<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03264677</url>
  </required_header>
  <id_info>
    <org_study_id>CO-170223145432-SACT</org_study_id>
    <nct_id>NCT03264677</nct_id>
  </id_info>
  <brief_title>An 8-week Full Face HUT Clinical Trial for HydroBoost (2.0/3.0)</brief_title>
  <official_title>An 8-week Full Face HUT Design, Single Center, Double Blinded, Controlled and Randomized Study to Evaluate Different Product Regimens' Performance on Protecting Skin With Resilience Under Tracked City Environmental Aggressors</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Johnson &amp; Johnson Pte Ltd</agency>
      <agency_class>Industry</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Shanghai Skin Disease Hospital</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Shanghai China-Norm Management Consulting co.,LTD</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Johnson &amp; Johnson Pte Ltd</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      -  To investigate the product regiments' performance on moisturization related skin healthy&#xD;
           signs (skin moisturization, barrier function, elasticity, translucency, roughness and&#xD;
           skin conditions) through instrumental evaluation, clinical grading and self-assessment&#xD;
           before, during and after 8 weeks' home usage under city environmental aggressors (Sun,&#xD;
           change of temperature and humidity, wind and air pollution) among 3 product regimens and&#xD;
           Non-treatment control;&#xD;
&#xD;
        -  To explore the linkage among products efficacy, ambient aggressors, and life habits;&#xD;
&#xD;
        -  To investigate product regimens' tolerance and safety via Home Use Test;&#xD;
&#xD;
        -  To collect skin microflora/microbiome samples for potential research on skin microbiome&#xD;
           distribution change as impacted by product application and/or environmental aggressors&#xD;
           change (data will be analyzed and reported separately).&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      This is a single center, double blinded, controlled and randomized 8-week home use clinical&#xD;
      trial.&#xD;
&#xD;
      Subjects will be randomly and evenly divided into 3 groups (40subjects/group) with different&#xD;
      facial care regimens during the 8-week home use study.&#xD;
&#xD;
      Group 1: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Kiwi Water Gel Group 2: NTG&#xD;
      Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Water Gel Group 3: NTG Hydro Boost Gelee&#xD;
      Milk Cleanser + NTG Hydro Boost Extra Dry Emulsion There will be a 3-day wash-in period after&#xD;
      subject's enrollment. During the period, no product will be allowed to be applied on the face&#xD;
      and upper chest but only water washes twice per day in the morning and evening for 3 days&#xD;
      before baseline (BL) measurement.&#xD;
&#xD;
      After baseline (BL) measurement, the product regimens will be applied on face at site under&#xD;
      site instruction according to the randomization. Measurements will be taken at 2-4 hours and&#xD;
      8 hours after product regimens' application. Upper chest area will be measured as no&#xD;
      treatment control.&#xD;
&#xD;
      A set of product regimen includes a facial cleanser and a facial cream will be distributed to&#xD;
      each subject according to grouping and applied on the face at home for 8 weeks. Both cleanser&#xD;
      and cream products will be applied twice a day in the morning and evening on the whole face.&#xD;
      For the upper chest area, use water wash only twice per day in the morning and evening, no&#xD;
      any other product is allowed.&#xD;
&#xD;
      The usage of assigned product regimens will be discontinued after 8-week home use, no any&#xD;
      other product is allowed but only water wash twice per day in the morning and evening on both&#xD;
      face and upper chest for 3 days (regression period).&#xD;
&#xD;
      Subjects will not be allowed to use sunscreen, makeup and any other cosmetic products on face&#xD;
      and upper chest during the study period.&#xD;
&#xD;
      Subjects will visit the site at Screening (-3D), Baseline (BL), 1-week (1W), 4-week (4W),&#xD;
      8-week (8W) and 8-week+3-days (+3D) for measurements.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">May 18, 2017</start_date>
  <completion_date type="Actual">July 25, 2017</completion_date>
  <primary_completion_date type="Actual">July 25, 2017</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <intervention_model_description>Subjects will be randomly and evenly divided into 3 groups (approx. 40 subjects per group) with different facial care regimens during the 8-week home use study.&#xD;
Group 1: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Kiwi Water Gel Group 2: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Water Gel Group 3: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Extra Dry Emulsion</intervention_model_description>
    <primary_purpose>Other</primary_purpose>
    <masking>Triple (Participant, Investigator, Outcomes Assessor)</masking>
    <masking_description>Since this will be a blind study, the product randomization codes will be generated by study team member different from Study Manager, Study Director, Principle Investigator and any data producers or influencer. The product randomization codes and the corresponding product information (i.e. product name, formula number, batch number, manufacturing/expiry date, etc.) will be sealed in an envelope and before study filed work complete kept by PI until there is a unblinding needs due to medical emergency or report drafting.&#xD;
In this study, in total 4 IPs include 3 facial creams and 1 facial cleanser will be evaluated. Subjects will be assigned to 3 groups randomly and evenly with different facial product regimens (one cleanser + one cream). The product regimens will be applied on the whole face for on-site study and the 8-week HUT. For each subject, left or right cheek area will be randomly chosen as experimental area for evaluation and middle upper chest will be the untreated control area</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Skin surface moisture content</measure>
    <time_frame>9 weeks</time_frame>
    <description>Skin surface moisture content is measured by skin capacitance measurement.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Quality of Life</measure>
    <time_frame>9 weeks</time_frame>
    <description>In this study, an evaluation tool will be used to measure and quantify skin dryness related Quality of Life (QoL) attributes, to get an understanding of the improvement (related to moisturization benefits) after treatment of skin care regimens</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Subject Self-assessment</measure>
    <time_frame>9 weeks</time_frame>
    <description>Subject self-assessment Questionnaire (QN) on product performance</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Temperature</measure>
    <time_frame>9 weeks</time_frame>
    <description>Individual temperature measured by portable environmental tracker</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Humidity</measure>
    <time_frame>9 weeks</time_frame>
    <description>Individual humidity measured by portable environmental tracker</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>PM 2.5</measure>
    <time_frame>9 weeks</time_frame>
    <description>Individual PM 2.5 measured by portable environmental tracker</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin microbiome</measure>
    <time_frame>9 weeks</time_frame>
    <description>To collect skin microflora/microbiome samples for potential research on skin microbiome distribution change as impacted by product application and/or environmental aggressors change.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Life habits</measure>
    <time_frame>9 weeks</time_frame>
    <description>Subject's life pattern captured by diary.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin barrier function</measure>
    <time_frame>9 weeks</time_frame>
    <description>TEWL</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin elasticity</measure>
    <time_frame>9 weeks</time_frame>
    <description>The mechanical property of the epidermis is measured by a non-invasive, in vivo suction skin elasticity meter.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin roughness</measure>
    <time_frame>9 weeks</time_frame>
    <description>Skin roughness measurement via skin surface imaging</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin translucency</measure>
    <time_frame>9 weeks</time_frame>
    <description>Many common materials transmit and scatter light but are neither transparent or opaque. Such materials are described as translucent and the degree of translucency depends on the absorption and scattering coefficients of the material. In this study, the degree of skin translucency is quantified by the rate of lateral scatter of light and the total amount of backscattered light, which captured by a non-invasive Translucency Meter probe.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin deep layer moisture content</measure>
    <time_frame>9 weeks</time_frame>
    <description>Skin deep layer moisture content by measuring skin dielectric constant.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin firmness</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of skin firmness</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin elasticity</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of skin elasticity</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin radiance</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of skin radiance</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin smoothness</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of skin smoothness</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin fine lines</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of skin fine lines</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin softness</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of skin softness</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin hydration</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of skin hydration</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Skin translucency</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of skin translucency</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pimple</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of pimple</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Clogged pores</measure>
    <time_frame>9 weeks</time_frame>
    <description>Dermatologist grading of clogged Pores</description>
  </secondary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Actual">122</enrollment>
  <condition>Adult Skin Healthy Signs</condition>
  <arm_group>
    <arm_group_label>Group 1</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Kiwi Water Gel</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Group 2</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Water Gel</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Group 3</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Extra Dry Emulsion</description>
  </arm_group>
  <intervention>
    <intervention_type>Combination Product</intervention_type>
    <intervention_name>Group 1</intervention_name>
    <description>NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Kiwi Water Gel</description>
    <arm_group_label>Group 1</arm_group_label>
    <other_name>HB Cleanser+Kiwi Water Gel</other_name>
  </intervention>
  <intervention>
    <intervention_type>Combination Product</intervention_type>
    <intervention_name>Group 2</intervention_name>
    <description>NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Water Gel</description>
    <arm_group_label>Group 2</arm_group_label>
    <other_name>HB Cleanser+HB Water Gel</other_name>
  </intervention>
  <intervention>
    <intervention_type>Combination Product</intervention_type>
    <intervention_name>Group 3</intervention_name>
    <description>NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Extra Dry Emulsion</description>
    <arm_group_label>Group 3</arm_group_label>
    <other_name>HB Cleanser+HB ED Emulsion</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria&#xD;
&#xD;
          1. Chinese Females aged 18 - 40 years old in good physical and mental condition;&#xD;
&#xD;
          2. Self-perceived dry facial skin without lesions. Corneometer score ≤35 arbitrary units&#xD;
             on both sides of cheek areas;&#xD;
&#xD;
          3. Having daily routine skin exposure (out-door activities) to city environmental&#xD;
             challenge and having concern on its impact to healthy skin signs (e.g. Smoothness,&#xD;
             Firmness, Translucency, Trouble (pimple, acne) free, Plumpness, etc.);&#xD;
&#xD;
          4. Willing to stay in Shanghai City during the whole study period without travel plan;&#xD;
&#xD;
          5. Having mild to moderate pre-aging sign, e.g. fine line, roughness when skin is dry.&#xD;
             Having skin dullness concern on the face;&#xD;
&#xD;
          6. Non-regular body moisturizer user. Expose the upper-chest site during study;&#xD;
&#xD;
          7. Willing to comply with the study instruction (see Appendix IX);&#xD;
&#xD;
          8. Agree to use only water to wash face and upper chest, avoid using any cosmetic&#xD;
             products (include but not limited to: wash/ soap/ moisturizer/ toner/ sparge/&#xD;
             sunscreen/ oil/ (water) mask/ scrub/ makeup/ fragrance/ light treatment/ massage,&#xD;
             etc.) in the evening before each visit day. No washing on face and upper chest and no&#xD;
             product application at home in the morning of the visit day. Subjects will wash the&#xD;
             test areas when arrive the test site according to the site instruction;&#xD;
&#xD;
          9. After enrollment, there will be a 3-day wash-in period, during which subjects agree to&#xD;
             use water only to wash the face and upper chest twice per day in the morning and&#xD;
             evening. Avoid using any cosmetic products as listed in above item 8 in both test&#xD;
             areas;&#xD;
&#xD;
         10. Then an 8-week home use period will follow, during which subjects agree to use the&#xD;
             assigned product regimens (facial cleanser and facial cream) on face twice per day in&#xD;
             the morning and evening. Use water only to wash the upper chest twice per day in the&#xD;
             morning and evening. Avoid using any cosmetic products as listed in above item 8 in&#xD;
             both test areas;&#xD;
&#xD;
         11. After the 8-week home use of the assigned product regimens, subjects will stop using&#xD;
             the products for 3 days (Regression period). Subjects agree to use water only to wash&#xD;
             the face and upper chest twice per day in the morning and evening during the period.&#xD;
             Avoid using any cosmetic products as listed in above item 8 in both test areas;&#xD;
&#xD;
         12. Generally in good health based on medical history reported by the subject;&#xD;
&#xD;
         13. Female subjects must meet one of the following criteria:&#xD;
&#xD;
               -  Is not of child-bearing potential or is in a monogamous relationship with a&#xD;
                  partner who is not of child-bearing potential, meaning the subject and/or&#xD;
                  partner:&#xD;
&#xD;
                    -  Is post-menopausal (amenorrhea for at least 1 year),&#xD;
&#xD;
                    -  Had a surgical sterilization (e.g., vasectomy that has been confirmed&#xD;
                       effective by sperm count check, tubal occlusion, hysterectomy, bilateral&#xD;
                       oophorectomy or salpingectomy)&#xD;
&#xD;
               -  Must agree to practice a medically acceptable form of birth control during the&#xD;
                  study and for 30 days after study completion. Female subjects must have used such&#xD;
                  birth control for at least 3 months prior to study start. Medically acceptable&#xD;
                  forms of birth control that may be used by the subject and/or partner include:&#xD;
&#xD;
                    -  Established use of hormonal methods of contraception (oral, injected,&#xD;
                       implanted, hormone patch or vaginal ring).&#xD;
&#xD;
                    -  Barrier methods of contraception: condom or occlusive cap (diaphragm or&#xD;
                       cervical/vault caps),&#xD;
&#xD;
                    -  Intrauterine device or intrauterine system,&#xD;
&#xD;
                    -  Abstinence from intercourse that could cause pregnancy. Periodic abstinence&#xD;
                       (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and&#xD;
                       withdrawal are not acceptable methods of contraception.&#xD;
&#xD;
         14. Is not a ward of the court or deprived from liberty by a judiciary or administrative&#xD;
             decision;&#xD;
&#xD;
         15. Able to read, write, speak and understand Chinese language or able to speak and&#xD;
             understand Chinese language and accompanied by an impartial witness who can read,&#xD;
             write, speak and understand Chinese language;&#xD;
&#xD;
         16. Individual that has signed the Consent for Photograph Release (7-8 subjects/group) and&#xD;
             ICD including portable tracker using and reporting as instruction;&#xD;
&#xD;
        Exclusion Criteria&#xD;
&#xD;
          1. Participated in any cosmetic clinical test involving facial and/or body product&#xD;
             application within 3 months before enrollment.&#xD;
&#xD;
          2. Has known allergies or adverse reactions to common topical skincare products;&#xD;
&#xD;
          3. Presents with a skin condition that may influence the outcome of the study (e.g.,&#xD;
             psoriasis, eczema, melanomas), primary/secondary lesions on test sites (e.g. erythema,&#xD;
             scars, ulcers, vesicles);&#xD;
&#xD;
          4. Has a self-reported uncontrolled metabolic condition or disease, such as diabetes,&#xD;
             hypertension, hyper/hypothyroidism, hypercholesterolemia, asthma, epilepsy, etc.&#xD;
             Individuals with a controlled health condition may also be excluded from the study at&#xD;
             the discretion of the PI, if medically qualified, or the designated study physician;&#xD;
&#xD;
          5. Is taking medication for a chronic condition (e.g., insulin, antihistamines, steroidal&#xD;
             and non-steroidal anti-inflammatory drugs, antibiotics, etc.) or is taking any other&#xD;
             medication that could influence the study results and/or affect the individual's&#xD;
             safety, within 30 days before inclusion or during the study;&#xD;
&#xD;
          6. Is taking immunosuppressive drugs within 3 months before inclusion and during the&#xD;
             study;&#xD;
&#xD;
          7. Has a history of or concurrent health condition/situation which, in the opinion of the&#xD;
             PI, if medically qualified, or the designated study physician, may put the individual&#xD;
             at significant risk, confound the study results, or interfere significantly with the&#xD;
             individual's participation in the study;&#xD;
&#xD;
          8. Is simultaneously participating in any other type of clinical study;&#xD;
&#xD;
          9. Is an employee/contractor or immediate family member of the PI, Study Site staff or&#xD;
             Sponsor.&#xD;
      </textblock>
    </criteria>
    <gender>Female</gender>
    <gender_based>Yes</gender_based>
    <gender_description>Chinese Females</gender_description>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>40 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Chao Yuan</last_name>
    <role>Principal Investigator</role>
    <affiliation>Shanghai Skin Disease Hospital</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Shanghai Skin Disease Hospital</name>
      <address>
        <city>Shanghai</city>
        <state>Shanghai</state>
        <zip>200443</zip>
        <country>China</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
  <link>
    <url>http://filehosting.pharmacm.com/DownloadService.ashx?client=CTR_JNJ_7051&amp;studyid=12414&amp;filename=Report%20synopsis%20of%20HB%208-week%20HUT.pdf</url>
    <description>Related Info</description>
  </link>
  <verification_date>April 2018</verification_date>
  <study_first_submitted>July 24, 2017</study_first_submitted>
  <study_first_submitted_qc>August 24, 2017</study_first_submitted_qc>
  <study_first_posted type="Actual">August 29, 2017</study_first_posted>
  <last_update_submitted>April 10, 2018</last_update_submitted>
  <last_update_submitted_qc>April 10, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">April 11, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>8-week HUT</keyword>
  <keyword>Hydro Boost</keyword>
  <keyword>Skin healthy signs</keyword>
  <keyword>Environmental aggressors</keyword>
  <keyword>Cosmetic</keyword>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03264677
org study id: CO-170223145432-SACT
nct id: NCT03264677
lead sponsor: 
collaborator: 
collaborator: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
-  To investigate the product regiments' performance on moisturization related skin healthy
           signs (skin moisturization, barrier function, elasticity, translucency, roughness and
           skin conditions) through instrumental evaluation, clinical grading and self-assessment
           before, during and after 8 weeks' home usage under city environmental aggressors (Sun,
           change of temperature and humidity, wind and air pollution) among 3 product regimens and
           Non-treatment control;

        -  To explore the linkage among products efficacy, ambient aggressors, and life habits;

        -  To investigate product regimens' tolerance and safety via Home Use Test;

        -  To collect skin microflora/microbiome samples for potential research on skin microbiome
           distribution change as impacted by product application and/or environmental aggressors
           change (data will be analyzed and reported separately).
This is a single center, double blinded, controlled and randomized 8-week home use clinical
      trial.

      Subjects will be randomly and evenly divided into 3 groups (40subjects/group) with different
      facial care regimens during the 8-week home use study.

      Group 1: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Kiwi Water Gel Group 2: NTG
      Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Water Gel Group 3: NTG Hydro Boost Gelee
      Milk Cleanser + NTG Hydro Boost Extra Dry Emulsion There will be a 3-day wash-in period after
      subject's enrollment. During the period, no product will be allowed to be applied on the face
      and upper chest but only water washes twice per day in the morning and evening for 3 days
      before baseline (BL) measurement.

      After baseline (BL) measurement, the product regimens will be applied on face at site under
      site instruction according to the randomization. Measurements will be taken at 2-4 hours and
      8 hours after product regimens' application. Upper chest area will be measured as no
      treatment control.

      A set of product regimen includes a facial cleanser and a facial cream will be distributed to
      each subject according to grouping and applied on the face at home for 8 weeks. Both cleanser
      and cream products will be applied twice a day in the morning and evening on the whole face.
      For the upper chest area, use water wash only twice per day in the morning and evening, no
      any other product is allowed.

      The usage of assigned product regimens will be discontinued after 8-week home use, no any
      other product is allowed but only water wash twice per day in the morning and evening on both
      face and upper chest for 3 days (regression period).

      Subjects will not be allowed to use sunscreen, makeup and any other cosmetic products on face
      and upper chest during the study period.

      Subjects will visit the site at Screening (-3D), Baseline (BL), 1-week (1W), 4-week (4W),
      8-week (8W) and 8-week+3-days (+3D) for measurements.
allocation: Randomized
intervention model: Parallel Assignment
intervention model description: Subjects will be randomly and evenly divided into 3 groups (approx. 40 subjects per group) with different facial care regimens during the 8-week home use study.
Group 1: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Kiwi Water Gel Group 2: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Water Gel Group 3: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Extra Dry Emulsion
primary purpose: Other
masking: Triple (Participant, Investigator, Outcomes Assessor)
masking description: Since this will be a blind study, the product randomization codes will be generated by study team member different from Study Manager, Study Director, Principle Investigator and any data producers or influencer. The product randomization codes and the corresponding product information (i.e. product name, formula number, batch number, manufacturing/expiry date, etc.) will be sealed in an envelope and before study filed work complete kept by PI until there is a unblinding needs due to medical emergency or report drafting.
In this study, in total 4 IPs include 3 facial creams and 1 facial cleanser will be evaluated. Subjects will be assigned to 3 groups randomly and evenly with different facial product regimens (one cleanser + one cream). The product regimens will be applied on the whole face for on-site study and the 8-week HUT. For each subject, left or right cheek area will be randomly chosen as experimental area for evaluation and middle upper chest will be the untreated control area
measure: Skin surface moisture content
time frame: 9 weeks
description: Skin surface moisture content is measured by skin capacitance measurement.
measure: Quality of Life
time frame: 9 weeks
description: In this study, an evaluation tool will be used to measure and quantify skin dryness related Quality of Life (QoL) attributes, to get an understanding of the improvement (related to moisturization benefits) after treatment of skin care regimens
measure: Subject Self-assessment
time frame: 9 weeks
description: Subject self-assessment Questionnaire (QN) on product performance
measure: Temperature
time frame: 9 weeks
description: Individual temperature measured by portable environmental tracker
measure: Humidity
time frame: 9 weeks
description: Individual humidity measured by portable environmental tracker
measure: PM 2.5
time frame: 9 weeks
description: Individual PM 2.5 measured by portable environmental tracker
measure: Skin microbiome
time frame: 9 weeks
description: To collect skin microflora/microbiome samples for potential research on skin microbiome distribution change as impacted by product application and/or environmental aggressors change.
measure: Life habits
time frame: 9 weeks
description: Subject's life pattern captured by diary.
measure: Skin barrier function
time frame: 9 weeks
description: TEWL
measure: Skin elasticity
time frame: 9 weeks
description: The mechanical property of the epidermis is measured by a non-invasive, in vivo suction skin elasticity meter.
measure: Skin roughness
time frame: 9 weeks
description: Skin roughness measurement via skin surface imaging
measure: Skin translucency
time frame: 9 weeks
description: Many common materials transmit and scatter light but are neither transparent or opaque. Such materials are described as translucent and the degree of translucency depends on the absorption and scattering coefficients of the material. In this study, the degree of skin translucency is quantified by the rate of lateral scatter of light and the total amount of backscattered light, which captured by a non-invasive Translucency Meter probe.
measure: Skin deep layer moisture content
time frame: 9 weeks
description: Skin deep layer moisture content by measuring skin dielectric constant.
measure: Skin firmness
time frame: 9 weeks
description: Dermatologist grading of skin firmness
measure: Skin elasticity
time frame: 9 weeks
description: Dermatologist grading of skin elasticity
measure: Skin radiance
time frame: 9 weeks
description: Dermatologist grading of skin radiance
measure: Skin smoothness
time frame: 9 weeks
description: Dermatologist grading of skin smoothness
measure: Skin fine lines
time frame: 9 weeks
description: Dermatologist grading of skin fine lines
measure: Skin softness
time frame: 9 weeks
description: Dermatologist grading of skin softness
measure: Skin hydration
time frame: 9 weeks
description: Dermatologist grading of skin hydration
measure: Skin translucency
time frame: 9 weeks
description: Dermatologist grading of skin translucency
measure: Pimple
time frame: 9 weeks
description: Dermatologist grading of pimple
measure: Clogged pores
time frame: 9 weeks
description: Dermatologist grading of clogged Pores
arm group label: Group 1
arm group type: Experimental
description: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Kiwi Water Gel
arm group label: Group 2
arm group type: Experimental
description: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Water Gel
arm group label: Group 3
arm group type: Experimental
description: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Extra Dry Emulsion
intervention type: Combination Product
intervention name: Group 1
description: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Kiwi Water Gel
arm group label: Group 1
other name: HB Cleanser+Kiwi Water Gel
intervention type: Combination Product
intervention name: Group 2
description: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Water Gel
arm group label: Group 2
other name: HB Cleanser+HB Water Gel
intervention type: Combination Product
intervention name: Group 3
description: NTG Hydro Boost Gelee Milk Cleanser + NTG Hydro Boost Extra Dry Emulsion
arm group label: Group 3
other name: HB Cleanser+HB ED Emulsion
criteria: 
gender: Female
gender based: Yes
gender description: Chinese Females
minimum age: 18 Years
maximum age: 40 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Chao Yuan
role: Principal Investigator
affiliation: Shanghai Skin Disease Hospital
facility: 
country: China
url: http://filehosting.pharmacm.com/DownloadService.ashx?client=CTR_JNJ_7051&studyid=12414&filename=Report%20synopsis%20of%20HB%208-week%20HUT.pdf
description: Related Info
responsible party type: Sponsor
sharing ipd: No