<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03258112</url>
  </required_header>
  <id_info>
    <org_study_id>electrophysiology</org_study_id>
    <nct_id>NCT03258112</nct_id>
  </id_info>
  <brief_title>Safety and Efficacy of Catheter Ablation of Idiopathic Ventricular Arrhythmias Arising From Cardiac Outflow Tracts</brief_title>
  <official_title>Safety and Efficacy of Catheter Ablation of Idiopathic Ventricular Arrhythmias Arising From Cardiac Outflow Tracts</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Assiut University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Assiut University</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Ventricular arrhythmias arising from cardiac outflow tract affect quality of life and can&#xD;
      cause decrease in left ventricular ejection fraction.&#xD;
&#xD;
      Drugs used for treating those arrhytmias may be ineffective or may have side effects.&#xD;
&#xD;
      Radiofrequency catheter ablation can be used safely for treatment of outflow tract&#xD;
      arrhythmias.&#xD;
&#xD;
      There are different sites where those ventricular arrhythmias may originates, each site has&#xD;
      different electrocardiographic characteristics, different procedural success rates and&#xD;
      challenges in localization and ablation.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The right and left ventricular outflow tracts (RVOT/LVOT) are the most common sites of origin&#xD;
      for idiopathic ventricular tachycardia (VT) and premature ventricular contractions (PVCs) in&#xD;
      patients without structural heart disease.1&#xD;
&#xD;
      Frequent PVCs was associated with PVC-induced cardiomyopathy, and radiofrequency (RF)&#xD;
      catheter ablation of frequent PVCs was associated with improvement of left ventricular&#xD;
      ejection fraction (LVEF).2&#xD;
&#xD;
      The most common underlying pathophysiological mechanism was identified to be triggered&#xD;
      activity and RF catheter ablation treatment is highly effective with low complication&#xD;
      rates.1,3 Drug therapy has limited effectiveness (in case β-blockers and calcium-channel&#xD;
      blockers) or drug-related side effects ( in case of flecainide, propafenone and amiodarone).4&#xD;
&#xD;
      RF catheter ablation is recommended in cases of high PVC burden associated with decreased LV&#xD;
      ejection fraction (LVEF) or in highly symptomatic patients despite optimal drug therapy.3&#xD;
&#xD;
      Although the RVOT is the most common site (about 70-80% of cases) for idiopathic VAs1,5, only&#xD;
      few studies have reported on the prevalence and RF catheter ablation of ventricular&#xD;
      arrhythmias (VAs) arising from the pulmonary artery (21-46% among the RVOT VAs)6 and even&#xD;
      less prevalence is reported in VAs arising from the pulmonary sinus cusps (11%).7&#xD;
&#xD;
      Compared with VAs originating from the RVOT, ablation of LVOT-VAs is more complex and&#xD;
      reported to be 12-45% of all idiopathic VAs.8-11 The success rate of ablation of LVOT-VA&#xD;
      sites was previously reported to be lower (55-60%) without using antegrade/transseptal&#xD;
      approaches.12,4 Rarely, it requires epicardial ablation via the GCV/AIV or subxiphoid&#xD;
      puncture.13,14&#xD;
&#xD;
      There are some cases in which RF catheter ablation cannot successfully be performed from&#xD;
      either LVOT or RVOT. In such cases the VAs may originate from the LV-summit which is the most&#xD;
      common site of idiopathic epicardial VAs from the LVOT region.13&#xD;
&#xD;
      Although most idiopathic VAs originating from the cardiac OTs are suitable targets for&#xD;
      endocardial RF catheter ablation, a small percentage of failures in these patients may be&#xD;
      because of an inaccessible site of origin from epicardial or intramural septal&#xD;
      locations.15The identification, mapping and RF catheter ablation of these idiopathic VAs may&#xD;
      be challenging for the electrophysiologist and need special consideration.16&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Withdrawn</overall_status>
  <why_stopped>
    I have changed my center and gone to another center&#xD;
  </why_stopped>
  <start_date type="Anticipated">March 2017</start_date>
  <completion_date type="Anticipated">November 2021</completion_date>
  <primary_completion_date type="Anticipated">April 2021</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>N/A</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>procedural success</measure>
    <time_frame>24 hours after the procedure</time_frame>
    <description>success of the procedure in ablation of ventricular arrhythmia with termination of ventricular arrhythmia, absence of induction of arrhythmia and 24 hours electrocardiographic monitoring after the procedure documenting absence of ventricular arrhythmia</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Recurrence of ventricular arrhythmia after three months</measure>
    <time_frame>Three months</time_frame>
    <description>Appearance of symptoms of palpitation and documentation of recurrence of same type of arrhythmia with prolonged electrocardiographic monitoring in case of symptoms</description>
  </secondary_outcome>
  <number_of_arms>1</number_of_arms>
  <enrollment type="Actual">0</enrollment>
  <condition>Ventricular Arrythmia</condition>
  <arm_group>
    <arm_group_label>catheter ablation</arm_group_label>
    <arm_group_type>Other</arm_group_type>
    <description>all patients indicated for catheter ablation of RVOT or LVOT ventricular arrhythmia are included in one arm for electrophysiological diagnosis of the origin of arrhythmia then for radiofrequency catheter ablation</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Radiofrequency cardiac catheter ablation</intervention_name>
    <description>procedure used for ablation of ventricular arrhythmia using catheters introduced to target sites percutaneously through venous or arterial systems using radiofrequency power</description>
    <arm_group_label>catheter ablation</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patients with idiopathic RVOT/LVOT ventricular arrhythmias in cases of Frequent (PVCs&#xD;
             =10.000/24hours), NSVT, or VT Symptomatic, Associated with LV dysfunction (no&#xD;
             explained with any cause other than VAs) or Resistance, patient intolerance or patient&#xD;
             refusal of drug therapy&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Presence of coronary artery disease, valvular heart disease or any other underlying&#xD;
             causes&#xD;
&#xD;
          -  arrhythmia not originating from cardiac outflow tracts&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>N/A</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Mohamed Abo Elhassan Abdel-Rady</last_name>
    <role>Principal Investigator</role>
    <affiliation>Assiut University</affiliation>
  </overall_official>
  <reference>
    <citation>Latchamsetty R, Yokokawa M, Morady F, Kim HM, Mathew S, Tilz R, et al. Multicenter outcomes for catheter ablation of idiopathic premature ventricular complexes. J Am Coll Cardiol EP 2015; 1: 116 - 123</citation>
  </reference>
  <reference>
    <citation>Kumagai K. Idiopathic ventricular arrhythmias arising from the left ventricular outflow tract: Tips and tricks. J Arrythmia 2014; 30: 211 - 221</citation>
  </reference>
  <results_reference>
    <citation>Priori SG, Blomstrom-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekval TM, Spaulding C, Van Veldhuisen DJ; ESC Scientific Document Group. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015 Nov 1;36(41):2793-2867. doi: 10.1093/eurheartj/ehv316. Epub 2015 Aug 29. No abstract available.</citation>
    <PMID>26320108</PMID>
  </results_reference>
  <results_reference>
    <citation>Wojdyla-Hordynska A, Kowalski O, Hordynski GJ, Dinov B, Sommer P, Hindricks G, Feusette P, Arya A. The effect of radiofrequency catheter ablation of frequent premature ventricular complexes and arrhythmia burden on left ventricular function. Kardiol Pol. 2017;75(7):698-704. doi: 10.5603/KP.a2017.0058.</citation>
    <PMID>28708198</PMID>
  </results_reference>
  <results_reference>
    <citation>Pedersen CT, Kay GN, Kalman J, Borggrefe M, Della-Bella P, Dickfeld T, Dorian P, Huikuri H, Kim YH, Knight B, Marchlinski F, Ross D, Sacher F, Sapp J, Shivkumar K, Soejima K, Tada H, Alexander ME, Triedman JK, Yamada T, Kirchhof P, Lip GY, Kuck KH, Mont L, Haines D, Indik J, Dimarco J, Exner D, Iesaka Y, Savelieva I; EP-Europace,UK. EHRA/HRS/APHRS expert consensus on ventricular arrhythmias. Heart Rhythm. 2014 Oct;11(10):e166-96. doi: 10.1016/j.hrthm.2014.07.024. Epub 2014 Aug 30. No abstract available.</citation>
    <PMID>25179489</PMID>
  </results_reference>
  <results_reference>
    <citation>Pytkowski M, Maciag A, Sterlinski M, Jankowska A, Kowalik I, Farkowski MM, Kuteszko R, Zajac D, Firek B, Chmielak Z, Szwed H. Novel algorithm for arrhythmogenic focus localization in patients with right ventricular outflow tract arrhythmias. Cardiol J. 2014;21(3):284-92. doi: 10.5603/CJ.a2013.0111. Epub 2013 Aug 30.</citation>
    <PMID>23990183</PMID>
  </results_reference>
  <results_reference>
    <citation>Timmermans C, Rodriguez LM, Crijns HJ, Moorman AF, Wellens HJ. Idiopathic left bundle-branch block-shaped ventricular tachycardia may originate above the pulmonary valve. Circulation. 2003 Oct 21;108(16):1960-7. doi: 10.1161/01.CIR.0000095026.19339.BB. Epub 2003 Oct 6.</citation>
    <PMID>14530199</PMID>
  </results_reference>
  <results_reference>
    <citation>Liao Z, Zhan X, Wu S, Xue Y, Fang X, Liao H, Deng H, Liang Y, Wei W, Liu Y, Ouyang F. Idiopathic Ventricular Arrhythmias Originating From the Pulmonary Sinus Cusp: Prevalence, Electrocardiographic/Electrophysiological Characteristics, and Catheter Ablation. J Am Coll Cardiol. 2015 Dec 15;66(23):2633-2644. doi: 10.1016/j.jacc.2015.09.094.</citation>
    <PMID>26670064</PMID>
  </results_reference>
  <results_reference>
    <citation>Kamioka M, Mathew S, Lin T, Metzner A, Rillig A, Deiss S, Rausch P, Lemes C, Makimoto H, Hu H, Liang D, Wissner E, Tilz RR, Kuck KH, Ouyang F. Electrophysiological and electrocardiographic predictors of ventricular arrhythmias originating from the left ventricular outflow tract within and below the coronary sinus cusps. Clin Res Cardiol. 2015 Jul;104(7):544-54. doi: 10.1007/s00392-015-0817-4. Epub 2015 Jan 30.</citation>
    <PMID>25633492</PMID>
  </results_reference>
  <results_reference>
    <citation>Yamada T, Litovsky SH, Kay GN. The left ventricular ostium: an anatomic concept relevant to idiopathic ventricular arrhythmias. Circ Arrhythm Electrophysiol. 2008 Dec;1(5):396-404. doi: 10.1161/CIRCEP.108.795948. No abstract available.</citation>
    <PMID>19808434</PMID>
  </results_reference>
  <results_reference>
    <citation>Ouyang F, Mathew S, Wu S, Kamioka M, Metzner A, Xue Y, Ju W, Yang B, Zhan X, Rillig A, Lin T, Rausch P, Deiss S, Lemes C, Tonnis T, Wissner E, Tilz RR, Kuck KH, Chen M. Ventricular arrhythmias arising from the left ventricular outflow tract below the aortic sinus cusps: mapping and catheter ablation via transseptal approach and electrocardiographic characteristics. Circ Arrhythm Electrophysiol. 2014 Jun;7(3):445-55. doi: 10.1161/CIRCEP.114.001690. Epub 2014 May 2. Erratum In: Circ Arrhythm Electrophysiol. 2014 Oct;7(5):996.</citation>
    <PMID>24795340</PMID>
  </results_reference>
  <results_reference>
    <citation>Ouyang F, Fotuhi P, Ho SY, Hebe J, Volkmer M, Goya M, Burns M, Antz M, Ernst S, Cappato R, Kuck KH. Repetitive monomorphic ventricular tachycardia originating from the aortic sinus cusp: electrocardiographic characterization for guiding catheter ablation. J Am Coll Cardiol. 2002 Feb 6;39(3):500-8. doi: 10.1016/s0735-1097(01)01767-3.</citation>
    <PMID>11823089</PMID>
  </results_reference>
  <results_reference>
    <citation>Yamada T, McElderry HT, Doppalapudi H, Okada T, Murakami Y, Yoshida Y, Yoshida N, Inden Y, Murohara T, Plumb VJ, Kay GN. Idiopathic ventricular arrhythmias originating from the left ventricular summit: anatomic concepts relevant to ablation. Circ Arrhythm Electrophysiol. 2010 Dec;3(6):616-23. doi: 10.1161/CIRCEP.110.939744. Epub 2010 Sep 20.</citation>
    <PMID>20855374</PMID>
  </results_reference>
  <results_reference>
    <citation>Ouyang F, Bansch D, Schaumann A, Ernst S, Linder C, Falk P, Hachiya H, Kuck KH, Antz M. Catheter ablation of subepicardial ventricular tachycardia using electroanatomic mapping. Herz. 2003 Nov;28(7):591-7. doi: 10.1007/s00059-003-2494-8.</citation>
    <PMID>14689119</PMID>
  </results_reference>
  <results_reference>
    <citation>Yokokawa M, Good E, Chugh A, Pelosi F Jr, Crawford T, Jongnarangsin K, Latchamsetty R, Oral H, Morady F, Bogun F. Intramural idiopathic ventricular arrhythmias originating in the intraventricular septum: mapping and ablation. Circ Arrhythm Electrophysiol. 2012 Apr;5(2):258-63. doi: 10.1161/CIRCEP.111.967257. Epub 2012 Mar 9.</citation>
    <PMID>22407415</PMID>
  </results_reference>
  <results_reference>
    <citation>Heeger CH, Hayashi K, Kuck KH, Ouyang F. Catheter Ablation of Idiopathic Ventricular Arrhythmias Arising From the Cardiac Outflow Tracts - Recent Insights and Techniques for the Successful Treatment of Common and Challenging Cases. Circ J. 2016 Apr 25;80(5):1073-86. doi: 10.1253/circj.CJ-16-0293. Epub 2016 Apr 13.</citation>
    <PMID>27074752</PMID>
  </results_reference>
  <verification_date>March 2020</verification_date>
  <study_first_submitted>August 20, 2017</study_first_submitted>
  <study_first_submitted_qc>August 20, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">August 23, 2017</study_first_posted>
  <last_update_submitted>March 10, 2020</last_update_submitted>
  <last_update_submitted_qc>March 10, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">March 12, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Assiut University</investigator_affiliation>
    <investigator_full_name>Mohamed Abo Elhassan Abdel_Rady</investigator_full_name>
    <investigator_title>M. abo Elhassan</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Arrhythmias, Cardiac</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03258112
org study id: electrophysiology
nct id: NCT03258112
lead sponsor: 
is fda regulated drug: No
is fda regulated device: No
Ventricular arrhythmias arising from cardiac outflow tract affect quality of life and can
      cause decrease in left ventricular ejection fraction.

      Drugs used for treating those arrhytmias may be ineffective or may have side effects.

      Radiofrequency catheter ablation can be used safely for treatment of outflow tract
      arrhythmias.

      There are different sites where those ventricular arrhythmias may originates, each site has
      different electrocardiographic characteristics, different procedural success rates and
      challenges in localization and ablation.
The right and left ventricular outflow tracts (RVOT/LVOT) are the most common sites of origin
      for idiopathic ventricular tachycardia (VT) and premature ventricular contractions (PVCs) in
      patients without structural heart disease.1

      Frequent PVCs was associated with PVC-induced cardiomyopathy, and radiofrequency (RF)
      catheter ablation of frequent PVCs was associated with improvement of left ventricular
      ejection fraction (LVEF).2

      The most common underlying pathophysiological mechanism was identified to be triggered
      activity and RF catheter ablation treatment is highly effective with low complication
      rates.1,3 Drug therapy has limited effectiveness (in case β-blockers and calcium-channel
      blockers) or drug-related side effects ( in case of flecainide, propafenone and amiodarone).4

      RF catheter ablation is recommended in cases of high PVC burden associated with decreased LV
      ejection fraction (LVEF) or in highly symptomatic patients despite optimal drug therapy.3

      Although the RVOT is the most common site (about 70-80% of cases) for idiopathic VAs1,5, only
      few studies have reported on the prevalence and RF catheter ablation of ventricular
      arrhythmias (VAs) arising from the pulmonary artery (21-46% among the RVOT VAs)6 and even
      less prevalence is reported in VAs arising from the pulmonary sinus cusps (11%).7

      Compared with VAs originating from the RVOT, ablation of LVOT-VAs is more complex and
      reported to be 12-45% of all idiopathic VAs.8-11 The success rate of ablation of LVOT-VA
      sites was previously reported to be lower (55-60%) without using antegrade/transseptal
      approaches.12,4 Rarely, it requires epicardial ablation via the GCV/AIV or subxiphoid
      puncture.13,14

      There are some cases in which RF catheter ablation cannot successfully be performed from
      either LVOT or RVOT. In such cases the VAs may originate from the LV-summit which is the most
      common site of idiopathic epicardial VAs from the LVOT region.13

      Although most idiopathic VAs originating from the cardiac OTs are suitable targets for
      endocardial RF catheter ablation, a small percentage of failures in these patients may be
      because of an inaccessible site of origin from epicardial or intramural septal
      locations.15The identification, mapping and RF catheter ablation of these idiopathic VAs may
      be challenging for the electrophysiologist and need special consideration.16
allocation: N/A
intervention model: Single Group Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: procedural success
time frame: 24 hours after the procedure
description: success of the procedure in ablation of ventricular arrhythmia with termination of ventricular arrhythmia, absence of induction of arrhythmia and 24 hours electrocardiographic monitoring after the procedure documenting absence of ventricular arrhythmia
measure: Recurrence of ventricular arrhythmia after three months
time frame: Three months
description: Appearance of symptoms of palpitation and documentation of recurrence of same type of arrhythmia with prolonged electrocardiographic monitoring in case of symptoms
arm group label: catheter ablation
arm group type: Other
description: all patients indicated for catheter ablation of RVOT or LVOT ventricular arrhythmia are included in one arm for electrophysiological diagnosis of the origin of arrhythmia then for radiofrequency catheter ablation
intervention type: Procedure
intervention name: Radiofrequency cardiac catheter ablation
description: procedure used for ablation of ventricular arrhythmia using catheters introduced to target sites percutaneously through venous or arterial systems using radiofrequency power
arm group label: catheter ablation
criteria: 
gender: All
minimum age: N/A
maximum age: N/A
healthy volunteers: No
last name: Mohamed Abo Elhassan Abdel-Rady
role: Principal Investigator
affiliation: Assiut University
citation: Latchamsetty R, Yokokawa M, Morady F, Kim HM, Mathew S, Tilz R, et al. Multicenter outcomes for catheter ablation of idiopathic premature ventricular complexes. J Am Coll Cardiol EP 2015; 1: 116 - 123
citation: Kumagai K. Idiopathic ventricular arrhythmias arising from the left ventricular outflow tract: Tips and tricks. J Arrythmia 2014; 30: 211 - 221
citation: Priori SG, Blomstrom-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekval TM, Spaulding C, Van Veldhuisen DJ; ESC Scientific Document Group. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J. 2015 Nov 1;36(41):2793-2867. doi: 10.1093/eurheartj/ehv316. Epub 2015 Aug 29. No abstract available.
PMID: 26320108
citation: Wojdyla-Hordynska A, Kowalski O, Hordynski GJ, Dinov B, Sommer P, Hindricks G, Feusette P, Arya A. The effect of radiofrequency catheter ablation of frequent premature ventricular complexes and arrhythmia burden on left ventricular function. Kardiol Pol. 2017;75(7):698-704. doi: 10.5603/KP.a2017.0058.
PMID: 28708198
citation: Pedersen CT, Kay GN, Kalman J, Borggrefe M, Della-Bella P, Dickfeld T, Dorian P, Huikuri H, Kim YH, Knight B, Marchlinski F, Ross D, Sacher F, Sapp J, Shivkumar K, Soejima K, Tada H, Alexander ME, Triedman JK, Yamada T, Kirchhof P, Lip GY, Kuck KH, Mont L, Haines D, Indik J, Dimarco J, Exner D, Iesaka Y, Savelieva I; EP-Europace,UK. EHRA/HRS/APHRS expert consensus on ventricular arrhythmias. Heart Rhythm. 2014 Oct;11(10):e166-96. doi: 10.1016/j.hrthm.2014.07.024. Epub 2014 Aug 30. No abstract available.
PMID: 25179489
citation: Pytkowski M, Maciag A, Sterlinski M, Jankowska A, Kowalik I, Farkowski MM, Kuteszko R, Zajac D, Firek B, Chmielak Z, Szwed H. Novel algorithm for arrhythmogenic focus localization in patients with right ventricular outflow tract arrhythmias. Cardiol J. 2014;21(3):284-92. doi: 10.5603/CJ.a2013.0111. Epub 2013 Aug 30.
PMID: 23990183
citation: Timmermans C, Rodriguez LM, Crijns HJ, Moorman AF, Wellens HJ. Idiopathic left bundle-branch block-shaped ventricular tachycardia may originate above the pulmonary valve. Circulation. 2003 Oct 21;108(16):1960-7. doi: 10.1161/01.CIR.0000095026.19339.BB. Epub 2003 Oct 6.
PMID: 14530199
citation: Liao Z, Zhan X, Wu S, Xue Y, Fang X, Liao H, Deng H, Liang Y, Wei W, Liu Y, Ouyang F. Idiopathic Ventricular Arrhythmias Originating From the Pulmonary Sinus Cusp: Prevalence, Electrocardiographic/Electrophysiological Characteristics, and Catheter Ablation. J Am Coll Cardiol. 2015 Dec 15;66(23):2633-2644. doi: 10.1016/j.jacc.2015.09.094.
PMID: 26670064
citation: Kamioka M, Mathew S, Lin T, Metzner A, Rillig A, Deiss S, Rausch P, Lemes C, Makimoto H, Hu H, Liang D, Wissner E, Tilz RR, Kuck KH, Ouyang F. Electrophysiological and electrocardiographic predictors of ventricular arrhythmias originating from the left ventricular outflow tract within and below the coronary sinus cusps. Clin Res Cardiol. 2015 Jul;104(7):544-54. doi: 10.1007/s00392-015-0817-4. Epub 2015 Jan 30.
PMID: 25633492
citation: Yamada T, Litovsky SH, Kay GN. The left ventricular ostium: an anatomic concept relevant to idiopathic ventricular arrhythmias. Circ Arrhythm Electrophysiol. 2008 Dec;1(5):396-404. doi: 10.1161/CIRCEP.108.795948. No abstract available.
PMID: 19808434
citation: Ouyang F, Mathew S, Wu S, Kamioka M, Metzner A, Xue Y, Ju W, Yang B, Zhan X, Rillig A, Lin T, Rausch P, Deiss S, Lemes C, Tonnis T, Wissner E, Tilz RR, Kuck KH, Chen M. Ventricular arrhythmias arising from the left ventricular outflow tract below the aortic sinus cusps: mapping and catheter ablation via transseptal approach and electrocardiographic characteristics. Circ Arrhythm Electrophysiol. 2014 Jun;7(3):445-55. doi: 10.1161/CIRCEP.114.001690. Epub 2014 May 2. Erratum In: Circ Arrhythm Electrophysiol. 2014 Oct;7(5):996.
PMID: 24795340
citation: Ouyang F, Fotuhi P, Ho SY, Hebe J, Volkmer M, Goya M, Burns M, Antz M, Ernst S, Cappato R, Kuck KH. Repetitive monomorphic ventricular tachycardia originating from the aortic sinus cusp: electrocardiographic characterization for guiding catheter ablation. J Am Coll Cardiol. 2002 Feb 6;39(3):500-8. doi: 10.1016/s0735-1097(01)01767-3.
PMID: 11823089
citation: Yamada T, McElderry HT, Doppalapudi H, Okada T, Murakami Y, Yoshida Y, Yoshida N, Inden Y, Murohara T, Plumb VJ, Kay GN. Idiopathic ventricular arrhythmias originating from the left ventricular summit: anatomic concepts relevant to ablation. Circ Arrhythm Electrophysiol. 2010 Dec;3(6):616-23. doi: 10.1161/CIRCEP.110.939744. Epub 2010 Sep 20.
PMID: 20855374
citation: Ouyang F, Bansch D, Schaumann A, Ernst S, Linder C, Falk P, Hachiya H, Kuck KH, Antz M. Catheter ablation of subepicardial ventricular tachycardia using electroanatomic mapping. Herz. 2003 Nov;28(7):591-7. doi: 10.1007/s00059-003-2494-8.
PMID: 14689119
citation: Yokokawa M, Good E, Chugh A, Pelosi F Jr, Crawford T, Jongnarangsin K, Latchamsetty R, Oral H, Morady F, Bogun F. Intramural idiopathic ventricular arrhythmias originating in the intraventricular septum: mapping and ablation. Circ Arrhythm Electrophysiol. 2012 Apr;5(2):258-63. doi: 10.1161/CIRCEP.111.967257. Epub 2012 Mar 9.
PMID: 22407415
citation: Heeger CH, Hayashi K, Kuck KH, Ouyang F. Catheter Ablation of Idiopathic Ventricular Arrhythmias Arising From the Cardiac Outflow Tracts - Recent Insights and Techniques for the Successful Treatment of Common and Challenging Cases. Circ J. 2016 Apr 25;80(5):1073-86. doi: 10.1253/circj.CJ-16-0293. Epub 2016 Apr 13.
PMID: 27074752
responsible party type: Principal Investigator
investigator affiliation: Assiut University
investigator full name: Mohamed Abo Elhassan Abdel_Rady
investigator title: M. abo Elhassan
mesh term: Arrhythmias, Cardiac