<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02973945</url>
  </required_header>
  <id_info>
    <org_study_id>3011</org_study_id>
    <nct_id>NCT02973945</nct_id>
  </id_info>
  <brief_title>High Flow Nasal Cannula and Aerobic Capacity Training</brief_title>
  <official_title>High Flow Nasal Cannula Versus The Venturi Mask During Exercise Training in Chronic Obstructive Pulmonary Disease Patients, a Randomized, Simple Blind, Controlled Trial.</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Hospital Italiano de Buenos Aires</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Hospital Italiano de Buenos Aires</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The aim of this study is to compare exercise capacity in Chronic Obstructive Pulmonary&#xD;
      Disease (COPD) patients before and after an 8 week pulmonary rehabilitation program.&#xD;
&#xD;
      Patients will be randomised in two groups, one arm will received oxygen through High Flow&#xD;
      Nasal Cannula (HFNC) and the other group by The Venturi Mask (VM)&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Design: randomized, single blind, controlled trial.&#xD;
&#xD;
      The main goal of this study is to compare the exercise tolerance in COPD patients after an 8&#xD;
      week pulmonary rehabilitation program using High Flow Nasal Cannula or The Venturi Mask. The&#xD;
      exercise tolerance will be measured in seconds in a Constant Load Treadmill Test (CTLT).&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">July 1, 2017</start_date>
  <completion_date type="Anticipated">May 2019</completion_date>
  <primary_completion_date type="Anticipated">March 2019</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Change in Exercise Capacity - Maximum Walking Time Reached</measure>
    <time_frame>8 weeks</time_frame>
    <description>The exercise capacity test measures the maximum time (in minutes) reached during a Constant Load Treadmill Test (CLTT).&#xD;
The treadmill speed will be constant and set up at 90% of the maximum speed reached in the previous Incremental Load Treadmill Test (ILTT).&#xD;
The patient will walk at the same velocity until he exhausts his capacity thus ending the test.&#xD;
This CLTT will be performed three times, always after an Incremental Load Treadmill Test (ILTT)</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Six Minutes Walking Test</measure>
    <time_frame>8 weeks</time_frame>
    <description>A Six Minute Walking Test will be conducted according to American Thoracic Society (ATS) guide.&#xD;
Patients will be asked to walk as much as they can in that period of time. During the test oxygen saturation and cardiac frequency will be recorded.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Exercise capacity - Maximum Walking Speed Reached</measure>
    <time_frame>8 weeks</time_frame>
    <description>The exercise capacity test measures the maximum speed (in Km/h) reached during an Incremental Load Treadmill Test (ILTT).&#xD;
The test begins at a speed of 3km/h and each minute after will increase by 0.5 km/h.&#xD;
The patient will walk until he exhausts his capacity, once reached, the test will finished.&#xD;
This ILTT will be performed three times, always before the Constant Load Treadmill Test (CLTT)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Quality of Life - The St George's Respiratory Questionnaire</measure>
    <time_frame>8 weeks</time_frame>
    <description>The St George's Respiratory Questionnaire (SGRQ) is an instrument designed to measure impact on overall health, daily life, and perceived well-being in patients with obstructive airways disease.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Quality of Life -Chronic Obstructive Pulmonary Disease Assessment Test</measure>
    <time_frame>8 weeks</time_frame>
    <description>The Chronic Obstructive Pulmonary Disease Assessment Test (CAT) is a patient-completed questionnaire assessing globally the impact of COPD (cough, sputum, dyspnea, chest tightness) on health status.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Dyspnea</measure>
    <time_frame>8 weeks</time_frame>
    <description>The modified Medical research Council Scale (0-4) will be used in order to assess the breathless subjective sensation.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Comfort</measure>
    <time_frame>8 weeks</time_frame>
    <description>Difference in global comfort according to the device used with visual analogue scale (VAS) 0-10 between High Flow Nasal Cannula and The Venturi Mask</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">60</enrollment>
  <condition>COPD</condition>
  <arm_group>
    <arm_group_label>High Flow Nasal Cannula</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>During a 8 week Pulmonary Rehabilitation Program patients will receive oxygen through High Flow Nasal Cannula (HFNC) while they are training aerobic capacity on the treadmill.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>The Venturi Mask</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>During a 8 week Pulmonary Rehabilitation Program patients will receive oxygen through The Venturi Mask (VM) while they are training aerobic capacity on the treadmill.</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>High Flow Nasal Cannula</intervention_name>
    <description>During the pulmonary rehabilitation program, patients will train the aerobic capacity on a treadmill. Patients in the intervention arm will receive oxygen trough High Flow Nasal Cannula (HFNC) at 50 lpm and 40% of oxygen.&#xD;
The aerobic capacity training plan will be conducted three times a week over 24 sessions.</description>
    <arm_group_label>High Flow Nasal Cannula</arm_group_label>
    <other_name>HFNC</other_name>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>The Venturi Mask</intervention_name>
    <description>During the pulmonary rehabilitation program, patients will train the aerobic capacity on a treadmill. Patients in the control arm will receive oxygen trough The Venturi Mask (VM) at 40% of oxygen.&#xD;
The aerobic capacity training plan will be conducted three times a week over 24 sessions.</description>
    <arm_group_label>The Venturi Mask</arm_group_label>
    <other_name>VM</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. Long term oxygen therapy (LTOT) or oxygen needs during exercise.&#xD;
&#xD;
          2. Clinically stable defined as four weeks without exacerbation&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Refusal to participate&#xD;
&#xD;
          2. Any neuromuscular, cardiovascular or any other condition that limits test performance.&#xD;
&#xD;
          3. Contraindication for exercise&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>99 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Nicolas NR Roux, PT-RT</last_name>
    <role>Principal Investigator</role>
    <affiliation>Hospital Italiano de Buenos Aires</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Nicolas NR Roux, PT-RT</last_name>
    <phone>+5411 4959 0200</phone>
    <phone_ext>9814</phone_ext>
    <email>nicolas.roux@hospitalitaliano.org.ar</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Silvina SD Dell'Era, PT-RT</last_name>
    <phone>+5411 4959 0200</phone>
    <phone_ext>9814</phone_ext>
    <email>silvina.dellera@hospitalitaliano.org.ar</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Hospital Italiano de Buenos AIres</name>
      <address>
        <city>Buenos Aires</city>
        <zip>C1181ACH</zip>
        <country>Argentina</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location_countries>
    <country>Argentina</country>
  </location_countries>
  <link>
    <url>http://goldcopd.org/</url>
    <description>Global initiative for Chronic Obstructive Lung Disease. Update 2016</description>
  </link>
  <results_reference>
    <citation>Rabinovich RA, Vilaro J. Structural and functional changes of peripheral muscles in chronic obstructive pulmonary disease patients. Curr Opin Pulm Med. 2010 Mar;16(2):123-33. doi: 10.1097/MCP.0b013e328336438d.</citation>
    <PMID>20071991</PMID>
  </results_reference>
  <results_reference>
    <citation>Maltais F, Decramer M, Casaburi R, Barreiro E, Burelle Y, Debigare R, Dekhuijzen PN, Franssen F, Gayan-Ramirez G, Gea J, Gosker HR, Gosselink R, Hayot M, Hussain SN, Janssens W, Polkey MI, Roca J, Saey D, Schols AM, Spruit MA, Steiner M, Taivassalo T, Troosters T, Vogiatzis I, Wagner PD; ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014 May 1;189(9):e15-62. doi: 10.1164/rccm.201402-0373ST.</citation>
    <PMID>24787074</PMID>
  </results_reference>
  <results_reference>
    <citation>Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, Hill K, Holland AE, Lareau SC, Man WD, Pitta F, Sewell L, Raskin J, Bourbeau J, Crouch R, Franssen FM, Casaburi R, Vercoulen JH, Vogiatzis I, Gosselink R, Clini EM, Effing TW, Maltais F, van der Palen J, Troosters T, Janssen DJ, Collins E, Garcia-Aymerich J, Brooks D, Fahy BF, Puhan MA, Hoogendoorn M, Garrod R, Schols AM, Carlin B, Benzo R, Meek P, Morgan M, Rutten-van Molken MP, Ries AL, Make B, Goldstein RS, Dowson CA, Brozek JL, Donner CF, Wouters EF; ATS/ERS Task Force on Pulmonary Rehabilitation. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64. doi: 10.1164/rccm.201309-1634ST. Erratum In: Am J Respir Crit Care Med. 2014 Jun 15;189(12):1570.</citation>
    <PMID>24127811</PMID>
  </results_reference>
  <results_reference>
    <citation>Guell Rous MR, Diaz Lobato S, Rodriguez Trigo G, Morante Velez F, San Miguel M, Cejudo P, Ortega Ruiz F, Munoz A, Galdiz Iturri JB, Garcia A, Servera E; Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR). Pulmonary rehabilitation. Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR). Arch Bronconeumol. 2014 Aug;50(8):332-44. doi: 10.1016/j.arbres.2014.02.014. Epub 2014 May 17. English, Spanish.</citation>
    <PMID>24845559</PMID>
  </results_reference>
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    <citation>Sivori M, Almeida M, Benzo R, Boim C, Brassesco M, Callejas O, Capparelli I, Conti E, Diaz M, Draghi J, Franco J, Gando S, Giuliano G, Guida R, Jolly E, Pessolano F, Rabinovich R, Ratto P, Rhodius E, Saadia M, Salvado A, Sobrino E, Victorio C. [New argentine consensus of respiratory rehabilitation 2008]. Medicina (B Aires). 2008;68(4):325-44. Spanish.</citation>
    <PMID>18786894</PMID>
  </results_reference>
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    <citation>O'Donnell DE, D'Arsigny C, Webb KA. Effects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001 Mar;163(4):892-8. doi: 10.1164/ajrccm.163.4.2007026.</citation>
    <PMID>11282762</PMID>
  </results_reference>
  <results_reference>
    <citation>Maltais F, Simon M, Jobin J, Desmeules M, Sullivan MJ, Belanger M, Leblanc P. Effects of oxygen on lower limb blood flow and O2 uptake during exercise in COPD. Med Sci Sports Exerc. 2001 Jun;33(6):916-22. doi: 10.1097/00005768-200106000-00010.</citation>
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    <citation>Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Beduneau G, Deletage-Metreau C, Richard JC, Brochard L, Robert R; FLORALI Study Group; REVA Network. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015 Jun 4;372(23):2185-96. doi: 10.1056/NEJMoa1503326. Epub 2015 May 17.</citation>
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    <citation>Nishimura M. High-flow nasal cannula oxygen therapy in adults. J Intensive Care. 2015 Mar 31;3(1):15. doi: 10.1186/s40560-015-0084-5. eCollection 2015.</citation>
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    <citation>Cirio S, Piran M, Vitacca M, Piaggi G, Ceriana P, Prazzoli M, Paneroni M, Carlucci A. Effects of heated and humidified high flow gases during high-intensity constant-load exercise on severe COPD patients with ventilatory limitation. Respir Med. 2016 Sep;118:128-132. doi: 10.1016/j.rmed.2016.08.004. Epub 2016 Aug 8.</citation>
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    <citation>Hardinge M, Suntharalingam J, Wilkinson T; British Thoracic Society. Guideline update: The British Thoracic Society Guidelines on home oxygen use in adults. Thorax. 2015 Jun;70(6):589-91. doi: 10.1136/thoraxjnl-2015-206918. Epub 2015 Apr 27.</citation>
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    <citation>Puente-Maestu L, Palange P, Casaburi R, Laveneziana P, Maltais F, Neder JA, O'Donnell DE, Onorati P, Porszasz J, Rabinovich R, Rossiter HB, Singh S, Troosters T, Ward S. Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement. Eur Respir J. 2016 Feb;47(2):429-60. doi: 10.1183/13993003.00745-2015. Epub 2016 Jan 21.</citation>
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    <citation>ERS Task Force; Palange P, Ward SA, Carlsen KH, Casaburi R, Gallagher CG, Gosselink R, O'Donnell DE, Puente-Maestu L, Schols AM, Singh S, Whipp BJ. Recommendations on the use of exercise testing in clinical practice. Eur Respir J. 2007 Jan;29(1):185-209. doi: 10.1183/09031936.00046906.</citation>
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    <citation>Jones PW, Quirk FH, Baveystock CM. The St George's Respiratory Questionnaire. Respir Med. 1991 Sep;85 Suppl B:25-31; discussion 33-7. doi: 10.1016/s0954-6111(06)80166-6.</citation>
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    <citation>Jones PW, Harding G, Berry P, Wiklund I, Chen WH, Kline Leidy N. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009 Sep;34(3):648-54. doi: 10.1183/09031936.00102509.</citation>
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  </results_reference>
  <verification_date>May 2017</verification_date>
  <study_first_submitted>November 10, 2016</study_first_submitted>
  <study_first_submitted_qc>November 22, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">November 28, 2016</study_first_posted>
  <last_update_submitted>November 16, 2017</last_update_submitted>
  <last_update_submitted_qc>November 16, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">November 20, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Pulmonary Rehabilitation</keyword>
  <keyword>High Flow Nasal Cannula</keyword>
  <keyword>The Venturi Mask</keyword>
  <keyword>Exercise capacity</keyword>
  <keyword>Aerobic capacity</keyword>
  <keyword>HFNC</keyword>
  <patient_data>
    <sharing_ipd>Yes</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02973945
org study id: 3011
nct id: NCT02973945
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
The aim of this study is to compare exercise capacity in Chronic Obstructive Pulmonary
      Disease (COPD) patients before and after an 8 week pulmonary rehabilitation program.

      Patients will be randomised in two groups, one arm will received oxygen through High Flow
      Nasal Cannula (HFNC) and the other group by The Venturi Mask (VM)
Design: randomized, single blind, controlled trial.

      The main goal of this study is to compare the exercise tolerance in COPD patients after an 8
      week pulmonary rehabilitation program using High Flow Nasal Cannula or The Venturi Mask. The
      exercise tolerance will be measured in seconds in a Constant Load Treadmill Test (CTLT).
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Single (Outcomes Assessor)
measure: Change in Exercise Capacity - Maximum Walking Time Reached
time frame: 8 weeks
description: The exercise capacity test measures the maximum time (in minutes) reached during a Constant Load Treadmill Test (CLTT).
The treadmill speed will be constant and set up at 90% of the maximum speed reached in the previous Incremental Load Treadmill Test (ILTT).
The patient will walk at the same velocity until he exhausts his capacity thus ending the test.
This CLTT will be performed three times, always after an Incremental Load Treadmill Test (ILTT)
measure: Six Minutes Walking Test
time frame: 8 weeks
description: A Six Minute Walking Test will be conducted according to American Thoracic Society (ATS) guide.
Patients will be asked to walk as much as they can in that period of time. During the test oxygen saturation and cardiac frequency will be recorded.
measure: Exercise capacity - Maximum Walking Speed Reached
time frame: 8 weeks
description: The exercise capacity test measures the maximum speed (in Km/h) reached during an Incremental Load Treadmill Test (ILTT).
The test begins at a speed of 3km/h and each minute after will increase by 0.5 km/h.
The patient will walk until he exhausts his capacity, once reached, the test will finished.
This ILTT will be performed three times, always before the Constant Load Treadmill Test (CLTT)
measure: Quality of Life - The St George's Respiratory Questionnaire
time frame: 8 weeks
description: The St George's Respiratory Questionnaire (SGRQ) is an instrument designed to measure impact on overall health, daily life, and perceived well-being in patients with obstructive airways disease.
measure: Quality of Life -Chronic Obstructive Pulmonary Disease Assessment Test
time frame: 8 weeks
description: The Chronic Obstructive Pulmonary Disease Assessment Test (CAT) is a patient-completed questionnaire assessing globally the impact of COPD (cough, sputum, dyspnea, chest tightness) on health status.
measure: Dyspnea
time frame: 8 weeks
description: The modified Medical research Council Scale (0-4) will be used in order to assess the breathless subjective sensation.
measure: Comfort
time frame: 8 weeks
description: Difference in global comfort according to the device used with visual analogue scale (VAS) 0-10 between High Flow Nasal Cannula and The Venturi Mask
arm group label: High Flow Nasal Cannula
arm group type: Experimental
description: During a 8 week Pulmonary Rehabilitation Program patients will receive oxygen through High Flow Nasal Cannula (HFNC) while they are training aerobic capacity on the treadmill.
arm group label: The Venturi Mask
arm group type: Active Comparator
description: During a 8 week Pulmonary Rehabilitation Program patients will receive oxygen through The Venturi Mask (VM) while they are training aerobic capacity on the treadmill.
intervention type: Device
intervention name: High Flow Nasal Cannula
description: During the pulmonary rehabilitation program, patients will train the aerobic capacity on a treadmill. Patients in the intervention arm will receive oxygen trough High Flow Nasal Cannula (HFNC) at 50 lpm and 40% of oxygen.
The aerobic capacity training plan will be conducted three times a week over 24 sessions.
arm group label: High Flow Nasal Cannula
other name: HFNC
intervention type: Device
intervention name: The Venturi Mask
description: During the pulmonary rehabilitation program, patients will train the aerobic capacity on a treadmill. Patients in the control arm will receive oxygen trough The Venturi Mask (VM) at 40% of oxygen.
The aerobic capacity training plan will be conducted three times a week over 24 sessions.
arm group label: The Venturi Mask
other name: VM
criteria: 
gender: All
minimum age: 18 Years
maximum age: 99 Years
healthy volunteers: No
last name: Nicolas NR Roux, PT-RT
role: Principal Investigator
affiliation: Hospital Italiano de Buenos Aires
last name: Nicolas NR Roux, PT-RT
phone: +5411 4959 0200
phone ext: 9814
email: nicolas.roux@hospitalitaliano.org.ar
last name: Silvina SD Dell'Era, PT-RT
phone: +5411 4959 0200
phone ext: 9814
email: silvina.dellera@hospitalitaliano.org.ar
facility: 
status: Recruiting
country: Argentina
url: http://goldcopd.org/
description: Global initiative for Chronic Obstructive Lung Disease. Update 2016
citation: Rabinovich RA, Vilaro J. Structural and functional changes of peripheral muscles in chronic obstructive pulmonary disease patients. Curr Opin Pulm Med. 2010 Mar;16(2):123-33. doi: 10.1097/MCP.0b013e328336438d.
PMID: 20071991
citation: Maltais F, Decramer M, Casaburi R, Barreiro E, Burelle Y, Debigare R, Dekhuijzen PN, Franssen F, Gayan-Ramirez G, Gea J, Gosker HR, Gosselink R, Hayot M, Hussain SN, Janssens W, Polkey MI, Roca J, Saey D, Schols AM, Spruit MA, Steiner M, Taivassalo T, Troosters T, Vogiatzis I, Wagner PD; ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014 May 1;189(9):e15-62. doi: 10.1164/rccm.201402-0373ST.
PMID: 24787074
citation: Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, Hill K, Holland AE, Lareau SC, Man WD, Pitta F, Sewell L, Raskin J, Bourbeau J, Crouch R, Franssen FM, Casaburi R, Vercoulen JH, Vogiatzis I, Gosselink R, Clini EM, Effing TW, Maltais F, van der Palen J, Troosters T, Janssen DJ, Collins E, Garcia-Aymerich J, Brooks D, Fahy BF, Puhan MA, Hoogendoorn M, Garrod R, Schols AM, Carlin B, Benzo R, Meek P, Morgan M, Rutten-van Molken MP, Ries AL, Make B, Goldstein RS, Dowson CA, Brozek JL, Donner CF, Wouters EF; ATS/ERS Task Force on Pulmonary Rehabilitation. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64. doi: 10.1164/rccm.201309-1634ST. Erratum In: Am J Respir Crit Care Med. 2014 Jun 15;189(12):1570.
PMID: 24127811
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