<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03018262</url>
  </required_header>
  <id_info>
    <org_study_id>170031</org_study_id>
    <secondary_id>17-N-0031</secondary_id>
    <nct_id>NCT03018262</nct_id>
  </id_info>
  <brief_title>Neurophysiology of Surround Inhibition in the Human Motor Cortex</brief_title>
  <official_title>Detailed Evaluation of the Neurophysiology of Surround Inhibition in the Human Motor Cortex</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>National Institute of Neurological Disorders and Stroke (NINDS)</agency>
      <agency_class>NIH</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>National Institutes of Health Clinical Center (CC)</source>
  <oversight_info>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>Yes</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      Background:&#xD;
&#xD;
      Movement disorders have many different causes and symptoms. Researchers still do not fully&#xD;
      understand which parts of the brain are involved in fine movement. They want to learn about&#xD;
      which brain regions could be abnormal in people with movement disorders.&#xD;
&#xD;
      Objective:&#xD;
&#xD;
      To better understand how the brain controls movement.&#xD;
&#xD;
      Eligibility:&#xD;
&#xD;
      Healthy, right-handed adults age 18-70 years old.&#xD;
&#xD;
      Design:&#xD;
&#xD;
      Participants will be screened with a physical exam and questions about their handedness. They&#xD;
      may have a urine test.&#xD;
&#xD;
      Participants will have 1 or 2 clinic visits. The first visit will last about 1.5 hours. The&#xD;
      second will last about 3 hours.&#xD;
&#xD;
      Participants will have structural magnetic resonance imaging (MRI). A strong magnetic field&#xD;
      and radio waves take pictures of the brain. Participants will lie on a table that slides in&#xD;
      and out of a metal cylinder.&#xD;
&#xD;
      Participants may have transcranial magnetic stimulation. A wire coil is held on the scalp. A&#xD;
      brief electrical current is passed through the coil and creates a magnetic pulse that&#xD;
      stimulates the brain. Participants will wear a pair of glasses or a headband with small&#xD;
      sensors so researchers can track head position.&#xD;
&#xD;
      Participants will perform a simple index finger movement task.&#xD;
&#xD;
      Participants may have surface electromyography from at least two hand muscles. Small metal&#xD;
      disk or adhesive pad electrodes will be taped to the skin. Participants will be seated in a&#xD;
      comfortable chair with their hands placed on a pillow.&#xD;
&#xD;
      Participants may have an electroencephalography. A cap with small disc electrodes will be&#xD;
      placed on the scalp.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Objectives:&#xD;
&#xD;
      The purpose of this protocol is to improve understanding of the neurophysiological mechanisms&#xD;
      that underlie the phenomenon of surround inhibition in the human motor cortex. It is known&#xD;
      that patients with focal hand dystonia have abnormal motor surround inhibition. However, the&#xD;
      physiology of this phenomenon still remains unclear. The 3 sub-studies proposed under this&#xD;
      protocol will integrate several neurophysiological techniques to explore different aspects of&#xD;
      motor surround inhibition. The objectives of sub-study 1 are (a) to identify the EEG&#xD;
      correlate of motor SI (b) to determine the relationship between short interval intracortical&#xD;
      inhibition (SICI) and SI, both of which are compromised in patients with FHD and (c) to&#xD;
      determine if there is an oscillatory frequency band that is relevant for SI. The results from&#xD;
      this sub-study will shed light on the inhibitory mechanisms that are critical for motor SI.&#xD;
      Sub-study 2 is aimed at determining the influence of parietal conditioning on motor surround&#xD;
      inhibition. If conditioning the parietal cortex enhances SI, we can conclude that the&#xD;
      parieto-motor inhibitory network may be involved in motor SI and that this network could be&#xD;
      affected in focal hand dystonia. Sub-study 3 will explore SI during different motor tasks.&#xD;
&#xD;
      Study population:&#xD;
&#xD;
      We intend to study up to 95 healthy volunteers in total. Up to 30 participants will be&#xD;
      recruited for sub-study 1, 35 for sub-study 2, and 30 for sub-study 3.&#xD;
&#xD;
      Design:&#xD;
&#xD;
      Sub-study 1: This will be an exploratory study. Participants will perform an auditory cued&#xD;
      index finger movement task and motor evoked potentials will be elicited by stimulating the&#xD;
      motor hotspot of a surround muscle using transcranial magnetic stimulation (TMS). EEG will be&#xD;
      recorded continuously. Single or paired TMS pulses (with postero-anterior or antero-posterior&#xD;
      current) will be delivered either while the subject is at rest or at movement onset.&#xD;
      TMS-evoked potentials (TEPs) will be obtained by time-locked averaging of all the trials in&#xD;
      each condition. The amplitudes of the different peaks of the TEP will be compared across&#xD;
      conditions which may be correlated with the degree of SI or SICI. The components of the TEP&#xD;
      that are most relevant to motor SI will thus be identified.&#xD;
&#xD;
      Sub-study 2: This will be a hypothesis-driven study. Our primary hypothesis is that parietal&#xD;
      conditioning will influence motor SI in healthy volunteers. Participants will perform an&#xD;
      auditory cued index finger movement task and motor evoked potentials will be elicited by&#xD;
      stimulating the motor hotspot of a surround muscle using transcranial magnetic stimulation.&#xD;
      Two coils, one positioned over the motor cortex and the other over an inhibitory region of&#xD;
      the inferior parietal lobule, will deliver TMS pulses at a fixed inter-stimulus interval. The&#xD;
      pulses will be delivered either while the subject is at rest or at movement onset. The ratio&#xD;
      of mean MEP amplitude obtained with parietal conditioning to that obtained with motor cortex&#xD;
      stimulation alone at movement onset will reveal any parieto-motor influence on SI.&#xD;
&#xD;
      Sub-study 3: This will be an exploratory study. Participants will be asked to perform&#xD;
      different motor tasks such as activating an intrinsic hand muscle at different levels of&#xD;
      activation, sequential muscle activation or more complex tasks such as writing. Single TMS&#xD;
      pulses will be delivered at primary motor cortex at rest, at the onset of the motor tasks or&#xD;
      during the motor tasks. MEPs will be measured in the active and surround muscles. The ratios&#xD;
      of MEP amplitudes during different levels of activation in the active and surround muscles&#xD;
      will reveal&#xD;
&#xD;
      modulation of SI during these tasks.&#xD;
&#xD;
      Outcome measures:&#xD;
&#xD;
      For sub-study 1, our outcome measures will be (1) amplitudes of the different TEP peaks (2)&#xD;
      degree of surround inhibition and short interval intracortical inhibition (3) correlation&#xD;
      between them and relevant peak amplitudes (4) power and cortico-cortical coherence at&#xD;
      different frequency bands.&#xD;
&#xD;
      MEP amplitude will be the primary outcome measure in sub-study 2 and 3.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">February 7, 2017</start_date>
  <completion_date type="Actual">March 24, 2021</completion_date>
  <primary_completion_date type="Actual">March 24, 2021</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Substudy 2 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single /paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.</measure>
    <time_frame>throughout</time_frame>
    <description>TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Substudy 1 EEG analysis: we will measure the latency and amplitude of the different components of the TMS-evoked potentials</measure>
    <time_frame>throughout</time_frame>
    <description>EEG: For the EEG analysis, we will measure the latency and amplitude of the different components of the TMS-evoked potentials. Time-frequency analysis on the collected EEG data will provide valuable information on which frequency bands are involved in the phenomenon of motor SI. The coherence calculated between relevant brain regions will also reveal information on the changes in cortical connectivity during the phenomenon of SI.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Substudy 1 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal</measure>
    <time_frame>throughout</time_frame>
    <description>TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS will give information about the corticospinal excitability. The latency of the MEP will revealmore information on which neuronal networks were activated.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Substudy 3 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability.</measure>
    <time_frame>throughout</time_frame>
    <description>TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Substudy 3 EMG: The EMG amplitude during certain tasks will reveal information about the level of muscle activation.</measure>
    <time_frame>throughout</time_frame>
    <description>EMG: The EMG amplitude during certain tasks will reveal information about the level of muscle activation.</description>
  </primary_outcome>
  <number_of_groups>3</number_of_groups>
  <enrollment type="Actual">53</enrollment>
  <condition>Normal Physiology</condition>
  <arm_group>
    <arm_group_label>Healthy Volunteers - Sub-study 1</arm_group_label>
    <description>Healthy Volunteers</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Healthy Volunteers - Sub-study 2</arm_group_label>
    <description>Healthy Volunteers</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Healthy Volunteers - Sub-study 3</arm_group_label>
    <description>Healthy Volunteers</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>TMS - sub-study 1</intervention_name>
    <description>TMS pulses will be applied to the motor hotspot of the surround muscle to identify the TMS-evoked potentials corresponding to motor surround inhibition (SI)</description>
    <arm_group_label>Healthy Volunteers - Sub-study 1</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>TMS - sub-study 2</intervention_name>
    <description>TMS will be used to stimulate the motor cortex and an inhibitory region of the inferior parietal lobe</description>
    <arm_group_label>Healthy Volunteers - Sub-study 2</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>TMS - sub-study 3</intervention_name>
    <description>TMS pulses will be delivered to the primary motor cortex at rest, at the onset of the motor task, or during the motor task</description>
    <arm_group_label>Healthy Volunteers - Sub-study 3</arm_group_label>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        Healthy Volunteers&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        -  INCLUSION CRITERIA:&#xD;
&#xD;
          -  Age between 18 - 70 years.&#xD;
&#xD;
          -  Right-handed (tested by the Edinburg handedness inventory).&#xD;
&#xD;
          -  Able to give informed consent.&#xD;
&#xD;
          -  Able to comply with all study procedures.&#xD;
&#xD;
          -  Abstain from alcohol for at least 48 hrs prior to the study and caffeine on the day of&#xD;
             the study (based on oral interview).&#xD;
&#xD;
        EXCLUSION CRITERIA:&#xD;
&#xD;
          -  Illegal drug use within the past 6 months based on history alone. The intent is to&#xD;
             exclude those with drug use that may affect study results.&#xD;
&#xD;
          -  Self-reported consumption of &gt;14 alcoholic drinks/week for a man and &gt;7 alcoholic&#xD;
             drinks/week for a woman.&#xD;
&#xD;
          -  Abnormal findings on neurological examination.&#xD;
&#xD;
          -  History of or current brain tumor, stroke, head trauma with loss of consciousness,&#xD;
             epilepsy or seizures.&#xD;
&#xD;
          -  Current episode of major depression or any major psychiatric illness.&#xD;
&#xD;
          -  Taking medications that act directly on the central nervous system such as&#xD;
             anti-epileptics, anti-histamines, anti-parkinsonian medication, muscle relaxants,&#xD;
             medication for insomnia, anti-depressants, anti-anxiety medication.&#xD;
&#xD;
          -  Presence of any metal in the eye or skull area such as a brain stimulator, shrapnel,&#xD;
             surgical metal, clips in the brain, cochlear implants, metal fragments in the eye.&#xD;
&#xD;
          -  Presence of pacemaker, intracardiac lines, implanted pumps or stimulators or metal&#xD;
             objects inside the eye or skull.&#xD;
&#xD;
          -  Known hearing loss.&#xD;
&#xD;
          -  NIH employees and/or staff.&#xD;
&#xD;
          -  Pregnancy&#xD;
&#xD;
        EXCLUSION CRITERIA for MRI (sub-study 2 only):&#xD;
&#xD;
        We will follow the Clinical Radiology/NMR Center guidelines for MR safety.&#xD;
&#xD;
        Some of the exclusions are:&#xD;
&#xD;
          -  Have non-MRI compatible metal in the body, such as a cardiac pacemaker, brain&#xD;
             stimulator, shrapnel, surgical metal, clips in the brain or on blood vessels, cochlear&#xD;
             implants, artificial heart valves or metal fragments in the eye as these make having&#xD;
             an MRI unsafe.&#xD;
&#xD;
          -  Have metallic dental fillings which are likely to cause MRI artifacts&#xD;
&#xD;
          -  Unable to lie flat on the back for the expected length of the experiment,&#xD;
&#xD;
          -  up to 30 mins.&#xD;
&#xD;
          -  Uncomfortable being in a small space for the expected length of the experiment, up to&#xD;
             30 mins.&#xD;
&#xD;
          -  Pregnancy.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>70 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Mark Hallett, M.D.</last_name>
    <role>Principal Investigator</role>
    <affiliation>National Institute of Neurological Disorders and Stroke (NINDS)</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>National Institutes of Health Clinical Center</name>
      <address>
        <city>Bethesda</city>
        <state>Maryland</state>
        <zip>20892</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <link>
    <url>https://clinicalstudies.info.nih.gov/cgi/detail.cgi?B_2017-N-0031.html</url>
    <description>NIH Clinical Center Detailed Web Page</description>
  </link>
  <verification_date>March 29, 2021</verification_date>
  <study_first_submitted>January 11, 2017</study_first_submitted>
  <study_first_submitted_qc>January 11, 2017</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 12, 2017</study_first_posted>
  <last_update_submitted>July 12, 2021</last_update_submitted>
  <last_update_submitted_qc>July 12, 2021</last_update_submitted_qc>
  <last_update_posted type="Actual">July 13, 2021</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Surround Inhibition</keyword>
  <keyword>Motor Control</keyword>
  <keyword>Transcranial Magnetic Stimulation (TMS)</keyword>
  <keyword>TMS-Evoked Potential</keyword>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03018262
org study id: 170031
secondary id: 17-N-0031
nct id: NCT03018262
lead sponsor: 
is fda regulated drug: No
is fda regulated device: Yes
Background:

      Movement disorders have many different causes and symptoms. Researchers still do not fully
      understand which parts of the brain are involved in fine movement. They want to learn about
      which brain regions could be abnormal in people with movement disorders.

      Objective:

      To better understand how the brain controls movement.

      Eligibility:

      Healthy, right-handed adults age 18-70 years old.

      Design:

      Participants will be screened with a physical exam and questions about their handedness. They
      may have a urine test.

      Participants will have 1 or 2 clinic visits. The first visit will last about 1.5 hours. The
      second will last about 3 hours.

      Participants will have structural magnetic resonance imaging (MRI). A strong magnetic field
      and radio waves take pictures of the brain. Participants will lie on a table that slides in
      and out of a metal cylinder.

      Participants may have transcranial magnetic stimulation. A wire coil is held on the scalp. A
      brief electrical current is passed through the coil and creates a magnetic pulse that
      stimulates the brain. Participants will wear a pair of glasses or a headband with small
      sensors so researchers can track head position.

      Participants will perform a simple index finger movement task.

      Participants may have surface electromyography from at least two hand muscles. Small metal
      disk or adhesive pad electrodes will be taped to the skin. Participants will be seated in a
      comfortable chair with their hands placed on a pillow.

      Participants may have an electroencephalography. A cap with small disc electrodes will be
      placed on the scalp.
Objectives:

      The purpose of this protocol is to improve understanding of the neurophysiological mechanisms
      that underlie the phenomenon of surround inhibition in the human motor cortex. It is known
      that patients with focal hand dystonia have abnormal motor surround inhibition. However, the
      physiology of this phenomenon still remains unclear. The 3 sub-studies proposed under this
      protocol will integrate several neurophysiological techniques to explore different aspects of
      motor surround inhibition. The objectives of sub-study 1 are (a) to identify the EEG
      correlate of motor SI (b) to determine the relationship between short interval intracortical
      inhibition (SICI) and SI, both of which are compromised in patients with FHD and (c) to
      determine if there is an oscillatory frequency band that is relevant for SI. The results from
      this sub-study will shed light on the inhibitory mechanisms that are critical for motor SI.
      Sub-study 2 is aimed at determining the influence of parietal conditioning on motor surround
      inhibition. If conditioning the parietal cortex enhances SI, we can conclude that the
      parieto-motor inhibitory network may be involved in motor SI and that this network could be
      affected in focal hand dystonia. Sub-study 3 will explore SI during different motor tasks.

      Study population:

      We intend to study up to 95 healthy volunteers in total. Up to 30 participants will be
      recruited for sub-study 1, 35 for sub-study 2, and 30 for sub-study 3.

      Design:

      Sub-study 1: This will be an exploratory study. Participants will perform an auditory cued
      index finger movement task and motor evoked potentials will be elicited by stimulating the
      motor hotspot of a surround muscle using transcranial magnetic stimulation (TMS). EEG will be
      recorded continuously. Single or paired TMS pulses (with postero-anterior or antero-posterior
      current) will be delivered either while the subject is at rest or at movement onset.
      TMS-evoked potentials (TEPs) will be obtained by time-locked averaging of all the trials in
      each condition. The amplitudes of the different peaks of the TEP will be compared across
      conditions which may be correlated with the degree of SI or SICI. The components of the TEP
      that are most relevant to motor SI will thus be identified.

      Sub-study 2: This will be a hypothesis-driven study. Our primary hypothesis is that parietal
      conditioning will influence motor SI in healthy volunteers. Participants will perform an
      auditory cued index finger movement task and motor evoked potentials will be elicited by
      stimulating the motor hotspot of a surround muscle using transcranial magnetic stimulation.
      Two coils, one positioned over the motor cortex and the other over an inhibitory region of
      the inferior parietal lobule, will deliver TMS pulses at a fixed inter-stimulus interval. The
      pulses will be delivered either while the subject is at rest or at movement onset. The ratio
      of mean MEP amplitude obtained with parietal conditioning to that obtained with motor cortex
      stimulation alone at movement onset will reveal any parieto-motor influence on SI.

      Sub-study 3: This will be an exploratory study. Participants will be asked to perform
      different motor tasks such as activating an intrinsic hand muscle at different levels of
      activation, sequential muscle activation or more complex tasks such as writing. Single TMS
      pulses will be delivered at primary motor cortex at rest, at the onset of the motor tasks or
      during the motor tasks. MEPs will be measured in the active and surround muscles. The ratios
      of MEP amplitudes during different levels of activation in the active and surround muscles
      will reveal

      modulation of SI during these tasks.

      Outcome measures:

      For sub-study 1, our outcome measures will be (1) amplitudes of the different TEP peaks (2)
      degree of surround inhibition and short interval intracortical inhibition (3) correlation
      between them and relevant peak amplitudes (4) power and cortico-cortical coherence at
      different frequency bands.

      MEP amplitude will be the primary outcome measure in sub-study 2 and 3.
observational model: Cohort
time perspective: Prospective
measure: Substudy 2 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single /paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.
time frame: throughout
description: TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.
measure: Substudy 1 EEG analysis: we will measure the latency and amplitude of the different components of the TMS-evoked potentials
time frame: throughout
description: EEG: For the EEG analysis, we will measure the latency and amplitude of the different components of the TMS-evoked potentials. Time-frequency analysis on the collected EEG data will provide valuable information on which frequency bands are involved in the phenomenon of motor SI. The coherence calculated between relevant brain regions will also reveal information on the changes in cortical connectivity during the phenomenon of SI.
measure: Substudy 1 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal
time frame: throughout
description: TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS will give information about the corticospinal excitability. The latency of the MEP will revealmore information on which neuronal networks were activated.
measure: Substudy 3 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability.
time frame: throughout
description: TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability.
measure: Substudy 3 EMG: The EMG amplitude during certain tasks will reveal information about the level of muscle activation.
time frame: throughout
description: EMG: The EMG amplitude during certain tasks will reveal information about the level of muscle activation.
arm group label: Healthy Volunteers - Sub-study 1
description: Healthy Volunteers
arm group label: Healthy Volunteers - Sub-study 2
description: Healthy Volunteers
arm group label: Healthy Volunteers - Sub-study 3
description: Healthy Volunteers
intervention type: Device
intervention name: TMS - sub-study 1
description: TMS pulses will be applied to the motor hotspot of the surround muscle to identify the TMS-evoked potentials corresponding to motor surround inhibition (SI)
arm group label: Healthy Volunteers - Sub-study 1
intervention type: Device
intervention name: TMS - sub-study 2
description: TMS will be used to stimulate the motor cortex and an inhibitory region of the inferior parietal lobe
arm group label: Healthy Volunteers - Sub-study 2
intervention type: Device
intervention name: TMS - sub-study 3
description: TMS pulses will be delivered to the primary motor cortex at rest, at the onset of the motor task, or during the motor task
arm group label: Healthy Volunteers - Sub-study 3
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: 70 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Mark Hallett, M.D.
role: Principal Investigator
affiliation: National Institute of Neurological Disorders and Stroke (NINDS)
facility: 
country: United States
url: https://clinicalstudies.info.nih.gov/cgi/detail.cgi?B_2017-N-0031.html
description: NIH Clinical Center Detailed Web Page
responsible party type: Sponsor