<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03293199</url>
  </required_header>
  <id_info>
    <org_study_id>IR.AJAUMS.REC.1396.24</org_study_id>
    <nct_id>NCT03293199</nct_id>
  </id_info>
  <brief_title>Comparing Efficacy of Chest Tube Drainage and Needle Aspiration in Pneumothorax Treatment</brief_title>
  <official_title>Randomized Controlled Trial on Comparison of Chest Tube Drainage and Needle Aspiration in Treatment of Spontaneous Pneumothorax</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Tabriz University of Medical Sciences</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>AJA University of Medical Sciences</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Tabriz University of Medical Sciences</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
    <is_us_export>No</is_us_export>
  </oversight_info>
  <brief_summary>
    <textblock>
      Spontaneous pneumothorax is a common condition which is defined as air presence inside of&#xD;
      pleural space. Despite, several studies that have been carried on management patients&#xD;
      suffering spontaneous pneumothorax, the first step approach on patients is still the topic of&#xD;
      debate. Since chest tube drainage and needle aspiration are widely used first step techniques&#xD;
      in spontaneous pneumothorax, current study compares the efficacy of abovementioned&#xD;
      techniques, as well as long-term outcomes. In current multi-center single-blinded RCT, all&#xD;
      patients admitted with spontaneous pneumothorax will be enrolled study and written consent&#xD;
      form provided by patients, simultaneously. Patients randomly assigned to study groups&#xD;
      including (A) chest tube drainage and (B) needle aspiration. Subsequently, all patients will&#xD;
      undergo one-year follow-up and will be evaluated in terms of treatment success rate and&#xD;
      pneumothorax recurrence. Hypothesis of present trial are as follows: a) repetitive needle&#xD;
      aspiration may lead to higher treatment success rate in patients with primary spontaneous&#xD;
      pneumothorax, in comparison to chest tube drainage, b) needle aspiration may result in&#xD;
      reduction of hospital admission duration in patients with primary spontaneous pneumothorax&#xD;
      compared to chest tube drainage, c) the rate of spontaneous pneumothorax recurrence during&#xD;
      one-year follow up might be lower in patients who undergo needle aspiration instead of chest&#xD;
      tube drainage.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The chest tube drainage and needle aspiration are widely used first step techniques in&#xD;
      spontaneous pneumothorax, thus present randomized controlled trial (RCT) aims to compare the&#xD;
      efficacy of abovementioned techniques, as well as long-term outcomes. The study protocol has&#xD;
      been confirmed by the ethics committee of AJA University. In current multi-center&#xD;
      single-blinded RCT, all patients admitted with primary spontaneous pneumothorax will be&#xD;
      enrolled study and written consent form provided by patients, simultaneously. With due&#xD;
      attention to the success rate of 18% provided in a previous study comparing primary&#xD;
      spontaneous pneumothorax treatment procedures and the study power of 80% and the confidence&#xD;
      coefficient of 0.05, study population calculated to include 64 patient, which increased to 70&#xD;
      patients with taking 10% of falling risk into consideration. Using Randlist software,&#xD;
      patients will be randomly assigned to study groups including (A) chest tube drainage and (B)&#xD;
      needle aspiration. Subsequently, all patients will undergo one-year follow-up and will be&#xD;
      evaluated in terms of treatment success rate and pneumothorax recurrence.&#xD;
&#xD;
      In chest tube drainage group, while the patient is positioned in the supine position and&#xD;
      subsequent to local anesthesia administration via lidocaine 2%, F16 or F20 (based on patients&#xD;
      physical status) sterile plastic tube will be implemented at the level 4th or 5th intercostal&#xD;
      space through the midaxillary line. However, in needle aspiration group, patients will be&#xD;
      positioned semi-supine. Subsequently, G16 intravenous angiocath will be inserted through the&#xD;
      midclavicular line at the level 2nd or 3rd intercostal space. The catheter needle will be&#xD;
      removed and catheter will be fixed using sterile sticks. A three-way valve will be connected&#xD;
      to the external end of the catheter and a 50 ml syringe will be connected to the valve. The&#xD;
      air suction will be performed using 50 ml syringe till end of the air suction or up to 3.5&#xD;
      liters of air suctioning.&#xD;
&#xD;
      Hypothesis of present trial are as follows: a) repetitive needle aspiration may lead to&#xD;
      higher treatment success rate in patients with primary spontaneous pneumothorax, in&#xD;
      comparison to chest tube drainage, b) needle aspiration may result in reduction of hospital&#xD;
      admission duration in patients with primary spontaneous pneumothorax compared to chest tube&#xD;
      drainage, c) the rate of spontaneous pneumothorax recurrence during one-year follow-up might&#xD;
      be lower in patients who undergo needle aspiration instead of chest tube drainage.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">August 12, 2017</start_date>
  <completion_date type="Anticipated">October 12, 2018</completion_date>
  <primary_completion_date type="Anticipated">July 12, 2018</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>Patients will be randomly and equally assigned to study groups, as follows: group (a) will undergo chest tube drainage implementation and group (b) will undergo repetitive needle aspiration till pnuemothorax resolution.</intervention_model_description>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Investigator, Outcomes Assessor)</masking>
    <masking_description>Since patients are alert and conscious, therefore we are unable to blind the participants. However, care provider will not take part in the data acquisition and outcome analysis. The investigator and outcome assessor will be blinded to patients allocated group and treatment type provided in each patients.</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Pneumothorax recurrence during one-year</measure>
    <time_frame>One year postoperative</time_frame>
    <description>Will be defined as the rate of pneumothorax recurrence until postoperative one-year.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Successful treatment rate</measure>
    <time_frame>Postoperative day 1 and postoperative day 7</time_frame>
    <description>Is defined as completely resolved pneumothorax during admission.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Length of hospital admission</measure>
    <time_frame>Through hospital admission, an average of 10 days</time_frame>
    <description>will be calculated from the time of the operation to time of discharge.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Operation time</measure>
    <time_frame>During procedure</time_frame>
    <description>Will be calculated from the time of skin incision to completing the procedure including complete chest tube insertion in chest tube group or complete air suction or up to 3.5 liters of air suction in needle aspiration group.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Procedure induced complications</measure>
    <time_frame>Postoperative day 1, Postoperative day 3, Postoperative day 7, Postoperative month 1,</time_frame>
    <description>Includes all complications occurred during or after procedure during hospital stay.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pneumothorax size</measure>
    <time_frame>Before procedure, 1 hour after procedure, 48 hours after procedure, one-week after procedure</time_frame>
    <description>Will be calculated by Light's formula using chest radiography</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">70</enrollment>
  <condition>Pneumothorax Spontaneous Primary</condition>
  <condition>Pneumothorax, Recurrent</condition>
  <condition>Pneumothorax Spontaneous Tension</condition>
  <condition>Pneumothorax, Spontaneous</condition>
  <arm_group>
    <arm_group_label>Chest tube drainage</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>This group will undergo chest tube drainage as an intervention for spontaneous pneumothorax treatment.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Needle aspiration</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>This group will undergo repetitive needle aspiration as an intervention for spontaneous pneumothorax treatment.</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Chest tube drainage</intervention_name>
    <description>In this group, in the supine position and subsequent to prepping and draping and local anesthesia administration via lidocaine 2%, F16 or F20 (based on patients physical status) sterile plastic tube will be implemented at the level 4th or 5th intercostal space through the midaxillary line. Subsequently, the external end of the tube will be connected to water sealing bottle and water bubbles coming out will be considered as proper chest tube insertion.</description>
    <arm_group_label>Chest tube drainage</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Repetitive needle aspiration</intervention_name>
    <description>In this group, prior to needle aspiration, patients will take the semi-supine position. Subsequent to local anesthesia via lidocaine 2%, as well as prepping and draping, G16 intravenous angiocath will be inserted through midclavicular line at the level 2nd or 3rd intercostal space. Air bubble inside the lidocaine syringe will be considered as needled entrance to pleural cavity, thus 5-10 cm of the angiocath will be import to inside of the cavity. The catheter needle will be removed and catheter will be fixed using sterile sticks. A three-way valve will be connected to external end of the catheter and a 50 ml syringe will be connected to the valve. The air suction will be performed using 50 ml syringe till end of the air suction or up to 3.5 liters of air suctioning.</description>
    <arm_group_label>Needle aspiration</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Aged more than 18 years old&#xD;
&#xD;
          -  Symptomatic primary spontaneous pneumothorax or intervention-needed spontaneous&#xD;
             pneumothorax (pneumothorax more than 20% in volume due to Light criteria)&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Tension pneumothorax&#xD;
&#xD;
          -  bilateral severe respiratory failure&#xD;
&#xD;
          -  demand for mechanical ventilation&#xD;
&#xD;
          -  bilateral pneumothorax&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_contact>
    <last_name>Ali Ramouz</last_name>
    <phone>+989399418336</phone>
    <email>ramouza@tbzmed.ac.ir</email>
  </overall_contact>
  <location>
    <facility>
      <name>Imam Reza hospital</name>
      <address>
        <city>Tabriz</city>
        <state>East Azerbaijan</state>
        <country>Iran, Islamic Republic of</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Seyed Ziaeddin Rasihashemi, Professor</last_name>
      <phone>+989144126652</phone>
      <email>zia.hashemi@yahoo.com</email>
    </contact>
    <investigator>
      <last_name>Ali Ramouz</last_name>
      <role>Principal Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>Iran, Islamic Republic of</country>
  </location_countries>
  <reference>
    <citation>Tschopp JM, Marquette CH. Spontaneous pneumothorax: stop chest tube as first-line therapy. Eur Respir J. 2017 Apr 12;49(4):1700306. doi: 10.1183/13993003.00306-2017. Print 2017 Apr. No abstract available.</citation>
    <PMID>28404655</PMID>
  </reference>
  <reference>
    <citation>Hu X, Cowl CT, Baqir M, Ryu JH. Air travel and pneumothorax. Chest. 2014 Apr;145(4):688-694. doi: 10.1378/chest.13-2363.</citation>
    <PMID>24687705</PMID>
  </reference>
  <reference>
    <citation>Cran IR, Rumball CA. Survey of spontaneous pneumothoraces in the Royal Air Force. Thorax. 1967 Sep;22(5):462-5. doi: 10.1136/thx.22.5.462.</citation>
    <PMID>6050294</PMID>
  </reference>
  <reference>
    <citation>Harvey J, Prescott RJ. Simple aspiration versus intercostal tube drainage for spontaneous pneumothorax in patients with normal lungs. British Thoracic Society Research Committee. BMJ. 1994 Nov 19;309(6965):1338-9. doi: 10.1136/bmj.309.6965.1338. No abstract available.</citation>
    <PMID>7755720</PMID>
  </reference>
  <reference>
    <citation>Dzeljilji A, Rokicki W, Rokicki M, Karus K. New aspects in the diagnosis and treatment of primary spontaneous pneumothorax. Kardiochir Torakochirurgia Pol. 2017 Mar;14(1):27-31. doi: 10.5114/kitp.2017.66926. Epub 2017 Mar 31.</citation>
    <PMID>28515745</PMID>
  </reference>
  <reference>
    <citation>MacDuff A, Arnold A, Harvey J; BTS Pleural Disease Guideline Group. Management of spontaneous pneumothorax: British Thoracic Society Pleural Disease Guideline 2010. Thorax. 2010 Aug;65 Suppl 2:ii18-31. doi: 10.1136/thx.2010.136986. No abstract available.</citation>
    <PMID>20696690</PMID>
  </reference>
  <reference>
    <citation>Thelle A, Gjerdevik M, SueChu M, Hagen OM, Bakke P. Randomised comparison of needle aspiration and chest tube drainage in spontaneous pneumothorax. Eur Respir J. 2017 Apr 12;49(4):1601296. doi: 10.1183/13993003.01296-2016. Print 2017 Apr.</citation>
    <PMID>28404647</PMID>
  </reference>
  <reference>
    <citation>Tschopp JM, Bintcliffe O, Astoul P, Canalis E, Driesen P, Janssen J, Krasnik M, Maskell N, Van Schil P, Tonia T, Waller DA, Marquette CH, Cardillo G. ERS task force statement: diagnosis and treatment of primary spontaneous pneumothorax. Eur Respir J. 2015 Aug;46(2):321-35. doi: 10.1183/09031936.00219214. Epub 2015 Jun 25.</citation>
    <PMID>26113675</PMID>
  </reference>
  <reference>
    <citation>Wakai A, O'Sullivan RG, McCabe G. Simple aspiration versus intercostal tube drainage for primary spontaneous pneumothorax in adults. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD004479. doi: 10.1002/14651858.CD004479.pub2.</citation>
    <PMID>17253510</PMID>
  </reference>
  <verification_date>September 2017</verification_date>
  <study_first_submitted>September 18, 2017</study_first_submitted>
  <study_first_submitted_qc>September 21, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">September 26, 2017</study_first_posted>
  <last_update_submitted>September 21, 2017</last_update_submitted>
  <last_update_submitted_qc>September 21, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">September 26, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Tabriz University of Medical Sciences</investigator_affiliation>
    <investigator_full_name>Ali Ramouz</investigator_full_name>
    <investigator_title>Doctor</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Pneumothorax</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03293199
org study id: IR.AJAUMS.REC.1396.24
nct id: NCT03293199
lead sponsor: 
collaborator: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
is us export: No
Spontaneous pneumothorax is a common condition which is defined as air presence inside of
      pleural space. Despite, several studies that have been carried on management patients
      suffering spontaneous pneumothorax, the first step approach on patients is still the topic of
      debate. Since chest tube drainage and needle aspiration are widely used first step techniques
      in spontaneous pneumothorax, current study compares the efficacy of abovementioned
      techniques, as well as long-term outcomes. In current multi-center single-blinded RCT, all
      patients admitted with spontaneous pneumothorax will be enrolled study and written consent
      form provided by patients, simultaneously. Patients randomly assigned to study groups
      including (A) chest tube drainage and (B) needle aspiration. Subsequently, all patients will
      undergo one-year follow-up and will be evaluated in terms of treatment success rate and
      pneumothorax recurrence. Hypothesis of present trial are as follows: a) repetitive needle
      aspiration may lead to higher treatment success rate in patients with primary spontaneous
      pneumothorax, in comparison to chest tube drainage, b) needle aspiration may result in
      reduction of hospital admission duration in patients with primary spontaneous pneumothorax
      compared to chest tube drainage, c) the rate of spontaneous pneumothorax recurrence during
      one-year follow up might be lower in patients who undergo needle aspiration instead of chest
      tube drainage.
The chest tube drainage and needle aspiration are widely used first step techniques in
      spontaneous pneumothorax, thus present randomized controlled trial (RCT) aims to compare the
      efficacy of abovementioned techniques, as well as long-term outcomes. The study protocol has
      been confirmed by the ethics committee of AJA University. In current multi-center
      single-blinded RCT, all patients admitted with primary spontaneous pneumothorax will be
      enrolled study and written consent form provided by patients, simultaneously. With due
      attention to the success rate of 18% provided in a previous study comparing primary
      spontaneous pneumothorax treatment procedures and the study power of 80% and the confidence
      coefficient of 0.05, study population calculated to include 64 patient, which increased to 70
      patients with taking 10% of falling risk into consideration. Using Randlist software,
      patients will be randomly assigned to study groups including (A) chest tube drainage and (B)
      needle aspiration. Subsequently, all patients will undergo one-year follow-up and will be
      evaluated in terms of treatment success rate and pneumothorax recurrence.

      In chest tube drainage group, while the patient is positioned in the supine position and
      subsequent to local anesthesia administration via lidocaine 2%, F16 or F20 (based on patients
      physical status) sterile plastic tube will be implemented at the level 4th or 5th intercostal
      space through the midaxillary line. However, in needle aspiration group, patients will be
      positioned semi-supine. Subsequently, G16 intravenous angiocath will be inserted through the
      midclavicular line at the level 2nd or 3rd intercostal space. The catheter needle will be
      removed and catheter will be fixed using sterile sticks. A three-way valve will be connected
      to the external end of the catheter and a 50 ml syringe will be connected to the valve. The
      air suction will be performed using 50 ml syringe till end of the air suction or up to 3.5
      liters of air suctioning.

      Hypothesis of present trial are as follows: a) repetitive needle aspiration may lead to
      higher treatment success rate in patients with primary spontaneous pneumothorax, in
      comparison to chest tube drainage, b) needle aspiration may result in reduction of hospital
      admission duration in patients with primary spontaneous pneumothorax compared to chest tube
      drainage, c) the rate of spontaneous pneumothorax recurrence during one-year follow-up might
      be lower in patients who undergo needle aspiration instead of chest tube drainage.
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: Patients will be randomly and equally assigned to study groups, as follows: group (a) will undergo chest tube drainage implementation and group (b) will undergo repetitive needle aspiration till pnuemothorax resolution.
primary purpose: Treatment
masking: Double (Investigator, Outcomes Assessor)
masking description: Since patients are alert and conscious, therefore we are unable to blind the participants. However, care provider will not take part in the data acquisition and outcome analysis. The investigator and outcome assessor will be blinded to patients allocated group and treatment type provided in each patients.
measure: Pneumothorax recurrence during one-year
time frame: One year postoperative
description: Will be defined as the rate of pneumothorax recurrence until postoperative one-year.
measure: Successful treatment rate
time frame: Postoperative day 1 and postoperative day 7
description: Is defined as completely resolved pneumothorax during admission.
measure: Length of hospital admission
time frame: Through hospital admission, an average of 10 days
description: will be calculated from the time of the operation to time of discharge.
measure: Operation time
time frame: During procedure
description: Will be calculated from the time of skin incision to completing the procedure including complete chest tube insertion in chest tube group or complete air suction or up to 3.5 liters of air suction in needle aspiration group.
measure: Procedure induced complications
time frame: Postoperative day 1, Postoperative day 3, Postoperative day 7, Postoperative month 1,
description: Includes all complications occurred during or after procedure during hospital stay.
measure: Pneumothorax size
time frame: Before procedure, 1 hour after procedure, 48 hours after procedure, one-week after procedure
description: Will be calculated by Light's formula using chest radiography
arm group label: Chest tube drainage
arm group type: Active Comparator
description: This group will undergo chest tube drainage as an intervention for spontaneous pneumothorax treatment.
arm group label: Needle aspiration
arm group type: Active Comparator
description: This group will undergo repetitive needle aspiration as an intervention for spontaneous pneumothorax treatment.
intervention type: Procedure
intervention name: Chest tube drainage
description: In this group, in the supine position and subsequent to prepping and draping and local anesthesia administration via lidocaine 2%, F16 or F20 (based on patients physical status) sterile plastic tube will be implemented at the level 4th or 5th intercostal space through the midaxillary line. Subsequently, the external end of the tube will be connected to water sealing bottle and water bubbles coming out will be considered as proper chest tube insertion.
arm group label: Chest tube drainage
intervention type: Procedure
intervention name: Repetitive needle aspiration
description: In this group, prior to needle aspiration, patients will take the semi-supine position. Subsequent to local anesthesia via lidocaine 2%, as well as prepping and draping, G16 intravenous angiocath will be inserted through midclavicular line at the level 2nd or 3rd intercostal space. Air bubble inside the lidocaine syringe will be considered as needled entrance to pleural cavity, thus 5-10 cm of the angiocath will be import to inside of the cavity. The catheter needle will be removed and catheter will be fixed using sterile sticks. A three-way valve will be connected to external end of the catheter and a 50 ml syringe will be connected to the valve. The air suction will be performed using 50 ml syringe till end of the air suction or up to 3.5 liters of air suctioning.
arm group label: Needle aspiration
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Ali Ramouz
phone: +989399418336
email: ramouza@tbzmed.ac.ir
facility: 
status: Recruiting
contact: 
investigator: 
country: Iran, Islamic Republic of
citation: Tschopp JM, Marquette CH. Spontaneous pneumothorax: stop chest tube as first-line therapy. Eur Respir J. 2017 Apr 12;49(4):1700306. doi: 10.1183/13993003.00306-2017. Print 2017 Apr. No abstract available.
PMID: 28404655
citation: Hu X, Cowl CT, Baqir M, Ryu JH. Air travel and pneumothorax. Chest. 2014 Apr;145(4):688-694. doi: 10.1378/chest.13-2363.
PMID: 24687705
citation: Cran IR, Rumball CA. Survey of spontaneous pneumothoraces in the Royal Air Force. Thorax. 1967 Sep;22(5):462-5. doi: 10.1136/thx.22.5.462.
PMID: 6050294
citation: Harvey J, Prescott RJ. Simple aspiration versus intercostal tube drainage for spontaneous pneumothorax in patients with normal lungs. British Thoracic Society Research Committee. BMJ. 1994 Nov 19;309(6965):1338-9. doi: 10.1136/bmj.309.6965.1338. No abstract available.
PMID: 7755720
citation: Dzeljilji A, Rokicki W, Rokicki M, Karus K. New aspects in the diagnosis and treatment of primary spontaneous pneumothorax. Kardiochir Torakochirurgia Pol. 2017 Mar;14(1):27-31. doi: 10.5114/kitp.2017.66926. Epub 2017 Mar 31.
PMID: 28515745
citation: MacDuff A, Arnold A, Harvey J; BTS Pleural Disease Guideline Group. Management of spontaneous pneumothorax: British Thoracic Society Pleural Disease Guideline 2010. Thorax. 2010 Aug;65 Suppl 2:ii18-31. doi: 10.1136/thx.2010.136986. No abstract available.
PMID: 20696690
citation: Thelle A, Gjerdevik M, SueChu M, Hagen OM, Bakke P. Randomised comparison of needle aspiration and chest tube drainage in spontaneous pneumothorax. Eur Respir J. 2017 Apr 12;49(4):1601296. doi: 10.1183/13993003.01296-2016. Print 2017 Apr.
PMID: 28404647
citation: Tschopp JM, Bintcliffe O, Astoul P, Canalis E, Driesen P, Janssen J, Krasnik M, Maskell N, Van Schil P, Tonia T, Waller DA, Marquette CH, Cardillo G. ERS task force statement: diagnosis and treatment of primary spontaneous pneumothorax. Eur Respir J. 2015 Aug;46(2):321-35. doi: 10.1183/09031936.00219214. Epub 2015 Jun 25.
PMID: 26113675
citation: Wakai A, O'Sullivan RG, McCabe G. Simple aspiration versus intercostal tube drainage for primary spontaneous pneumothorax in adults. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD004479. doi: 10.1002/14651858.CD004479.pub2.
PMID: 17253510
responsible party type: Principal Investigator
investigator affiliation: Tabriz University of Medical Sciences
investigator full name: Ali Ramouz
investigator title: Doctor
mesh term: Pneumothorax
sharing ipd: No