<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02968537</url>
  </required_header>
  <id_info>
    <org_study_id>INTRA-2016-00988</org_study_id>
    <nct_id>NCT02968537</nct_id>
  </id_info>
  <brief_title>Learning to Resist the Urge: Inhibition Training in Abstinent Patients With Alcohol Use Disorders</brief_title>
  <acronym>INTRA</acronym>
  <official_title>Learning to Resist the Urge: Inhibition Training in Abstinent Patients With Alcohol Use Disorders. A Randomized Controlled Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Bern</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Clinic Südhang</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Forel Clinic</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>Psychiatric Center Muensingen</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Bern</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The study aims to investigate the effects of a short computerized training as a therapeutic&#xD;
      add-on to standard therapy in patients with alcohol-use disorder.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Therapeutic interventions to treat alcohol use disorders (AUD) still need to be improved. A&#xD;
      novel alcohol-specific inhibition-training seems to be a promising new intervention. In this&#xD;
      study, recently abstinent patients with AUD attending an inpatient treatment program will be&#xD;
      randomly assigned to one of two alcohol-specific inhibition-training groups (varying in&#xD;
      Go/NoGo-ratio) or to a control condition. Besides the effects on drinking behavior,&#xD;
      inhibition and implicit attitudes, the investigators expect the training to influence&#xD;
      neurophysiological reactivity to alcohol related stimuli. A subgroup of patients will&#xD;
      therefore additionally undergo EEG recording so that the neurophysiological effects of the&#xD;
      training can be assessed and related to clinical outcome. Furthermore, since training effects&#xD;
      rely on learning processes, the influence of endogenous cortisol level (a&#xD;
      consolidation-enhancer which peaks in the morning) on training outcome will be examined by&#xD;
      the variation of daytime of the training. All patients' inhibitory control and implicit&#xD;
      associations towards alcohol will be measured before and after training. The training effects&#xD;
      will be examined on proximal outcome variables (e.g. implicit associations, inhibitory&#xD;
      control, abstinence related self-efficacy, craving) and on distal outcome variables at 3-, 6-&#xD;
      and 12- months follow-up (e.g. percent abstinent days (primary outcome)).&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">December 2016</start_date>
  <completion_date type="Actual">July 2020</completion_date>
  <primary_completion_date type="Actual">September 2019</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Percent days of abstinence 3-months follow-up.</measure>
    <time_frame>3-months follow-up</time_frame>
    <description>Percentage of abstinent days in 3-months follow-up. This will be measured with the timeline follow back (TFB), which is a validated procedure to aid recall of past drinking and evaluates information about drinking behavior.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Inhibition Go/NoGo</measure>
    <time_frame>Post training, i.e. between 1 and 7 days after completion of the last (i.e. the 6th) training session</time_frame>
    <description>Inhibitory control as assessed with a Go/NoGo task.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Neurophysiology of inhibitory Control (Go/NoGo)</measure>
    <time_frame>Post training, i.e. between 1 and 7 days after completion of the last (i.e. the 6th) training session</time_frame>
    <description>Neurophysiological correlates of inhibitory control as assessed with EEG-measurement during the Go-NOGo-task. ERPs in response to NoGo-Stimuli will be calculated and the N2/p3-complex will be analyzed</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Implicit associations (IAT)</measure>
    <time_frame>Post training, i.e. between 1 and 7 days after completion of the last (i.e. the 6th) training session</time_frame>
    <description>Implicit associations as assessed with an alcohol-related implicit association task (IAT)</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Heavy drinking days in 3 months follow-up</measure>
    <time_frame>3 months follow-up</time_frame>
    <description>in 3-months follow-up. This will be measured Heavy drinking days in 3 months follow-up, measured with the timeline follow back (TFB), which is a validated procedure to aid recall of past drinking and evaluates information about drinking behavior.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Abstinence related self-efficacy</measure>
    <time_frame>Post-training (i.e. between 1 and 7 days after completion of the training session); discharge, 3-, 6- and 12-months follow-up</time_frame>
    <description>Self efficacy will be assessed with the alcohol abstinence self-efficacy scale (AASE).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Craving</measure>
    <time_frame>Post-training (i.e. between 1 and 7 days after completion of the last training session); discharge, 3-, 6- and 12-months follow-up</time_frame>
    <description>Craving will be measured with the German version of the Obsessive compulsive drinking scale (OCDS-G).</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Time to first drink</measure>
    <time_frame>3-, 6- and 12-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Percent heavy drinking days</measure>
    <time_frame>3-, 6- and 12-months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Inhibition (SST)</measure>
    <time_frame>Post-training; i.e. between 1 and 7 days after completion of the last (i.e. the 6th) training session</time_frame>
    <description>Inhibitory control will be assessed with a Stop-Signal task</description>
  </secondary_outcome>
  <number_of_arms>6</number_of_arms>
  <enrollment type="Actual">242</enrollment>
  <condition>Alcohol Dependence</condition>
  <arm_group>
    <arm_group_label>Alc-IT (50/50) (morning)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Alc-IT (50/50) (morning): This alcohol-specific inhibition-training (Alc-IT) training group will operate with a Go/NoGo ratio of 50/50 (Houben et al. 2011; 2012): This original version of the Alc-inhibition-training will include 80 alcoholic NoGo trials as well as 80 non-alcoholic Go trials. In order to arrive at the same training length while keeping the number of Alc-NoGo-pairings constant and the Go/NoGo-ratio at 50/50, it will additionally include 80 neutral Go-trials as well as 80 neutral NoGo-trials. It will thus consist of 320 trials and take about 10.5 minutes to be completed. In the morning group, this training will be administered within the first 2 hours after awakening.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Alc-IT (75/25) (morning)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>This version of the alcohol-specific inhibition-training (Alc-IT) will operate with a Go/NoGo-ratio of 75/25. It will equally include 80 Alcoholic NoGo-trials and 80 non-alcoholic Go-trials, but now 160 neutral Go-trials will complete the set. This training will also consist of 320 trials and take about 10.5 minutes. In the morning group, this training will be administered within the first 2 hours after awakening.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Control-training (morning)</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>This group will receive an unspecific inhibition training. this training is of the same length and difficulty as the two Alc-inhibition-trainings. In the morning group, this training will be administered within the first 2 hours after awakening.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Alc-IT (50/50) (afternoon)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Alc-IT (50/50) (afternoon): As in the arm &quot;Alc-IT (50/50) (morning)&quot;, this alcohol-specific inhibition-training (Alc-IT) group will operate with a Go/NoGo ratio of 50/50 (Houben et al. 2011; 2012): This original version of the Alc-inhibition-training will include 80 alcoholic NoGo trials as well as 80 non-alcoholic Go trials. In order to arrive at the same training length while keeping the number of Alc-NoGo-pairings constant and the Go/NoGo-ratio at 50/50, it will additionally include 80 neutral Go-trials as well as 80 neutral NoGo-trials. It will thus consist of 320 trials and take about 10.5 minutes to be completed. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Alc-IT (75/25) (afternoon)</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>As in the arm &quot;Alc-IT (75/25) (morning)&quot;, this version of the alcohol-specific inhibition-training (Alc-IT) will operate with a Go/NoGo-ratio of 75/25. It will equally include 80 Alcoholic NoGo-trials and 80 non-alcoholic Go-trials, but now 160 neutral Go-trials will complete the set. This training will also consist of 320 trials and take about 10.5 minutes. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Control-training (afternoon)</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>As in the arm &quot;Control-training (morning), this group will receive an unspecific inhibition training. This training is of the same length and difficulty as the two Alc-inhibition-trainings. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.</description>
  </arm_group>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Alc-IT (50/50) (morning)</intervention_name>
    <description>This alcohol-specific inhibition-training (Alc-IT) training group will operate with a Go/NoGo ratio of 50/50 (Houben et al. 2011; 2012): This original version of the Alc-inhibition-training will include 80 alcoholic NoGo trials as well as 80 non-alcoholic Go trials. In order to arrive at the same training length while keeping the number of Alc-NoGo-pairings constant and the Go/NoGo-ratio at 50/50, it will additionally include 80 neutral Go-trials as well as 80 neutral NoGo-trials. It will thus consist of 320 trials and take about 10.5 minutes to be completed. In the morning group, this training will be administered within the first 2 hours after awakening.</description>
    <arm_group_label>Alc-IT (50/50) (morning)</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Alc-IT (75/25) (morning)</intervention_name>
    <description>This version of the alcohol-specific inhibition-training (Alc-IT) will operate with a Go/NoGo-ratio of 75/25. It will equally include 80 Alcoholic NoGo-trials and 80 non-alcoholic Go-trials, but now 160 neutral Go-trials will complete the set. This training will also consist of 320 trials and take about 10.5 minutes. In the morning group, this training will be administered within the first 2 hours after awakening.</description>
    <arm_group_label>Alc-IT (75/25) (morning)</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Control-training (morning)</intervention_name>
    <description>This group will receive an unspecific inhibition training. this training is of the same length and difficulty as the two Alc-inhibition-trainings. In the morning group, this training will be administered within the first 2 hours after awakening.</description>
    <arm_group_label>Control-training (morning)</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Alc-IT (50/50) (afternoon)</intervention_name>
    <description>As in the arm &quot;Alc-IT (50/50) (morning)&quot;, this alcohol-specific inhibition-training (Alc-IT) group will operate with a Go/NoGo ratio of 50/50 (Houben et al. 2011; 2012): This original version of the Alc-inhibition-training will include 80 alcoholic NoGo trials as well as 80 non-alcoholic Go trials. In order to arrive at the same training length while keeping the number of Alc-NoGo-pairings constant and the Go/NoGo-ratio at 50/50, it will additionally include 80 neutral Go-trials as well as 80 neutral NoGo-trials. It will thus consist of 320 trials and take about 10.5 minutes to be completed. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.</description>
    <arm_group_label>Alc-IT (50/50) (afternoon)</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Alc-IT (75/25) (afternoon)</intervention_name>
    <description>As in the arm &quot;Alc-IT (75/25) (morning)&quot;, this version of the alcohol-specific inhibition-training (Alc-IT) will operate with a Go/NoGo-ratio of 75/25. It will equally include 80 Alcoholic NoGo-trials and 80 non-alcoholic Go-trials, but now 160 neutral Go-trials will complete the set. This training will also consist of 320 trials and take about 10.5 minutes. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.</description>
    <arm_group_label>Alc-IT (75/25) (afternoon)</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Control-training (afternoon)</intervention_name>
    <description>As in the arm &quot;Control-training (morning), this group will receive an unspecific inhibition training. This training is of the same length and difficulty as the two Alc-inhibition-trainings. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.</description>
    <arm_group_label>Control-training (afternoon)</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Abstinent patients with an alcohol use disorder in the 12-week inpatient program of&#xD;
             the Clinic Südhang or the Forel Clinic,&#xD;
&#xD;
          -  Abstained from alcohol for at least 4 weeks (in relation to timepoint when training&#xD;
             will start),&#xD;
&#xD;
          -  Informed Consent as documented by signature.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Other main psychiatric diagnosis than alcohol use disorder (comorbidity is allowed if&#xD;
             the alcohol use disorder is to be considered the main diagnosis),&#xD;
&#xD;
          -  other severe substance use disorder (except nicotine), even as secondary diagnosis&#xD;
&#xD;
          -  Neurocognitive problems (e.g. Korsakoff syndrome),&#xD;
&#xD;
          -  Current medical conditions excluding participation (e.g. acute infectious disease),&#xD;
&#xD;
          -  Inability to read and understand the participant's information,&#xD;
&#xD;
          -  Enrolment of the investigator, his/her family members, employees and other dependent&#xD;
             persons.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>18 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Maria Stein, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Bern, University Hospital for Psychiatry</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Leila Soravia, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Bern, University Hospital for Psychiatry</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Franz Moggi, PD</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Bern, University Hospital for Psychiatry</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Forel Klinik</name>
      <address>
        <city>Ellikon</city>
        <country>Switzerland</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Klinik Südhang</name>
      <address>
        <city>Kirchlindach</city>
        <country>Switzerland</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <name>Psychiatric Center Muensingen</name>
      <address>
        <city>Münsingen</city>
        <country>Switzerland</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Switzerland</country>
  </location_countries>
  <verification_date>May 2022</verification_date>
  <study_first_submitted>November 10, 2016</study_first_submitted>
  <study_first_submitted_qc>November 15, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">November 18, 2016</study_first_posted>
  <last_update_submitted>May 3, 2022</last_update_submitted>
  <last_update_submitted_qc>May 3, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">May 4, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Alcohol use disorders</keyword>
  <keyword>inhibition</keyword>
  <keyword>EEG</keyword>
  <keyword>cortisol</keyword>
  <keyword>Training</keyword>
  <keyword>clinical outcome measures</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Alcoholism</mesh_term>
    <mesh_term>Alcohol Drinking</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02968537
org study id: INTRA-2016-00988
nct id: NCT02968537
lead sponsor: 
collaborator: 
collaborator: 
collaborator: 
has dmc: No
The study aims to investigate the effects of a short computerized training as a therapeutic
      add-on to standard therapy in patients with alcohol-use disorder.
Therapeutic interventions to treat alcohol use disorders (AUD) still need to be improved. A
      novel alcohol-specific inhibition-training seems to be a promising new intervention. In this
      study, recently abstinent patients with AUD attending an inpatient treatment program will be
      randomly assigned to one of two alcohol-specific inhibition-training groups (varying in
      Go/NoGo-ratio) or to a control condition. Besides the effects on drinking behavior,
      inhibition and implicit attitudes, the investigators expect the training to influence
      neurophysiological reactivity to alcohol related stimuli. A subgroup of patients will
      therefore additionally undergo EEG recording so that the neurophysiological effects of the
      training can be assessed and related to clinical outcome. Furthermore, since training effects
      rely on learning processes, the influence of endogenous cortisol level (a
      consolidation-enhancer which peaks in the morning) on training outcome will be examined by
      the variation of daytime of the training. All patients' inhibitory control and implicit
      associations towards alcohol will be measured before and after training. The training effects
      will be examined on proximal outcome variables (e.g. implicit associations, inhibitory
      control, abstinence related self-efficacy, craving) and on distal outcome variables at 3-, 6-
      and 12- months follow-up (e.g. percent abstinent days (primary outcome)).
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
measure: Percent days of abstinence 3-months follow-up.
time frame: 3-months follow-up
description: Percentage of abstinent days in 3-months follow-up. This will be measured with the timeline follow back (TFB), which is a validated procedure to aid recall of past drinking and evaluates information about drinking behavior.
measure: Inhibition Go/NoGo
time frame: Post training, i.e. between 1 and 7 days after completion of the last (i.e. the 6th) training session
description: Inhibitory control as assessed with a Go/NoGo task.
measure: Neurophysiology of inhibitory Control (Go/NoGo)
time frame: Post training, i.e. between 1 and 7 days after completion of the last (i.e. the 6th) training session
description: Neurophysiological correlates of inhibitory control as assessed with EEG-measurement during the Go-NOGo-task. ERPs in response to NoGo-Stimuli will be calculated and the N2/p3-complex will be analyzed
measure: Implicit associations (IAT)
time frame: Post training, i.e. between 1 and 7 days after completion of the last (i.e. the 6th) training session
description: Implicit associations as assessed with an alcohol-related implicit association task (IAT)
measure: Heavy drinking days in 3 months follow-up
time frame: 3 months follow-up
description: in 3-months follow-up. This will be measured Heavy drinking days in 3 months follow-up, measured with the timeline follow back (TFB), which is a validated procedure to aid recall of past drinking and evaluates information about drinking behavior.
measure: Abstinence related self-efficacy
time frame: Post-training (i.e. between 1 and 7 days after completion of the training session); discharge, 3-, 6- and 12-months follow-up
description: Self efficacy will be assessed with the alcohol abstinence self-efficacy scale (AASE).
measure: Craving
time frame: Post-training (i.e. between 1 and 7 days after completion of the last training session); discharge, 3-, 6- and 12-months follow-up
description: Craving will be measured with the German version of the Obsessive compulsive drinking scale (OCDS-G).
measure: Time to first drink
time frame: 3-, 6- and 12-months follow-up
measure: Percent heavy drinking days
time frame: 3-, 6- and 12-months follow-up
measure: Inhibition (SST)
time frame: Post-training; i.e. between 1 and 7 days after completion of the last (i.e. the 6th) training session
description: Inhibitory control will be assessed with a Stop-Signal task
arm group label: Alc-IT (50/50) (morning)
arm group type: Experimental
description: Alc-IT (50/50) (morning): This alcohol-specific inhibition-training (Alc-IT) training group will operate with a Go/NoGo ratio of 50/50 (Houben et al. 2011; 2012): This original version of the Alc-inhibition-training will include 80 alcoholic NoGo trials as well as 80 non-alcoholic Go trials. In order to arrive at the same training length while keeping the number of Alc-NoGo-pairings constant and the Go/NoGo-ratio at 50/50, it will additionally include 80 neutral Go-trials as well as 80 neutral NoGo-trials. It will thus consist of 320 trials and take about 10.5 minutes to be completed. In the morning group, this training will be administered within the first 2 hours after awakening.
arm group label: Alc-IT (75/25) (morning)
arm group type: Experimental
description: This version of the alcohol-specific inhibition-training (Alc-IT) will operate with a Go/NoGo-ratio of 75/25. It will equally include 80 Alcoholic NoGo-trials and 80 non-alcoholic Go-trials, but now 160 neutral Go-trials will complete the set. This training will also consist of 320 trials and take about 10.5 minutes. In the morning group, this training will be administered within the first 2 hours after awakening.
arm group label: Control-training (morning)
arm group type: Placebo Comparator
description: This group will receive an unspecific inhibition training. this training is of the same length and difficulty as the two Alc-inhibition-trainings. In the morning group, this training will be administered within the first 2 hours after awakening.
arm group label: Alc-IT (50/50) (afternoon)
arm group type: Experimental
description: Alc-IT (50/50) (afternoon): As in the arm "Alc-IT (50/50) (morning)", this alcohol-specific inhibition-training (Alc-IT) group will operate with a Go/NoGo ratio of 50/50 (Houben et al. 2011; 2012): This original version of the Alc-inhibition-training will include 80 alcoholic NoGo trials as well as 80 non-alcoholic Go trials. In order to arrive at the same training length while keeping the number of Alc-NoGo-pairings constant and the Go/NoGo-ratio at 50/50, it will additionally include 80 neutral Go-trials as well as 80 neutral NoGo-trials. It will thus consist of 320 trials and take about 10.5 minutes to be completed. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.
arm group label: Alc-IT (75/25) (afternoon)
arm group type: Experimental
description: As in the arm "Alc-IT (75/25) (morning)", this version of the alcohol-specific inhibition-training (Alc-IT) will operate with a Go/NoGo-ratio of 75/25. It will equally include 80 Alcoholic NoGo-trials and 80 non-alcoholic Go-trials, but now 160 neutral Go-trials will complete the set. This training will also consist of 320 trials and take about 10.5 minutes. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.
arm group label: Control-training (afternoon)
arm group type: Placebo Comparator
description: As in the arm "Control-training (morning), this group will receive an unspecific inhibition training. This training is of the same length and difficulty as the two Alc-inhibition-trainings. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.
intervention type: Behavioral
intervention name: Alc-IT (50/50) (morning)
description: This alcohol-specific inhibition-training (Alc-IT) training group will operate with a Go/NoGo ratio of 50/50 (Houben et al. 2011; 2012): This original version of the Alc-inhibition-training will include 80 alcoholic NoGo trials as well as 80 non-alcoholic Go trials. In order to arrive at the same training length while keeping the number of Alc-NoGo-pairings constant and the Go/NoGo-ratio at 50/50, it will additionally include 80 neutral Go-trials as well as 80 neutral NoGo-trials. It will thus consist of 320 trials and take about 10.5 minutes to be completed. In the morning group, this training will be administered within the first 2 hours after awakening.
arm group label: Alc-IT (50/50) (morning)
intervention type: Behavioral
intervention name: Alc-IT (75/25) (morning)
description: This version of the alcohol-specific inhibition-training (Alc-IT) will operate with a Go/NoGo-ratio of 75/25. It will equally include 80 Alcoholic NoGo-trials and 80 non-alcoholic Go-trials, but now 160 neutral Go-trials will complete the set. This training will also consist of 320 trials and take about 10.5 minutes. In the morning group, this training will be administered within the first 2 hours after awakening.
arm group label: Alc-IT (75/25) (morning)
intervention type: Behavioral
intervention name: Control-training (morning)
description: This group will receive an unspecific inhibition training. this training is of the same length and difficulty as the two Alc-inhibition-trainings. In the morning group, this training will be administered within the first 2 hours after awakening.
arm group label: Control-training (morning)
intervention type: Behavioral
intervention name: Alc-IT (50/50) (afternoon)
description: As in the arm "Alc-IT (50/50) (morning)", this alcohol-specific inhibition-training (Alc-IT) group will operate with a Go/NoGo ratio of 50/50 (Houben et al. 2011; 2012): This original version of the Alc-inhibition-training will include 80 alcoholic NoGo trials as well as 80 non-alcoholic Go trials. In order to arrive at the same training length while keeping the number of Alc-NoGo-pairings constant and the Go/NoGo-ratio at 50/50, it will additionally include 80 neutral Go-trials as well as 80 neutral NoGo-trials. It will thus consist of 320 trials and take about 10.5 minutes to be completed. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.
arm group label: Alc-IT (50/50) (afternoon)
intervention type: Behavioral
intervention name: Alc-IT (75/25) (afternoon)
description: As in the arm "Alc-IT (75/25) (morning)", this version of the alcohol-specific inhibition-training (Alc-IT) will operate with a Go/NoGo-ratio of 75/25. It will equally include 80 Alcoholic NoGo-trials and 80 non-alcoholic Go-trials, but now 160 neutral Go-trials will complete the set. This training will also consist of 320 trials and take about 10.5 minutes. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.
arm group label: Alc-IT (75/25) (afternoon)
intervention type: Behavioral
intervention name: Control-training (afternoon)
description: As in the arm "Control-training (morning), this group will receive an unspecific inhibition training. This training is of the same length and difficulty as the two Alc-inhibition-trainings. In contrast to the In the morning group, this afternoon group will receive the training in the afternoon.
arm group label: Control-training (afternoon)
criteria: 
gender: All
minimum age: 18 Years
maximum age: 18 Years
healthy volunteers: No
last name: Maria Stein, PhD
role: Principal Investigator
affiliation: University of Bern, University Hospital for Psychiatry
last name: Leila Soravia, PhD
role: Principal Investigator
affiliation: University of Bern, University Hospital for Psychiatry
last name: Franz Moggi, PD
role: Principal Investigator
affiliation: University of Bern, University Hospital for Psychiatry
facility: 
facility: 
facility: 
country: Switzerland
responsible party type: Sponsor
mesh term: Alcoholism
mesh term: Alcohol Drinking
sharing ipd: No