<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03027011</url>
  </required_header>
  <id_info>
    <org_study_id>XYFY-2017-005</org_study_id>
    <nct_id>NCT03027011</nct_id>
  </id_info>
  <brief_title>Remote Ischemic Preconditioning on Brain Injury in Carotid Endarterectomy</brief_title>
  <official_title>Effect of Remote Ischemic Preconditioning on Brain Injury in Carotid Endarterectomy</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>The Affiliated Hospital of Xuzhou Medical University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>The Affiliated Hospital of Xuzhou Medical University</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This is a randomized controlled trial designed to test an intervention (Remote ischemic&#xD;
      preconditioning) in patients undergoing carotid endarterectomy (CEA).Remote ischemic&#xD;
      preconditioning(RIPC) with transient upper limb ischemia/reperfusion is a novel, simple,&#xD;
      cost-free,non-pharmacological and non-invasive strategy.The purpose of this study is to&#xD;
      evaluate the effects of Remote Ischaemic Preconditioning on perioperative ischaemic injury in&#xD;
      patients undergoing carotid endarterectomy compared to control intervention.The outcomes of&#xD;
      interest include neurocognitive function,clinical outcomes,and biomarkers of brain injury.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Remote ischemic preconditioning (RIPC) protocol will be induced during anesthesia by 3 cycles&#xD;
      of 5-min upper limb ischemia and 5-min reperfusion using a blood pressure cuff inflated to a&#xD;
      pressure 200mmHg&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">March 1, 2017</start_date>
  <completion_date type="Anticipated">December 2017</completion_date>
  <primary_completion_date type="Anticipated">December 2017</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Prevention</primary_purpose>
    <masking>Double (Participant, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>S100-beta biomarker</measure>
    <time_frame>48 hours post surgery</time_frame>
    <description>tested by ELISA</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Short - term cognitive function</measure>
    <time_frame>1 day before surgery and 1 week post surgery</time_frame>
    <description>Short - term cognitive function will be tested by mini-mental state examination</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Neuron specific enolase (NSE) biomarker</measure>
    <time_frame>48 hours post surgery</time_frame>
    <description>tested by ELISA</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Sleep quality</measure>
    <time_frame>1 week post surgery</time_frame>
    <description>Sleep quality will be test by medical outcomes study sleep scale</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">40</enrollment>
  <condition>Brain Injuries</condition>
  <condition>Remote Ischemic Preconditioning</condition>
  <arm_group>
    <arm_group_label>Remote Ischemic Preconditioning(RIPC)</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>RIPC will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Control</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Control group without remote ischemic preconditioning</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Remote Ischemic Preconditioning</intervention_name>
    <description>RIPC will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg</description>
    <arm_group_label>Remote Ischemic Preconditioning(RIPC)</arm_group_label>
    <other_name>RIPC</other_name>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Control</intervention_name>
    <description>Control group without remote ischemic preconditioning</description>
    <arm_group_label>Control</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patients undergoing carotid endarterectomy&#xD;
&#xD;
          -  Patients aged 55 years to 80 years&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Inability to give informed consent&#xD;
&#xD;
          -  Known Deep venous thrombosis (DVT) in arm&#xD;
&#xD;
          -  Pre-existing lymphedema or axillary node dissection both arms&#xD;
&#xD;
          -  Arteriovenous fistula or graft in both arms&#xD;
&#xD;
          -  Left ventricular ejection fraction less than 50%&#xD;
&#xD;
          -  Diagnosis of dementia, intellectual disability, or mental illness including&#xD;
             depression, anxiety, or schizophrenia&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>55 Years</minimum_age>
    <maximum_age>80 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Chen Xiuxia, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>The Affiliated Hospital of Xuzhou Medical University</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Chen Xiuxia, MD</last_name>
    <phone>+86-18052268332</phone>
    <email>cxxlxy@sina.com</email>
  </overall_contact>
  <location>
    <facility>
      <name>The Affiliated Hospital of Xuzhou Medical University</name>
      <address>
        <city>Xuzhou</city>
        <state>Jiangsu</state>
        <zip>221000</zip>
        <country>China</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Chen Xiuxia, MD</last_name>
      <phone>+86-18052268332</phone>
      <email>cxxlxy@sina.com</email>
    </contact>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
  <results_reference>
    <citation>Naylor AR. What is the current status of angioplasty vs endarterectomy in patients with asymptomatic carotid artery disease? J Cardiovasc Surg (Torino). 2007 Apr;48(2):161-80.</citation>
    <PMID>17410063</PMID>
  </results_reference>
  <results_reference>
    <citation>Naylor AR. Where next after SPACE and EVA-3S: 'the good, the bad and the ugly!'. Eur J Vasc Endovasc Surg. 2007 Jan;33(1):44-7. doi: 10.1016/j.ejvs.2006.11.002. Epub 2006 Nov 28.</citation>
    <PMID>17126572</PMID>
  </results_reference>
  <results_reference>
    <citation>Brevoord D, Kranke P, Kuijpers M, Weber N, Hollmann M, Preckel B. Remote ischemic conditioning to protect against ischemia-reperfusion injury: a systematic review and meta-analysis. PLoS One. 2012;7(7):e42179. doi: 10.1371/journal.pone.0042179. Epub 2012 Jul 31.</citation>
    <PMID>22860077</PMID>
  </results_reference>
  <results_reference>
    <citation>Sanderson TH, Reynolds CA, Kumar R, Przyklenk K, Huttemann M. Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation. Mol Neurobiol. 2013 Feb;47(1):9-23. doi: 10.1007/s12035-012-8344-z. Epub 2012 Sep 26.</citation>
    <PMID>23011809</PMID>
  </results_reference>
  <results_reference>
    <citation>Pundik S, Xu K, Sundararajan S. Reperfusion brain injury: focus on cellular bioenergetics. Neurology. 2012 Sep 25;79(13 Suppl 1):S44-51. doi: 10.1212/WNL.0b013e3182695a14.</citation>
    <PMID>23008411</PMID>
  </results_reference>
  <results_reference>
    <citation>Bhuiyan MI, Kim YJ. Mechanisms and prospects of ischemic tolerance induced by cerebral preconditioning. Int Neurourol J. 2010 Dec;14(4):203-12. doi: 10.5213/inj.2010.14.4.203. Epub 2010 Dec 31.</citation>
    <PMID>21253330</PMID>
  </results_reference>
  <results_reference>
    <citation>Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 Nov;74(5):1124-36. doi: 10.1161/01.cir.74.5.1124.</citation>
    <PMID>3769170</PMID>
  </results_reference>
  <results_reference>
    <citation>Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993 Mar;87(3):893-9. doi: 10.1161/01.cir.87.3.893.</citation>
    <PMID>7680290</PMID>
  </results_reference>
  <results_reference>
    <citation>Nandagopal K, Dawson TM, Dawson VL. Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance. J Pharmacol Exp Ther. 2001 May;297(2):474-8.</citation>
    <PMID>11303032</PMID>
  </results_reference>
  <results_reference>
    <citation>Kitagawa K, Matsumoto M, Tagaya M, Hata R, Ueda H, Niinobe M, Handa N, Fukunaga R, Kimura K, Mikoshiba K, et al. 'Ischemic tolerance' phenomenon found in the brain. Brain Res. 1990 Sep 24;528(1):21-4. doi: 10.1016/0006-8993(90)90189-i.</citation>
    <PMID>2245337</PMID>
  </results_reference>
  <results_reference>
    <citation>Ederle J, Featherstone RL, Brown MM. Percutaneous transluminal angioplasty and stenting for carotid artery stenosis. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD000515. doi: 10.1002/14651858.CD000515.pub3.</citation>
    <PMID>17943745</PMID>
  </results_reference>
  <results_reference>
    <citation>Lim SY, Yellon DM, Hausenloy DJ. The neural and humoral pathways in remote limb ischemic preconditioning. Basic Res Cardiol. 2010 Sep;105(5):651-5. doi: 10.1007/s00395-010-0099-y. Epub 2010 May 7.</citation>
    <PMID>20449597</PMID>
  </results_reference>
  <results_reference>
    <citation>Manchurov V, Ryazankina N, Khmara T, Skrypnik D, Reztsov R, Vasilieva E, Shpektor A. Remote ischemic preconditioning and endothelial function in patients with acute myocardial infarction and primary PCI. Am J Med. 2014 Jul;127(7):670-3. doi: 10.1016/j.amjmed.2014.02.012. Epub 2014 Feb 21.</citation>
    <PMID>24565591</PMID>
  </results_reference>
  <results_reference>
    <citation>Olguner C, Koca U, Kar A, Karci A, Islekel H, Canyilmaz M, Mavioglu O, Kizildag S, Unlu G, Elar Z. Ischemic preconditioning attenuates the lipid peroxidation and remote lung injury in the rat model of unilateral lower limb ischemia reperfusion. Acta Anaesthesiol Scand. 2006 Feb;50(2):150-5. doi: 10.1111/j.1399-6576.2006.00938.x.</citation>
    <PMID>16430534</PMID>
  </results_reference>
  <results_reference>
    <citation>Xia Z, Herijgers P, Nishida T, Ozaki S, Wouters P, Flameng W. Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep. Can J Anaesth. 2003 May;50(5):481-8. doi: 10.1007/BF03021061. English, French.</citation>
    <PMID>12734158</PMID>
  </results_reference>
  <results_reference>
    <citation>Jiang HW, Chen C, Hao LJ. [Protective effect of limb ischemic preconditioning against liver ischemia/reperfusion injury in the rat]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Nov;26(4):502-4. Chinese.</citation>
    <PMID>21329001</PMID>
  </results_reference>
  <results_reference>
    <citation>Cao L, Yuan G, Wang Y, Chang Y, Xu J, Zou D, Wei L. [Limb ischemic preconditioning reduces rabbit hepatic ischemia-reperfusion injury through inhibition the phosphorylation of proteins in the MAPK signal pathway in the late phase]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Jun;37(6):591-7. doi: 10.3969/j.issn.1672-7347.2012.06.009. Chinese.</citation>
    <PMID>22772420</PMID>
  </results_reference>
  <results_reference>
    <citation>Sun XC, Li WB, Li QJ, Zhang M, Xian XH, Qi J, Jin RL, Li SQ. Limb ischemic preconditioning induces brain ischemic tolerance via p38 MAPK. Brain Res. 2006 Apr 21;1084(1):165-74. doi: 10.1016/j.brainres.2006.02.041. Epub 2006 Apr 21.</citation>
    <PMID>16631139</PMID>
  </results_reference>
  <results_reference>
    <citation>Rehni AK, Shri R, Singh M. Remote ischaemic preconditioning and prevention of cerebral injury. Indian J Exp Biol. 2007 Mar;45(3):247-52.</citation>
    <PMID>17373368</PMID>
  </results_reference>
  <results_reference>
    <citation>Rehni AK, Singh N, Jaggi AS. Possible involvement of insulin, endogenous opioids and calcitonin gene-related peptide in remote ischaemic preconditioning of the brain. Yakugaku Zasshi. 2007 Jun;127(6):1013-20. doi: 10.1248/yakushi.127.1013.</citation>
    <PMID>17541253</PMID>
  </results_reference>
  <results_reference>
    <citation>Vlasov TD, Korzhevskii DE, Poliakova EA. [Ischemic adaptation of the rat brain as a method for protection of endothelium from ischemic reperfusion injury]. Ross Fiziol Zh Im I M Sechenova. 2004 Jan;90(1):40-8. Russian.</citation>
    <PMID>15143491</PMID>
  </results_reference>
  <results_reference>
    <citation>Hahn CD, Manlhiot C, Schmidt MR, Nielsen TT, Redington AN. Remote ischemic per-conditioning: a novel therapy for acute stroke? Stroke. 2011 Oct;42(10):2960-2. doi: 10.1161/STROKEAHA.111.622340. Epub 2011 Aug 11.</citation>
    <PMID>21836089</PMID>
  </results_reference>
  <results_reference>
    <citation>Malhotra S, Naggar I, Stewart M, Rosenbaum DM. Neurogenic pathway mediated remote preconditioning protects the brain from transient focal ischemic injury. Brain Res. 2011 Apr 22;1386:184-90. doi: 10.1016/j.brainres.2011.02.032. Epub 2011 Feb 19.</citation>
    <PMID>21338588</PMID>
  </results_reference>
  <results_reference>
    <citation>Hougaard KD, Hjort N, Zeidler D, Sorensen L, Norgaard A, Hansen TM, von Weitzel-Mudersbach P, Simonsen CZ, Damgaard D, Gottrup H, Svendsen K, Rasmussen PV, Ribe LR, Mikkelsen IK, Nagenthiraja K, Cho TH, Redington AN, Botker HE, Ostergaard L, Mouridsen K, Andersen G. Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial. Stroke. 2014 Jan;45(1):159-67. doi: 10.1161/STROKEAHA.113.001346. Epub 2013 Nov 7.</citation>
    <PMID>24203849</PMID>
  </results_reference>
  <results_reference>
    <citation>Tulu S, Mulino M, Pinggera D, Luger M, Wurtinger P, Grams A, Bodner T, Beer R, Helbok R, Matteucci-Gothe R, Unterhofer C, Gizewski E, Schmutzhard E, Thome C, Ortler M. Remote ischemic preconditioning in the prevention of ischemic brain damage during intracranial aneurysm treatment (RIPAT): study protocol for a randomized controlled trial. Trials. 2015 Dec 29;16:594. doi: 10.1186/s13063-015-1102-6.</citation>
    <PMID>26714784</PMID>
  </results_reference>
  <results_reference>
    <citation>Walsh SR, Nouraei SA, Tang TY, Sadat U, Carpenter RH, Gaunt ME. Remote ischemic preconditioning for cerebral and cardiac protection during carotid endarterectomy: results from a pilot randomized clinical trial. Vasc Endovascular Surg. 2010 Aug;44(6):434-9. doi: 10.1177/1538574410369709. Epub 2010 May 18.</citation>
    <PMID>20484064</PMID>
  </results_reference>
  <verification_date>March 2017</verification_date>
  <study_first_submitted>January 17, 2017</study_first_submitted>
  <study_first_submitted_qc>January 18, 2017</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 20, 2017</study_first_posted>
  <last_update_submitted>March 9, 2017</last_update_submitted>
  <last_update_submitted_qc>March 9, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">March 10, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Brain Injuries</mesh_term>
    <mesh_term>Ischemia</mesh_term>
    <mesh_term>Wounds and Injuries</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
    <ipd_description>IPD will be available when this trial is finished and the article have been published</ipd_description>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03027011
org study id: XYFY-2017-005
nct id: NCT03027011
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
This is a randomized controlled trial designed to test an intervention (Remote ischemic
      preconditioning) in patients undergoing carotid endarterectomy (CEA).Remote ischemic
      preconditioning(RIPC) with transient upper limb ischemia/reperfusion is a novel, simple,
      cost-free,non-pharmacological and non-invasive strategy.The purpose of this study is to
      evaluate the effects of Remote Ischaemic Preconditioning on perioperative ischaemic injury in
      patients undergoing carotid endarterectomy compared to control intervention.The outcomes of
      interest include neurocognitive function,clinical outcomes,and biomarkers of brain injury.
Remote ischemic preconditioning (RIPC) protocol will be induced during anesthesia by 3 cycles
      of 5-min upper limb ischemia and 5-min reperfusion using a blood pressure cuff inflated to a
      pressure 200mmHg
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Prevention
masking: Double (Participant, Outcomes Assessor)
measure: S100-beta biomarker
time frame: 48 hours post surgery
description: tested by ELISA
measure: Short - term cognitive function
time frame: 1 day before surgery and 1 week post surgery
description: Short - term cognitive function will be tested by mini-mental state examination
measure: Neuron specific enolase (NSE) biomarker
time frame: 48 hours post surgery
description: tested by ELISA
measure: Sleep quality
time frame: 1 week post surgery
description: Sleep quality will be test by medical outcomes study sleep scale
arm group label: Remote Ischemic Preconditioning(RIPC)
arm group type: Active Comparator
description: RIPC will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg
arm group label: Control
arm group type: Placebo Comparator
description: Control group without remote ischemic preconditioning
intervention type: Procedure
intervention name: Remote Ischemic Preconditioning
description: RIPC will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg
arm group label: Remote Ischemic Preconditioning(RIPC)
other name: RIPC
intervention type: Procedure
intervention name: Control
description: Control group without remote ischemic preconditioning
arm group label: Control
criteria: 
gender: All
minimum age: 55 Years
maximum age: 80 Years
healthy volunteers: No
last name: Chen Xiuxia, MD
role: Principal Investigator
affiliation: The Affiliated Hospital of Xuzhou Medical University
last name: Chen Xiuxia, MD
phone: +86-18052268332
email: cxxlxy@sina.com
facility: 
status: Recruiting
contact: 
country: China
citation: Naylor AR. What is the current status of angioplasty vs endarterectomy in patients with asymptomatic carotid artery disease? J Cardiovasc Surg (Torino). 2007 Apr;48(2):161-80.
PMID: 17410063
citation: Naylor AR. Where next after SPACE and EVA-3S: 'the good, the bad and the ugly!'. Eur J Vasc Endovasc Surg. 2007 Jan;33(1):44-7. doi: 10.1016/j.ejvs.2006.11.002. Epub 2006 Nov 28.
PMID: 17126572
citation: Brevoord D, Kranke P, Kuijpers M, Weber N, Hollmann M, Preckel B. Remote ischemic conditioning to protect against ischemia-reperfusion injury: a systematic review and meta-analysis. PLoS One. 2012;7(7):e42179. doi: 10.1371/journal.pone.0042179. Epub 2012 Jul 31.
PMID: 22860077
citation: Sanderson TH, Reynolds CA, Kumar R, Przyklenk K, Huttemann M. Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation. Mol Neurobiol. 2013 Feb;47(1):9-23. doi: 10.1007/s12035-012-8344-z. Epub 2012 Sep 26.
PMID: 23011809
citation: Pundik S, Xu K, Sundararajan S. Reperfusion brain injury: focus on cellular bioenergetics. Neurology. 2012 Sep 25;79(13 Suppl 1):S44-51. doi: 10.1212/WNL.0b013e3182695a14.
PMID: 23008411
citation: Bhuiyan MI, Kim YJ. Mechanisms and prospects of ischemic tolerance induced by cerebral preconditioning. Int Neurourol J. 2010 Dec;14(4):203-12. doi: 10.5213/inj.2010.14.4.203. Epub 2010 Dec 31.
PMID: 21253330
citation: Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 Nov;74(5):1124-36. doi: 10.1161/01.cir.74.5.1124.
PMID: 3769170
citation: Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993 Mar;87(3):893-9. doi: 10.1161/01.cir.87.3.893.
PMID: 7680290
citation: Nandagopal K, Dawson TM, Dawson VL. Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance. J Pharmacol Exp Ther. 2001 May;297(2):474-8.
PMID: 11303032
citation: Kitagawa K, Matsumoto M, Tagaya M, Hata R, Ueda H, Niinobe M, Handa N, Fukunaga R, Kimura K, Mikoshiba K, et al. 'Ischemic tolerance' phenomenon found in the brain. Brain Res. 1990 Sep 24;528(1):21-4. doi: 10.1016/0006-8993(90)90189-i.
PMID: 2245337
citation: Ederle J, Featherstone RL, Brown MM. Percutaneous transluminal angioplasty and stenting for carotid artery stenosis. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD000515. doi: 10.1002/14651858.CD000515.pub3.
PMID: 17943745
citation: Lim SY, Yellon DM, Hausenloy DJ. The neural and humoral pathways in remote limb ischemic preconditioning. Basic Res Cardiol. 2010 Sep;105(5):651-5. doi: 10.1007/s00395-010-0099-y. Epub 2010 May 7.
PMID: 20449597
citation: Manchurov V, Ryazankina N, Khmara T, Skrypnik D, Reztsov R, Vasilieva E, Shpektor A. Remote ischemic preconditioning and endothelial function in patients with acute myocardial infarction and primary PCI. Am J Med. 2014 Jul;127(7):670-3. doi: 10.1016/j.amjmed.2014.02.012. Epub 2014 Feb 21.
PMID: 24565591
citation: Olguner C, Koca U, Kar A, Karci A, Islekel H, Canyilmaz M, Mavioglu O, Kizildag S, Unlu G, Elar Z. Ischemic preconditioning attenuates the lipid peroxidation and remote lung injury in the rat model of unilateral lower limb ischemia reperfusion. Acta Anaesthesiol Scand. 2006 Feb;50(2):150-5. doi: 10.1111/j.1399-6576.2006.00938.x.
PMID: 16430534
citation: Xia Z, Herijgers P, Nishida T, Ozaki S, Wouters P, Flameng W. Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep. Can J Anaesth. 2003 May;50(5):481-8. doi: 10.1007/BF03021061. English, French.
PMID: 12734158
citation: Jiang HW, Chen C, Hao LJ. [Protective effect of limb ischemic preconditioning against liver ischemia/reperfusion injury in the rat]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010 Nov;26(4):502-4. Chinese.
PMID: 21329001
citation: Cao L, Yuan G, Wang Y, Chang Y, Xu J, Zou D, Wei L. [Limb ischemic preconditioning reduces rabbit hepatic ischemia-reperfusion injury through inhibition the phosphorylation of proteins in the MAPK signal pathway in the late phase]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Jun;37(6):591-7. doi: 10.3969/j.issn.1672-7347.2012.06.009. Chinese.
PMID: 22772420
citation: Sun XC, Li WB, Li QJ, Zhang M, Xian XH, Qi J, Jin RL, Li SQ. Limb ischemic preconditioning induces brain ischemic tolerance via p38 MAPK. Brain Res. 2006 Apr 21;1084(1):165-74. doi: 10.1016/j.brainres.2006.02.041. Epub 2006 Apr 21.
PMID: 16631139
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responsible party type: Sponsor
mesh term: Brain Injuries
mesh term: Ischemia
mesh term: Wounds and Injuries
sharing ipd: No
ipd description: IPD will be available when this trial is finished and the article have been published