<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03004755</url>
  </required_header>
  <id_info>
    <org_study_id>UCL/13/0165</org_study_id>
    <nct_id>NCT03004755</nct_id>
  </id_info>
  <brief_title>The PEACE (Posthumous Evaluation of Advanced Cancer Environment) Study</brief_title>
  <acronym>PEACE</acronym>
  <official_title>The PEACE (Posthumous Evaluation of Advanced Cancer Environment) Study</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University College, London</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Cancer Research UK</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>University College, London</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      Historically, cancer research has been limited by sample acquisition in late stage disease,&#xD;
      often restricted to single sites of disease with limited parallel clinical data collection in&#xD;
      terms of prior therapy exposure. The PEACE study is intended to facilitate tissue donation&#xD;
      from multiple tumour sites in the post-mortem setting and enable future research using&#xD;
      samples collected at post-mortem within different disciplines related to cancer research.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Recruiting</overall_status>
  <start_date>March 2014</start_date>
  <completion_date type="Anticipated">November 2023</completion_date>
  <primary_completion_date type="Anticipated">November 2023</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Perform 500 post mortems</measure>
    <time_frame>5 years</time_frame>
  </primary_outcome>
  <enrollment type="Anticipated">500</enrollment>
  <condition>Solid Tumor, Adult</condition>
  <condition>Cancer</condition>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Tissue Harvest</intervention_name>
  </intervention>
  <eligibility>
    <study_pop>
      <textblock>
        Solid tumour malignancy with metastatic disease&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Age 18 years or older&#xD;
&#xD;
          -  Confirmed diagnosis of any form of solid malignancy with metastatic disease (where the&#xD;
             site of origin is known or unknown), with the exception of primary brain tumour in&#xD;
             which there may not be evidence of metastatic disease&#xD;
&#xD;
          -  Oral and written informed consent from patient to enter the study and to undergo&#xD;
             tumour harvesting after death or informed consent from a person in a qualifying&#xD;
             relationship after the patient has died.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Medical or psychiatric condition that would preclude informed consent&#xD;
&#xD;
          -  History of intravenous drug abuse within the last 5 years&#xD;
&#xD;
          -  History of known high-risk infections (e.g. HIV/AIDS-positive, hepatitis B/C,&#xD;
             tuberculosis and Creutzfeldt-Jacob disease).&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_contact>
    <last_name>Abby Sharp</last_name>
    <phone>02076799688</phone>
    <email>ctc.peace@ucl.ac.uk</email>
  </overall_contact>
  <location>
    <facility>
      <name>Heart of England NHS Foundation Trust</name>
      <address>
        <city>Birmingham</city>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location>
    <facility>
      <name>Cambridge University NHS Trust</name>
      <address>
        <city>Cambridge</city>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location>
    <facility>
      <name>Greater Glasgow Health Board</name>
      <address>
        <city>Glasgow</city>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location>
    <facility>
      <name>University Hospitals of Leicester NHS Trust</name>
      <address>
        <city>Leicester</city>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location>
    <facility>
      <name>Guy's and St Thomas NHS Foundation Trust</name>
      <address>
        <city>London</city>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location>
    <facility>
      <name>The Royal Marsden NHS Foundation Trust</name>
      <address>
        <city>London</city>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location>
    <facility>
      <name>University College London Hospitals NHS Foundation Trust</name>
      <address>
        <city>London</city>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location>
    <facility>
      <name>The Christie NHS Foundation Trust</name>
      <address>
        <city>Manchester</city>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Recruiting</status>
  </location>
  <location>
    <facility>
      <name>Oxford University Hospitals NHS Trust</name>
      <address>
        <city>Oxford</city>
        <country>United Kingdom</country>
      </address>
    </facility>
    <status>Not yet recruiting</status>
  </location>
  <location_countries>
    <country>United Kingdom</country>
  </location_countries>
  <verification_date>February 2022</verification_date>
  <study_first_submitted>December 21, 2016</study_first_submitted>
  <study_first_submitted_qc>December 23, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">December 29, 2016</study_first_posted>
  <last_update_submitted>February 22, 2022</last_update_submitted>
  <last_update_submitted_qc>February 22, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">February 23, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03004755
org study id: UCL/13/0165
nct id: NCT03004755
lead sponsor: 
collaborator: 
has dmc: Yes
Historically, cancer research has been limited by sample acquisition in late stage disease,
      often restricted to single sites of disease with limited parallel clinical data collection in
      terms of prior therapy exposure. The PEACE study is intended to facilitate tissue donation
      from multiple tumour sites in the post-mortem setting and enable future research using
      samples collected at post-mortem within different disciplines related to cancer research.
observational model: Cohort
time perspective: Prospective
measure: Perform 500 post mortems
time frame: 5 years
intervention type: Other
intervention name: Tissue Harvest
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Abby Sharp
phone: 02076799688
email: ctc.peace@ucl.ac.uk
facility: 
status: Recruiting
facility: 
status: Recruiting
facility: 
status: Recruiting
facility: 
status: Recruiting
facility: 
status: Recruiting
facility: 
status: Recruiting
facility: 
status: Recruiting
facility: 
status: Recruiting
facility: 
status: Not yet recruiting
country: United Kingdom
responsible party type: Sponsor