<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03261141</url>
  </required_header>
  <id_info>
    <org_study_id>PV-RQOL in Dysphonic children</org_study_id>
    <nct_id>NCT03261141</nct_id>
  </id_info>
  <brief_title>Correlation Between (PV-RQOL), The Auditory Perceptual Assessment and Acoustic Analysis of Voice in Dysphonic Children</brief_title>
  <official_title>Correlation Between The Arabic Pediatric Voice Related Quality of Life (PV-RQOL), The Auditory Perceptual Assessment and Acoustic Analysis of Voice in Dysphonic Children</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Assiut University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Assiut University</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The aim of this study is to assess the Correlation between The Arabic Pediatric Voice Related&#xD;
      Quality of Life (PV-RQOL), The Auditory Perceptual Assessment and Acoustic Analysis of voice&#xD;
      of dysphonic children. This is important to provide an efficient therapeutic strategy for&#xD;
      these children.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Voice is the carrier wave for speech signal. It can also be defined as an audible sound&#xD;
      produced by phonation . It is a primary mean of expression and oral communication and has&#xD;
      life-long importance to social well-being.&#xD;
&#xD;
      Through life, voice development follows and represents organic, psychological, and social&#xD;
      changes in the person .&#xD;
&#xD;
      Any disruption of the function of voice is called dysphonia . defination of dysphonia is&#xD;
      perceptual audible change of a patient's habitual voice as self-judged or judged by his or&#xD;
      her listeners.&#xD;
&#xD;
      The incidence of the pediatric voice disorders ranges from 6%-23%, while, stated that voice&#xD;
      disorders affect approximately 6-9% of pediatric population. Boys were statistically more&#xD;
      likely to have dysphonia (7.5%) over girls (4.6%) , abnormal vocal presentations&#xD;
      (symptomatology) include: phonasthenia ,dysphonia, aphonia and dysodia. Dysphonia may&#xD;
      adversely impact a child's general health, communicative effectiveness, social and&#xD;
      educational development, self-esteem, and participation in school group activities. Hence,&#xD;
      dysphonia has a substantial negative effect on children's lives.Although voice disorders are&#xD;
      common in the pediatric population; there is still a lack of information available to&#xD;
      clinicians regarding evaluation and treatment of pediatric voice disorders.&#xD;
&#xD;
      Etiology of Voice disorders can be subdivided into 3 main groups: There are the organic voice&#xD;
      disorders (There are detectable morphological changes in the vocal apparatus), Non-organic&#xD;
      (functional) voice disorders (There is no detectable organic pathology in the structure of&#xD;
      the larynx) and Minimal Associated Pathological Lesions (MAPLs) (Long-standing, non-organic&#xD;
      (functional) voice disorders leading to the creation of detectable organic changes.&#xD;
&#xD;
      The protocol of evaluation of voice disorders is constructed /built in escalating stepwise&#xD;
      stages from the simple subjective bed-side diagnostic procedures to the more sophisticated&#xD;
      objective quantitative instrumental measures. Thus the protocol encompasses the following 3&#xD;
      levels which are 1- Elementary diagnostic procedures, 2-Clinical diagnostic aids 3-Additional&#xD;
      instrumental measures .&#xD;
&#xD;
      Several instruments have been designed specifically to evaluate quality of life outcomes in&#xD;
      dysphonic populations. The best validated and most utilized surveys are the Voice Handicap&#xD;
      Index (VHI) , the Voice Outcome Survey (VOS) and the Voice-Related Quality of Life (V-RQoL) .&#xD;
      These instruments were designed to be used in the assessment of dysphonic patients and were&#xD;
      validated in adult populations. Since their dissemination, each of these instruments have&#xD;
      produced a pediatric analogue, namely a pediatric VOS (PVOS) , a pediatric V-RQoL and a&#xD;
      pediatric VHI (PVHI).&#xD;
&#xD;
      Questionnaire may help to increase the patient's awareness of the impact of dysphonia and his&#xD;
      motivation for change. The Questionnaires have also been proven sensitive to post-changes and&#xD;
      are an additional and valuable tool in the determination of therapy efficiency.&#xD;
&#xD;
      At Minia University, a study was carried out to develop an Arabic version of PVRQoL and test&#xD;
      its validity and reliability .The results suggested that the APVRQoL is a valid and reliable&#xD;
      assessment tool that can be used by the parents of Arabic-speaking children or by the&#xD;
      children themselves (when they are older) with voice disorders to assess the impact of&#xD;
      dysphonia on the quality of their lives.&#xD;
&#xD;
      The (PV-RQOL) has 10 questions that are divided among 4 subdomains: The social (questions no:&#xD;
      8 and 10), emotional (questions no: 4 and 5) , The physical (questions no: 2 and 3) and the&#xD;
      functional (questions no: 1, 6,7 and 9), each question is rated from 1to5 (1=no problem and&#xD;
      is given&quot;10 points&quot;,2=a small amount and is given&quot;7.5points&quot;,3=a moderate amount and is&#xD;
      given&quot;5 points&quot;,4=a lot and is given&quot;2.5 points&quot;, and 5=problem is as bad as it can be, and&#xD;
      is given&quot;0 points&quot;. Thus the raw scores can range from 0 to 100 points with higher scores&#xD;
      indicating a better quality of life.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Not yet recruiting</last_known_status>
  <start_date type="Anticipated">November 1, 2017</start_date>
  <completion_date type="Anticipated">October 2018</completion_date>
  <primary_completion_date type="Anticipated">September 2018</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Control</observational_model>
    <time_perspective>Cross-Sectional</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>All participants' scores of (PV-RQOL) questionnaire will be correlated with scores of auditory perceptual assessment and Acoustic voice analysis.</measure>
    <time_frame>baseline</time_frame>
    <description>Application of the Arabic Pediatric Voice Related Quality of Life (PV-RQOL): all participants /parents of the participants will be given (PV-RQOL) form that consists of 10 questions divided among 4 subdomains: The social (questions no: 8 and 10), emotional (questions no: 4 and 5) , The physical (questions no: 2 and 3) and the functional (questions no: 1, 6,7 and 9) . Thus the total score can range from 0 to 100 points with higher scores indicating a better quality of life.and Auditory perceptual assessment (APA) of the participant's voice: the domains will be graded on a scale of 0-3, in which 0 is normal and 3 is severe.and Acoustic voice analysis: will be carried out using Kay Elemetrics' Computerized Speech Laboratory. These measures will be obtained by recording the voice of each participant using a microphone positioned ∼10 cm from his/her mouth and the participantswill be asked to phonate a sustained vowel /a/ at comfortable pitch and intensity levels.</description>
  </primary_outcome>
  <number_of_groups>2</number_of_groups>
  <enrollment type="Anticipated">126</enrollment>
  <condition>Dysphonia</condition>
  <arm_group>
    <arm_group_label>study group sixty three children</arm_group_label>
    <description>severity and character of dysphonia APA using a modified GRBAS scale which gives scores as regard the degree and severity of dysphonia and its character.&#xD;
Acoustic Analysis of voice : which is Computerized Speech Laboratory analysis of voice that gives the following measures jitter (%), shimmer (dB), and harmonic to noise ratio (H/N).&#xD;
the degree of social ,emotional ,functional and physical disturbance ,if present in those children with voice disorders by application of The Arabic Pediatric Voice Related Quality of Life (PV-RQOL).</description>
  </arm_group>
  <arm_group>
    <arm_group_label>control group sixty three children</arm_group_label>
    <description>severity and character of dysphonia (APA using a modified GRBAS scale which gives scores as regard the degree and severity of dysphonia and its character.&#xD;
Acoustic Analysis of voice : which is Computerized Speech Laboratory analysis of voice that gives the following measures jitter (%), shimmer (dB), and harmonic to noise ratio (H/N).&#xD;
the degree of social ,emotional ,functional and physical disturbance ,if present in those children with voice disorders by application of The Arabic Pediatric Voice Related Quality of Life (PV-RQOL).</description>
  </arm_group>
  <intervention>
    <intervention_type>Combination Product</intervention_type>
    <intervention_name>(PV-RQOL),(APA) ,Acoustic analysis</intervention_name>
    <description>severity and character of dysphonia (measured by Auditory Perceptual Assessment using a modified GRBAS scale which gives scores as regard the degree and severity of dysphonia and its character.&#xD;
Acoustic Analysis of voice : which is Computerized Speech Laboratory analysis of voice that gives the following measures jitter (%), shimmer (dB), and harmonic to noise ratio (H/N).&#xD;
the degree of social ,emotional ,functional and physical disturbance ,if present in those children with voice disorders by application of The Arabic Pediatric Voice Related Quality of Life (PV-RQOL).</description>
    <arm_group_label>control group sixty three children</arm_group_label>
    <arm_group_label>study group sixty three children</arm_group_label>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        One hundred twenty six (126) children will participate in the study; in 2 groups ,1-study&#xD;
        group 63 children they have dysphonia due to functional (non-organic) causes or due to&#xD;
        Minimal Associated Pathological Lesions (MAPLs),2-control group 63 children without vocal&#xD;
        complaints They will be recruited from the outpatient clinic of Phoniatric Unit, Assiut&#xD;
        University Hospital.&#xD;
&#xD;
        Participants (whether their caretakers or themselves) will sign an informed consent of&#xD;
        approval to participate in the study after explanation of the study procedures.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
        -clinical diagnosis of change of voice due to functional (non-organic) causes or due to&#xD;
        Minimal Associated Pathological Lesions (MAPLs).&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Mental Retardation.&#xD;
&#xD;
          -  chronic illnesses affecting their quality of lives.&#xD;
&#xD;
          -  organic voice disorders.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>6 Years</minimum_age>
    <maximum_age>18 Years</maximum_age>
  </eligibility>
  <overall_contact>
    <last_name>Asmaa Fathy, resident</last_name>
    <phone>01149852648</phone>
    <email>asmaafathy254@yahoo.com</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Eman Sayed, prof.dr</last_name>
    <phone>01004082014</phone>
    <email>eshh2003@aun.edu.eg</email>
  </overall_contact_backup>
  <reference>
    <citation>Lopes LW, Barbosa Lima IL, Alves Almeida LN, Cavalcante DP, de Almeida AA. Severity of voice disorders in children: correlations between perceptual and acoustic data. J Voice. 2012 Nov;26(6):819.e7-12. doi: 10.1016/j.jvoice.2012.05.008.</citation>
    <PMID>23177753</PMID>
  </reference>
  <reference>
    <citation>Kotby MN, Shiromoto O, Hirano M. The accent method of voice therapy: effect of accentuations on FO, SPL, and airflow. J Voice. 1993 Dec;7(4):319-25. doi: 10.1016/s0892-1997(05)80120-1.</citation>
    <PMID>8293064</PMID>
  </reference>
  <reference>
    <citation>Carding PN, Roulstone S, Northstone K; ALSPAC Study Team. The prevalence of childhood dysphonia: a cross-sectional study. J Voice. 2006 Dec;20(4):623-30. doi: 10.1016/j.jvoice.2005.07.004. Epub 2005 Dec 19.</citation>
    <PMID>16360302</PMID>
  </reference>
  <reference>
    <citation>Trani M, Ghidini A, Bergamini G, Presutti L. Voice therapy in pediatric functional dysphonia: a prospective study. Int J Pediatr Otorhinolaryngol. 2007 Mar;71(3):379-84. doi: 10.1016/j.ijporl.2006.11.002. Epub 2006 Nov 29.</citation>
    <PMID>17137639</PMID>
  </reference>
  <reference>
    <citation>Blumin JH, Keppel KL, Braun NM, Kerschner JE, Merati AL. The impact of gender and age on voice related quality of life in children: normative data. Int J Pediatr Otorhinolaryngol. 2008 Feb;72(2):229-34. doi: 10.1016/j.ijporl.2007.10.015. Epub 2007 Dec 11.</citation>
    <PMID>18063123</PMID>
  </reference>
  <reference>
    <citation>Connor NP, Cohen SB, Theis SM, Thibeault SL, Heatley DG, Bless DM. Attitudes of children with dysphonia. J Voice. 2008 Mar;22(2):197-209. doi: 10.1016/j.jvoice.2006.09.005. Epub 2007 May 18.</citation>
    <PMID>17512168</PMID>
  </reference>
  <reference>
    <citation>Gliklich RE, Glovsky RM, Montgomery WW. Validation of a voice outcome survey for unilateral vocal cord paralysis. Otolaryngol Head Neck Surg. 1999 Feb;120(2):153-8. doi: 10.1016/S0194-5998(99)70399-2.</citation>
    <PMID>9949345</PMID>
  </reference>
  <reference>
    <citation>Hartnick CJ. Validation of a pediatric voice quality-of-life instrument: the pediatric voice outcome survey. Arch Otolaryngol Head Neck Surg. 2002 Aug;128(8):919-22. doi: 10.1001/archotol.128.8.919.</citation>
    <PMID>12162771</PMID>
  </reference>
  <reference>
    <citation>Boseley ME, Cunningham MJ, Volk MS, Hartnick CJ. Validation of the Pediatric Voice-Related Quality-of-Life survey. Arch Otolaryngol Head Neck Surg. 2006 Jul;132(7):717-20. doi: 10.1001/archotol.132.7.717.</citation>
    <PMID>16847178</PMID>
  </reference>
  <reference>
    <citation>Zur KB, Cotton S, Kelchner L, Baker S, Weinrich B, Lee L. Pediatric Voice Handicap Index (pVHI): a new tool for evaluating pediatric dysphonia. Int J Pediatr Otorhinolaryngol. 2007 Jan;71(1):77-82. doi: 10.1016/j.ijporl.2006.09.004. Epub 2006 Oct 13.</citation>
    <PMID>17046072</PMID>
  </reference>
  <reference>
    <citation>Verduyckt I, Remacle M, Jamart J, Benderitter C, Morsomme D. Voice-related complaints in the pediatric population. J Voice. 2011 May;25(3):373-80. doi: 10.1016/j.jvoice.2009.11.008. Epub 2010 Apr 1.</citation>
    <PMID>20359863</PMID>
  </reference>
  <verification_date>August 2017</verification_date>
  <study_first_submitted>August 21, 2017</study_first_submitted>
  <study_first_submitted_qc>August 22, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">August 24, 2017</study_first_posted>
  <last_update_submitted>October 23, 2017</last_update_submitted>
  <last_update_submitted_qc>October 23, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">October 24, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Assiut University</investigator_affiliation>
    <investigator_full_name>Asmaa Fathy</investigator_full_name>
    <investigator_title>principal investigator</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Dysphonia</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03261141
org study id: PV-RQOL in Dysphonic children
nct id: NCT03261141
lead sponsor: 
is fda regulated drug: No
is fda regulated device: No
The aim of this study is to assess the Correlation between The Arabic Pediatric Voice Related
      Quality of Life (PV-RQOL), The Auditory Perceptual Assessment and Acoustic Analysis of voice
      of dysphonic children. This is important to provide an efficient therapeutic strategy for
      these children.
Voice is the carrier wave for speech signal. It can also be defined as an audible sound
      produced by phonation . It is a primary mean of expression and oral communication and has
      life-long importance to social well-being.

      Through life, voice development follows and represents organic, psychological, and social
      changes in the person .

      Any disruption of the function of voice is called dysphonia . defination of dysphonia is
      perceptual audible change of a patient's habitual voice as self-judged or judged by his or
      her listeners.

      The incidence of the pediatric voice disorders ranges from 6%-23%, while, stated that voice
      disorders affect approximately 6-9% of pediatric population. Boys were statistically more
      likely to have dysphonia (7.5%) over girls (4.6%) , abnormal vocal presentations
      (symptomatology) include: phonasthenia ,dysphonia, aphonia and dysodia. Dysphonia may
      adversely impact a child's general health, communicative effectiveness, social and
      educational development, self-esteem, and participation in school group activities. Hence,
      dysphonia has a substantial negative effect on children's lives.Although voice disorders are
      common in the pediatric population; there is still a lack of information available to
      clinicians regarding evaluation and treatment of pediatric voice disorders.

      Etiology of Voice disorders can be subdivided into 3 main groups: There are the organic voice
      disorders (There are detectable morphological changes in the vocal apparatus), Non-organic
      (functional) voice disorders (There is no detectable organic pathology in the structure of
      the larynx) and Minimal Associated Pathological Lesions (MAPLs) (Long-standing, non-organic
      (functional) voice disorders leading to the creation of detectable organic changes.

      The protocol of evaluation of voice disorders is constructed /built in escalating stepwise
      stages from the simple subjective bed-side diagnostic procedures to the more sophisticated
      objective quantitative instrumental measures. Thus the protocol encompasses the following 3
      levels which are 1- Elementary diagnostic procedures, 2-Clinical diagnostic aids 3-Additional
      instrumental measures .

      Several instruments have been designed specifically to evaluate quality of life outcomes in
      dysphonic populations. The best validated and most utilized surveys are the Voice Handicap
      Index (VHI) , the Voice Outcome Survey (VOS) and the Voice-Related Quality of Life (V-RQoL) .
      These instruments were designed to be used in the assessment of dysphonic patients and were
      validated in adult populations. Since their dissemination, each of these instruments have
      produced a pediatric analogue, namely a pediatric VOS (PVOS) , a pediatric V-RQoL and a
      pediatric VHI (PVHI).

      Questionnaire may help to increase the patient's awareness of the impact of dysphonia and his
      motivation for change. The Questionnaires have also been proven sensitive to post-changes and
      are an additional and valuable tool in the determination of therapy efficiency.

      At Minia University, a study was carried out to develop an Arabic version of PVRQoL and test
      its validity and reliability .The results suggested that the APVRQoL is a valid and reliable
      assessment tool that can be used by the parents of Arabic-speaking children or by the
      children themselves (when they are older) with voice disorders to assess the impact of
      dysphonia on the quality of their lives.

      The (PV-RQOL) has 10 questions that are divided among 4 subdomains: The social (questions no:
      8 and 10), emotional (questions no: 4 and 5) , The physical (questions no: 2 and 3) and the
      functional (questions no: 1, 6,7 and 9), each question is rated from 1to5 (1=no problem and
      is given"10 points",2=a small amount and is given"7.5points",3=a moderate amount and is
      given"5 points",4=a lot and is given"2.5 points", and 5=problem is as bad as it can be, and
      is given"0 points". Thus the raw scores can range from 0 to 100 points with higher scores
      indicating a better quality of life.
observational model: Case-Control
time perspective: Cross-Sectional
measure: All participants' scores of (PV-RQOL) questionnaire will be correlated with scores of auditory perceptual assessment and Acoustic voice analysis.
time frame: baseline
description: Application of the Arabic Pediatric Voice Related Quality of Life (PV-RQOL): all participants /parents of the participants will be given (PV-RQOL) form that consists of 10 questions divided among 4 subdomains: The social (questions no: 8 and 10), emotional (questions no: 4 and 5) , The physical (questions no: 2 and 3) and the functional (questions no: 1, 6,7 and 9) . Thus the total score can range from 0 to 100 points with higher scores indicating a better quality of life.and Auditory perceptual assessment (APA) of the participant's voice: the domains will be graded on a scale of 0-3, in which 0 is normal and 3 is severe.and Acoustic voice analysis: will be carried out using Kay Elemetrics' Computerized Speech Laboratory. These measures will be obtained by recording the voice of each participant using a microphone positioned ∼10 cm from his/her mouth and the participantswill be asked to phonate a sustained vowel /a/ at comfortable pitch and intensity levels.
arm group label: study group sixty three children
description: severity and character of dysphonia APA using a modified GRBAS scale which gives scores as regard the degree and severity of dysphonia and its character.
Acoustic Analysis of voice : which is Computerized Speech Laboratory analysis of voice that gives the following measures jitter (%), shimmer (dB), and harmonic to noise ratio (H/N).
the degree of social ,emotional ,functional and physical disturbance ,if present in those children with voice disorders by application of The Arabic Pediatric Voice Related Quality of Life (PV-RQOL).
arm group label: control group sixty three children
description: severity and character of dysphonia (APA using a modified GRBAS scale which gives scores as regard the degree and severity of dysphonia and its character.
Acoustic Analysis of voice : which is Computerized Speech Laboratory analysis of voice that gives the following measures jitter (%), shimmer (dB), and harmonic to noise ratio (H/N).
the degree of social ,emotional ,functional and physical disturbance ,if present in those children with voice disorders by application of The Arabic Pediatric Voice Related Quality of Life (PV-RQOL).
intervention type: Combination Product
intervention name: (PV-RQOL),(APA) ,Acoustic analysis
description: severity and character of dysphonia (measured by Auditory Perceptual Assessment using a modified GRBAS scale which gives scores as regard the degree and severity of dysphonia and its character.
Acoustic Analysis of voice : which is Computerized Speech Laboratory analysis of voice that gives the following measures jitter (%), shimmer (dB), and harmonic to noise ratio (H/N).
the degree of social ,emotional ,functional and physical disturbance ,if present in those children with voice disorders by application of The Arabic Pediatric Voice Related Quality of Life (PV-RQOL).
arm group label: control group sixty three children
arm group label: study group sixty three children
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 6 Years
maximum age: 18 Years
last name: Asmaa Fathy, resident
phone: 01149852648
email: asmaafathy254@yahoo.com
last name: Eman Sayed, prof.dr
phone: 01004082014
email: eshh2003@aun.edu.eg
citation: Lopes LW, Barbosa Lima IL, Alves Almeida LN, Cavalcante DP, de Almeida AA. Severity of voice disorders in children: correlations between perceptual and acoustic data. J Voice. 2012 Nov;26(6):819.e7-12. doi: 10.1016/j.jvoice.2012.05.008.
PMID: 23177753
citation: Kotby MN, Shiromoto O, Hirano M. The accent method of voice therapy: effect of accentuations on FO, SPL, and airflow. J Voice. 1993 Dec;7(4):319-25. doi: 10.1016/s0892-1997(05)80120-1.
PMID: 8293064
citation: Carding PN, Roulstone S, Northstone K; ALSPAC Study Team. The prevalence of childhood dysphonia: a cross-sectional study. J Voice. 2006 Dec;20(4):623-30. doi: 10.1016/j.jvoice.2005.07.004. Epub 2005 Dec 19.
PMID: 16360302
citation: Trani M, Ghidini A, Bergamini G, Presutti L. Voice therapy in pediatric functional dysphonia: a prospective study. Int J Pediatr Otorhinolaryngol. 2007 Mar;71(3):379-84. doi: 10.1016/j.ijporl.2006.11.002. Epub 2006 Nov 29.
PMID: 17137639
citation: Blumin JH, Keppel KL, Braun NM, Kerschner JE, Merati AL. The impact of gender and age on voice related quality of life in children: normative data. Int J Pediatr Otorhinolaryngol. 2008 Feb;72(2):229-34. doi: 10.1016/j.ijporl.2007.10.015. Epub 2007 Dec 11.
PMID: 18063123
citation: Connor NP, Cohen SB, Theis SM, Thibeault SL, Heatley DG, Bless DM. Attitudes of children with dysphonia. J Voice. 2008 Mar;22(2):197-209. doi: 10.1016/j.jvoice.2006.09.005. Epub 2007 May 18.
PMID: 17512168
citation: Gliklich RE, Glovsky RM, Montgomery WW. Validation of a voice outcome survey for unilateral vocal cord paralysis. Otolaryngol Head Neck Surg. 1999 Feb;120(2):153-8. doi: 10.1016/S0194-5998(99)70399-2.
PMID: 9949345
citation: Hartnick CJ. Validation of a pediatric voice quality-of-life instrument: the pediatric voice outcome survey. Arch Otolaryngol Head Neck Surg. 2002 Aug;128(8):919-22. doi: 10.1001/archotol.128.8.919.
PMID: 12162771
citation: Boseley ME, Cunningham MJ, Volk MS, Hartnick CJ. Validation of the Pediatric Voice-Related Quality-of-Life survey. Arch Otolaryngol Head Neck Surg. 2006 Jul;132(7):717-20. doi: 10.1001/archotol.132.7.717.
PMID: 16847178
citation: Zur KB, Cotton S, Kelchner L, Baker S, Weinrich B, Lee L. Pediatric Voice Handicap Index (pVHI): a new tool for evaluating pediatric dysphonia. Int J Pediatr Otorhinolaryngol. 2007 Jan;71(1):77-82. doi: 10.1016/j.ijporl.2006.09.004. Epub 2006 Oct 13.
PMID: 17046072
citation: Verduyckt I, Remacle M, Jamart J, Benderitter C, Morsomme D. Voice-related complaints in the pediatric population. J Voice. 2011 May;25(3):373-80. doi: 10.1016/j.jvoice.2009.11.008. Epub 2010 Apr 1.
PMID: 20359863
responsible party type: Principal Investigator
investigator affiliation: Assiut University
investigator full name: Asmaa Fathy
investigator title: principal investigator
mesh term: Dysphonia