<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03241277</url>
  </required_header>
  <id_info>
    <org_study_id>33267314.9.0000.0068</org_study_id>
    <secondary_id>821.780</secondary_id>
    <nct_id>NCT03241277</nct_id>
  </id_info>
  <brief_title>Nonsurgical Periodontal Treatment in Patients With Social Phobia</brief_title>
  <acronym>NSPTSP</acronym>
  <official_title>Evaluation of Nonsurgical Periodontal Treatment in Patients With Social Phobia: a Randomized Controlled Clinical Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Sao Paulo General Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Fundação de Amparo à Pesquisa do Estado de São Paulo</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Sao Paulo General Hospital</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Objective: To investigate the impact of nonsurgical periodontal treatment in patients with&#xD;
      social anxiety disorder (SAD) and controls without phobia.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Study design: randomized controlled trial. Setting: Institute of Psychiatry from FMUSP&#xD;
      (Ipq-FMUSP). Subjects: patients seeking for Social Phobia treatment at IPq-FMUSP ( before and&#xD;
      under treatment). Controls: Hospital staff at the HC-FMUSP or volunteers from a list of other&#xD;
      studies conducted at the Ipq-FMUSP. Methods: Dental evaluation: probing depth, clinical&#xD;
      attachment level and bleeding on probing will be recorded at 6 sites per tooth, as well as&#xD;
      the plaque and/or calculus indexes. The number of decayed, missing and filled teeth (DMFT&#xD;
      index) will be also assessed. The visual analogue scale (VAS) will be applied for the&#xD;
      assessment of pain after probing after the probing recording. Patients will receive a&#xD;
      clinical evaluation for halitosis using a Halimeter® to verify the concentration of the&#xD;
      volatile sulfur compounds (before and after periodontal treatment). Main psychiatric&#xD;
      assessment: Structured Clinical Interview (SCID) for DSM-IV-TR adapted for DSM-5, the&#xD;
      Liebowitz Social Anxiety (LSAs). Duration and frequency: after the initial clinical&#xD;
      assessment (dental and psychiatric) patients will be randomized into three groups. Two groups&#xD;
      (experimental- social phobia with no psychiatric treatment and control) will receive&#xD;
      periodontal treatment after the initial psychiatric evaluation. One group will receive&#xD;
      periodontal treatment after the improvement of psychiatric condition (3 months after the&#xD;
      initial assessment). The non-surgical periodontal treatment will be performed preferably&#xD;
      within 24 h. Patients will be reevaluated 3 and 6 months after the end of nonsurgical&#xD;
      periodontal treatment.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Not yet recruiting</last_known_status>
  <start_date type="Anticipated">October 5, 2017</start_date>
  <completion_date type="Anticipated">October 5, 2019</completion_date>
  <primary_completion_date type="Anticipated">May 5, 2019</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>Non surgical periodontal treatment</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Probing depth</measure>
    <time_frame>Change from baseline at 6 months</time_frame>
    <description>the distance from the clinical gingival margin to probe tip</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Clinical attachment level</measure>
    <time_frame>Change from baseline at 6 months</time_frame>
    <description>The distance from cementoenamel junction to probe tip</description>
  </secondary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Anticipated">45</enrollment>
  <condition>Social Phobia</condition>
  <condition>Periodontal Diseases</condition>
  <arm_group>
    <arm_group_label>Social phobia</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Patients with social phobia with no psychiatric treatment Intervention- non surgical periodontal treatment</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Social phobia under Psych T</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Patients with social phobia under psychiatric treatment (Psych T) Intervention- non surgical periodontal treatment</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Controls</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Patients without social phobia Intervention- non surgical periodontal treatment</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Non surgical periodontal treatment</intervention_name>
    <description>Scaling and root planning that will be performed with manual curettes or ultrasonic instruments</description>
    <arm_group_label>Controls</arm_group_label>
    <arm_group_label>Social phobia</arm_group_label>
    <arm_group_label>Social phobia under Psych T</arm_group_label>
    <other_name>scaling and root planning</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Diagnosis of Social Phobia according to the DSM-IV TR adapted for the DSM-5&#xD;
&#xD;
          -  Patients with cut-off score of 4 (moderately ill) in the Global Clinical Impression&#xD;
             (GCI) rating scale&#xD;
&#xD;
          -  Informed consent signature&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Patients with severe major depressive disorder at risk for suicide; substance abuse or&#xD;
             dependence, psychotic disorders or psychotherapy treatment&#xD;
&#xD;
          -  Patients in psychotherapy treatment&#xD;
&#xD;
          -  Systemic alteration that precludes periodontal clinical examination&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>35 Years</minimum_age>
    <maximum_age>65 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Francisco Lotufo-Neto, PhD</last_name>
    <role>Study Chair</role>
    <affiliation>Faculdade de Medicina FMUSP, Universidade de Sao Paulo, SP, Sao Paulo, SP, BR</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Ana Cristina Solis, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Faculdade de Medicina FMUSP, Universidade de Sao Paulo, SP, Sao Paulo, SP, BR</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Francisco Lotufo-Neto, PhD</last_name>
    <phone>+55-11-2661-6988</phone>
    <email>franciscolotufo@gmail.com</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Ana Cristina Solis, PhD</last_name>
    <phone>+55-11-2661-6988</phone>
    <email>anacristinasolis@hotmail.com</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Department and Institute of Psychiatry - FMUSP</name>
      <address>
        <city>São Paulo</city>
        <state>Sao Paulo</state>
        <zip>05403-903</zip>
        <country>Brazil</country>
      </address>
    </facility>
    <contact>
      <last_name>Francisco Lotufo-Neto, PhD</last_name>
      <phone>(011) 2661-6988</phone>
      <email>franciscolotufo@gmail.com</email>
    </contact>
    <contact_backup>
      <last_name>Ana Cristina Solis, PhD</last_name>
      <phone>(011) 2661-6988</phone>
      <email>anacristinasolis@hotmail.com</email>
    </contact_backup>
  </location>
  <location_countries>
    <country>Brazil</country>
  </location_countries>
  <results_reference>
    <citation>Albandar JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Periodontol. 1999 Jan;70(1):13-29. doi: 10.1902/jop.1999.70.1.13. Erratum In: J Periodontol 1999 Mar;70(3):351.</citation>
    <PMID>10052767</PMID>
  </results_reference>
  <results_reference>
    <citation>Andrade LH, Wang YP, Andreoni S, Silveira CM, Alexandrino-Silva C, Siu ER, Nishimura R, Anthony JC, Gattaz WF, Kessler RC, Viana MC. Mental disorders in megacities: findings from the Sao Paulo megacity mental health survey, Brazil. PLoS One. 2012;7(2):e31879. doi: 10.1371/journal.pone.0031879. Epub 2012 Feb 14.</citation>
    <PMID>22348135</PMID>
  </results_reference>
  <results_reference>
    <citation>Armfield JM, Slade GD, Spencer AJ. Dental fear and adult oral health in Australia. Community Dent Oral Epidemiol. 2009 Jun;37(3):220-30. doi: 10.1111/j.1600-0528.2009.00468.x.</citation>
    <PMID>19508270</PMID>
  </results_reference>
  <results_reference>
    <citation>Bakri I, Douglas CW, Rawlinson A. The effects of stress on periodontal treatment: a longitudinal investigation using clinical and biological markers. J Clin Periodontol. 2013 Oct;40(10):955-61. doi: 10.1111/jcpe.12142. Epub 2013 Aug 18.</citation>
    <PMID>23952266</PMID>
  </results_reference>
  <results_reference>
    <citation>Chung DT, Bogle G, Bernardini M, Stephens D, Riggs ML, Egelberg JH. Pain experienced by patients during periodontal maintenance. J Periodontol. 2003 Sep;74(9):1293-301. doi: 10.1902/jop.2003.74.9.1293.</citation>
    <PMID>14584861</PMID>
  </results_reference>
  <results_reference>
    <citation>Claffey N, Polyzois I, Ziaka P. An overview of nonsurgical and surgical therapy. Periodontol 2000. 2004;36:35-44. doi: 10.1111/j.1600-0757.2004.00073.x. No abstract available.</citation>
    <PMID>15330942</PMID>
  </results_reference>
  <results_reference>
    <citation>Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ; CDC Periodontal Disease Surveillance workgroup: James Beck (University of North Carolina, Chapel Hill, USA), Gordon Douglass (Past President, American Academy of Periodontology), Roy Page (University of Washin. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012 Oct;91(10):914-20. doi: 10.1177/0022034512457373. Epub 2012 Aug 30.</citation>
    <PMID>22935673</PMID>
  </results_reference>
  <results_reference>
    <citation>Eke PI, Page RC, Wei L, Thornton-Evans G, Genco RJ. Update of the case definitions for population-based surveillance of periodontitis. J Periodontol. 2012 Dec;83(12):1449-54. doi: 10.1902/jop.2012.110664. Epub 2012 Mar 16.</citation>
    <PMID>22420873</PMID>
  </results_reference>
  <results_reference>
    <citation>Erovic Ademovski S, Martensson C, Persson GR, Renvert S. The effect of periodontal therapy on intra-oral halitosis: a case series. J Clin Periodontol. 2016 May;43(5):445-452. doi: 10.1111/jcpe.12525. Epub 2016 Apr 18.</citation>
    <PMID>26847598</PMID>
  </results_reference>
  <results_reference>
    <citation>Fardal O, Hansen BF. Interviewing self-reported highly anxious patients during periodontal treatment. J Periodontol. 2007 Jun;78(6):1037-42. doi: 10.1902/jop.2007.060407.</citation>
    <PMID>17539717</PMID>
  </results_reference>
  <results_reference>
    <citation>Heitz-Mayfield LJ, Lang NP. Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts. Periodontol 2000. 2013 Jun;62(1):218-31. doi: 10.1111/prd.12008.</citation>
    <PMID>23574468</PMID>
  </results_reference>
  <results_reference>
    <citation>Khambaty T, Stewart JC. Associations of depressive and anxiety disorders with periodontal disease prevalence in young adults: analysis of 1999-2004 National Health and Nutrition Examination Survey (NHANES) data. Ann Behav Med. 2013 Jun;45(3):393-7. doi: 10.1007/s12160-013-9471-0.</citation>
    <PMID>23389686</PMID>
  </results_reference>
  <results_reference>
    <citation>Papapanou PN. The prevalence of periodontitis in the US: forget what you were told. J Dent Res. 2012 Oct;91(10):907-8. doi: 10.1177/0022034512458692. Epub 2012 Aug 30. No abstract available.</citation>
    <PMID>22935674</PMID>
  </results_reference>
  <results_reference>
    <citation>Santuchi CC, Cortelli SC, Cortelli JR, Cota LO, Alencar CO, Costa FO. Pre- and post-treatment experiences of fear, anxiety, and pain among chronic periodontitis patients treated by scaling and root planing per quadrant versus one-stage full-mouth disinfection: a 6-month randomized controlled clinical trial. J Clin Periodontol. 2015 Nov;42(11):1024-31. doi: 10.1111/jcpe.12472. Epub 2015 Nov 14.</citation>
    <PMID>26461465</PMID>
  </results_reference>
  <results_reference>
    <citation>Sheehan TJ. Creating a psychosocial measurement model from stressful life events. Soc Sci Med. 1996 Jul;43(2):265-71. doi: 10.1016/0277-9536(95)00377-0.</citation>
    <PMID>8844930</PMID>
  </results_reference>
  <results_reference>
    <citation>Suhas S, Sudarshan S, Pai KM. &quot;Air bag&quot; organoleptic behavioral experiment for managing fear of oral malodor. J Behav Ther Exp Psychiatry. 2004 Mar;35(1):13-5. doi: 10.1016/j.jbtep.2004.01.001.</citation>
    <PMID>15157814</PMID>
  </results_reference>
  <results_reference>
    <citation>Susin C, Valle P, Oppermann RV, Haugejorden O, Albandar JM. Occurrence and risk indicators of increased probing depth in an adult Brazilian population. J Clin Periodontol. 2005 Feb;32(2):123-9. doi: 10.1111/j.1600-051X.2005.00637.x.</citation>
    <PMID>15691340</PMID>
  </results_reference>
  <results_reference>
    <citation>Susin C, Haas AN, Oppermann RV, Haugejorden O, Albandar JM. Gingival recession: epidemiology and risk indicators in a representative urban Brazilian population. J Periodontol. 2004 Oct;75(10):1377-86. doi: 10.1902/jop.2004.75.10.1377.</citation>
    <PMID>15562916</PMID>
  </results_reference>
  <results_reference>
    <citation>Susin C, Dalla Vecchia CF, Oppermann RV, Haugejorden O, Albandar JM. Periodontal attachment loss in an urban population of Brazilian adults: effect of demographic, behavioral, and environmental risk indicators. J Periodontol. 2004 Jul;75(7):1033-41. doi: 10.1902/jop.2004.75.7.1033.</citation>
    <PMID>15341364</PMID>
  </results_reference>
  <results_reference>
    <citation>Vettore M, Quintanilha RS, Monteiro da Silva AM, Lamarca GA, Leao AT. The influence of stress and anxiety on the response of non-surgical periodontal treatment. J Clin Periodontol. 2005 Dec;32(12):1226-35. doi: 10.1111/j.1600-051X.2005.00852.x.</citation>
    <PMID>16268999</PMID>
  </results_reference>
  <results_reference>
    <citation>Winkel EG, Roldan S, Van Winkelhoff AJ, Herrera D, Sanz M. Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study. J Clin Periodontol. 2003 Apr;30(4):300-6. doi: 10.1034/j.1600-051x.2003.00342.x.</citation>
    <PMID>12694427</PMID>
  </results_reference>
  <results_reference>
    <citation>de Oliveira Solis AC, Araujo AC, Corchs F, Bernik M, Duran EP, Silva C, Lotufo-Neto F. Impact of post-traumatic stress disorder on oral health. J Affect Disord. 2017 Sep;219:126-132. doi: 10.1016/j.jad.2017.05.033. Epub 2017 May 20.</citation>
    <PMID>28549330</PMID>
  </results_reference>
  <results_reference>
    <citation>Liebowitz MR. Social phobia. Mod Probl Pharmacopsychiatry. 1987;22:141-73. doi: 10.1159/000414022. No abstract available.</citation>
    <PMID>2885745</PMID>
  </results_reference>
  <results_reference>
    <citation>Lima MS, Soares BG, Paoliello G, Machado Vieira R, Martins CM, Mota Neto JI, Ferrao Y, Schirmer DA, Volpe FM. The Portuguese version of the Clinical Global Impression-Schizophrenia Scale: validation study. Braz J Psychiatry. 2007 Sep;29(3):246-9. doi: 10.1590/s1516-44462007000300010.</citation>
    <PMID>17891261</PMID>
  </results_reference>
  <verification_date>July 2017</verification_date>
  <study_first_submitted>July 27, 2017</study_first_submitted>
  <study_first_submitted_qc>August 4, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">August 7, 2017</study_first_posted>
  <last_update_submitted>August 4, 2017</last_update_submitted>
  <last_update_submitted_qc>August 4, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">August 7, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>social phobia</keyword>
  <keyword>anxiety disorders</keyword>
  <keyword>DSM-IV TR</keyword>
  <keyword>periodontal disease</keyword>
  <keyword>non surgical periodontal treatment</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Periodontal Diseases</mesh_term>
    <mesh_term>Phobic Disorders</mesh_term>
    <mesh_term>Phobia, Social</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03241277
org study id: 33267314.9.0000.0068
secondary id: 821.780
nct id: NCT03241277
lead sponsor: 
collaborator: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
Objective: To investigate the impact of nonsurgical periodontal treatment in patients with
      social anxiety disorder (SAD) and controls without phobia.
Study design: randomized controlled trial. Setting: Institute of Psychiatry from FMUSP
      (Ipq-FMUSP). Subjects: patients seeking for Social Phobia treatment at IPq-FMUSP ( before and
      under treatment). Controls: Hospital staff at the HC-FMUSP or volunteers from a list of other
      studies conducted at the Ipq-FMUSP. Methods: Dental evaluation: probing depth, clinical
      attachment level and bleeding on probing will be recorded at 6 sites per tooth, as well as
      the plaque and/or calculus indexes. The number of decayed, missing and filled teeth (DMFT
      index) will be also assessed. The visual analogue scale (VAS) will be applied for the
      assessment of pain after probing after the probing recording. Patients will receive a
      clinical evaluation for halitosis using a Halimeter® to verify the concentration of the
      volatile sulfur compounds (before and after periodontal treatment). Main psychiatric
      assessment: Structured Clinical Interview (SCID) for DSM-IV-TR adapted for DSM-5, the
      Liebowitz Social Anxiety (LSAs). Duration and frequency: after the initial clinical
      assessment (dental and psychiatric) patients will be randomized into three groups. Two groups
      (experimental- social phobia with no psychiatric treatment and control) will receive
      periodontal treatment after the initial psychiatric evaluation. One group will receive
      periodontal treatment after the improvement of psychiatric condition (3 months after the
      initial assessment). The non-surgical periodontal treatment will be performed preferably
      within 24 h. Patients will be reevaluated 3 and 6 months after the end of nonsurgical
      periodontal treatment.
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: Non surgical periodontal treatment
primary purpose: Treatment
masking: None (Open Label)
measure: Probing depth
time frame: Change from baseline at 6 months
description: the distance from the clinical gingival margin to probe tip
measure: Clinical attachment level
time frame: Change from baseline at 6 months
description: The distance from cementoenamel junction to probe tip
arm group label: Social phobia
arm group type: Experimental
description: Patients with social phobia with no psychiatric treatment Intervention- non surgical periodontal treatment
arm group label: Social phobia under Psych T
arm group type: Experimental
description: Patients with social phobia under psychiatric treatment (Psych T) Intervention- non surgical periodontal treatment
arm group label: Controls
arm group type: Active Comparator
description: Patients without social phobia Intervention- non surgical periodontal treatment
intervention type: Procedure
intervention name: Non surgical periodontal treatment
description: Scaling and root planning that will be performed with manual curettes or ultrasonic instruments
arm group label: Controls
arm group label: Social phobia
arm group label: Social phobia under Psych T
other name: scaling and root planning
criteria: 
gender: All
minimum age: 35 Years
maximum age: 65 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Francisco Lotufo-Neto, PhD
role: Study Chair
affiliation: Faculdade de Medicina FMUSP, Universidade de Sao Paulo, SP, Sao Paulo, SP, BR
last name: Ana Cristina Solis, PhD
role: Principal Investigator
affiliation: Faculdade de Medicina FMUSP, Universidade de Sao Paulo, SP, Sao Paulo, SP, BR
last name: Francisco Lotufo-Neto, PhD
phone: +55-11-2661-6988
email: franciscolotufo@gmail.com
last name: Ana Cristina Solis, PhD
phone: +55-11-2661-6988
email: anacristinasolis@hotmail.com
facility: 
contact: 
contact backup: 
country: Brazil
citation: Albandar JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Periodontol. 1999 Jan;70(1):13-29. doi: 10.1902/jop.1999.70.1.13. Erratum In: J Periodontol 1999 Mar;70(3):351.
PMID: 10052767
citation: Andrade LH, Wang YP, Andreoni S, Silveira CM, Alexandrino-Silva C, Siu ER, Nishimura R, Anthony JC, Gattaz WF, Kessler RC, Viana MC. Mental disorders in megacities: findings from the Sao Paulo megacity mental health survey, Brazil. PLoS One. 2012;7(2):e31879. doi: 10.1371/journal.pone.0031879. Epub 2012 Feb 14.
PMID: 22348135
citation: Armfield JM, Slade GD, Spencer AJ. Dental fear and adult oral health in Australia. Community Dent Oral Epidemiol. 2009 Jun;37(3):220-30. doi: 10.1111/j.1600-0528.2009.00468.x.
PMID: 19508270
citation: Bakri I, Douglas CW, Rawlinson A. The effects of stress on periodontal treatment: a longitudinal investigation using clinical and biological markers. J Clin Periodontol. 2013 Oct;40(10):955-61. doi: 10.1111/jcpe.12142. Epub 2013 Aug 18.
PMID: 23952266
citation: Chung DT, Bogle G, Bernardini M, Stephens D, Riggs ML, Egelberg JH. Pain experienced by patients during periodontal maintenance. J Periodontol. 2003 Sep;74(9):1293-301. doi: 10.1902/jop.2003.74.9.1293.
PMID: 14584861
citation: Claffey N, Polyzois I, Ziaka P. An overview of nonsurgical and surgical therapy. Periodontol 2000. 2004;36:35-44. doi: 10.1111/j.1600-0757.2004.00073.x. No abstract available.
PMID: 15330942
citation: Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ; CDC Periodontal Disease Surveillance workgroup: James Beck (University of North Carolina, Chapel Hill, USA), Gordon Douglass (Past President, American Academy of Periodontology), Roy Page (University of Washin. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012 Oct;91(10):914-20. doi: 10.1177/0022034512457373. Epub 2012 Aug 30.
PMID: 22935673
citation: Eke PI, Page RC, Wei L, Thornton-Evans G, Genco RJ. Update of the case definitions for population-based surveillance of periodontitis. J Periodontol. 2012 Dec;83(12):1449-54. doi: 10.1902/jop.2012.110664. Epub 2012 Mar 16.
PMID: 22420873
citation: Erovic Ademovski S, Martensson C, Persson GR, Renvert S. The effect of periodontal therapy on intra-oral halitosis: a case series. J Clin Periodontol. 2016 May;43(5):445-452. doi: 10.1111/jcpe.12525. Epub 2016 Apr 18.
PMID: 26847598
citation: Fardal O, Hansen BF. Interviewing self-reported highly anxious patients during periodontal treatment. J Periodontol. 2007 Jun;78(6):1037-42. doi: 10.1902/jop.2007.060407.
PMID: 17539717
citation: Heitz-Mayfield LJ, Lang NP. Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts. Periodontol 2000. 2013 Jun;62(1):218-31. doi: 10.1111/prd.12008.
PMID: 23574468
citation: Khambaty T, Stewart JC. Associations of depressive and anxiety disorders with periodontal disease prevalence in young adults: analysis of 1999-2004 National Health and Nutrition Examination Survey (NHANES) data. Ann Behav Med. 2013 Jun;45(3):393-7. doi: 10.1007/s12160-013-9471-0.
PMID: 23389686
citation: Papapanou PN. The prevalence of periodontitis in the US: forget what you were told. J Dent Res. 2012 Oct;91(10):907-8. doi: 10.1177/0022034512458692. Epub 2012 Aug 30. No abstract available.
PMID: 22935674
citation: Santuchi CC, Cortelli SC, Cortelli JR, Cota LO, Alencar CO, Costa FO. Pre- and post-treatment experiences of fear, anxiety, and pain among chronic periodontitis patients treated by scaling and root planing per quadrant versus one-stage full-mouth disinfection: a 6-month randomized controlled clinical trial. J Clin Periodontol. 2015 Nov;42(11):1024-31. doi: 10.1111/jcpe.12472. Epub 2015 Nov 14.
PMID: 26461465
citation: Sheehan TJ. Creating a psychosocial measurement model from stressful life events. Soc Sci Med. 1996 Jul;43(2):265-71. doi: 10.1016/0277-9536(95)00377-0.
PMID: 8844930
citation: Suhas S, Sudarshan S, Pai KM. "Air bag" organoleptic behavioral experiment for managing fear of oral malodor. J Behav Ther Exp Psychiatry. 2004 Mar;35(1):13-5. doi: 10.1016/j.jbtep.2004.01.001.
PMID: 15157814
citation: Susin C, Valle P, Oppermann RV, Haugejorden O, Albandar JM. Occurrence and risk indicators of increased probing depth in an adult Brazilian population. J Clin Periodontol. 2005 Feb;32(2):123-9. doi: 10.1111/j.1600-051X.2005.00637.x.
PMID: 15691340
citation: Susin C, Haas AN, Oppermann RV, Haugejorden O, Albandar JM. Gingival recession: epidemiology and risk indicators in a representative urban Brazilian population. J Periodontol. 2004 Oct;75(10):1377-86. doi: 10.1902/jop.2004.75.10.1377.
PMID: 15562916
citation: Susin C, Dalla Vecchia CF, Oppermann RV, Haugejorden O, Albandar JM. Periodontal attachment loss in an urban population of Brazilian adults: effect of demographic, behavioral, and environmental risk indicators. J Periodontol. 2004 Jul;75(7):1033-41. doi: 10.1902/jop.2004.75.7.1033.
PMID: 15341364
citation: Vettore M, Quintanilha RS, Monteiro da Silva AM, Lamarca GA, Leao AT. The influence of stress and anxiety on the response of non-surgical periodontal treatment. J Clin Periodontol. 2005 Dec;32(12):1226-35. doi: 10.1111/j.1600-051X.2005.00852.x.
PMID: 16268999
citation: Winkel EG, Roldan S, Van Winkelhoff AJ, Herrera D, Sanz M. Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study. J Clin Periodontol. 2003 Apr;30(4):300-6. doi: 10.1034/j.1600-051x.2003.00342.x.
PMID: 12694427
citation: de Oliveira Solis AC, Araujo AC, Corchs F, Bernik M, Duran EP, Silva C, Lotufo-Neto F. Impact of post-traumatic stress disorder on oral health. J Affect Disord. 2017 Sep;219:126-132. doi: 10.1016/j.jad.2017.05.033. Epub 2017 May 20.
PMID: 28549330
citation: Liebowitz MR. Social phobia. Mod Probl Pharmacopsychiatry. 1987;22:141-73. doi: 10.1159/000414022. No abstract available.
PMID: 2885745
citation: Lima MS, Soares BG, Paoliello G, Machado Vieira R, Martins CM, Mota Neto JI, Ferrao Y, Schirmer DA, Volpe FM. The Portuguese version of the Clinical Global Impression-Schizophrenia Scale: validation study. Braz J Psychiatry. 2007 Sep;29(3):246-9. doi: 10.1590/s1516-44462007000300010.
PMID: 17891261
responsible party type: Sponsor
mesh term: Periodontal Diseases
mesh term: Phobic Disorders
mesh term: Phobia, Social