<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02997124</url>
  </required_header>
  <id_info>
    <org_study_id>07/16/IEC/JMMC&amp;RI</org_study_id>
    <nct_id>NCT02997124</nct_id>
  </id_info>
  <brief_title>Transversus Abdominis Plane Block in Iliac Crest harvest-is it Beneficial?</brief_title>
  <official_title>Transversus Abdominis Plane Block Supplementation During Iliac Crest Bone Graft Harvest - Its Influence on Postoperative Parameters</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Jubilee Mission Medical College and Research Institute</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Jubilee Mission Medical College and Research Institute</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The purpose of this study is to determine whether a supplemental Transversus Abdominis Plane&#xD;
      block administered intraoperatively improves the postoperative parameters in patients&#xD;
      undergoing Alveolar bone grafting with iliac crest harvest. It also aims to find out if there&#xD;
      is a decrease in the incidence of chronic pain or numbness at the harvest site.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      This study is a prospective, randomised, parallel group, single - centre trial evaluating the&#xD;
      postoperative parameters in patients receiving supplemental Transversus Abdominis Plane block&#xD;
      for anterior iliac crest harvest. It was conducted in 143 patients undergoing Alveolar bone&#xD;
      grafting with iliac crest bone graft.&#xD;
&#xD;
      Methodology:&#xD;
&#xD;
      Informed consent and approval of local ethics and research committee in Jubilee Mission&#xD;
      Medical College and Research Institute, Thrissur, India was obtained prior to initiation of&#xD;
      the study. A pilot study was done to determine the efficacy of the additional TAP block. The&#xD;
      results showed that the intervention improved patient analgesia and reduced the requirement&#xD;
      for rescue analgesics. A minimum sample size of 65 patients was calculated for each group to&#xD;
      obtain a power of 80% and confidence interval of 95%. 143 patients aged between 7 and 22&#xD;
      years posted for Alveolar bone grafting with anterior iliac crest harvest were assessed in&#xD;
      the study. Only those undergoing Alveolar bone grafting as a part of the reconstructive&#xD;
      procedure for cleft lip and palate were considered for the study. The patients who had&#xD;
      difficulty in mentation and communication,bleeding disorders, hepatic problems, infection of&#xD;
      the abdominal wall, renal dysfunction as well as allergy to the local anaesthetic were&#xD;
      excluded from the study. Patients undergoing revision surgeries were also excluded from the&#xD;
      study. All the candidates were randomly alloted to either of the two groups, using a computer&#xD;
      - generated number.&#xD;
&#xD;
      All the patients were premedicated with Midazolam 0.15mg kg-1 and Glycopyrolate 0.01mg kg-1&#xD;
      Anaesthesia was induced with Propofol 2 mg kg -1 and Fentanyl 2 mcg kg-1 .Vecuronium 0.1 mg&#xD;
      kg-1 was given to facilitate orotracheal intubation with a cuffed tube.Anaesthesia was&#xD;
      maintained with oxygen, nitrous oxide and sevoflurane. Prior to incision, all the patients&#xD;
      were given wound infiltration with 0.75 ml kg-1 of 0.2% Ropivacaine at the graft harvest&#xD;
      site. Those in group A received an additional ultrasound guided Transversus Abdominis Plane&#xD;
      block with a similar volume and concentration of Ropivacaine.&#xD;
&#xD;
      At the end of the surgical procedure, the patients were extubated awake, after giving I / V&#xD;
      Neostigmine 0.05 mg kg-1. Just prior to extubation, I/V Tramadol 0.5 mg kg-1 was given for&#xD;
      the pain in the postoperative period. In the recovery room, the pain and emergence delirium&#xD;
      were assessed by an independent observer every ten minutes during the first postoperative&#xD;
      hour.These were evaluated using the FLACC Behavioural Pain Assessment Scale and WATCHA Scale&#xD;
      respectively. They were subsequently shifted to the postoperative ward.&#xD;
&#xD;
      The next time point of assessment was 24 hours post - surgery, when the patient's pain and&#xD;
      ambulatory status were evaluated. The pain was ranked using the five - point verbal ranking&#xD;
      score. It was ranked as no pain, light pain, moderate pain, severe pain and intolerable pain,&#xD;
      with a score of 0,1,2,3 and 4 respectively. The total number of rescue analgesics demanded by&#xD;
      the patient on the first postoperative day was noted.Ambulatory status was graded using one -&#xD;
      day Cumulated Ambulatory Score.&#xD;
&#xD;
      The patients were followed up and questioned at six weeks and twelve weeks post operatively&#xD;
      for the presence of chronic pain, numbness or wound healing problems at the harvest site.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date>April 2016</start_date>
  <completion_date type="Actual">November 2016</completion_date>
  <primary_completion_date type="Actual">August 2016</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Mean pain scores</measure>
    <time_frame>First hour after extubation</time_frame>
    <description>Mean pain scores were assessed using the FLACC Behavioural Pain Assessment Scale,</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Emergence delirium</measure>
    <time_frame>First hour after extubation</time_frame>
    <description>Emergence delirium was assessed using WATCHA Scale during the first hour after extubation</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Pain scores</measure>
    <time_frame>24 hours after surgery</time_frame>
    <description>Pain scores using the five - point verbal ranking score 24 hours after surgery</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Ambulatory status</measure>
    <time_frame>24 hours after surgery</time_frame>
    <description>Ambulatory status was assessed using one - day Cumulated Ambulatory Score 24 hours after surgery</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Infection and delayed healing at the graft harvest site</measure>
    <time_frame>6 weeks after surgery</time_frame>
    <description>All patients were interviewed for the presence of infection or delayed healing at the graft harvest site 6 weeks after surgery.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Chronic pain, numbness or discomfort at graft harvest site</measure>
    <time_frame>12 weeks after the surgery</time_frame>
    <description>All the patients were reviewed 12 weeks after surgery for the presence of chronic pain, numbness or discomfort at iliac crest harvest</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">143</enrollment>
  <condition>Pain, Postoperative</condition>
  <arm_group>
    <arm_group_label>Local Infiltration with TAP block</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Ultrasound guided Transversus Abdominis Plane block is administered intraoperatively using 0.2% Ropivacaine.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Local Infiltration only</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Local Infiltration with 0.2% Ropivacaine.</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>local infiltration and TAP block</intervention_name>
    <description>Local infiltration of the iliac crest harvest site along with TAP block using 0.2 % Ropivacaine is done</description>
    <arm_group_label>Local Infiltration with TAP block</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>local infiltration only</intervention_name>
    <description>Only local infiltration with 0.2% Ropivacaine of the iliac crest harvest site is done.</description>
    <arm_group_label>Local Infiltration only</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Must undergo alveolar bone grafting as a part of the reconstructive procedure for&#xD;
             cleft lip and palate&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Revision procedure&#xD;
&#xD;
          -  History of difficulty in mentation and communication&#xD;
&#xD;
          -  Bleeding disorders, hepatic problems or renal dysfunction&#xD;
&#xD;
          -  Allergy to local anaesthetic&#xD;
&#xD;
          -  Presence of infection of anterior abdominal wall&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>4 Years</minimum_age>
    <maximum_age>22 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Vigil Peter, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Jubilee Mission Medical College and Research Institute</affiliation>
  </overall_official>
  <reference>
    <citation>Chiono J, Bernard N, Bringuier S, Biboulet P, Choquet O, Morau D, Capdevila X. The ultrasound-guided transversus abdominis plane block for anterior iliac crest bone graft postoperative pain relief: a prospective descriptive study. Reg Anesth Pain Med. 2010 Nov-Dec;35(6):520-4. doi: 10.1097/AAP.0b013e3181fa117a.</citation>
    <PMID>20975466</PMID>
  </reference>
  <reference>
    <citation>Sandhu HS, Grewal HS, Parvataneni H. Bone grafting for spinal fusion. Orthop Clin North Am. 1999 Oct;30(4):685-98. doi: 10.1016/s0030-5898(05)70120-6.</citation>
    <PMID>10471772</PMID>
  </reference>
  <reference>
    <citation>Heary RF, Schlenk RP, Sacchieri TA, Barone D, Brotea C. Persistent iliac crest donor site pain: independent outcome assessment. Neurosurgery. 2002 Mar;50(3):510-6; discussion 516-7. doi: 10.1097/00006123-200203000-00015.</citation>
    <PMID>11841718</PMID>
  </reference>
  <reference>
    <citation>DeOrio JK, Farber DC. Morbidity associated with anterior iliac crest bone grafting in foot and ankle surgery. Foot Ankle Int. 2005 Feb;26(2):147-51. doi: 10.1177/107110070502600206.</citation>
    <PMID>15737257</PMID>
  </reference>
  <reference>
    <citation>Silber JS, Anderson DG, Daffner SD, Brislin BT, Leland JM, Hilibrand AS, Vaccaro AR, Albert TJ. Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine (Phila Pa 1976). 2003 Jan 15;28(2):134-9. doi: 10.1097/00007632-200301150-00008.</citation>
    <PMID>12544929</PMID>
  </reference>
  <reference>
    <citation>Kim DH, Rhim R, Li L, Martha J, Swaim BH, Banco RJ, Jenis LG, Tromanhauser SG. Prospective study of iliac crest bone graft harvest site pain and morbidity. Spine J. 2009 Nov;9(11):886-92. doi: 10.1016/j.spinee.2009.05.006. Epub 2009 Jun 18.</citation>
    <PMID>19540168</PMID>
  </reference>
  <reference>
    <citation>O'Donnell BD, McDonnell JG, McShane AJ. The transversus abdominis plane (TAP) block in open retropubic prostatectomy. Reg Anesth Pain Med. 2006 Jan-Feb;31(1):91. doi: 10.1016/j.rapm.2005.10.006. No abstract available. Erratum In: Reg Anesth Pain Med. 2006 May-Jun;31(3):286. McDonnell, John G [added]; McShane, Alan J [added].</citation>
    <PMID>16418039</PMID>
  </reference>
  <reference>
    <citation>McDonnell JG, O'Donnell B, Curley G, Heffernan A, Power C, Laffey JG. The analgesic efficacy of transversus abdominis plane block after abdominal surgery: a prospective randomized controlled trial. Anesth Analg. 2007 Jan;104(1):193-7. doi: 10.1213/01.ane.0000250223.49963.0f. Erratum In: Anesth Analg. 2007 May;104(5):1108.</citation>
    <PMID>17179269</PMID>
  </reference>
  <reference>
    <citation>Kessler P, Thorwarth M, Bloch-Birkholz A, Nkenke E, Neukam FW. Harvesting of bone from the iliac crest--comparison of the anterior and posterior sites. Br J Oral Maxillofac Surg. 2005 Feb;43(1):51-6. doi: 10.1016/j.bjoms.2004.08.026.</citation>
    <PMID>15620775</PMID>
  </reference>
  <reference>
    <citation>Zijderveld SA, ten Bruggenkate CM, van Den Bergh JP, Schulten EA. Fractures of the iliac crest after split-thickness bone grafting for preprosthetic surgery: report of 3 cases and review of the literature. J Oral Maxillofac Surg. 2004 Jul;62(7):781-6. doi: 10.1016/j.joms.2003.12.018.</citation>
    <PMID>15218554</PMID>
  </reference>
  <reference>
    <citation>Rawashdeh MA, Telfah H. Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity. Br J Oral Maxillofac Surg. 2008 Dec;46(8):665-70. doi: 10.1016/j.bjoms.2008.07.184. Epub 2008 Aug 29.</citation>
    <PMID>18760515</PMID>
  </reference>
  <reference>
    <citation>Kalk WW, Raghoebar GM, Jansma J, Boering G. Morbidity from iliac crest bone harvesting. J Oral Maxillofac Surg. 1996 Dec;54(12):1424-9; discussion 1430. doi: 10.1016/s0278-2391(96)90257-8.</citation>
    <PMID>8957121</PMID>
  </reference>
  <verification_date>December 2016</verification_date>
  <study_first_submitted>December 15, 2016</study_first_submitted>
  <study_first_submitted_qc>December 16, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">December 19, 2016</study_first_posted>
  <last_update_submitted>December 20, 2016</last_update_submitted>
  <last_update_submitted_qc>December 20, 2016</last_update_submitted_qc>
  <last_update_posted type="Estimate">December 22, 2016</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Jubilee Mission Medical College and Research Institute</investigator_affiliation>
    <investigator_full_name>Dr. Vigil Peter</investigator_full_name>
    <investigator_title>Assistant Professor, Department of Anesthesia</investigator_title>
  </responsible_party>
  <keyword>Alveolar bone grafting</keyword>
  <keyword>delirium</keyword>
  <keyword>early ambulation</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Pain, Postoperative</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02997124
org study id: 07/16/IEC/JMMC&RI
nct id: NCT02997124
lead sponsor: 
has dmc: Yes
The purpose of this study is to determine whether a supplemental Transversus Abdominis Plane
      block administered intraoperatively improves the postoperative parameters in patients
      undergoing Alveolar bone grafting with iliac crest harvest. It also aims to find out if there
      is a decrease in the incidence of chronic pain or numbness at the harvest site.
This study is a prospective, randomised, parallel group, single - centre trial evaluating the
      postoperative parameters in patients receiving supplemental Transversus Abdominis Plane block
      for anterior iliac crest harvest. It was conducted in 143 patients undergoing Alveolar bone
      grafting with iliac crest bone graft.

      Methodology:

      Informed consent and approval of local ethics and research committee in Jubilee Mission
      Medical College and Research Institute, Thrissur, India was obtained prior to initiation of
      the study. A pilot study was done to determine the efficacy of the additional TAP block. The
      results showed that the intervention improved patient analgesia and reduced the requirement
      for rescue analgesics. A minimum sample size of 65 patients was calculated for each group to
      obtain a power of 80% and confidence interval of 95%. 143 patients aged between 7 and 22
      years posted for Alveolar bone grafting with anterior iliac crest harvest were assessed in
      the study. Only those undergoing Alveolar bone grafting as a part of the reconstructive
      procedure for cleft lip and palate were considered for the study. The patients who had
      difficulty in mentation and communication,bleeding disorders, hepatic problems, infection of
      the abdominal wall, renal dysfunction as well as allergy to the local anaesthetic were
      excluded from the study. Patients undergoing revision surgeries were also excluded from the
      study. All the candidates were randomly alloted to either of the two groups, using a computer
      - generated number.

      All the patients were premedicated with Midazolam 0.15mg kg-1 and Glycopyrolate 0.01mg kg-1
      Anaesthesia was induced with Propofol 2 mg kg -1 and Fentanyl 2 mcg kg-1 .Vecuronium 0.1 mg
      kg-1 was given to facilitate orotracheal intubation with a cuffed tube.Anaesthesia was
      maintained with oxygen, nitrous oxide and sevoflurane. Prior to incision, all the patients
      were given wound infiltration with 0.75 ml kg-1 of 0.2% Ropivacaine at the graft harvest
      site. Those in group A received an additional ultrasound guided Transversus Abdominis Plane
      block with a similar volume and concentration of Ropivacaine.

      At the end of the surgical procedure, the patients were extubated awake, after giving I / V
      Neostigmine 0.05 mg kg-1. Just prior to extubation, I/V Tramadol 0.5 mg kg-1 was given for
      the pain in the postoperative period. In the recovery room, the pain and emergence delirium
      were assessed by an independent observer every ten minutes during the first postoperative
      hour.These were evaluated using the FLACC Behavioural Pain Assessment Scale and WATCHA Scale
      respectively. They were subsequently shifted to the postoperative ward.

      The next time point of assessment was 24 hours post - surgery, when the patient's pain and
      ambulatory status were evaluated. The pain was ranked using the five - point verbal ranking
      score. It was ranked as no pain, light pain, moderate pain, severe pain and intolerable pain,
      with a score of 0,1,2,3 and 4 respectively. The total number of rescue analgesics demanded by
      the patient on the first postoperative day was noted.Ambulatory status was graded using one -
      day Cumulated Ambulatory Score.

      The patients were followed up and questioned at six weeks and twelve weeks post operatively
      for the presence of chronic pain, numbness or wound healing problems at the harvest site.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Double (Participant, Outcomes Assessor)
measure: Mean pain scores
time frame: First hour after extubation
description: Mean pain scores were assessed using the FLACC Behavioural Pain Assessment Scale,
measure: Emergence delirium
time frame: First hour after extubation
description: Emergence delirium was assessed using WATCHA Scale during the first hour after extubation
measure: Pain scores
time frame: 24 hours after surgery
description: Pain scores using the five - point verbal ranking score 24 hours after surgery
measure: Ambulatory status
time frame: 24 hours after surgery
description: Ambulatory status was assessed using one - day Cumulated Ambulatory Score 24 hours after surgery
measure: Infection and delayed healing at the graft harvest site
time frame: 6 weeks after surgery
description: All patients were interviewed for the presence of infection or delayed healing at the graft harvest site 6 weeks after surgery.
measure: Chronic pain, numbness or discomfort at graft harvest site
time frame: 12 weeks after the surgery
description: All the patients were reviewed 12 weeks after surgery for the presence of chronic pain, numbness or discomfort at iliac crest harvest
arm group label: Local Infiltration with TAP block
arm group type: Experimental
description: Ultrasound guided Transversus Abdominis Plane block is administered intraoperatively using 0.2% Ropivacaine.
arm group label: Local Infiltration only
arm group type: Experimental
description: Local Infiltration with 0.2% Ropivacaine.
intervention type: Procedure
intervention name: local infiltration and TAP block
description: Local infiltration of the iliac crest harvest site along with TAP block using 0.2 % Ropivacaine is done
arm group label: Local Infiltration with TAP block
intervention type: Procedure
intervention name: local infiltration only
description: Only local infiltration with 0.2% Ropivacaine of the iliac crest harvest site is done.
arm group label: Local Infiltration only
criteria: 
gender: All
minimum age: 4 Years
maximum age: 22 Years
healthy volunteers: No
last name: Vigil Peter, MD
role: Principal Investigator
affiliation: Jubilee Mission Medical College and Research Institute
citation: Chiono J, Bernard N, Bringuier S, Biboulet P, Choquet O, Morau D, Capdevila X. The ultrasound-guided transversus abdominis plane block for anterior iliac crest bone graft postoperative pain relief: a prospective descriptive study. Reg Anesth Pain Med. 2010 Nov-Dec;35(6):520-4. doi: 10.1097/AAP.0b013e3181fa117a.
PMID: 20975466
citation: Sandhu HS, Grewal HS, Parvataneni H. Bone grafting for spinal fusion. Orthop Clin North Am. 1999 Oct;30(4):685-98. doi: 10.1016/s0030-5898(05)70120-6.
PMID: 10471772
citation: Heary RF, Schlenk RP, Sacchieri TA, Barone D, Brotea C. Persistent iliac crest donor site pain: independent outcome assessment. Neurosurgery. 2002 Mar;50(3):510-6; discussion 516-7. doi: 10.1097/00006123-200203000-00015.
PMID: 11841718
citation: DeOrio JK, Farber DC. Morbidity associated with anterior iliac crest bone grafting in foot and ankle surgery. Foot Ankle Int. 2005 Feb;26(2):147-51. doi: 10.1177/107110070502600206.
PMID: 15737257
citation: Silber JS, Anderson DG, Daffner SD, Brislin BT, Leland JM, Hilibrand AS, Vaccaro AR, Albert TJ. Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine (Phila Pa 1976). 2003 Jan 15;28(2):134-9. doi: 10.1097/00007632-200301150-00008.
PMID: 12544929
citation: Kim DH, Rhim R, Li L, Martha J, Swaim BH, Banco RJ, Jenis LG, Tromanhauser SG. Prospective study of iliac crest bone graft harvest site pain and morbidity. Spine J. 2009 Nov;9(11):886-92. doi: 10.1016/j.spinee.2009.05.006. Epub 2009 Jun 18.
PMID: 19540168
citation: O'Donnell BD, McDonnell JG, McShane AJ. The transversus abdominis plane (TAP) block in open retropubic prostatectomy. Reg Anesth Pain Med. 2006 Jan-Feb;31(1):91. doi: 10.1016/j.rapm.2005.10.006. No abstract available. Erratum In: Reg Anesth Pain Med. 2006 May-Jun;31(3):286. McDonnell, John G [added]; McShane, Alan J [added].
PMID: 16418039
citation: McDonnell JG, O'Donnell B, Curley G, Heffernan A, Power C, Laffey JG. The analgesic efficacy of transversus abdominis plane block after abdominal surgery: a prospective randomized controlled trial. Anesth Analg. 2007 Jan;104(1):193-7. doi: 10.1213/01.ane.0000250223.49963.0f. Erratum In: Anesth Analg. 2007 May;104(5):1108.
PMID: 17179269
citation: Kessler P, Thorwarth M, Bloch-Birkholz A, Nkenke E, Neukam FW. Harvesting of bone from the iliac crest--comparison of the anterior and posterior sites. Br J Oral Maxillofac Surg. 2005 Feb;43(1):51-6. doi: 10.1016/j.bjoms.2004.08.026.
PMID: 15620775
citation: Zijderveld SA, ten Bruggenkate CM, van Den Bergh JP, Schulten EA. Fractures of the iliac crest after split-thickness bone grafting for preprosthetic surgery: report of 3 cases and review of the literature. J Oral Maxillofac Surg. 2004 Jul;62(7):781-6. doi: 10.1016/j.joms.2003.12.018.
PMID: 15218554
citation: Rawashdeh MA, Telfah H. Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity. Br J Oral Maxillofac Surg. 2008 Dec;46(8):665-70. doi: 10.1016/j.bjoms.2008.07.184. Epub 2008 Aug 29.
PMID: 18760515
citation: Kalk WW, Raghoebar GM, Jansma J, Boering G. Morbidity from iliac crest bone harvesting. J Oral Maxillofac Surg. 1996 Dec;54(12):1424-9; discussion 1430. doi: 10.1016/s0278-2391(96)90257-8.
PMID: 8957121
responsible party type: Principal Investigator
investigator affiliation: Jubilee Mission Medical College and Research Institute
investigator full name: Dr. Vigil Peter
investigator title: Assistant Professor, Department of Anesthesia
mesh term: Pain, Postoperative
sharing ipd: No