<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03005366</url>
  </required_header>
  <id_info>
    <org_study_id>SELECTI-CARFAP</org_study_id>
    <nct_id>NCT03005366</nct_id>
  </id_info>
  <brief_title>Predictive Factors to Effectively Terminate Paroxysmal Atrial Fibrillation by Blocking Atrial Selective Ionic Currents</brief_title>
  <acronym>SELECTCARFAP</acronym>
  <official_title>Randomized Clinical Trial to Study Pharmacological Cardioversion of Paroxysmal Atrial Fibrillation by Vernakalant and Flecainide</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>David Filgueiras-Rama</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Hospital San Carlos, Madrid</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      -  The main objective of this project is to study the efficacy and the mechanistic value of&#xD;
           blocking both atrial specific and atria-preferential dynamics of ionic currents to&#xD;
           terminate paroxysmal atrial fibrillation (AF).&#xD;
&#xD;
        -  The hypothesis is that a drug blocking atrial specific and atria-preferential dynamics&#xD;
           of ionic currents (IK,ACh - acetylcholine sensitive K+ current - and INa - inward sodium&#xD;
           current - , respectively) will be more effective to terminate paroxysmal AF episodes&#xD;
           with fast atrial activation rates, than a classical INa blocker, which will be more&#xD;
           effective to terminate AF episodes with slower activation rates.&#xD;
&#xD;
        -  The investigators will include patients without structural heart disease and&#xD;
           short-lasting AF episodes (&lt;48 h.). Double blind and single center study, in which&#xD;
           patients will be randomly assigned to a cardioversion group using intravenous flecainide&#xD;
           or to an atria-preferential and atrial-specific blockade group using intravenous&#xD;
           vernakalant. Patients will be routinely monitored in the electrophysiology room to&#xD;
           acquire both 12-lead digitized ECG signals and non-invasive body surface potential&#xD;
           mapping. Atrial signals will be extracted from both the multisite body surface and ECG&#xD;
           recordings to obtain temporal and spectral parameters, and measure organization and&#xD;
           atrial rate in both groups. The results obtained in the clinical setting will be studied&#xD;
           in mathematical models to understand their capability to terminate paroxysmal AF. The&#xD;
           project expects to provide consistent, reliable and reproducible parameters that will&#xD;
           assist clinicians to know what type of paroxysmal AF episodes will be more suitable to&#xD;
           effectively terminate, upon administration of drugs with an atrial specific and&#xD;
           atria-preferential profile.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      -  Background: Different research strategies aim at understanding the mechanisms underlying&#xD;
           the maintenance of atrial fibrillation (AF), while preventing ventricular pro-arrhythmia&#xD;
           related to the use of anti-arrhythmic drugs to restore sinus rhythm. Such aims might be&#xD;
           achieved by drugs that effectively terminate reentrant sources identified during AF,&#xD;
           along with an atrial specific and atria-preferential blockade of ionic currents. The&#xD;
           latter may be especially relevant in paroxysmal AF episodes with fast atrial activation&#xD;
           rates, in which INa and IK,ACh are involved in the maintenance of fast atrial reentrant&#xD;
           sources underlying AF.&#xD;
&#xD;
        -  Objective: The main objective of this project is to study the efficacy and the&#xD;
           mechanistic value of blocking both atrial specific and atria-preferential dynamics of&#xD;
           ionic currents to terminate paroxysmal AF.&#xD;
&#xD;
        -  The hypothesis is that a drug blocking atrial specific and atria-preferential dynamics&#xD;
           of ionic currents (IK,ACh and INa, respectively) will be more effective to terminate&#xD;
           paroxysmal AF episodes with fast atrial activation rates, than a classical INa blocker,&#xD;
           which will be more effective to terminate AF episodes with slower activation rates.&#xD;
&#xD;
        -  Design: Double blind and single center study, in which patients will be randomly&#xD;
           assigned to a cardioversion group using intravenous flecainide or to an&#xD;
           atria-preferential and atrial-specific blockade group using intravenous vernakalant.&#xD;
           Patients will be routinely monitored in the electrophysiology room for 90 minutes upon&#xD;
           drug administration to acquire both 12-lead digitized ECG signals and non-invasive body&#xD;
           surface potential mapping. Body surface recordings and conventional ECG signals will be&#xD;
           exported to obtain temporal and spectral parameters of atrial activity during AF, and&#xD;
           measure organization and atrial rate in both groups of patients undergoing&#xD;
           pharmacological cardioversion. The success rate of cardioversion obtained in both groups&#xD;
           will be correlated with the patterns of activation and spectral parameters obtained from&#xD;
           the body surface, which will provide what type of paroxysmal AF episodes are suitable to&#xD;
           terminate upon administration of anti-arrhythmic drugs with an atrial specific and&#xD;
           atria-preferential profile.&#xD;
&#xD;
      Electrical cardioversion will be performed in subjects with unsuccessful pharmacological&#xD;
      cardioversion within the first 24 h. after vernakalant or flecainide administration.&#xD;
&#xD;
      The results obtained in the clinical setting will be studied in realistic mathematical models&#xD;
      to further understand the capability of both drugs to terminate paroxysmal AF.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">January 2017</start_date>
  <completion_date type="Actual">August 2023</completion_date>
  <primary_completion_date type="Actual">June 2023</primary_completion_date>
  <phase>Phase 4</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Electrocardiographic-based spectral parameters of atrial fibrillatory activity (Dominant frequency) associated with successful or unsuccessful cardioversion in both groups of patients.</measure>
    <time_frame>18 months</time_frame>
    <description>The investigators will quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with successful cardioversion in the vernakalant and flecainide groups.&#xD;
The investigators will also quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with successful and unsuccessful cardioversion within the vernakalant or flecainide group.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Cardioversion success (yes/no) in patients with paroxysmal atrial fibrillation episodes lasting &lt; 24 hours or ≥24 hours.</measure>
    <time_frame>18 months</time_frame>
    <description>The investigators will quantify the difference in cardioversion success (yes/no) between episodes lasting &lt; 24 hours or ≥24 hours.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Electrocardiographic-based spectral parameters of atrial fibrillatory activity (Dominant frequency) in patients with episodes lasting &lt; 24 hours or ≥24 hours.</measure>
    <time_frame>18 months</time_frame>
    <description>The investigators will quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with episodes lasting &lt; 24 hours or ≥24 hours.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Spectral parameters of atrial fibrillatory activity (Dominant frequency) recorded by non-invasive body surface potential mapping associated with successful or unsuccessful cardioversion in both groups of patients.</measure>
    <time_frame>24 months</time_frame>
    <description>The investigators will quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with successful cardioversion in the vernakalant and flecainide groups.&#xD;
The investigators will also quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with successful and unsuccessful cardioversion within the vernakalant or flecainide group.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Effects on reentrant-based atrial fibrillation (dominant frequency decrease, rotor meandering) in 2D models of fast and low atrial activation rates under the effect of vernakalant or flecainide.</measure>
    <time_frame>24 months</time_frame>
    <description>The investigators will quantify dominant frequency changes (Hz) and rotor meandering (mm) under the effect of vernakalant or flecainide in 2D computational models.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Atrial Fibrillation Quality of Life questionnaire (AF-QOL).</measure>
    <time_frame>24 months</time_frame>
    <description>The Investigators will quantify the effects of atrial fibrillation on patients´ quality of life base on of the Atrial Fibrillation Quality of Life questionnaire (AF-QOL).</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Patient's perception during cardioversion. The investigators will used a custom-designed five-question questionnaire as follows:</measure>
    <time_frame>24 months</time_frame>
    <description>i) Do you recall something from the cardioversion attempt? yes/no. ii) If (1) is yes, was it uncomfortable? yes/no. iii) Did you feel any pain during the cardioversion attempt? yes/no. iv) Please, provide an score from '0' to '10' to evaluate your general perception of the cardioversion attempt.&#xD;
v) If necessary, would you undergo another cardioversion attempt using the same strategy? yes/no.</description>
  </other_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">50</enrollment>
  <condition>Paroxysmal Atrial Fibrillation</condition>
  <arm_group>
    <arm_group_label>Flecainide</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Conventional cardioversion group using intravenous flecainide.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Vernakalant</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Atria-preferential and atrial-specific blockade group using intravenous vernakalant.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Vernakalant</intervention_name>
    <description>Initial infusion: 3 mg/kg intravenously over a 10 minute period. For patients weighing ≥ 113 kg, the maximum initial dose will be 339 mg. If conversion to sinus rhythm does not occur within 15 minutes after the end of the initial infusion, a second 10 minute infusion of 2 mg/kg will be administered. For patients weighing ≥ 113 kg, the maximum second infusion will be 226 mg.</description>
    <arm_group_label>Vernakalant</arm_group_label>
    <other_name>BRINAVESS</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Flecainide</intervention_name>
    <description>2 mg /kg (max 150 mg) intravenously over 10 minutes.</description>
    <arm_group_label>Flecainide</arm_group_label>
    <other_name>APOCARD</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. Patients ≥ 20 and ≤65 year-olds.&#xD;
&#xD;
          2. Patients with paroxysmal AF lasting &lt;48 hours, in whom pharmacological cardioversion&#xD;
             may be indicated.&#xD;
&#xD;
          3. Hemodynamically stable patients (systolic blood pressure &gt; 100 mm Hg and &lt; 160 mm Hg.&#xD;
             Diastolic blood pressure &lt;95 mm Hg).&#xD;
&#xD;
          4. Weight of 45-136 kg .&#xD;
&#xD;
          5. Appropriate anticoagulation therapy according to the clinical practice guidelines of&#xD;
             the European Society of Cardiology in paroxysmal AF episodes lasting &lt; 48 hours.&#xD;
&#xD;
          6. Signed informed consent.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Corrected QT interval&gt; 440 milliseconds, long QT family or history of 'Torsades de&#xD;
             Pointes' syndrome.&#xD;
&#xD;
          2. Symptomatic bradycardia or ventricular rate &lt;50 bpm without a pacemaker, or QRS&#xD;
             interval&gt; 140 milliseconds.&#xD;
&#xD;
          3. Patients with heart failure regardless of the classification of the New York Heart&#xD;
             Association (NYHA).&#xD;
&#xD;
          4. Second or third degree atrioventricular block, or right bundle branch block associated&#xD;
             with partial left bundle branch block (bifascicular block).&#xD;
&#xD;
          5. Cardiogenic or septic shock, chronic myocardial infarction, acute coronary syndrome,&#xD;
             or heart surgery in the previous 30 days before inclusion.&#xD;
&#xD;
          6. Valvular stenosis, hypertrophic obstructive cardiomyopathy, restrictive&#xD;
             cardiomyopathy, or constrictive pericarditis.&#xD;
&#xD;
          7. Previous unsuccessful electrical cardioversion or longstanding atrial fibrillation (no&#xD;
             attempt to convert to sinus rhythm).&#xD;
&#xD;
          8. Treatment with other investigational drug within 60 days before enrollment.&#xD;
&#xD;
          9. Previous treatment with vernakalant.&#xD;
&#xD;
         10. Secondary causes of atrial fibrillation, hyperthyroidism, uncorrected electrolyte&#xD;
             imbalance, or digoxin toxicity.&#xD;
&#xD;
         11. IV / oral treatment with Class I or III antiarrhythmics (except amiodarone) in the&#xD;
             previous 48 hours.&#xD;
&#xD;
         12. Renal failure with glomerular filtration rate &lt;35 ml / min.&#xD;
&#xD;
         13. Intravenous / oral amiodarone within the previous 3 months.&#xD;
&#xD;
         14. Pregnant or nursing women.&#xD;
&#xD;
         15. Intolerance or allergy to any of the two drugs being studied.&#xD;
&#xD;
         16. Refusal to sign the informed consent.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>20 Years</minimum_age>
    <maximum_age>65 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Nicasio Pérez-Castellano, MD, PhD</last_name>
    <role>Study Chair</role>
    <affiliation>Hospital San Carlos, Madrid</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Asunción Conde, PharmD</last_name>
    <role>Study Chair</role>
    <affiliation>Hospital San Carlos, Madrid</affiliation>
  </overall_official>
  <overall_official>
    <last_name>María-Jesús García-Torrent, PharmD, PhD</last_name>
    <role>Study Chair</role>
    <affiliation>Hospital San Carlos, Madrid</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Hospital Clínico Universitario San Carlos</name>
      <address>
        <city>Madrid</city>
        <state>Madrid/Madrid</state>
        <zip>28040</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Spain</country>
  </location_countries>
  <reference>
    <citation>Kannel WB, Wolf PA, Benjamin EJ, Levy D. Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol. 1998 Oct 16;82(8A):2N-9N. doi: 10.1016/s0002-9149(98)00583-9.</citation>
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    <citation>Atienza F, Almendral J, Moreno J, Vaidyanathan R, Talkachou A, Kalifa J, Arenal A, Villacastin JP, Torrecilla EG, Sanchez A, Ploutz-Snyder R, Jalife J, Berenfeld O. Activation of inward rectifier potassium channels accelerates atrial fibrillation in humans: evidence for a reentrant mechanism. Circulation. 2006 Dec 5;114(23):2434-42. doi: 10.1161/CIRCULATIONAHA.106.633735. Epub 2006 Nov 13.</citation>
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    <citation>Castells F, Mora C, Rieta JJ, Moratal-Perez D, Millet J. Estimation of atrial fibrillatory wave from single-lead atrial fibrillation electrocardiograms using principal component analysis concepts. Med Biol Eng Comput. 2005 Sep;43(5):557-60. doi: 10.1007/BF02351028.</citation>
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    <citation>Bollmann A, Sonne K, Esperer HD, Toepffer I, Klein HU. Patients with persistent atrial fibrillation taking oral verapamil exhibit a lower atrial frequency on the ECG. Ann Noninvasive Electrocardiol. 2002 Apr;7(2):92-7. doi: 10.1111/j.1542-474x.2002.tb00148.x.</citation>
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    <citation>Bollmann A, Binias KH, Toepffer I, Molling J, Geller C, Klein HU. Importance of left atrial diameter and atrial fibrillatory frequency for conversion of persistent atrial fibrillation with oral flecainide. Am J Cardiol. 2002 Nov 1;90(9):1011-4. doi: 10.1016/s0002-9149(02)02690-5. No abstract available.</citation>
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    <citation>Bollmann A, Kanuru NK, McTeague KK, Walter PF, DeLurgio DB, Langberg JJ. Frequency analysis of human atrial fibrillation using the surface electrocardiogram and its response to ibutilide. Am J Cardiol. 1998 Jun 15;81(12):1439-45. doi: 10.1016/s0002-9149(98)00210-0.</citation>
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    <citation>Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation. 2007 Sep 25;116(13):1449-57. doi: 10.1161/CIRCULATIONAHA.107.704890. Epub 2007 Sep 4.</citation>
    <PMID>17785620</PMID>
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    <citation>Fedida D, Orth PM, Chen JY, Lin S, Plouvier B, Jung G, Ezrin AM, Beatch GN. The mechanism of atrial antiarrhythmic action of RSD1235. J Cardiovasc Electrophysiol. 2005 Nov;16(11):1227-38. doi: 10.1111/j.1540-8167.2005.50028.x.</citation>
    <PMID>16302909</PMID>
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    <citation>Duggan ST, Scott LJ. Intravenous vernakalant: a review of its use in the management of recent-onset atrial fibrillation. Drugs. 2011 Jan 22;71(2):237-52. doi: 10.2165/10489050-000000000-00000. Erratum In: Drugs. 2011 Feb 12;71(3):381.</citation>
    <PMID>21275448</PMID>
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    <citation>Feng J, Xu D, Wang Z, Nattel S. Ultrarapid delayed rectifier current inactivation in human atrial myocytes: properties and consequences. Am J Physiol. 1998 Nov;275(5):H1717-25. doi: 10.1152/ajpheart.1998.275.5.H1717.</citation>
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    <citation>Kneller J, Kalifa J, Zou R, Zaitsev AV, Warren M, Berenfeld O, Vigmond EJ, Leon LJ, Nattel S, Jalife J. Mechanisms of atrial fibrillation termination by pure sodium channel blockade in an ionically-realistic mathematical model. Circ Res. 2005 Mar 18;96(5):e35-47. doi: 10.1161/01.RES.0000160709.49633.2b.</citation>
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    <citation>Stiell IG, Roos JS, Kavanagh KM, Dickinson G. A multicenter, open-label study of vernakalant for the conversion of atrial fibrillation to sinus rhythm. Am Heart J. 2010 Jun;159(6):1095-101. doi: 10.1016/j.ahj.2010.02.035.</citation>
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  <verification_date>August 2023</verification_date>
  <study_first_submitted>December 5, 2016</study_first_submitted>
  <study_first_submitted_qc>December 23, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">December 29, 2016</study_first_posted>
  <last_update_submitted>August 4, 2023</last_update_submitted>
  <last_update_submitted_qc>August 4, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">August 7, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>Hospital San Carlos, Madrid</investigator_affiliation>
    <investigator_full_name>David Filgueiras-Rama</investigator_full_name>
    <investigator_title>MD PhD</investigator_title>
  </responsible_party>
  <keyword>Atrial fibrillation</keyword>
  <keyword>vernakalant</keyword>
  <keyword>flecainide</keyword>
  <keyword>cardioversion</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Atrial Fibrillation</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Flecainide</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03005366
org study id: SELECTI-CARFAP
nct id: NCT03005366
lead sponsor: 
collaborator: 
has dmc: Yes
-  The main objective of this project is to study the efficacy and the mechanistic value of
           blocking both atrial specific and atria-preferential dynamics of ionic currents to
           terminate paroxysmal atrial fibrillation (AF).

        -  The hypothesis is that a drug blocking atrial specific and atria-preferential dynamics
           of ionic currents (IK,ACh - acetylcholine sensitive K+ current - and INa - inward sodium
           current - , respectively) will be more effective to terminate paroxysmal AF episodes
           with fast atrial activation rates, than a classical INa blocker, which will be more
           effective to terminate AF episodes with slower activation rates.

        -  The investigators will include patients without structural heart disease and
           short-lasting AF episodes (<48 h.). Double blind and single center study, in which
           patients will be randomly assigned to a cardioversion group using intravenous flecainide
           or to an atria-preferential and atrial-specific blockade group using intravenous
           vernakalant. Patients will be routinely monitored in the electrophysiology room to
           acquire both 12-lead digitized ECG signals and non-invasive body surface potential
           mapping. Atrial signals will be extracted from both the multisite body surface and ECG
           recordings to obtain temporal and spectral parameters, and measure organization and
           atrial rate in both groups. The results obtained in the clinical setting will be studied
           in mathematical models to understand their capability to terminate paroxysmal AF. The
           project expects to provide consistent, reliable and reproducible parameters that will
           assist clinicians to know what type of paroxysmal AF episodes will be more suitable to
           effectively terminate, upon administration of drugs with an atrial specific and
           atria-preferential profile.
-  Background: Different research strategies aim at understanding the mechanisms underlying
           the maintenance of atrial fibrillation (AF), while preventing ventricular pro-arrhythmia
           related to the use of anti-arrhythmic drugs to restore sinus rhythm. Such aims might be
           achieved by drugs that effectively terminate reentrant sources identified during AF,
           along with an atrial specific and atria-preferential blockade of ionic currents. The
           latter may be especially relevant in paroxysmal AF episodes with fast atrial activation
           rates, in which INa and IK,ACh are involved in the maintenance of fast atrial reentrant
           sources underlying AF.

        -  Objective: The main objective of this project is to study the efficacy and the
           mechanistic value of blocking both atrial specific and atria-preferential dynamics of
           ionic currents to terminate paroxysmal AF.

        -  The hypothesis is that a drug blocking atrial specific and atria-preferential dynamics
           of ionic currents (IK,ACh and INa, respectively) will be more effective to terminate
           paroxysmal AF episodes with fast atrial activation rates, than a classical INa blocker,
           which will be more effective to terminate AF episodes with slower activation rates.

        -  Design: Double blind and single center study, in which patients will be randomly
           assigned to a cardioversion group using intravenous flecainide or to an
           atria-preferential and atrial-specific blockade group using intravenous vernakalant.
           Patients will be routinely monitored in the electrophysiology room for 90 minutes upon
           drug administration to acquire both 12-lead digitized ECG signals and non-invasive body
           surface potential mapping. Body surface recordings and conventional ECG signals will be
           exported to obtain temporal and spectral parameters of atrial activity during AF, and
           measure organization and atrial rate in both groups of patients undergoing
           pharmacological cardioversion. The success rate of cardioversion obtained in both groups
           will be correlated with the patterns of activation and spectral parameters obtained from
           the body surface, which will provide what type of paroxysmal AF episodes are suitable to
           terminate upon administration of anti-arrhythmic drugs with an atrial specific and
           atria-preferential profile.

      Electrical cardioversion will be performed in subjects with unsuccessful pharmacological
      cardioversion within the first 24 h. after vernakalant or flecainide administration.

      The results obtained in the clinical setting will be studied in realistic mathematical models
      to further understand the capability of both drugs to terminate paroxysmal AF.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
measure: Electrocardiographic-based spectral parameters of atrial fibrillatory activity (Dominant frequency) associated with successful or unsuccessful cardioversion in both groups of patients.
time frame: 18 months
description: The investigators will quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with successful cardioversion in the vernakalant and flecainide groups.
The investigators will also quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with successful and unsuccessful cardioversion within the vernakalant or flecainide group.
measure: Cardioversion success (yes/no) in patients with paroxysmal atrial fibrillation episodes lasting < 24 hours or ≥24 hours.
time frame: 18 months
description: The investigators will quantify the difference in cardioversion success (yes/no) between episodes lasting < 24 hours or ≥24 hours.
measure: Electrocardiographic-based spectral parameters of atrial fibrillatory activity (Dominant frequency) in patients with episodes lasting < 24 hours or ≥24 hours.
time frame: 18 months
description: The investigators will quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with episodes lasting < 24 hours or ≥24 hours.
measure: Spectral parameters of atrial fibrillatory activity (Dominant frequency) recorded by non-invasive body surface potential mapping associated with successful or unsuccessful cardioversion in both groups of patients.
time frame: 24 months
description: The investigators will quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with successful cardioversion in the vernakalant and flecainide groups.
The investigators will also quantify the difference in baseline dominant frequency values (Hz) of atrial fibrillatory activity between patients with successful and unsuccessful cardioversion within the vernakalant or flecainide group.
measure: Effects on reentrant-based atrial fibrillation (dominant frequency decrease, rotor meandering) in 2D models of fast and low atrial activation rates under the effect of vernakalant or flecainide.
time frame: 24 months
description: The investigators will quantify dominant frequency changes (Hz) and rotor meandering (mm) under the effect of vernakalant or flecainide in 2D computational models.
measure: Atrial Fibrillation Quality of Life questionnaire (AF-QOL).
time frame: 24 months
description: The Investigators will quantify the effects of atrial fibrillation on patients´ quality of life base on of the Atrial Fibrillation Quality of Life questionnaire (AF-QOL).
measure: Patient's perception during cardioversion. The investigators will used a custom-designed five-question questionnaire as follows:
time frame: 24 months
description: i) Do you recall something from the cardioversion attempt? yes/no. ii) If (1) is yes, was it uncomfortable? yes/no. iii) Did you feel any pain during the cardioversion attempt? yes/no. iv) Please, provide an score from '0' to '10' to evaluate your general perception of the cardioversion attempt.
v) If necessary, would you undergo another cardioversion attempt using the same strategy? yes/no.
arm group label: Flecainide
arm group type: Active Comparator
description: Conventional cardioversion group using intravenous flecainide.
arm group label: Vernakalant
arm group type: Active Comparator
description: Atria-preferential and atrial-specific blockade group using intravenous vernakalant.
intervention type: Drug
intervention name: Vernakalant
description: Initial infusion: 3 mg/kg intravenously over a 10 minute period. For patients weighing ≥ 113 kg, the maximum initial dose will be 339 mg. If conversion to sinus rhythm does not occur within 15 minutes after the end of the initial infusion, a second 10 minute infusion of 2 mg/kg will be administered. For patients weighing ≥ 113 kg, the maximum second infusion will be 226 mg.
arm group label: Vernakalant
other name: BRINAVESS
intervention type: Drug
intervention name: Flecainide
description: 2 mg /kg (max 150 mg) intravenously over 10 minutes.
arm group label: Flecainide
other name: APOCARD
criteria: 
gender: All
minimum age: 20 Years
maximum age: 65 Years
healthy volunteers: No
last name: Nicasio Pérez-Castellano, MD, PhD
role: Study Chair
affiliation: Hospital San Carlos, Madrid
last name: Asunción Conde, PharmD
role: Study Chair
affiliation: Hospital San Carlos, Madrid
last name: María-Jesús García-Torrent, PharmD, PhD
role: Study Chair
affiliation: Hospital San Carlos, Madrid
facility: 
country: Spain
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responsible party type: Sponsor-Investigator
investigator affiliation: Hospital San Carlos, Madrid
investigator full name: David Filgueiras-Rama
investigator title: MD PhD
mesh term: Atrial Fibrillation
mesh term: Flecainide
sharing ipd: No