<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03028038</url>
  </required_header>
  <id_info>
    <org_study_id>UDDS-Ortho-04-2016</org_study_id>
    <nct_id>NCT03028038</nct_id>
  </id_info>
  <brief_title>Using Platelet Rich Plasma in Reducing Alveolar Bone Resorption During Rapid Maxillary Expansion</brief_title>
  <official_title>Evaluation of Efficacy of Injectable Platelet-Rich Plasma (PRP) in Reducing Alveolar Bone Resorption Following Rapid Maxillary Expansion (RME): A Cone Beam Computed Tomography (CBCT) Assessment</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Damascus University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Damascus University</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The purpose of this study is to determine if the injection of Platelet-rich plasma (PRP) is&#xD;
      effective in reducing alveolar bone loss that happens after each rapid maxillary expansion&#xD;
      (RME) on the buccal aspect of the posterior teeth.&#xD;
&#xD;
      16 patients with a skeletal maxillary constriction aged between 10-16 years old will get into&#xD;
      orthodontic treatment to widen the maxilla using Hyrax appliance.&#xD;
&#xD;
      An amount of patient blood will be withdrawn and centrifuged to get PRP. Then the PRP will be&#xD;
      injected in one half of each patient mouth in a split-mouth design, beneath the buccal&#xD;
      periosteal of the first molars and first premolars, the halves will be chosen randomly.&#xD;
&#xD;
      High resolution CBCT images will be taken before and after orthodontic treatment to analyze&#xD;
      buccal bone thickness and height changes.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Correction of the maxillary transverse discrepancy is essential for treatment of various&#xD;
      types of malocclusions. Palatal expansion is the most common method used to improve the&#xD;
      transverse dimensions of the maxilla especially Rapid maxillary expansion (RME) . RME is&#xD;
      associated with intermittent high force systems which cause lateral flexion of the alveolar&#xD;
      processes and buccal displacement of the anchorage teeth . Displacement of these teeth&#xD;
      outside the alveolar anatomic limits can damage the periodontium and finally compromising&#xD;
      tooth longevity.&#xD;
&#xD;
      Several researchers have studied the incidence of buccal dehiscence and fenestrations after&#xD;
      RME , using CBCT Images.&#xD;
&#xD;
      From here It was thought about using a method to eliminate these dangerous side effects. It&#xD;
      was found that platelet rich plasma (PRP) has the ability to enhance tissue regeneration,&#xD;
      accelerate wound healing and inducing stem cells differentiation through its growth factors&#xD;
      (GFs).&#xD;
&#xD;
      This is the first study in the world that will use PRP with orthodontic treatment, because of&#xD;
      its benefits and easiness of using in dental clinic.&#xD;
&#xD;
      Study sample, that consists of 16 patients, was calculated using (G-power sample size&#xD;
      calculator) depending on the buccal alveolar bone thickness changes, with a study power of&#xD;
      95%.&#xD;
&#xD;
      Sample will be chosen from the patients who are coming to Orthodontic department in the&#xD;
      Faculty of dentistry - Damascus university.&#xD;
&#xD;
      Allocation of the sides of intervention (PRP injection) and control sides is made by letting&#xD;
      the participants to withdraw a closed envelop from a dark black box. Each envelop in the box&#xD;
      contain either (R letter) for the right side or (L letter) for the left side that will be the&#xD;
      intervention side for that patient.&#xD;
&#xD;
      After ensuring of the patients compliance with the terms and conditions of this study, the&#xD;
      purpose and methods of the study will be explained to the patients using Information Sheet .&#xD;
      In case of approval to participate the patients asked to sign the Informed Consent.&#xD;
&#xD;
      Extra &amp; Intra-oral photographs , impressions and clinical examination will be made.&#xD;
&#xD;
      High resolution CBCT will be taken before the beginning of treatment (T0). Hyrax appliance&#xD;
      will be applied on the first molars and first premolars and cemented using GIC.&#xD;
&#xD;
      After one day of cementation, 20ml of patients' blood will be withdrawn and centrifuged to&#xD;
      get 4 ml of PRP.&#xD;
&#xD;
      The buccal soft tissue will be anesthetized (sub-mucosal) in the intervention side , then the&#xD;
      PRP will be injected at the buccal area of the first molar and first premolar in that side&#xD;
      using insulin syringe , 2 ml for each tooth mentioned in two points. The first point place is&#xD;
      in the middle of the attached gingiva over the mesial root of the first molar and buccal root&#xD;
      of the first premolar. The second point is in the mucosal-gingival junction over the same&#xD;
      root of each tooth.&#xD;
&#xD;
      Starting of expansion will be done in the same day of injection, twice a day until getting an&#xD;
      over correction of 2-3 mm.&#xD;
&#xD;
      After one week, the injection of prp will be repeated in the same way (T1) High resolution&#xD;
      CBCT for the maxilla will be taken 3 months after the beginning of treatment (T2).&#xD;
&#xD;
      All measures will be analyzed before and after treatment between two sides. A questionnaire&#xD;
      will be given to the patients to study pain level accompanying PRP injection compared to the&#xD;
      control side . Pain will be assessed using Visual Analogue Scale (VAS) 1 (No Pain) - 10&#xD;
      (Worst Pain).&#xD;
&#xD;
      A questionnaire will be given to the patients to study their acceptance of new treatment&#xD;
      approach with comprehensive orthodontic treatments.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">July 2016</start_date>
  <completion_date type="Actual">July 15, 2018</completion_date>
  <primary_completion_date type="Actual">May 2017</primary_completion_date>
  <phase>Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Crossover Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Changes in buccal alveolar bone height loss and thickness reduction amount</measure>
    <time_frame>Evaluation before and after RME. (after 3 months)</time_frame>
    <description>Buccal alveolar bone height loss and thickness reduction amount (The incidence of Dehiscence) as a result of RME (On the intervention compared to non-intervention side) before and after expansion. Assessment will be done using CBCT before treatment (T0) and after 3 months (T2)</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Changes in the appliance supporting teeth inclination</measure>
    <time_frame>Evaluation before and after RME. (after 3 months)</time_frame>
    <description>The changes in the appliance supporting teeth inclination before and after 3 months of orthodontic expansion. Assessment will be done using CBCT before treatment (T0) and after 3 months (T2)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain levels</measure>
    <time_frame>3 months</time_frame>
    <description>Pain levels accompanying new treatment approach within orthodontic treatment. A questionnaire will be given to the patients on the first day after PRP first injection and after 3 days , 7 days, after 3 months</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient acceptance</measure>
    <time_frame>3 months</time_frame>
    <description>Patient acceptance of the PRP injection during comprehensive orthodontic treatments.A questionnaire will be given to the patients on the first day after Prp first injection and after 3 days , 7 days, after 3 months</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">16</enrollment>
  <condition>Bone Resorption</condition>
  <arm_group>
    <arm_group_label>Platelet Rich Plasma</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Platelet Rich Plasma (PRP) will be injected beneath the buccal periosteal of the first molar and premolar in one mouth side with a split-mouth design before the beginning of Rapid Maxillary Expansion and after 7 days of it.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>No Platelet Rich Plasma</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>No Platelet Rich Plasma (PRP) will be injected in the other mouth side with a split-mouth design during Rapid Maxillary Expansion.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Platelet Rich Plasma</intervention_name>
    <description>Platelet Rich Plasma (PRP) will be injected beneath the buccal periosteal of the first molar and premolar in one mouth side with a split-mouth design before the beginning of Rapid Maxillary Expansion and after 7 days of it.&#xD;
High resolution cone beam computed tomography (CBCT) will be taken before treatment and after 3 months when the Hyrax is removed.</description>
    <arm_group_label>Platelet Rich Plasma</arm_group_label>
    <other_name>PRP</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>No Platelet Rich Plasma</intervention_name>
    <description>No Platelet Rich Plasma (PRP) will be injected in the other mouth side with a split-mouth design during Rapid Maxillary Expansion.&#xD;
High resolution cone beam computed tomography (CBCT) will be taken before treatment and after 3 months when the Hyrax is removed.</description>
    <arm_group_label>No Platelet Rich Plasma</arm_group_label>
    <other_name>No PRP</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  10-16 years old patients&#xD;
&#xD;
          -  Complete emergence of first molars and first premolars&#xD;
&#xD;
          -  Clinical maxillary transverse deficiency&#xD;
&#xD;
          -  Good oral hygiene (Gingival index &lt;1) according to Silness &amp; loe 1964&#xD;
&#xD;
          -  ( Plaque index &lt;1)&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  The presence of a medical situations that affects orthodontic treatment and&#xD;
             periodontal health&#xD;
&#xD;
          -  The presence of drug therapy affect orthodontic treatment and periodontal health&#xD;
&#xD;
          -  Bad oral hygiene (gingival and plaque index &gt;1)&#xD;
&#xD;
          -  Patient with physical and psychological limitations&#xD;
&#xD;
          -  Metallic restorations or endodontic treatments on the appliance supporting teeth&#xD;
             (first molars and first premolars)&#xD;
&#xD;
          -  Craniofacial anomalies&#xD;
&#xD;
          -  Previous orthodontic treatment&#xD;
&#xD;
          -  Patients who did not correctly follow the protocol of activation&#xD;
&#xD;
          -  Patients who did not return for control dental appointments&#xD;
&#xD;
          -  Patients whose cementation of the appliance failed&#xD;
&#xD;
          -  Patients whose dental structures were difficult to visualize on the CBCT scans as a&#xD;
             result of artifact&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>10 Years</minimum_age>
    <maximum_age>16 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Kinda Sultan, MSc, PhD</last_name>
    <role>Study Chair</role>
    <affiliation>Damascus University</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Damascus University</name>
      <address>
        <city>Damascus</city>
        <country>Syrian Arab Republic</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Syrian Arab Republic</country>
  </location_countries>
  <results_reference>
    <citation>Agarwal A, Gupta ND. Platelet-rich plasma combined with decalcified freeze-dried bone allograft for the treatment of noncontained human intrabony periodontal defects: a randomized controlled split-mouth study. Int J Periodontics Restorative Dent. 2014 Sep-Oct;34(5):705-11. doi: 10.11607/prd.1766.</citation>
    <PMID>25171042</PMID>
  </results_reference>
  <results_reference>
    <citation>Akin M, Baka ZM, Ileri Z, Basciftci FA. Alveolar bone changes after asymmetric rapid maxillary expansion. Angle Orthod. 2015 Sep;85(5):799-805. doi: 10.2319/090214.1. Epub 2014 Dec 5.</citation>
    <PMID>25478739</PMID>
  </results_reference>
  <results_reference>
    <citation>Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing. 2013 Jun 13;10(1):23. doi: 10.1186/1742-4933-10-23.</citation>
    <PMID>23763951</PMID>
  </results_reference>
  <results_reference>
    <citation>Baysal A, Uysal T, Veli I, Ozer T, Karadede I, Hekimoglu S. Evaluation of alveolar bone loss following rapid maxillary expansion using cone-beam computed tomography. Korean J Orthod. 2013 Apr;43(2):83-95. doi: 10.4041/kjod.2013.43.2.83. Epub 2013 Apr 25.</citation>
    <PMID>23671833</PMID>
  </results_reference>
  <results_reference>
    <citation>Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective. J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):189-97. doi: 10.4103/0974-2077.150734.</citation>
    <PMID>25722595</PMID>
  </results_reference>
  <results_reference>
    <citation>DurmuSlar MC, Alpaslan C, Alpaslan G, Cakir M. Clinical and radiographic evaluation of the efficacy of platelet-rich plasma combined with hydroxyapatite bone graft substitutes in the treatment of intra-bony defects in maxillofacial region. Acta Odontol Scand. 2014 Nov;72(8):948-53. doi: 10.3109/00016357.2014.926023. Epub 2014 Jul 9.</citation>
    <PMID>25005628</PMID>
  </results_reference>
  <results_reference>
    <citation>Geramy A, Shahroudi AS. Fixed versus Removable Appliance for Palatal Expansion; A 3D Analysis Using the Finite Element Method. J Dent (Tehran). 2014 Jan;11(1):75-84. Epub 2014 Jan 31.</citation>
    <PMID>24910679</PMID>
  </results_reference>
  <results_reference>
    <citation>Gunyuz Toklu M, Germec-Cakan D, Tozlu M. Periodontal, dentoalveolar, and skeletal effects of tooth-borne and tooth-bone-borne expansion appliances. Am J Orthod Dentofacial Orthop. 2015 Jul;148(1):97-109. doi: 10.1016/j.ajodo.2015.02.022.</citation>
    <PMID>26124033</PMID>
  </results_reference>
  <results_reference>
    <citation>Lin L, Ahn HW, Kim SJ, Moon SC, Kim SH, Nelson G. Tooth-borne vs bone-borne rapid maxillary expanders in late adolescence. Angle Orthod. 2015 Mar;85(2):253-62. doi: 10.2319/030514-156.1. Epub 2014 Dec 9.</citation>
    <PMID>25490552</PMID>
  </results_reference>
  <results_reference>
    <citation>Martinez CE, Gonzalez SA, Palma V, Smith PC. Platelet-Poor and Platelet-Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells. J Periodontol. 2016 Feb;87(2):e18-26. doi: 10.1902/jop.2015.150360. Epub 2015 Sep 14.</citation>
    <PMID>26367495</PMID>
  </results_reference>
  <verification_date>July 2018</verification_date>
  <study_first_submitted>January 18, 2017</study_first_submitted>
  <study_first_submitted_qc>January 18, 2017</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 23, 2017</study_first_posted>
  <last_update_submitted>July 27, 2018</last_update_submitted>
  <last_update_submitted_qc>July 27, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">July 30, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Platelet-rich plasma</keyword>
  <keyword>Rapid maxillary expansion</keyword>
  <keyword>Buccal bone thickness</keyword>
  <keyword>Alveolar bone loss</keyword>
  <keyword>Alveolar bone resorption</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Bone Resorption</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03028038
org study id: UDDS-Ortho-04-2016
nct id: NCT03028038
lead sponsor: 
has dmc: Yes
The purpose of this study is to determine if the injection of Platelet-rich plasma (PRP) is
      effective in reducing alveolar bone loss that happens after each rapid maxillary expansion
      (RME) on the buccal aspect of the posterior teeth.

      16 patients with a skeletal maxillary constriction aged between 10-16 years old will get into
      orthodontic treatment to widen the maxilla using Hyrax appliance.

      An amount of patient blood will be withdrawn and centrifuged to get PRP. Then the PRP will be
      injected in one half of each patient mouth in a split-mouth design, beneath the buccal
      periosteal of the first molars and first premolars, the halves will be chosen randomly.

      High resolution CBCT images will be taken before and after orthodontic treatment to analyze
      buccal bone thickness and height changes.
Correction of the maxillary transverse discrepancy is essential for treatment of various
      types of malocclusions. Palatal expansion is the most common method used to improve the
      transverse dimensions of the maxilla especially Rapid maxillary expansion (RME) . RME is
      associated with intermittent high force systems which cause lateral flexion of the alveolar
      processes and buccal displacement of the anchorage teeth . Displacement of these teeth
      outside the alveolar anatomic limits can damage the periodontium and finally compromising
      tooth longevity.

      Several researchers have studied the incidence of buccal dehiscence and fenestrations after
      RME , using CBCT Images.

      From here It was thought about using a method to eliminate these dangerous side effects. It
      was found that platelet rich plasma (PRP) has the ability to enhance tissue regeneration,
      accelerate wound healing and inducing stem cells differentiation through its growth factors
      (GFs).

      This is the first study in the world that will use PRP with orthodontic treatment, because of
      its benefits and easiness of using in dental clinic.

      Study sample, that consists of 16 patients, was calculated using (G-power sample size
      calculator) depending on the buccal alveolar bone thickness changes, with a study power of
      95%.

      Sample will be chosen from the patients who are coming to Orthodontic department in the
      Faculty of dentistry - Damascus university.

      Allocation of the sides of intervention (PRP injection) and control sides is made by letting
      the participants to withdraw a closed envelop from a dark black box. Each envelop in the box
      contain either (R letter) for the right side or (L letter) for the left side that will be the
      intervention side for that patient.

      After ensuring of the patients compliance with the terms and conditions of this study, the
      purpose and methods of the study will be explained to the patients using Information Sheet .
      In case of approval to participate the patients asked to sign the Informed Consent.

      Extra & Intra-oral photographs , impressions and clinical examination will be made.

      High resolution CBCT will be taken before the beginning of treatment (T0). Hyrax appliance
      will be applied on the first molars and first premolars and cemented using GIC.

      After one day of cementation, 20ml of patients' blood will be withdrawn and centrifuged to
      get 4 ml of PRP.

      The buccal soft tissue will be anesthetized (sub-mucosal) in the intervention side , then the
      PRP will be injected at the buccal area of the first molar and first premolar in that side
      using insulin syringe , 2 ml for each tooth mentioned in two points. The first point place is
      in the middle of the attached gingiva over the mesial root of the first molar and buccal root
      of the first premolar. The second point is in the mucosal-gingival junction over the same
      root of each tooth.

      Starting of expansion will be done in the same day of injection, twice a day until getting an
      over correction of 2-3 mm.

      After one week, the injection of prp will be repeated in the same way (T1) High resolution
      CBCT for the maxilla will be taken 3 months after the beginning of treatment (T2).

      All measures will be analyzed before and after treatment between two sides. A questionnaire
      will be given to the patients to study pain level accompanying PRP injection compared to the
      control side . Pain will be assessed using Visual Analogue Scale (VAS) 1 (No Pain) - 10
      (Worst Pain).

      A questionnaire will be given to the patients to study their acceptance of new treatment
      approach with comprehensive orthodontic treatments.
allocation: Randomized
intervention model: Crossover Assignment
primary purpose: Treatment
masking: Double (Participant, Outcomes Assessor)
measure: Changes in buccal alveolar bone height loss and thickness reduction amount
time frame: Evaluation before and after RME. (after 3 months)
description: Buccal alveolar bone height loss and thickness reduction amount (The incidence of Dehiscence) as a result of RME (On the intervention compared to non-intervention side) before and after expansion. Assessment will be done using CBCT before treatment (T0) and after 3 months (T2)
measure: Changes in the appliance supporting teeth inclination
time frame: Evaluation before and after RME. (after 3 months)
description: The changes in the appliance supporting teeth inclination before and after 3 months of orthodontic expansion. Assessment will be done using CBCT before treatment (T0) and after 3 months (T2)
measure: Pain levels
time frame: 3 months
description: Pain levels accompanying new treatment approach within orthodontic treatment. A questionnaire will be given to the patients on the first day after PRP first injection and after 3 days , 7 days, after 3 months
measure: Patient acceptance
time frame: 3 months
description: Patient acceptance of the PRP injection during comprehensive orthodontic treatments.A questionnaire will be given to the patients on the first day after Prp first injection and after 3 days , 7 days, after 3 months
arm group label: Platelet Rich Plasma
arm group type: Experimental
description: Platelet Rich Plasma (PRP) will be injected beneath the buccal periosteal of the first molar and premolar in one mouth side with a split-mouth design before the beginning of Rapid Maxillary Expansion and after 7 days of it.
arm group label: No Platelet Rich Plasma
arm group type: Experimental
description: No Platelet Rich Plasma (PRP) will be injected in the other mouth side with a split-mouth design during Rapid Maxillary Expansion.
intervention type: Drug
intervention name: Platelet Rich Plasma
description: Platelet Rich Plasma (PRP) will be injected beneath the buccal periosteal of the first molar and premolar in one mouth side with a split-mouth design before the beginning of Rapid Maxillary Expansion and after 7 days of it.
High resolution cone beam computed tomography (CBCT) will be taken before treatment and after 3 months when the Hyrax is removed.
arm group label: Platelet Rich Plasma
other name: PRP
intervention type: Drug
intervention name: No Platelet Rich Plasma
description: No Platelet Rich Plasma (PRP) will be injected in the other mouth side with a split-mouth design during Rapid Maxillary Expansion.
High resolution cone beam computed tomography (CBCT) will be taken before treatment and after 3 months when the Hyrax is removed.
arm group label: No Platelet Rich Plasma
other name: No PRP
criteria: 
gender: All
minimum age: 10 Years
maximum age: 16 Years
healthy volunteers: No
last name: Kinda Sultan, MSc, PhD
role: Study Chair
affiliation: Damascus University
facility: 
country: Syrian Arab Republic
citation: Agarwal A, Gupta ND. Platelet-rich plasma combined with decalcified freeze-dried bone allograft for the treatment of noncontained human intrabony periodontal defects: a randomized controlled split-mouth study. Int J Periodontics Restorative Dent. 2014 Sep-Oct;34(5):705-11. doi: 10.11607/prd.1766.
PMID: 25171042
citation: Akin M, Baka ZM, Ileri Z, Basciftci FA. Alveolar bone changes after asymmetric rapid maxillary expansion. Angle Orthod. 2015 Sep;85(5):799-805. doi: 10.2319/090214.1. Epub 2014 Dec 5.
PMID: 25478739
citation: Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing. 2013 Jun 13;10(1):23. doi: 10.1186/1742-4933-10-23.
PMID: 23763951
citation: Baysal A, Uysal T, Veli I, Ozer T, Karadede I, Hekimoglu S. Evaluation of alveolar bone loss following rapid maxillary expansion using cone-beam computed tomography. Korean J Orthod. 2013 Apr;43(2):83-95. doi: 10.4041/kjod.2013.43.2.83. Epub 2013 Apr 25.
PMID: 23671833
citation: Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective. J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):189-97. doi: 10.4103/0974-2077.150734.
PMID: 25722595
citation: DurmuSlar MC, Alpaslan C, Alpaslan G, Cakir M. Clinical and radiographic evaluation of the efficacy of platelet-rich plasma combined with hydroxyapatite bone graft substitutes in the treatment of intra-bony defects in maxillofacial region. Acta Odontol Scand. 2014 Nov;72(8):948-53. doi: 10.3109/00016357.2014.926023. Epub 2014 Jul 9.
PMID: 25005628
citation: Geramy A, Shahroudi AS. Fixed versus Removable Appliance for Palatal Expansion; A 3D Analysis Using the Finite Element Method. J Dent (Tehran). 2014 Jan;11(1):75-84. Epub 2014 Jan 31.
PMID: 24910679
citation: Gunyuz Toklu M, Germec-Cakan D, Tozlu M. Periodontal, dentoalveolar, and skeletal effects of tooth-borne and tooth-bone-borne expansion appliances. Am J Orthod Dentofacial Orthop. 2015 Jul;148(1):97-109. doi: 10.1016/j.ajodo.2015.02.022.
PMID: 26124033
citation: Lin L, Ahn HW, Kim SJ, Moon SC, Kim SH, Nelson G. Tooth-borne vs bone-borne rapid maxillary expanders in late adolescence. Angle Orthod. 2015 Mar;85(2):253-62. doi: 10.2319/030514-156.1. Epub 2014 Dec 9.
PMID: 25490552
citation: Martinez CE, Gonzalez SA, Palma V, Smith PC. Platelet-Poor and Platelet-Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells. J Periodontol. 2016 Feb;87(2):e18-26. doi: 10.1902/jop.2015.150360. Epub 2015 Sep 14.
PMID: 26367495
responsible party type: Sponsor
mesh term: Bone Resorption
sharing ipd: No