<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03022162</url>
  </required_header>
  <id_info>
    <org_study_id>1758</org_study_id>
    <nct_id>NCT03022162</nct_id>
  </id_info>
  <brief_title>Prevalence of Paclitaxel Induced CIPN-Related Pain and CIPN in Indian Patients With Breast Cancer</brief_title>
  <official_title>Prevalence of Paclitaxel Induced CIPN-Related Pain and CIPN in Indian Patients With Breast Cancer : A Prospective Observational Study</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Tata Memorial Centre</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Tata Memorial Centre</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      Since its introduction in the 1970s, Paclitaxel has been used as an effective anticancer&#xD;
      agent against lung, breast, ovarian, leukopenia and liver cancer. But, Paclitaxel-induced&#xD;
      peripheral neuropathy is the major dose-limiting side effect of paclitaxel.Paclitaxel induced&#xD;
      peripheral neuropathy most commonly presents as&#xD;
&#xD;
        1. Pain&#xD;
&#xD;
        2. Burning,&#xD;
&#xD;
        3. Tingling (&quot;pins and needles&quot; feeling) or electric/shock-like pain,&#xD;
&#xD;
        4. Hyperalgesia,&#xD;
&#xD;
        5. Allodynia,&#xD;
&#xD;
        6. Increased sensitivity to cold or heat These symptoms are classically seen symmetrically&#xD;
           in the distal extremities (glove and stocking distribution).&#xD;
&#xD;
      Most adverse effects associated with chemotherapy are ameliorated after cessation of the&#xD;
      therapy, but CIPN may persist in the longterm, with 30 % patients having CIPN related&#xD;
      symptoms beyond 6 months after completion of chemotherapy7.Understanding the epidemiology of&#xD;
      neuropathic pain in breast cancer patients has high clinical and public health significance.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      PRIMARY AIM / OBJECTIVE:&#xD;
&#xD;
      Our study aims to observe the prevalence of CIPN-related pain in cancer breast patients who&#xD;
      have received Paclitaxel based adjuvant chemotherapy where we define CIPN-related pain as -&#xD;
      &quot;possible&quot; neuropathic pain in patients scoring more than 12 on Leeds Assessment of&#xD;
      Neuropathic Symptoms and Signs pain scale (LANSS).&#xD;
&#xD;
      SECONDARY AIM / OBJECTIVE Since its introduction in the 1970s, Paclitaxel has been used as an&#xD;
      effective anticancer agent against lung, breast, ovarian, leukopenia and liver cancer. But,&#xD;
      Paclitaxel-induced peripheral neuropathy is the major dose-limiting side effect of&#xD;
      paclitaxel.Paclitaxel induced peripheral neuropathy most commonly presents as&#xD;
&#xD;
        1. Pain&#xD;
&#xD;
        2. Burning,&#xD;
&#xD;
        3. Tingling (&quot;pins and needles&quot; feeling) or electric/shock-like pain,&#xD;
&#xD;
        4. Hyperalgesia,&#xD;
&#xD;
        5. Allodynia,&#xD;
&#xD;
        6. Increased sensitivity to cold or heat These symptoms are classically seen symmetrically&#xD;
           in the distal extremities (glove and stocking distribution).&#xD;
&#xD;
      Most adverse effects associated with chemotherapy are ameliorated after cessation of the&#xD;
      therapy, but CIPN may persist in the longterm, with 30 % patients having CIPN related&#xD;
      symptoms beyond 6 months after completion of chemotherapy7.Understanding the epidemiology of&#xD;
      neuropathic pain in breast cancer patients has high clinical and public health significance.&#xD;
&#xD;
      MATERIALS &amp; METHODS:&#xD;
&#xD;
      The cohort will consist of women with early breast cancer (stages I through III) who had&#xD;
      received Paclitaxel chemotherapy for breast cancer as per the Institutional guidelines within&#xD;
      the preceding two years. History suggestive of pre-existing neuropathy will be noted.&#xD;
&#xD;
        1. All patients (who fulfill the inclusion criteria) visiting Tata Memorial hospital during&#xD;
           Feb2017 2016 to June 2017 will be examined in the Medical Oncology OPD by one of the&#xD;
           investigators and the current CIPN and CIPN-related pain score will be documented by&#xD;
           using the NCI-CTCAE and LANSS scale. Then, the patients will be questioned for&#xD;
           thepresence of similar neuropathic symptoms before starting, after starting and during&#xD;
           Paclitaxel the chemotherapy and their replies will be recorded in the.&#xD;
&#xD;
        2. Patients who had received adjuvant chemotherapy with Paclitaxel but who could not&#xD;
           complete their chemotherapy due to Paclitaxel induced adverse effects other than&#xD;
           peripheral neuropathy for eg hypersensitivity to Paclitaxel will be screened but their&#xD;
           data will be excluded from final data assessment.&#xD;
&#xD;
      2. Use of 1. Acetyl-L-carnitine (ALC) 2. Amifostine 3. Amitriptyline 4. CaMg 5.&#xD;
      Diethyldithio-carbamate (DDTC) 6. Glutathione (GSH) 7. Nimodipine 8. All-trans-retinoic acid&#xD;
      9. rhuLIF 10. Vitamin E during Paclitaxel chemotherapy will be noted based on history and&#xD;
      examination of charts.&#xD;
&#xD;
      For CIPN-related pain: The Leeds Assessment of Neuropathic Symptoms and Signs pain scale&#xD;
      (LANSS) is a simple and valid 7-item tool for identifying patients whose pain is dominated by&#xD;
      neuropathic mechanisms. Each item is a binary response (yes or no) to the presence of&#xD;
      symptoms (5 items) or clinical signs (2 items). If score &gt; 12, neuropathic mechanisms are&#xD;
      likely to be contributing to the patient's pain.&#xD;
&#xD;
      NCI-CTCAE : The National Cancer Institute - Common Terminology Criteria for Adverse Events&#xD;
      v4.0, NCI-CTCAE most recently updated in 2010, will be used for grading CIPN. The CTCAE&#xD;
      displays Grades 1 through 5 with unique clinical descriptions of severity for CIPN.&#xD;
      Paclitaxel induced CIPN is defined as NCI-CTCAE Grade 2 or above.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">December 1, 2017</start_date>
  <completion_date type="Actual">May 31, 2018</completion_date>
  <primary_completion_date type="Actual">May 31, 2018</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Prevalence of Paclitaxel induced CIPN-related pain</measure>
    <time_frame>2 years post Paclitaxel Chemotherapy</time_frame>
    <description>CIPN-related pain is defined as - neuropathic pain as a result of chemotherapy induced nerve damage .&#xD;
All patients (who fulfill the inclusion criteria) visiting Tata Memorial Hospital during Feb2017 to Jun2017will be examined in the Medical Oncology OPD by one of the investigators and the current CIPN-related pain score will be documented by using the LANSS scale.&#xD;
LANSS score&gt;12 will be considered as possible CIPN-related pain for statistical analysis</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Prevalence of Paclitaxel induced CIPN</measure>
    <time_frame>2 years post Paclitaxel Chemotherapy</time_frame>
    <description>CIPN defined as - neuropathy symptoms (other than pain) as a result of chemotherapy induced nerve damage .&#xD;
All patients (who fulfill the inclusion criteria) visiting Tata Memorial Hospital during Feb2017 to Jun2017will be examined in the Medical Oncology OPD by one of the investigators and the current CIPN score will be documented by using the NCI-CTCAE v4.0 grading.&#xD;
Paclitaxel induced CIPN is defined as NCI-CTCAE Grade 2 or above for statistical analysis</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>temporal characteristics and risk factors of CIPN-related pain</measure>
    <time_frame>2 years post Paclitaxel Chemotherapy</time_frame>
    <description>The distribution, appearance and disappearance of syptoms related to CIPN will be based on special questionnaire.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Use of Agents offered with an intend to prevent CIPN</measure>
    <time_frame>2 years post Paclitaxel Chemotherapy</time_frame>
    <description>Use of 1. Acetyl-L-carnitine (ALC) 2. Amifostine 3. Amitriptyline 4. CaMg 5. Diethyldithio-carbamate (DDTC) 6. Glutathione (GSH) 7. Nimodipine 8. All-trans-retinoic acid 9. rhuLIF 10. Vitamin E during Paclitaxel chemotherapy will be noted based on history and examination of charts</description>
  </secondary_outcome>
  <enrollment type="Actual">150</enrollment>
  <condition>Breast Cancer Female</condition>
  <condition>Neuropathic Pain</condition>
  <eligibility>
    <study_pop>
      <textblock>
        The cohort will consist of all female patients with primary breast cancer who received&#xD;
        adjuvant Paclitaxel chemotherapy within the preceding 2 year period, visiting TMH from&#xD;
        December 2017 to May 2018.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. Histopathologically confirmed Primary breast cancer&#xD;
&#xD;
          2. Patients who had received adjuvant chemotherapy with Paclitaxel and who have completed&#xD;
             their Paclitaxel chemotherapy within the preceding 2 years i.e. between 1stAugust 2014&#xD;
             to 31st July 2016.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Age below 18 years&#xD;
&#xD;
          2. On current Paclitaxel chemotherapy&#xD;
&#xD;
          3. Patients with radiological evidence of bone metastases.&#xD;
      </textblock>
    </criteria>
    <gender>Female</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Anuja Bidkar, DNBAnes</last_name>
    <role>Study Chair</role>
    <affiliation>Tata Memorial Centre</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Aparna Chatterjee, MDAnes</last_name>
    <role>Study Chair</role>
    <affiliation>Tata Memorial Centre</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Sudeep Gupta, DMOnco</last_name>
    <role>Study Chair</role>
    <affiliation>Tata Memorial Centre</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Parmanand Jain, MDAnes</last_name>
    <role>Principal Investigator</role>
    <affiliation>Tata Memorial Centre</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Anuja Bidkar</name>
      <address>
        <city>Thane</city>
        <state>Maharashtra</state>
        <zip>400614</zip>
        <country>India</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>India</country>
  </location_countries>
  <results_reference>
    <citation>Hough SW, Kanner RM. &quot;Cancer Pain Syndromes&quot; in Principles &amp; Practice of Pain Medicine edited by Warfield, Carol A.; Bajwa, Zahid H. , 2nd Edition (McGraw-Hill, 2004) p 456.</citation>
  </results_reference>
  <results_reference>
    <citation>Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008 Apr 29;70(18):1630-5. doi: 10.1212/01.wnl.0000282763.29778.59. Epub 2007 Nov 14.</citation>
    <PMID>18003941</PMID>
  </results_reference>
  <results_reference>
    <citation>Grond S, Radbruch L, Meuser T, Sabatowski R, Loick G, Lehmann KA. Assessment and treatment of neuropathic cancer pain following WHO guidelines. Pain. 1999 Jan;79(1):15-20. doi: 10.1016/S0304-3959(98)00138-9.</citation>
    <PMID>9928771</PMID>
  </results_reference>
  <results_reference>
    <citation>Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C. Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. Eur J Cancer. 2008 Jul;44(11):1507-15. doi: 10.1016/j.ejca.2008.04.018. Epub 2008 Jun 18.</citation>
    <PMID>18571399</PMID>
  </results_reference>
  <results_reference>
    <citation>Smith BH, Lee J, Price C, Baranowski AP. Neuropathic pain: a pathway for care developed by the British Pain Society. Br J Anaesth. 2013 Jul;111(1):73-9. doi: 10.1093/bja/aet206. Erratum In: Br J Anaesth. 2013 Sep;111(3):522.</citation>
    <PMID>23794648</PMID>
  </results_reference>
  <results_reference>
    <citation>Ventzel L, Jensen AB, Jensen AR, Jensen TS, Finnerup NB. Chemotherapy-induced pain and neuropathy: a prospective study in patients treated with adjuvant oxaliplatin or docetaxel. Pain. 2016 Mar;157(3):560-568. doi: 10.1097/j.pain.0000000000000404.</citation>
    <PMID>26529271</PMID>
  </results_reference>
  <results_reference>
    <citation>Seretny M, Currie GL, Sena ES, Ramnarine S, Grant R, MacLeod MR, Colvin LA, Fallon M. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain. 2014 Dec;155(12):2461-2470. doi: 10.1016/j.pain.2014.09.020. Epub 2014 Sep 23.</citation>
    <PMID>25261162</PMID>
  </results_reference>
  <results_reference>
    <citation>Jensen TS, Baron R, Haanpaa M, Kalso E, Loeser JD, Rice ASC, Treede RD. A new definition of neuropathic pain. Pain. 2011 Oct;152(10):2204-2205. doi: 10.1016/j.pain.2011.06.017. Epub 2011 Jul 18. No abstract available.</citation>
    <PMID>21764514</PMID>
  </results_reference>
  <results_reference>
    <citation>Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DLH, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice ASC, Serra J, Smith BH, Treede RD, Jensen TS. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016 Aug;157(8):1599-1606. doi: 10.1097/j.pain.0000000000000492.</citation>
    <PMID>27115670</PMID>
  </results_reference>
  <verification_date>October 2020</verification_date>
  <study_first_submitted>January 10, 2017</study_first_submitted>
  <study_first_submitted_qc>January 12, 2017</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 16, 2017</study_first_posted>
  <last_update_submitted>October 10, 2020</last_update_submitted>
  <last_update_submitted_qc>October 10, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">October 14, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Tata Memorial Centre</investigator_affiliation>
    <investigator_full_name>parmanand jain</investigator_full_name>
    <investigator_title>Professor, Anaesthesiology, Critical Care &amp; Pain. Head, Division of Pain.</investigator_title>
  </responsible_party>
  <keyword>Neuropathic Pain, Paclitaxel, CIPN</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Breast Neoplasms</mesh_term>
    <mesh_term>Neuralgia</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03022162
org study id: 1758
nct id: NCT03022162
lead sponsor: 
has dmc: Yes
Since its introduction in the 1970s, Paclitaxel has been used as an effective anticancer
      agent against lung, breast, ovarian, leukopenia and liver cancer. But, Paclitaxel-induced
      peripheral neuropathy is the major dose-limiting side effect of paclitaxel.Paclitaxel induced
      peripheral neuropathy most commonly presents as

        1. Pain

        2. Burning,

        3. Tingling ("pins and needles" feeling) or electric/shock-like pain,

        4. Hyperalgesia,

        5. Allodynia,

        6. Increased sensitivity to cold or heat These symptoms are classically seen symmetrically
           in the distal extremities (glove and stocking distribution).

      Most adverse effects associated with chemotherapy are ameliorated after cessation of the
      therapy, but CIPN may persist in the longterm, with 30 % patients having CIPN related
      symptoms beyond 6 months after completion of chemotherapy7.Understanding the epidemiology of
      neuropathic pain in breast cancer patients has high clinical and public health significance.
PRIMARY AIM / OBJECTIVE:

      Our study aims to observe the prevalence of CIPN-related pain in cancer breast patients who
      have received Paclitaxel based adjuvant chemotherapy where we define CIPN-related pain as -
      "possible" neuropathic pain in patients scoring more than 12 on Leeds Assessment of
      Neuropathic Symptoms and Signs pain scale (LANSS).

      SECONDARY AIM / OBJECTIVE Since its introduction in the 1970s, Paclitaxel has been used as an
      effective anticancer agent against lung, breast, ovarian, leukopenia and liver cancer. But,
      Paclitaxel-induced peripheral neuropathy is the major dose-limiting side effect of
      paclitaxel.Paclitaxel induced peripheral neuropathy most commonly presents as

        1. Pain

        2. Burning,

        3. Tingling ("pins and needles" feeling) or electric/shock-like pain,

        4. Hyperalgesia,

        5. Allodynia,

        6. Increased sensitivity to cold or heat These symptoms are classically seen symmetrically
           in the distal extremities (glove and stocking distribution).

      Most adverse effects associated with chemotherapy are ameliorated after cessation of the
      therapy, but CIPN may persist in the longterm, with 30 % patients having CIPN related
      symptoms beyond 6 months after completion of chemotherapy7.Understanding the epidemiology of
      neuropathic pain in breast cancer patients has high clinical and public health significance.

      MATERIALS & METHODS:

      The cohort will consist of women with early breast cancer (stages I through III) who had
      received Paclitaxel chemotherapy for breast cancer as per the Institutional guidelines within
      the preceding two years. History suggestive of pre-existing neuropathy will be noted.

        1. All patients (who fulfill the inclusion criteria) visiting Tata Memorial hospital during
           Feb2017 2016 to June 2017 will be examined in the Medical Oncology OPD by one of the
           investigators and the current CIPN and CIPN-related pain score will be documented by
           using the NCI-CTCAE and LANSS scale. Then, the patients will be questioned for
           thepresence of similar neuropathic symptoms before starting, after starting and during
           Paclitaxel the chemotherapy and their replies will be recorded in the.

        2. Patients who had received adjuvant chemotherapy with Paclitaxel but who could not
           complete their chemotherapy due to Paclitaxel induced adverse effects other than
           peripheral neuropathy for eg hypersensitivity to Paclitaxel will be screened but their
           data will be excluded from final data assessment.

      2. Use of 1. Acetyl-L-carnitine (ALC) 2. Amifostine 3. Amitriptyline 4. CaMg 5.
      Diethyldithio-carbamate (DDTC) 6. Glutathione (GSH) 7. Nimodipine 8. All-trans-retinoic acid
      9. rhuLIF 10. Vitamin E during Paclitaxel chemotherapy will be noted based on history and
      examination of charts.

      For CIPN-related pain: The Leeds Assessment of Neuropathic Symptoms and Signs pain scale
      (LANSS) is a simple and valid 7-item tool for identifying patients whose pain is dominated by
      neuropathic mechanisms. Each item is a binary response (yes or no) to the presence of
      symptoms (5 items) or clinical signs (2 items). If score > 12, neuropathic mechanisms are
      likely to be contributing to the patient's pain.

      NCI-CTCAE : The National Cancer Institute - Common Terminology Criteria for Adverse Events
      v4.0, NCI-CTCAE most recently updated in 2010, will be used for grading CIPN. The CTCAE
      displays Grades 1 through 5 with unique clinical descriptions of severity for CIPN.
      Paclitaxel induced CIPN is defined as NCI-CTCAE Grade 2 or above.
observational model: Cohort
time perspective: Prospective
measure: Prevalence of Paclitaxel induced CIPN-related pain
time frame: 2 years post Paclitaxel Chemotherapy
description: CIPN-related pain is defined as - neuropathic pain as a result of chemotherapy induced nerve damage .
All patients (who fulfill the inclusion criteria) visiting Tata Memorial Hospital during Feb2017 to Jun2017will be examined in the Medical Oncology OPD by one of the investigators and the current CIPN-related pain score will be documented by using the LANSS scale.
LANSS score>12 will be considered as possible CIPN-related pain for statistical analysis
measure: Prevalence of Paclitaxel induced CIPN
time frame: 2 years post Paclitaxel Chemotherapy
description: CIPN defined as - neuropathy symptoms (other than pain) as a result of chemotherapy induced nerve damage .
All patients (who fulfill the inclusion criteria) visiting Tata Memorial Hospital during Feb2017 to Jun2017will be examined in the Medical Oncology OPD by one of the investigators and the current CIPN score will be documented by using the NCI-CTCAE v4.0 grading.
Paclitaxel induced CIPN is defined as NCI-CTCAE Grade 2 or above for statistical analysis
measure: temporal characteristics and risk factors of CIPN-related pain
time frame: 2 years post Paclitaxel Chemotherapy
description: The distribution, appearance and disappearance of syptoms related to CIPN will be based on special questionnaire.
measure: Use of Agents offered with an intend to prevent CIPN
time frame: 2 years post Paclitaxel Chemotherapy
description: Use of 1. Acetyl-L-carnitine (ALC) 2. Amifostine 3. Amitriptyline 4. CaMg 5. Diethyldithio-carbamate (DDTC) 6. Glutathione (GSH) 7. Nimodipine 8. All-trans-retinoic acid 9. rhuLIF 10. Vitamin E during Paclitaxel chemotherapy will be noted based on history and examination of charts
study pop: 
sampling method: Probability Sample
criteria: 
gender: Female
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Anuja Bidkar, DNBAnes
role: Study Chair
affiliation: Tata Memorial Centre
last name: Aparna Chatterjee, MDAnes
role: Study Chair
affiliation: Tata Memorial Centre
last name: Sudeep Gupta, DMOnco
role: Study Chair
affiliation: Tata Memorial Centre
last name: Parmanand Jain, MDAnes
role: Principal Investigator
affiliation: Tata Memorial Centre
facility: 
country: India
citation: Hough SW, Kanner RM. "Cancer Pain Syndromes" in Principles & Practice of Pain Medicine edited by Warfield, Carol A.; Bajwa, Zahid H. , 2nd Edition (McGraw-Hill, 2004) p 456.
citation: Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008 Apr 29;70(18):1630-5. doi: 10.1212/01.wnl.0000282763.29778.59. Epub 2007 Nov 14.
PMID: 18003941
citation: Grond S, Radbruch L, Meuser T, Sabatowski R, Loick G, Lehmann KA. Assessment and treatment of neuropathic cancer pain following WHO guidelines. Pain. 1999 Jan;79(1):15-20. doi: 10.1016/S0304-3959(98)00138-9.
PMID: 9928771
citation: Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C. Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. Eur J Cancer. 2008 Jul;44(11):1507-15. doi: 10.1016/j.ejca.2008.04.018. Epub 2008 Jun 18.
PMID: 18571399
citation: Smith BH, Lee J, Price C, Baranowski AP. Neuropathic pain: a pathway for care developed by the British Pain Society. Br J Anaesth. 2013 Jul;111(1):73-9. doi: 10.1093/bja/aet206. Erratum In: Br J Anaesth. 2013 Sep;111(3):522.
PMID: 23794648
citation: Ventzel L, Jensen AB, Jensen AR, Jensen TS, Finnerup NB. Chemotherapy-induced pain and neuropathy: a prospective study in patients treated with adjuvant oxaliplatin or docetaxel. Pain. 2016 Mar;157(3):560-568. doi: 10.1097/j.pain.0000000000000404.
PMID: 26529271
citation: Seretny M, Currie GL, Sena ES, Ramnarine S, Grant R, MacLeod MR, Colvin LA, Fallon M. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain. 2014 Dec;155(12):2461-2470. doi: 10.1016/j.pain.2014.09.020. Epub 2014 Sep 23.
PMID: 25261162
citation: Jensen TS, Baron R, Haanpaa M, Kalso E, Loeser JD, Rice ASC, Treede RD. A new definition of neuropathic pain. Pain. 2011 Oct;152(10):2204-2205. doi: 10.1016/j.pain.2011.06.017. Epub 2011 Jul 18. No abstract available.
PMID: 21764514
citation: Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DLH, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice ASC, Serra J, Smith BH, Treede RD, Jensen TS. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016 Aug;157(8):1599-1606. doi: 10.1097/j.pain.0000000000000492.
PMID: 27115670
responsible party type: Principal Investigator
investigator affiliation: Tata Memorial Centre
investigator full name: parmanand jain
investigator title: Professor, Anaesthesiology, Critical Care & Pain. Head, Division of Pain.
mesh term: Breast Neoplasms
mesh term: Neuralgia
sharing ipd: No