<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02986919</url>
  </required_header>
  <id_info>
    <org_study_id>STU 092016-074</org_study_id>
    <nct_id>NCT02986919</nct_id>
  </id_info>
  <brief_title>Study of CPI-0610 in Patients With Malignant Peripheral Nerve Sheath Tumors</brief_title>
  <official_title>A Phase 2 Study of CPI-0610, a Small Molecule Inhibitor of Bromodomain and Extra-Terminal (BET) Proteins, in Patients With Malignant Peripheral Nerve Sheath Tumors</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Texas Southwestern Medical Center</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>University of Texas Southwestern Medical Center</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
    <is_fda_regulated_drug>Yes</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
    <is_us_export>No</is_us_export>
  </oversight_info>
  <brief_summary>
    <textblock>
      Establish safety and toxicity profile and preliminary response rate of CPI-0610 in MPNST&#xD;
      patients and correlate response with pharmacodynamics markers and BET inhibition.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      -  Optional tumor biopsy will be obtained prior to Day 1 of CPI-0610 administration.&#xD;
&#xD;
        -  CPI-0610 will be administered 200mg orally once a daily for 14 consecutive days followed&#xD;
           by a 7-day break. The 14 days of CPI-0610 dosing and the 7-day break together constitute&#xD;
           1 cycle of treatment. The dose will not be adjusted for body weight or body surface&#xD;
           area.&#xD;
&#xD;
        -  Patients should be instructed to take their daily dose at approximately the same time of&#xD;
           day. Each dose should be taken with a glass of water and consumed over as short a time&#xD;
           as possible-e.g., within 5 minutes. Patients should be instructed to swallow the tablet&#xD;
           whole and to not chew or cut them.&#xD;
&#xD;
        -  Doses may be taken either with or without food.&#xD;
&#xD;
        -  If vomiting occurs during the course of treatment, then no re-dosing of the patient is&#xD;
           allowed before the next scheduled dose.&#xD;
&#xD;
        -  If the patient forgets to take his/her daily morning dose, then he/she should take&#xD;
           CPI-0610 within 6 hours after the missed dose. If more than 6 hours have passed, then&#xD;
           that day's dose should be omitted, and the patient should resume treatment with the next&#xD;
           scheduled dose.&#xD;
&#xD;
        -  Repeat optional tumor biopsy will be obtained on day 8 of CPI-0610 treatment.&#xD;
&#xD;
      Toxicities and Dosing Delays/Dose Modifications During a cycle of treatment, CPI-0610 should&#xD;
      continue to be administered as planned unless CTCAE grade 3-4 toxicities occur. In the case&#xD;
      of CPI-0610-related neutropenia and/or thrombocytopenia, dosing as planned should continue as&#xD;
      long as the ANC remains &gt;0.5x109/L and the platelet count remains &gt;25x109/L. Should either&#xD;
      the ANC or platelet count fall below these values-become CTCAE grade 4-dosing with CPI-0610&#xD;
      should be interrupted. CPI-0610 dosing within the planned 14 days of treatment should not be&#xD;
      resumed until the ANC is &gt;0.75x109/L and the platelet count is &gt;50x109/L. In addition, dosing&#xD;
      within the cycle of treatment should not be resumed if the interruption has resulted in the&#xD;
      omission of more than 2 of the planned 14 days of dosing. If it is possible to resume dosing&#xD;
      within the planned 14 days of treatment, no attempt should be made to make up the missed&#xD;
      doses of CPI-0610. If more than 2 of the planned 14 days of therapy have been omitted, then&#xD;
      treatment should be resumed only with a new cycle of treatment, if the ANC&gt;1x109/L and the&#xD;
      platelet count &gt;75x109/L. In addition, all other toxicities considered to be related to&#xD;
      CPI-0610 must have resolved to CTCAE grade 1 or baseline. If the patient fails to meet the&#xD;
      above-cited criteria for retreatment, then initiation of the next cycle of treatment should&#xD;
      be delayed by one week. Following the additional week of no treatment, the next cycle may&#xD;
      begin if the patient's ANC is&gt;1x109/L and the platelet count is &gt;75x109/L. In addition, all&#xD;
      other toxicities considered to be related to CPI-0610 must have resolved to CTCAE grade 1 or&#xD;
      baseline. If there are more than 28 days between the start of one cycle and the start of the&#xD;
      next, the patient will no longer receive CPI-0610 therapy unless the patient's MPNST is&#xD;
      stable or responding to therapy. Then consideration may be given to resuming treatment at a&#xD;
      lower dose level to be discussed with Sponsor and Institutional Review Board (IRB). When a&#xD;
      reduction in dose of CPI-0610 is required, no re-escalation of dose will be permitted.&#xD;
&#xD;
      Exceptions to the toxicity delay are CTCAE elevations in alkaline phosphatase and uric acid&#xD;
      and &lt;72 hours of grade 3 fatigue. When laboratory abnormalities form the basis of treatment&#xD;
      decisions, they should be confirmed by repeated testing with a new blood sample or procedure.&#xD;
      Optimal therapy for vomiting or diarrhea is based on physician preference with consideration&#xD;
      of the prohibited medications listed in the appendix. G-CSF may be used to treat patients who&#xD;
      have developed dose-limiting neutropenia, as per institutional guidelines, following&#xD;
      discontinuation of CPI-0610 treatment. However, G-CSF may not be used during CPI-0610&#xD;
      administration or during the treatment break. Patients should not have dose reductions of&#xD;
      CPI-0610 unless a grade 3-4 toxicity occurs and retreatment is not possible within the 28 day&#xD;
      period. Then the patient is withdrawn from study unless the patient's MPNST has responded or&#xD;
      stable on therapy. Then consideration may be given to resuming treatment at a lower dose&#xD;
      level to be discussed with Sponsor and IRB. When a reduction in the dose of CPI-0610 is&#xD;
      required, no re-escalation of dose will be permitted. Patients whose treatment is interrupted&#xD;
      or permanently discontinued because of toxicities must be followed until the toxicity&#xD;
      resolves or stabilizes.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Withdrawn</overall_status>
  <why_stopped>
    Lack of enrollment.&#xD;
  </why_stopped>
  <start_date type="Actual">May 5, 2017</start_date>
  <completion_date type="Actual">May 17, 2018</completion_date>
  <primary_completion_date type="Actual">May 17, 2018</primary_completion_date>
  <phase>Phase 2</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>N/A</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Response rate of CPI-0610</measure>
    <time_frame>21 day cycles for 84 days</time_frame>
    <description>Establish the response rate of CPI-0610 in MPNST patients</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Duration of CPI-0610</measure>
    <time_frame>21 day cycles for 84 days</time_frame>
    <description>Establish the response duration of CPI-0610 in MPNST patients</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Adverse events associated with CPI-0610</measure>
    <time_frame>21 day cycles for 84 days</time_frame>
    <description>Describe the adverse events associated with CPI-0610 at the RP2D</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Correlate tumor exposure to CPI-0610 with tumor BIM1 expression</measure>
    <time_frame>21 day cycles for 84 days</time_frame>
    <description>Correlate tumor exposure to CPI-0610 with tumor BIM1 expression</description>
  </secondary_outcome>
  <number_of_arms>1</number_of_arms>
  <enrollment type="Actual">0</enrollment>
  <condition>Peripheral Nerve Tumors</condition>
  <arm_group>
    <arm_group_label>CPI-0610 Treatment</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>CPI-0610 will be administered 200mg orally once a daily for 14 consecutive days followed by a 7-day break.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>CPI-0610</intervention_name>
    <description>Optional tumor biopsy will be obtained prior to Day 1 of CPI-0610 administration.&#xD;
CPI-0610 will be administered 200mg orally once a daily for 14 consecutive days followed by a 7-day break. The 14 days of CPI-0610 dosing and the 7-day break together constitute 1 cycle of treatment. The dose will not be adjusted for body weight or body surface area.</description>
    <arm_group_label>CPI-0610 Treatment</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. Age &gt;18 years&#xD;
&#xD;
          2. Must have histologically confirmed diagnosis of MPNST&#xD;
&#xD;
          3. Must have measurable disease by CT scan or MRI&#xD;
&#xD;
          4. Eastern Cooperative Oncology Group - ECOG performance status &lt;2&#xD;
&#xD;
          5. Adequate organ and marrow function as defined below:&#xD;
&#xD;
               -  absolute neutrophil count greater than or equal to 1,000/mcL&#xD;
&#xD;
               -  platelets greater than or equal to 75,000/mcL&#xD;
&#xD;
               -  total bilirubin &lt;2X normal institutional limits&#xD;
&#xD;
               -  AST(SGOT)/ALT(SPGT) greater than or equal to 2.5 X institutional upper limit of&#xD;
                  normal&#xD;
&#xD;
               -  creatinine &lt;2X institutional upper limit of normal&#xD;
&#xD;
          6. Patients must have fully recovered from major surgery and from the acute toxic effects&#xD;
             of prior chemotherapy and radiotherapy - residual grade 1 toxicity, e.g., grade 1&#xD;
             peripheral neuropathy and residual alopecia are allowed.&#xD;
&#xD;
          7. Female patients who are pre-menopausal or have experienced menopause for less than 2&#xD;
             years must have a negative serum pregnancy test &lt;72 hours before starting study&#xD;
             treatment. Male and female patients with reproductive potential must agree to use&#xD;
             appropriate contraceptive methods while on study and for 3 months after the last dose&#xD;
             of CPI-0610. Should a woman become pregnant or suspect she is pregnant while&#xD;
             participating in this study, she should inform her treating physician immediately.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Current infection with HIV, hepatitis B or hepatitis C. Patients will have serologic&#xD;
             testing performed during screening for HIV and hepatitis B and C. Any serologic&#xD;
             results suggestive of an ongoing viral infection will be further investigated as&#xD;
             necessary to clarify the patient's status.&#xD;
&#xD;
          2. Impairment of gastrointestinal (GI) function or GI disease that may significantly&#xD;
             alter the absorption of CPI-0610, including any unresolved nausea, vomiting, or&#xD;
             diarrhea that is CTCAE grade &gt;1.&#xD;
&#xD;
          3. Impaired cardiac function or clinically significant cardiac diseases, including any of&#xD;
             the following:&#xD;
&#xD;
             Acute myocardial infarction or angina pectoris &lt;6 months prior to starting study drug&#xD;
&#xD;
          4. Uncontrolled cardiac arrhythmia - patients with rate-controlled atrial fibrillation&#xD;
             are not excluded.&#xD;
&#xD;
          5. A past medical history of other clinically significant cardiovascular disease - e.g.,&#xD;
             uncontrolled hypertension, history of labile hypertension or history of poor&#xD;
             compliance with an antihypertensive regimen.&#xD;
&#xD;
          6. Any other concurrent severe and/or uncontrolled concomitant medical condition that&#xD;
             could compromise participation in the study - e.g., clinically significant pulmonary&#xD;
             disease, clinically significant neurological disorder, active or uncontrolled&#xD;
             infection.&#xD;
&#xD;
          7. Systemic anti-cancer treatment or radiotherapy less than 2 weeks before the first dose&#xD;
             of CPI-0610.&#xD;
&#xD;
          8. Treatment with an investigational small molecule less than 2 weeks before the first&#xD;
             dose of CPI-0610.&#xD;
&#xD;
          9. Immunosuppressive treatment that cannot be discontinued prior to study entry and for&#xD;
             the duration of the study. Immunosuppressive treatment should be discontinued for at&#xD;
             least 1 week prior to start of the administration of CPI-0610. Oral prednisone at a&#xD;
             dose of 10mg or less per day is allowed, as are other oral corticosteroids given at&#xD;
             glucocorticoid-equivalent doses. Topical, nasal and inhaled corticosteroids are also&#xD;
             allowed.&#xD;
&#xD;
         10. Pregnant or lactating women.&#xD;
&#xD;
         11. Women of child bearing potential and men with reproductive potential, if they are&#xD;
             unwilling to use adequate contraception while on study therapy and for 3 months&#xD;
             thereafter.&#xD;
&#xD;
         12. Use of strong CYP inhibitors or drugs that carry a definite risk of Torsades de&#xD;
             Pointes.&#xD;
&#xD;
         13. Patients unwilling or unable to comply with the study protocol.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>University of Texas Southwestern Medical Center</name>
      <address>
        <city>Dallas</city>
        <state>Texas</state>
        <zip>75390</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <verification_date>September 2018</verification_date>
  <study_first_submitted>November 21, 2016</study_first_submitted>
  <study_first_submitted_qc>December 5, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">December 8, 2016</study_first_posted>
  <last_update_submitted>September 7, 2018</last_update_submitted>
  <last_update_submitted_qc>September 7, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">September 11, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Malignant peripheral Nerve Sheath Tumors (MPNST); Neurofibromatosis sarcoma</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Nerve Sheath Neoplasms</mesh_term>
    <mesh_term>Neurofibrosarcoma</mesh_term>
    <mesh_term>Peripheral Nervous System Neoplasms</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02986919
org study id: STU 092016-074
nct id: NCT02986919
lead sponsor: 
has dmc: Yes
is fda regulated drug: Yes
is fda regulated device: No
is us export: No
Establish safety and toxicity profile and preliminary response rate of CPI-0610 in MPNST
      patients and correlate response with pharmacodynamics markers and BET inhibition.
-  Optional tumor biopsy will be obtained prior to Day 1 of CPI-0610 administration.

        -  CPI-0610 will be administered 200mg orally once a daily for 14 consecutive days followed
           by a 7-day break. The 14 days of CPI-0610 dosing and the 7-day break together constitute
           1 cycle of treatment. The dose will not be adjusted for body weight or body surface
           area.

        -  Patients should be instructed to take their daily dose at approximately the same time of
           day. Each dose should be taken with a glass of water and consumed over as short a time
           as possible-e.g., within 5 minutes. Patients should be instructed to swallow the tablet
           whole and to not chew or cut them.

        -  Doses may be taken either with or without food.

        -  If vomiting occurs during the course of treatment, then no re-dosing of the patient is
           allowed before the next scheduled dose.

        -  If the patient forgets to take his/her daily morning dose, then he/she should take
           CPI-0610 within 6 hours after the missed dose. If more than 6 hours have passed, then
           that day's dose should be omitted, and the patient should resume treatment with the next
           scheduled dose.

        -  Repeat optional tumor biopsy will be obtained on day 8 of CPI-0610 treatment.

      Toxicities and Dosing Delays/Dose Modifications During a cycle of treatment, CPI-0610 should
      continue to be administered as planned unless CTCAE grade 3-4 toxicities occur. In the case
      of CPI-0610-related neutropenia and/or thrombocytopenia, dosing as planned should continue as
      long as the ANC remains >0.5x109/L and the platelet count remains >25x109/L. Should either
      the ANC or platelet count fall below these values-become CTCAE grade 4-dosing with CPI-0610
      should be interrupted. CPI-0610 dosing within the planned 14 days of treatment should not be
      resumed until the ANC is >0.75x109/L and the platelet count is >50x109/L. In addition, dosing
      within the cycle of treatment should not be resumed if the interruption has resulted in the
      omission of more than 2 of the planned 14 days of dosing. If it is possible to resume dosing
      within the planned 14 days of treatment, no attempt should be made to make up the missed
      doses of CPI-0610. If more than 2 of the planned 14 days of therapy have been omitted, then
      treatment should be resumed only with a new cycle of treatment, if the ANC>1x109/L and the
      platelet count >75x109/L. In addition, all other toxicities considered to be related to
      CPI-0610 must have resolved to CTCAE grade 1 or baseline. If the patient fails to meet the
      above-cited criteria for retreatment, then initiation of the next cycle of treatment should
      be delayed by one week. Following the additional week of no treatment, the next cycle may
      begin if the patient's ANC is>1x109/L and the platelet count is >75x109/L. In addition, all
      other toxicities considered to be related to CPI-0610 must have resolved to CTCAE grade 1 or
      baseline. If there are more than 28 days between the start of one cycle and the start of the
      next, the patient will no longer receive CPI-0610 therapy unless the patient's MPNST is
      stable or responding to therapy. Then consideration may be given to resuming treatment at a
      lower dose level to be discussed with Sponsor and Institutional Review Board (IRB). When a
      reduction in dose of CPI-0610 is required, no re-escalation of dose will be permitted.

      Exceptions to the toxicity delay are CTCAE elevations in alkaline phosphatase and uric acid
      and <72 hours of grade 3 fatigue. When laboratory abnormalities form the basis of treatment
      decisions, they should be confirmed by repeated testing with a new blood sample or procedure.
      Optimal therapy for vomiting or diarrhea is based on physician preference with consideration
      of the prohibited medications listed in the appendix. G-CSF may be used to treat patients who
      have developed dose-limiting neutropenia, as per institutional guidelines, following
      discontinuation of CPI-0610 treatment. However, G-CSF may not be used during CPI-0610
      administration or during the treatment break. Patients should not have dose reductions of
      CPI-0610 unless a grade 3-4 toxicity occurs and retreatment is not possible within the 28 day
      period. Then the patient is withdrawn from study unless the patient's MPNST has responded or
      stable on therapy. Then consideration may be given to resuming treatment at a lower dose
      level to be discussed with Sponsor and IRB. When a reduction in the dose of CPI-0610 is
      required, no re-escalation of dose will be permitted. Patients whose treatment is interrupted
      or permanently discontinued because of toxicities must be followed until the toxicity
      resolves or stabilizes.
allocation: N/A
intervention model: Single Group Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Response rate of CPI-0610
time frame: 21 day cycles for 84 days
description: Establish the response rate of CPI-0610 in MPNST patients
measure: Duration of CPI-0610
time frame: 21 day cycles for 84 days
description: Establish the response duration of CPI-0610 in MPNST patients
measure: Adverse events associated with CPI-0610
time frame: 21 day cycles for 84 days
description: Describe the adverse events associated with CPI-0610 at the RP2D
measure: Correlate tumor exposure to CPI-0610 with tumor BIM1 expression
time frame: 21 day cycles for 84 days
description: Correlate tumor exposure to CPI-0610 with tumor BIM1 expression
arm group label: CPI-0610 Treatment
arm group type: Experimental
description: CPI-0610 will be administered 200mg orally once a daily for 14 consecutive days followed by a 7-day break.
intervention type: Drug
intervention name: CPI-0610
description: Optional tumor biopsy will be obtained prior to Day 1 of CPI-0610 administration.
CPI-0610 will be administered 200mg orally once a daily for 14 consecutive days followed by a 7-day break. The 14 days of CPI-0610 dosing and the 7-day break together constitute 1 cycle of treatment. The dose will not be adjusted for body weight or body surface area.
arm group label: CPI-0610 Treatment
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
facility: 
country: United States
responsible party type: Sponsor
mesh term: Nerve Sheath Neoplasms
mesh term: Neurofibrosarcoma
mesh term: Peripheral Nervous System Neoplasms
sharing ipd: No