<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03285360</url>
  </required_header>
  <id_info>
    <org_study_id>CairoU-DEzz</org_study_id>
    <nct_id>NCT03285360</nct_id>
  </id_info>
  <brief_title>Effectiveness of Bioactiveglass Air Abrasion Versus Fluoride Varnish in Management of Dentin Hypersensitivity</brief_title>
  <official_title>Effectiveness of Sylc Air Abrasion Bioactive Glass Technology Versus Fluoride Varnish Application in Management of Hypersensitivity of Non-Carious Cervical Lesions: Randomized Clinical Trial.</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Cairo University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Cairo University</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
    <is_us_export>No</is_us_export>
  </oversight_info>
  <brief_summary>
    <textblock>
      Will the use of Bioactive glass with air abrasion technology (Sylc) compared to Fluoride&#xD;
      Varnish (Biflourid 10) affects the degree of pain in patients complaining from&#xD;
      hypersensitivity due to non-carious lesions?&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      -  Population: Patients complaining from Dentin Hypersensitivity due to non-carious&#xD;
           lesions.&#xD;
&#xD;
        -  Intervention: Sylc, Air Abrasion Bioactive glass (Denfotex Research Ltd.)&#xD;
&#xD;
        -  Comparison: BiFlourid 10, Fluoride Varnish (VOCO, Germany)&#xD;
&#xD;
        -  Outcome measures: Dentin Hypersensitivity&#xD;
&#xD;
      Outcome name Measuring device Measuring unit Dentin Hypersensitivity&#xD;
&#xD;
        -  Thermal&#xD;
&#xD;
        -  Tactile&#xD;
&#xD;
        -  Evaporative&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">October 1, 2017</start_date>
  <completion_date type="Actual">January 1, 2019</completion_date>
  <primary_completion_date type="Actual">December 1, 2018</primary_completion_date>
  <phase>Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>Dentin Hypersensitivity</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Outcomes Assessor)</masking>
    <masking_description>double blinded</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Pain due to dentin hypersensitivity (evaporative stimulus)</measure>
    <time_frame>2 minutes after treatment</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (evaporative stimulus)</measure>
    <time_frame>1 week</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (evaporative stimulus)</measure>
    <time_frame>2 weeks</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (evaporative stimulus)</measure>
    <time_frame>3 weeks</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (evaporative stimulus)</measure>
    <time_frame>4 weeks</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (evaporative stimulus)</measure>
    <time_frame>6 months</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (evaporative stimulus)</measure>
    <time_frame>12 months</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (tactile stimulus)</measure>
    <time_frame>2 minutes after treatment</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (tactile stimulus)</measure>
    <time_frame>1 week</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (tactile stimulus)</measure>
    <time_frame>2 weeks</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (tactile stimulus)</measure>
    <time_frame>3 weeks</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (tactile stimulus)</measure>
    <time_frame>4 weeks</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (tactile stimulus)</measure>
    <time_frame>6 months</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (tactile stimulus)</measure>
    <time_frame>12 months</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (thermal stimulus)</measure>
    <time_frame>2 minutes after treatment</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (thermal stimulus)</measure>
    <time_frame>1 week</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (thermal stimulus)</measure>
    <time_frame>2 weeks</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (thermal stimulus)</measure>
    <time_frame>3 weeks</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (thermal stimulus)</measure>
    <time_frame>4 weeks</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (thermal stimulus)</measure>
    <time_frame>6 months</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain due to dentin hypersensitivity (thermal stimulus)</measure>
    <time_frame>12 months</time_frame>
    <description>Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">50</enrollment>
  <condition>Hypersensitivity Dentin</condition>
  <condition>Tooth Hypersensitivity</condition>
  <arm_group>
    <arm_group_label>sylc bioactive glass</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Sylc is a dry powder (calcium sodium phosphosilicate), based on NovaMin powder. Bottle of small and coarse particles will be used for the treatment.&#xD;
Steps:&#xD;
Isolation: D.M. will make proper isolation for the teeth using cotton rolls.&#xD;
Hand piece: NSK Prophymate Neo will be used to deliver the powder particles on the sensitive areas. Air stream adjusted at 40-46 psi.&#xD;
Application: The hand piece will be held at constant distance (3-4mm) away from the tooth surface, with 60-80 degrees on the buccal surfaces. The powder will be applied for 5-10 seconds per tooth in a circular movement.&#xD;
Suction: High volume suction will be used on lingual side of the teeth to suck any particles, and avoid patient from swallowing it.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>fluoride varnish (Bifluorid 10)</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>fluoride varnish Bifluorid 10(by VOCO) will be used. It is a rapid- drying suspension of equal amounts of sodium fluoride and calcium fluoride.&#xD;
The single dose form will be used, to make sure the amount of fluoride varnish used is standardized.&#xD;
Steps:&#xD;
Preparation: The tooth will be properly cleaned, and the surface will be air-dried.&#xD;
Dispensing: The foil will be pierced using a micro- tim, the opening will be enlarged, the brush will be wet in a circular movement.&#xD;
Application: Thin coat will be applied on the tooth surface. The varnish will be left from 10-20 seconds then air dried.&#xD;
Concerning the storage of the Bifluoride 10, it will be stored in refrigerator at the operative clinic to avoid exposure to high temperature or sunlight.</description>
  </arm_group>
  <intervention>
    <intervention_type>Combination Product</intervention_type>
    <intervention_name>Sylc</intervention_name>
    <description>a dry powder (calcium sodium phosphosilicate), based on NovaMin powder. Bottle of small and coarse particles will be used for the treatment</description>
    <arm_group_label>sylc bioactive glass</arm_group_label>
    <other_name>Sylc bioactive glass</other_name>
  </intervention>
  <intervention>
    <intervention_type>Combination Product</intervention_type>
    <intervention_name>fluoride varnish (Bifluorid 10)</intervention_name>
    <description>It is a rapid- drying suspension of equal amounts of sodium fluoride and calcium fluoride.</description>
    <arm_group_label>fluoride varnish (Bifluorid 10)</arm_group_label>
    <other_name>Bifluorid 10</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Males or females.&#xD;
&#xD;
          -  Age: 18-70 years old.&#xD;
&#xD;
          -  Patients with good oral hygiene.&#xD;
&#xD;
          -  Co-operative patients who show interest to participate in the study.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Patients with bad oral hygiene.&#xD;
&#xD;
          -  Patients with orthodontic appliances, or bridge work that might interfere with&#xD;
             evaluation.&#xD;
&#xD;
          -  Patients who did any periodontal surgeries within the previous 6 months.&#xD;
&#xD;
          -  Patients who are allergic to any ingredients will be used in the study.&#xD;
&#xD;
          -  Pregnant and lactating women.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>70 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Dina E Mohamed, Master</last_name>
    <role>Principal Investigator</role>
    <affiliation>Assistant lecturer, Conservative Dentistry Department, Faculty of Dentistry, Cairo University</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Faculty of dentistry</name>
      <address>
        <city>Cairo</city>
        <state>Cairo Governorate</state>
        <country>Egypt</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Egypt</country>
  </location_countries>
  <verification_date>January 2019</verification_date>
  <study_first_submitted>September 11, 2017</study_first_submitted>
  <study_first_submitted_qc>September 14, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">September 18, 2017</study_first_posted>
  <last_update_submitted>January 30, 2019</last_update_submitted>
  <last_update_submitted_qc>January 30, 2019</last_update_submitted_qc>
  <last_update_posted type="Actual">January 31, 2019</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Cairo University</investigator_affiliation>
    <investigator_full_name>Dina Ezz</investigator_full_name>
    <investigator_title>Principal investigator</investigator_title>
  </responsible_party>
  <keyword>Bifluoride, sylc, hypersensitivity,</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Dentin Sensitivity</mesh_term>
    <mesh_term>Hypersensitivity</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Fluorides</mesh_term>
    <mesh_term>Fluorides, Topical</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03285360
org study id: CairoU-DEzz
nct id: NCT03285360
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
is us export: No
Will the use of Bioactive glass with air abrasion technology (Sylc) compared to Fluoride
      Varnish (Biflourid 10) affects the degree of pain in patients complaining from
      hypersensitivity due to non-carious lesions?
-  Population: Patients complaining from Dentin Hypersensitivity due to non-carious
           lesions.

        -  Intervention: Sylc, Air Abrasion Bioactive glass (Denfotex Research Ltd.)

        -  Comparison: BiFlourid 10, Fluoride Varnish (VOCO, Germany)

        -  Outcome measures: Dentin Hypersensitivity

      Outcome name Measuring device Measuring unit Dentin Hypersensitivity

        -  Thermal

        -  Tactile

        -  Evaporative
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: Dentin Hypersensitivity
primary purpose: Treatment
masking: Double (Participant, Outcomes Assessor)
masking description: double blinded
measure: Pain due to dentin hypersensitivity (evaporative stimulus)
time frame: 2 minutes after treatment
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (evaporative stimulus)
time frame: 1 week
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (evaporative stimulus)
time frame: 2 weeks
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (evaporative stimulus)
time frame: 3 weeks
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (evaporative stimulus)
time frame: 4 weeks
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (evaporative stimulus)
time frame: 6 months
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (evaporative stimulus)
time frame: 12 months
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by air blast measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (tactile stimulus)
time frame: 2 minutes after treatment
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (tactile stimulus)
time frame: 1 week
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (tactile stimulus)
time frame: 2 weeks
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (tactile stimulus)
time frame: 3 weeks
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (tactile stimulus)
time frame: 4 weeks
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (tactile stimulus)
time frame: 6 months
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (tactile stimulus)
time frame: 12 months
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by tactile stimulation with a probe measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (thermal stimulus)
time frame: 2 minutes after treatment
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (thermal stimulus)
time frame: 1 week
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (thermal stimulus)
time frame: 2 weeks
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (thermal stimulus)
time frame: 3 weeks
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (thermal stimulus)
time frame: 4 weeks
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (thermal stimulus)
time frame: 6 months
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS
measure: Pain due to dentin hypersensitivity (thermal stimulus)
time frame: 12 months
description: Pain arising from dentin hypersensitivity in non-carious lesions stimulated by cold water measured by a 10 cm visual analogue scale VAS
arm group label: sylc bioactive glass
arm group type: Experimental
description: Sylc is a dry powder (calcium sodium phosphosilicate), based on NovaMin powder. Bottle of small and coarse particles will be used for the treatment.
Steps:
Isolation: D.M. will make proper isolation for the teeth using cotton rolls.
Hand piece: NSK Prophymate Neo will be used to deliver the powder particles on the sensitive areas. Air stream adjusted at 40-46 psi.
Application: The hand piece will be held at constant distance (3-4mm) away from the tooth surface, with 60-80 degrees on the buccal surfaces. The powder will be applied for 5-10 seconds per tooth in a circular movement.
Suction: High volume suction will be used on lingual side of the teeth to suck any particles, and avoid patient from swallowing it.
arm group label: fluoride varnish (Bifluorid 10)
arm group type: Active Comparator
description: fluoride varnish Bifluorid 10(by VOCO) will be used. It is a rapid- drying suspension of equal amounts of sodium fluoride and calcium fluoride.
The single dose form will be used, to make sure the amount of fluoride varnish used is standardized.
Steps:
Preparation: The tooth will be properly cleaned, and the surface will be air-dried.
Dispensing: The foil will be pierced using a micro- tim, the opening will be enlarged, the brush will be wet in a circular movement.
Application: Thin coat will be applied on the tooth surface. The varnish will be left from 10-20 seconds then air dried.
Concerning the storage of the Bifluoride 10, it will be stored in refrigerator at the operative clinic to avoid exposure to high temperature or sunlight.
intervention type: Combination Product
intervention name: Sylc
description: a dry powder (calcium sodium phosphosilicate), based on NovaMin powder. Bottle of small and coarse particles will be used for the treatment
arm group label: sylc bioactive glass
other name: Sylc bioactive glass
intervention type: Combination Product
intervention name: fluoride varnish (Bifluorid 10)
description: It is a rapid- drying suspension of equal amounts of sodium fluoride and calcium fluoride.
arm group label: fluoride varnish (Bifluorid 10)
other name: Bifluorid 10
criteria: 
gender: All
minimum age: 18 Years
maximum age: 70 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Dina E Mohamed, Master
role: Principal Investigator
affiliation: Assistant lecturer, Conservative Dentistry Department, Faculty of Dentistry, Cairo University
facility: 
country: Egypt
responsible party type: Principal Investigator
investigator affiliation: Cairo University
investigator full name: Dina Ezz
investigator title: Principal investigator
mesh term: Dentin Sensitivity
mesh term: Hypersensitivity
mesh term: Fluorides
mesh term: Fluorides, Topical
sharing ipd: Undecided