<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03020186</url>
  </required_header>
  <id_info>
    <org_study_id>BGU</org_study_id>
    <nct_id>NCT03020186</nct_id>
  </id_info>
  <brief_title>Effects of Green-MED Diet Via the Gut-fat-brain Axis</brief_title>
  <acronym>DIRECT-PLUS</acronym>
  <official_title>Effects of Green-MED Diet Via the Gut-fat-brain Axis; DIRECT-PLUS</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Ben-Gurion University of the Negev</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Harvard School of Public Health (HSPH)</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>University of Leipzig</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Ben-Gurion University of the Negev</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      Mediterranean (MED) diet, richer in plants/seeds (and dietary polyphenols) and low in&#xD;
      processed meat (green-MED diet) may have a pronounced beneficial effect on age-related&#xD;
      declines that begin in middle age, reflected by changes in adiposity, cognitive function, and&#xD;
      cardiometabolic risk. The investigators hypothesize that long-term intake of this diet will&#xD;
      significantly potentiate the effects of a healthy lifestyle (physical activity and&#xD;
      Mediterranean diet), constituting a powerful strategy to halt or even reverse the progression&#xD;
      of several age-related processes related to adiposity, cardiometabolic health and cognition.&#xD;
      The investigators further hypothesize that lifestyle intervention might modify the gut&#xD;
      microbiota profile and that autologous fecal microbiota supplement derived from the time of&#xD;
      maximal weight loss might halt the expected subsequent regain phase.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The investigators aim to compare the effect of green-MED diet+ physical activity (PA) vs. MED&#xD;
      diet+ PA vs. PA on the gut-fat-brain axis and to explore the additional contribution of&#xD;
      autologous fecal microbiota derived at the rapid weight loss phase on regain phase.&#xD;
      Mediterranean (MED) diet, richer in plants/seeds (and dietary polyphenols) and low in&#xD;
      processed meat may have a pronounced beneficial effect on age-related declines that begin in&#xD;
      middle age, reflected by changes in adiposity, cognitive function, and cardiometabolic risk.&#xD;
      The investigators hypothesize that long-term intake of this diet will significantly&#xD;
      potentiate the effects of a healthy lifestyle (physical activity and Mediterranean diet),&#xD;
      constituting a powerful strategy to halt or even reverse the progression of several&#xD;
      age-related processes related to adiposity, cardiometabolic health and cognition. The&#xD;
      investigators further hypothesize that lifestyle intervention might modify the gut microbiota&#xD;
      profile and that autologous fecal microbiota supplement derived from the time of maximal&#xD;
      weight loss might halt the expected subsequent regain phase. The investigators will follow&#xD;
      the participants with magnetic resonance imaging (MRI) that will include abdominal and&#xD;
      hepatic fat, cardiac and anatomic/functional brain assessments. The investigators will&#xD;
      perform cognitive tests and will measure changes in gut microbiota and sub-metabolomic&#xD;
      profiling. The trial will be performed in an isolated workplace (the Nuclear Research Center)&#xD;
      which holds an exclusive cafeteria that provides free, dietary -monitored, lunch, and an&#xD;
      internal medical department. The exclusive nutritional profile of walnuts, with its relative&#xD;
      high polyphenols content and unique composition, may benefit several health outcomes.&#xD;
      Epidemiologic studies and RCTs suggest that walnuts consumption is associated with better&#xD;
      weight status, adiposity measures and cardiometabolic state. However, some individuals avoid&#xD;
      walnuts because they are calorie-dense, and fear that they will promote weight gain. Walnuts&#xD;
      contain numerous well-characterized beneficial nutritional components, such as unsaturated&#xD;
      fats, especially omega-3 fatty acids, dietary fibers, and high levels of vitamins and&#xD;
      minerals. Among other well-recognized components, nuts are highly rich in polyphenols, mainly&#xD;
      flavonoids. Polyphenols may potentially interact with physical activity and promote&#xD;
      neurogenesis; a process that may significantly contribute to the brain's ageing process.&#xD;
      Similarly, the polyphenol epigallocatechin-3-gallate (EGCG, a type of catechin found in green&#xD;
      tea), was proposed to exert neuroprotective effects. New specific developed strain of&#xD;
      duckweed [Wolffia globose, &quot;Mankai&quot;] , an aquatic plant, which might serve as a protein&#xD;
      source and contains all the 9 essential and the 6 conditional amino acids. &quot;Mankai&quot;&#xD;
      [(Generally recognized as safe (GRAS)] is a cultivated strain of Wolffia globosa, which is an&#xD;
      aquatic plant, part of the family of plants known commonly as duckweeds. Duckweeds are very&#xD;
      simple flowering aquatic plants, which float on or just beneath the surface of still or&#xD;
      slow-moving bodies of water. There is a long history of the use of Wolffia species, in&#xD;
      particular Wolffia Globosa, as food, especially in Southeast Asia: Burma, Laos and northern&#xD;
      Thailand, where it has been used as a vegetable for many generations. The nutritional&#xD;
      composition of &quot;Mankai&quot; has been determined and found to be high in protein, containing all&#xD;
      the essential and conditionally essential amino acids, dietary fibers and several vitamins&#xD;
      and minerals.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">January 2017</start_date>
  <completion_date type="Actual">March 2019</completion_date>
  <primary_completion_date type="Actual">March 2019</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Prevention</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Abdominal fat</measure>
    <time_frame>18 months</time_frame>
    <description>Changes in visceral fat (MRI)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Hepatic fat</measure>
    <time_frame>18 months</time_frame>
    <description>Changes in hepatic fat (MRI)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Obesity</measure>
    <time_frame>6, 14, 18 months</time_frame>
    <description>Changes in body weight and waist circumference</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Brain anatomy</measure>
    <time_frame>18 months</time_frame>
    <description>Changes in hippocampus volume, diffusion Tensor Imaging (MRI)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cognitive function-MRI</measure>
    <time_frame>18 months</time_frame>
    <description>Changes in resting state connectivity (MRI, sub-study)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cognitive function</measure>
    <time_frame>18 months</time_frame>
    <description>cognitive tests</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cardiac state</measure>
    <time_frame>18 months</time_frame>
    <description>Changes in cardiac anatomy (MRI, substudy)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cardiac state</measure>
    <time_frame>18 months</time_frame>
    <description>Changes in cardiac function (MRI, substudy)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Endothelial dysfunction</measure>
    <time_frame>18 months</time_frame>
    <description>Changes endothelial function (ECG)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Lipid profile</measure>
    <time_frame>6 , 14 and 18 months</time_frame>
    <description>Changes in lipid biomarkers (blood draw)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Glycemic control</measure>
    <time_frame>6 , 14 and 18 months</time_frame>
    <description>Changes in glycemic biomarkers (blood draw)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Inflammatory state</measure>
    <time_frame>6 , 14 and 18 months</time_frame>
    <description>Changes in inflammatory biomarkers (blood draw)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Metabolomic</measure>
    <time_frame>18 months</time_frame>
    <description>Changes in sub-lipids (blood draw)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Metabolomic</measure>
    <time_frame>18 months</time_frame>
    <description>Changes in sub-proteins ( blood draw)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Liver function (blood biomarkers)</measure>
    <time_frame>6 and 18 months</time_frame>
    <description>Changes in liver function biomarkers (blood draw)</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Genetic signature</measure>
    <time_frame>baseline</time_frame>
    <description>SNPs associated with fat distribution and visceral fat</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Epigenetics</measure>
    <time_frame>18 months</time_frame>
    <description>changes in mRNAs</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Epigenetics</measure>
    <time_frame>18 months</time_frame>
    <description>changes in genes' methylation</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Well being</measure>
    <time_frame>18 months</time_frame>
    <description>assessed by questionnaire</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Fecal microbiota profile</measure>
    <time_frame>6, 14, 18 months</time_frame>
    <description>Diversity Index as a key measure</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>24h- continuous glucose levels</measure>
    <time_frame>2 weeks</time_frame>
    <description>24h dynamics of glucose using continuous glucose monitor. substudy</description>
  </secondary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Actual">294</enrollment>
  <condition>Abdominal Obesity Metabolic Syndrome</condition>
  <arm_group>
    <arm_group_label>Physical activity</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Physical activity (PA) group will receive free gym memberships and the instruction necessary to engage in moderate-intensity physical activity, ~80% of which will have an aerobic component. The participants will get basic health promoting guideline for healthy diet .</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Physical activity+ MED diet</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>On top of the PA intervention described in Arm 1, the participants will be guided for moderate weight loss with a traditional Mediterranean (MED) diet, low in simple carbohydrates. The diet will include 1oz/day of walnuts that will be provided free of charge.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Physical activity+ green-MED diet</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>On top of the PA intervention described in Arm 1, the participants will guided for moderate weight loss with a MED diet, low in simple carbohydrates that will be rich in plants and polyphenols and low in processed meat. The diet will include 1oz/day of walnuts, 3-4 cups/day of green tea and ~500cc green shake/dinner based on specific strain of duckweed [Wolffia globose, &quot;Mankai&quot;], an aquatic plant, which might serve as a plant protein source. All the above will be provided free of charge.</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Physical activity</intervention_name>
    <arm_group_label>Physical activity</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Physical activity+ MED diet</intervention_name>
    <arm_group_label>Physical activity+ MED diet</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Physical activity+green MED diet</intervention_name>
    <description>****Sub-study from all 3 main arms: Autologous fecal microbiota supplement intervention derived from the time of maximal weight loss: At the 6-month time period, the time of anticipated greatest weight reduction, participants's feces samples will be processed to capsulized inocula. Samples will be frozen within 2 hours and will be kept at -80c pending analysis. Participants will be randomized to receive either research capsules or identical placebo capsules between 8 and 14 months time period. Placebo capsules will consist of a combination of powdered cocoa and vegetable gelatin in normal saline/glycerol and will be identical in appearance to research capsules.</description>
    <arm_group_label>Physical activity+ green-MED diet</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
        age &gt;30 years with abdominal adiposity (waist circumference: men &gt; 102 cm, women &gt; 88 cm)&#xD;
        or dyslipidemia (TG&gt;150mg/dl and HDL-c &lt;40mg/dL for men and &lt;50mg/dL for women)&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
        Individuals who may not be able to partake in PA in the gym; TGs&gt;400 mg/dL; serum&#xD;
        creatinine&gt;2 mg/dL; disturbed liver function; major illness that might require&#xD;
        hospitalization; pregnant or lactating women; presence of active cancer, is receiving or&#xD;
        received chemotherapy in the last three years; participation in another trial; participants&#xD;
        who are treated with Coumadin (warfarin) - given its interaction with vitamin K and high&#xD;
        level of this vitamin in &quot;Mankai&quot; green shake; pacemaker or platinum implant, because of&#xD;
        the impossibility of MRI screening.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>30 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Iris Shai, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Ben-Gurion University of the Negev</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Nuclear research center Negev</name>
      <address>
        <city>Dimona</city>
        <country>Israel</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Israel</country>
  </location_countries>
  <verification_date>January 2017</verification_date>
  <study_first_submitted>January 9, 2017</study_first_submitted>
  <study_first_submitted_qc>January 11, 2017</study_first_submitted_qc>
  <study_first_posted type="Estimate">January 13, 2017</study_first_posted>
  <last_update_submitted>July 11, 2019</last_update_submitted>
  <last_update_submitted_qc>July 11, 2019</last_update_submitted_qc>
  <last_update_posted type="Actual">July 15, 2019</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Ben-Gurion University of the Negev</investigator_affiliation>
    <investigator_full_name>Iris Shai</investigator_full_name>
    <investigator_title>Principle investigator</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Metabolic Syndrome</mesh_term>
    <mesh_term>Obesity, Abdominal</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03020186
org study id: BGU
nct id: NCT03020186
lead sponsor: 
collaborator: 
collaborator: 
has dmc: Yes
Mediterranean (MED) diet, richer in plants/seeds (and dietary polyphenols) and low in
      processed meat (green-MED diet) may have a pronounced beneficial effect on age-related
      declines that begin in middle age, reflected by changes in adiposity, cognitive function, and
      cardiometabolic risk. The investigators hypothesize that long-term intake of this diet will
      significantly potentiate the effects of a healthy lifestyle (physical activity and
      Mediterranean diet), constituting a powerful strategy to halt or even reverse the progression
      of several age-related processes related to adiposity, cardiometabolic health and cognition.
      The investigators further hypothesize that lifestyle intervention might modify the gut
      microbiota profile and that autologous fecal microbiota supplement derived from the time of
      maximal weight loss might halt the expected subsequent regain phase.
The investigators aim to compare the effect of green-MED diet+ physical activity (PA) vs. MED
      diet+ PA vs. PA on the gut-fat-brain axis and to explore the additional contribution of
      autologous fecal microbiota derived at the rapid weight loss phase on regain phase.
      Mediterranean (MED) diet, richer in plants/seeds (and dietary polyphenols) and low in
      processed meat may have a pronounced beneficial effect on age-related declines that begin in
      middle age, reflected by changes in adiposity, cognitive function, and cardiometabolic risk.
      The investigators hypothesize that long-term intake of this diet will significantly
      potentiate the effects of a healthy lifestyle (physical activity and Mediterranean diet),
      constituting a powerful strategy to halt or even reverse the progression of several
      age-related processes related to adiposity, cardiometabolic health and cognition. The
      investigators further hypothesize that lifestyle intervention might modify the gut microbiota
      profile and that autologous fecal microbiota supplement derived from the time of maximal
      weight loss might halt the expected subsequent regain phase. The investigators will follow
      the participants with magnetic resonance imaging (MRI) that will include abdominal and
      hepatic fat, cardiac and anatomic/functional brain assessments. The investigators will
      perform cognitive tests and will measure changes in gut microbiota and sub-metabolomic
      profiling. The trial will be performed in an isolated workplace (the Nuclear Research Center)
      which holds an exclusive cafeteria that provides free, dietary -monitored, lunch, and an
      internal medical department. The exclusive nutritional profile of walnuts, with its relative
      high polyphenols content and unique composition, may benefit several health outcomes.
      Epidemiologic studies and RCTs suggest that walnuts consumption is associated with better
      weight status, adiposity measures and cardiometabolic state. However, some individuals avoid
      walnuts because they are calorie-dense, and fear that they will promote weight gain. Walnuts
      contain numerous well-characterized beneficial nutritional components, such as unsaturated
      fats, especially omega-3 fatty acids, dietary fibers, and high levels of vitamins and
      minerals. Among other well-recognized components, nuts are highly rich in polyphenols, mainly
      flavonoids. Polyphenols may potentially interact with physical activity and promote
      neurogenesis; a process that may significantly contribute to the brain's ageing process.
      Similarly, the polyphenol epigallocatechin-3-gallate (EGCG, a type of catechin found in green
      tea), was proposed to exert neuroprotective effects. New specific developed strain of
      duckweed [Wolffia globose, "Mankai"] , an aquatic plant, which might serve as a protein
      source and contains all the 9 essential and the 6 conditional amino acids. "Mankai"
      [(Generally recognized as safe (GRAS)] is a cultivated strain of Wolffia globosa, which is an
      aquatic plant, part of the family of plants known commonly as duckweeds. Duckweeds are very
      simple flowering aquatic plants, which float on or just beneath the surface of still or
      slow-moving bodies of water. There is a long history of the use of Wolffia species, in
      particular Wolffia Globosa, as food, especially in Southeast Asia: Burma, Laos and northern
      Thailand, where it has been used as a vegetable for many generations. The nutritional
      composition of "Mankai" has been determined and found to be high in protein, containing all
      the essential and conditionally essential amino acids, dietary fibers and several vitamins
      and minerals.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Prevention
masking: None (Open Label)
measure: Abdominal fat
time frame: 18 months
description: Changes in visceral fat (MRI)
measure: Hepatic fat
time frame: 18 months
description: Changes in hepatic fat (MRI)
measure: Obesity
time frame: 6, 14, 18 months
description: Changes in body weight and waist circumference
measure: Brain anatomy
time frame: 18 months
description: Changes in hippocampus volume, diffusion Tensor Imaging (MRI)
measure: Cognitive function-MRI
time frame: 18 months
description: Changes in resting state connectivity (MRI, sub-study)
measure: Cognitive function
time frame: 18 months
description: cognitive tests
measure: Cardiac state
time frame: 18 months
description: Changes in cardiac anatomy (MRI, substudy)
measure: Cardiac state
time frame: 18 months
description: Changes in cardiac function (MRI, substudy)
measure: Endothelial dysfunction
time frame: 18 months
description: Changes endothelial function (ECG)
measure: Lipid profile
time frame: 6 , 14 and 18 months
description: Changes in lipid biomarkers (blood draw)
measure: Glycemic control
time frame: 6 , 14 and 18 months
description: Changes in glycemic biomarkers (blood draw)
measure: Inflammatory state
time frame: 6 , 14 and 18 months
description: Changes in inflammatory biomarkers (blood draw)
measure: Metabolomic
time frame: 18 months
description: Changes in sub-lipids (blood draw)
measure: Metabolomic
time frame: 18 months
description: Changes in sub-proteins ( blood draw)
measure: Liver function (blood biomarkers)
time frame: 6 and 18 months
description: Changes in liver function biomarkers (blood draw)
measure: Genetic signature
time frame: baseline
description: SNPs associated with fat distribution and visceral fat
measure: Epigenetics
time frame: 18 months
description: changes in mRNAs
measure: Epigenetics
time frame: 18 months
description: changes in genes' methylation
measure: Well being
time frame: 18 months
description: assessed by questionnaire
measure: Fecal microbiota profile
time frame: 6, 14, 18 months
description: Diversity Index as a key measure
measure: 24h- continuous glucose levels
time frame: 2 weeks
description: 24h dynamics of glucose using continuous glucose monitor. substudy
arm group label: Physical activity
arm group type: Placebo Comparator
description: Physical activity (PA) group will receive free gym memberships and the instruction necessary to engage in moderate-intensity physical activity, ~80% of which will have an aerobic component. The participants will get basic health promoting guideline for healthy diet .
arm group label: Physical activity+ MED diet
arm group type: Experimental
description: On top of the PA intervention described in Arm 1, the participants will be guided for moderate weight loss with a traditional Mediterranean (MED) diet, low in simple carbohydrates. The diet will include 1oz/day of walnuts that will be provided free of charge.
arm group label: Physical activity+ green-MED diet
arm group type: Experimental
description: On top of the PA intervention described in Arm 1, the participants will guided for moderate weight loss with a MED diet, low in simple carbohydrates that will be rich in plants and polyphenols and low in processed meat. The diet will include 1oz/day of walnuts, 3-4 cups/day of green tea and ~500cc green shake/dinner based on specific strain of duckweed [Wolffia globose, "Mankai"], an aquatic plant, which might serve as a plant protein source. All the above will be provided free of charge.
intervention type: Other
intervention name: Physical activity
arm group label: Physical activity
intervention type: Other
intervention name: Physical activity+ MED diet
arm group label: Physical activity+ MED diet
intervention type: Other
intervention name: Physical activity+green MED diet
description: ****Sub-study from all 3 main arms: Autologous fecal microbiota supplement intervention derived from the time of maximal weight loss: At the 6-month time period, the time of anticipated greatest weight reduction, participants's feces samples will be processed to capsulized inocula. Samples will be frozen within 2 hours and will be kept at -80c pending analysis. Participants will be randomized to receive either research capsules or identical placebo capsules between 8 and 14 months time period. Placebo capsules will consist of a combination of powdered cocoa and vegetable gelatin in normal saline/glycerol and will be identical in appearance to research capsules.
arm group label: Physical activity+ green-MED diet
criteria: 
gender: All
minimum age: 30 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
last name: Iris Shai, PhD
role: Principal Investigator
affiliation: Ben-Gurion University of the Negev
facility: 
country: Israel
responsible party type: Principal Investigator
investigator affiliation: Ben-Gurion University of the Negev
investigator full name: Iris Shai
investigator title: Principle investigator
mesh term: Metabolic Syndrome
mesh term: Obesity, Abdominal
sharing ipd: No