<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03034343</url>
  </required_header>
  <id_info>
    <org_study_id>PI16/0202</org_study_id>
    <nct_id>NCT03034343</nct_id>
  </id_info>
  <brief_title>Effectiveness of a Brief Psychological Mindfulness Based Intervention for the Treatment of Depression in Primary Care</brief_title>
  <official_title>Effectiveness of a Brief Psychological Mindfulness Based Intervention for the Treatment of Depression in Primary Care: Face-to-face Application, Treatment as Usual and Application Through ICTs</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Universitat Jaume I</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Research Unit in Primary Care of Aragon (Spain)</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Universitat Jaume I</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The aim of this study is to assess and compare a mindfulness low-intensity (4 weeks)&#xD;
      psychological intervention for the treatment of depression in Primary Care between different&#xD;
      groups: a mindfulness intervention applied face to face in group format, a control group that&#xD;
      will receive treatment as usual (TAU) consisting of medical treatment and the same&#xD;
      mindfulness intervention applied by Information and Communication Technologies (ICTs). The&#xD;
      principal hypothesis is that face to face intervention will be more effective than TAU&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The aim of this study is to assess and compare a mindfulness low-intensity (4 weeks)&#xD;
      psychological intervention for the treatment of depression in Primary Care between different&#xD;
      groups: 1) a face-to-face mindfulness intervention in group format (10-12 people/group), 2) a&#xD;
      control group which will received primary care TAU (usual medical treatment) and 3) the same&#xD;
      mindfulness intervention applied by Information and Communication Technologies (ICTs)&#xD;
      (Internet-based program). All participants in the two psychological intervention groups will&#xD;
      also receive usual medical treatment managed by their general practitioner. Each group will&#xD;
      be composed of 40 participants with a total sample of 120. The principal hypothesis is that&#xD;
      face to face intervention will be more effective than TAU. Secondary hypothesis, are: 1) The&#xD;
      online computerized program will be more effective than TAU; 2) The differences between&#xD;
      face-to-face and online format will be analyzed. Finally, a qualitative study will be&#xD;
      conducted in order to analyze the feasibility, acceptance, barriers and causes of drop-outs&#xD;
      and success, expectations, experiences and attitudes that could be obstacles or facilitators&#xD;
      in the interventions, both in patients and in health professionals. This study will allow us&#xD;
      to understand the experiences of depressed patients with these interventions and their&#xD;
      differences.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Active, not recruiting</last_known_status>
  <start_date>October 2016</start_date>
  <completion_date type="Anticipated">June 2020</completion_date>
  <primary_completion_date type="Anticipated">June 2020</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Factorial Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Beck Depression Inventory-II</measure>
    <time_frame>Baseline</time_frame>
  </primary_outcome>
  <primary_outcome>
    <measure>Beck Depression Inventory-II</measure>
    <time_frame>Post-treatment 8 weeks from baseline in 8 weeks intervention group</time_frame>
    <description>In the mindfulness-based intervention applied by ICTs</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Beck Depression Inventory-II</measure>
    <time_frame>post-treatment 4 weeks from baseline in 4 weeks intervention group</time_frame>
    <description>In the mindfulness-based intervention applied face-to-face and TAU group</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Beck Depression Inventory-II</measure>
    <time_frame>Six-months follow-up</time_frame>
  </primary_outcome>
  <primary_outcome>
    <measure>Beck Depression Inventory-II</measure>
    <time_frame>Twelve-months follow-up</time_frame>
  </primary_outcome>
  <secondary_outcome>
    <measure>Sociodemographic data Gender, age, marital status, education, occupation, economical level</measure>
    <time_frame>Baseline</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Health Survey 12 (SF-12)</measure>
    <time_frame>Baseline</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Health Survey 12 (SF-12)</measure>
    <time_frame>Post-treatment 8 weeks from baseline in 8 weeks intervention group</time_frame>
    <description>In the mindfulness-based intervention applied by ICTs</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Health Survey 12 (SF-12)</measure>
    <time_frame>Post-treatment 4 weeks from baseline in 4 weeks intervention group</time_frame>
    <description>In the mindfulness-based intervention applied face-to-face and TAU group</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Health Survey 12 (SF-12)</measure>
    <time_frame>Six-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Health Survey 12 (SF-12)</measure>
    <time_frame>Twelve-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>EuroQol (EQ-5D). Health related quality of life</measure>
    <time_frame>Baseline</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>EuroQol (EQ-5D). Health related quality of life</measure>
    <time_frame>Six-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>EuroQol (EQ-5D). Health related quality of life</measure>
    <time_frame>Twelve-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Positive and negative affect (PANAS)</measure>
    <time_frame>Baseline</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Positive and negative affect (PANAS)</measure>
    <time_frame>Post-treatment 8 weeks from baseline in 8 weeks intervention group</time_frame>
    <description>In the mindfulness-based intervention applied by ICTs</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Positive and negative affect (PANAS)</measure>
    <time_frame>Post-treatment 4 weeks from baseline in 4 weeks intervention group</time_frame>
    <description>In the mindfulness-based intervention applied face-to-face and TAU group</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Positive and negative affect (PANAS)</measure>
    <time_frame>Six-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Positive and negative affect (PANAS)</measure>
    <time_frame>Twelve-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Five Facets and factors of mindfulness (FFMQ)</measure>
    <time_frame>Baseline</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Five Facets and factors of mindfulness (FFMQ)</measure>
    <time_frame>Six-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Five Facets and factors of mindfulness (FFMQ)</measure>
    <time_frame>Twelve-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pemberton Happiness Index (PHI)</measure>
    <time_frame>Baseline</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pemberton Happiness Index (PHI)</measure>
    <time_frame>Six-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pemberton Happiness Index (PHI)</measure>
    <time_frame>Twelve-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient Health Questionnaire-9</measure>
    <time_frame>Baseline</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient Health Questionnaire-9</measure>
    <time_frame>Post-treatment 8 weeks from baseline in 8 weeks intervention group</time_frame>
    <description>In the mindfulness-based intervention applied by ICTs</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient Health Questionnaire-9</measure>
    <time_frame>Post-treatment 4 weeks from baseline in 4 weeks intervention group</time_frame>
    <description>In the mindfulness-based intervention applied face-to-face and TAU group</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient Health Questionnaire-9</measure>
    <time_frame>Six-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Patient Health Questionnaire-9</measure>
    <time_frame>twelve-months follow-up</time_frame>
  </secondary_outcome>
  <other_outcome>
    <measure>Client Service Receipt Inventory (CSRI)</measure>
    <time_frame>Baseline</time_frame>
    <description>This inventory includes the number of times health services have been used.Collect the sick leave, the number of hospital admissions, the number of times that the person attends an emergency service, number of times that is attended by a healthcare professional and finally collects the medication. There is no maximum or minimum score, it simply provides information.</description>
  </other_outcome>
  <other_outcome>
    <measure>Client Service Receipt Inventory (CSRI)</measure>
    <time_frame>Six-months follow-up</time_frame>
    <description>This inventory includes the number of times health services have been used.Collect the sick leave, the number of hospital admissions, the number of times that the person attends an emergency service, number of times that is attended by a healthcare professional and finally collects the medication. There is no maximum or minimum score, it simply provides information.</description>
  </other_outcome>
  <other_outcome>
    <measure>Client Service Receipt Inventory (CSRI)</measure>
    <time_frame>Twelve-months follow-up</time_frame>
    <description>This inventory includes the number of times health services have been used.Collect the sick leave, the number of hospital admissions, the number of times that the person attends an emergency service, number of times that is attended by a healthcare professional and finally collects the medication. There is no maximum or minimum score, it simply provides information.</description>
  </other_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Anticipated">120</enrollment>
  <condition>Depressive Disorder</condition>
  <arm_group>
    <arm_group_label>TAU+mindfulness applied face to face</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>4 sessions of 90 minutes/session Mindfulness based intervention applied in groups of 10-12 people in traditional format. Written material and sound recordings will be offered as support elements. The estimated duration of the face to face program is one month.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>TAU + Mindfulness ICTs intervention</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>4 sessions of 60 minutes/session Mindfulness based intervention applied by ICTs (Internet-based program). The online intervention will be individual and interactive, which will be supported by multimedia material (videos, sound recordings, etc.) and will have internet support. The estimated duration of the online program is two months.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Usual medical treatment (TAU)</arm_group_label>
    <arm_group_type>No Intervention</arm_group_type>
    <description>In this group the general practitioner will apply the usual treatment (medication) but there will be no psychological treatment.</description>
  </arm_group>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Mindfulness</intervention_name>
    <arm_group_label>TAU + Mindfulness ICTs intervention</arm_group_label>
    <arm_group_label>TAU+mindfulness applied face to face</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Be adult&#xD;
&#xD;
          -  Willingness to participate in the study and signing informed consent&#xD;
&#xD;
          -  Ability to understand and write Spanish.&#xD;
&#xD;
          -  DSM-5 diagnose of Major Depression or Dysthymia, mild or moderate depression expressed&#xD;
             as score lower than 14 in the Patient Health Questionnaire (PHQ)&#xD;
&#xD;
          -  Duration of depressive symptoms 2 months or more&#xD;
&#xD;
          -  To have and to handle the computer and internet&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Any diagnose of disease that may affect central nervous system (brain pathology,&#xD;
             traumatic brain injury, dementia, etc.),&#xD;
&#xD;
          -  Other psychiatric diagnoses or acute psychiatric illness (substance dependence or&#xD;
             abuse, history of schizophrenia or other psychotic disorders, eating disorders, etc.),&#xD;
             except for anxious pathology or personality disorders&#xD;
&#xD;
          -  Any medical, infectious or degenerative disease that may affect mood, presence of&#xD;
             delusional ideas or hallucinations consistent or not with mood, and suicide risk&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>70 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>Universitat Jaume I</name>
      <address>
        <city>Castellon de la Plana</city>
        <state>Valencia</state>
        <zip>12071</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Spain</country>
  </location_countries>
  <link>
    <url>http://www.labpsitec.uji.es</url>
    <description>Laboratory of Psychology and Technology of the University Jaume I</description>
  </link>
  <link>
    <url>http://www.webmindfulness.com</url>
    <description>Mental health unit in primary care.</description>
  </link>
  <reference>
    <citation>Andersson G, Titov N. Advantages and limitations of Internet-based interventions for common mental disorders. World Psychiatry. 2014 Feb;13(1):4-11. doi: 10.1002/wps.20083.</citation>
    <PMID>24497236</PMID>
  </reference>
  <reference>
    <citation>Backenstrass M, Joest K, Frank A, Hingmann S, Mundt C, Kronmuller KT. Preferences for treatment in primary care: a comparison of nondepressive, subsyndromal and major depressive patients. Gen Hosp Psychiatry. 2006 Mar-Apr;28(2):178-80. doi: 10.1016/j.genhosppsych.2005.10.001. Erratum In: Gen Hosp Psychiatry. 2006 May-Jun;28(3):266.</citation>
    <PMID>16516070</PMID>
  </reference>
  <reference>
    <citation>Cuijpers P, van Straten A, van Schaik A, Andersson G. Psychological treatment of depression in primary care: a meta-analysis. Br J Gen Pract. 2009 Feb;59(559):e51-60. doi: 10.3399/bjgp09X395139.</citation>
    <PMID>19192368</PMID>
  </reference>
  <reference>
    <citation>Kuyken W, Byford S, Taylor RS, Watkins E, Holden E, White K, Barrett B, Byng R, Evans A, Mullan E, Teasdale JD. Mindfulness-based cognitive therapy to prevent relapse in recurrent depression. J Consult Clin Psychol. 2008 Dec;76(6):966-78. doi: 10.1037/a0013786.</citation>
    <PMID>19045965</PMID>
  </reference>
  <verification_date>March 2020</verification_date>
  <study_first_submitted>January 11, 2017</study_first_submitted>
  <study_first_submitted_qc>January 24, 2017</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 27, 2017</study_first_posted>
  <last_update_submitted>March 30, 2020</last_update_submitted>
  <last_update_submitted_qc>March 30, 2020</last_update_submitted_qc>
  <last_update_posted type="Actual">March 31, 2020</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Mindfulness</keyword>
  <keyword>Internet program</keyword>
  <keyword>Depression</keyword>
  <keyword>Cost-effectiveness</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Depression</mesh_term>
    <mesh_term>Depressive Disorder</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03034343
org study id: PI16/0202
nct id: NCT03034343
lead sponsor: 
collaborator: 
has dmc: No
The aim of this study is to assess and compare a mindfulness low-intensity (4 weeks)
      psychological intervention for the treatment of depression in Primary Care between different
      groups: a mindfulness intervention applied face to face in group format, a control group that
      will receive treatment as usual (TAU) consisting of medical treatment and the same
      mindfulness intervention applied by Information and Communication Technologies (ICTs). The
      principal hypothesis is that face to face intervention will be more effective than TAU
The aim of this study is to assess and compare a mindfulness low-intensity (4 weeks)
      psychological intervention for the treatment of depression in Primary Care between different
      groups: 1) a face-to-face mindfulness intervention in group format (10-12 people/group), 2) a
      control group which will received primary care TAU (usual medical treatment) and 3) the same
      mindfulness intervention applied by Information and Communication Technologies (ICTs)
      (Internet-based program). All participants in the two psychological intervention groups will
      also receive usual medical treatment managed by their general practitioner. Each group will
      be composed of 40 participants with a total sample of 120. The principal hypothesis is that
      face to face intervention will be more effective than TAU. Secondary hypothesis, are: 1) The
      online computerized program will be more effective than TAU; 2) The differences between
      face-to-face and online format will be analyzed. Finally, a qualitative study will be
      conducted in order to analyze the feasibility, acceptance, barriers and causes of drop-outs
      and success, expectations, experiences and attitudes that could be obstacles or facilitators
      in the interventions, both in patients and in health professionals. This study will allow us
      to understand the experiences of depressed patients with these interventions and their
      differences.
allocation: Randomized
intervention model: Factorial Assignment
primary purpose: Treatment
masking: Double (Investigator, Outcomes Assessor)
measure: Beck Depression Inventory-II
time frame: Baseline
measure: Beck Depression Inventory-II
time frame: Post-treatment 8 weeks from baseline in 8 weeks intervention group
description: In the mindfulness-based intervention applied by ICTs
measure: Beck Depression Inventory-II
time frame: post-treatment 4 weeks from baseline in 4 weeks intervention group
description: In the mindfulness-based intervention applied face-to-face and TAU group
measure: Beck Depression Inventory-II
time frame: Six-months follow-up
measure: Beck Depression Inventory-II
time frame: Twelve-months follow-up
measure: Sociodemographic data Gender, age, marital status, education, occupation, economical level
time frame: Baseline
measure: Health Survey 12 (SF-12)
time frame: Baseline
measure: Health Survey 12 (SF-12)
time frame: Post-treatment 8 weeks from baseline in 8 weeks intervention group
description: In the mindfulness-based intervention applied by ICTs
measure: Health Survey 12 (SF-12)
time frame: Post-treatment 4 weeks from baseline in 4 weeks intervention group
description: In the mindfulness-based intervention applied face-to-face and TAU group
measure: Health Survey 12 (SF-12)
time frame: Six-months follow-up
measure: Health Survey 12 (SF-12)
time frame: Twelve-months follow-up
measure: EuroQol (EQ-5D). Health related quality of life
time frame: Baseline
measure: EuroQol (EQ-5D). Health related quality of life
time frame: Six-months follow-up
measure: EuroQol (EQ-5D). Health related quality of life
time frame: Twelve-months follow-up
measure: Positive and negative affect (PANAS)
time frame: Baseline
measure: Positive and negative affect (PANAS)
time frame: Post-treatment 8 weeks from baseline in 8 weeks intervention group
description: In the mindfulness-based intervention applied by ICTs
measure: Positive and negative affect (PANAS)
time frame: Post-treatment 4 weeks from baseline in 4 weeks intervention group
description: In the mindfulness-based intervention applied face-to-face and TAU group
measure: Positive and negative affect (PANAS)
time frame: Six-months follow-up
measure: Positive and negative affect (PANAS)
time frame: Twelve-months follow-up
measure: Five Facets and factors of mindfulness (FFMQ)
time frame: Baseline
measure: Five Facets and factors of mindfulness (FFMQ)
time frame: Six-months follow-up
measure: Five Facets and factors of mindfulness (FFMQ)
time frame: Twelve-months follow-up
measure: Pemberton Happiness Index (PHI)
time frame: Baseline
measure: Pemberton Happiness Index (PHI)
time frame: Six-months follow-up
measure: Pemberton Happiness Index (PHI)
time frame: Twelve-months follow-up
measure: Patient Health Questionnaire-9
time frame: Baseline
measure: Patient Health Questionnaire-9
time frame: Post-treatment 8 weeks from baseline in 8 weeks intervention group
description: In the mindfulness-based intervention applied by ICTs
measure: Patient Health Questionnaire-9
time frame: Post-treatment 4 weeks from baseline in 4 weeks intervention group
description: In the mindfulness-based intervention applied face-to-face and TAU group
measure: Patient Health Questionnaire-9
time frame: Six-months follow-up
measure: Patient Health Questionnaire-9
time frame: twelve-months follow-up
measure: Client Service Receipt Inventory (CSRI)
time frame: Baseline
description: This inventory includes the number of times health services have been used.Collect the sick leave, the number of hospital admissions, the number of times that the person attends an emergency service, number of times that is attended by a healthcare professional and finally collects the medication. There is no maximum or minimum score, it simply provides information.
measure: Client Service Receipt Inventory (CSRI)
time frame: Six-months follow-up
description: This inventory includes the number of times health services have been used.Collect the sick leave, the number of hospital admissions, the number of times that the person attends an emergency service, number of times that is attended by a healthcare professional and finally collects the medication. There is no maximum or minimum score, it simply provides information.
measure: Client Service Receipt Inventory (CSRI)
time frame: Twelve-months follow-up
description: This inventory includes the number of times health services have been used.Collect the sick leave, the number of hospital admissions, the number of times that the person attends an emergency service, number of times that is attended by a healthcare professional and finally collects the medication. There is no maximum or minimum score, it simply provides information.
arm group label: TAU+mindfulness applied face to face
arm group type: Experimental
description: 4 sessions of 90 minutes/session Mindfulness based intervention applied in groups of 10-12 people in traditional format. Written material and sound recordings will be offered as support elements. The estimated duration of the face to face program is one month.
arm group label: TAU + Mindfulness ICTs intervention
arm group type: Experimental
description: 4 sessions of 60 minutes/session Mindfulness based intervention applied by ICTs (Internet-based program). The online intervention will be individual and interactive, which will be supported by multimedia material (videos, sound recordings, etc.) and will have internet support. The estimated duration of the online program is two months.
arm group label: Usual medical treatment (TAU)
arm group type: No Intervention
description: In this group the general practitioner will apply the usual treatment (medication) but there will be no psychological treatment.
intervention type: Behavioral
intervention name: Mindfulness
arm group label: TAU + Mindfulness ICTs intervention
arm group label: TAU+mindfulness applied face to face
criteria: 
gender: All
minimum age: 18 Years
maximum age: 70 Years
healthy volunteers: No
facility: 
country: Spain
url: http://www.labpsitec.uji.es
description: Laboratory of Psychology and Technology of the University Jaume I
url: http://www.webmindfulness.com
description: Mental health unit in primary care.
citation: Andersson G, Titov N. Advantages and limitations of Internet-based interventions for common mental disorders. World Psychiatry. 2014 Feb;13(1):4-11. doi: 10.1002/wps.20083.
PMID: 24497236
citation: Backenstrass M, Joest K, Frank A, Hingmann S, Mundt C, Kronmuller KT. Preferences for treatment in primary care: a comparison of nondepressive, subsyndromal and major depressive patients. Gen Hosp Psychiatry. 2006 Mar-Apr;28(2):178-80. doi: 10.1016/j.genhosppsych.2005.10.001. Erratum In: Gen Hosp Psychiatry. 2006 May-Jun;28(3):266.
PMID: 16516070
citation: Cuijpers P, van Straten A, van Schaik A, Andersson G. Psychological treatment of depression in primary care: a meta-analysis. Br J Gen Pract. 2009 Feb;59(559):e51-60. doi: 10.3399/bjgp09X395139.
PMID: 19192368
citation: Kuyken W, Byford S, Taylor RS, Watkins E, Holden E, White K, Barrett B, Byng R, Evans A, Mullan E, Teasdale JD. Mindfulness-based cognitive therapy to prevent relapse in recurrent depression. J Consult Clin Psychol. 2008 Dec;76(6):966-78. doi: 10.1037/a0013786.
PMID: 19045965
responsible party type: Sponsor
mesh term: Depression
mesh term: Depressive Disorder
sharing ipd: Undecided