<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03016182</url>
  </required_header>
  <id_info>
    <org_study_id>XYFY-2017-004</org_study_id>
    <nct_id>NCT03016182</nct_id>
  </id_info>
  <brief_title>Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery</brief_title>
  <official_title>Effect of Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Xuzhou Medical University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Xuzhou Medical University</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      During cardiac surgery with cardiopulmonary bypass , pulmonary dysfunction remains to be a&#xD;
      problem complicating the postoperative course of the patients.Remote ischemic&#xD;
      preconditioning(RIPC) with transient upper limb ischemia/reperfusion is a novel, simple,&#xD;
      cost-free,non-pharmacological and non-invasive strategy.Recent several trials suggested that&#xD;
      RIPC could provide pulmonary protection by reducing serum biomarkers,however,whether the RIPC&#xD;
      can improve the clinical outcomes in patients undergoing on-pump cardiac surgery,is still&#xD;
      uncertain.&#xD;
&#xD;
      The study hypothesis is: remote ischemic preconditioning will provide lung-protective effect&#xD;
      and improve clinical outcomes in patients undergoing cardic surgery.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Remote ischemic preconditioning (RIPC) protocol will be induced during anesthesia by 3 cycles&#xD;
      of 5-min upper limb ischemia and 5-min reperfusion using a blood pressure cuff inflated to a&#xD;
      pressure 200mmHg&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date type="Actual">February 7, 2017</start_date>
  <completion_date type="Anticipated">February 2018</completion_date>
  <primary_completion_date type="Anticipated">February 2018</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Prevention</primary_purpose>
    <masking>Double (Participant, Investigator)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Comparison of PaO2/FiO2 over 24 hours after cardiac surgery</measure>
    <time_frame>24 hours post surgery</time_frame>
  </primary_outcome>
  <secondary_outcome>
    <measure>All-cause mortality</measure>
    <time_frame>30 days post surgery</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Postoperative Pulmonary Complications</measure>
    <time_frame>30 days post surgery</time_frame>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">60</enrollment>
  <condition>Lung Injury</condition>
  <condition>Remote Ischemic Preconditioning</condition>
  <arm_group>
    <arm_group_label>Remote Ischemic Preconditioning(RIPC)</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg will be given to RIPC</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Control</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Control group without remote ischemic preconditioning</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Remote Ischemic Preconditioning</intervention_name>
    <description>RIPC will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg</description>
    <arm_group_label>Remote Ischemic Preconditioning(RIPC)</arm_group_label>
    <other_name>RIPC</other_name>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Control</intervention_name>
    <description>Control group witnout remote ischemic preconditioning</description>
    <arm_group_label>Control</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. Patients undergoing heart surgery on cardiopulmonary bypass&#xD;
&#xD;
          2. Patients aged 18 years to 80 years&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Inability to give informed consent&#xD;
&#xD;
          2. Preoperative severe impairment of respiratory function (arterial oxygen tension (PaO2)&#xD;
             &lt;60 mmHg or FEV1&lt;50% predicted)&#xD;
&#xD;
          3. Prior receipt of chemotherapy or radiation therapy or immunotherapy&#xD;
&#xD;
          4. left ventricular ejection fraction less than 30%&#xD;
&#xD;
          5. preoperative use of inotropics or mechanical assist device&#xD;
&#xD;
          6. Patients with significant hepatic dysfunction (Prothrombin&gt;2.0 ratio)&#xD;
&#xD;
          7. Patients with known renal failure with a GFR&lt;30 mL/min/1.73 m2&#xD;
&#xD;
          8. recent myocardial infarction (within 7 days)&#xD;
&#xD;
          9. Systemic or local active infections (either clinically defined or suggested by&#xD;
             evidence such as elevated C-reactive protein levels, leukocytosis, or a body&#xD;
             temperature&gt;38℃)&#xD;
&#xD;
         10. Significant peripheral arterial disease affecting the upper limbs&#xD;
&#xD;
         11. surgeries: cardiac transplantation, concomitant carotid endarterectomy , previous&#xD;
             heart surgery,, off-pump surgery, emergency surgery&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>80 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Liu Su, M.D/Ph.D</last_name>
    <role>Principal Investigator</role>
    <affiliation>The Affiliated Hospital of Xuzhou Medical University</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Liu Su, M.D/Ph.D</last_name>
    <phone>+86-18118309692</phone>
    <email>xyfymzk@163.com</email>
  </overall_contact>
  <location>
    <facility>
      <name>The Affiliated Hospital of Xuzhou Medical University</name>
      <address>
        <city>Xuzhou</city>
        <state>Jiangsu</state>
        <country>China</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
  <results_reference>
    <citation>Domanski MJ, Mahaffey K, Hasselblad V, Brener SJ, Smith PK, Hillis G, Engoren M, Alexander JH, Levy JH, Chaitman BR, Broderick S, Mack MJ, Pieper KS, Farkouh ME. Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery. JAMA. 2011 Feb 9;305(6):585-91. doi: 10.1001/jama.2011.99.</citation>
    <PMID>21304084</PMID>
  </results_reference>
  <results_reference>
    <citation>JENNINGS RB, SOMMERS HM, SMYTH GA, FLACK HA, LINN H. Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. Arch Pathol. 1960 Jul;70:68-78. No abstract available.</citation>
    <PMID>14407094</PMID>
  </results_reference>
  <results_reference>
    <citation>Braunwald E, Kloner RA. Myocardial reperfusion: a double-edged sword? J Clin Invest. 1985 Nov;76(5):1713-9. doi: 10.1172/JCI112160. No abstract available.</citation>
    <PMID>4056048</PMID>
  </results_reference>
  <results_reference>
    <citation>Sullivan PJ, Sweeney KJ, Hirpara KM, Malone CB, Curtin W, Kerin MJ. Cyclical ischaemic preconditioning modulates the adaptive immune response in human limb ischaemia-reperfusion injury. Br J Surg. 2009 Apr;96(4):381-90. doi: 10.1002/bjs.6554.</citation>
    <PMID>19283744</PMID>
  </results_reference>
  <results_reference>
    <citation>Bolli R. The late phase of preconditioning. Circ Res. 2000 Nov 24;87(11):972-83. doi: 10.1161/01.res.87.11.972.</citation>
    <PMID>11090541</PMID>
  </results_reference>
  <results_reference>
    <citation>Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 Nov;74(5):1124-36. doi: 10.1161/01.cir.74.5.1124.</citation>
    <PMID>3769170</PMID>
  </results_reference>
  <results_reference>
    <citation>Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993 Mar;87(3):893-9. doi: 10.1161/01.cir.87.3.893.</citation>
    <PMID>7680290</PMID>
  </results_reference>
  <results_reference>
    <citation>Gho BC, Schoemaker RG, van den Doel MA, Duncker DJ, Verdouw PD. Myocardial protection by brief ischemia in noncardiac tissue. Circulation. 1996 Nov 1;94(9):2193-200. doi: 10.1161/01.cir.94.9.2193.</citation>
    <PMID>8901671</PMID>
  </results_reference>
  <results_reference>
    <citation>Oxman T, Arad M, Klein R, Avazov N, Rabinowitz B. Limb ischemia preconditions the heart against reperfusion tachyarrhythmia. Am J Physiol. 1997 Oct;273(4):H1707-12. doi: 10.1152/ajpheart.1997.273.4.H1707.</citation>
    <PMID>9362234</PMID>
  </results_reference>
  <results_reference>
    <citation>Li G, Labruto F, Sirsjo A, Chen F, Vaage J, Valen G. Myocardial protection by remote preconditioning: the role of nuclear factor kappa-B p105 and inducible nitric oxide synthase. Eur J Cardiothorac Surg. 2004 Nov;26(5):968-73. doi: 10.1016/j.ejcts.2004.06.015.</citation>
    <PMID>15519191</PMID>
  </results_reference>
  <results_reference>
    <citation>Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, Vogel M, Sorensen K, Redington AN, MacAllister R. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation. 2002 Dec 3;106(23):2881-3. doi: 10.1161/01.cir.0000043806.51912.9b.</citation>
    <PMID>12460865</PMID>
  </results_reference>
  <results_reference>
    <citation>Hausenloy DJ, Yellon DM. Remote ischaemic preconditioning: underlying mechanisms and clinical application. Cardiovasc Res. 2008 Aug 1;79(3):377-86. doi: 10.1093/cvr/cvn114. Epub 2008 May 2.</citation>
    <PMID>18456674</PMID>
  </results_reference>
  <results_reference>
    <citation>Sivaraman V, Pickard JM, Hausenloy DJ. Remote ischaemic conditioning: cardiac protection from afar. Anaesthesia. 2015 Jun;70(6):732-48. doi: 10.1111/anae.12973. Epub 2015 Feb 26.</citation>
    <PMID>25961420</PMID>
  </results_reference>
  <results_reference>
    <citation>Heusch G, Botker HE, Przyklenk K, Redington A, Yellon D. Remote ischemic conditioning. J Am Coll Cardiol. 2015 Jan 20;65(2):177-95. doi: 10.1016/j.jacc.2014.10.031.</citation>
    <PMID>25593060</PMID>
  </results_reference>
  <results_reference>
    <citation>Kerendi F, Kin H, Halkos ME, Jiang R, Zatta AJ, Zhao ZQ, Guyton RA, Vinten-Johansen J. Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors. Basic Res Cardiol. 2005 Sep;100(5):404-12. doi: 10.1007/s00395-005-0539-2. Epub 2005 Jun 17.</citation>
    <PMID>15965583</PMID>
  </results_reference>
  <results_reference>
    <citation>Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet. 2007 Aug 18;370(9587):575-9. doi: 10.1016/S0140-6736(07)61296-3.</citation>
    <PMID>17707752</PMID>
  </results_reference>
  <results_reference>
    <citation>Hammermeister KE, Burchfiel C, Johnson R, Grover FL. Identification of patients at greatest risk for developing major complications at cardiac surgery. Circulation. 1990 Nov;82(5 Suppl):IV380-9. Erratum In: Circulation 1991 Jul;84(1):446.</citation>
    <PMID>2225429</PMID>
  </results_reference>
  <results_reference>
    <citation>Messent M, Sullivan K, Keogh BF, Morgan CJ, Evans TW. Adult respiratory distress syndrome following cardiopulmonary bypass: incidence and prediction. Anaesthesia. 1992 Mar;47(3):267-8. doi: 10.1111/j.1365-2044.1992.tb02134.x.</citation>
    <PMID>1566999</PMID>
  </results_reference>
  <results_reference>
    <citation>Wan S, LeClerc JL, Vincent JL. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest. 1997 Sep;112(3):676-92. doi: 10.1378/chest.112.3.676.</citation>
    <PMID>9315800</PMID>
  </results_reference>
  <results_reference>
    <citation>Kharbanda RK, Li J, Konstantinov IE, Cheung MM, White PA, Frndova H, Stokoe J, Cox P, Vogel M, Van Arsdell G, MacAllister R, Redington AN. Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study. Heart. 2006 Oct;92(10):1506-11. doi: 10.1136/hrt.2004.042366. Epub 2006 Jul 3.</citation>
    <PMID>16818489</PMID>
  </results_reference>
  <results_reference>
    <citation>Xia Z, Herijgers P, Nishida T, Ozaki S, Wouters P, Flameng W. Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep. Can J Anaesth. 2003 May;50(5):481-8. doi: 10.1007/BF03021061. English, French.</citation>
    <PMID>12734158</PMID>
  </results_reference>
  <results_reference>
    <citation>Cheung MM, Kharbanda RK, Konstantinov IE, Shimizu M, Frndova H, Li J, Holtby HM, Cox PN, Smallhorn JF, Van Arsdell GS, Redington AN. Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol. 2006 Jun 6;47(11):2277-82. doi: 10.1016/j.jacc.2006.01.066. Epub 2006 May 15.</citation>
    <PMID>16750696</PMID>
  </results_reference>
  <results_reference>
    <citation>Zhou W, Zeng D, Chen R, Liu J, Yang G, Liu P, Zhou X. Limb ischemic preconditioning reduces heart and lung injury after an open heart operation in infants. Pediatr Cardiol. 2010 Jan;31(1):22-9. doi: 10.1007/s00246-009-9536-9. Epub 2009 Sep 29.</citation>
    <PMID>19787388</PMID>
  </results_reference>
  <results_reference>
    <citation>Kim JC, Shim JK, Lee S, Yoo YC, Yang SY, Kwak YL. Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery. Chest. 2012 Aug;142(2):467-475. doi: 10.1378/chest.11-2246.</citation>
    <PMID>22281799</PMID>
  </results_reference>
  <results_reference>
    <citation>Li L, Luo W, Huang L, Zhang W, Gao Y, Jiang H, Zhang C, Long L, Chen S. Remote perconditioning reduces myocardial injury in adult valve replacement: a randomized controlled trial. J Surg Res. 2010 Nov;164(1):e21-6. doi: 10.1016/j.jss.2010.06.016. Epub 2010 Jul 2.</citation>
    <PMID>20850778</PMID>
  </results_reference>
  <results_reference>
    <citation>Rahman IA, Mascaro JG, Steeds RP, Frenneaux MP, Nightingale P, Gosling P, Townsend P, Townend JN, Green D, Bonser RS. Remote ischemic preconditioning in human coronary artery bypass surgery: from promise to disappointment? Circulation. 2010 Sep 14;122(11 Suppl):S53-9. doi: 10.1161/CIRCULATIONAHA.109.926667.</citation>
    <PMID>20837926</PMID>
  </results_reference>
  <verification_date>January 2017</verification_date>
  <study_first_submitted>January 7, 2017</study_first_submitted>
  <study_first_submitted_qc>January 7, 2017</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 10, 2017</study_first_posted>
  <last_update_submitted>February 19, 2017</last_update_submitted>
  <last_update_submitted_qc>February 19, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">February 23, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Xuzhou Medical University</investigator_affiliation>
    <investigator_full_name>Su Liu</investigator_full_name>
    <investigator_title>Principal Investigator</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Lung Injury</mesh_term>
    <mesh_term>Ischemia</mesh_term>
    <mesh_term>Wounds and Injuries</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
    <ipd_description>IPD will be available when this trial is finished and the article have been published.</ipd_description>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03016182
org study id: XYFY-2017-004
nct id: NCT03016182
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
During cardiac surgery with cardiopulmonary bypass , pulmonary dysfunction remains to be a
      problem complicating the postoperative course of the patients.Remote ischemic
      preconditioning(RIPC) with transient upper limb ischemia/reperfusion is a novel, simple,
      cost-free,non-pharmacological and non-invasive strategy.Recent several trials suggested that
      RIPC could provide pulmonary protection by reducing serum biomarkers,however,whether the RIPC
      can improve the clinical outcomes in patients undergoing on-pump cardiac surgery,is still
      uncertain.

      The study hypothesis is: remote ischemic preconditioning will provide lung-protective effect
      and improve clinical outcomes in patients undergoing cardic surgery.
Remote ischemic preconditioning (RIPC) protocol will be induced during anesthesia by 3 cycles
      of 5-min upper limb ischemia and 5-min reperfusion using a blood pressure cuff inflated to a
      pressure 200mmHg
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Prevention
masking: Double (Participant, Investigator)
measure: Comparison of PaO2/FiO2 over 24 hours after cardiac surgery
time frame: 24 hours post surgery
measure: All-cause mortality
time frame: 30 days post surgery
measure: Postoperative Pulmonary Complications
time frame: 30 days post surgery
arm group label: Remote Ischemic Preconditioning(RIPC)
arm group type: Active Comparator
description: 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg will be given to RIPC
arm group label: Control
arm group type: Placebo Comparator
description: Control group without remote ischemic preconditioning
intervention type: Procedure
intervention name: Remote Ischemic Preconditioning
description: RIPC will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg
arm group label: Remote Ischemic Preconditioning(RIPC)
other name: RIPC
intervention type: Procedure
intervention name: Control
description: Control group witnout remote ischemic preconditioning
arm group label: Control
criteria: 
gender: All
minimum age: 18 Years
maximum age: 80 Years
healthy volunteers: No
last name: Liu Su, M.D/Ph.D
role: Principal Investigator
affiliation: The Affiliated Hospital of Xuzhou Medical University
last name: Liu Su, M.D/Ph.D
phone: +86-18118309692
email: xyfymzk@163.com
facility: 
status: Recruiting
country: China
citation: Domanski MJ, Mahaffey K, Hasselblad V, Brener SJ, Smith PK, Hillis G, Engoren M, Alexander JH, Levy JH, Chaitman BR, Broderick S, Mack MJ, Pieper KS, Farkouh ME. Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery. JAMA. 2011 Feb 9;305(6):585-91. doi: 10.1001/jama.2011.99.
PMID: 21304084
citation: JENNINGS RB, SOMMERS HM, SMYTH GA, FLACK HA, LINN H. Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. Arch Pathol. 1960 Jul;70:68-78. No abstract available.
PMID: 14407094
citation: Braunwald E, Kloner RA. Myocardial reperfusion: a double-edged sword? J Clin Invest. 1985 Nov;76(5):1713-9. doi: 10.1172/JCI112160. No abstract available.
PMID: 4056048
citation: Sullivan PJ, Sweeney KJ, Hirpara KM, Malone CB, Curtin W, Kerin MJ. Cyclical ischaemic preconditioning modulates the adaptive immune response in human limb ischaemia-reperfusion injury. Br J Surg. 2009 Apr;96(4):381-90. doi: 10.1002/bjs.6554.
PMID: 19283744
citation: Bolli R. The late phase of preconditioning. Circ Res. 2000 Nov 24;87(11):972-83. doi: 10.1161/01.res.87.11.972.
PMID: 11090541
citation: Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 Nov;74(5):1124-36. doi: 10.1161/01.cir.74.5.1124.
PMID: 3769170
citation: Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993 Mar;87(3):893-9. doi: 10.1161/01.cir.87.3.893.
PMID: 7680290
citation: Gho BC, Schoemaker RG, van den Doel MA, Duncker DJ, Verdouw PD. Myocardial protection by brief ischemia in noncardiac tissue. Circulation. 1996 Nov 1;94(9):2193-200. doi: 10.1161/01.cir.94.9.2193.
PMID: 8901671
citation: Oxman T, Arad M, Klein R, Avazov N, Rabinowitz B. Limb ischemia preconditions the heart against reperfusion tachyarrhythmia. Am J Physiol. 1997 Oct;273(4):H1707-12. doi: 10.1152/ajpheart.1997.273.4.H1707.
PMID: 9362234
citation: Li G, Labruto F, Sirsjo A, Chen F, Vaage J, Valen G. Myocardial protection by remote preconditioning: the role of nuclear factor kappa-B p105 and inducible nitric oxide synthase. Eur J Cardiothorac Surg. 2004 Nov;26(5):968-73. doi: 10.1016/j.ejcts.2004.06.015.
PMID: 15519191
citation: Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, Vogel M, Sorensen K, Redington AN, MacAllister R. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation. 2002 Dec 3;106(23):2881-3. doi: 10.1161/01.cir.0000043806.51912.9b.
PMID: 12460865
citation: Hausenloy DJ, Yellon DM. Remote ischaemic preconditioning: underlying mechanisms and clinical application. Cardiovasc Res. 2008 Aug 1;79(3):377-86. doi: 10.1093/cvr/cvn114. Epub 2008 May 2.
PMID: 18456674
citation: Sivaraman V, Pickard JM, Hausenloy DJ. Remote ischaemic conditioning: cardiac protection from afar. Anaesthesia. 2015 Jun;70(6):732-48. doi: 10.1111/anae.12973. Epub 2015 Feb 26.
PMID: 25961420
citation: Heusch G, Botker HE, Przyklenk K, Redington A, Yellon D. Remote ischemic conditioning. J Am Coll Cardiol. 2015 Jan 20;65(2):177-95. doi: 10.1016/j.jacc.2014.10.031.
PMID: 25593060
citation: Kerendi F, Kin H, Halkos ME, Jiang R, Zatta AJ, Zhao ZQ, Guyton RA, Vinten-Johansen J. Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors. Basic Res Cardiol. 2005 Sep;100(5):404-12. doi: 10.1007/s00395-005-0539-2. Epub 2005 Jun 17.
PMID: 15965583
citation: Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet. 2007 Aug 18;370(9587):575-9. doi: 10.1016/S0140-6736(07)61296-3.
PMID: 17707752
citation: Hammermeister KE, Burchfiel C, Johnson R, Grover FL. Identification of patients at greatest risk for developing major complications at cardiac surgery. Circulation. 1990 Nov;82(5 Suppl):IV380-9. Erratum In: Circulation 1991 Jul;84(1):446.
PMID: 2225429
citation: Messent M, Sullivan K, Keogh BF, Morgan CJ, Evans TW. Adult respiratory distress syndrome following cardiopulmonary bypass: incidence and prediction. Anaesthesia. 1992 Mar;47(3):267-8. doi: 10.1111/j.1365-2044.1992.tb02134.x.
PMID: 1566999
citation: Wan S, LeClerc JL, Vincent JL. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest. 1997 Sep;112(3):676-92. doi: 10.1378/chest.112.3.676.
PMID: 9315800
citation: Kharbanda RK, Li J, Konstantinov IE, Cheung MM, White PA, Frndova H, Stokoe J, Cox P, Vogel M, Van Arsdell G, MacAllister R, Redington AN. Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study. Heart. 2006 Oct;92(10):1506-11. doi: 10.1136/hrt.2004.042366. Epub 2006 Jul 3.
PMID: 16818489
citation: Xia Z, Herijgers P, Nishida T, Ozaki S, Wouters P, Flameng W. Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep. Can J Anaesth. 2003 May;50(5):481-8. doi: 10.1007/BF03021061. English, French.
PMID: 12734158
citation: Cheung MM, Kharbanda RK, Konstantinov IE, Shimizu M, Frndova H, Li J, Holtby HM, Cox PN, Smallhorn JF, Van Arsdell GS, Redington AN. Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol. 2006 Jun 6;47(11):2277-82. doi: 10.1016/j.jacc.2006.01.066. Epub 2006 May 15.
PMID: 16750696
citation: Zhou W, Zeng D, Chen R, Liu J, Yang G, Liu P, Zhou X. Limb ischemic preconditioning reduces heart and lung injury after an open heart operation in infants. Pediatr Cardiol. 2010 Jan;31(1):22-9. doi: 10.1007/s00246-009-9536-9. Epub 2009 Sep 29.
PMID: 19787388
citation: Kim JC, Shim JK, Lee S, Yoo YC, Yang SY, Kwak YL. Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery. Chest. 2012 Aug;142(2):467-475. doi: 10.1378/chest.11-2246.
PMID: 22281799
citation: Li L, Luo W, Huang L, Zhang W, Gao Y, Jiang H, Zhang C, Long L, Chen S. Remote perconditioning reduces myocardial injury in adult valve replacement: a randomized controlled trial. J Surg Res. 2010 Nov;164(1):e21-6. doi: 10.1016/j.jss.2010.06.016. Epub 2010 Jul 2.
PMID: 20850778
citation: Rahman IA, Mascaro JG, Steeds RP, Frenneaux MP, Nightingale P, Gosling P, Townsend P, Townend JN, Green D, Bonser RS. Remote ischemic preconditioning in human coronary artery bypass surgery: from promise to disappointment? Circulation. 2010 Sep 14;122(11 Suppl):S53-9. doi: 10.1161/CIRCULATIONAHA.109.926667.
PMID: 20837926
responsible party type: Principal Investigator
investigator affiliation: Xuzhou Medical University
investigator full name: Su Liu
investigator title: Principal Investigator
mesh term: Lung Injury
mesh term: Ischemia
mesh term: Wounds and Injuries
sharing ipd: No
ipd description: IPD will be available when this trial is finished and the article have been published.