<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03008733</url>
  </required_header>
  <id_info>
    <org_study_id>16-AOIP-02</org_study_id>
    <nct_id>NCT03008733</nct_id>
  </id_info>
  <brief_title>Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuropathy With Antibody A MAG</brief_title>
  <acronym>EchoNerf</acronym>
  <official_title>Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuropathy With Antibody A MAG</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Centre Hospitalier Universitaire de Nice</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Centre Hospitalier Universitaire de Nice</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
    <is_fda_regulated_drug>No</is_fda_regulated_drug>
    <is_fda_regulated_device>No</is_fda_regulated_device>
  </oversight_info>
  <brief_summary>
    <textblock>
      The use of nerve ultrasound for the diagnosis and monitoring of neuromuscular diseases is a&#xD;
      promising growing field (1). Non-invasive and painless, ultrasound provides additional data&#xD;
      electroneuromyography (EMG), with a spatial resolution at least as good as MRI, while being&#xD;
      easily accessible and inexpensive.The polyradiculoneuritis Inflammatory Demyelinating&#xD;
      Chronicles (IPDC), Neuropathies Motrices in Multifocal Conduction Blocks (NMMBC) and&#xD;
      neuropathy associated with anti-MAG antibodies are among the major chronic inflammatory&#xD;
      neuropathies with an autoimmune etiology. The diagnosis of these pathologies is based on the&#xD;
      clinic, diagnostic tests and EMG. The interest not only in the diagnosis, but also for&#xD;
      monitoring these pathologies using ultrasound analysis nerves has been demonstrated recently&#xD;
      in several studies. However the limited resolution of current ultrasound images do not allow&#xD;
      detailed study of the internal structure of the nerves which could later help deepen&#xD;
      knowledge in this innovative field and can better understand the pathophysiological mechanism&#xD;
      of the evolution of these pathologies .&#xD;
&#xD;
      To do this, the investigators have available a UHF ultrasound in the ultrasound department of&#xD;
      the Nice University Hospital Pasteur Hospital 2 The investigators realize a descriptive&#xD;
      analysis study, pilot, mono-centric, multi and prospective on patients followed in the center&#xD;
      with a diagnosis of IPDC, a NMMBC or neuropathy with anti-MAG antibodies and control subjects&#xD;
      matched by age and sex. All the patients and controls in this study will receive a briefing&#xD;
      and must sign an informed consent.&#xD;
&#xD;
      They realize an ultrasound study of the nerve, using an ultra high frequency ultrasound&#xD;
      system that will allow the assessment of anatomical structures of nerve (size, structure,&#xD;
      vascularisation and assessment booklets). Ultrasound data will, in a second stage, compared&#xD;
      with the data obtained with the EMG and clinical scores obtained using clinical rating&#xD;
      scales. 40 subjects will be included, divided into four subgroups: 10 subjects with a&#xD;
      diagnosis of IPDC (1), 10 subjects with a diagnosis of NMMBC (2), 10 subjects with a&#xD;
      diagnosis of neuropathy antibody-anti MAG (3) and 10 control subjects with no signs of&#xD;
      neuropathy at the EMG examination.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The use of nerve ultrasound for the diagnosis and monitoring of neuromuscular diseases is a&#xD;
      promising growing field (1). Non-invasive and painless, ultrasound provides additional data&#xD;
      electroneuromyography (EMG), with a spatial resolution at least as good as MRI, while being&#xD;
      easily accessible and inexpensive.The polyradiculoneuritis Inflammatory Demyelinating&#xD;
      Chronicles (IPDC), Neuropathies Motrices in Multifocal Conduction Blocks (NMMBC) and&#xD;
      neuropathy associated with anti-MAG antibodies are among the major chronic inflammatory&#xD;
      neuropathies with an autoimmune etiology. The diagnosis of these pathologies is based on the&#xD;
      clinic, diagnostic tests and EMG. The interest not only in the diagnosis, but also for&#xD;
      monitoring these pathologies using ultrasound analysis nerves has been demonstrated recently&#xD;
      in several studies. However the limited resolution of current ultrasound images do not allow&#xD;
      detailed study of the internal structure of the nerves which could later help deepen&#xD;
      knowledge in this innovative field and can better understand the pathophysiological mechanism&#xD;
      of the evolution of these pathologies .&#xD;
&#xD;
      To do this, the investigators have available a UHF ultrasound in the ultrasound department of&#xD;
      the Nice University Hospital Pasteur Hospital 2 The investigators realize a descriptive&#xD;
      analysis study, pilot, mono-centric, multi and prospective on patients followed in the center&#xD;
      with a diagnosis of IPDC, a NMMBC or neuropathy with anti-MAG antibodies and control subjects&#xD;
      matched by age and sex. All the patients and controls in this study will receive a briefing&#xD;
      and must sign an informed consent.&#xD;
&#xD;
      They realize an ultrasound study of the nerve, using an ultra high frequency ultrasound&#xD;
      system that will allow the assessment of anatomical structures of nerve (size, structure,&#xD;
      vascularisation and assessment booklets). Ultrasound data will, in a second stage, compared&#xD;
      with the data obtained with the EMG and clinical scores obtained using clinical rating&#xD;
      scales. 40 subjects will be included, divided into four subgroups: 10 subjects with a&#xD;
      diagnosis of IPDC (1), 10 subjects with a diagnosis of NMMBC (2), 10 subjects with a&#xD;
      diagnosis of neuropathy antibody-anti MAG (3) and 10 control subjects with no signs of&#xD;
      neuropathy at the EMG examination.&#xD;
&#xD;
      The main objective of this pilot study is to provide a descriptive analysis of the morphology&#xD;
      of the nerves with an ultra high frequency ultrasound in subgroups of CIDP patients, anti-MAG&#xD;
      antibodies and neuropathy NMMBC and controls. The thickness of the epineurium, the hallmarks&#xD;
      of fascicular organization, Doppler vascularity, the nerve-sectional area, the specification&#xD;
      of the section surface, nerve hypertrophy, the thickness of the perineurium and&#xD;
      ultrastructural characterization of the different fascicular organization typologies will be&#xD;
      well analyzed in order to better understand the specific sonographic characteristics of each&#xD;
      disease compared with controls, no data exist at present in the literature with such image&#xD;
      resolution.&#xD;
&#xD;
      Secondary objectives:&#xD;
&#xD;
        1. Compare the morphological characteristics obtained by ultra high frequency ultrasound&#xD;
           between different subjects subgroups according to the morphological data collected and&#xD;
           sonographic scores: evaluation of nerve hypertrophy (intra- and inter-ratio nerve nerve)&#xD;
           (4 ) and intra-fascicular nerve and nerve cross-ratio.&#xD;
&#xD;
        2. To study the correlation between sonographic and clinical scores scores in different&#xD;
           subjects subgroups using functional assessment scales: MRC score, R-ODS score, INCAT,&#xD;
           ONLS, ataxia Score and a torque rating of grip strength.&#xD;
&#xD;
        3. To study the correlation between sonographic scores and electrophysiological scores by&#xD;
           making a électroneurogramme (ENG) in the different subjects of subgroups: the amplitude&#xD;
           and distal motor latency for distal motor conduction, the motor conduction velocities,&#xD;
           the presence of time dispersion or of a conduction block to the stepped motor&#xD;
           conduction, the latency of the waveform F to the proximal motor conduction and the&#xD;
           amplitude of the sensory potential for sensory conduction.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">June 26, 2018</start_date>
  <completion_date type="Actual">September 30, 2021</completion_date>
  <primary_completion_date type="Actual">December 31, 2020</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Non-Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Basic Science</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>morphology of the nerves by means of an ultra-high frequency ultrasound in patients subgroups CIDP, anti-MAG antibodies and NMMBC neuropathy and control subjects.</measure>
    <time_frame>through study completion an average of 3 years</time_frame>
  </primary_outcome>
  <number_of_arms>4</number_of_arms>
  <enrollment type="Actual">36</enrollment>
  <condition>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</condition>
  <arm_group>
    <arm_group_label>NMMCB</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>patient with Neuropathies with Motrices Multifocal Conduction Block</description>
  </arm_group>
  <arm_group>
    <arm_group_label>PICD</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>patient with Inflammatory demyelinating polyneuropathy Chronicle</description>
  </arm_group>
  <arm_group>
    <arm_group_label>anti MAG</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>patient with neuropathy antibody Anti-MAG</description>
  </arm_group>
  <arm_group>
    <arm_group_label>healthy</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>healthy patient</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Ultrasound UHF peripheral nerves</intervention_name>
    <description>Ultrasound UHF peripheral nerves</description>
    <arm_group_label>NMMCB</arm_group_label>
    <arm_group_label>PICD</arm_group_label>
    <arm_group_label>anti MAG</arm_group_label>
    <arm_group_label>healthy</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Electro myography surface nerves</intervention_name>
    <description>Electro myography surface nerves</description>
    <arm_group_label>NMMCB</arm_group_label>
    <arm_group_label>PICD</arm_group_label>
    <arm_group_label>anti MAG</arm_group_label>
    <arm_group_label>healthy</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
        common inclusion criteria for all subjects:&#xD;
&#xD;
          -  Man or woman age ≥ 18 years.&#xD;
&#xD;
          -  Affiliation to social security.&#xD;
&#xD;
          -  Signature of informed consent.&#xD;
&#xD;
        Inclusion criteria for CIDP patients:&#xD;
&#xD;
        - Patients with certain IPDC according to the following criteria defined by the EFNS 2010:&#xD;
&#xD;
        At least one of demyelination following criteria must be present:&#xD;
&#xD;
          -  Extension of the Distal Motor Latency ≥ 50% above the limit Normale Supérieure (LNS)&#xD;
             in 2 nerves (excluding impairment of the median nerve at the wrist due to carpal&#xD;
             tunnel syndrome);&#xD;
&#xD;
          -  Reducing the speed of conduction Average ≥ 30% below the normal limit Lower (LNI) in 2&#xD;
             nerves;&#xD;
&#xD;
          -  Extension of the latency of the F wave ≥ 30% above the ULN in two nerves (≥ 50% of the&#xD;
             LNS if the amplitude of distal negative peak PAGM (Action Potential Global Muscle) is&#xD;
             &lt; 80% of the LNI;&#xD;
&#xD;
          -  Lack wave F in 2 nerves if these nerves have an amplitude of the negative peak of the&#xD;
             distal PAGM ≥ 20% of the LNS + ≥ 1 other parameter of demyelination in * ≥ 1 other&#xD;
             nerve;&#xD;
&#xD;
          -  Conduction Block partial engine: decreased range ≥ 50% of the negative peak of the&#xD;
             proximal to the distal PAGM PAGM, if the negative peak of the distal PAGM ≥ 20% LNI in&#xD;
             2 nerves or nerve + 1 ≥ 1 another parameter of demyelination in ≥ 1 * other nerve;&#xD;
&#xD;
          -  abnormal temporal dispersion (&gt; 30% increase in duration between the negative peak of&#xD;
             the proximal and distal PAGM) ≥ 2 in nerves;&#xD;
&#xD;
          -  PAGM distal length (interval between the start of the negative peak and its return to&#xD;
             baseline) in ≥ 1 nerve (median ≥ 6.6 ms, ulnar ≥ 6.7 ms ≥ 7.6 ms peroneal, tibial ≥&#xD;
             8.8 ms) + 1 ≥ another parameter * demyelination in ≥ 1 other nerve.&#xD;
&#xD;
        Inclusion criteria for patients NMMBC:&#xD;
&#xD;
          -  Patients with certain NMMBC according to the following criteria defined by the EFNS&#xD;
             (2010):&#xD;
&#xD;
               -  Weak slowly progressive or progressive members in spurts, and focal asymmetric,&#xD;
                  due to damage of the driving motor nerve distribution in at least two nerves, for&#xD;
                  over a month.&#xD;
&#xD;
               -  Lack of objective sensory abnormality except for sensory anomalies minor&#xD;
                  vibrations in the lower limbs.&#xD;
&#xD;
               -  In a nerve:&#xD;
&#xD;
          -  conduction block some engine.&#xD;
&#xD;
          -  Conduction normal sensory nerves in the segments of the upper limbs with conduction&#xD;
             block.&#xD;
&#xD;
               -  No evidence of upper motor neuron.&#xD;
&#xD;
               -  Lack of significant bulbar weakness.&#xD;
&#xD;
               -  Sensory impairment less marked than the minor loss of sensitivity to vibrations&#xD;
                  in the lower limbs.&#xD;
&#xD;
               -  symmetrical weakness Lack broadcasts during the first weeks.&#xD;
&#xD;
        Inclusion criteria for the neuropathy patients with anti-MAG antibody:&#xD;
&#xD;
        - Patients with neuropathy with anti-MAG antibody according to criteria defined by the EFNS&#xD;
        (2010):&#xD;
&#xD;
          -  electrophysiological criteria:&#xD;
&#xD;
               -  symmetrical uniform reduction of conduction velocity; more severe at that sensory&#xD;
                  motor.&#xD;
&#xD;
               -  Distal Motor Latency disproportionately long: Index of Distal Latency ≤ 0.25.&#xD;
&#xD;
               -  Potential sural missing.&#xD;
&#xD;
          -  Clinical criteria:&#xD;
&#xD;
               -  Early disease&gt; 50 years.&#xD;
&#xD;
               -  ataxia associated with shaky hands.&#xD;
&#xD;
          -  Biological criteria:&#xD;
&#xD;
               -  IgM monoclonal rate lower than 10 g / l, or greater than 10 g / l in the context&#xD;
                  of Waldenström's macroglobulinemia.&#xD;
&#xD;
               -  Presence of anti-MAG antibody (Myelin-Associated Glycoprotein).&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Presence of risk factors associated neuropathic disease (diabetes, chronic alcoholism,&#xD;
             kidney failure, HIV status, Lyme disease, vasculitis or any other factor which, in the&#xD;
             judgment of the investigator, could pose a risk).&#xD;
&#xD;
          -  A patient pathology judged by the investigator as interfering with the proper conduct&#xD;
             of the study.&#xD;
&#xD;
          -  Positive pregnancy test. A urine pregnancy test will be performed for women of&#xD;
             childbearing age. Results will be communicated to the patient by a doctor of his&#xD;
             choice.&#xD;
&#xD;
          -  Refusal of the subject to participate in the study.&#xD;
&#xD;
          -  Topic guardianship or curatorship.&#xD;
&#xD;
          -  Inability of the subject to cooperate.&#xD;
&#xD;
          -  No affiliation to a social security scheme (beneficiary or assignee).&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>CHU de Nice</name>
      <address>
        <city>Nice</city>
        <zip>06000</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>France</country>
  </location_countries>
  <verification_date>May 2022</verification_date>
  <study_first_submitted>November 9, 2016</study_first_submitted>
  <study_first_submitted_qc>December 30, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 2, 2017</study_first_posted>
  <last_update_submitted>May 5, 2022</last_update_submitted>
  <last_update_submitted_qc>May 5, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">May 6, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Polyneuropathies</mesh_term>
    <mesh_term>Polyradiculoneuropathy</mesh_term>
    <mesh_term>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03008733
org study id: 16-AOIP-02
nct id: NCT03008733
lead sponsor: 
has dmc: No
is fda regulated drug: No
is fda regulated device: No
The use of nerve ultrasound for the diagnosis and monitoring of neuromuscular diseases is a
      promising growing field (1). Non-invasive and painless, ultrasound provides additional data
      electroneuromyography (EMG), with a spatial resolution at least as good as MRI, while being
      easily accessible and inexpensive.The polyradiculoneuritis Inflammatory Demyelinating
      Chronicles (IPDC), Neuropathies Motrices in Multifocal Conduction Blocks (NMMBC) and
      neuropathy associated with anti-MAG antibodies are among the major chronic inflammatory
      neuropathies with an autoimmune etiology. The diagnosis of these pathologies is based on the
      clinic, diagnostic tests and EMG. The interest not only in the diagnosis, but also for
      monitoring these pathologies using ultrasound analysis nerves has been demonstrated recently
      in several studies. However the limited resolution of current ultrasound images do not allow
      detailed study of the internal structure of the nerves which could later help deepen
      knowledge in this innovative field and can better understand the pathophysiological mechanism
      of the evolution of these pathologies .

      To do this, the investigators have available a UHF ultrasound in the ultrasound department of
      the Nice University Hospital Pasteur Hospital 2 The investigators realize a descriptive
      analysis study, pilot, mono-centric, multi and prospective on patients followed in the center
      with a diagnosis of IPDC, a NMMBC or neuropathy with anti-MAG antibodies and control subjects
      matched by age and sex. All the patients and controls in this study will receive a briefing
      and must sign an informed consent.

      They realize an ultrasound study of the nerve, using an ultra high frequency ultrasound
      system that will allow the assessment of anatomical structures of nerve (size, structure,
      vascularisation and assessment booklets). Ultrasound data will, in a second stage, compared
      with the data obtained with the EMG and clinical scores obtained using clinical rating
      scales. 40 subjects will be included, divided into four subgroups: 10 subjects with a
      diagnosis of IPDC (1), 10 subjects with a diagnosis of NMMBC (2), 10 subjects with a
      diagnosis of neuropathy antibody-anti MAG (3) and 10 control subjects with no signs of
      neuropathy at the EMG examination.
The use of nerve ultrasound for the diagnosis and monitoring of neuromuscular diseases is a
      promising growing field (1). Non-invasive and painless, ultrasound provides additional data
      electroneuromyography (EMG), with a spatial resolution at least as good as MRI, while being
      easily accessible and inexpensive.The polyradiculoneuritis Inflammatory Demyelinating
      Chronicles (IPDC), Neuropathies Motrices in Multifocal Conduction Blocks (NMMBC) and
      neuropathy associated with anti-MAG antibodies are among the major chronic inflammatory
      neuropathies with an autoimmune etiology. The diagnosis of these pathologies is based on the
      clinic, diagnostic tests and EMG. The interest not only in the diagnosis, but also for
      monitoring these pathologies using ultrasound analysis nerves has been demonstrated recently
      in several studies. However the limited resolution of current ultrasound images do not allow
      detailed study of the internal structure of the nerves which could later help deepen
      knowledge in this innovative field and can better understand the pathophysiological mechanism
      of the evolution of these pathologies .

      To do this, the investigators have available a UHF ultrasound in the ultrasound department of
      the Nice University Hospital Pasteur Hospital 2 The investigators realize a descriptive
      analysis study, pilot, mono-centric, multi and prospective on patients followed in the center
      with a diagnosis of IPDC, a NMMBC or neuropathy with anti-MAG antibodies and control subjects
      matched by age and sex. All the patients and controls in this study will receive a briefing
      and must sign an informed consent.

      They realize an ultrasound study of the nerve, using an ultra high frequency ultrasound
      system that will allow the assessment of anatomical structures of nerve (size, structure,
      vascularisation and assessment booklets). Ultrasound data will, in a second stage, compared
      with the data obtained with the EMG and clinical scores obtained using clinical rating
      scales. 40 subjects will be included, divided into four subgroups: 10 subjects with a
      diagnosis of IPDC (1), 10 subjects with a diagnosis of NMMBC (2), 10 subjects with a
      diagnosis of neuropathy antibody-anti MAG (3) and 10 control subjects with no signs of
      neuropathy at the EMG examination.

      The main objective of this pilot study is to provide a descriptive analysis of the morphology
      of the nerves with an ultra high frequency ultrasound in subgroups of CIDP patients, anti-MAG
      antibodies and neuropathy NMMBC and controls. The thickness of the epineurium, the hallmarks
      of fascicular organization, Doppler vascularity, the nerve-sectional area, the specification
      of the section surface, nerve hypertrophy, the thickness of the perineurium and
      ultrastructural characterization of the different fascicular organization typologies will be
      well analyzed in order to better understand the specific sonographic characteristics of each
      disease compared with controls, no data exist at present in the literature with such image
      resolution.

      Secondary objectives:

        1. Compare the morphological characteristics obtained by ultra high frequency ultrasound
           between different subjects subgroups according to the morphological data collected and
           sonographic scores: evaluation of nerve hypertrophy (intra- and inter-ratio nerve nerve)
           (4 ) and intra-fascicular nerve and nerve cross-ratio.

        2. To study the correlation between sonographic and clinical scores scores in different
           subjects subgroups using functional assessment scales: MRC score, R-ODS score, INCAT,
           ONLS, ataxia Score and a torque rating of grip strength.

        3. To study the correlation between sonographic scores and electrophysiological scores by
           making a électroneurogramme (ENG) in the different subjects of subgroups: the amplitude
           and distal motor latency for distal motor conduction, the motor conduction velocities,
           the presence of time dispersion or of a conduction block to the stepped motor
           conduction, the latency of the waveform F to the proximal motor conduction and the
           amplitude of the sensory potential for sensory conduction.
allocation: Non-Randomized
intervention model: Parallel Assignment
primary purpose: Basic Science
masking: None (Open Label)
measure: morphology of the nerves by means of an ultra-high frequency ultrasound in patients subgroups CIDP, anti-MAG antibodies and NMMBC neuropathy and control subjects.
time frame: through study completion an average of 3 years
arm group label: NMMCB
arm group type: Active Comparator
description: patient with Neuropathies with Motrices Multifocal Conduction Block
arm group label: PICD
arm group type: Active Comparator
description: patient with Inflammatory demyelinating polyneuropathy Chronicle
arm group label: anti MAG
arm group type: Active Comparator
description: patient with neuropathy antibody Anti-MAG
arm group label: healthy
arm group type: Placebo Comparator
description: healthy patient
intervention type: Other
intervention name: Ultrasound UHF peripheral nerves
description: Ultrasound UHF peripheral nerves
arm group label: NMMCB
arm group label: PICD
arm group label: anti MAG
arm group label: healthy
intervention type: Other
intervention name: Electro myography surface nerves
description: Electro myography surface nerves
arm group label: NMMCB
arm group label: PICD
arm group label: anti MAG
arm group label: healthy
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
facility: 
country: France
responsible party type: Sponsor
mesh term: Polyneuropathies
mesh term: Polyradiculoneuropathy
mesh term: Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
sharing ipd: No