<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03232216</url>
  </required_header>
  <id_info>
    <org_study_id>ViDco</org_study_id>
    <nct_id>NCT03232216</nct_id>
  </id_info>
  <brief_title>Vitamin D Supplementation and Tibia Fracture. Does it Improve Healing Rate?</brief_title>
  <acronym>ViDco</acronym>
  <official_title>Vitamin D Supplementation in Patients With Operated Tibia Fracture and Low Vitamin D. Does it Improve Healing Rate?. Randomized Controlled Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Hospital del Trabajador de Santiago</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Hospital del Trabajador de Santiago</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This study evaluates the effect of Vitamin D3 supplementation in healing rate of tibia&#xD;
      fractures in adult patients with low vitamin D. Half of participants will receive Vitamin D3&#xD;
      supplementation while the other will receive placebo.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">November 21, 2017</start_date>
  <completion_date type="Anticipated">August 18, 2023</completion_date>
  <primary_completion_date type="Anticipated">August 18, 2021</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Prevention</primary_purpose>
    <masking>Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Fracture non union</measure>
    <time_frame>2 years</time_frame>
    <description>Rate of fracture non union in each group</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Prevalence of low vitamin D in adults with tibia fracture</measure>
    <time_frame>10 days</time_frame>
    <description>Using the first measurement of 25 hydroxyvitamin D</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Time of fracture healing</measure>
    <time_frame>2 years</time_frame>
    <description>Time that lasted consolidation, from surgery</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Short Form 36 score (SF-36)</measure>
    <time_frame>2 years</time_frame>
    <description>Health associated quality of life</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>EuroQol five dimensions questionnaire (EQ-5D)</measure>
    <time_frame>2 years</time_frame>
    <description>Generic health status measurement</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Knee Range of movement</measure>
    <time_frame>2 years</time_frame>
    <description>Knee flexion and extension in degrees</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Ankle Range of movement</measure>
    <time_frame>2 years</time_frame>
    <description>Ankle flexion and extension in degrees</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Superficial Infections</measure>
    <time_frame>2 years</time_frame>
    <description>Incidence of superficial infections in each group</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Deep infections</measure>
    <time_frame>2 years</time_frame>
    <description>Incidence of superficial infections in each group</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Visual Analogue Scale (VAS)</measure>
    <time_frame>2 years</time_frame>
    <description>Pain measurement using VAS</description>
  </secondary_outcome>
  <number_of_arms>4</number_of_arms>
  <enrollment type="Anticipated">682</enrollment>
  <condition>Tibial Fractures</condition>
  <condition>Vitamin D Deficiency</condition>
  <condition>Fracture Healing</condition>
  <arm_group>
    <arm_group_label>Vitamin D3 supplementation. Deficiency.</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Vitamin D3 50.000 UI in each packet of powder for solution. Two packets every week for 5 weeks.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Placebo. Deficiency.</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Placebo of Vitamin D3 50.000 UI in each packet of powder for oral solution. Two packets every week for 5 weeks.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Vitamin D3 supplementation.Insufficiency</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Vitamin D3 50.000 UI in each packet of powder for oral solution. Two packets every week for 3 weeks.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Placebo. Insufficiency.</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Placebo of Vitamin D3 50.000 UI in each packet of powder for oral solution. Two packets every week for 3 weeks.</description>
  </arm_group>
  <intervention>
    <intervention_type>Dietary Supplement</intervention_type>
    <intervention_name>Vitamin D3.</intervention_name>
    <description>Vitamin D3 50.000 UI in each packet of powder for oral solution.</description>
    <arm_group_label>Vitamin D3 supplementation. Deficiency.</arm_group_label>
    <arm_group_label>Vitamin D3 supplementation.Insufficiency</arm_group_label>
    <other_name>Cholecalciferol</other_name>
  </intervention>
  <intervention>
    <intervention_type>Dietary Supplement</intervention_type>
    <intervention_name>Placebo</intervention_name>
    <description>Placebo of Vitamin D3 50.000 UI in each packet of powder for oral solution.</description>
    <arm_group_label>Placebo. Deficiency.</arm_group_label>
    <arm_group_label>Placebo. Insufficiency.</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Tibial fracture&#xD;
&#xD;
          -  ASA physical status classification system I-II.&#xD;
&#xD;
          -  25 hydroxyvitamin D below 30ng/ml)&#xD;
&#xD;
          -  Fracture treatment with reamed intramedullary nail&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Open Fractures Gustillo III B and III C&#xD;
&#xD;
          -  Closed Soft tissue injury with Tscherne classification of III&#xD;
&#xD;
          -  Acute Compartment Syndrome&#xD;
&#xD;
          -  Pathology fractures (That occur in abnormal bone, for example in the presence of&#xD;
             tumor, cyst or Paget disease)&#xD;
&#xD;
          -  Other Fractures in lower limbs or spine that does not allow full weight bearing of the&#xD;
             operated tibia after 4 weeks&#xD;
&#xD;
          -  More than 7 days of evolution from fracture occurrence&#xD;
&#xD;
          -  Diabetes mellitus with HbA1c more or equal than 7%&#xD;
&#xD;
          -  Peripheral vascular disease&#xD;
&#xD;
          -  Rickets&#xD;
&#xD;
          -  Pre-existing disorders of the metabolism of Vitamin D and/or homeostasis of calcium&#xD;
             and phosphorous (ie. Hepatic insufficiency, congenital defects of the vitamin D&#xD;
             metabolism, disorders of the parathyroid glands, hypo or hyper calcemia)&#xD;
&#xD;
          -  Renal failure with glomerular filtration rate below 60ml/min according to MDRD-4.&#xD;
&#xD;
          -  Patients using nephrotoxic medications in high doses, requiring periodical monitoring&#xD;
             of glomerular filtration rate&#xD;
&#xD;
          -  Patients undergoing with nephrotic syndrome or that suffered it in the past&#xD;
&#xD;
          -  Patients that suffered nephrolithiasis or urolithiasis&#xD;
&#xD;
          -  Pregnant women&#xD;
&#xD;
          -  Patients with allergy to vitamin D or other contraindications for vitamin D3&#xD;
             prescription&#xD;
&#xD;
          -  Patients that are taking multivitamin supplements containing vitamin D and will not&#xD;
             suspend taking them during the study.&#xD;
&#xD;
          -  Patients that are not able to swallow a cup of water&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>59 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Sebastian Drago</last_name>
    <role>Principal Investigator</role>
    <affiliation>Hospital del Trabajador de Santiago</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Sebastian Drago, MD</last_name>
    <phone>+56992191310</phone>
    <email>sdrago@hts.cl</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Jose Rojas, MD</last_name>
    <phone>+56991671221</phone>
    <email>josemrojasf@gmail.com</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Hospital del Trabajador de Santiago</name>
      <address>
        <city>Santiago</city>
        <state>Metropolitana</state>
        <zip>8320000</zip>
        <country>Chile</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Sebastián R Drago, MD</last_name>
      <phone>+56992191310</phone>
      <email>sebadrago@gmail.com</email>
    </contact>
  </location>
  <location_countries>
    <country>Chile</country>
  </location_countries>
  <reference>
    <citation>Manson JE, Brannon PM, Rosen CJ, Taylor CL. Vitamin D Deficiency - Is There Really a Pandemic? N Engl J Med. 2016 Nov 10;375(19):1817-1820. doi: 10.1056/NEJMp1608005. No abstract available.</citation>
    <PMID>27959647</PMID>
  </reference>
  <reference>
    <citation>Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6. Erratum In: J Clin Endocrinol Metab. 2011 Dec;96(12):3908.</citation>
    <PMID>21646368</PMID>
  </reference>
  <reference>
    <citation>Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81. doi: 10.1056/NEJMra070553. No abstract available.</citation>
    <PMID>17634462</PMID>
  </reference>
  <reference>
    <citation>Schwartz JB, Kane L, Bikle D. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan;64(1):65-72. doi: 10.1111/jgs.13774.</citation>
    <PMID>26782853</PMID>
  </reference>
  <reference>
    <citation>Talib HJ, Ponnapakkam T, Gensure R, Cohen HW, Coupey SM. Treatment of Vitamin D Deficiency in Predominantly Hispanic and Black Adolescents: A Randomized Clinical Trial. J Pediatr. 2016 Mar;170:266-72.e1. doi: 10.1016/j.jpeds.2015.11.025. Epub 2015 Dec 18.</citation>
    <PMID>26707619</PMID>
  </reference>
  <reference>
    <citation>Vieth, R: The pharmacology of vitamin D. Vitam D 2011;1041-1066. doi:10.1016/B978-0-12-381978-9.10057-5</citation>
  </reference>
  <reference>
    <citation>Antonova E, Le TK, Burge R, Mershon J. Tibia shaft fractures: costly burden of nonunions. BMC Musculoskelet Disord. 2013 Jan 26;14:42. doi: 10.1186/1471-2474-14-42.</citation>
    <PMID>23351958</PMID>
  </reference>
  <reference>
    <citation>Khaw KT, Stewart AW, Waayer D, Lawes CMM, Toop L, Camargo CA Jr, Scragg R. Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomised, double-blind, placebo-controlled ViDA trial. Lancet Diabetes Endocrinol. 2017 Jun;5(6):438-447. doi: 10.1016/S2213-8587(17)30103-1. Epub 2017 Apr 28.</citation>
    <PMID>28461159</PMID>
  </reference>
  <results_reference>
    <citation>Sprague S, Petrisor B, Scott T, Devji T, Phillips M, Spurr H, Bhandari M, Slobogean GP. What Is the Role of Vitamin D Supplementation in Acute Fracture Patients? A Systematic Review and Meta-Analysis of the Prevalence of Hypovitaminosis D and Supplementation Efficacy. J Orthop Trauma. 2016 Feb;30(2):53-63. doi: 10.1097/BOT.0000000000000455.</citation>
    <PMID>26429406</PMID>
  </results_reference>
  <results_reference>
    <citation>Carrasco G M, Dominguez De L A, Martinez F G, Ihle S S, Rojas A V, Foradori C A, Marin L PP. [Vitamin D levels in older healthy Chilean adults and their association with functional performance]. Rev Med Chil. 2014 Nov;142(11):1385-91. doi: 10.4067/S0034-98872014001100004. Spanish.</citation>
    <PMID>25694283</PMID>
  </results_reference>
  <results_reference>
    <citation>Schweitzer D, Amenabar PP, Botello E, Lopez M, Saavedra Y, Klaber I. [Vitamin D levels among Chilean older subjects with low energy hip fracture]. Rev Med Chil. 2016 Feb;144(2):175-80. doi: 10.4067/S0034-98872016000200005. Spanish.</citation>
    <PMID>27092671</PMID>
  </results_reference>
  <results_reference>
    <citation>Souberbielle JC, Massart C, Brailly-Tabard S, Cavalier E, Chanson P. Prevalence and determinants of vitamin D deficiency in healthy French adults: the VARIETE study. Endocrine. 2016 Aug;53(2):543-50. doi: 10.1007/s12020-016-0960-3. Epub 2016 Apr 22.</citation>
    <PMID>27106800</PMID>
  </results_reference>
  <results_reference>
    <citation>Yu S, Fang H, Han J, Cheng X, Xia L, Li S, Liu M, Tao Z, Wang L, Hou L, Qin X, Li P, Zhang R, Su W, Qiu L. The high prevalence of hypovitaminosis D in China: a multicenter vitamin D status survey. Medicine (Baltimore). 2015 Feb;94(8):e585. doi: 10.1097/MD.0000000000000585. Erratum In: Medicine (Baltimore). 2015 Mar;94(11):1.</citation>
    <PMID>25715263</PMID>
  </results_reference>
  <results_reference>
    <citation>Bodendorfer BM, Cook JL, Robertson DS, Della Rocca GJ, Volgas DA, Stannard JP, Crist BD. Do 25-Hydroxyvitamin D Levels Correlate With Fracture Complications? J Orthop Trauma. 2016 Sep;30(9):e312-7. doi: 10.1097/BOT.0000000000000639.</citation>
    <PMID>27253482</PMID>
  </results_reference>
  <results_reference>
    <citation>Bell A, Templeman D, Weinlein JC. Nonunion of the Femur and Tibia: An Update. Orthop Clin North Am. 2016 Apr;47(2):365-75. doi: 10.1016/j.ocl.2015.09.010.</citation>
    <PMID>26772945</PMID>
  </results_reference>
  <results_reference>
    <citation>Duan X, Al-Qwbani M, Zeng Y, Zhang W, Xiang Z. Intramedullary nailing for tibial shaft fractures in adults. Cochrane Database Syst Rev. 2012 Jan 18;1:CD008241. doi: 10.1002/14651858.CD008241.pub2.</citation>
    <PMID>22258982</PMID>
  </results_reference>
  <verification_date>November 2017</verification_date>
  <study_first_submitted>July 25, 2017</study_first_submitted>
  <study_first_submitted_qc>July 25, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">July 27, 2017</study_first_posted>
  <last_update_submitted>November 21, 2017</last_update_submitted>
  <last_update_submitted_qc>November 21, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">November 24, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Hospital del Trabajador de Santiago</investigator_affiliation>
    <investigator_full_name>Sebastián Drago Pérez</investigator_full_name>
    <investigator_title>Orthopedic Surgeon</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Vitamin D Deficiency</mesh_term>
    <mesh_term>Fractures, Bone</mesh_term>
    <mesh_term>Tibial Fractures</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Vitamin D</mesh_term>
    <mesh_term>Cholecalciferol</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03232216
org study id: ViDco
nct id: NCT03232216
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
This study evaluates the effect of Vitamin D3 supplementation in healing rate of tibia
      fractures in adult patients with low vitamin D. Half of participants will receive Vitamin D3
      supplementation while the other will receive placebo.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Prevention
masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
measure: Fracture non union
time frame: 2 years
description: Rate of fracture non union in each group
measure: Prevalence of low vitamin D in adults with tibia fracture
time frame: 10 days
description: Using the first measurement of 25 hydroxyvitamin D
measure: Time of fracture healing
time frame: 2 years
description: Time that lasted consolidation, from surgery
measure: Short Form 36 score (SF-36)
time frame: 2 years
description: Health associated quality of life
measure: EuroQol five dimensions questionnaire (EQ-5D)
time frame: 2 years
description: Generic health status measurement
measure: Knee Range of movement
time frame: 2 years
description: Knee flexion and extension in degrees
measure: Ankle Range of movement
time frame: 2 years
description: Ankle flexion and extension in degrees
measure: Superficial Infections
time frame: 2 years
description: Incidence of superficial infections in each group
measure: Deep infections
time frame: 2 years
description: Incidence of superficial infections in each group
measure: Visual Analogue Scale (VAS)
time frame: 2 years
description: Pain measurement using VAS
arm group label: Vitamin D3 supplementation. Deficiency.
arm group type: Experimental
description: Vitamin D3 50.000 UI in each packet of powder for solution. Two packets every week for 5 weeks.
arm group label: Placebo. Deficiency.
arm group type: Placebo Comparator
description: Placebo of Vitamin D3 50.000 UI in each packet of powder for oral solution. Two packets every week for 5 weeks.
arm group label: Vitamin D3 supplementation.Insufficiency
arm group type: Experimental
description: Vitamin D3 50.000 UI in each packet of powder for oral solution. Two packets every week for 3 weeks.
arm group label: Placebo. Insufficiency.
arm group type: Placebo Comparator
description: Placebo of Vitamin D3 50.000 UI in each packet of powder for oral solution. Two packets every week for 3 weeks.
intervention type: Dietary Supplement
intervention name: Vitamin D3.
description: Vitamin D3 50.000 UI in each packet of powder for oral solution.
arm group label: Vitamin D3 supplementation. Deficiency.
arm group label: Vitamin D3 supplementation.Insufficiency
other name: Cholecalciferol
intervention type: Dietary Supplement
intervention name: Placebo
description: Placebo of Vitamin D3 50.000 UI in each packet of powder for oral solution.
arm group label: Placebo. Deficiency.
arm group label: Placebo. Insufficiency.
criteria: 
gender: All
minimum age: 18 Years
maximum age: 59 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Sebastian Drago
role: Principal Investigator
affiliation: Hospital del Trabajador de Santiago
last name: Sebastian Drago, MD
phone: +56992191310
email: sdrago@hts.cl
last name: Jose Rojas, MD
phone: +56991671221
email: josemrojasf@gmail.com
facility: 
status: Recruiting
contact: 
country: Chile
citation: Manson JE, Brannon PM, Rosen CJ, Taylor CL. Vitamin D Deficiency - Is There Really a Pandemic? N Engl J Med. 2016 Nov 10;375(19):1817-1820. doi: 10.1056/NEJMp1608005. No abstract available.
PMID: 27959647
citation: Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6. Erratum In: J Clin Endocrinol Metab. 2011 Dec;96(12):3908.
PMID: 21646368
citation: Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81. doi: 10.1056/NEJMra070553. No abstract available.
PMID: 17634462
citation: Schwartz JB, Kane L, Bikle D. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. J Am Geriatr Soc. 2016 Jan;64(1):65-72. doi: 10.1111/jgs.13774.
PMID: 26782853
citation: Talib HJ, Ponnapakkam T, Gensure R, Cohen HW, Coupey SM. Treatment of Vitamin D Deficiency in Predominantly Hispanic and Black Adolescents: A Randomized Clinical Trial. J Pediatr. 2016 Mar;170:266-72.e1. doi: 10.1016/j.jpeds.2015.11.025. Epub 2015 Dec 18.
PMID: 26707619
citation: Vieth, R: The pharmacology of vitamin D. Vitam D 2011;1041-1066. doi:10.1016/B978-0-12-381978-9.10057-5
citation: Antonova E, Le TK, Burge R, Mershon J. Tibia shaft fractures: costly burden of nonunions. BMC Musculoskelet Disord. 2013 Jan 26;14:42. doi: 10.1186/1471-2474-14-42.
PMID: 23351958
citation: Khaw KT, Stewart AW, Waayer D, Lawes CMM, Toop L, Camargo CA Jr, Scragg R. Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomised, double-blind, placebo-controlled ViDA trial. Lancet Diabetes Endocrinol. 2017 Jun;5(6):438-447. doi: 10.1016/S2213-8587(17)30103-1. Epub 2017 Apr 28.
PMID: 28461159
citation: Sprague S, Petrisor B, Scott T, Devji T, Phillips M, Spurr H, Bhandari M, Slobogean GP. What Is the Role of Vitamin D Supplementation in Acute Fracture Patients? A Systematic Review and Meta-Analysis of the Prevalence of Hypovitaminosis D and Supplementation Efficacy. J Orthop Trauma. 2016 Feb;30(2):53-63. doi: 10.1097/BOT.0000000000000455.
PMID: 26429406
citation: Carrasco G M, Dominguez De L A, Martinez F G, Ihle S S, Rojas A V, Foradori C A, Marin L PP. [Vitamin D levels in older healthy Chilean adults and their association with functional performance]. Rev Med Chil. 2014 Nov;142(11):1385-91. doi: 10.4067/S0034-98872014001100004. Spanish.
PMID: 25694283
citation: Schweitzer D, Amenabar PP, Botello E, Lopez M, Saavedra Y, Klaber I. [Vitamin D levels among Chilean older subjects with low energy hip fracture]. Rev Med Chil. 2016 Feb;144(2):175-80. doi: 10.4067/S0034-98872016000200005. Spanish.
PMID: 27092671
citation: Souberbielle JC, Massart C, Brailly-Tabard S, Cavalier E, Chanson P. Prevalence and determinants of vitamin D deficiency in healthy French adults: the VARIETE study. Endocrine. 2016 Aug;53(2):543-50. doi: 10.1007/s12020-016-0960-3. Epub 2016 Apr 22.
PMID: 27106800
citation: Yu S, Fang H, Han J, Cheng X, Xia L, Li S, Liu M, Tao Z, Wang L, Hou L, Qin X, Li P, Zhang R, Su W, Qiu L. The high prevalence of hypovitaminosis D in China: a multicenter vitamin D status survey. Medicine (Baltimore). 2015 Feb;94(8):e585. doi: 10.1097/MD.0000000000000585. Erratum In: Medicine (Baltimore). 2015 Mar;94(11):1.
PMID: 25715263
citation: Bodendorfer BM, Cook JL, Robertson DS, Della Rocca GJ, Volgas DA, Stannard JP, Crist BD. Do 25-Hydroxyvitamin D Levels Correlate With Fracture Complications? J Orthop Trauma. 2016 Sep;30(9):e312-7. doi: 10.1097/BOT.0000000000000639.
PMID: 27253482
citation: Bell A, Templeman D, Weinlein JC. Nonunion of the Femur and Tibia: An Update. Orthop Clin North Am. 2016 Apr;47(2):365-75. doi: 10.1016/j.ocl.2015.09.010.
PMID: 26772945
citation: Duan X, Al-Qwbani M, Zeng Y, Zhang W, Xiang Z. Intramedullary nailing for tibial shaft fractures in adults. Cochrane Database Syst Rev. 2012 Jan 18;1:CD008241. doi: 10.1002/14651858.CD008241.pub2.
PMID: 22258982
responsible party type: Principal Investigator
investigator affiliation: Hospital del Trabajador de Santiago
investigator full name: Sebastián Drago Pérez
investigator title: Orthopedic Surgeon
mesh term: Vitamin D Deficiency
mesh term: Fractures, Bone
mesh term: Tibial Fractures
mesh term: Vitamin D
mesh term: Cholecalciferol
sharing ipd: No