<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02984904</url>
  </required_header>
  <id_info>
    <org_study_id>MMG-FUS-2015-01</org_study_id>
    <nct_id>NCT02984904</nct_id>
  </id_info>
  <brief_title>Fusarium Keratitits in Spain 2012 to 2014</brief_title>
  <official_title>Multicenter Study About Fusarium Keratitits in Spain 2012 to 2014</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Miguel Armando Mosquera Gordillo, MD</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Complejo Hospitalario de Navarra</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The aim of this study was to describe the clinical-epidemiological characteristics of a&#xD;
      series of cases of fungal keratitis associated with Fusarium spp., In Spain during the years&#xD;
      2012 to 2014.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Corneal ulcers are the second cause of preventable blindness in tropical countries, which are&#xD;
      produced by a wide variety of eye infections that can lead to visual impairment, As a&#xD;
      consequence of the cicatrization of the lesions caused. The World Health Organization (WHO)&#xD;
      estimates that around 1.5-2.0 million new cases of monocular blindness secondary to this type&#xD;
      of lesions occur every year.&#xD;
&#xD;
      Corneal ulceration is attributed to mycotic aetiology between 6 and 53% of the cases,&#xD;
      recognising at least 70 different genera. Studies in developing countries have reported the&#xD;
      presence of a wide variety of pathogenic fungi isolated from corneal ulcers, most prominently&#xD;
      highlighting Candida spp. And Aspergillus spp., however, the appearance of less common fungal&#xD;
      pathogens, but of great medical importance, owing to increased morbidity in healthy patients&#xD;
      and especially in the immunocompromised population. These pathogens include the filamentous&#xD;
      fungi Fusarium spp.&#xD;
&#xD;
      Fusarium spp. Is a universally distributed opportunistic fungus, ubiquitous and of great&#xD;
      economic importance because it is usually phytopathogenic. This fungus causes human&#xD;
      infections such as keratitis, endophthalmitis, among others. A predisposing factor for&#xD;
      Fusarium spp. Is the corneal trauma, with an incidence ranging from 7% to 89.9%. Some&#xD;
      research shows that these lesions were caused by different agents, it includes plant material&#xD;
      (rice, hawthorn, hay, among others), animal (insects, cat scratch, among others), dust,&#xD;
      earth, mud, stones, glass, metal objects and nails. Other factors that affect the appearance&#xD;
      of keratitis by this type of fungus include the use of topical corticosteroids, previous eye&#xD;
      surgery, pre-existing eye diseases (lagophthalmos, chronic dacryocystitis, corneal scarring&#xD;
      or corneal ulcer), systemic diseases such as diabetes mellitus, leprosy, among others. These&#xD;
      mycotic infections tend to be resistant to conventional antifungal agents, presenting more&#xD;
      severe complications than other types of infections.&#xD;
&#xD;
      The epidemiological pattern of Fusarium spp. keratitis varies from country to country,&#xD;
      predominating in regions that share climatic conditions, as described in Florida, Ghana, and&#xD;
      China. Even in one country, its distribution is not homogeneous, as evidenced by studies in&#xD;
      southern India, between the years 1991 to 2000, where 1360 mycotic keratitis was present, 506&#xD;
      (37.2%) attributed to Fusarium spp. By contrast, a study conducted in northern India over 6&#xD;
      years found 61 cases of mycotic keratitis, 10 of them (16.4%) secondary to Fusarium spp.&#xD;
&#xD;
      In June 2006, the Centers for Disease Control and Prevention (CDC) confirmed an outbreak of&#xD;
      Fusarium spp., In 164 patients with contact lenses in 33 states and 1 US territory, being the&#xD;
      most important outbreak reported in this country.&#xD;
&#xD;
      The keratitis caused by Fusarium spp. Occurs infrequently in European countries with&#xD;
      temperate climates. A study conducted in Paris between 1993 and 2001 reported 19 mycotic&#xD;
      keratitis, 4 cases (21%) attributed to Fusarium spp.&#xD;
&#xD;
      In Spain, it has been realised clinical case studies of Fusarium spp, however, no&#xD;
      descriptions of the epidemiological profile have been made.The aim of this study was to&#xD;
      describe the clinical-epidemiological characteristics of a series of cases of fungal&#xD;
      keratitis associated with Fusarium spp., In Spain during the years 2012 to 2014.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date>April 2015</start_date>
  <completion_date type="Actual">August 2016</completion_date>
  <primary_completion_date type="Actual">November 2015</primary_completion_date>
  <study_type>Observational [Patient Registry]</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <time_perspective>Cross-Sectional</time_perspective>
  </study_design_info>
  <target_duration>1 Day</target_duration>
  <primary_outcome>
    <measure>Describe the clinical-epidemiological characteristics of a series of cases of fungal keratitis associated with Fusarium spp</measure>
    <time_frame>2012 to 2014</time_frame>
    <description>epidemiological survey</description>
  </primary_outcome>
  <enrollment type="Actual">23</enrollment>
  <condition>Corneal Ulcer</condition>
  <condition>Fusarium Infection</condition>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>survey</intervention_name>
    <description>survey</description>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        Person diagnosed with keratitis secondary to Fusarium spp., During the study period&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria: Growth in the microbiological culture of Fusarium spp. In ocular&#xD;
        samples informed by the participating centers confirmed or not by the National Center of&#xD;
        Microbiology of the Carlos III Health Institute (ISC III) of Spain, admitting only one&#xD;
        registry per patient / year -&#xD;
&#xD;
        Exclusion Criteria: Patients who could not be contacted because they did not reside in&#xD;
        Spain or who did not accept the same&#xD;
&#xD;
        -&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>100 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>José Larmarca Mateu, MD</last_name>
    <role>Study Chair</role>
    <affiliation>CLINICA BARRAQUER</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Tomas Marti Huguet, MD</last_name>
    <role>Study Chair</role>
    <affiliation>HOSPITAL BELLVITGE</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Sara Martin, MD</last_name>
    <role>Study Chair</role>
    <affiliation>HOSPITAL UNIVERSITARIO VALL DE HEBRON</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Paula Marticorena Alvarez, MD</last_name>
    <role>Study Chair</role>
    <affiliation>Hospital Universitario La Princesa</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Andres Garralda Luquin, MD</last_name>
    <role>Study Chair</role>
    <affiliation>Complejo Hospitalario de Navarra</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Carlos Lopez Gutierrez, MD</last_name>
    <role>Study Chair</role>
    <affiliation>HOSPITAL GALDAKAO</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Jesus Garrido Fierro, MD</last_name>
    <role>Study Chair</role>
    <affiliation>HOSPITAL TXAGORRITXU - HOSPITAL UNIVERSITARIO ARABA</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Raquel Feijó Lera, MD</last_name>
    <role>Study Chair</role>
    <affiliation>HOSPITAL LAS CRUCES</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Juan Carlos Sanchez España, MD</last_name>
    <role>Study Chair</role>
    <affiliation>HOSPITAL GENERAL JUAN RAMÓN JIMENEZ</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Graciela Trujillo, MD</last_name>
    <role>Study Chair</role>
    <affiliation>HOSPITAL DOCTOR NEGRIN</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Encarnacio Mengual Verdu, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Hospital Universitario San Juan de Alicante</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Victor Garcia, MD</last_name>
    <role>Study Chair</role>
    <affiliation>Hospital Universitario San Juan de Alicante</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Miguel A Mosquera Gordillo, MD</last_name>
    <role>Study Director</role>
    <affiliation>Hospital Universitario San Juan de Alicante</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Natalia Baron Cano, Nurse</last_name>
    <role>Study Chair</role>
    <affiliation>Miguel Hernandez University (MPH)</affiliation>
  </overall_official>
  <link>
    <url>http://www.nepjol.info/index.php/NJMS/article/view/7651</url>
    <description>Spectrum of Mycotic corneal ulcers in Mid Western peripheral region of Terrain belt of Nepal and Indo-Nepal Border</description>
  </link>
  <link>
    <url>http://www.oftalmo.com/sco/revista-21/21sco06.htm</url>
    <description>Queratitis micótica. Caso clínico. Arch Soc Canar Oftal [Internet]. 2006;17</description>
  </link>
  <link>
    <url>http://www.oftalmo.com/sco/revista-21/21sco06.htm</url>
    <description>Queratitis por Fusarium. A propósito de dos casos. Arch Soc Canar Oftal [Internet]. 2010;21</description>
  </link>
  <results_reference>
    <citation>Upadhyay MP, Karmacharya PC, Koirala S, Tuladhar NR, Bryan LE, Smolin G, Whitcher JP. Epidemiologic characteristics, predisposing factors, and etiologic diagnosis of corneal ulceration in Nepal. Am J Ophthalmol. 1991 Jan 15;111(1):92-9. doi: 10.1016/s0002-9394(14)76903-x.</citation>
    <PMID>1985498</PMID>
  </results_reference>
  <results_reference>
    <citation>Ahearn DG, Zhang S, Stulting RD, Schwam BL, Simmons RB, Ward MA, Pierce GE, Crow SA Jr. Fusarium keratitis and contact lens wear: facts and speculations. Med Mycol. 2008 Aug;46(5):397-410. doi: 10.1080/13693780801961352. Epub 2008 Apr 4.</citation>
    <PMID>18608899</PMID>
  </results_reference>
  <results_reference>
    <citation>Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: a global perspective. Bull World Health Organ. 2001;79(3):214-21. Epub 2003 Jul 7.</citation>
    <PMID>11285665</PMID>
  </results_reference>
  <results_reference>
    <citation>Srinivasan M, Gonzales CA, George C, Cevallos V, Mascarenhas JM, Asokan B, Wilkins J, Smolin G, Whitcher JP. Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, south India. Br J Ophthalmol. 1997 Nov;81(11):965-71. doi: 10.1136/bjo.81.11.965.</citation>
    <PMID>9505820</PMID>
  </results_reference>
  <results_reference>
    <citation>Bharathi MJ, Ramakrishnan R, Vasu S; Meenakshi; Palaniappan R. Aetiological diagnosis of microbial keratitis in South India - a study of 1618 cases. Indian J Med Microbiol. 2002 Jan-Mar;20(1):19-24.</citation>
    <PMID>17657018</PMID>
  </results_reference>
  <results_reference>
    <citation>Gopinathan U, Garg P, Fernandes M, Sharma S, Athmanathan S, Rao GN. The epidemiological features and laboratory results of fungal keratitis: a 10-year review at a referral eye care center in South India. Cornea. 2002 Aug;21(6):555-9. doi: 10.1097/00003226-200208000-00004.</citation>
    <PMID>12131029</PMID>
  </results_reference>
  <results_reference>
    <citation>Basak SK, Basak S, Mohanta A, Bhowmick A. Epidemiological and microbiological diagnosis of suppurative keratitis in Gangetic West Bengal, eastern India. Indian J Ophthalmol. 2005 Mar;53(1):17-22. doi: 10.4103/0301-4738.15280.</citation>
    <PMID>15829742</PMID>
  </results_reference>
  <results_reference>
    <citation>Norina TJ, Raihan S, Bakiah S, Ezanee M, Liza-Sharmini AT, Wan Hazzabah WH. Microbial keratitis: aetiological diagnosis and clinical features in patients admitted to Hospital Universiti Sains Malaysia. Singapore Med J. 2008 Jan;49(1):67-71.</citation>
    <PMID>18204773</PMID>
  </results_reference>
  <results_reference>
    <citation>Doczi I, Gyetvai T, Kredics L, Nagy E. Involvement of Fusarium spp. in fungal keratitis. Clin Microbiol Infect. 2004 Sep;10(9):773-6. doi: 10.1111/j.1469-0691.2004.00909.x.</citation>
    <PMID>15355406</PMID>
  </results_reference>
  <results_reference>
    <citation>Tanure MA, Cohen EJ, Sudesh S, Rapuano CJ, Laibson PR. Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania. Cornea. 2000 May;19(3):307-12. doi: 10.1097/00003226-200005000-00010.</citation>
    <PMID>10832689</PMID>
  </results_reference>
  <results_reference>
    <citation>Passos RM, Cariello AJ, Yu MC, Hofling-Lima AL. Microbial keratitis in the elderly: a 32-year review. Arq Bras Oftalmol. 2010 Jul-Aug;73(4):315-9. doi: 10.1590/s0004-27492010000400002.</citation>
    <PMID>20944931</PMID>
  </results_reference>
  <results_reference>
    <citation>Saha R, Das S. Mycological profile of infectious Keratitis from Delhi. Indian J Med Res. 2006 Feb;123(2):159-64.</citation>
    <PMID>16575115</PMID>
  </results_reference>
  <results_reference>
    <citation>Nath R, Baruah S, Saikia L, Devi B, Borthakur AK, Mahanta J. Mycotic corneal ulcers in upper Assam. Indian J Ophthalmol. 2011 Sep-Oct;59(5):367-71. doi: 10.4103/0301-4738.83613.</citation>
    <PMID>21836342</PMID>
  </results_reference>
  <results_reference>
    <citation>Green M, Apel A, Stapleton F. Risk factors and causative organisms in microbial keratitis. Cornea. 2008 Jan;27(1):22-7. doi: 10.1097/ICO.0b013e318156caf2.</citation>
    <PMID>18245962</PMID>
  </results_reference>
  <results_reference>
    <citation>Leck AK, Thomas PA, Hagan M, Kaliamurthy J, Ackuaku E, John M, Newman MJ, Codjoe FS, Opintan JA, Kalavathy CM, Essuman V, Jesudasan CA, Johnson GJ. Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis. Br J Ophthalmol. 2002 Nov;86(11):1211-5. doi: 10.1136/bjo.86.11.1211.</citation>
    <PMID>12386069</PMID>
  </results_reference>
  <results_reference>
    <citation>Rosa RH Jr, Miller D, Alfonso EC. The changing spectrum of fungal keratitis in south Florida. Ophthalmology. 1994 Jun;101(6):1005-13. doi: 10.1016/s0161-6420(94)31225-5.</citation>
    <PMID>8008340</PMID>
  </results_reference>
  <results_reference>
    <citation>Xie L, Dong X, Shi W. Treatment of fungal keratitis by penetrating keratoplasty. Br J Ophthalmol. 2001 Sep;85(9):1070-4. doi: 10.1136/bjo.85.9.1070.</citation>
    <PMID>11520759</PMID>
  </results_reference>
  <results_reference>
    <citation>Chander J, Sharma A. Prevalence of fungal corneal ulcers in northern India. Infection. 1994 May-Jun;22(3):207-9. doi: 10.1007/BF01716706.</citation>
    <PMID>7927819</PMID>
  </results_reference>
  <results_reference>
    <citation>Chang DC, Grant GB, O'Donnell K, Wannemuehler KA, Noble-Wang J, Rao CY, Jacobson LM, Crowell CS, Sneed RS, Lewis FM, Schaffzin JK, Kainer MA, Genese CA, Alfonso EC, Jones DB, Srinivasan A, Fridkin SK, Park BJ; Fusarium Keratitis Investigation Team. Multistate outbreak of Fusarium keratitis associated with use of a contact lens solution. JAMA. 2006 Aug 23;296(8):953-63. doi: 10.1001/jama.296.8.953.</citation>
    <PMID>16926355</PMID>
  </results_reference>
  <results_reference>
    <citation>Rondeau N, Bourcier T, Chaumeil C, Borderie V, Touzeau O, Scat Y, Thomas F, Baudouin C, Nordmann JP, Laroche L. [Fungal keratitis at the Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts: retrospective study of 19 cases]. J Fr Ophtalmol. 2002 Nov;25(9):890-6. French.</citation>
    <PMID>12515932</PMID>
  </results_reference>
  <results_reference>
    <citation>Donnio A, Van Nuoi DN, Catanese M, Desbois N, Ayeboua L, Merle H. Outbreak of keratomycosis attributable to Fusarium solani in the French West Indies. Am J Ophthalmol. 2007 Feb;143(2):356-8. doi: 10.1016/j.ajo.2006.09.021. Epub 2006 Oct 20.</citation>
    <PMID>17258535</PMID>
  </results_reference>
  <verification_date>November 2016</verification_date>
  <study_first_submitted>November 17, 2016</study_first_submitted>
  <study_first_submitted_qc>December 2, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">December 7, 2016</study_first_posted>
  <last_update_submitted>December 2, 2016</last_update_submitted>
  <last_update_submitted_qc>December 2, 2016</last_update_submitted_qc>
  <last_update_posted type="Estimate">December 7, 2016</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana</investigator_affiliation>
    <investigator_full_name>Miguel Armando Mosquera Gordillo, MD</investigator_full_name>
    <investigator_title>MD</investigator_title>
  </responsible_party>
  <keyword>Fusarium Infection</keyword>
  <keyword>Corneal ulcer</keyword>
  <keyword>Spain</keyword>
  <keyword>Epidemiology</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Corneal Ulcer</mesh_term>
    <mesh_term>Fusariosis</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02984904
org study id: MMG-FUS-2015-01
nct id: NCT02984904
lead sponsor: 
collaborator: 
has dmc: Yes
The aim of this study was to describe the clinical-epidemiological characteristics of a
      series of cases of fungal keratitis associated with Fusarium spp., In Spain during the years
      2012 to 2014.
Corneal ulcers are the second cause of preventable blindness in tropical countries, which are
      produced by a wide variety of eye infections that can lead to visual impairment, As a
      consequence of the cicatrization of the lesions caused. The World Health Organization (WHO)
      estimates that around 1.5-2.0 million new cases of monocular blindness secondary to this type
      of lesions occur every year.

      Corneal ulceration is attributed to mycotic aetiology between 6 and 53% of the cases,
      recognising at least 70 different genera. Studies in developing countries have reported the
      presence of a wide variety of pathogenic fungi isolated from corneal ulcers, most prominently
      highlighting Candida spp. And Aspergillus spp., however, the appearance of less common fungal
      pathogens, but of great medical importance, owing to increased morbidity in healthy patients
      and especially in the immunocompromised population. These pathogens include the filamentous
      fungi Fusarium spp.

      Fusarium spp. Is a universally distributed opportunistic fungus, ubiquitous and of great
      economic importance because it is usually phytopathogenic. This fungus causes human
      infections such as keratitis, endophthalmitis, among others. A predisposing factor for
      Fusarium spp. Is the corneal trauma, with an incidence ranging from 7% to 89.9%. Some
      research shows that these lesions were caused by different agents, it includes plant material
      (rice, hawthorn, hay, among others), animal (insects, cat scratch, among others), dust,
      earth, mud, stones, glass, metal objects and nails. Other factors that affect the appearance
      of keratitis by this type of fungus include the use of topical corticosteroids, previous eye
      surgery, pre-existing eye diseases (lagophthalmos, chronic dacryocystitis, corneal scarring
      or corneal ulcer), systemic diseases such as diabetes mellitus, leprosy, among others. These
      mycotic infections tend to be resistant to conventional antifungal agents, presenting more
      severe complications than other types of infections.

      The epidemiological pattern of Fusarium spp. keratitis varies from country to country,
      predominating in regions that share climatic conditions, as described in Florida, Ghana, and
      China. Even in one country, its distribution is not homogeneous, as evidenced by studies in
      southern India, between the years 1991 to 2000, where 1360 mycotic keratitis was present, 506
      (37.2%) attributed to Fusarium spp. By contrast, a study conducted in northern India over 6
      years found 61 cases of mycotic keratitis, 10 of them (16.4%) secondary to Fusarium spp.

      In June 2006, the Centers for Disease Control and Prevention (CDC) confirmed an outbreak of
      Fusarium spp., In 164 patients with contact lenses in 33 states and 1 US territory, being the
      most important outbreak reported in this country.

      The keratitis caused by Fusarium spp. Occurs infrequently in European countries with
      temperate climates. A study conducted in Paris between 1993 and 2001 reported 19 mycotic
      keratitis, 4 cases (21%) attributed to Fusarium spp.

      In Spain, it has been realised clinical case studies of Fusarium spp, however, no
      descriptions of the epidemiological profile have been made.The aim of this study was to
      describe the clinical-epidemiological characteristics of a series of cases of fungal
      keratitis associated with Fusarium spp., In Spain during the years 2012 to 2014.
time perspective: Cross-Sectional
measure: Describe the clinical-epidemiological characteristics of a series of cases of fungal keratitis associated with Fusarium spp
time frame: 2012 to 2014
description: epidemiological survey
intervention type: Other
intervention name: survey
description: survey
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: 100 Years
healthy volunteers: No
last name: José Larmarca Mateu, MD
role: Study Chair
affiliation: CLINICA BARRAQUER
last name: Tomas Marti Huguet, MD
role: Study Chair
affiliation: HOSPITAL BELLVITGE
last name: Sara Martin, MD
role: Study Chair
affiliation: HOSPITAL UNIVERSITARIO VALL DE HEBRON
last name: Paula Marticorena Alvarez, MD
role: Study Chair
affiliation: Hospital Universitario La Princesa
last name: Andres Garralda Luquin, MD
role: Study Chair
affiliation: Complejo Hospitalario de Navarra
last name: Carlos Lopez Gutierrez, MD
role: Study Chair
affiliation: HOSPITAL GALDAKAO
last name: Jesus Garrido Fierro, MD
role: Study Chair
affiliation: HOSPITAL TXAGORRITXU - HOSPITAL UNIVERSITARIO ARABA
last name: Raquel Feijó Lera, MD
role: Study Chair
affiliation: HOSPITAL LAS CRUCES
last name: Juan Carlos Sanchez España, MD
role: Study Chair
affiliation: HOSPITAL GENERAL JUAN RAMÓN JIMENEZ
last name: Graciela Trujillo, MD
role: Study Chair
affiliation: HOSPITAL DOCTOR NEGRIN
last name: Encarnacio Mengual Verdu, MD
role: Principal Investigator
affiliation: Hospital Universitario San Juan de Alicante
last name: Victor Garcia, MD
role: Study Chair
affiliation: Hospital Universitario San Juan de Alicante
last name: Miguel A Mosquera Gordillo, MD
role: Study Director
affiliation: Hospital Universitario San Juan de Alicante
last name: Natalia Baron Cano, Nurse
role: Study Chair
affiliation: Miguel Hernandez University (MPH)
url: http://www.nepjol.info/index.php/NJMS/article/view/7651
description: Spectrum of Mycotic corneal ulcers in Mid Western peripheral region of Terrain belt of Nepal and Indo-Nepal Border
url: http://www.oftalmo.com/sco/revista-21/21sco06.htm
description: Queratitis micótica. Caso clínico. Arch Soc Canar Oftal [Internet]. 2006;17
url: http://www.oftalmo.com/sco/revista-21/21sco06.htm
description: Queratitis por Fusarium. A propósito de dos casos. Arch Soc Canar Oftal [Internet]. 2010;21
citation: Upadhyay MP, Karmacharya PC, Koirala S, Tuladhar NR, Bryan LE, Smolin G, Whitcher JP. Epidemiologic characteristics, predisposing factors, and etiologic diagnosis of corneal ulceration in Nepal. Am J Ophthalmol. 1991 Jan 15;111(1):92-9. doi: 10.1016/s0002-9394(14)76903-x.
PMID: 1985498
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responsible party type: Sponsor-Investigator
investigator affiliation: Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
investigator full name: Miguel Armando Mosquera Gordillo, MD
investigator title: MD
mesh term: Corneal Ulcer
mesh term: Fusariosis
sharing ipd: Undecided