<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02985112</url>
  </required_header>
  <id_info>
    <org_study_id>USL9-2015-007-NIRS</org_study_id>
    <nct_id>NCT02985112</nct_id>
  </id_info>
  <brief_title>INTegrated Assessment of intERmediate Coronary Stenoses by Fractional Flow rEserve (FFR) and Near-infraREd Spectroscopy (NIRS)</brief_title>
  <acronym>INTERFERE</acronym>
  <official_title>INTegrated Assessment of intERmediate Coronary Stenoses by Fractional Flow rEserve (FFR) and Near-infraREd Spectroscopy (NIRS).</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>S.M. Misericordia Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>San Giovanni Addolorata Hospital</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>S.M. Misericordia Hospital</source>
  <brief_summary>
    <textblock>
      Revascularization of borderline coronary stenoses (40-70%) is usually driven by fractional&#xD;
      flow reserve (FFR) which expresses the physiological significance of a lesion and tells the&#xD;
      operator whether PCI may reduce the rate of adverse events as compared to medical therapy.&#xD;
      Coronary stenoses with FFR value &lt; 0.80 are indeed associated with a higher rate of adverse&#xD;
      event and requires coronary revascularization whereas lesions with FFR &gt; 0.80 show an&#xD;
      excellent prognosis which cannot be improved by coronary stenting. Such a predictive value of&#xD;
      FFR is theoretically based only on the degree of myocardial ischemia downstream from a given&#xD;
      coronary stenosis: however, also plaque composition may play a crucial role in triggering&#xD;
      future events especially in patients affected by acute coronary syndrome. Differences in&#xD;
      plaque composition between FFR-positive and FFR negative lesions have never been assessed.&#xD;
      Intracoronary Near-InfraRed Spectroscopy (NIRS) identifies lipid rich plaques that can&#xD;
      potentially cause acute events. The aim of this study is to compare the lipid content&#xD;
      expressed by LCBI (Lipid Core Burden Index) between functionally significant (FFR &lt; 0.80) and&#xD;
      non-significant (FFR &gt; 0.80) stenoses in patients undergoing coronary angiography because of&#xD;
      stable CAD and non-ST elevation acute coronary syndromes. This is an observational,&#xD;
      prospective, multicentric study where we plan to collect 150 coronary lesions.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Background Objective of percutaneous coronary intervention (PCI) is the treatment of&#xD;
      angiographically significant coronary stenoses in patients affected by stable or unstable&#xD;
      coronary syndromes 1. When we face an intermediate stenosis (percentage diameter stenosis&#xD;
      between 40% and 70%), revascularization is guided by the presence of inducible myocardial&#xD;
      ischemia, detected by non - invasive stress tests or by assessment of fractional flow reserve&#xD;
      (FFR). FFR is an index of the physiological significance of a coronary stenosis and is&#xD;
      defined as the ratio of maximal blood flow in a stenotic artery to normal maximal flow. An&#xD;
      FFR value of 0.80 or less identifies ischemia-causing coronary stenoses with an accuracy of&#xD;
      more than 90%. FFR is a very accurate tool to identify functionally significant stenoses and&#xD;
      to predict cardiovascular events in patients with stable coronary artery disease (CAD) and&#xD;
      solid evidences demonstrate that PCI of lesions with FFR &gt; 0.80 can be safely deferred&#xD;
      (incidence of MACE &lt; 1% with medical treatment only). Conversely, stenoses with an FFR &lt;0.80&#xD;
      have a poor prognosis and require treatment by PCI 2-4. The afore-mentioned indications come&#xD;
      from studies that mainly involved patients affected by stable CAD, but the role of FFR in the&#xD;
      setting of acute coronary sindrome (ACS) is less clear. Hakeem et al. have recently shown&#xD;
      that deferring percutaneous coronary intervention on the basis of non-ischemic FFR in&#xD;
      patients with an initial presentation of ACS is associated with significantly worse outcomes&#xD;
      than stable patients5.&#xD;
&#xD;
      FFR indeed has the ability to identify vessels with reduced coronary flow, but cannot detect&#xD;
      atherosclerotic plaques with unstable features, which may present without flow limitation&#xD;
      (FFR &gt; 0.80) but can cause acute coronary events 6, 7. Since the prevalence of features of&#xD;
      plaque instability (plaque volume &gt; 70%, minimum luminal area &lt;4 mm2, presence of a &quot;thin cap&#xD;
      fibroatheroma&quot;) increase with the increase of the severity of the stenosis, the decision of&#xD;
      performing PCI for stenoses of clear angiographic severity seems rational and supported by&#xD;
      solid evidence 8. Conversely, delaying PCI of intermediate stenoses on the basis of a&#xD;
      negative FFR can be problematic, particularly in patients with ACS, where the only functional&#xD;
      evaluation with FFR may not be sufficient in the presence of unstable plaques.&#xD;
&#xD;
      Differences in plaque composition between physiologically significant vs non-significant&#xD;
      lesions have never been assessed in either stable and ACS patients.&#xD;
&#xD;
      Intracoronary Near-InfraRed Spectroscopy (NIRS) identifies lipid-rich plaques (LRP) with high&#xD;
      sensibility and specificity. The technique, validated on autopsy specimens, is an effective&#xD;
      tool to detect LRP in vivo, identifying those coronary atheromas that can potentially cause&#xD;
      acute events 9. The NIRS system consists of a 3.2-F rapid exchange catheter (InfraReDx,&#xD;
      Burlington,Massachusetts), a pullback and rotation device, and a console. The measurement of&#xD;
      the probability of LRP for each scanned arterial segment is displayed as a map, with the&#xD;
      x-axis indicating the pullback position in millimeters and the y-axis the circumferential&#xD;
      position of the measurement in degrees. The algorithm displays the probability of lipid&#xD;
      content at the interrogation site by using a false color scale from red (low probability) to&#xD;
      yellow (high probability). The entire display is termed a &quot;chemogram&quot;. Pixels containing&#xD;
      insufficient informations are displayed as black. The ratio between the number of yellow&#xD;
      pixels to the whole number of pixels except the black ones, multiplied by one - thousand, is&#xD;
      the &quot;Lipid Core Burden Index (LCBI)&quot; of the analyzed artery segment. A value of LCBImax &gt; 400&#xD;
      identifies a high lipid content in a given segment. In an autopsy study conducted on human&#xD;
      aortic specimens, the technique reached 90% sensibility and 93 % specificity in the detection&#xD;
      of lipid rich plaques9, opening new horizons in terms of risk stratification and&#xD;
      therapy10-15. To provide a quantitative target suitable for algorithm construction and&#xD;
      validation, a lipid core plaque of interest was defined as a fibroatheroma with a lipid core&#xD;
      &gt; 60° in circumferential extent, &gt;200 µm thick, with a fibrous cap having a mean thickness &lt;&#xD;
      450 µm16.&#xD;
&#xD;
      Aim of the study&#xD;
&#xD;
        -  To compare lipid content expressed by LCBImax value between functionally significant&#xD;
           (FFR &lt; 0.80) and non-significant (FFR &gt; 0.80) stenoses in patients undergoing coronary&#xD;
           angiography because of stable CAD and non-ST elevation acute coronary syndromes.&#xD;
&#xD;
        -  To evaluate the correlation between functional significance (expressed by FFR value) and&#xD;
           lipid content (expressed by LCBImax value) of coronary lesions in patients undergoing&#xD;
           coronary angiography because of stable CAD and non-ST elevation acute coronary&#xD;
           syndromes.&#xD;
&#xD;
      Design of the study This is an observational, prospective, multicentric study: at present&#xD;
      time, two centers (Misericordia Hospital, Grosseto and San Giovanni Hospital, Rome) are going&#xD;
      to take part in the study.&#xD;
&#xD;
      Subjects undergoing coronary angiography for stable CAD and non-ST-segment elevation acute&#xD;
      myocardial infarction (NSTEMI) and unstable angina will be enrolled. Patients included must&#xD;
      have evidence of at least one angiographically borderline stenosis (≥ 40, &lt;70% by&#xD;
      Quantitative Coronary Angiography, QCA) with normal antegrade flow (TIMI 3). The index lesion&#xD;
      will be evaluated by FFR; afterwards, plaque composition and lesion characteristics will be&#xD;
      evaluated by IVUS - NIRS. PCI will be performed according to current guidelines on myocardial&#xD;
      revascularization1.&#xD;
&#xD;
      Patients with hemodynamic instability, ST-segment-elevation myocardial infarction, known&#xD;
      allergy to antiplatelet or anticoagulant drugs, history of previous CABG, significant left&#xD;
      main disease, life expectancy &lt; 1 year, severe renal failure, malignancy, scheduled valve&#xD;
      surgery, inability to provide informed consent, known bronchial asthma, age &lt; 18 will be&#xD;
      excluded.&#xD;
&#xD;
      Endpoints&#xD;
&#xD;
        -  Primary endpoint: percentage of coronary plaques with LCBImax &gt; 400 in lesions with FFR&#xD;
           &gt; 0.80 vs lesions with FFR &lt; 0.80. .&#xD;
&#xD;
        -  Secondary endpoints: 1) lipid content expressed as LCBImax (mean ± SD) in lesions with&#xD;
           FFR &gt; 0.80 vs lesions with FFR &lt; 0.80. 2) Correlation between lipid content (as LCBI&#xD;
           max), and functional significance (as FFR) of the index lesion.&#xD;
&#xD;
      Sample size The sample size will be calculated to demonstrate a decrease in the primary end&#xD;
      point (percentage of coronary plaques with LCBImax &gt; 400) from 36% in FFR positive lesions to&#xD;
      18% in FFR negative lesions, as inferred by previous findings showing a 36% vs 18% prevalence&#xD;
      of thin cap fibroatheroma in lesions with a &gt;70% vs &lt;70% diameter stenosis17. Using&#xD;
      chi-square test for 2 x 2 tables and a 1-sided alpha value of 0.05, a sample of 150 lesions&#xD;
      will provide the study 80% power to meet the primary end point.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date>March 2015</start_date>
  <completion_date type="Anticipated">December 2018</completion_date>
  <primary_completion_date type="Anticipated">December 2018</primary_completion_date>
  <study_type>Observational [Patient Registry]</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <target_duration>1 Year</target_duration>
  <primary_outcome>
    <measure>Percentage of coronary plaques with LCBImax &gt; 400 in lesions with FFR &gt; 0.80 vs lesions with FFR &lt; 0.80.</measure>
    <time_frame>Baseline</time_frame>
  </primary_outcome>
  <number_of_groups>2</number_of_groups>
  <enrollment type="Anticipated">150</enrollment>
  <condition>Borderline Coronary Stenoses Assessment, Fractional Flow Reserve, Plaque Composition</condition>
  <arm_group>
    <arm_group_label>Patients with FFR &gt; 0.80</arm_group_label>
    <description>Group of patients with physiologically non-significant coronary stenoses who will not undergo coronary revascularization</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Patients with FFR &lt; 0.80</arm_group_label>
    <description>Group of patients with physiologically significant coronary stenoses who will undergo coronary revascularization</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>FFR and IVUS-NIRS</intervention_name>
    <arm_group_label>Patients with FFR &lt; 0.80</arm_group_label>
    <arm_group_label>Patients with FFR &gt; 0.80</arm_group_label>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        Subjects undergoing coronary angiography for stable CAD and non-ST-segment elevation acute&#xD;
        myocardial infarction (NSTEMI) and unstable angina will be enrolled. Patients included must&#xD;
        have evidence of at least one angiographically borderline stenosis (≥ 40, &lt;70% by&#xD;
        Quantitative Coronary Angiography, QCA) with normal antegrade flow (TIMI 3). The index&#xD;
        lesion will be evaluated by FFR; afterwards, plaque composition and lesion characteristics&#xD;
        will be evaluated by IVUS - NIRS. PCI will be performed according to current guidelines on&#xD;
        myocardial revascularization1.&#xD;
&#xD;
        Patients with hemodynamic instability, ST-segment-elevation myocardial infarction, known&#xD;
        allergy to antiplatelet or anticoagulant drugs, history of previous CABG, significant left&#xD;
        main disease, life expectancy &lt; 1 year, severe renal failure, malignancy, scheduled valve&#xD;
        surgery, inability to provide informed consent, known bronchial asthma, age &lt; 18 will be&#xD;
        excluded.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Subjects undergoing coronary angiography for stable CAD and non-ST-segment elevation&#xD;
             acute myocardial infarction (NSTEMI) and unstable angina will be enrolled. Patients&#xD;
             included must have evidence of at least one angiographically borderline stenosis (≥&#xD;
             40, &lt;70% by Quantitative Coronary Angiography, QCA) with normal antegrade flow (TIMI&#xD;
             3). The index lesion will be evaluated by FFR; afterwards, plaque composition and&#xD;
             lesion characteristics will be evaluated by IVUS - NIRS. PCI will be performed&#xD;
             according to current guidelines on myocardial revascularization1.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Patients with hemodynamic instability, ST-segment-elevation myocardial infarction,&#xD;
             known allergy to antiplatelet or anticoagulant drugs, history of previous CABG,&#xD;
             significant left main disease, life expectancy &lt; 1 year, severe renal failure,&#xD;
             malignancy, scheduled valve surgery, inability to provide informed consent, known&#xD;
             bronchial asthma.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_contact>
    <last_name>Andrea Picchi</last_name>
    <phone>+390564483465</phone>
    <email>andre.picchi@gmail.com</email>
  </overall_contact>
  <location>
    <facility>
      <name>Cardiology Unit, Misericordia Hospital</name>
      <address>
        <city>Grosseto</city>
        <zip>58100</zip>
        <country>Italy</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Andrea Picchi, Md, PhD</last_name>
      <phone>+390564483465</phone>
      <email>andre.picchi@gmail.com</email>
    </contact>
  </location>
  <location_countries>
    <country>Italy</country>
  </location_countries>
  <verification_date>December 2016</verification_date>
  <study_first_submitted>December 5, 2016</study_first_submitted>
  <study_first_submitted_qc>December 6, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">December 7, 2016</study_first_posted>
  <last_update_submitted>December 9, 2016</last_update_submitted>
  <last_update_submitted_qc>December 9, 2016</last_update_submitted_qc>
  <last_update_posted type="Estimate">December 12, 2016</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>S.M. Misericordia Hospital</investigator_affiliation>
    <investigator_full_name>Andrea Picchi</investigator_full_name>
    <investigator_title>Principal Investigator</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Coronary Stenosis</mesh_term>
    <mesh_term>Constriction, Pathologic</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02985112
org study id: USL9-2015-007-NIRS
nct id: NCT02985112
lead sponsor: 
collaborator: 
Revascularization of borderline coronary stenoses (40-70%) is usually driven by fractional
      flow reserve (FFR) which expresses the physiological significance of a lesion and tells the
      operator whether PCI may reduce the rate of adverse events as compared to medical therapy.
      Coronary stenoses with FFR value < 0.80 are indeed associated with a higher rate of adverse
      event and requires coronary revascularization whereas lesions with FFR > 0.80 show an
      excellent prognosis which cannot be improved by coronary stenting. Such a predictive value of
      FFR is theoretically based only on the degree of myocardial ischemia downstream from a given
      coronary stenosis: however, also plaque composition may play a crucial role in triggering
      future events especially in patients affected by acute coronary syndrome. Differences in
      plaque composition between FFR-positive and FFR negative lesions have never been assessed.
      Intracoronary Near-InfraRed Spectroscopy (NIRS) identifies lipid rich plaques that can
      potentially cause acute events. The aim of this study is to compare the lipid content
      expressed by LCBI (Lipid Core Burden Index) between functionally significant (FFR < 0.80) and
      non-significant (FFR > 0.80) stenoses in patients undergoing coronary angiography because of
      stable CAD and non-ST elevation acute coronary syndromes. This is an observational,
      prospective, multicentric study where we plan to collect 150 coronary lesions.
Background Objective of percutaneous coronary intervention (PCI) is the treatment of
      angiographically significant coronary stenoses in patients affected by stable or unstable
      coronary syndromes 1. When we face an intermediate stenosis (percentage diameter stenosis
      between 40% and 70%), revascularization is guided by the presence of inducible myocardial
      ischemia, detected by non - invasive stress tests or by assessment of fractional flow reserve
      (FFR). FFR is an index of the physiological significance of a coronary stenosis and is
      defined as the ratio of maximal blood flow in a stenotic artery to normal maximal flow. An
      FFR value of 0.80 or less identifies ischemia-causing coronary stenoses with an accuracy of
      more than 90%. FFR is a very accurate tool to identify functionally significant stenoses and
      to predict cardiovascular events in patients with stable coronary artery disease (CAD) and
      solid evidences demonstrate that PCI of lesions with FFR > 0.80 can be safely deferred
      (incidence of MACE < 1% with medical treatment only). Conversely, stenoses with an FFR <0.80
      have a poor prognosis and require treatment by PCI 2-4. The afore-mentioned indications come
      from studies that mainly involved patients affected by stable CAD, but the role of FFR in the
      setting of acute coronary sindrome (ACS) is less clear. Hakeem et al. have recently shown
      that deferring percutaneous coronary intervention on the basis of non-ischemic FFR in
      patients with an initial presentation of ACS is associated with significantly worse outcomes
      than stable patients5.

      FFR indeed has the ability to identify vessels with reduced coronary flow, but cannot detect
      atherosclerotic plaques with unstable features, which may present without flow limitation
      (FFR > 0.80) but can cause acute coronary events 6, 7. Since the prevalence of features of
      plaque instability (plaque volume > 70%, minimum luminal area <4 mm2, presence of a "thin cap
      fibroatheroma") increase with the increase of the severity of the stenosis, the decision of
      performing PCI for stenoses of clear angiographic severity seems rational and supported by
      solid evidence 8. Conversely, delaying PCI of intermediate stenoses on the basis of a
      negative FFR can be problematic, particularly in patients with ACS, where the only functional
      evaluation with FFR may not be sufficient in the presence of unstable plaques.

      Differences in plaque composition between physiologically significant vs non-significant
      lesions have never been assessed in either stable and ACS patients.

      Intracoronary Near-InfraRed Spectroscopy (NIRS) identifies lipid-rich plaques (LRP) with high
      sensibility and specificity. The technique, validated on autopsy specimens, is an effective
      tool to detect LRP in vivo, identifying those coronary atheromas that can potentially cause
      acute events 9. The NIRS system consists of a 3.2-F rapid exchange catheter (InfraReDx,
      Burlington,Massachusetts), a pullback and rotation device, and a console. The measurement of
      the probability of LRP for each scanned arterial segment is displayed as a map, with the
      x-axis indicating the pullback position in millimeters and the y-axis the circumferential
      position of the measurement in degrees. The algorithm displays the probability of lipid
      content at the interrogation site by using a false color scale from red (low probability) to
      yellow (high probability). The entire display is termed a "chemogram". Pixels containing
      insufficient informations are displayed as black. The ratio between the number of yellow
      pixels to the whole number of pixels except the black ones, multiplied by one - thousand, is
      the "Lipid Core Burden Index (LCBI)" of the analyzed artery segment. A value of LCBImax > 400
      identifies a high lipid content in a given segment. In an autopsy study conducted on human
      aortic specimens, the technique reached 90% sensibility and 93 % specificity in the detection
      of lipid rich plaques9, opening new horizons in terms of risk stratification and
      therapy10-15. To provide a quantitative target suitable for algorithm construction and
      validation, a lipid core plaque of interest was defined as a fibroatheroma with a lipid core
      > 60° in circumferential extent, >200 µm thick, with a fibrous cap having a mean thickness <
      450 µm16.

      Aim of the study

        -  To compare lipid content expressed by LCBImax value between functionally significant
           (FFR < 0.80) and non-significant (FFR > 0.80) stenoses in patients undergoing coronary
           angiography because of stable CAD and non-ST elevation acute coronary syndromes.

        -  To evaluate the correlation between functional significance (expressed by FFR value) and
           lipid content (expressed by LCBImax value) of coronary lesions in patients undergoing
           coronary angiography because of stable CAD and non-ST elevation acute coronary
           syndromes.

      Design of the study This is an observational, prospective, multicentric study: at present
      time, two centers (Misericordia Hospital, Grosseto and San Giovanni Hospital, Rome) are going
      to take part in the study.

      Subjects undergoing coronary angiography for stable CAD and non-ST-segment elevation acute
      myocardial infarction (NSTEMI) and unstable angina will be enrolled. Patients included must
      have evidence of at least one angiographically borderline stenosis (≥ 40, <70% by
      Quantitative Coronary Angiography, QCA) with normal antegrade flow (TIMI 3). The index lesion
      will be evaluated by FFR; afterwards, plaque composition and lesion characteristics will be
      evaluated by IVUS - NIRS. PCI will be performed according to current guidelines on myocardial
      revascularization1.

      Patients with hemodynamic instability, ST-segment-elevation myocardial infarction, known
      allergy to antiplatelet or anticoagulant drugs, history of previous CABG, significant left
      main disease, life expectancy < 1 year, severe renal failure, malignancy, scheduled valve
      surgery, inability to provide informed consent, known bronchial asthma, age < 18 will be
      excluded.

      Endpoints

        -  Primary endpoint: percentage of coronary plaques with LCBImax > 400 in lesions with FFR
           > 0.80 vs lesions with FFR < 0.80. .

        -  Secondary endpoints: 1) lipid content expressed as LCBImax (mean ± SD) in lesions with
           FFR > 0.80 vs lesions with FFR < 0.80. 2) Correlation between lipid content (as LCBI
           max), and functional significance (as FFR) of the index lesion.

      Sample size The sample size will be calculated to demonstrate a decrease in the primary end
      point (percentage of coronary plaques with LCBImax > 400) from 36% in FFR positive lesions to
      18% in FFR negative lesions, as inferred by previous findings showing a 36% vs 18% prevalence
      of thin cap fibroatheroma in lesions with a >70% vs <70% diameter stenosis17. Using
      chi-square test for 2 x 2 tables and a 1-sided alpha value of 0.05, a sample of 150 lesions
      will provide the study 80% power to meet the primary end point.
observational model: Cohort
time perspective: Prospective
measure: Percentage of coronary plaques with LCBImax > 400 in lesions with FFR > 0.80 vs lesions with FFR < 0.80.
time frame: Baseline
arm group label: Patients with FFR > 0.80
description: Group of patients with physiologically non-significant coronary stenoses who will not undergo coronary revascularization
arm group label: Patients with FFR < 0.80
description: Group of patients with physiologically significant coronary stenoses who will undergo coronary revascularization
intervention type: Device
intervention name: FFR and IVUS-NIRS
arm group label: Patients with FFR < 0.80
arm group label: Patients with FFR > 0.80
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Andrea Picchi
phone: +390564483465
email: andre.picchi@gmail.com
facility: 
status: Recruiting
contact: 
country: Italy
responsible party type: Principal Investigator
investigator affiliation: S.M. Misericordia Hospital
investigator full name: Andrea Picchi
investigator title: Principal Investigator
mesh term: Coronary Stenosis
mesh term: Constriction, Pathologic