<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02980094</url>
  </required_header>
  <id_info>
    <org_study_id>4921/2011</org_study_id>
    <nct_id>NCT02980094</nct_id>
  </id_info>
  <brief_title>Milk Biofortification Promotes Health Benefits in Institutionalized Elderly</brief_title>
  <official_title>Effects of Inclusion of Sunflower Oil, Vitamin E and Selenium in the Diet of Dairy Cows on Milk Composition and Its Influence on Nutrition and Health of Elderly</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Eduardo Ferriolli</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>University of Sao Paulo</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The project aims to study the effects of inclusion of sunflower oil, vitamin E and selenium&#xD;
      in the diet of dairy cows on milk composition and the influence of modified milk on nutrition&#xD;
      and health of elderly. To achieve those goals, two experiments will be conducted, both&#xD;
      lasting 12 weeks. In the first one, 32 cows at the beginning of lactation will be allotted in&#xD;
      a completely randomized block design with a 2 x 2 factorial arrangement of treatments, as&#xD;
      follow: 1) control diet; 2) control diet plus selenium and vitamin E; 3) control diet plus&#xD;
      sunflower oil diet; 4) control diet plus sunflower oil, selenium and vitamin E. This&#xD;
      experiment seeks the development of modified milks through nutritional manipulation of cow's&#xD;
      diet. Concomitantly, in the second experiment, 132 elderly people will receive the four&#xD;
      different kinds of milk produced in the first experiment in a completely randomized block&#xD;
      (gender) design. The selection of the elderly for each group shall be composed clinical&#xD;
      evaluations. Will be conducted biochemical tests before and after supplementation of milk&#xD;
      consumption (serum α-tocopherol, selenium, analysis of fatty acid profile). Assessment of&#xD;
      nutritional status will be made body mass index (BMI) with each participant before and after&#xD;
      the experiment of 12 weeks, including body composition by multifrequency bioelectrical&#xD;
      impedance analysis (BIA), evaluating the strength of pressure of the hand portable&#xD;
      dynamometer, demographics and food consumption. The study of human nutrition and health will&#xD;
      be held in the form of a double-blind study. The second experiment aims to study nutrition&#xD;
      and health of elderly people, as it is expected that milk produced with better fatty acid&#xD;
      profile, vitamin and minerals can improve the inflammatory profile of markers of the elderly.&#xD;
      This project is important for the human population in general, particularly elderly people,&#xD;
      health workers, human and animal nutritionists, and especially for the milk chain, as it has&#xD;
      a potential to develop new dairy products and boost milk consumption.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Completed</overall_status>
  <start_date>August 2011</start_date>
  <completion_date type="Actual">December 2011</completion_date>
  <primary_completion_date type="Actual">September 2011</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Other</primary_purpose>
    <masking>Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Change in serum α-tocopherol</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Assessment by blood sampling. Collect of α-tocopherol before and after to 12 weeks of milk supplementation</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Change in serum selenium</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Assessment by blood sampling. Collect of selenium before and after to 12 weeks milk supplementation</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Change in analysis of fatty acid profile</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Assessment by blood sampling. Collect of analysis of fatty acid profile before and after to 12 weeks of milk supplementation</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Assessment of nutritional status: food intake questionnaire</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Food consumption questionnaire during the milk supplementation</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in handgrip strength</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Measure of the hand grip strength using a portable dynamometer before and after 12 weeks of milk supplementation</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Assessment of nutritional status: anthropometry (BMI)</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>BMI before and after 12 weeks of milk supplementation</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Assessment of nutritional status: body composition</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Body composition measured by multifrequency bioelectrical impedance analysis (BIA) before and after to 12 week of milk supplementation</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Assessment demographics: questionnaire</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Demographics questionnaire applied during the milk supplementation</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Change in profile of Inflammatory markers</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Serum Cytokines measured in blood sample before and after to 12 weeks of milk supplementation</description>
  </other_outcome>
  <other_outcome>
    <measure>Change in gene expression</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Gene expression of cyclooxygenase -1 (COX-1) e-2, monocyte chemotactic protein (MCP-1), peroxisome proliferator-activated receptor (PPAR) (-δ, -α and -β / δ) measured in blood sample before and after to 12 weeks milk supplementation</description>
  </other_outcome>
  <other_outcome>
    <measure>Change in production of reactive oxygen species</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Production of reactive oxygen species (ROS) produced by stimulated neutrophils measured in blood sample before and after to 12 weeks milk supplementation</description>
  </other_outcome>
  <other_outcome>
    <measure>Change in phagocytic activity</measure>
    <time_frame>before and after 12 weeks</time_frame>
    <description>Phagocytic activity measured in blood sample before and after to 12 weeks milk supplementation</description>
  </other_outcome>
  <number_of_arms>4</number_of_arms>
  <enrollment type="Actual">132</enrollment>
  <condition>Nutrient Deficiency</condition>
  <condition>Age-Related Immunodeficiency</condition>
  <condition>Vitamin E Deficiency</condition>
  <condition>Selenium Deficiency</condition>
  <condition>Fatty Acid Deficiency</condition>
  <condition>Institutionalization; Disinhibited Attachment</condition>
  <arm_group>
    <arm_group_label>Milk Control group(C)</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Using a randomized block design, 25 institutionalized elderly to receive the milk 3 times per day produced by lactating cows fed with the following diet, one of the group is control (C), without vitamin E, selenium, sunflower oil in the cow's food.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Milk Antioxidant group(A)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Using a randomized block design, 25 institutionalized elderly to receive the milk produced by lactating cows fed with the following diet: control (C) +vitamin E+ selenium (A).</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Milk Oil group(O)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Using a randomized block design, 25 institutionalized elderly to receive the milk produced by lactating cows fed with the following diets: control (C)+sunflower oil (O).</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Milk Antioxidant and oil(AO)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Using a randomized block design, 25 institutionalized elderly to receive the milk produced by lactating cows fed with the following diets: control C+sunflower oil+vitamin E+selenium (AO) .</description>
  </arm_group>
  <intervention>
    <intervention_type>Dietary Supplement</intervention_type>
    <intervention_name>Milk Antioxidant group(A)</intervention_name>
    <description>There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets: control (C)+selenium and vitamin E (A).</description>
    <arm_group_label>Milk Antioxidant group(A)</arm_group_label>
    <other_name>add control diet(C) in the cow's food</other_name>
    <other_name>add selenium in the cow's food</other_name>
    <other_name>add vitamin E in the cow's food</other_name>
  </intervention>
  <intervention>
    <intervention_type>Dietary Supplement</intervention_type>
    <intervention_name>Milk Oil group(O)</intervention_name>
    <description>There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets: control (C)+sunflower oil (O).</description>
    <arm_group_label>Milk Oil group(O)</arm_group_label>
    <other_name>add control diet(C) in the cow's food</other_name>
    <other_name>add sunflower oil group in the cow's food</other_name>
  </intervention>
  <intervention>
    <intervention_type>Dietary Supplement</intervention_type>
    <intervention_name>Milk Antioxidant and oil(AO)</intervention_name>
    <description>There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets:control (C)+selenium, vitamin E and sunflower oil (AO).</description>
    <arm_group_label>Milk Antioxidant and oil(AO)</arm_group_label>
    <other_name>add control diet(C) in the cow's food</other_name>
    <other_name>add selenium in the cow's food</other_name>
    <other_name>add vitamin E in the cow's food</other_name>
    <other_name>add sunflower oil in the cow's food</other_name>
  </intervention>
  <intervention>
    <intervention_type>Dietary Supplement</intervention_type>
    <intervention_name>Milk Control group(C)</intervention_name>
    <description>There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets: control (C)</description>
    <arm_group_label>Milk Control group(C)</arm_group_label>
    <other_name>add control diet (C) in the cow's food</other_name>
    <other_name>without vitamin E in the cow's food</other_name>
    <other_name>without selenium in the cow's food</other_name>
    <other_name>without sunflower oil in the cow's food</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Any institution residents that use milk in their usual diet.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Inability to drink&#xD;
&#xD;
          -  Use of enteral diets&#xD;
&#xD;
          -  Lactose intolerance&#xD;
&#xD;
          -  Autoimmune disorders&#xD;
&#xD;
          -  Infections, allergies or inflammation in the two weeks prior to blood collection.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>60 Years</minimum_age>
    <maximum_age>110 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Eduardo Ferriolli, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Study Principal Investigator</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Helio Vannucchi, PhD</last_name>
    <role>Study Chair</role>
    <affiliation>Study Chair investigator</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Clinics Hospital of the Ribeirao Preto Medical School</name>
      <address>
        <city>Ribeirão Preto</city>
        <state>São Paulo</state>
        <zip>14048-900</zip>
        <country>Brazil</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Brazil</country>
  </location_countries>
  <results_reference>
    <citation>Barr SI, McCarron DA, Heaney RP, Dawson-Hughes B, Berga SL, Stern JS, Oparil S. Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults. J Am Diet Assoc. 2000 Jul;100(7):810-7. doi: 10.1016/S0002-8223(00)00236-4.</citation>
    <PMID>10916520</PMID>
  </results_reference>
  <results_reference>
    <citation>Bouis HE, Hotz C, McClafferty B, Meenakshi JV, Pfeiffer WH. Biofortification: a new tool to reduce micronutrient malnutrition. Food Nutr Bull. 2011 Mar;32(1 Suppl):S31-40. doi: 10.1177/15648265110321S105.</citation>
    <PMID>21717916</PMID>
  </results_reference>
  <results_reference>
    <citation>Witkowska Z, Michalak I, Korczynski M, Szoltysik M, Swiniarska M, Dobrzanski Z, Tuhy L, Samoraj M, Chojnacka K. Biofortification of milk and cheese with microelements by dietary feed bio-preparations. J Food Sci Technol. 2015 Oct;52(10):6484-92. doi: 10.1007/s13197-014-1696-9. Epub 2015 Jan 21.</citation>
    <PMID>26396393</PMID>
  </results_reference>
  <results_reference>
    <citation>Kratz M, Baars T, Guyenet S. The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease. Eur J Nutr. 2013 Feb;52(1):1-24. doi: 10.1007/s00394-012-0418-1. Epub 2012 Jul 19.</citation>
    <PMID>22810464</PMID>
  </results_reference>
  <verification_date>March 2018</verification_date>
  <study_first_submitted>November 9, 2016</study_first_submitted>
  <study_first_submitted_qc>November 29, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">December 2, 2016</study_first_posted>
  <last_update_submitted>March 28, 2018</last_update_submitted>
  <last_update_submitted_qc>March 28, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">March 30, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>University of Sao Paulo</investigator_affiliation>
    <investigator_full_name>Eduardo Ferriolli</investigator_full_name>
    <investigator_title>Assistant professor</investigator_title>
  </responsible_party>
  <keyword>aging</keyword>
  <keyword>nutrients</keyword>
  <keyword>milk</keyword>
  <keyword>dietary supplementation</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Vitamin E Deficiency</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Vitamins</mesh_term>
    <mesh_term>Vitamin E</mesh_term>
    <mesh_term>Tocopherols</mesh_term>
    <mesh_term>Tocotrienols</mesh_term>
    <mesh_term>alpha-Tocopherol</mesh_term>
    <mesh_term>Selenium</mesh_term>
    <mesh_term>Antioxidants</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02980094
org study id: 4921/2011
nct id: NCT02980094
lead sponsor: 
has dmc: Yes
The project aims to study the effects of inclusion of sunflower oil, vitamin E and selenium
      in the diet of dairy cows on milk composition and the influence of modified milk on nutrition
      and health of elderly. To achieve those goals, two experiments will be conducted, both
      lasting 12 weeks. In the first one, 32 cows at the beginning of lactation will be allotted in
      a completely randomized block design with a 2 x 2 factorial arrangement of treatments, as
      follow: 1) control diet; 2) control diet plus selenium and vitamin E; 3) control diet plus
      sunflower oil diet; 4) control diet plus sunflower oil, selenium and vitamin E. This
      experiment seeks the development of modified milks through nutritional manipulation of cow's
      diet. Concomitantly, in the second experiment, 132 elderly people will receive the four
      different kinds of milk produced in the first experiment in a completely randomized block
      (gender) design. The selection of the elderly for each group shall be composed clinical
      evaluations. Will be conducted biochemical tests before and after supplementation of milk
      consumption (serum α-tocopherol, selenium, analysis of fatty acid profile). Assessment of
      nutritional status will be made body mass index (BMI) with each participant before and after
      the experiment of 12 weeks, including body composition by multifrequency bioelectrical
      impedance analysis (BIA), evaluating the strength of pressure of the hand portable
      dynamometer, demographics and food consumption. The study of human nutrition and health will
      be held in the form of a double-blind study. The second experiment aims to study nutrition
      and health of elderly people, as it is expected that milk produced with better fatty acid
      profile, vitamin and minerals can improve the inflammatory profile of markers of the elderly.
      This project is important for the human population in general, particularly elderly people,
      health workers, human and animal nutritionists, and especially for the milk chain, as it has
      a potential to develop new dairy products and boost milk consumption.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Other
masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
measure: Change in serum α-tocopherol
time frame: before and after 12 weeks
description: Assessment by blood sampling. Collect of α-tocopherol before and after to 12 weeks of milk supplementation
measure: Change in serum selenium
time frame: before and after 12 weeks
description: Assessment by blood sampling. Collect of selenium before and after to 12 weeks milk supplementation
measure: Change in analysis of fatty acid profile
time frame: before and after 12 weeks
description: Assessment by blood sampling. Collect of analysis of fatty acid profile before and after to 12 weeks of milk supplementation
measure: Assessment of nutritional status: food intake questionnaire
time frame: before and after 12 weeks
description: Food consumption questionnaire during the milk supplementation
measure: Change in handgrip strength
time frame: before and after 12 weeks
description: Measure of the hand grip strength using a portable dynamometer before and after 12 weeks of milk supplementation
measure: Assessment of nutritional status: anthropometry (BMI)
time frame: before and after 12 weeks
description: BMI before and after 12 weeks of milk supplementation
measure: Assessment of nutritional status: body composition
time frame: before and after 12 weeks
description: Body composition measured by multifrequency bioelectrical impedance analysis (BIA) before and after to 12 week of milk supplementation
measure: Assessment demographics: questionnaire
time frame: before and after 12 weeks
description: Demographics questionnaire applied during the milk supplementation
measure: Change in profile of Inflammatory markers
time frame: before and after 12 weeks
description: Serum Cytokines measured in blood sample before and after to 12 weeks of milk supplementation
measure: Change in gene expression
time frame: before and after 12 weeks
description: Gene expression of cyclooxygenase -1 (COX-1) e-2, monocyte chemotactic protein (MCP-1), peroxisome proliferator-activated receptor (PPAR) (-δ, -α and -β / δ) measured in blood sample before and after to 12 weeks milk supplementation
measure: Change in production of reactive oxygen species
time frame: before and after 12 weeks
description: Production of reactive oxygen species (ROS) produced by stimulated neutrophils measured in blood sample before and after to 12 weeks milk supplementation
measure: Change in phagocytic activity
time frame: before and after 12 weeks
description: Phagocytic activity measured in blood sample before and after to 12 weeks milk supplementation
arm group label: Milk Control group(C)
arm group type: Placebo Comparator
description: Using a randomized block design, 25 institutionalized elderly to receive the milk 3 times per day produced by lactating cows fed with the following diet, one of the group is control (C), without vitamin E, selenium, sunflower oil in the cow's food.
arm group label: Milk Antioxidant group(A)
arm group type: Experimental
description: Using a randomized block design, 25 institutionalized elderly to receive the milk produced by lactating cows fed with the following diet: control (C) +vitamin E+ selenium (A).
arm group label: Milk Oil group(O)
arm group type: Experimental
description: Using a randomized block design, 25 institutionalized elderly to receive the milk produced by lactating cows fed with the following diets: control (C)+sunflower oil (O).
arm group label: Milk Antioxidant and oil(AO)
arm group type: Experimental
description: Using a randomized block design, 25 institutionalized elderly to receive the milk produced by lactating cows fed with the following diets: control C+sunflower oil+vitamin E+selenium (AO) .
intervention type: Dietary Supplement
intervention name: Milk Antioxidant group(A)
description: There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets: control (C)+selenium and vitamin E (A).
arm group label: Milk Antioxidant group(A)
other name: add control diet(C) in the cow's food
other name: add selenium in the cow's food
other name: add vitamin E in the cow's food
intervention type: Dietary Supplement
intervention name: Milk Oil group(O)
description: There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets: control (C)+sunflower oil (O).
arm group label: Milk Oil group(O)
other name: add control diet(C) in the cow's food
other name: add sunflower oil group in the cow's food
intervention type: Dietary Supplement
intervention name: Milk Antioxidant and oil(AO)
description: There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets:control (C)+selenium, vitamin E and sunflower oil (AO).
arm group label: Milk Antioxidant and oil(AO)
other name: add control diet(C) in the cow's food
other name: add selenium in the cow's food
other name: add vitamin E in the cow's food
other name: add sunflower oil in the cow's food
intervention type: Dietary Supplement
intervention name: Milk Control group(C)
description: There is no intervention pre-specified before the institutionalized elderly to receive three times per day of milk (total 600ml of milk all day) produced by lactating cows fed with the following diets: control (C)
arm group label: Milk Control group(C)
other name: add control diet (C) in the cow's food
other name: without vitamin E in the cow's food
other name: without selenium in the cow's food
other name: without sunflower oil in the cow's food
criteria: 
gender: All
minimum age: 60 Years
maximum age: 110 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Eduardo Ferriolli, PhD
role: Principal Investigator
affiliation: Study Principal Investigator
last name: Helio Vannucchi, PhD
role: Study Chair
affiliation: Study Chair investigator
facility: 
country: Brazil
citation: Barr SI, McCarron DA, Heaney RP, Dawson-Hughes B, Berga SL, Stern JS, Oparil S. Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults. J Am Diet Assoc. 2000 Jul;100(7):810-7. doi: 10.1016/S0002-8223(00)00236-4.
PMID: 10916520
citation: Bouis HE, Hotz C, McClafferty B, Meenakshi JV, Pfeiffer WH. Biofortification: a new tool to reduce micronutrient malnutrition. Food Nutr Bull. 2011 Mar;32(1 Suppl):S31-40. doi: 10.1177/15648265110321S105.
PMID: 21717916
citation: Witkowska Z, Michalak I, Korczynski M, Szoltysik M, Swiniarska M, Dobrzanski Z, Tuhy L, Samoraj M, Chojnacka K. Biofortification of milk and cheese with microelements by dietary feed bio-preparations. J Food Sci Technol. 2015 Oct;52(10):6484-92. doi: 10.1007/s13197-014-1696-9. Epub 2015 Jan 21.
PMID: 26396393
citation: Kratz M, Baars T, Guyenet S. The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease. Eur J Nutr. 2013 Feb;52(1):1-24. doi: 10.1007/s00394-012-0418-1. Epub 2012 Jul 19.
PMID: 22810464
responsible party type: Sponsor-Investigator
investigator affiliation: University of Sao Paulo
investigator full name: Eduardo Ferriolli
investigator title: Assistant professor
mesh term: Vitamin E Deficiency
mesh term: Vitamins
mesh term: Vitamin E
mesh term: Tocopherols
mesh term: Tocotrienols
mesh term: alpha-Tocopherol
mesh term: Selenium
mesh term: Antioxidants
sharing ipd: No