<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03242304</url>
  </required_header>
  <id_info>
    <org_study_id>act No. 393 of Nov 11, 2015</org_study_id>
    <nct_id>NCT03242304</nct_id>
  </id_info>
  <brief_title>Neuroactive Steroids in Acute Ischemic Stroke</brief_title>
  <acronym>Cortisol</acronym>
  <official_title>Changes in Plasma Cortisol, Brain-derived Neurotrophic Factor, and Nitrites in Patients With Acute Ischemic Stroke</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Hospital Militar Central, Argentina</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Hospital Militar Central, Argentina</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Acute ischemic stroke (AIS) represents an economical challenge for health systems all over&#xD;
      the globe. Despite increasing knowledge of the pathophysiology of AIS, there is no&#xD;
      satisfactory treatment to revert the resulting brain damage. Changes of neuroactive steroids&#xD;
      have been found in different neurological diseases. In this regard, the investigators have&#xD;
      previously demonstrated that old patients with AIS show changes of plasma cortisol and&#xD;
      estradiol concentrations, in that increased steroid levels are associated with a&#xD;
      deterioration of neurological status and a worse cognitive decline. The present study&#xD;
      assessed in patients with AIS if changes of behavior, brain-derived neurotrophic factor&#xD;
      (BDNF) and nitrites (NO-2) (nitric oxide soluble metabolite) bear a relationship with the&#xD;
      degree of hypercortisolism. To this purpose, the investigators recruited patients&#xD;
      hospitalized at the Central Military Hospital emergency room within the first 24 hours of&#xD;
      AIS. Subjects were divided into two groups, each one composed of 40 control subjects and 40&#xD;
      AIS patients, including men and women. The neurological condition was assessed using the&#xD;
      NIHSS and the cognitive status with the Montreal Cognitive Assessment (MoCA test). The&#xD;
      emotional status was evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS),&#xD;
      whereas the Modified Rankin Scale (MRS) was used to determine the functional condition. BDNF&#xD;
      and NO-2 plasma levels were measured by ELISA and the Griess reaction method, respectively.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Acute Ischemic Stroke (AIS) is one of the main causes of functional deterioration all over&#xD;
      the world. Thus, 26% of patients older than 65 years still show limitations of daily&#xD;
      activities 6 months after AIS, and 46% of these patients present cognitive deficiency of&#xD;
      variable severity. AIS impose a burden on the way of living of patients and their families'&#xD;
      in which depression emerges as a frequent neuropsychiatric disorder after the ischemic event.&#xD;
      However, the occurrence of depression and other functional abnormalities on the first day&#xD;
      following AIS is largely unknown. Neuroactive steroids have the capability to modulate in a&#xD;
      positive or negative way the function of the nervous system. Changes in neuroactive steroid&#xD;
      concentrations in plasma and nervous system have been described in degenerative diseases&#xD;
      (Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral&#xD;
      sclerosis), autoimmune diseases (multiple sclerosis), epilepsy, and psychiatric disorders&#xD;
      (depression and schizophrenia). In vulnerable regions such as the hippocampus and prefrontal&#xD;
      cortex, high cortisol exposure damages the pyramidal neurons, decreases neurogenesis and&#xD;
      impairs memory and learning. In a previous report, the investigators have demonstrated that&#xD;
      old patients with AIS show changes in the plasma levels of cortisol and estradiol, which&#xD;
      associate with low cognition, worse neurological status, and poor functional performance. The&#xD;
      present report investigated changes of cortisol, brain-derived neurotrophic factor (BDNF) and&#xD;
      nitrites (NO-2, nitric oxide soluble metabolites) after AIS. BDNF is a neurotrophin&#xD;
      classically associated with learning and memory and negatively modulated by glucocorticoids,&#xD;
      old age, and neurodegenerative diseases. In plasma, platelets are the major source of&#xD;
      peripheral BDNF and levels of this neurotrophin are decreased in Alzheimer´s disease and&#xD;
      depression. These disorders also show hypercortisolism and changes of cortisol dynamics&#xD;
      suggesting that steroids, neurotrophins, and behavioral deficits may be functionally related.&#xD;
      Regarding nitrites, cortisol treatment of human subjects significantly reduced plasma&#xD;
      nitrate/nitrite concentrations. Therefore, considering that opposite changes occur in&#xD;
      cortisol vs. BDNF and nitrites, the investigators aimed to determine in acute AIS patients&#xD;
      (a) changes in plasma cortisol; (b) development of clinical, behavioral and functional&#xD;
      deficits; (c) changes in plasma BDNF and nitrites, which may predict a neurotoxic effect of&#xD;
      the excess cortisol in the ischemic nervous system.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">April 1, 2016</start_date>
  <completion_date type="Actual">December 1, 2016</completion_date>
  <primary_completion_date type="Actual">December 1, 2016</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Control</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Neurological déficit</measure>
    <time_frame>Into 24 hours of Acute Ischemic Stroke</time_frame>
    <description>The neurological state during AIS was quantified by the National Institute of Health stroke scale at the time of hospitalization (NIHSS,available at http://www.ninds.nih.gov/doctors/NIH_Stroke_Scale.pdf</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Cognition</measure>
    <time_frame>Into 24 hours of Acute Ischemic Stroke</time_frame>
    <description>The cognitive test used was the Montreal Cognitive Assessment (MoCA test).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Emotional state</measure>
    <time_frame>Into 24 hours of Acute Ischemic Stroke</time_frame>
    <description>Patients with AIS were evaluated on the Montgomery-Asberg depression scale (MADRS)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Functional dependency of daily life activities</measure>
    <time_frame>Into 24 hours of Acute Ischemic Stroke</time_frame>
    <description>The functional state of the AIS patients was assessed by the modified Rankin scale at the time of entering the admission floor.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cortisol</measure>
    <time_frame>Into 24 hours of Acute Ischemic Stroke</time_frame>
    <description>Plasma cortisol concentration was determined by chemiluminescent microparticle immunoassay (CMIA), using Team Architect i1000, Abbott Laboratories, Middletown, USA.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Quantification of nitrites concentration (NO-2)</measure>
    <time_frame>Into 24 hours of Acute Ischemic Stroke</time_frame>
    <description>Levels of NO-2, nitric oxide soluble metabolite (ON.) in water, were measured spectrophotometrically at 543 nm absorbance by the Griess reactio</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>BDNF quantification in plasma</measure>
    <time_frame>Into 24 hours of Acute Ischemic Stroke</time_frame>
    <description>Plasma BDNF concentration was measured by enzyme-linked immunosorbent assay (ELISA)</description>
  </secondary_outcome>
  <number_of_groups>2</number_of_groups>
  <enrollment type="Actual">40</enrollment>
  <condition>Ischemic Stroke</condition>
  <condition>Cortisol; Hypersecretion</condition>
  <arm_group>
    <arm_group_label>Control group</arm_group_label>
    <description>A control group composed of subjects without physical or psychiatric disease.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Acute Ischemic Stroke group</arm_group_label>
    <description>An AIS group composed of subjects within the first 24 hours of the neurovascular event.</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Behavioral tests</intervention_name>
    <description>We observed relationship between plasma levels of cortisol and neurological, cognitive, functional and emotional outcomes in patients with acute ischemic stroke.</description>
    <arm_group_label>Acute Ischemic Stroke group</arm_group_label>
    <arm_group_label>Control group</arm_group_label>
    <other_name>Plasma cortisol levels quantification</other_name>
    <other_name>Plasma nitrites levels quantification</other_name>
    <other_name>Plasma Brain Derived Neurotrophic Factor quantification</other_name>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        The subjects were between 60 and 90 years old, and were recruited randomly and distributed&#xD;
        in two experimental groups: 1) a control group composed of subjects without physical or&#xD;
        psychiatric disease, 2) an AIS group composed of subjects within the first 24 hours of the&#xD;
        neurovascular event. The individuals were distributed in such a way that each experimental&#xD;
        group contained 10 men and 10 women. Table 1 show the inclusion and exclusion criteria used&#xD;
        for the AIS group.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Age between 60 and 90 years.&#xD;
&#xD;
          -  Agreeing to participate in the study.&#xD;
&#xD;
          -  Acute Ischemic Stroke of anterior vascular territory and/or posterior vascular&#xD;
             territory whithin 24 hours of onset.&#xD;
&#xD;
          -  Nine or more points in the Glasgow Coma Scale.&#xD;
&#xD;
          -  Female patients in menopause.&#xD;
&#xD;
          -  Patients without cognitive impairment before AIS according to family reference.&#xD;
&#xD;
          -  Acceptance of the next of kin proxy in case the participant has sensory impairment.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Age &lt;60 or &gt; 90 years.&#xD;
&#xD;
          -  Hemorrhagic Stroke.&#xD;
&#xD;
          -  Transient ischemic attack (TIA).&#xD;
&#xD;
          -  Acute Ischemic Stroke after 24 hours of onset.&#xD;
&#xD;
          -  Hormonal replacement therapy.&#xD;
&#xD;
          -  Immunosuppressive therapy in the last month before AIS (example corticosteroids).&#xD;
&#xD;
          -  Acute infection (Example, pneumonia, urinary tract infection).&#xD;
&#xD;
          -  Diagnosis of oncologic disease in the last month before AIS.&#xD;
&#xD;
          -  Diagnosis of endocrinologic disease in the last month before AIS.&#xD;
&#xD;
          -  Acute or long-term psychiatric illness.&#xD;
&#xD;
          -  No agreement to participate in the study.&#xD;
&#xD;
          -  Eight or less points in the Glasgow Coma Scale.&#xD;
&#xD;
          -  Female patients with menstrual cycle or in the perimenopause.&#xD;
&#xD;
          -  Patients with kidney or hepatic illness.&#xD;
&#xD;
          -  Patients with cognitive impairment before AIS.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>60 Years</minimum_age>
    <maximum_age>90 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Sebastian M Casas, Ph.D., MD.</last_name>
    <role>Principal Investigator</role>
    <affiliation>Hospital Militar Central Cir My ¨Dr. Cosme Argerich¨</affiliation>
  </overall_official>
  <results_reference>
    <citation>Casas S, Gonzalez Deniselle MC, Gargiulo-Monachelli GM, Perez AF, Tourreilles M, Mattiazzi M, Ojeda C, Lotero Polesel D, De Nicola AF. Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes. Horm Metab Res. 2017 Jan;49(1):16-22. doi: 10.1055/s-0042-119201. Epub 2016 Nov 3.</citation>
    <PMID>27813048</PMID>
  </results_reference>
  <results_reference>
    <citation>Yunes R, Casas S, Gaglio E, Cabrera R. Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3 alpha -Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of GABAA Receptors Involvement. Parkinsons Dis. 2015;2015:431690. doi: 10.1155/2015/431690. Epub 2015 Mar 31.</citation>
    <PMID>25918669</PMID>
  </results_reference>
  <results_reference>
    <citation>Casas S, Giuliani F, Cremaschi F, Yunes R, Cabrera R. Neuromodulatory effect of progesterone on the dopaminergic, glutamatergic, and GABAergic activities in a male rat model of Parkinson's disease. Neurol Res. 2013 Sep;35(7):719-25. doi: 10.1179/1743132812Y.0000000142. Epub 2013 Mar 5.</citation>
    <PMID>23561326</PMID>
  </results_reference>
  <results_reference>
    <citation>Escudero C, Casas S, Giuliani F, Bazzocchini V, Garcia S, Yunes R, Cabrera R. Allopregnanolone prevents memory impairment: effect on mRNA expression and enzymatic activity of hippocampal 3-alpha hydroxysteroid oxide-reductase. Brain Res Bull. 2012 Feb 10;87(2-3):280-5. doi: 10.1016/j.brainresbull.2011.11.019. Epub 2011 Dec 6. Erratum In: Brain Res Bull. 2012 Nov 1;89(3-4):150.</citation>
    <PMID>22155686</PMID>
  </results_reference>
  <results_reference>
    <citation>Ghersi MS, Casas SM, Escudero C, Carlini VP, Buteler F, Cabrera RJ, Schioth HB, de Barioglio SR. Ghrelin inhibited serotonin release from hippocampal slices. Peptides. 2011 Nov;32(11):2367-71. doi: 10.1016/j.peptides.2011.07.015. Epub 2011 Jul 27.</citation>
    <PMID>21820473</PMID>
  </results_reference>
  <results_reference>
    <citation>Casas S, Garcia S, Cabrera R, Nanfaro F, Escudero C, Yunes R. Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats. Pharmacol Biochem Behav. 2011 Oct;99(4):614-8. doi: 10.1016/j.pbb.2011.06.012. Epub 2011 Jun 15.</citation>
    <PMID>21689676</PMID>
  </results_reference>
  <verification_date>August 2017</verification_date>
  <study_first_submitted>August 2, 2017</study_first_submitted>
  <study_first_submitted_qc>August 7, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">August 8, 2017</study_first_posted>
  <last_update_submitted>August 7, 2017</last_update_submitted>
  <last_update_submitted_qc>August 7, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">August 8, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Hospital Militar Central, Argentina</investigator_affiliation>
    <investigator_full_name>Sebastian Casas</investigator_full_name>
    <investigator_title>Ph.D, M.D.</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Stroke</mesh_term>
    <mesh_term>Ischemic Stroke</mesh_term>
    <mesh_term>Cerebral Infarction</mesh_term>
    <mesh_term>Ischemia</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Hydrocortisone</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03242304
org study id: act No. 393 of Nov 11, 2015
nct id: NCT03242304
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
Acute ischemic stroke (AIS) represents an economical challenge for health systems all over
      the globe. Despite increasing knowledge of the pathophysiology of AIS, there is no
      satisfactory treatment to revert the resulting brain damage. Changes of neuroactive steroids
      have been found in different neurological diseases. In this regard, the investigators have
      previously demonstrated that old patients with AIS show changes of plasma cortisol and
      estradiol concentrations, in that increased steroid levels are associated with a
      deterioration of neurological status and a worse cognitive decline. The present study
      assessed in patients with AIS if changes of behavior, brain-derived neurotrophic factor
      (BDNF) and nitrites (NO-2) (nitric oxide soluble metabolite) bear a relationship with the
      degree of hypercortisolism. To this purpose, the investigators recruited patients
      hospitalized at the Central Military Hospital emergency room within the first 24 hours of
      AIS. Subjects were divided into two groups, each one composed of 40 control subjects and 40
      AIS patients, including men and women. The neurological condition was assessed using the
      NIHSS and the cognitive status with the Montreal Cognitive Assessment (MoCA test). The
      emotional status was evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS),
      whereas the Modified Rankin Scale (MRS) was used to determine the functional condition. BDNF
      and NO-2 plasma levels were measured by ELISA and the Griess reaction method, respectively.
Acute Ischemic Stroke (AIS) is one of the main causes of functional deterioration all over
      the world. Thus, 26% of patients older than 65 years still show limitations of daily
      activities 6 months after AIS, and 46% of these patients present cognitive deficiency of
      variable severity. AIS impose a burden on the way of living of patients and their families'
      in which depression emerges as a frequent neuropsychiatric disorder after the ischemic event.
      However, the occurrence of depression and other functional abnormalities on the first day
      following AIS is largely unknown. Neuroactive steroids have the capability to modulate in a
      positive or negative way the function of the nervous system. Changes in neuroactive steroid
      concentrations in plasma and nervous system have been described in degenerative diseases
      (Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral
      sclerosis), autoimmune diseases (multiple sclerosis), epilepsy, and psychiatric disorders
      (depression and schizophrenia). In vulnerable regions such as the hippocampus and prefrontal
      cortex, high cortisol exposure damages the pyramidal neurons, decreases neurogenesis and
      impairs memory and learning. In a previous report, the investigators have demonstrated that
      old patients with AIS show changes in the plasma levels of cortisol and estradiol, which
      associate with low cognition, worse neurological status, and poor functional performance. The
      present report investigated changes of cortisol, brain-derived neurotrophic factor (BDNF) and
      nitrites (NO-2, nitric oxide soluble metabolites) after AIS. BDNF is a neurotrophin
      classically associated with learning and memory and negatively modulated by glucocorticoids,
      old age, and neurodegenerative diseases. In plasma, platelets are the major source of
      peripheral BDNF and levels of this neurotrophin are decreased in Alzheimer´s disease and
      depression. These disorders also show hypercortisolism and changes of cortisol dynamics
      suggesting that steroids, neurotrophins, and behavioral deficits may be functionally related.
      Regarding nitrites, cortisol treatment of human subjects significantly reduced plasma
      nitrate/nitrite concentrations. Therefore, considering that opposite changes occur in
      cortisol vs. BDNF and nitrites, the investigators aimed to determine in acute AIS patients
      (a) changes in plasma cortisol; (b) development of clinical, behavioral and functional
      deficits; (c) changes in plasma BDNF and nitrites, which may predict a neurotoxic effect of
      the excess cortisol in the ischemic nervous system.
observational model: Case-Control
time perspective: Prospective
measure: Neurological déficit
time frame: Into 24 hours of Acute Ischemic Stroke
description: The neurological state during AIS was quantified by the National Institute of Health stroke scale at the time of hospitalization (NIHSS,available at http://www.ninds.nih.gov/doctors/NIH_Stroke_Scale.pdf
measure: Cognition
time frame: Into 24 hours of Acute Ischemic Stroke
description: The cognitive test used was the Montreal Cognitive Assessment (MoCA test).
measure: Emotional state
time frame: Into 24 hours of Acute Ischemic Stroke
description: Patients with AIS were evaluated on the Montgomery-Asberg depression scale (MADRS)
measure: Functional dependency of daily life activities
time frame: Into 24 hours of Acute Ischemic Stroke
description: The functional state of the AIS patients was assessed by the modified Rankin scale at the time of entering the admission floor.
measure: Cortisol
time frame: Into 24 hours of Acute Ischemic Stroke
description: Plasma cortisol concentration was determined by chemiluminescent microparticle immunoassay (CMIA), using Team Architect i1000, Abbott Laboratories, Middletown, USA.
measure: Quantification of nitrites concentration (NO-2)
time frame: Into 24 hours of Acute Ischemic Stroke
description: Levels of NO-2, nitric oxide soluble metabolite (ON.) in water, were measured spectrophotometrically at 543 nm absorbance by the Griess reactio
measure: BDNF quantification in plasma
time frame: Into 24 hours of Acute Ischemic Stroke
description: Plasma BDNF concentration was measured by enzyme-linked immunosorbent assay (ELISA)
arm group label: Control group
description: A control group composed of subjects without physical or psychiatric disease.
arm group label: Acute Ischemic Stroke group
description: An AIS group composed of subjects within the first 24 hours of the neurovascular event.
intervention type: Other
intervention name: Behavioral tests
description: We observed relationship between plasma levels of cortisol and neurological, cognitive, functional and emotional outcomes in patients with acute ischemic stroke.
arm group label: Acute Ischemic Stroke group
arm group label: Control group
other name: Plasma cortisol levels quantification
other name: Plasma nitrites levels quantification
other name: Plasma Brain Derived Neurotrophic Factor quantification
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 60 Years
maximum age: 90 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Sebastian M Casas, Ph.D., MD.
role: Principal Investigator
affiliation: Hospital Militar Central Cir My ¨Dr. Cosme Argerich¨
citation: Casas S, Gonzalez Deniselle MC, Gargiulo-Monachelli GM, Perez AF, Tourreilles M, Mattiazzi M, Ojeda C, Lotero Polesel D, De Nicola AF. Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes. Horm Metab Res. 2017 Jan;49(1):16-22. doi: 10.1055/s-0042-119201. Epub 2016 Nov 3.
PMID: 27813048
citation: Yunes R, Casas S, Gaglio E, Cabrera R. Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3 alpha -Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of GABAA Receptors Involvement. Parkinsons Dis. 2015;2015:431690. doi: 10.1155/2015/431690. Epub 2015 Mar 31.
PMID: 25918669
citation: Casas S, Giuliani F, Cremaschi F, Yunes R, Cabrera R. Neuromodulatory effect of progesterone on the dopaminergic, glutamatergic, and GABAergic activities in a male rat model of Parkinson's disease. Neurol Res. 2013 Sep;35(7):719-25. doi: 10.1179/1743132812Y.0000000142. Epub 2013 Mar 5.
PMID: 23561326
citation: Escudero C, Casas S, Giuliani F, Bazzocchini V, Garcia S, Yunes R, Cabrera R. Allopregnanolone prevents memory impairment: effect on mRNA expression and enzymatic activity of hippocampal 3-alpha hydroxysteroid oxide-reductase. Brain Res Bull. 2012 Feb 10;87(2-3):280-5. doi: 10.1016/j.brainresbull.2011.11.019. Epub 2011 Dec 6. Erratum In: Brain Res Bull. 2012 Nov 1;89(3-4):150.
PMID: 22155686
citation: Ghersi MS, Casas SM, Escudero C, Carlini VP, Buteler F, Cabrera RJ, Schioth HB, de Barioglio SR. Ghrelin inhibited serotonin release from hippocampal slices. Peptides. 2011 Nov;32(11):2367-71. doi: 10.1016/j.peptides.2011.07.015. Epub 2011 Jul 27.
PMID: 21820473
citation: Casas S, Garcia S, Cabrera R, Nanfaro F, Escudero C, Yunes R. Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats. Pharmacol Biochem Behav. 2011 Oct;99(4):614-8. doi: 10.1016/j.pbb.2011.06.012. Epub 2011 Jun 15.
PMID: 21689676
responsible party type: Principal Investigator
investigator affiliation: Hospital Militar Central, Argentina
investigator full name: Sebastian Casas
investigator title: Ph.D, M.D.
mesh term: Stroke
mesh term: Ischemic Stroke
mesh term: Cerebral Infarction
mesh term: Ischemia
mesh term: Hydrocortisone
sharing ipd: No