<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02978183</url>
  </required_header>
  <id_info>
    <org_study_id>ST266-AC-201</org_study_id>
    <nct_id>NCT02978183</nct_id>
  </id_info>
  <brief_title>Evaluation of the Effectiveness of ST266 Ophthalmic Drops Compared to Placebo to Treat Allergic Conjunctivitis</brief_title>
  <official_title>A Multi-Center, Double-Masked, Randomized, Phase 2 Evaluation of the Effectiveness of ST266 Ophthalmic Drops Compared to Placebo for the Treatment of Allergic Conjunctivitis Using a Modified Conjunctival Allergen Challenge Model</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Noveome Biotherapeutics, formerly Stemnion</agency>
      <agency_class>Industry</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Noveome Biotherapeutics, formerly Stemnion</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The purpose of this study is to evaluate the efficacy of ST266 ophthalmic drops compared to&#xD;
      placebo for the treatment of the signs and symptoms of allergic conjunctivitis.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The study is a multi-center, double-masked, randomized, placebo-controlled, modified&#xD;
      conjunctival allergen challenge (CAC) model. The primary endpoints of ocular itching and&#xD;
      conjunctival redness will be evaluated at the subject's final visit. Subjects who meet&#xD;
      inclusion criteria will be randomized to one of two treatment groups (1:1). Randomization&#xD;
      will be stratified by average post-CAC itching scores at baseline.&#xD;
&#xD;
      Subjects will be evaluated at baseline and on Days 6, 7 and 8.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">December 2016</start_date>
  <completion_date type="Actual">November 2017</completion_date>
  <primary_completion_date type="Actual">February 2017</primary_completion_date>
  <phase>Phase 2</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Investigator)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Ocular Itching</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Ocular itching evaluated by the subject. Ocular itching was evaluated on a 0-4 scale (with half unit increments allowed). Lower scores indicated less itching.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Conjunctival Redness</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Conjunctival redness evaluated by the investigator. Conjunctival redness was evaluated on a 0-4 scale (with half unit increments allowed). Lower scores indicated less redness.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Ciliary Redness</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Ciliary redness evaluated by the investigator. Ciliary redness was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less redness.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Episcleral Redness</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Episcleral redness evaluated by the investigator. Episcleral redness was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less redness.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Chemosis</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Chemosis evaluated by the investigator. Chemosis was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less chemosis.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Eyelid Swelling</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Eyelid swelling evaluated by the subject. Eyelid swelling was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less swelling.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Tearing/Watery Eyes</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Tearing evaluated by the subject. Tearing was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less tearing.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Rhinorrhea</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Rhinorrhea evaluated by the subject. Rhinorrhea was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Nasal Pruritus</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Nasal Pruritus evaluated by the subject. Nasal pruritus was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Ear or Palate Pruritus</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Ear or palate pruritus evaluated by the subject. Ear or palate pruritus was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Nasal Congestion</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>Nasal congestion evaluated by the subject. Nasal congestion was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Nasal Composite Score</measure>
    <time_frame>Day 7 and 8</time_frame>
    <description>A composite score of presence or absence of at least one nasal symptom evaluated by the subject</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">70</enrollment>
  <condition>Allergic Conjunctivitis</condition>
  <arm_group>
    <arm_group_label>Group 1</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>1X ST266 dosed 4 times a day for 8 days</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Group 2</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Placebo dosed 4 times a day for 8 days</description>
  </arm_group>
  <intervention>
    <intervention_type>Biological</intervention_type>
    <intervention_name>ST266</intervention_name>
    <description>One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
    <arm_group_label>Group 1</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Saline (0.9% NaCl)</intervention_name>
    <description>One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
    <arm_group_label>Group 2</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  be at least 18 years of age of either gender and any race;&#xD;
&#xD;
          -  provide written informed consent and sign the HIPAA form;&#xD;
&#xD;
          -  be willing and able to follow all instructions and attend all study visits; have a&#xD;
             positive history of ocular allergies and a positive skin test reaction to a seasonal&#xD;
             AND perennial allergen as confirmed by an allergic skin test;&#xD;
&#xD;
          -  be able and willing to avoid all disallowed medication for the appropriate washout&#xD;
             period and during the study;&#xD;
&#xD;
          -  be able and willing to discontinue wearing contact lenses for at least 72 hours prior&#xD;
             to and during the study trial period;&#xD;
&#xD;
          -  (for females capable of becoming pregnant) agree to have urine pregnancy testing&#xD;
             performed at screening (must be negative) and at the study exit; must not be&#xD;
             lactating; and must agree to use a medically acceptable form of birth control&#xD;
             throughout the study duration and for at least 14 days prior to instillation of&#xD;
             investigational product). Women considered capable of becoming pregnant include all&#xD;
             females who have experienced menarche and have not experienced menopause (as defined&#xD;
             by amenorrhea for greater than 12 consecutive months) or have not undergone successful&#xD;
             surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral&#xD;
             oophorectomy);&#xD;
&#xD;
          -  have a calculated visual acuity of 0.7 logMAR or better in each eye as measured using&#xD;
             an ETDRS chart;&#xD;
&#xD;
          -  have a positive post-CAC reaction;&#xD;
&#xD;
          -  have a positive post-CAC reaction in two out of the first three time points;&#xD;
&#xD;
          -  be able to self-administer eye drops satisfactorily or have a caregiver at home&#xD;
             routinely available for this purpose.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  have known contraindications or sensitivities to the use of the investigational&#xD;
             product or any of its components;&#xD;
&#xD;
          -  have any ocular condition that, in the opinion of the investigator, could affect the&#xD;
             subject's safety or trial parameters (including but not limited to narrow angle&#xD;
             glaucoma, clinically significant blepharitis, follicular conjunctivitis, iritis, or&#xD;
             pterygium);&#xD;
&#xD;
          -  have had ocular surgical intervention within 3 months prior to initiating the study or&#xD;
             during the study and/or a history of refractive surgery within the past 6 months;&#xD;
&#xD;
          -  have a known history of retinal detachment, diabetic retinopathy, or active retinal&#xD;
             disease;&#xD;
&#xD;
          -  have the presence of an active ocular infection (bacterial, viral or fungal) or&#xD;
             positive history of an ocular herpetic infection at any visit;&#xD;
&#xD;
          -  use any of the disallowed medications during the period indicated prior to and during&#xD;
             the study;&#xD;
&#xD;
          -  have any significant illness (e.g. any autoimmune disease requiring therapy, severe&#xD;
             cardiovascular disease [including arrhythmias]) the investigator feels could be&#xD;
             expected to interfere with the subject's health or with the study parameters and/or&#xD;
             put the subject at any unnecessary risk (includes but is not limited to: poorly&#xD;
             controlled hypertension or poorly controlled diabetes, a history of status&#xD;
             asthmaticus, organ transplants, a known history of persistent moderate or severe&#xD;
             asthma, or a known history of moderate to severe allergic asthmatic reactions to any&#xD;
             of the study allergens);&#xD;
&#xD;
          -  manifest signs or symptoms of clinically active allergic conjunctivitis in either eye&#xD;
             at the screening visit;&#xD;
&#xD;
          -  have planned surgery (ocular or systemic) during the trial period or within 30 days&#xD;
             after;&#xD;
&#xD;
          -  have used an investigational drug or medical device within 30 days of the study or be&#xD;
             concurrently enrolled in another investigational product trial;&#xD;
&#xD;
          -  be a female who is currently pregnant, planning a pregnancy, or lactating.&#xD;
&#xD;
          -  have cancer or have a history of cancer within the last 5 years.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <address>
        <city>Andover</city>
        <state>Massachusetts</state>
        <zip>01810</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location>
    <facility>
      <address>
        <city>Memphis</city>
        <state>Tennessee</state>
        <zip>38119</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <verification_date>March 2023</verification_date>
  <study_first_submitted>November 28, 2016</study_first_submitted>
  <study_first_submitted_qc>November 28, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">November 30, 2016</study_first_posted>
  <results_first_submitted>August 16, 2021</results_first_submitted>
  <results_first_submitted_qc>September 14, 2021</results_first_submitted_qc>
  <results_first_posted type="Actual">September 16, 2021</results_first_posted>
  <disposition_first_submitted>September 24, 2018</disposition_first_submitted>
  <disposition_first_submitted_qc>September 24, 2018</disposition_first_submitted_qc>
  <disposition_first_posted type="Actual">September 26, 2018</disposition_first_posted>
  <last_update_submitted>March 13, 2023</last_update_submitted>
  <last_update_submitted_qc>March 13, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">April 10, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Conjunctivitis</mesh_term>
    <mesh_term>Conjunctivitis, Allergic</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>Undecided</sharing_ipd>
  </patient_data>
  <provided_document_section>
    <provided_document>
      <document_type>Study Protocol</document_type>
      <document_has_protocol>Yes</document_has_protocol>
      <document_has_icf>No</document_has_icf>
      <document_has_sap>No</document_has_sap>
      <document_date>January 13, 2017</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/83/NCT02978183/Prot_002.pdf</document_url>
    </provided_document>
    <provided_document>
      <document_type>Statistical Analysis Plan</document_type>
      <document_has_protocol>No</document_has_protocol>
      <document_has_icf>No</document_has_icf>
      <document_has_sap>Yes</document_has_sap>
      <document_date>January 5, 2017</document_date>
      <document_url>https://ClinicalTrials.gov/ProvidedDocs/83/NCT02978183/SAP_003.pdf</document_url>
    </provided_document>
  </provided_document_section>

  <clinical_results>

    <participant_flow>
      <group_list>
        <group group_id="P1">
          <title>Group 1</title>
          <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
        </group>
        <group group_id="P2">
          <title>Group 2</title>
          <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
        </group>
      </group_list>
      <period_list>
        <period>
          <title>Overall Study</title>
          <milestone_list>
            <milestone>
              <title>STARTED</title>
              <participants_list>
                <participants group_id="P1" count="34"/>
                <participants group_id="P2" count="36"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="34"/>
                <participants group_id="P2" count="36"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>NOT COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="0"/>
              </participants_list>
            </milestone>
          </milestone_list>
        </period>
      </period_list>
    </participant_flow>

    <baseline>
      <group_list>
        <group group_id="B1">
          <title>Group 1</title>
          <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
        </group>
        <group group_id="B2">
          <title>Group 2</title>
          <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
        </group>
        <group group_id="B3">
          <title>Total</title>
          <description>Total of all reporting groups</description>
        </group>
      </group_list>
      <analyzed_list>
        <analyzed>
          <units>Participants</units>
          <scope>Overall</scope>
          <count_list>
            <count group_id="B1" value="34"/>
            <count group_id="B2" value="36"/>
            <count group_id="B3" value="70"/>
          </count_list>
        </analyzed>
      </analyzed_list>
      <measure_list>
        <measure>
          <title>Age</title>
          <units>years</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="43.5" spread="13.44"/>
                    <measurement group_id="B2" value="47" spread="13.98"/>
                    <measurement group_id="B3" value="45.3" spread="13.74"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Sex: Female, Male</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>Female</title>
                  <measurement_list>
                    <measurement group_id="B1" value="19"/>
                    <measurement group_id="B2" value="22"/>
                    <measurement group_id="B3" value="41"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Male</title>
                  <measurement_list>
                    <measurement group_id="B1" value="15"/>
                    <measurement group_id="B2" value="14"/>
                    <measurement group_id="B3" value="29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Ethnicity (NIH/OMB)</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>Hispanic or Latino</title>
                  <measurement_list>
                    <measurement group_id="B1" value="4"/>
                    <measurement group_id="B2" value="4"/>
                    <measurement group_id="B3" value="8"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Not Hispanic or Latino</title>
                  <measurement_list>
                    <measurement group_id="B1" value="30"/>
                    <measurement group_id="B2" value="32"/>
                    <measurement group_id="B3" value="62"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Unknown or Not Reported</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Race (NIH/OMB)</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>American Indian or Alaska Native</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Asian</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="1"/>
                    <measurement group_id="B3" value="1"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Native Hawaiian or Other Pacific Islander</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="1"/>
                    <measurement group_id="B3" value="1"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Black or African American</title>
                  <measurement_list>
                    <measurement group_id="B1" value="9"/>
                    <measurement group_id="B2" value="10"/>
                    <measurement group_id="B3" value="19"/>
                  </measurement_list>
                </category>
                <category>
                  <title>White</title>
                  <measurement_list>
                    <measurement group_id="B1" value="25"/>
                    <measurement group_id="B2" value="24"/>
                    <measurement group_id="B3" value="49"/>
                  </measurement_list>
                </category>
                <category>
                  <title>More than one race</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Unknown or Not Reported</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Iris Color</title>
          <units>eyes</units>
          <param>Number</param>
          <class_list>
            <class>
              <title>Black</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Blue</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="10"/>
                    <measurement group_id="B2" value="20"/>
                    <measurement group_id="B3" value="30"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Brown</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="42"/>
                    <measurement group_id="B2" value="44"/>
                    <measurement group_id="B3" value="86"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Hazel</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="8"/>
                    <measurement group_id="B2" value="2"/>
                    <measurement group_id="B3" value="10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Green</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="8"/>
                    <measurement group_id="B2" value="6"/>
                    <measurement group_id="B3" value="14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Other</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Allergen Disposition</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>Dust Mite</title>
                  <measurement_list>
                    <measurement group_id="B1" value="18"/>
                    <measurement group_id="B2" value="16"/>
                    <measurement group_id="B3" value="34"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Dog Dander</title>
                  <measurement_list>
                    <measurement group_id="B1" value="4"/>
                    <measurement group_id="B2" value="5"/>
                    <measurement group_id="B3" value="9"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Cockroach</title>
                  <measurement_list>
                    <measurement group_id="B1" value="1"/>
                    <measurement group_id="B2" value="4"/>
                    <measurement group_id="B3" value="5"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Cat Dander</title>
                  <measurement_list>
                    <measurement group_id="B1" value="11"/>
                    <measurement group_id="B2" value="11"/>
                    <measurement group_id="B3" value="22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </measure_list>
    </baseline>

    <outcome_list>
      <outcome>
        <type>Primary</type>
        <title>Ocular Itching</title>
        <description>Ocular itching evaluated by the subject. Ocular itching was evaluated on a 0-4 scale (with half unit increments allowed). Lower scores indicated less itching.</description>
        <time_frame>Day 7 and 8</time_frame>
        <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Ocular Itching</title>
          <description>Ocular itching evaluated by the subject. Ocular itching was evaluated on a 0-4 scale (with half unit increments allowed). Lower scores indicated less itching.</description>
          <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="33"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.508" spread="0.8373"/>
                    <measurement group_id="O2" value="0.139" spread="0.3131"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 5 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.485" spread="0.9533"/>
                    <measurement group_id="O2" value="2.535" spread="1.1070"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 7 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.559" spread="0.9887"/>
                    <measurement group_id="O2" value="2.576" spread="1.1113"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.434" spread="0.9320"/>
                    <measurement group_id="O2" value="2.458" spread="1.1124"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.154" spread="0.9415"/>
                    <measurement group_id="O2" value="2.181" spread="1.1520"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.838" spread="0.9960"/>
                    <measurement group_id="O2" value="1.910" spread="1.1482"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.529" spread="0.9103"/>
                    <measurement group_id="O2" value="1.722" spread="1.1707"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.346" spread="0.9435"/>
                    <measurement group_id="O2" value="1.583" spread="1.1164"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.449" spread="0.7405"/>
                    <measurement group_id="O2" value="0.167" spread="0.3827"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 5 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.816" spread="0.8968"/>
                    <measurement group_id="O2" value="2.618" spread="0.9847"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 7 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.787" spread="0.9316"/>
                    <measurement group_id="O2" value="2.625" spread="0.9865"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.588" spread="0.9903"/>
                    <measurement group_id="O2" value="2.604" spread="1.0357"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.309" spread="0.9654"/>
                    <measurement group_id="O2" value="2.299" spread="1.0804"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.081" spread="0.9389"/>
                    <measurement group_id="O2" value="1.986" spread="1.1354"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.765" spread="0.9573"/>
                    <measurement group_id="O2" value="1.819" spread="1.1158"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.493" spread="0.9262"/>
                    <measurement group_id="O2" value="1.590" spread="1.1167"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.0882</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 5 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8032</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 7 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9003</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9523</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9071</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7509</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2824</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4017</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4497</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.1650</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 5 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3494</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 7 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4781</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9847</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9731</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6984</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6265</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7848</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5789</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Conjunctival Redness</title>
        <description>Conjunctival redness evaluated by the investigator. Conjunctival redness was evaluated on a 0-4 scale (with half unit increments allowed). Lower scores indicated less redness.</description>
        <time_frame>Day 7 and 8</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Conjunctival Redness</title>
          <description>Conjunctival redness evaluated by the investigator. Conjunctival redness was evaluated on a 0-4 scale (with half unit increments allowed). Lower scores indicated less redness.</description>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.103" spread="0.7541"/>
                    <measurement group_id="O2" value="1.028" spread="0.5818"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.125" spread="0.8817"/>
                    <measurement group_id="O2" value="1.958" spread="0.8814"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.897" spread="0.9714"/>
                    <measurement group_id="O2" value="1.882" spread="0.9073"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.926" spread="1.0308"/>
                    <measurement group_id="O2" value="1.771" spread="0.8481"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.875" spread="1.0005"/>
                    <measurement group_id="O2" value="1.743" spread="0.8377"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.816" spread="1.0323"/>
                    <measurement group_id="O2" value="1.681" spread="0.8775"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, Pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.912" spread="0.6682"/>
                    <measurement group_id="O2" value="0.819" spread="0.4766"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.963" spread="0.7909"/>
                    <measurement group_id="O2" value="1.917" spread="0.7319"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.963" spread="0.8075"/>
                    <measurement group_id="O2" value="2.111" spread="0.7870"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.882" spread="0.8101"/>
                    <measurement group_id="O2" value="1.951" spread="0.8036"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.735" spread="0.8549"/>
                    <measurement group_id="O2" value="1.785" spread="0.8241"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.596" spread="0.8791"/>
                    <measurement group_id="O2" value="1.625" spread="0.7476"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8165</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6590</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7455</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9212</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9509</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7897</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3183</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7604</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7343</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.1530</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3307</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3399</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5137</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9962</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Ciliary Redness</title>
        <description>Ciliary redness evaluated by the investigator. Ciliary redness was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less redness.</description>
        <time_frame>Day 7 and 8</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Ciliary Redness</title>
          <description>Ciliary redness evaluated by the investigator. Ciliary redness was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less redness.</description>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.912" spread="0.6243"/>
                    <measurement group_id="O2" value="0.750" spread="0.5445"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.838" spread="0.8368"/>
                    <measurement group_id="O2" value="1.799" spread="0.8341"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.691" spread="0.9925"/>
                    <measurement group_id="O2" value="1.729" spread="0.8353"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.713" spread="0.9417"/>
                    <measurement group_id="O2" value="1.625" spread="0.8420"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.654" spread="0.9150"/>
                    <measurement group_id="O2" value="1.583" spread="0.7488"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.603" spread="0.9869"/>
                    <measurement group_id="O2" value="1.493" spread="0.8608"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.581" spread="0.6053"/>
                    <measurement group_id="O2" value="0.521" spread="0.4487"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.691" spread="0.8189"/>
                    <measurement group_id="O2" value="1.743" spread="0.7058"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.699" spread="0.7804"/>
                    <measurement group_id="O2" value="1.931" spread="0.7310"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.625" spread="0.8556"/>
                    <measurement group_id="O2" value="1.792" spread="0.7688"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.463" spread="0.9027"/>
                    <measurement group_id="O2" value="1.569" spread="0.7806"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.346" spread="0.8528"/>
                    <measurement group_id="O2" value="1.458" spread="0.8007"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3259</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9785</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5112</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7771</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6232</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8895</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8974</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9604</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5301</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.0386</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.1034</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.0985</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2342</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3016</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Episcleral Redness</title>
        <description>Episcleral redness evaluated by the investigator. Episcleral redness was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less redness.</description>
        <time_frame>Day 7 and 8</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Episcleral Redness</title>
          <description>Episcleral redness evaluated by the investigator. Episcleral redness was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less redness.</description>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.029" spread="0.6622"/>
                    <measurement group_id="O2" value="0.910" spread="0.5579"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.868" spread="0.8217"/>
                    <measurement group_id="O2" value="1.819" spread="0.8401"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.757" spread="0.9283"/>
                    <measurement group_id="O2" value="1.778" spread="0.8468"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.787" spread="0.9656"/>
                    <measurement group_id="O2" value="1.701" spread="0.8036"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.721" spread="0.9939"/>
                    <measurement group_id="O2" value="1.618" spread="0.7500"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.669" spread="1.0275"/>
                    <measurement group_id="O2" value="1.583" spread="0.8345"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.507" spread="0.5822"/>
                    <measurement group_id="O2" value="0.424" spread="0.4544"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.735" spread="0.8210"/>
                    <measurement group_id="O2" value="1.708" spread="0.6827"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.706" spread="0.8404"/>
                    <measurement group_id="O2" value="1.896" spread="0.7055"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.647" spread="0.8144"/>
                    <measurement group_id="O2" value="1.701" spread="0.7508"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.412" spread="0.8680"/>
                    <measurement group_id="O2" value="1.583" spread="0.7488"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.353" spread="0.8575"/>
                    <measurement group_id="O2" value="1.347" spread="0.7495"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4927</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8686</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5772</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9700</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7516</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9532</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7522</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6804</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6267</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.0976</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4687</p_value>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.0421</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6085</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9634</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Chemosis</title>
        <description>Chemosis evaluated by the investigator. Chemosis was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less chemosis.</description>
        <time_frame>Day 7 and 8</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Chemosis</title>
          <description>Chemosis evaluated by the investigator. Chemosis was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less chemosis.</description>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.390" spread="0.3703"/>
                    <measurement group_id="O2" value="0.465" spread="0.3787"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.765" spread="0.4306"/>
                    <measurement group_id="O2" value="0.840" spread="0.4711"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.669" spread="0.5391"/>
                    <measurement group_id="O2" value="0.708" spread="0.4762"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.691" spread="0.5709"/>
                    <measurement group_id="O2" value="0.778" spread="0.4259"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.691" spread="0.6001"/>
                    <measurement group_id="O2" value="0.785" spread="0.5146"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.676" spread="0.6047"/>
                    <measurement group_id="O2" value="0.757" spread="0.4075"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.081" spread="0.2280"/>
                    <measurement group_id="O2" value="0.104" spread="0.1925"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.574" spread="0.6262"/>
                    <measurement group_id="O2" value="0.674" spread="0.4994"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.632" spread="0.7288"/>
                    <measurement group_id="O2" value="0.764" spread="0.4265"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.684" spread="0.7792"/>
                    <measurement group_id="O2" value="0.708" spread="0.4571"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.566" spread="0.7444"/>
                    <measurement group_id="O2" value="0.590" spread="0.5674"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.551" spread="0.8137"/>
                    <measurement group_id="O2" value="0.493" spread="0.6196"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3322</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 Minutes Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8026</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9981</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5645</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5455</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6980</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6115</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4528</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7551</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5318</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9748</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7706</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3414</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4361</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Eyelid Swelling</title>
        <description>Eyelid swelling evaluated by the subject. Eyelid swelling was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less swelling.</description>
        <time_frame>Day 7 and 8</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Eyelid Swelling</title>
          <description>Eyelid swelling evaluated by the subject. Eyelid swelling was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less swelling.</description>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.45" spread="0.711"/>
                    <measurement group_id="O2" value="0.22" spread="0.404"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.22" spread="0.889"/>
                    <measurement group_id="O2" value="1.39" spread="0.871"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.25" spread="0.915"/>
                    <measurement group_id="O2" value="1.33" spread="0.837"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.06" spread="0.776"/>
                    <measurement group_id="O2" value="1.25" spread="0.841"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.96" spread="0.711"/>
                    <measurement group_id="O2" value="1.22" spread="0.857"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.79" spread="0.780"/>
                    <measurement group_id="O2" value="0.97" spread="0.836"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.41" spread="0.621"/>
                    <measurement group_id="O2" value="0.26" spread="0.500"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.35" spread="0.744"/>
                    <measurement group_id="O2" value="1.21" spread="0.873"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.29" spread="0.740"/>
                    <measurement group_id="O2" value="1.19" spread="0.881"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.12" spread="0.817"/>
                    <measurement group_id="O2" value="1.11" spread="0.887"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.94" spread="0.766"/>
                    <measurement group_id="O2" value="1.10" spread="0.893"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.81" spread="0.728"/>
                    <measurement group_id="O2" value="0.89" spread="0.887"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.0603</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4857</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9815</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6213</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.1831</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6489</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2622</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2397</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3202</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2663</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5672</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5055</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8143</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6901</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Tearing/Watery Eyes</title>
        <description>Tearing evaluated by the subject. Tearing was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less tearing.</description>
        <time_frame>Day 7 and 8</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Tearing/Watery Eyes</title>
          <description>Tearing evaluated by the subject. Tearing was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less tearing.</description>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.38" spread="0.707"/>
                    <measurement group_id="O2" value="0.21" spread="0.437"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.15" spread="0.966"/>
                    <measurement group_id="O2" value="1.38" spread="1.024"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.88" spread="1.038"/>
                    <measurement group_id="O2" value="1.22" spread="1.003"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.72" spread="0.898"/>
                    <measurement group_id="O2" value="1.07" spread="0.965"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.71" spread="0.930"/>
                    <measurement group_id="O2" value="0.94" spread="1.034"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.65" spread="0.875"/>
                    <measurement group_id="O2" value="0.85" spread="0.909"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.37" spread="0.810"/>
                    <measurement group_id="O2" value="0.28" spread="0.553"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.07" spread="1.074"/>
                    <measurement group_id="O2" value="1.15" spread="0.970"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.04" spread="1.090"/>
                    <measurement group_id="O2" value="1.13" spread="0.929"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.87" spread="0.864"/>
                    <measurement group_id="O2" value="1.01" spread="0.906"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.76" spread="0.809"/>
                    <measurement group_id="O2" value="1.00" spread="0.956"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.65" spread="0.803"/>
                    <measurement group_id="O2" value="0.88" spread="0.952"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4032</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2946</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2863</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.0891</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5347</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3733</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2506</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8667</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7640</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8008</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4729</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4742</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2922</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3657</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Rhinorrhea</title>
        <description>Rhinorrhea evaluated by the subject. Rhinorrhea was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
        <time_frame>Day 7 and 8</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Rhinorrhea</title>
          <description>Rhinorrhea evaluated by the subject. Rhinorrhea was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.33" spread="0.595"/>
                    <measurement group_id="O2" value="0.19" spread="0.525"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.35" spread="1.152"/>
                    <measurement group_id="O2" value="1.47" spread="1.134"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.18" spread="0.904"/>
                    <measurement group_id="O2" value="1.31" spread="1.142"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.97" spread="0.870"/>
                    <measurement group_id="O2" value="0.97" spread="1.082"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.85" spread="0.821"/>
                    <measurement group_id="O2" value="0.89" spread="1.090"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.85" spread="0.784"/>
                    <measurement group_id="O2" value="0.94" spread="1.068"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.29" spread="0.579"/>
                    <measurement group_id="O2" value="0.22" spread="0.591"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.29" spread="0.938"/>
                    <measurement group_id="O2" value="1.39" spread="1.225"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.26" spread="0.963"/>
                    <measurement group_id="O2" value="1.31" spread="1.283"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.09" spread="0.933"/>
                    <measurement group_id="O2" value="1.08" spread="1.156"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.00" spread="0.853"/>
                    <measurement group_id="O2" value="0.92" spread="1.180"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.94" spread="0.776"/>
                    <measurement group_id="O2" value="0.83" spread="1.108"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6600</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6877</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3340</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7874</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3812</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6987</p_value>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6832</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8521</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7516</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6252</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8321</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8173</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5445</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6810</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Nasal Pruritus</title>
        <description>Nasal Pruritus evaluated by the subject. Nasal pruritus was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
        <time_frame>Day 7 and 8</time_frame>
        <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Nasal Pruritus</title>
          <description>Nasal Pruritus evaluated by the subject. Nasal pruritus was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
          <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="33"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.30" spread="0.467"/>
                    <measurement group_id="O2" value="0.06" spread="0.232"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.03" spread="1.141"/>
                    <measurement group_id="O2" value="1.11" spread="1.116"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.91" spread="0.965"/>
                    <measurement group_id="O2" value="1.03" spread="1.082"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.76" spread="0.923"/>
                    <measurement group_id="O2" value="0.89" spread="0.950"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.76" spread="0.890"/>
                    <measurement group_id="O2" value="0.83" spread="0.971"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.65" spread="0.774"/>
                    <measurement group_id="O2" value="0.75" spread="0.967"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.24" spread="0.554"/>
                    <measurement group_id="O2" value="0.14" spread="0.487"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.03" spread="1.167"/>
                    <measurement group_id="O2" value="0.94" spread="1.145"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.03" spread="1.087"/>
                    <measurement group_id="O2" value="0.83" spread="1.082"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.91" spread="1.111"/>
                    <measurement group_id="O2" value="0.69" spread="1.009"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.68" spread="0.912"/>
                    <measurement group_id="O2" value="0.69" spread="1.009"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.59" spread="0.821"/>
                    <measurement group_id="O2" value="0.64" spread="1.018"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.0111</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3391</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.2390</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3068</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4914</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5185</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5262</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6098</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8849</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6941</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5728</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5931</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7513</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7297</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Ear or Palate Pruritus</title>
        <description>Ear or palate pruritus evaluated by the subject. Ear or palate pruritus was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
        <time_frame>Day 7 and 8</time_frame>
        <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Ear or Palate Pruritus</title>
          <description>Ear or palate pruritus evaluated by the subject. Ear or palate pruritus was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
          <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="33"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.33" spread="0.595"/>
                    <measurement group_id="O2" value="0.19" spread="0.401"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.26" spread="1.355"/>
                    <measurement group_id="O2" value="1.22" spread="1.245"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.18" spread="1.193"/>
                    <measurement group_id="O2" value="1.11" spread="1.214"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.00" spread="1.073"/>
                    <measurement group_id="O2" value="1.08" spread="1.105"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.91" spread="0.965"/>
                    <measurement group_id="O2" value="0.94" spread="1.094"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.88" spread="0.808"/>
                    <measurement group_id="O2" value="0.83" spread="0.971"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.06" spread="0.239"/>
                    <measurement group_id="O2" value="0.19" spread="0.401"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.18" spread="1.336"/>
                    <measurement group_id="O2" value="1.33" spread="1.352"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.15" spread="1.282"/>
                    <measurement group_id="O2" value="1.28" spread="1.344"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.12" spread="1.274"/>
                    <measurement group_id="O2" value="1.19" spread="1.283"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.00" spread="1.181"/>
                    <measurement group_id="O2" value="1.08" spread="1.204"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.00" spread="1.128"/>
                    <measurement group_id="O2" value="0.97" spread="1.253"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.1259</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9234</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8816</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5703</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5428</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7454</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8195</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.0909</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4881</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3391</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6065</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.3393</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8364</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8858</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Nasal Congestion</title>
        <description>Nasal congestion evaluated by the subject. Nasal congestion was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
        <time_frame>Day 7 and 8</time_frame>
        <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Nasal Congestion</title>
          <description>Nasal congestion evaluated by the subject. Nasal congestion was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.</description>
          <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
          <units>score on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="33"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.67" spread="0.816"/>
                    <measurement group_id="O2" value="0.42" spread="0.906"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.44" spread="1.160"/>
                    <measurement group_id="O2" value="1.47" spread="1.230"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.41" spread="1.048"/>
                    <measurement group_id="O2" value="1.36" spread="1.099"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.24" spread="0.987"/>
                    <measurement group_id="O2" value="1.22" spread="1.072"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.15" spread="0.989"/>
                    <measurement group_id="O2" value="1.22" spread="1.174"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.12" spread="1.008"/>
                    <measurement group_id="O2" value="1.17" spread="1.159"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="0.47" spread="0.662"/>
                    <measurement group_id="O2" value="0.33" spread="0.717"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.29" spread="1.060"/>
                    <measurement group_id="O2" value="1.36" spread="1.199"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.35" spread="1.070"/>
                    <measurement group_id="O2" value="1.39" spread="1.293"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.26" spread="1.024"/>
                    <measurement group_id="O2" value="1.28" spread="1.279"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.18" spread="0.968"/>
                    <measurement group_id="O2" value="1.28" spread="1.210"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.15" spread="1.048"/>
                    <measurement group_id="O2" value="1.22" spread="1.222"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8818</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8679</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7856</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7507</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8189</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9206</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.9591</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: Pre-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.5302</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7591</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8978</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7179</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7262</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 Minutes Post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.8275</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: All Post-CAC Time Points</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.6180</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>ANCOVA</method>
          </analysis>
        </analysis_list>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Nasal Composite Score</title>
        <description>A composite score of presence or absence of at least one nasal symptom evaluated by the subject</description>
        <time_frame>Day 7 and 8</time_frame>
        <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
        <group_list>
          <group group_id="O1">
            <title>Group 1</title>
            <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
          <group group_id="O2">
            <title>Group 2</title>
            <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
          </group>
        </group_list>
        <measure>
          <title>Nasal Composite Score</title>
          <description>A composite score of presence or absence of at least one nasal symptom evaluated by the subject</description>
          <population>Pre-Conjunctival Allergen Challenge not evaluated in subject 1-011 on visit 5B</population>
          <units>Participants</units>
          <param>Count of Participants</param>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="34"/>
                <count group_id="O2" value="36"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Day 7, Pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="33"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="11"/>
                    <measurement group_id="O2" value="23"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="22"/>
                    <measurement group_id="O2" value="13"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="2"/>
                    <measurement group_id="O2" value="2"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="32"/>
                    <measurement group_id="O2" value="34"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="2"/>
                    <measurement group_id="O2" value="2"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="32"/>
                    <measurement group_id="O2" value="34"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="3"/>
                    <measurement group_id="O2" value="3"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="31"/>
                    <measurement group_id="O2" value="33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="5"/>
                    <measurement group_id="O2" value="4"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="29"/>
                    <measurement group_id="O2" value="32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 7, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="4"/>
                    <measurement group_id="O2" value="4"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="30"/>
                    <measurement group_id="O2" value="32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, pre-Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="18"/>
                    <measurement group_id="O2" value="26"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="16"/>
                    <measurement group_id="O2" value="10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 10 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="1"/>
                    <measurement group_id="O2" value="2"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="33"/>
                    <measurement group_id="O2" value="34"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 15 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="2"/>
                    <measurement group_id="O2" value="3"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="32"/>
                    <measurement group_id="O2" value="33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 20 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="4"/>
                    <measurement group_id="O2" value="4"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="30"/>
                    <measurement group_id="O2" value="32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 25 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="2"/>
                    <measurement group_id="O2" value="5"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="32"/>
                    <measurement group_id="O2" value="31"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Day 8, 30 Minutes Post Conjunctival Allergen Challenge</title>
              <analyzed_list>
                <analyzed>
                  <units>Participants</units>
                  <scope>Class</scope>
                  <count_list>
                    <count group_id="O1" value="34"/>
                    <count group_id="O2" value="36"/>
                  </count_list>
                </analyzed>
              </analyzed_list>
              <category_list>
                <category>
                  <title>Absent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="3"/>
                    <measurement group_id="O2" value="6"/>
                  </measurement_list>
                </category>
                <category>
                  <title>PResent</title>
                  <measurement_list>
                    <measurement group_id="O1" value="31"/>
                    <measurement group_id="O2" value="30"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <analysis_list>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 10 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>&gt;0.9999</p_value>
            <p_value_desc>Adjustments for multiplicity were not employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 15 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>&gt;0.9999</p_value>
            <p_value_desc>Adjustments for multiplicity will not be employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 20 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>&gt;0.9999</p_value>
            <p_value_desc>Adjustments for multiplicity will not be employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 25 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.7312</p_value>
            <p_value_desc>Adjustments for multiplicity will not be employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 7: 30 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>&gt;0.9999</p_value>
            <p_value_desc>Adjustments for multiplicity will not be employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 10 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>&gt;0.9999</p_value>
            <p_value_desc>Adjustments for multiplicity will not be employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 15 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>&gt;0.9999</p_value>
            <p_value_desc>Adjustments for multiplicity will not be employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 20 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>&gt;0.9999</p_value>
            <p_value_desc>Adjustments for multiplicity will not be employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 25 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4297</p_value>
            <p_value_desc>Adjustments for multiplicity will not be employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
          <analysis>
            <group_id_list>
              <group_id>O1</group_id>
              <group_id>O2</group_id>
            </group_id_list>
            <groups_desc>Day 8: 30 minutes post-CAC</groups_desc>
            <non_inferiority_type>Superiority</non_inferiority_type>
            <p_value>0.4791</p_value>
            <p_value_desc>Adjustments for multiplicity will not be employed</p_value_desc>
            <method>Fisher Exact</method>
          </analysis>
        </analysis_list>
      </outcome>
    </outcome_list>

    <reported_events>
      <time_frame>Adverse events were assessed for subjects over a period of 8 days during active treatment. If an AE was unresolved at the final study visit Investigators were instructed to follow-up with subjects until the AE resolved or they were lost to follow-up. If the patient is lost to follow-up, the Investigator should make 3 reasonable attempts to contact the patient via telephone, post, or certified mail.</time_frame>
      <group_list>
        <group group_id="E1">
          <title>Group 1</title>
          <description>1X ST266 dosed 4 times a day for 8 days&#xD;
ST266: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
        </group>
        <group group_id="E2">
          <title>Group 2</title>
          <description>Placebo dosed 4 times a day for 8 days&#xD;
Saline (0.9% NaCl): One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.</description>
        </group>
      </group_list>
      <serious_events>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, all-cause mortality</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="34"/>
                <counts group_id="E2" subjects_affected="0" subjects_at_risk="36"/>
              </event>
              <event>
                <sub_title>Total, serious adverse events</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="34"/>
                <counts group_id="E2" subjects_affected="0" subjects_at_risk="36"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </serious_events>
      <other_events>
        <frequency_threshold>0</frequency_threshold>
        <default_assessment>Non-systematic Assessment</default_assessment>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, other adverse events</sub_title>
                <counts group_id="E1" subjects_affected="2" subjects_at_risk="34"/>
                <counts group_id="E2" subjects_affected="3" subjects_at_risk="36"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Eye disorders</title>
            <event_list>
              <event>
                <sub_title>Visual Acuity Reduced</sub_title>
                <assessment>Systematic Assessment</assessment>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="34"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="36"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Infections and infestations</title>
            <event_list>
              <event>
                <sub_title>Infected Bite</sub_title>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="34"/>
                <counts group_id="E2" events="0" subjects_affected="0" subjects_at_risk="36"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Nervous system disorders</title>
            <event_list>
              <event>
                <sub_title>Headache</sub_title>
                <counts group_id="E1" events="0" subjects_affected="0" subjects_at_risk="34"/>
                <counts group_id="E2" events="3" subjects_affected="3" subjects_at_risk="36"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </other_events>
    </reported_events>

    <certain_agreements>
      <pi_employee>Principal Investigators are NOT employed by the organization sponsoring the study.</pi_employee>
      <restrictive_agreement>There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed. </restrictive_agreement>
    </certain_agreements>
    <point_of_contact>
      <name_or_title>David Steed, MD</name_or_title>
      <organization>Noveome Biotherapeutics, Inc</organization>
      <phone>4124029913</phone>
      <email>dsteed@noveome.com</email>
    </point_of_contact>
  </clinical_results>
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02978183
org study id: ST266-AC-201
nct id: NCT02978183
lead sponsor: 
has dmc: No
The purpose of this study is to evaluate the efficacy of ST266 ophthalmic drops compared to
      placebo for the treatment of the signs and symptoms of allergic conjunctivitis.
The study is a multi-center, double-masked, randomized, placebo-controlled, modified
      conjunctival allergen challenge (CAC) model. The primary endpoints of ocular itching and
      conjunctival redness will be evaluated at the subject's final visit. Subjects who meet
      inclusion criteria will be randomized to one of two treatment groups (1:1). Randomization
      will be stratified by average post-CAC itching scores at baseline.

      Subjects will be evaluated at baseline and on Days 6, 7 and 8.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Double (Participant, Investigator)
measure: Ocular Itching
time frame: Day 7 and 8
description: Ocular itching evaluated by the subject. Ocular itching was evaluated on a 0-4 scale (with half unit increments allowed). Lower scores indicated less itching.
measure: Conjunctival Redness
time frame: Day 7 and 8
description: Conjunctival redness evaluated by the investigator. Conjunctival redness was evaluated on a 0-4 scale (with half unit increments allowed). Lower scores indicated less redness.
measure: Ciliary Redness
time frame: Day 7 and 8
description: Ciliary redness evaluated by the investigator. Ciliary redness was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less redness.
measure: Episcleral Redness
time frame: Day 7 and 8
description: Episcleral redness evaluated by the investigator. Episcleral redness was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less redness.
measure: Chemosis
time frame: Day 7 and 8
description: Chemosis evaluated by the investigator. Chemosis was evaluated on a 0-4 scale (with half unit increments allowed). A lower score was indicative of less chemosis.
measure: Eyelid Swelling
time frame: Day 7 and 8
description: Eyelid swelling evaluated by the subject. Eyelid swelling was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less swelling.
measure: Tearing/Watery Eyes
time frame: Day 7 and 8
description: Tearing evaluated by the subject. Tearing was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less tearing.
measure: Rhinorrhea
time frame: Day 7 and 8
description: Rhinorrhea evaluated by the subject. Rhinorrhea was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.
measure: Nasal Pruritus
time frame: Day 7 and 8
description: Nasal Pruritus evaluated by the subject. Nasal pruritus was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.
measure: Ear or Palate Pruritus
time frame: Day 7 and 8
description: Ear or palate pruritus evaluated by the subject. Ear or palate pruritus was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.
measure: Nasal Congestion
time frame: Day 7 and 8
description: Nasal congestion evaluated by the subject. Nasal congestion was evaluated on a 0-4 scale in which 0.5 unit increments were not allowed. A lower score was indicative of less severity.
measure: Nasal Composite Score
time frame: Day 7 and 8
description: A composite score of presence or absence of at least one nasal symptom evaluated by the subject
arm group label: Group 1
arm group type: Active Comparator
description: 1X ST266 dosed 4 times a day for 8 days
arm group label: Group 2
arm group type: Placebo Comparator
description: Placebo dosed 4 times a day for 8 days
intervention type: Biological
intervention name: ST266
description: One (1) drop of 1X ST266 ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.
arm group label: Group 1
intervention type: Drug
intervention name: Saline (0.9% NaCl)
description: One (1) drop of saline ophthalmic eye drops will be administered to each eye 4 times a day for 8 days.
arm group label: Group 2
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
facility: 
facility: 
country: United States
responsible party type: Sponsor
mesh term: Conjunctivitis
mesh term: Conjunctivitis, Allergic
sharing ipd: Undecided
provided document: 
provided document: 
participant flow: 
baseline: 
outcome list: 
reported events: 
certain agreements: 
point of contact: 