath) ranging from 0 (no symptoms) to 10 (maximal symptoms)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Center of pressure displacement</measure>
    <time_frame>Change from Baseline in center of pressure at 8 weeks</time_frame>
    <description>Difference in center of pressure displacement on unstable support surface during a balance task after the intervention</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Maximal inspiratory pressure (Pi,max)</measure>
    <time_frame>Change from Baseline in Pi,max at 8 weeks</time_frame>
    <description>Maximal voluntary inspiratory pressure will be recorded at the mouth to assess inspiratory muscle strength (pressure generating capacity). Measurements will be performed at functional residual capacity for inspiratory respiratory pressure (maximal inspiratory pressure; Pi,max ) using the technique proposed by Black and Hyatt. (Black LF, Hyatt RE. Maximal respiratory pressures: normal values and relationship to age and sex. Am Rev Respir Dis 1969;99:696-702.) An electronic pressure transducer will be used (MicroRPM; Micromedical, Kent, UK) to register pressures. Reference values published by Rochester and Arora will be used to define percentages of normal respiratory muscle pressures. (Rochester DF, Arora NS. Respiratory muscle failure. Med Clin North Am 1983;67:573-97.)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Inspiratory Muscle Endurance during a constant load breathing task</measure>
    <time_frame>Change from Baseline in endurance time at 8 weeks</time_frame>
    <description>To measure inspiratory muscle endurance patients will be asked to breathe against a submaximal inspiratory load provided by a flow resistive loading device (POWERbreathe®KH1, HaB International Ltd., Southam, UK) until task failure. An inspiratory load will be selected that allows patients to continue breathing against the resistance for 3-7 minutes (typically between 50-60% of the Pi,max). Breathing instructions for patients will be the same as during the training sessions. Number of breaths, average duty cycle (inspiratory time as a fraction of the total respiratory cycle), average load, average power, and total work will be registered during the test by the handheld loading device. After 8 weeks of IMT the test will be repeated against an identical load and improvements in endurance time (seconds) will be registered as the main outcome. Changes in breathing parameters will be also registered.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Endurance capacity during a constant load cycling exercise test</measure>
    <time_frame>Change from Baseline in endurance cycling time at 8 weeks</time_frame>
    <description>A constant work rate (CWR) cycling test will be perform at 75% of the peak work rate achieved during a maximal incremental cardiopulmonary exercise test (CPET). Time (minute) till symptom limit during a CWR cycling will be measured.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Respiratory effort</measure>
    <time_frame>Change from Baseline in respiratory effort at 8 weeks</time_frame>
    <description>Pes-Esophageal Pressure (cmH2O) and Pgas-Gastric Pressure (cmH20) will be recorded continuously using a multipair esophageal electrode catheter system to assess respiratory effort (Pi/Pi,max). Maximal sniff and cough maneuvers will be performed to obtain Pes,max, Pgas,max, and Pdi,max values. Pdi -Transdiaphragmatic Pressure (cmH2O) will be calculated by subtraction of Pes from Pga.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Neural Respiratory Drive</measure>
    <time_frame>Change from Baseline in Neural Respiratory Drive at 8 weeks</time_frame>
    <description>Measuring neural output in term of activation of respiratory muscles using a multipair esophageal electrode catheter system. EMGdi-Diaphragm electromyogram (volt), sEMG-Transcutaneous electromyography (volt) of the scalene and intercostal muscles will be derived by using technique described by Duiverman et al. The result will be presented in the percentage of maximum activation of each respiratory muscle (%EMGmax)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Ventilatory Muscle Recruitment (VMR)</measure>
    <time_frame>Change from Baseline in Ventilatory Muscle Recruitment at 8 weeks</time_frame>
    <description>The ventilatory muscle recruitment (VMR) will be determined as the slope of the line between points of zero flow at end-expiration and end-inspiration for the Pga-Pes Plots; Increasing contribution of the diaphragm is represented by more negative slopes, while less negative slopes represent increasing contribution of inspiratory.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Respiratory and locomotor muscle perfusion</measure>
    <time_frame>Change from Baseline in respiratory and locomotor muscle blood flow at 8 weeks</time_frame>
    <description>Near infrared spectroscopy (NIRS) in combination with indocyanine green tracer (ICG) (NIRS-ICG method) will be used to simultaneously assess blood flow index (BFI) in both respiratory and locomotor muscle. Specifically, for the respiratory muscles BFI will be measured by recording the tissue ICG concentration over time (i.e., ICG concentration curve) by NIRS and will be expressed in nM/s (nanomoles per second) units. The same procedure will be applied for the locomotor muscle and BFI will also expressed as nM/s (nanomoles per second) units.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Locomotor muscle fatigue (Quadriceps twitch forces)</measure>
    <time_frame>Change from Baseline in quadriceps twitch forces at 8 weeks</time_frame>
    <description>Quadriceps twitch forces will be measured using transcutaneous magnetic twitch stimulation of the femoral nerve. Comparing the quadriceps twitch forces before and after exercise is a representation of locomotors muscle fatigue.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pulmonary Function</measure>
    <time_frame>Change from Baseline in Pulmonary Function parameters at 8 weeks</time_frame>
    <description>Pulmonary function Spirometry and whole body plethysmography will be performed according to the European Respiratory Society guidelines for pulmonary function testing (Vmax Autobox, Sensor Medics, Bilthoven, the Netherlands). (Quanjer PH, Tammeling GJ, Cotes JE, et al. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993;16:5-40.) Changes in FEV1 (L), FVC (L), FRC (L), RV (L), IC (L) and peak inspiratory flow (L/s) will be registered.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Daily Physical Activity</measure>
    <time_frame>Change in daily steps and time in moderate to vigorous daily physical activity from Baseline at 8 weeks</time_frame>
    <description>Assessed with the Actigraph and Dynaport MoveMonitor monitor. Step per day (steps) and time (hours) of moderate to vigorous daily physical activity will be measured.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Dyspnea intensity (Borg CR-10 scale)</measure>
    <time_frame>Change from Baseline in Borg CR-10 scale at 8 weeks</time_frame>
    <description>Rating of dyspnea intensity (Borg CR-10 scale) during standardized loaded breathing tasks with occlusion events.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Dyspnea unpleasantness (Borg CR-10 scale)</measure>
    <time_frame>Change from Baseline in Borg CR-10 scale at 8 weeks</time_frame>
    <description>Rating of dyspnea unpleasantness (Borg CR-10 scale) during standardized loaded breathing tasks with occlusion events.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Respiratory-related evoked potential (RREPs)</measure>
    <time_frame>Change from Baseline in RREPs at 8 weeks</time_frame>
    <description>Respiratory-related evoked potential (RREPs) measured by means of EEG during condition of resistive load induced dyspnea and unloaded breathing.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Evoked potential elicited by the geometric figures</measure>
    <time_frame>Change from Baseline in Evoked potential at 8 weeks</time_frame>
    <description>Evoked potential elicited by the geometric figures during baseline and dyspnea condition</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Stress level</measure>
    <time_frame>Change from Baseline in stress level at 8 weeks</time_frame>
    <description>Stress level before, during and after test intermittent dyspnea challenges will be measured using distress thermometer, rating on the scale 1 to 10.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Salivary cortisol levels</measure>
    <time_frame>Change from Baseline in salivary cortisol levels at 8 weeks</time_frame>
    <description>Salivary cortisol levels (nmol/l) before, during and after test intermittent dyspnea challenges was collected. The level between &gt;7 and &lt;17 nmol/l considers standard cortisol levels.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">18</enrollment>
  <condition>Copd</condition>
  <condition>Inspiratory Muscle Weakness</condition>
  <arm_group>
    <arm_group_label>Inspiratory Muscle Strength Training</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>High intensity inspiratory muscle training</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Inspiratory Muscle Endurance Training</arm_group_label>
    <arm_group_type>Sham Comparator</arm_group_type>
    <description>Sham inspiratory muscle training at low intensity</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Inspiratory Muscle Strength Training</intervention_name>
    <description>IMT will be performed using a variable flow resistive loading device (POWERbreathe®KH1, HaB International Ltd., Southam, UK). The device is able to store training parameters of up to 40 sessions. Most training sessions during this RCT will be performed by patients at their homes without supervision. The intervention group (strength IMT) will perform two daily sessions of 30 breaths. Measurements of Pi,max will be performed every week and training loads will be increased continuously to maintain at least 40-50% of the actual Pi,max values. Each week, one training session will be performed under supervision. Training load will be increased during this session.</description>
    <arm_group_label>Inspiratory Muscle Strength Training</arm_group_label>
    <other_name>Electronic Variable Flow Resistive Loading IMT Device</other_name>
    <other_name>POWERbreathe®KH1, HaB International Ltd., Southam, UK</other_name>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Inspiratory Muscle Endurance Training</intervention_name>
    <description>IMT will be performed using a variable flow resistive loading device (POWERbreathe®KH1, HaB International Ltd., Southam, UK). The device is able to store training parameters of up to 40 sessions. Most training sessions during this RCT will be performed by patients at their homes without supervision. The sham group (endurance IMT) will perform three daily sessions of 30 breaths and will train at a constant inspiratory load of no more than 10% of their initial Pi,max. Each week, one training session will be performed under supervision.</description>
    <arm_group_label>Inspiratory Muscle Endurance Training</arm_group_label>
    <other_name>Electronic Variable Flow Resistive Loading IMT Device</other_name>
    <other_name>POWERbreathe®KH1, HaB International Ltd., Southam, UK</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Clinical Diagnosis of COPD&#xD;
&#xD;
          -  Inspiratory Muscle Weakness (Pi,max &lt;70% predicted or &lt; 60 cmH2O)&#xD;
&#xD;
          -  Baseline dyspnea index (BDI) &lt; 7&#xD;
&#xD;
          -  Peripheral muscle fatigue present after CPET&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Major cardiovascular&#xD;
&#xD;
          -  Limiting exercise capacity more than pulmonary function impairment&#xD;
&#xD;
          -  Severe orthopedic with major impact on daily activities&#xD;
&#xD;
          -  Psychiatric or cognitive disorders&#xD;
&#xD;
          -  Progressive neurological or neuromuscular disorders&#xD;
&#xD;
          -  Longterm O2 therapy&#xD;
&#xD;
          -  Previous inclusion in rehabilitation program (&lt;1 year)&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>40 Years</minimum_age>
    <maximum_age>90 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Rik Gosselink, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Vicerector of Student Affairs KU Leuven</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>University Hospital Leuven</name>
      <address>
        <city>Leuven</city>
        <zip>3000</zip>
        <country>Belgium</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Belgium</country>
  </location_countries>
  <verification_date>February 2023</verification_date>
  <study_first_submitted>January 26, 2017</study_first_submitted>
  <study_first_submitted_qc>August 2, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">August 7, 2017</study_first_posted>
  <last_update_submitted>February 7, 2023</last_update_submitted>
  <last_update_submitted_qc>February 7, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">February 8, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>KU Leuven</investigator_affiliation>
    <investigator_full_name>Daniel Langer</investigator_full_name>
    <investigator_title>Principal Investigator</investigator_title>
  </responsible_party>
  <keyword>Inspiratory muscle training</keyword>
  <keyword>COPD</keyword>
  <keyword>Dyspnea</keyword>
  <keyword>Balance</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Muscle Weakness</mesh_term>
    <mesh_term>Dyspnea</mesh_term>
    <mesh_term>Respiratory Aspiration</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03240640
org study id: S58513
nct id: NCT03240640
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
Shortness of breath (dyspnea) is an important symptom during physical exertion in patients
      with chronic obstructive pulmonary disease (COPD) and is related to respiratory muscle
      weakness. Dyspnea is a multidimensional sensation. The sensory perceptual domain (perceived
      dyspnea intensity) has been study extensively. The perception of respiratory distress
      (unpleasantness of dyspnea) has not received as much attention. Inspiratory muscle training
      (IMT) has been shown to improve inspiratory muscle function and reduce dyspnea intensity.
      Balance impairments increasing the risk of falling is another recognized problem in patients
      with COPD. Postural balance has been shown to be especially impaired in patients with COPD
      who have pronounced respiratory muscle weakness. Improvements in respiratory muscle function
      might improve balance control in patients. Respiratory Muscle Metaboreflex is known as
      respiratory muscle work during exercise reflexively induces sympathetically mediated
      vasoconstrictor activity, there by compromising blood flow and oxygen delivery to active limb
      and respiratory muscles.

      Eight weeks of controlled IMT is hypothesized to reduce both intensity as well as
      unpleasntness domain of dyspnea perception, improve postural control and improves blood flow
      and oxygen delivery to limb muscles in patients with COPD who have pronounced respiratory
      muscle weakness.
The purpose of this clinical trial is to elucidate mechanisms of dyspnea relief and
      improvements in postural control after inspiratory muscle training (IMT) in patients with
      COPD.

      An endurance cycle exercise test (Constant work rate (CWR) test) will be used to evaluate
      dyspnea intensity and unpleasantness at comparable breathing efforts, at comparable work
      rates on the cycle ergometer, before and after IMT. Patients will be performing a CWR test at
      75% of the peak work rate achieved during a maximal incremental cardiopulmonary exercise test
      (CPET). Before, during and after CWR cycling tests patients will rate their intensity of
      dyspnea, unpleasantness of dyspnea, breathing related-anxiety and leg discomfort using a
      modified 10- point Borg scale. Patients will be asked to report qualitative descriptors of
      dyspnea at the end of the CWR cycling test. Maximum duration of the CWR test will be recorded
      and levels of minute ventilation will be registered continuously throughout the exercise
      protocol. With this endurance exercise test the investigators will be able to assess changes
      in the onset of dyspnea (intensity and unpleasantness) and the performance in endurance
      exercise before and after IMT.

      Surface electromyography (EMG), and a multipair esophageal electrode catheter system will be
      used during CWR exercise to evaluate respiratory muscle recruitment, respiratory effort and
      neural drive to the different respiratory muscles. The catheter will be inserted to
      continuously record Pes (esophageal pressure), Pgas (gastric pressure) and EMGdi
      (electromyogram of the diaphragm muscle). PesMax (maximal esophageal pressure), PgasMax
      (maximal gastric pressure) and PdiMax (maximal transdiaphragmatic pressure) will be obtained
      during maximal sniff and cough maneuvers. Transcutaneous surface electromyography (sEMG)
      techniques will be applied to scalene, sternocleidomastoid and parasternal intercostal
      muscles to register neural drive to these respiratory muscles. With this measurements, the
      investigators will be able to assess whether there are any changes in respiratory muscle
      recruitment patterns and respiratory neural drive to the different respiratory muscles after
      IMT.

      During exercise 'Respiratory Muscle Metaboreflex' will lead to sympathetically mediated
      vasoconstriction of limb locomotor muscle, less blood and oxygen supply to active limbs
      muscle there by locomotor muscle fatigue occurred. Quadriceps twitch forces evoked by
      magnetic stimulation of femoral nerve will be assessed to measure locomotor muscle fatigue at
      identical exercise time points during CWR test before and after the intervention. With this
      technique, the investigators will be able to assess whether the onset of locomotor muscle
      fatigue is delayed after IMT.

      An isocapnic hyperpnea trial will be performed to assess respiratory muscle perfusion,
      dyspnea intensity and unpleasantness, respiratory muscle recruitment pattern, respiratory
      effort and neural respiratory drive without the work of locomotor muscle before and after
      IMT. Patients will be asked to maintain a targeted minute ventilation pattern equal to their
      breathing frequency, tidal volume and minute ventilation recorded at rest and during the
      final minute of constant load exercise test (at ~75% WRpeak). Experimenters will provide
      verbal guidance to patients to adjust the rate and depth of their breathing such that the
      target ventilation will be obtained and maintained constant within ±5%. Isocapnia will be
      maintained by having subjects inspire from a Douglas bag containing 5% CO2, 21% O2, balance
      N2 that will be connected to a two-way non-rebreathing valve (model 2700, Hans Rudolph) by a
      piece of tubing.

      Loaded breathing tests will be performed to assess dyspnea intensity and unpleasantness,
      respiratory muscle recruitment patterns, respiratory effort and neural respiratory drive.
      Patients will be asked to breathe through a tapered flow resistive loading (TFRL) device
      (powerbreathe KH1) as long as they can (3-7 minutes), the resistance will be set at 50% of
      patients' PImax. Heart rate, oxygen saturation, and number of breaths will be monitored.
      Before and after the test Borg dyspnea, inspiratory effort and unpleasantness will be
      recorded. The test will be repeated after 8 weeks of IMT, at the same resistance. Borg
      dyspnea, inspiratory effort and unpleasantness will be recorded at time limit of pre-training
      and at the symptom limit. The longest time for post training can be up to 15 minutes.

      Respiratory (i.e., intercostal, scalene and abdominal) and locomotor muscle blood flow index
      (i.e., vastus lateralis) will be simultaneously measured during isocapnic hyperpnea trials as
      well as during CWR test (at 75% of the peak work rate) before and after IMT according to a
      previously established method using Near-Infrared Spectroscopy (NIRS) and indocyanine green
      (ICG). Respiratory (i.e., intercostal, scalene, abdominal) and locomotor muscle (i.e., vastus
      lateralis) oxygen delivery will be calculated by multiplying blood flow index to arterial
      oxygen content, the latter will be calculated non-invasively by pulse oximetry. Respiratory
      (i.e., intercostal, scalene, abdominal) and locomotor muscle (i.e., vastus lateralis) oxygen
      saturation (Stio2) - an index of oxygen availability reflecting the balance between oxygen
      supply and demand-, will be recorded continuously during the trial by NIRS.

      A noninvasive technique for studying the neural processing of respiratory sensations will be
      used to assess changes in the affective unpleasantness component of dyspnea during a
      standardized loaded breathing task. Electroencephalography (EEG) will be used to measure
      respiratory related evoked potentials (RREPs) during loaded and unloaded breathing. The RREP
      recorded from EEG is a measurement of cerebral cortical activity, which is elicited by the
      activation of lung and muscle mechanoreceptors due to short inspiratory occlusions. Patients
      will be wearing EEG sensors [129 channel system, Electrical Geodesics Inc., Eugene, USA] and
      breathe through a breathing circuit with a non-rebreathing valve via a mouthpiece. The
      inspiration will be interrupted briefly for 150 milliseconds every two to six breaths by
      activation of the occlusion valve with pressurized air, which induces the RREP. Patients will
      be rating their perceived intensity and unpleasantness of dyspnea and intensity of occlusion
      on a Borg scale while inspiratory load and occlusion will be applied via a breathing valve.
      This method will be used to assess if there is less unpleasantness associated with a giving
      level of dyspnea elicited by a resistive breathing task and whether these changes are
      correlated with changes in the central processing of the dyspnea sensation.

      To evaluate postural balance, displacement of the center of pressure (CoP) in will be
      estimated from the raw force plate data using the equation: CoP = Mx/Fz (medio-lateral) and
      CoP=My/Fz (anterior-posterior). CoP will be measured during upright standing with and without
      vision, on stable and unstable (foam pad) support surface. During some conditions, local
      muscle vibration on ankle and/or back muscles will be applied to evaluate the role of
      proprioception in postural control. Furthermore, in some conditions a repetitive ballistic
      arm movement will be asked to evaluate the effect of a internal perturbation on postural
      control. Root mean square values of the CoP displacements will be used for the analysis of
      postural stability measures and mean values will be calculated for the vibration trials to
      analyze the expected directional effect. A ratio of the CoP displacements of the ankle
      muscles vibration trial regard to the back muscles vibration trial will be calculated to
      determine the proprioceptive postural control strategy.

      A sample size of 16 participants for intervention group and 8 for control group are required
      to detect a difference of one unit in dyspnea Borg-10 scale, assuming a SD of 1 unit in the
      change in dyspnea score between pre and post measurements (power 80%, level of significance
      p<0.05). These estimates are based on previous work on dyspnea during exercise. Therefore 24
      clinically stable COPD patients with inspiratory muscle weakness (PiMax<70% predicted or
      <60cmH2O) and dyspnea symptoms (BDI<7) will be included. Patients who are unable to perform
      exercise testing will be excluded.

      Patients will perform daily training consisting of two training sessions of 30 breaths
      (intensity ~50% of PiMax; 4-5 minutes per session). One session per week will be performed
      supervised at the research center. IMT will be performed using an electronic tapered flow
      resistive loading (TFRL) device [POWERbreath®KH1, HaB International Ltd., Southam, UK] for 8
      weeks. The PiMax will be measured every week in order to increase the appropriate training
      intensity to around 50% of the PiMax at that moment. The sham group will perform IMT at an
      inspiratory load that is not expected to improve inspiratory muscle function (intensity <10%
      of baseline PiMax; unchanged throughout the protocol).

      Differences in primary and secondary outcomes between groups after 8 weeks of IMT will be
      compared adjusting for baseline differences in an analysis of covariance (ANCOVA).
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Double (Participant, Outcomes Assessor)
measure: Dyspnea (Borg CR-10 scale)
time frame: Change from Baseline in Borg CR-10 scale at 8 weeks
description: Dyspnea intensity perception on a 10-point Borg scale during constant work rate cycling exercise.
Numerical value reported for intensity of dyspnea (shortness of breath) ranging from 0 (no symptoms) to 10 (maximal symptoms)
measure: Center of pressure displacement
time frame: Change from Baseline in center of pressure at 8 weeks
description: Difference in center of pressure displacement on unstable support surface during a balance task after the intervention
measure: Maximal inspiratory pressure (Pi,max)
time frame: Change from Baseline in Pi,max at 8 weeks
description: Maximal voluntary inspiratory pressure will be recorded at the mouth to assess inspiratory muscle strength (pressure generating capacity). Measurements will be performed at functional residual capacity for inspiratory respiratory pressure (maximal inspiratory pressure; Pi,max ) using the technique proposed by Black and Hyatt. (Black LF, Hyatt RE. Maximal respiratory pressures: normal values and relationship to age and sex. Am Rev Respir Dis 1969;99:696-702.) An electronic pressure transducer will be used (MicroRPM; Micromedical, Kent, UK) to register pressures. Reference values published by Rochester and Arora will be used to define percentages of normal respiratory muscle pressures. (Rochester DF, Arora NS. Respiratory muscle failure. Med Clin North Am 1983;67:573-97.)
measure: Inspiratory Muscle Endurance during a constant load breathing task
time frame: Change from Baseline in endurance time at 8 weeks
description: To measure inspiratory muscle endurance patients will be asked to breathe against a submaximal inspiratory load provided by a flow resistive loading device (POWERbreathe®KH1, HaB International Ltd., Southam, UK) until task failure. An inspiratory load will be selected that allows patients to continue breathing against the resistance for 3-7 minutes (typically between 50-60% of the Pi,max). Breathing instructions for patients will be the same as during the training sessions. Number of breaths, average duty cycle (inspiratory time as a fraction of the total respiratory cycle), average load, average power, and total work will be registered during the test by the handheld loading device. After 8 weeks of IMT the test will be repeated against an identical load and improvements in endurance time (seconds) will be registered as the main outcome. Changes in breathing parameters will be also registered.
measure: Endurance capacity during a constant load cycling exercise test
time frame: Change from Baseline in endurance cycling time at 8 weeks
description: A constant work rate (CWR) cycling test will be perform at 75% of the peak work rate achieved during a maximal incremental cardiopulmonary exercise test (CPET). Time (minute) till symptom limit during a CWR cycling will be measured.
measure: Respiratory effort
time frame: Change from Baseline in respiratory effort at 8 weeks
description: Pes-Esophageal Pressure (cmH2O) and Pgas-Gastric Pressure (cmH20) will be recorded continuously using a multipair esophageal electrode catheter system to assess respiratory effort (Pi/Pi,max). Maximal sniff and cough maneuvers will be performed to obtain Pes,max, Pgas,max, and Pdi,max values. Pdi -Transdiaphragmatic Pressure (cmH2O) will be calculated by subtraction of Pes from Pga.
measure: Neural Respiratory Drive
time frame: Change from Baseline in Neural Respiratory Drive at 8 weeks
description: Measuring neural output in term of activation of respiratory muscles using a multipair esophageal electrode catheter system. EMGdi-Diaphragm electromyogram (volt), sEMG-Transcutaneous electromyography (volt) of the scalene and intercostal muscles will be derived by using technique described by Duiverman et al. The result will be presented in the percentage of maximum activation of each respiratory muscle (%EMGmax)
measure: Ventilatory Muscle Recruitment (VMR)
time frame: Change from Baseline in Ventilatory Muscle Recruitment at 8 weeks
description: The ventilatory muscle recruitment (VMR) will be determined as the slope of the line between points of zero flow at end-expiration and end-inspiration for the Pga-Pes Plots; Increasing contribution of the diaphragm is represented by more negative slopes, while less negative slopes represent increasing contribution of inspiratory.
measure: Respiratory and locomotor muscle perfusion
time frame: Change from Baseline in respiratory and locomotor muscle blood flow at 8 weeks
description: Near infrared spectroscopy (NIRS) in combination with indocyanine green tracer (ICG) (NIRS-ICG method) will be used to simultaneously assess blood flow index (BFI) in both respiratory and locomotor muscle. Specifically, for the respiratory muscles BFI will be measured by recording the tissue ICG concentration over time (i.e., ICG concentration curve) by NIRS and will be expressed in nM/s (nanomoles per second) units. The same procedure will be applied for the locomotor muscle and BFI will also expressed as nM/s (nanomoles per second) units.
measure: Locomotor muscle fatigue (Quadriceps twitch forces)
time frame: Change from Baseline in quadriceps twitch forces at 8 weeks
description: Quadriceps twitch forces will be measured using transcutaneous magnetic twitch stimulation of the femoral nerve. Comparing the quadriceps twitch forces before and after exercise is a representation of locomotors muscle fatigue.
measure: Pulmonary Function
time frame: Change from Baseline in Pulmonary Function parameters at 8 weeks
description: Pulmonary function Spirometry and whole body plethysmography will be performed according to the European Respiratory Society guidelines for pulmonary function testing (Vmax Autobox, Sensor Medics, Bilthoven, the Netherlands). (Quanjer PH, Tammeling GJ, Cotes JE, et al. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993;16:5-40.) Changes in FEV1 (L), FVC (L), FRC (L), RV (L), IC (L) and peak inspiratory flow (L/s) will be registered.
measure: Daily Physical Activity
time frame: Change in daily steps and time in moderate to vigorous daily physical activity from Baseline at 8 weeks
description: Assessed with the Actigraph and Dynaport MoveMonitor monitor. Step per day (steps) and time (hours) of moderate to vigorous daily physical activity will be measured.
measure: Dyspnea intensity (Borg CR-10 scale)
time frame: Change from Baseline in Borg CR-10 scale at 8 weeks
description: Rating of dyspnea intensity (Borg CR-10 scale) during standardized loaded breathing tasks with occlusion events.
measure: Dyspnea unpleasantness (Borg CR-10 scale)
time frame: Change from Baseline in Borg CR-10 scale at 8 weeks
description: Rating of dyspnea unpleasantness (Borg CR-10 scale) during standardized loaded breathing tasks with occlusion events.
measure: Respiratory-related evoked potential (RREPs)
time frame: Change from Baseline in RREPs at 8 weeks
description: Respiratory-related evoked potential (RREPs) measured by means of EEG during condition of resistive load induced dyspnea and unloaded breathing.
measure: Evoked potential elicited by the geometric figures
time frame: Change from Baseline in Evoked potential at 8 weeks
description: Evoked potential elicited by the geometric figures during baseline and dyspnea condition
measure: Stress level
time frame: Change from Baseline in stress level at 8 weeks
description: Stress level before, during and after test intermittent dyspnea challenges will be measured using distress thermometer, rating on the scale 1 to 10.
measure: Salivary cortisol levels
time frame: Change from Baseline in salivary cortisol levels at 8 weeks
description: Salivary cortisol levels (nmol/l) before, during and after test intermittent dyspnea challenges was collected. The level between >7 and <17 nmol/l considers standard cortisol levels.
arm group label: Inspiratory Muscle Strength Training
arm group type: Experimental
description: High intensity inspiratory muscle training
arm group label: Inspiratory Muscle Endurance Training
arm group type: Sham Comparator
description: Sham inspiratory muscle training at low intensity
intervention type: Procedure
intervention name: Inspiratory Muscle Strength Training
description: IMT will be performed using a variable flow resistive loading device (POWERbreathe®KH1, HaB International Ltd., Southam, UK). The device is able to store training parameters of up to 40 sessions. Most training sessions during this RCT will be performed by patients at their homes without supervision. The intervention group (strength IMT) will perform two daily sessions of 30 breaths. Measurements of Pi,max will be performed every week and training loads will be increased continuously to maintain at least 40-50% of the actual Pi,max values. Each week, one training session will be performed under supervision. Training load will be increased during this session.
arm group label: Inspiratory Muscle Strength Training
other name: Electronic Variable Flow Resistive Loading IMT Device
other name: POWERbreathe®KH1, HaB International Ltd., Southam, UK
intervention type: Procedure
intervention name: Inspiratory Muscle Endurance Training
description: IMT will be performed using a variable flow resistive loading device (POWERbreathe®KH1, HaB International Ltd., Southam, UK). The device is able to store training parameters of up to 40 sessions. Most training sessions during this RCT will be performed by patients at their homes without supervision. The sham group (endurance IMT) will perform three daily sessions of 30 breaths and will train at a constant inspiratory load of no more than 10% of their initial Pi,max. Each week, one training session will be performed under supervision.
arm group label: Inspiratory Muscle Endurance Training
other name: Electronic Variable Flow Resistive Loading IMT Device
other name: POWERbreathe®KH1, HaB International Ltd., Southam, UK
criteria: 
gender: All
minimum age: 40 Years
maximum age: 90 Years
healthy volunteers: No
last name: Rik Gosselink, PhD
role: Principal Investigator
affiliation: Vicerector of Student Affairs KU Leuven
facility: 
country: Belgium
responsible party type: Principal Investigator
investigator affiliation: KU Leuven
investigator full name: Daniel Langer
investigator title: Principal Investigator
mesh term: Muscle Weakness
mesh term: Dyspnea
mesh term: Respiratory Aspiration