<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03037476</url>
  </required_header>
  <id_info>
    <org_study_id>STUDY00001782</org_study_id>
    <secondary_id>3U01DA040219-04S1</secondary_id>
    <nct_id>NCT03037476</nct_id>
  </id_info>
  <brief_title>Personalized Health Assessment Related to Medications (Project PHARM)</brief_title>
  <official_title>Personalized Health Assessment Related to Medications (Project PHARM)</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Washington</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>National Institute on Drug Abuse (NIDA)</agency>
      <agency_class>NIH</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Washington</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      This research will adapt an evidence based intervention for alcohol and other drugs and&#xD;
      evaluate its efficacy on Prescription Stimulant Medication (PSM) misuse in a web-based format&#xD;
      for use with college students who have misused PSMs.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      This project proposes to evaluate the efficacy of Screening and Brief Interventions (SBIs)&#xD;
      for reducing college students' PSM misuse through two different routes of screening and&#xD;
      intervention across 9 colleges and universities spanning the United States. The research will&#xD;
      consist of studies designed to 1) conduct focus groups to refine feedback materials (Study&#xD;
      1); 2) Conduct screening through the Registrar's student lists and implement a randomized&#xD;
      controlled trial (RCT) of a web-based PSM intervention at all sites (Study 2); and 3)&#xD;
      Evaluate the impact of the COVID-19 pandemic using the Study 2 sample on non-medical use of&#xD;
      prescription stimulants, prescription opiates, alcohol use, marijuana use, and other&#xD;
      substances during the COVID-19 pandemic, and understand motives, access, mental health&#xD;
      impacts, and college student and young adult experiences during this unprecedented 12 months.&#xD;
&#xD;
      Study 1 consists of conducting up to 5 focus groups of 8-12 people to elicit feedback&#xD;
      regarding the Personalized Feedback Tool and make refinements prior to carrying out Study 2.&#xD;
&#xD;
      In Study 2, students from 9 college campuses are screened for past year PSM misuse. Those&#xD;
      meeting study criteria are invited to complete a web-based baseline survey and are randomized&#xD;
      to either receive the web-based personalized feedback intervention (PFI) or to assessment&#xD;
      only control. Participants complete follow-up assessments at 6 and 12 months post-baseline to&#xD;
      evaluate intervention efficacy. The investigators hypothesize that participants who receive&#xD;
      the PFI will reduce PSM misuse assessed at 6 and 12 month follow-ups. The investigators&#xD;
      further expect reductions in perceived benefits of PSM and perceived descriptive norms for&#xD;
      PSM, and increases in use of alternative behaviors to support academic success, and expect&#xD;
      these changes will mediate impacts on PSM use at follow-ups. Secondary effects of the&#xD;
      intervention on alcohol and marijuana use are also anticipated, and these reductions are&#xD;
      expected to partially mediate PSM outcomes. Finally, PSM motives and demographics as&#xD;
      potential moderators of intervention efficacy will also be explored.&#xD;
&#xD;
      Lastly, in February of 2021, we received approval to modify the aims for Study 3 to evaluate&#xD;
      the impact of the COVID-19 pandemic using the Study 2 sample. In an already consented,&#xD;
      recruited, and well-characterized sample of high-risk young adults reporting poly-substance&#xD;
      use (Study 2 participants, n=843), Study 3 aimed to describe changes in non-medical use of&#xD;
      prescription stimulants, prescription opiates, alcohol use, marijuana use, and other&#xD;
      substances during the COVID-19 pandemic, and understand motives, access, mental health&#xD;
      impacts, and college student and young adult experiences during this unprecedented 12 months.&#xD;
      Specifically, we intend to evaluate changes pre- and post-pandemic in non-medical use of PSM,&#xD;
      non-medical use of prescription opioid medications (POM), alcohol use, and marijuana use, as&#xD;
      well as mood utilizing Study 2 baseline and follow-up data, controlling for intervention&#xD;
      condition and time since last assessment. We also will evaluate student status and living&#xD;
      arrangement as moderators. The investigators hypothesize: (1) Young adults will report less&#xD;
      PSM and less POM during the pandemic compared to pre-pandemic assessments, in part due to&#xD;
      reduced ease of access and a change in motives for use; (2) Given previous findings that&#xD;
      academic motives were 8 of the 9 most frequently endorsed reasons for PSM, and given&#xD;
      perceptions that a move to virtual learning has been less academically challenging, we&#xD;
      hypothesize that academic motives for PSM will decrease significantly during the pandemic&#xD;
      compared to pre-pandemic; (3) Those no longer in school will report less PSM and less POM&#xD;
      during the pandemic compared to pre-pandemic. (4) Those living at home will have decreased&#xD;
      alcohol and marijuana use compared to pre-pandemic. Among those reporting current student&#xD;
      status at the time of the new survey, we will be able to evaluate changes in motives for use,&#xD;
      access, and academic pressure from baseline to present.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">March 30, 2017</start_date>
  <completion_date type="Actual">December 15, 2021</completion_date>
  <primary_completion_date type="Actual">December 15, 2021</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Participant)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Change in Past 6 Month Non-Medical Use of Prescription Stimulant Medication Frequency</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Assesses frequency of non-medical use of prescription stimulant medications. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Change in Past 6 Month Medical Misuse of Prescription Stimulant Medication</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Assesses past 6 month medical misuse of prescription stimulant medication. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Change in Tobacco, Alcohol, Prescription Medications, and Substance Use/Misuse Brief Screen/Assessment Tool (TAPS Tool)</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Assesses problematic use of tobacco, alcohol, prescription, and illicit drugs over the past year and 3 months. Response options included: 0= Never, 1= Less than Monthly, 2= Monthly, 3= Weekly, 4= Daily or Almost Daily. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Change in Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) - Stimulants Only</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Measures past 3 month non-medical use of prescription stimulants and associated negative consequences. Items were summed to create a scale summary score where higher values indicated more problematic use in the past 3 months (min=0, max=40). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Change in Past 6 Month Prescription Stimulant Use Consequence Questionnaire</measure>
    <time_frame>6 and 12 month follow-up</time_frame>
    <description>Assesses negative consequences associated with prescription stimulant misuse over the previous 6 months. A score of &quot;0&quot; indicates that a given consequence did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=19). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Change in Peak Quantity of Alcohol Consumed in Past Month</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Assesses quantity in standard drinks of peak drinking episode of alcohol consumption over the past month. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in Past 6 Month Daily Drinking Questionnaire</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Assesses typical alcohol consumption over the course of a typical week. Responses for number of drinks consumed each day of a typical week were summed to create a summary score of total number of drinks consumed over a typical week. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in Past 6 Month Rutgers Alcohol Problem Index</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Measures negative alcohol-related consequences experienced over the past 6 months. A score of &quot;0&quot; indicates that a given consequence did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=26). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in Past Year, 6 Month, and 30 Day Marijuana Use Frequency</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Items measure typical frequency of marijuana use and number of days used in the past year, 6 months, and 30 days. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in Past 6 Month Rutgers Marijuana Problem Index</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Measures negative marijuana-related consequences experienced over the past 6 months. A score of &quot;0&quot; indicates that a given consequence did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=26). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in Frequency of Past Month Alcohol Consumption</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Assesses frequency (days) of alcohol consumption over the past month (min=0, max=31). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in Typical Quantity in Standard Drinks Consumed on a Typical Occasion in the Past Month</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Assesses typical drinking quantity in standard drinks of alcohol consumed during a typical drinking occasion over the past month. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Change in Past 6 Month Relapse Prevention/Protective Behaviors Scale</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Measures the use of relapse prevention strategies and protective behaviors related to stimulant medication misuse. A score of &quot;0&quot; indicates that a given strategy did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique relapse prevention/protective behavior strategies that occurred in the past 6 months (min=0, max=28). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </other_outcome>
  <other_outcome>
    <measure>Change in Past Year Prescription Stimulant Norms Rating Form</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>Assesses the perceived percentage of students who have misused prescription stimulant medication in the past year. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </other_outcome>
  <other_outcome>
    <measure>Change in Current Semester/Quarter Motivated Strategies for Learning Questionnaire (MSLQ)</measure>
    <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
    <description>A 19-item abbreviated version of the Motivated Strategies for Learning Questionnaire was used to measures the use of different types of learning strategies and academic motivations during the current semester/quarter. Response options ranged from 1=Not at all true of me to 7=Very true of me. Mean scale scores were computed and change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </other_outcome>
  <other_outcome>
    <measure>Change in Cumulative and Last Semester/Quarter Grade Point Average (GPA)</measure>
    <time_frame>6 and 12 month follow-up</time_frame>
    <description>Participants report their cumulative and previous semester/quarter GPA. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
  </other_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">843</enrollment>
  <condition>Feedback, Psychological</condition>
  <condition>Clinical Trial</condition>
  <condition>Substance Abuse</condition>
  <arm_group>
    <arm_group_label>Web-Based PFI</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Assessment Only</arm_group_label>
    <arm_group_type>Other</arm_group_type>
    <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.</description>
  </arm_group>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Web-based PFI</intervention_name>
    <description>A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
    <arm_group_label>Web-Based PFI</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Assessment Only</intervention_name>
    <description>The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
    <arm_group_label>Assessment Only</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Study 1 Inclusion Criteria:&#xD;
&#xD;
          -  Provides consent to participate&#xD;
&#xD;
          -  Currently enrolled as a student at one of the participating campuses&#xD;
&#xD;
          -  Between 18-25 year olds&#xD;
&#xD;
          -  Misuse of prescription stimulants in the past year&#xD;
&#xD;
        Study 1 Exclusion Criteria:&#xD;
&#xD;
          -  There are no exclusion criteria other than not meeting inclusion criteria.&#xD;
&#xD;
        Study 2 Inclusion Criteria:&#xD;
&#xD;
          -  Provides consent to participate&#xD;
&#xD;
          -  Currently enrolled as a student at one of the participating campuses and in their&#xD;
             second semester/quarter or later&#xD;
&#xD;
          -  Has an anticipated graduation date at least 12 months into the future&#xD;
&#xD;
          -  Between 18-25 year olds&#xD;
&#xD;
          -  Misuse of prescription stimulants in the past year&#xD;
&#xD;
        Study 2 Exclusion Criteria:&#xD;
&#xD;
          -  There are no exclusion criteria other than not meeting inclusion criteria.&#xD;
&#xD;
        Study 3 Inclusion Criteria:&#xD;
&#xD;
          -  Provides consent to participate&#xD;
&#xD;
          -  Previous participation as a Study 2 participant.&#xD;
&#xD;
        Study 3 Exclusion Criteria:&#xD;
&#xD;
          -  There are no exclusion criteria other than not meeting inclusion criteria.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>25 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>University of Washington</name>
      <address>
        <city>Seattle</city>
        <state>Washington</state>
        <zip>98105</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <verification_date>July 2023</verification_date>
  <study_first_submitted>January 5, 2017</study_first_submitted>
  <study_first_submitted_qc>January 27, 2017</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 31, 2017</study_first_posted>
  <results_first_submitted>May 18, 2023</results_first_submitted>
  <results_first_submitted_qc>July 7, 2023</results_first_submitted_qc>
  <results_first_posted type="Actual">August 1, 2023</results_first_posted>
  <disposition_first_submitted>December 14, 2022</disposition_first_submitted>
  <disposition_first_submitted_qc>January 5, 2023</disposition_first_submitted_qc>
  <disposition_first_posted type="Actual">January 12, 2023</disposition_first_posted>
  <last_update_submitted>July 7, 2023</last_update_submitted>
  <last_update_submitted_qc>July 7, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">August 1, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>University of Washington</investigator_affiliation>
    <investigator_full_name>Jason Kilmer</investigator_full_name>
    <investigator_title>Associate Professor, School of Medicine: Psychiatry</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Substance-Related Disorders</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <provided_document_section>
    <provided_document>
      <document_type>Study Protocol and Statistical Analysis Plan</document_type>
      <document_has_protocol>Yes</document_has_protocol>
      <document_has_icf>No</document_has_icf>
      <document_has_sap>Yes</document_has_sap>
      <document_date>August 23, 2019</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/76/NCT03037476/Prot_SAP_000.pdf</document_url>
    </provided_document>
    <provided_document>
      <document_type>Informed Consent Form</document_type>
      <document_has_protocol>No</document_has_protocol>
      <document_has_icf>Yes</document_has_icf>
      <document_has_sap>No</document_has_sap>
      <document_date>January 11, 2019</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/76/NCT03037476/ICF_001.pdf</document_url>
    </provided_document>
  </provided_document_section>

  <clinical_results>

    <participant_flow>
      <group_list>
        <group group_id="P1">
          <title>Web-Based PFI</title>
          <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
        </group>
        <group group_id="P2">
          <title>Assessment Only</title>
          <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
        </group>
      </group_list>
      <period_list>
        <period>
          <title>Overall Study</title>
          <milestone_list>
            <milestone>
              <title>STARTED</title>
              <participants_list>
                <participants group_id="P1" count="414"/>
                <participants group_id="P2" count="429"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="351"/>
                <participants group_id="P2" count="383"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>NOT COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="63"/>
                <participants group_id="P2" count="46"/>
              </participants_list>
            </milestone>
          </milestone_list>
          <drop_withdraw_reason_list>
            <drop_withdraw_reason>
              <title>Lost to Follow-up</title>
              <participants_list>
                <participants group_id="P1" count="63"/>
                <participants group_id="P2" count="46"/>
              </participants_list>
            </drop_withdraw_reason>
          </drop_withdraw_reason_list>
        </period>
      </period_list>
    </participant_flow>

    <baseline>
      <group_list>
        <group group_id="B1">
          <title>Web-Based PFI</title>
          <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
        </group>
        <group group_id="B2">
          <title>Assessment Only</title>
          <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
        </group>
        <group group_id="B3">
          <title>Total</title>
          <description>Total of all reporting groups</description>
        </group>
      </group_list>
      <analyzed_list>
        <analyzed>
          <units>Participants</units>
          <scope>Overall</scope>
          <count_list>
            <count group_id="B1" value="414"/>
            <count group_id="B2" value="429"/>
            <count group_id="B3" value="843"/>
          </count_list>
        </analyzed>
      </analyzed_list>
      <measure_list>
        <measure>
          <title>Age</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>&lt;=18 years</title>
                  <measurement_list>
                    <measurement group_id="B1" value="45"/>
                    <measurement group_id="B2" value="31"/>
                    <measurement group_id="B3" value="76"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Between 18 and 65 years</title>
                  <measurement_list>
                    <measurement group_id="B1" value="369"/>
                    <measurement group_id="B2" value="398"/>
                    <measurement group_id="B3" value="767"/>
                  </measurement_list>
                </category>
                <category>
                  <title>&gt;=65 years</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Age</title>
          <units>years</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="19.82" spread="1.12"/>
                    <measurement group_id="B2" value="19.95" spread="1.05"/>
                    <measurement group_id="B3" value="19.88" spread="1.09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Sex: Female, Male</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>Female</title>
                  <measurement_list>
                    <measurement group_id="B1" value="258"/>
                    <measurement group_id="B2" value="248"/>
                    <measurement group_id="B3" value="506"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Male</title>
                  <measurement_list>
                    <measurement group_id="B1" value="156"/>
                    <measurement group_id="B2" value="181"/>
                    <measurement group_id="B3" value="337"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Ethnicity (NIH/OMB)</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>Hispanic or Latino</title>
                  <measurement_list>
                    <measurement group_id="B1" value="46"/>
                    <measurement group_id="B2" value="41"/>
                    <measurement group_id="B3" value="87"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Not Hispanic or Latino</title>
                  <measurement_list>
                    <measurement group_id="B1" value="366"/>
                    <measurement group_id="B2" value="388"/>
                    <measurement group_id="B3" value="754"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Unknown or Not Reported</title>
                  <measurement_list>
                    <measurement group_id="B1" value="2"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="2"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Race (NIH/OMB)</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>American Indian or Alaska Native</title>
                  <measurement_list>
                    <measurement group_id="B1" value="2"/>
                    <measurement group_id="B2" value="3"/>
                    <measurement group_id="B3" value="5"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Asian</title>
                  <measurement_list>
                    <measurement group_id="B1" value="81"/>
                    <measurement group_id="B2" value="88"/>
                    <measurement group_id="B3" value="169"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Native Hawaiian or Other Pacific Islander</title>
                  <measurement_list>
                    <measurement group_id="B1" value="1"/>
                    <measurement group_id="B2" value="3"/>
                    <measurement group_id="B3" value="4"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Black or African American</title>
                  <measurement_list>
                    <measurement group_id="B1" value="21"/>
                    <measurement group_id="B2" value="16"/>
                    <measurement group_id="B3" value="37"/>
                  </measurement_list>
                </category>
                <category>
                  <title>White</title>
                  <measurement_list>
                    <measurement group_id="B1" value="263"/>
                    <measurement group_id="B2" value="276"/>
                    <measurement group_id="B3" value="539"/>
                  </measurement_list>
                </category>
                <category>
                  <title>More than one race</title>
                  <measurement_list>
                    <measurement group_id="B1" value="31"/>
                    <measurement group_id="B2" value="32"/>
                    <measurement group_id="B3" value="63"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Unknown or Not Reported</title>
                  <measurement_list>
                    <measurement group_id="B1" value="15"/>
                    <measurement group_id="B2" value="11"/>
                    <measurement group_id="B3" value="26"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Region of Enrollment</title>
          <units>participants</units>
          <param>Number</param>
          <class_list>
            <class>
              <title>United States</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="414"/>
                    <measurement group_id="B2" value="429"/>
                    <measurement group_id="B3" value="843"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </measure_list>
    </baseline>

    <outcome_list>
      <outcome>
        <type>Primary</type>
        <title>Change in Past 6 Month Non-Medical Use of Prescription Stimulant Medication Frequency</title>
        <description>Assesses frequency of non-medical use of prescription stimulant medications. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Change in past 6 month number of days of nonmedical prescription stimulant use.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Past 6 Month Non-Medical Use of Prescription Stimulant Medication Frequency</title>
          <description>Assesses frequency of non-medical use of prescription stimulant medications. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Change in past 6 month number of days of nonmedical prescription stimulant use.</population>
          <units>Usage days</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="336"/>
                <count group_id="O2" value="361"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>6 Month Follow-up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="336"/>
                    <count group_id="O2" value="361"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.04" spread="5.72"/>
                    <measurement group_id="O2" value="-1.72" spread="6.88"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>12 Month Follow-up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="316"/>
                    <count group_id="O2" value="348"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.03" spread="7.91"/>
                    <measurement group_id="O2" value="-.38" spread="11.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Changes from Baseline to 6 Month Follow-up Outcomes reported in this section.</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.03</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.235</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.446</ci_lower_limit>
            <ci_upper_limit>-.023</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Changes from Baseline to 12 Month Follow-up reported in this section.</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.164</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.149</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.360</ci_lower_limit>
            <ci_upper_limit>.061</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Change in Past 6 Month Medical Misuse of Prescription Stimulant Medication</title>
        <description>Assesses past 6 month medical misuse of prescription stimulant medication. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>These analyses were limited to individuals who reported a diagnosis of ADHD (n=62).</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Past 6 Month Medical Misuse of Prescription Stimulant Medication</title>
          <description>Assesses past 6 month medical misuse of prescription stimulant medication. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>These analyses were limited to individuals who reported a diagnosis of ADHD (n=62).</population>
          <units>Usage days</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="27"/>
                <count group_id="O2" value="35"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>6 Month Follow-up</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.30" spread=".72"/>
                    <measurement group_id="O2" value="-.03" spread=".62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>12 Month Follow-up</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.19" spread=".74"/>
                    <measurement group_id="O2" value="-.07" spread=".66"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Medical Misuse of Prescription Stimulant Medication Among those with ADHD Diagnosis from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.603</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.24</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-1.120</ci_lower_limit>
            <ci_upper_limit>.650</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Medical Misuse of Prescription Stimulant Medication Among those with ADHD Diagnosis from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.465</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.336</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-1.238</ci_lower_limit>
            <ci_upper_limit>.566</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Change in Tobacco, Alcohol, Prescription Medications, and Substance Use/Misuse Brief Screen/Assessment Tool (TAPS Tool)</title>
        <description>Assesses problematic use of tobacco, alcohol, prescription, and illicit drugs over the past year and 3 months. Response options included: 0= Never, 1= Less than Monthly, 2= Monthly, 3= Weekly, 4= Daily or Almost Daily. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Tobacco, Alcohol, Prescription Medications, and Substance Use/Misuse Brief Screen/Assessment Tool (TAPS Tool)</title>
          <description>Assesses problematic use of tobacco, alcohol, prescription, and illicit drugs over the past year and 3 months. Response options included: 0= Never, 1= Less than Monthly, 2= Monthly, 3= Weekly, 4= Daily or Almost Daily. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="333"/>
                <count group_id="O2" value="359"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in Past 12 Month Tobacco Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="333"/>
                    <count group_id="O2" value="359"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.03" spread="1.22"/>
                    <measurement group_id="O2" value=".06" spread=".98"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 12 Month Tobacco Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="314"/>
                    <count group_id="O2" value="349"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.15" spread="1.35"/>
                    <measurement group_id="O2" value="0.15" spread="1.18"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 12 Month Alcohol Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="333"/>
                    <count group_id="O2" value="357"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.12" spread=".90"/>
                    <measurement group_id="O2" value="-.02" spread=".83"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 12 Month Alcohol Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="314"/>
                    <count group_id="O2" value="349"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.09" spread=".89"/>
                    <measurement group_id="O2" value="-.1" spread=".93"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 12 Month Other Drug Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="333"/>
                    <count group_id="O2" value="359"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.16" spread="1.14"/>
                    <measurement group_id="O2" value="-.18" spread="1.08"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 12 Month Other Drug Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="314"/>
                    <count group_id="O2" value="349"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.17" spread="1.25"/>
                    <measurement group_id="O2" value="-.22" spread="1.22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 12 Month Nonmedical Prescription Drug Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="333"/>
                    <count group_id="O2" value="359"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.26" spread=".87"/>
                    <measurement group_id="O2" value="-.24" spread=".91"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 12 Month Nonmedical Prescription Drug Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="314"/>
                    <count group_id="O2" value="349"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.3" spread=".97"/>
                    <measurement group_id="O2" value="-.28" spread=".92"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Tobacco Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="332"/>
                    <count group_id="O2" value="359"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.04" spread=".59"/>
                    <measurement group_id="O2" value="0" spread=".53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Tobacco Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="314"/>
                    <count group_id="O2" value="349"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.05" spread=".61"/>
                    <measurement group_id="O2" value=".01" spread=".56"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Alcohol Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="314"/>
                    <count group_id="O2" value="333"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.05" spread=".78"/>
                    <measurement group_id="O2" value="-.1" spread=".80"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Alcohol Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="291"/>
                    <count group_id="O2" value="315"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.90" spread=".81"/>
                    <measurement group_id="O2" value="-.19" spread=".92"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Marijuana Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="333"/>
                    <count group_id="O2" value="359"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.12" spread=".76"/>
                    <measurement group_id="O2" value="-.04" spread=".77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Marijuana Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="314"/>
                    <count group_id="O2" value="349"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.06" spread=".80"/>
                    <measurement group_id="O2" value="-.09" spread=".87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Stimulant Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="333"/>
                    <count group_id="O2" value="359"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.02" spread=".58"/>
                    <measurement group_id="O2" value="-.08" spread=".61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Stimulant Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="313"/>
                    <count group_id="O2" value="349"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.09" spread=".66"/>
                    <measurement group_id="O2" value="-.11" spread=".70"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Heroin Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="333"/>
                    <count group_id="O2" value="359"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".01" spread=".26"/>
                    <measurement group_id="O2" value=".01" spread=".15"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Heroin Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="313"/>
                    <count group_id="O2" value="349"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".01" spread=".28"/>
                    <measurement group_id="O2" value="-.01" spread=".15"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Nonmedical Prescription Drug Use at 6 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="333"/>
                    <count group_id="O2" value="359"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-.01" spread=".26"/>
                    <measurement group_id="O2" value="-.04" spread=".35"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in Past 3 Month Nonmedical Prescription Drug Use at 12 Month Followup</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="314"/>
                    <count group_id="O2" value="349"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".04" spread=".41"/>
                    <measurement group_id="O2" value="-.03" spread=".36"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 12 Month Tobacco Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.486</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.059</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.227</ci_lower_limit>
            <ci_upper_limit>.108</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 12 Month Tobacco Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.942</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.006</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.160</ci_lower_limit>
            <ci_upper_limit>.172</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 12 Month Alcohol Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.552</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.042</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.180</ci_lower_limit>
            <ci_upper_limit>.097</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 12 Month Alcohol Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.608</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.037</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.104</ci_lower_limit>
            <ci_upper_limit>.177</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 12 Month Other Drug Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.840</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.015</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.130</ci_lower_limit>
            <ci_upper_limit>.160</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 12 Month Other Drug Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.927</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.007</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.142</ci_lower_limit>
            <ci_upper_limit>.155</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 12 Month Nonmedical Prescription Drug Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.932</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.010</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.244</ci_lower_limit>
            <ci_upper_limit>.223</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 12 Month Nonmedical Prescription Drug Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.648</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.057</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.300</ci_lower_limit>
            <ci_upper_limit>0.187</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Tobacco Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.702</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.059</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.363</ci_lower_limit>
            <ci_upper_limit>.245</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Tobacco Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.524</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.100</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.408</ci_lower_limit>
            <ci_upper_limit>.208</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Alcohol Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.913</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.008</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.137</ci_lower_limit>
            <ci_upper_limit>.153</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Alcohol Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.676</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regresision</method_desc>
            <param_type>Slope</param_type>
            <param_value>.032</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.117</ci_lower_limit>
            <ci_upper_limit>.181</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Marijuana Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.712</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.035</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.223</ci_lower_limit>
            <ci_upper_limit>.152</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Marijuana Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.956</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.005</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.186</ci_lower_limit>
            <ci_upper_limit>0.197</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Stimulant Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.446</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.149</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.234</ci_lower_limit>
            <ci_upper_limit>.531</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Stimulant Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.793</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.055</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.353</ci_lower_limit>
            <ci_upper_limit>.462</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Heroin Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.999</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-.001</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-2.005</ci_lower_limit>
            <ci_upper_limit>2.003</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Heroin Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.397</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.999</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-1.312</ci_lower_limit>
            <ci_upper_limit>3.310</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Nonmedical Prescription Drug Use from Baseline to 6 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>.303</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.465</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.419</ci_lower_limit>
            <ci_upper_limit>1.349</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in Past 3 Month Nonmedical Prescription Drug Use from Baseline to 12 Month Followup</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>&lt;.05</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>.939</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>.128</ci_lower_limit>
            <ci_upper_limit>1.751</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Change in Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) - Stimulants Only</title>
        <description>Measures past 3 month non-medical use of prescription stimulants and associated negative consequences. Items were summed to create a scale summary score where higher values indicated more problematic use in the past 3 months (min=0, max=40). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) - Stimulants Only</title>
          <description>Measures past 3 month non-medical use of prescription stimulants and associated negative consequences. Items were summed to create a scale summary score where higher values indicated more problematic use in the past 3 months (min=0, max=40). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="330"/>
                <count group_id="O2" value="356"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in ASSIST score at 6 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="330"/>
                    <count group_id="O2" value="356"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.420" spread="4.59"/>
                    <measurement group_id="O2" value="-1.08" spread="5.02"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in ASSIST score at 12 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="312"/>
                    <count group_id="O2" value="344"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.26" spread="5.35"/>
                    <measurement group_id="O2" value="-1.19" spread="5.24"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in ASSIST Score over time: 6 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.151</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative binomial regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.1816</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.4295</ci_lower_limit>
            <ci_upper_limit>0.0663</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Changes in ASSIST scores at 12 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.642</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0601</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.3133</ci_lower_limit>
            <ci_upper_limit>0.1931</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Change in Past 6 Month Prescription Stimulant Use Consequence Questionnaire</title>
        <description>Assesses negative consequences associated with prescription stimulant misuse over the previous 6 months. A score of &quot;0&quot; indicates that a given consequence did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=19). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>6 and 12 month follow-up</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Past 6 Month Prescription Stimulant Use Consequence Questionnaire</title>
          <description>Assesses negative consequences associated with prescription stimulant misuse over the previous 6 months. A score of &quot;0&quot; indicates that a given consequence did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=19). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="329"/>
                <count group_id="O2" value="357"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in consequence score at 6 months</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="329"/>
                    <count group_id="O2" value="357"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.27" spread="3.8"/>
                    <measurement group_id="O2" value="-1.07" spread="3.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in consequence score at 12 months</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="308"/>
                    <count group_id="O2" value="342"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.92" spread="4.15"/>
                    <measurement group_id="O2" value="-1.11" spread="4.16"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in consequence score at 6 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.074</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.2177</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.4566</ci_lower_limit>
            <ci_upper_limit>0.0213</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in consequence score at 12 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.351</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.1165</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.3612</ci_lower_limit>
            <ci_upper_limit>0.1282</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Change in Peak Quantity of Alcohol Consumed in Past Month</title>
        <description>Assesses quantity in standard drinks of peak drinking episode of alcohol consumption over the past month. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Peak Quantity of Alcohol Consumed in Past Month</title>
          <description>Assesses quantity in standard drinks of peak drinking episode of alcohol consumption over the past month. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>standard drinks</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="322"/>
                <count group_id="O2" value="357"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in peak alcohol standard drink total at 6 months</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="322"/>
                    <count group_id="O2" value="357"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.94" spread="3.71"/>
                    <measurement group_id="O2" value="-1.23" spread="4.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in peak standard drink total at 12 months</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="310"/>
                    <count group_id="O2" value="345"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.26" spread="3.82"/>
                    <measurement group_id="O2" value="-1.48" spread="4.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in peak alcohol quantity at 6 months (reported by number of standard drinks)</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.255</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0440</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.032</ci_lower_limit>
            <ci_upper_limit>0.1197</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in peak alcohol quantity (reported in standard drinks) at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.428</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0315</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.0463</ci_lower_limit>
            <ci_upper_limit>0.1092</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Change in Past 6 Month Daily Drinking Questionnaire</title>
        <description>Assesses typical alcohol consumption over the course of a typical week. Responses for number of drinks consumed each day of a typical week were summed to create a summary score of total number of drinks consumed over a typical week. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Past 6 Month Daily Drinking Questionnaire</title>
          <description>Assesses typical alcohol consumption over the course of a typical week. Responses for number of drinks consumed each day of a typical week were summed to create a summary score of total number of drinks consumed over a typical week. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Number of drinks</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="312"/>
                <count group_id="O2" value="350"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in DDQ score at 6 months</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="312"/>
                    <count group_id="O2" value="350"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.09" spread="6.92"/>
                    <measurement group_id="O2" value="-2.11" spread="7.22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in DDQ score at 12 months</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="303"/>
                    <count group_id="O2" value="337"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-2.81" spread="8.60"/>
                    <measurement group_id="O2" value="-2.07" spread="8.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in DDQ score at 6 months</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.966</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0021</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.0936</ci_lower_limit>
            <ci_upper_limit>0.0978</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in DDQ score at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.265</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0559</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1542</ci_lower_limit>
            <ci_upper_limit>0.0424</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Change in Past 6 Month Rutgers Alcohol Problem Index</title>
        <description>Measures negative alcohol-related consequences experienced over the past 6 months. A score of &quot;0&quot; indicates that a given consequence did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=26). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Past 6 Month Rutgers Alcohol Problem Index</title>
          <description>Measures negative alcohol-related consequences experienced over the past 6 months. A score of &quot;0&quot; indicates that a given consequence did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=26). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="321"/>
                <count group_id="O2" value="356"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in RAPI score at 6 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="321"/>
                    <count group_id="O2" value="356"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.66" spread="5.06"/>
                    <measurement group_id="O2" value="-1.42" spread="4.44"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in RAPI score at 12 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="304"/>
                    <count group_id="O2" value="342"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.47" spread="5.71"/>
                    <measurement group_id="O2" value="-1.21" spread="4.94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in RAPI count at 6 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.868</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0128</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1633</ci_lower_limit>
            <ci_upper_limit>0.1378</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in RAPI count at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.573</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0445</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1993</ci_lower_limit>
            <ci_upper_limit>0.1102</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Change in Past Year, 6 Month, and 30 Day Marijuana Use Frequency</title>
        <description>Items measure typical frequency of marijuana use and number of days used in the past year, 6 months, and 30 days. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Past Year, 6 Month, and 30 Day Marijuana Use Frequency</title>
          <description>Items measure typical frequency of marijuana use and number of days used in the past year, 6 months, and 30 days. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Usage days</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="320"/>
                <count group_id="O2" value="353"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in past year marijuana use at 6 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="320"/>
                    <count group_id="O2" value="353"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.22" spread="72.74"/>
                    <measurement group_id="O2" value="3.60" spread="66.67"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in past year marijuana use at 12 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="306"/>
                    <count group_id="O2" value="342"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.90" spread="84.00"/>
                    <measurement group_id="O2" value="0.35" spread="87.60"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in past 6 month marijuana use at 6 month follow-up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="320"/>
                    <count group_id="O2" value="353"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.49" spread="36.58"/>
                    <measurement group_id="O2" value="1.69" spread="34.04"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in past 6 month marijuana use at 12 month follow-up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="306"/>
                    <count group_id="O2" value="342"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.22" spread="41.52"/>
                    <measurement group_id="O2" value="-0.57" spread="42.00"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in past month marijuana use at 6 month follow-up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="319"/>
                    <count group_id="O2" value="353"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.07" spread="7.22"/>
                    <measurement group_id="O2" value="0.00" spread="7.33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in past month marijuana use at 12 month follow-up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="305"/>
                    <count group_id="O2" value="342"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.53" spread="8.56"/>
                    <measurement group_id="O2" value="-0.39" spread="8.47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in past 12 month marijuana use at 6 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.266</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0899</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.2484</ci_lower_limit>
            <ci_upper_limit>0.0685</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Past 12 month marijuana use at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.816</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0197</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1859</ci_lower_limit>
            <ci_upper_limit>0.1465</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in past 6 month marijuana use at 6 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.209</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.1031</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.2639</ci_lower_limit>
            <ci_upper_limit>0.0577</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in past 6 month marijuana use at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.944</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0060</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1729</ci_lower_limit>
            <ci_upper_limit>0.1608</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in past month marijuana use at 6 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.654</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0391</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.2102</ci_lower_limit>
            <ci_upper_limit>0.1320</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in past month marijuana use at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.481</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0646</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.2444</ci_lower_limit>
            <ci_upper_limit>0.1152</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Change in Past 6 Month Rutgers Marijuana Problem Index</title>
        <description>Measures negative marijuana-related consequences experienced over the past 6 months. A score of &quot;0&quot; indicates that a given consequence did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=26). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Past 6 Month Rutgers Marijuana Problem Index</title>
          <description>Measures negative marijuana-related consequences experienced over the past 6 months. A score of &quot;0&quot; indicates that a given consequence did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=26). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="316"/>
                <count group_id="O2" value="347"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in RMPI count at 6 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="316"/>
                    <count group_id="O2" value="347"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.81" spread="6.13"/>
                    <measurement group_id="O2" value="-0.66" spread="5.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in RMPI count at 12 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="304"/>
                    <count group_id="O2" value="339"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.81" spread="6.00"/>
                    <measurement group_id="O2" value="-1.01" spread="6.20"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in RMPI count at 6 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.487</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0411</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1569</ci_lower_limit>
            <ci_upper_limit>0.0747</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in RMPI count at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.772</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0177</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1021</ci_lower_limit>
            <ci_upper_limit>0.1375</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Other Pre-specified</type>
        <title>Change in Past 6 Month Relapse Prevention/Protective Behaviors Scale</title>
        <description>Measures the use of relapse prevention strategies and protective behaviors related to stimulant medication misuse. A score of &quot;0&quot; indicates that a given strategy did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique relapse prevention/protective behavior strategies that occurred in the past 6 months (min=0, max=28). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Past 6 Month Relapse Prevention/Protective Behaviors Scale</title>
          <description>Measures the use of relapse prevention strategies and protective behaviors related to stimulant medication misuse. A score of &quot;0&quot; indicates that a given strategy did not occur and a score of &quot;1&quot; indicates that it did occur. Items were summed to create a scale summary score of overall number of unique relapse prevention/protective behavior strategies that occurred in the past 6 months (min=0, max=28). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="316"/>
                <count group_id="O2" value="347"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in PBS count at 6 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="316"/>
                    <count group_id="O2" value="347"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.32" spread="6.03"/>
                    <measurement group_id="O2" value="-1.40" spread="6.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in PBS count at 12 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="302"/>
                    <count group_id="O2" value="337"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.77" spread="7.36"/>
                    <measurement group_id="O2" value="-1.30" spread="6.80"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in PBS count at 6 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.075</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.1285</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.0131</ci_lower_limit>
            <ci_upper_limit>0.2702</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in PBS count at 12 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.207</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0936</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.0517</ci_lower_limit>
            <ci_upper_limit>0.2388</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Other Pre-specified</type>
        <title>Change in Past Year Prescription Stimulant Norms Rating Form</title>
        <description>Assesses the perceived percentage of students who have misused prescription stimulant medication in the past year. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Past Year Prescription Stimulant Norms Rating Form</title>
          <description>Assesses the perceived percentage of students who have misused prescription stimulant medication in the past year. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Percentage</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="336"/>
                <count group_id="O2" value="360"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in perceived norm (in perceived past year days of use) at 6 month</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="336"/>
                    <count group_id="O2" value="360"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-9.29" spread="19.37"/>
                    <measurement group_id="O2" value="-4.11" spread="20.44"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in perceived norm (in perceived past year days of use) at 12 month</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="319"/>
                    <count group_id="O2" value="348"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-11.10" spread="20.99"/>
                    <measurement group_id="O2" value="-6.36" spread="18.50"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in perceived norm (in perceived days of use in past year) at 6 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>&lt;0.001</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.1604</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.2525</ci_lower_limit>
            <ci_upper_limit>-0.0683</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in perceived norm (perceived number of days of use in past year) at 12 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>&lt;.003</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.1441</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.2404</ci_lower_limit>
            <ci_upper_limit>-0.0478</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Other Pre-specified</type>
        <title>Change in Current Semester/Quarter Motivated Strategies for Learning Questionnaire (MSLQ)</title>
        <description>A 19-item abbreviated version of the Motivated Strategies for Learning Questionnaire was used to measures the use of different types of learning strategies and academic motivations during the current semester/quarter. Response options ranged from 1=Not at all true of me to 7=Very true of me. Mean scale scores were computed and change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Current Semester/Quarter Motivated Strategies for Learning Questionnaire (MSLQ)</title>
          <description>A 19-item abbreviated version of the Motivated Strategies for Learning Questionnaire was used to measures the use of different types of learning strategies and academic motivations during the current semester/quarter. Response options ranged from 1=Not at all true of me to 7=Very true of me. Mean scale scores were computed and change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="312"/>
                <count group_id="O2" value="351"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in MSLQ score at 6 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="312"/>
                    <count group_id="O2" value="351"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.10" spread="1.07"/>
                    <measurement group_id="O2" value="-0.08" spread="0.95"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in MSLQ score at 12 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="295"/>
                    <count group_id="O2" value="338"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-0.01" spread="1.06"/>
                    <measurement group_id="O2" value="-0.1" spread="1.09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in MSLQ score at 6 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.743</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0157</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1096</ci_lower_limit>
            <ci_upper_limit>0.0782</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in MSLQ score at 12 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.784</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0133</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.0816</ci_lower_limit>
            <ci_upper_limit>0.1081</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Other Pre-specified</type>
        <title>Change in Cumulative and Last Semester/Quarter Grade Point Average (GPA)</title>
        <description>Participants report their cumulative and previous semester/quarter GPA. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>6 and 12 month follow-up</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Cumulative and Last Semester/Quarter Grade Point Average (GPA)</title>
          <description>Participants report their cumulative and previous semester/quarter GPA. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="335"/>
                <count group_id="O2" value="366"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in cumulative GPA at 6 month follow up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="335"/>
                    <count group_id="O2" value="366"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.01" spread="0.21"/>
                    <measurement group_id="O2" value="-0.002" spread="0.20"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in cumulative GPA at 12 month follow-up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="322"/>
                    <count group_id="O2" value="354"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.02" spread="0.26"/>
                    <measurement group_id="O2" value="0.03" spread="0.24"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in last term GPA at 6 month follow-up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="335"/>
                    <count group_id="O2" value="364"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.05" spread="0.45"/>
                    <measurement group_id="O2" value="0.01" spread="0.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in last term GPA at 12 month follow-up</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="321"/>
                    <count group_id="O2" value="352"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.05" spread="0.50"/>
                    <measurement group_id="O2" value="0.24" spread="0.48"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in cumulative grade point average at 6 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.914</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0061</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1161</ci_lower_limit>
            <ci_upper_limit>0.104</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in cumulative grade point average at 12 month follow up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.871</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>General Linear Model</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0092</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1202</ci_lower_limit>
            <ci_upper_limit>0.1018</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in last term GPA at 6 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.957</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0030</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1063</ci_lower_limit>
            <ci_upper_limit>0.1124</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in last term GPA at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.992</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Poisson regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0006</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1098</ci_lower_limit>
            <ci_upper_limit>0.1109</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Change in Frequency of Past Month Alcohol Consumption</title>
        <description>Assesses frequency (days) of alcohol consumption over the past month (min=0, max=31). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Frequency of Past Month Alcohol Consumption</title>
          <description>Assesses frequency (days) of alcohol consumption over the past month (min=0, max=31). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>Usage days</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="322"/>
                <count group_id="O2" value="357"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in past month frequency alcohol at 6 months</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.21" spread="4.94"/>
                    <measurement group_id="O2" value="-1.61" spread="5.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in past month alcohol frequency at 12 months</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.04" spread="5.63"/>
                    <measurement group_id="O2" value="-1.30" spread="6.36"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in past month alcohol frequency at 6 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.447</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.039</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-.0615</ci_lower_limit>
            <ci_upper_limit>0.1395</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in past month alcohol frequency at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.443</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0398</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.0619</ci_lower_limit>
            <ci_upper_limit>0.1414</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Change in Typical Quantity in Standard Drinks Consumed on a Typical Occasion in the Past Month</title>
        <description>Assesses typical drinking quantity in standard drinks of alcohol consumed during a typical drinking occasion over the past month. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
        <time_frame>Baseline and 6 months, Baseline and 12 months</time_frame>
        <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
        <group_list>
          <group group_id="O1">
            <title>Web-Based PFI</title>
            <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
          </group>
          <group group_id="O2">
            <title>Assessment Only</title>
            <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
          </group>
        </group_list>
        <measure>
          <title>Change in Typical Quantity in Standard Drinks Consumed on a Typical Occasion in the Past Month</title>
          <description>Assesses typical drinking quantity in standard drinks of alcohol consumed during a typical drinking occasion over the past month. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).</description>
          <population>Difference in number analyzed by condition are due to differences in follow-up participation rates and/or items skipped by participants.</population>
          <units>standard drinks</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="322"/>
                <count group_id="O2" value="357"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Change in past month typical quantity at 6 months</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.47" spread="3.82"/>
                    <measurement group_id="O2" value="-1.40" spread="3.89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Change in past month typical quantity at 12 months</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="-1.90" spread="4.16"/>
                    <measurement group_id="O2" value="-1.57" spread="4.42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in past month alcohol typical quantity at 6 months</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.997</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>0.0002</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1066</ci_lower_limit>
            <ci_upper_limit>0.1070</ci_upper_limit>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Change in past month typical alcohol quantity at 12 month follow-up</groups_desc>
            <non_inferiority_type>Other</non_inferiority_type>
            <non_inferiority_desc>General Linear Model</non_inferiority_desc>
            <p_value>0.808</p_value>
            <method>Mixed Models Analysis</method>
            <method_desc>Negative Binomial Regression</method_desc>
            <param_type>Slope</param_type>
            <param_value>-0.0136</param_value>
            <ci_percent>95</ci_percent>
            <ci_n_sides>2-Sided</ci_n_sides>
            <ci_lower_limit>-0.1236</ci_lower_limit>
            <ci_upper_limit>0.0963</ci_upper_limit>
          </analysis>
        </analysis_list>
      </outcome>
    </outcome_list>

    <reported_events>
      <time_frame>1 year</time_frame>
      <group_list>
        <group group_id="E1">
          <title>Web-Based PFI</title>
          <description>Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.&#xD;
Web-based PFI: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.</description>
        </group>
        <group group_id="E2">
          <title>Assessment Only</title>
          <description>The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.&#xD;
Assessment Only: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.</description>
        </group>
      </group_list>
      <serious_events>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, all-cause mortality</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="414"/>
                <counts group_id="E2" subjects_affected="0" subjects_at_risk="429"/>
              </event>
              <event>
                <sub_title>Total, serious adverse events</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="414"/>
                <counts group_id="E2" subjects_affected="0" subjects_at_risk="429"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </serious_events>
      <other_events>
        <frequency_threshold>0</frequency_threshold>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, other adverse events</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="414"/>
                <counts group_id="E2" subjects_affected="0" subjects_at_risk="429"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </other_events>
    </reported_events>

    <certain_agreements>
      <pi_employee>Principal Investigators are NOT employed by the organization sponsoring the study.</pi_employee>
      <restrictive_agreement>There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed. </restrictive_agreement>
    </certain_agreements>
    <point_of_contact>
      <name_or_title>Jason Kilmer, Ph.D.</name_or_title>
      <organization>University of Washington</organization>
      <phone>206-685-4512</phone>
      <email>jkilmer@uw.edu</email>
    </point_of_contact>
  </clinical_results>
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03037476
org study id: STUDY00001782
secondary id: 3U01DA040219-04S1
nct id: NCT03037476
lead sponsor: 
collaborator: 
has dmc: Yes
is fda regulated drug: No
is fda regulated device: No
This research will adapt an evidence based intervention for alcohol and other drugs and
      evaluate its efficacy on Prescription Stimulant Medication (PSM) misuse in a web-based format
      for use with college students who have misused PSMs.
This project proposes to evaluate the efficacy of Screening and Brief Interventions (SBIs)
      for reducing college students' PSM misuse through two different routes of screening and
      intervention across 9 colleges and universities spanning the United States. The research will
      consist of studies designed to 1) conduct focus groups to refine feedback materials (Study
      1); 2) Conduct screening through the Registrar's student lists and implement a randomized
      controlled trial (RCT) of a web-based PSM intervention at all sites (Study 2); and 3)
      Evaluate the impact of the COVID-19 pandemic using the Study 2 sample on non-medical use of
      prescription stimulants, prescription opiates, alcohol use, marijuana use, and other
      substances during the COVID-19 pandemic, and understand motives, access, mental health
      impacts, and college student and young adult experiences during this unprecedented 12 months.

      Study 1 consists of conducting up to 5 focus groups of 8-12 people to elicit feedback
      regarding the Personalized Feedback Tool and make refinements prior to carrying out Study 2.

      In Study 2, students from 9 college campuses are screened for past year PSM misuse. Those
      meeting study criteria are invited to complete a web-based baseline survey and are randomized
      to either receive the web-based personalized feedback intervention (PFI) or to assessment
      only control. Participants complete follow-up assessments at 6 and 12 months post-baseline to
      evaluate intervention efficacy. The investigators hypothesize that participants who receive
      the PFI will reduce PSM misuse assessed at 6 and 12 month follow-ups. The investigators
      further expect reductions in perceived benefits of PSM and perceived descriptive norms for
      PSM, and increases in use of alternative behaviors to support academic success, and expect
      these changes will mediate impacts on PSM use at follow-ups. Secondary effects of the
      intervention on alcohol and marijuana use are also anticipated, and these reductions are
      expected to partially mediate PSM outcomes. Finally, PSM motives and demographics as
      potential moderators of intervention efficacy will also be explored.

      Lastly, in February of 2021, we received approval to modify the aims for Study 3 to evaluate
      the impact of the COVID-19 pandemic using the Study 2 sample. In an already consented,
      recruited, and well-characterized sample of high-risk young adults reporting poly-substance
      use (Study 2 participants, n=843), Study 3 aimed to describe changes in non-medical use of
      prescription stimulants, prescription opiates, alcohol use, marijuana use, and other
      substances during the COVID-19 pandemic, and understand motives, access, mental health
      impacts, and college student and young adult experiences during this unprecedented 12 months.
      Specifically, we intend to evaluate changes pre- and post-pandemic in non-medical use of PSM,
      non-medical use of prescription opioid medications (POM), alcohol use, and marijuana use, as
      well as mood utilizing Study 2 baseline and follow-up data, controlling for intervention
      condition and time since last assessment. We also will evaluate student status and living
      arrangement as moderators. The investigators hypothesize: (1) Young adults will report less
      PSM and less POM during the pandemic compared to pre-pandemic assessments, in part due to
      reduced ease of access and a change in motives for use; (2) Given previous findings that
      academic motives were 8 of the 9 most frequently endorsed reasons for PSM, and given
      perceptions that a move to virtual learning has been less academically challenging, we
      hypothesize that academic motives for PSM will decrease significantly during the pandemic
      compared to pre-pandemic; (3) Those no longer in school will report less PSM and less POM
      during the pandemic compared to pre-pandemic. (4) Those living at home will have decreased
      alcohol and marijuana use compared to pre-pandemic. Among those reporting current student
      status at the time of the new survey, we will be able to evaluate changes in motives for use,
      access, and academic pressure from baseline to present.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Single (Participant)
measure: Change in Past 6 Month Non-Medical Use of Prescription Stimulant Medication Frequency
time frame: Baseline and 6 months, Baseline and 12 months
description: Assesses frequency of non-medical use of prescription stimulant medications. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Past 6 Month Medical Misuse of Prescription Stimulant Medication
time frame: Baseline and 6 months, Baseline and 12 months
description: Assesses past 6 month medical misuse of prescription stimulant medication. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Tobacco, Alcohol, Prescription Medications, and Substance Use/Misuse Brief Screen/Assessment Tool (TAPS Tool)
time frame: Baseline and 6 months, Baseline and 12 months
description: Assesses problematic use of tobacco, alcohol, prescription, and illicit drugs over the past year and 3 months. Response options included: 0= Never, 1= Less than Monthly, 2= Monthly, 3= Weekly, 4= Daily or Almost Daily. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) - Stimulants Only
time frame: Baseline and 6 months, Baseline and 12 months
description: Measures past 3 month non-medical use of prescription stimulants and associated negative consequences. Items were summed to create a scale summary score where higher values indicated more problematic use in the past 3 months (min=0, max=40). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Past 6 Month Prescription Stimulant Use Consequence Questionnaire
time frame: 6 and 12 month follow-up
description: Assesses negative consequences associated with prescription stimulant misuse over the previous 6 months. A score of "0" indicates that a given consequence did not occur and a score of "1" indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=19). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Peak Quantity of Alcohol Consumed in Past Month
time frame: Baseline and 6 months, Baseline and 12 months
description: Assesses quantity in standard drinks of peak drinking episode of alcohol consumption over the past month. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Past 6 Month Daily Drinking Questionnaire
time frame: Baseline and 6 months, Baseline and 12 months
description: Assesses typical alcohol consumption over the course of a typical week. Responses for number of drinks consumed each day of a typical week were summed to create a summary score of total number of drinks consumed over a typical week. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Past 6 Month Rutgers Alcohol Problem Index
time frame: Baseline and 6 months, Baseline and 12 months
description: Measures negative alcohol-related consequences experienced over the past 6 months. A score of "0" indicates that a given consequence did not occur and a score of "1" indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=26). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Past Year, 6 Month, and 30 Day Marijuana Use Frequency
time frame: Baseline and 6 months, Baseline and 12 months
description: Items measure typical frequency of marijuana use and number of days used in the past year, 6 months, and 30 days. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Past 6 Month Rutgers Marijuana Problem Index
time frame: Baseline and 6 months, Baseline and 12 months
description: Measures negative marijuana-related consequences experienced over the past 6 months. A score of "0" indicates that a given consequence did not occur and a score of "1" indicates that it did occur. Items were summed to create a scale summary score of overall number of unique consequences that occurred in the past 6 months (min=0, max=26). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Frequency of Past Month Alcohol Consumption
time frame: Baseline and 6 months, Baseline and 12 months
description: Assesses frequency (days) of alcohol consumption over the past month (min=0, max=31). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Typical Quantity in Standard Drinks Consumed on a Typical Occasion in the Past Month
time frame: Baseline and 6 months, Baseline and 12 months
description: Assesses typical drinking quantity in standard drinks of alcohol consumed during a typical drinking occasion over the past month. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Past 6 Month Relapse Prevention/Protective Behaviors Scale
time frame: Baseline and 6 months, Baseline and 12 months
description: Measures the use of relapse prevention strategies and protective behaviors related to stimulant medication misuse. A score of "0" indicates that a given strategy did not occur and a score of "1" indicates that it did occur. Items were summed to create a scale summary score of overall number of unique relapse prevention/protective behavior strategies that occurred in the past 6 months (min=0, max=28). Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Past Year Prescription Stimulant Norms Rating Form
time frame: Baseline and 6 months, Baseline and 12 months
description: Assesses the perceived percentage of students who have misused prescription stimulant medication in the past year. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Current Semester/Quarter Motivated Strategies for Learning Questionnaire (MSLQ)
time frame: Baseline and 6 months, Baseline and 12 months
description: A 19-item abbreviated version of the Motivated Strategies for Learning Questionnaire was used to measures the use of different types of learning strategies and academic motivations during the current semester/quarter. Response options ranged from 1=Not at all true of me to 7=Very true of me. Mean scale scores were computed and change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
measure: Change in Cumulative and Last Semester/Quarter Grade Point Average (GPA)
time frame: 6 and 12 month follow-up
description: Participants report their cumulative and previous semester/quarter GPA. Change was calculated from two time points as the value at the later time point minus the value at the earlier time point (e.g., value at 6 months minus value at baseline and the value at 12 months minus the value at baseline).
arm group label: Web-Based PFI
arm group type: Experimental
description: Participants randomized to the web-based PFI in Study 2 receive a 5 component Personalized Feedback Tool. The first component is presented immediately after the baseline survey and a link to each of the remaining 4 components is sent to participants spaced 1 to 2 weeks apart. The PFI components cover: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol. Each component is comprised of personalized feedback presented in text and graphic format, and each component includes links to tips for making changes if and when the participant is contemplating or ready to commit to change. These tips include general relapse prevention strategies, as well as information about the importance of regular class attendance, study habits, and sleep habits for academic success. General educational tips/strategies for time management, as well as tips for initiating behavior change are also included. Each component takes approximately 5-10 minutes to review.
arm group label: Assessment Only
arm group type: Other
description: The Assessment Only group receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6-month follow-up, and 12-month follow-up in Study 2.
intervention type: Behavioral
intervention name: Web-based PFI
description: A web-based 5 component Personalized Feedback Tool covering content on: 1) Stimulants, 2) Marijuana, 3) PSM and unwanted effects, 4) Academics, and 5) Alcohol.
arm group label: Web-Based PFI
intervention type: Behavioral
intervention name: Assessment Only
description: The Assessment Only condition receives assessment on substance use, health behaviors, and academic behaviors at baseline, 6 month follow-up, and 12 month follow-up.
arm group label: Assessment Only
criteria: 
gender: All
minimum age: 18 Years
maximum age: 25 Years
healthy volunteers: Accepts Healthy Volunteers
facility: 
country: United States
responsible party type: Principal Investigator
investigator affiliation: University of Washington
investigator full name: Jason Kilmer
investigator title: Associate Professor, School of Medicine: Psychiatry
mesh term: Substance-Related Disorders
sharing ipd: No
provided document: 
provided document: 
participant flow: 
baseline: 
outcome list: 
reported events: 
certain agreements: 
point of contact: 