<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03015545</url>
  </required_header>
  <id_info>
    <org_study_id>HSEARS20161117007</org_study_id>
    <nct_id>NCT03015545</nct_id>
  </id_info>
  <brief_title>The Effects of WBV on Muscle Stiffness and Reflex Activity in Stroke.</brief_title>
  <official_title>The Effects of Whole Body Vibration (WBV) on Muscle Stiffness and Reflex Activity in People After Stroke.</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>The Hong Kong Polytechnic University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>The Hong Kong Polytechnic University</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Spastic hypertonia is common after stroke. Whole-body vibration (WBV) is known to have&#xD;
      modulatory effects of muscle reflex activity and blood flow in other populations and thus&#xD;
      have potential applications in the management of spastic hypertonia post-stroke. This study&#xD;
      aims to investigate the acute effect of WBV on leg muscle H-reflex, stiffness, and blood&#xD;
      perfusion in people with chronic stroke.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Spastic hypertonia is common after stroke. Whole-body vibration (WBV) is known to have&#xD;
      modulatory effects of muscle reflex activity and blood flow in other populations and thus&#xD;
      have potential applications in management of spastic hypertonia post-stroke. However, the&#xD;
      potential effects of WBV on leg muscle stiffness in stroke rehabilitation remains unknown.&#xD;
      Scientific evidence is warranted to fill the knowledge gap.&#xD;
&#xD;
      Purpose This study aims to investigate the acute effect of WBV on leg muscle H-reflex,&#xD;
      stiffness and blood perfusion in people with chronic stroke.&#xD;
&#xD;
      Methods Individuals with chronic stroke will be recruited from community self-help groups and&#xD;
      existing patient database. Relevant information (e.g. demographic information, medical&#xD;
      history) will be obtained from medical records and subject interviews. Each subject will have&#xD;
      to fulfill the following inclusion criteria: (1) diagnosis of chronic stroke, (2)&#xD;
      community-dwelling, (3) able to follow simple verbal instructions. Exclusion criteria are:&#xD;
      (1) other diagnoses of neurological conditions, (2) significant musculoskeletal conditions&#xD;
      (e.g. amputations), (3) metal implants in the lower extremity or spine, (4) recent fracture&#xD;
      in the lower extremity, (5) diagnosis of osteoporosis, (6) vestibular disorders, (7)&#xD;
      peripheral vascular disease, and (11) other serious illnesses or contraindications to&#xD;
      exercise.&#xD;
&#xD;
      This is a single-blinded randomized within-patient cross-over study. Each participant was&#xD;
      evaluated for the soleus H-reflex, stiffness and blood perfusion of the medial gastrocnemius&#xD;
      (MG) using ultrasound on both sides before and after either a 5-minute WBV intervention (30&#xD;
      Hertz, 1.5mm, knee flexed 60 degrees) or a no-WBV condition (5 minutes). The measurements&#xD;
      were performed at baseline and every 1-min post-intervention up to 5 minutes. The outcomes&#xD;
      generated included the soleus H/M ratio, shear modulus and vascular index (VI) of the MG&#xD;
      muscle.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">May 1, 2017</start_date>
  <completion_date type="Actual">December 31, 2017</completion_date>
  <primary_completion_date type="Actual">September 3, 2017</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Crossover Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>H-reflex of paretic soleus muscle</measure>
    <time_frame>Immediately before the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of paretic soleus muscle</measure>
    <time_frame>1st minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of paretic soleus muscle</measure>
    <time_frame>2nd minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of paretic soleus muscle</measure>
    <time_frame>3rd minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of paretic soleus muscle</measure>
    <time_frame>4th minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of paretic soleus muscle</measure>
    <time_frame>5th minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of paretic medial gastrocnemius</measure>
    <time_frame>Immediately before the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of paretic medial gastrocnemius</measure>
    <time_frame>1st minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of paretic medial gastrocnemius</measure>
    <time_frame>2nd minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of paretic medial gastrocnemius</measure>
    <time_frame>3rd minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of paretic medial gastrocnemius</measure>
    <time_frame>4th minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of paretic medial gastrocnemius</measure>
    <time_frame>5th minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of non-paretic soleus muscle</measure>
    <time_frame>Immediately before the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of non-paretic soleus muscle</measure>
    <time_frame>1st minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of non-paretic soleus muscle</measure>
    <time_frame>2nd minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of non-paretic soleus muscle</measure>
    <time_frame>3rd minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of non-paretic soleus muscle</measure>
    <time_frame>4th minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>H-reflex of non-paretic soleus muscle</measure>
    <time_frame>5th minute after the intervention</time_frame>
    <description>To measure the efficacy of synaptic transmission</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of non-paretic medial gastrocnemius</measure>
    <time_frame>Immediately before the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of non-paretic medial gastrocnemius</measure>
    <time_frame>1st minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of non-paretic medial gastrocnemius</measure>
    <time_frame>2nd minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of non-paretic medial gastrocnemius</measure>
    <time_frame>3th minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of non-paretic medial gastrocnemius</measure>
    <time_frame>4th minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Muscle stiffness of non-paretic medial gastrocnemius</measure>
    <time_frame>5th minute after the intervention</time_frame>
    <description>Measured by Supersonic elastography with ankle in neutral position</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of paretic medial gastrocnemius muscle</measure>
    <time_frame>Immediately before the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of paretic medial gastrocnemius muscle</measure>
    <time_frame>1 minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of paretic medial gastrocnemius muscle</measure>
    <time_frame>2nd minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of paretic medial gastrocnemius muscle</measure>
    <time_frame>3rd minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of paretic medial gastrocnemius muscle</measure>
    <time_frame>4th minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of paretic medial gastrocnemius muscle</measure>
    <time_frame>5th minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle</measure>
    <time_frame>Immediately before the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle</measure>
    <time_frame>1th minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle</measure>
    <time_frame>2nd minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle</measure>
    <time_frame>3rd minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>MoviIntramuscular blood perfusion of non-paretic medial gastrocnemius muscle</measure>
    <time_frame>4th minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle</measure>
    <time_frame>5th minute after the intervention</time_frame>
    <description>Measured by power Doppler ultrasound</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Fugl-Meyer Assessment of Motor Recovery after Stroke--lower extremities</measure>
    <time_frame>Immediately before the intervention</time_frame>
    <description>Evaluates and measures motor recovery in post-stroke hemiplegic patients</description>
  </other_outcome>
  <other_outcome>
    <measure>Brief Balance Evaluation Systems Test</measure>
    <time_frame>Immediately before the intervention</time_frame>
  </other_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">36</enrollment>
  <condition>Stroke</condition>
  <arm_group>
    <arm_group_label>Control</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>This group will stand with knee flexion 60 degrees on the same vibration platform for 60 seconds for 5 times with 60-seconds rest interval, but no vibration will be given.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>High intensity whole body vibration</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>This group will stand with knee flexion 60 degrees on the same vibration platform for 60 seconds for 5 times with 60-seconds rest interval. The whole body vibration platform will be set with frequency at 30Hz and amplitude at 1.5mm.</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>paretic leg-control</intervention_name>
    <description>standing on the vibration platform, with no vibration signals delivered.</description>
    <arm_group_label>Control</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>paretic leg-WBV</intervention_name>
    <description>standing on the vibration platform, with WBV at 30Hz, 1.5mm.</description>
    <arm_group_label>High intensity whole body vibration</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>non-paretic leg-control</intervention_name>
    <description>standing on the vibration platform, with no vibration signals delivered.</description>
    <arm_group_label>Control</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>non-paretic leg-WBV</intervention_name>
    <description>standing on the vibration platform, with WBV at 30Hz, 1.5mm.</description>
    <arm_group_label>High intensity whole body vibration</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. Adult with a diagnosis of a hemispheric stroke &gt;6 months,&#xD;
&#xD;
          2. Medically stable,&#xD;
&#xD;
          3. Able to stand independently for at least 1 minute and&#xD;
&#xD;
          4. Mas score &gt;1 measured at the ankle plantar flexors.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Brainstem or cerebellar stroke,&#xD;
&#xD;
          2. Other neurological condition,&#xD;
&#xD;
          3. Serious musculoskeletal or cardiovascular disease,&#xD;
&#xD;
          4. Severe contracture of the ankle that the cannot be put in the neutral position.&#xD;
&#xD;
          5. Metal implants or recent fractures in the lower extremities or spine,&#xD;
&#xD;
          6. Fresh skin wound in lower extremities, especially popliteal fossa&#xD;
&#xD;
          7. Other severe illnesses or contraindication for exercise.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Hector WH Tsang, PhD</last_name>
    <role>Study Chair</role>
    <affiliation>Department of Rehabilitation Sciences, The Hong Kong Polytechnic University</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>The Hong Kong Polytechnic University</name>
      <address>
        <city>Hung Hom</city>
        <state>Kowloon</state>
        <country>Hong Kong</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Hong Kong</country>
  </location_countries>
  <verification_date>December 2018</verification_date>
  <study_first_submitted>December 29, 2016</study_first_submitted>
  <study_first_submitted_qc>January 6, 2017</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 10, 2017</study_first_posted>
  <last_update_submitted>December 7, 2018</last_update_submitted>
  <last_update_submitted_qc>December 7, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">December 10, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>The Hong Kong Polytechnic University</investigator_affiliation>
    <investigator_full_name>Marco Yiu-Chung Pang</investigator_full_name>
    <investigator_title>Professor</investigator_title>
  </responsible_party>
  <keyword>Muscle Stiffness</keyword>
  <keyword>Ultrasound elastography</keyword>
  <keyword>H-reflex</keyword>
  <keyword>Whole body vibration</keyword>
  <keyword>blood perfusion</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Stroke</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03015545
org study id: HSEARS20161117007
nct id: NCT03015545
lead sponsor: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
Spastic hypertonia is common after stroke. Whole-body vibration (WBV) is known to have
      modulatory effects of muscle reflex activity and blood flow in other populations and thus
      have potential applications in the management of spastic hypertonia post-stroke. This study
      aims to investigate the acute effect of WBV on leg muscle H-reflex, stiffness, and blood
      perfusion in people with chronic stroke.
Spastic hypertonia is common after stroke. Whole-body vibration (WBV) is known to have
      modulatory effects of muscle reflex activity and blood flow in other populations and thus
      have potential applications in management of spastic hypertonia post-stroke. However, the
      potential effects of WBV on leg muscle stiffness in stroke rehabilitation remains unknown.
      Scientific evidence is warranted to fill the knowledge gap.

      Purpose This study aims to investigate the acute effect of WBV on leg muscle H-reflex,
      stiffness and blood perfusion in people with chronic stroke.

      Methods Individuals with chronic stroke will be recruited from community self-help groups and
      existing patient database. Relevant information (e.g. demographic information, medical
      history) will be obtained from medical records and subject interviews. Each subject will have
      to fulfill the following inclusion criteria: (1) diagnosis of chronic stroke, (2)
      community-dwelling, (3) able to follow simple verbal instructions. Exclusion criteria are:
      (1) other diagnoses of neurological conditions, (2) significant musculoskeletal conditions
      (e.g. amputations), (3) metal implants in the lower extremity or spine, (4) recent fracture
      in the lower extremity, (5) diagnosis of osteoporosis, (6) vestibular disorders, (7)
      peripheral vascular disease, and (11) other serious illnesses or contraindications to
      exercise.

      This is a single-blinded randomized within-patient cross-over study. Each participant was
      evaluated for the soleus H-reflex, stiffness and blood perfusion of the medial gastrocnemius
      (MG) using ultrasound on both sides before and after either a 5-minute WBV intervention (30
      Hertz, 1.5mm, knee flexed 60 degrees) or a no-WBV condition (5 minutes). The measurements
      were performed at baseline and every 1-min post-intervention up to 5 minutes. The outcomes
      generated included the soleus H/M ratio, shear modulus and vascular index (VI) of the MG
      muscle.
allocation: Randomized
intervention model: Crossover Assignment
primary purpose: Treatment
masking: Single (Outcomes Assessor)
measure: H-reflex of paretic soleus muscle
time frame: Immediately before the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of paretic soleus muscle
time frame: 1st minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of paretic soleus muscle
time frame: 2nd minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of paretic soleus muscle
time frame: 3rd minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of paretic soleus muscle
time frame: 4th minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of paretic soleus muscle
time frame: 5th minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: Muscle stiffness of paretic medial gastrocnemius
time frame: Immediately before the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of paretic medial gastrocnemius
time frame: 1st minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of paretic medial gastrocnemius
time frame: 2nd minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of paretic medial gastrocnemius
time frame: 3rd minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of paretic medial gastrocnemius
time frame: 4th minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of paretic medial gastrocnemius
time frame: 5th minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: H-reflex of non-paretic soleus muscle
time frame: Immediately before the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of non-paretic soleus muscle
time frame: 1st minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of non-paretic soleus muscle
time frame: 2nd minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of non-paretic soleus muscle
time frame: 3rd minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of non-paretic soleus muscle
time frame: 4th minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: H-reflex of non-paretic soleus muscle
time frame: 5th minute after the intervention
description: To measure the efficacy of synaptic transmission
measure: Muscle stiffness of non-paretic medial gastrocnemius
time frame: Immediately before the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of non-paretic medial gastrocnemius
time frame: 1st minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of non-paretic medial gastrocnemius
time frame: 2nd minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of non-paretic medial gastrocnemius
time frame: 3th minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of non-paretic medial gastrocnemius
time frame: 4th minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Muscle stiffness of non-paretic medial gastrocnemius
time frame: 5th minute after the intervention
description: Measured by Supersonic elastography with ankle in neutral position
measure: Intramuscular blood perfusion of paretic medial gastrocnemius muscle
time frame: Immediately before the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of paretic medial gastrocnemius muscle
time frame: 1 minute after the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of paretic medial gastrocnemius muscle
time frame: 2nd minute after the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of paretic medial gastrocnemius muscle
time frame: 3rd minute after the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of paretic medial gastrocnemius muscle
time frame: 4th minute after the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of paretic medial gastrocnemius muscle
time frame: 5th minute after the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle
time frame: Immediately before the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle
time frame: 1th minute after the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle
time frame: 2nd minute after the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle
time frame: 3rd minute after the intervention
description: Measured by power Doppler ultrasound
measure: MoviIntramuscular blood perfusion of non-paretic medial gastrocnemius muscle
time frame: 4th minute after the intervention
description: Measured by power Doppler ultrasound
measure: Intramuscular blood perfusion of non-paretic medial gastrocnemius muscle
time frame: 5th minute after the intervention
description: Measured by power Doppler ultrasound
measure: Fugl-Meyer Assessment of Motor Recovery after Stroke--lower extremities
time frame: Immediately before the intervention
description: Evaluates and measures motor recovery in post-stroke hemiplegic patients
measure: Brief Balance Evaluation Systems Test
time frame: Immediately before the intervention
arm group label: Control
arm group type: Active Comparator
description: This group will stand with knee flexion 60 degrees on the same vibration platform for 60 seconds for 5 times with 60-seconds rest interval, but no vibration will be given.
arm group label: High intensity whole body vibration
arm group type: Active Comparator
description: This group will stand with knee flexion 60 degrees on the same vibration platform for 60 seconds for 5 times with 60-seconds rest interval. The whole body vibration platform will be set with frequency at 30Hz and amplitude at 1.5mm.
intervention type: Device
intervention name: paretic leg-control
description: standing on the vibration platform, with no vibration signals delivered.
arm group label: Control
intervention type: Device
intervention name: paretic leg-WBV
description: standing on the vibration platform, with WBV at 30Hz, 1.5mm.
arm group label: High intensity whole body vibration
intervention type: Device
intervention name: non-paretic leg-control
description: standing on the vibration platform, with no vibration signals delivered.
arm group label: Control
intervention type: Device
intervention name: non-paretic leg-WBV
description: standing on the vibration platform, with WBV at 30Hz, 1.5mm.
arm group label: High intensity whole body vibration
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Hector WH Tsang, PhD
role: Study Chair
affiliation: Department of Rehabilitation Sciences, The Hong Kong Polytechnic University
facility: 
country: Hong Kong
responsible party type: Principal Investigator
investigator affiliation: The Hong Kong Polytechnic University
investigator full name: Marco Yiu-Chung Pang
investigator title: Professor
mesh term: Stroke
sharing ipd: No