<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT03006250</url>
  </required_header>
  <id_info>
    <org_study_id>15072016</org_study_id>
    <nct_id>NCT03006250</nct_id>
  </id_info>
  <brief_title>The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia</brief_title>
  <official_title>The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia: A Prospective Randomized Double-blinded Control Study</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Chiang Mai University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Chiang Mai University</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The effects of desflurane versus sevoflurane in adult patients undergoing LMA anesthesia on&#xD;
      respiratory events during a less than 2-hour elective surgery.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Laryngeal Mask Airway (LMA) anesthesia is generally performed for ambulatory surgery to avoid&#xD;
      the use of neuromuscular blocking agents and to facilitate rapid emergence from anesthesia.&#xD;
      Inhaled anesthetics are simply and popularly used during maintenance of anesthesia. The two&#xD;
      most recent volatile anesthetic agents, desflurane and sevoflurane, are the two most commonly&#xD;
      used in clinical practice for an ambulatory setting.&#xD;
&#xD;
      Desflurane is the volatile agent with low blood: gas partition coefficient (0.42).&#xD;
      Desflurane's uptake and elimination from the body of a patient are rapid, which results in a&#xD;
      fast onset of anesthesia and a fast recovery from anesthesia. This property provides&#xD;
      desflurane as an ideal agent for the ambulatory anesthesia. However, its pungent odor is&#xD;
      concerned to irritate the upper airway and may cause significant respiratory complications.&#xD;
      Sevoflurane has a blood: gas partition coefficient of 0.65, which is slightly greater than&#xD;
      desflurane. The major advantage over desflurane is the better scent. It is considered to be&#xD;
      less airway irritation in LMA anesthesia with smooth induction and recovery.&#xD;
&#xD;
      The limitation of desflurane on its odor leads to a controversy if desflurane is similar to&#xD;
      or worse than sevoflurane for LMA anesthesia. This is non-inferiority study designed to&#xD;
      compare the occurrence of respiratory complications between desflurane and sevoflurane during&#xD;
      LMA anesthesia.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date>August 2016</start_date>
  <completion_date type="Anticipated">July 2019</completion_date>
  <primary_completion_date type="Anticipated">July 2019</primary_completion_date>
  <phase>Phase 4</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Diagnostic</primary_purpose>
    <masking>Triple (Participant, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Occurrence of respiratory complications</measure>
    <time_frame>From the beginning of operation until 30 minutes after the operation</time_frame>
    <description>Respiratory complications are coughing, breath holding, laryngospasm, bronchospasm, and desaturation</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Time of eye opening</measure>
    <time_frame>Within 30 minutes after the end of operation</time_frame>
    <description>It is the time from discontinuation of anesthetic to the eye opening on verbal command.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Time to follow motor command</measure>
    <time_frame>Within 30 minutes after the end of operation</time_frame>
    <description>It is the time from discontinuation of anesthetic to hand squeezing.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Time of LMA removal</measure>
    <time_frame>Within 30 minutes after the end of operation</time_frame>
    <description>It is the time from discontinuation of anesthetic to removal of LMA.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Frequency of postoperative nausea and vomiting (PONV)</measure>
    <time_frame>Within 2 hours after operation</time_frame>
    <description>It is a number of patients with PONV in the early post-anesthetic period.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes of blood pressure during anesthesia</measure>
    <time_frame>Every 15 minutes, from the beginning of operation until 30 minutes after the operation</time_frame>
    <description>Non-invasive blood pressure will be recorded at the beginning of anesthesia, every 15 minutes during anesthetic maintenance, and at the time of LMA removal.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Changes of heart rate during anesthesia</measure>
    <time_frame>Every 15 minutes, from the beginning of operation until 30 minutes after the operation</time_frame>
    <description>Heart rate will be recorded at the beginning of anesthesia, every 15 minutes during anesthetic maintenance, and at the time of LMA removal.</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Time to achieve a satisfied Modified Aldrete score</measure>
    <time_frame>Within 2 hours after operation</time_frame>
    <description>It is the time that the patient is ready to be discharged from post-anesthetic care unit.</description>
  </other_outcome>
  <other_outcome>
    <measure>Number of Patients with high satisfaction to anesthesia</measure>
    <time_frame>At 12-24 hour after surgery</time_frame>
    <description>The satisfaction is graded using a 5-point rating scale.</description>
  </other_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">220</enrollment>
  <condition>Anesthesia; Adverse Effect</condition>
  <condition>Laryngeal Masks</condition>
  <condition>Respiratory System Abnormalities</condition>
  <arm_group>
    <arm_group_label>Desflurane</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Desflurane group: The rule of 24 will be applied, which means that the fresh gas flow (l/ min) multiplied by volume percent of desflurane must not exceed 24. Therefore, once the patients return of spontaneous ventilation, an anesthesiologist turns on oxygen 1 l/ min, nitrous oxide 1 l/ min, and desflurane 12 vol% for 1-2 minutes. When the end-tidal desflurane reaches 3-3.5% (approximately 0.5 MAC), the anesthesiologist will decrease oxygen and nitrous oxide to each 0.5 l/ min and desflurane to 6 vol% (1 MAC). Desflurane concentration will be adjusted to maintain the end-tidal desflurane around 3-6% (0.5-1 MAC).</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Sevoflurane</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Sevoflurane group: The oxygen and nitrous oxide each 1 l/min will be turned on with sevoflurane 4 vol% for 1-2 minutes or until the end-tidal sevoflurane reach 1-1.2% (approximately 0.5 MAC). After that, the flow of oxygen and nitrous oxide is reduced to each 0.5 l/ min and concentration dial of sevoflurane is set to 2 vol% (1 MAC). During the operation, sevoflurane concentration will be adjusted to maintain the end-tidal sevoflurane around 1-2% (0.5-1 MAC)</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Desflurane</intervention_name>
    <description>Desflurane is the volatile agent with low blood: gas partition coefficient (0.42), its uptake and elimination from the body of a patient are rapid, which results in a fast onset of anesthesia and a fast recovery from anesthesia. This property provides desflurane as an ideal agent for the ambulatory anesthesia. However, its pungent odor is concerned to irritate the upper airway and may cause significant respiratory complications.</description>
    <arm_group_label>Desflurane</arm_group_label>
    <other_name>Des</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Sevoflurane</intervention_name>
    <description>Sevoflurane has a blood: gas partition coefficient of 0.65, which is slightly greater than desflurane. The major advantage over desflurane is the better scented. It is considered to be less airway irritation in LMA anesthesia with smooth induction and recovery.</description>
    <arm_group_label>Sevoflurane</arm_group_label>
    <other_name>Sev</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion criteria:&#xD;
&#xD;
          -  Patients with American Society of Anesthesiologists physical status classification of&#xD;
             I-III&#xD;
&#xD;
          -  Elective surgery&#xD;
&#xD;
          -  Surgery with expected duration of operation of less than 2 hours&#xD;
&#xD;
          -  Surgery that anesthesiologist plans to use laryngeal mask airway during anesthesia&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Patients with gastroesophageal reflux disease&#xD;
&#xD;
          -  Patients with hiatal hernia&#xD;
&#xD;
          -  Patients with history of upper respiratory tract infection within 1 month before&#xD;
             surgery&#xD;
&#xD;
          -  Heavy smoker (&gt; 20 cigarettes per day)&#xD;
&#xD;
          -  Obese patients with body mass index &gt; 30kg/m2&#xD;
&#xD;
          -  Pregnant patients&#xD;
&#xD;
          -  Unable to provide a written informed consent patients&#xD;
&#xD;
          -  Surgery requiring non-depolarizing muscle relaxants&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>75 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Pathomporn Pin-on, M.D.</last_name>
    <role>Principal Investigator</role>
    <affiliation>Maharaj Nakorn Chiang Mai Hospital</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Pathomporn Pin-on, M.D.</last_name>
    <phone>66-86-897-0009</phone>
    <email>pinon.pathomporn@gmail.com</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Prangmalee Leurcharusmee, M.D.</last_name>
    <phone>66-89-759-2647</phone>
    <email>prangmalee.l@cmu.ac.th</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>Chiang Mai University</name>
      <address>
        <city>Chiang Mai</city>
        <zip>50200</zip>
        <country>Thailand</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Yodying Punjasawadwong, M.D.</last_name>
      <phone>66-81-992-8082</phone>
      <email>ypunjasa@gmail.com</email>
    </contact>
    <investigator>
      <last_name>Pathomporn Pin-on, M.D.</last_name>
      <role>Principal Investigator</role>
    </investigator>
    <investigator>
      <last_name>Prangmalee Leurcharusmee, M.D.</last_name>
      <role>Sub-Investigator</role>
    </investigator>
  </location>
  <location>
    <facility>
      <name>Chiang Mai University</name>
      <address>
        <city>Chiang Mai</city>
        <zip>50200</zip>
        <country>Thailand</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Yodying Punjasawadwong, M.D.</last_name>
      <phone>66-81-992-8082</phone>
      <email>ypunjasa@gmail.com</email>
    </contact>
    <investigator>
      <last_name>Pathomporm Pin-on, M.D.</last_name>
      <role>Principal Investigator</role>
    </investigator>
    <investigator>
      <last_name>Prangmalee Leurcharusmee, M.D.</last_name>
      <role>Sub-Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>Thailand</country>
  </location_countries>
  <reference>
    <citation>de Oliveira GS Jr, Girao W, Fitzgerald PC, McCarthy RJ. The effect of sevoflurane versus desflurane on the incidence of upper respiratory morbidity in patients undergoing general anesthesia with a Laryngeal Mask Airway: a meta-analysis of randomized controlled trials. J Clin Anesth. 2013 Sep;25(6):452-8. doi: 10.1016/j.jclinane.2013.03.012. Epub 2013 Aug 17.</citation>
    <PMID>23965188</PMID>
  </reference>
  <reference>
    <citation>De Oliveira GS Jr, Fitzgerald PC, Ahmad S, Marcus RJ, McCarthy RJ. Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial. J Clin Anesth. 2013 Dec;25(8):651-8. doi: 10.1016/j.jclinane.2013.07.006. Epub 2013 Oct 4.</citation>
    <PMID>24095885</PMID>
  </reference>
  <reference>
    <citation>Goodwin N, Strong PJ, Sudhir G, Wilkes AR, Hall JE. Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events. Anaesthesia. 2005 Oct;60(10):955-9. doi: 10.1111/j.1365-2044.2005.04279.x.</citation>
    <PMID>16179038</PMID>
  </reference>
  <reference>
    <citation>White PF, Eshima RW, Maurer A, King T, Lin BK, Heavner JE, Bogetz MS, Kaye AD. A comparison of airway responses during desflurane and sevoflurane administration via a laryngeal mask airway for maintenance of anesthesia. Anesth Analg. 2003 Mar;96(3):701-705. doi: 10.1213/01.ANE.0000048978.40522.AB.</citation>
    <PMID>12598249</PMID>
  </reference>
  <reference>
    <citation>McKay RE, Bostrom A, Balea MC, McKay WR. Airway responses during desflurane versus sevoflurane administration via a laryngeal mask airway in smokers. Anesth Analg. 2006 Nov;103(5):1147-54. doi: 10.1213/01.ane.0000237293.39466.65.</citation>
    <PMID>17056947</PMID>
  </reference>
  <reference>
    <citation>Mckay RE, Large MJC, Balea MC, Mckay WR. Airway reflexes return more rapidly after desflurane anesthesia than after sevoflurane anesthesia. Anesth Analg. 2005 Mar;100(3):697-700. doi: 10.1213/01.ANE.0000146514.65070.AE.</citation>
    <PMID>15728054</PMID>
  </reference>
  <reference>
    <citation>White PF, Tang J, Wender RH, Yumul R, Stokes OJ, Sloninsky A, Naruse R, Kariger R, Norel E, Mandel S, Webb T, Zaentz A. Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing. Anesth Analg. 2009 Aug;109(2):387-93. doi: 10.1213/ane.0b013e3181adc21a.</citation>
    <PMID>19608808</PMID>
  </reference>
  <reference>
    <citation>Mahmoud NA, Rose DJ, Laurence AS. Desflurane or sevoflurane for gynaecological day-case anaesthesia with spontaneous respiration? Anaesthesia. 2001 Feb;56(2):171-4. doi: 10.1046/j.1365-2044.2001.01528.x.</citation>
    <PMID>11167479</PMID>
  </reference>
  <verification_date>December 2018</verification_date>
  <study_first_submitted>July 24, 2016</study_first_submitted>
  <study_first_submitted_qc>December 26, 2016</study_first_submitted_qc>
  <study_first_posted type="Estimate">December 30, 2016</study_first_posted>
  <last_update_submitted>December 26, 2018</last_update_submitted>
  <last_update_submitted_qc>December 26, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">December 28, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Chiang Mai University</investigator_affiliation>
    <investigator_full_name>Pathomporn Pin on, M.D.</investigator_full_name>
    <investigator_title>Associate Professor</investigator_title>
  </responsible_party>
  <keyword>Desflurane</keyword>
  <keyword>Sevoflurane</keyword>
  <keyword>Respiratory Complications</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Respiratory System Abnormalities</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Sevoflurane</mesh_term>
    <mesh_term>Desflurane</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
    <ipd_description>The investigators don't have a plan to share data. The investigators plan to make an individual participant data available only in site.</ipd_description>
  </patient_data>
  <pending_results>
    <submitted>July 12, 2019</submitted>
    <returned>August 16, 2019</returned>
  </pending_results>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT03006250
org study id: 15072016
nct id: NCT03006250
lead sponsor: 
has dmc: Yes
The effects of desflurane versus sevoflurane in adult patients undergoing LMA anesthesia on
      respiratory events during a less than 2-hour elective surgery.
Laryngeal Mask Airway (LMA) anesthesia is generally performed for ambulatory surgery to avoid
      the use of neuromuscular blocking agents and to facilitate rapid emergence from anesthesia.
      Inhaled anesthetics are simply and popularly used during maintenance of anesthesia. The two
      most recent volatile anesthetic agents, desflurane and sevoflurane, are the two most commonly
      used in clinical practice for an ambulatory setting.

      Desflurane is the volatile agent with low blood: gas partition coefficient (0.42).
      Desflurane's uptake and elimination from the body of a patient are rapid, which results in a
      fast onset of anesthesia and a fast recovery from anesthesia. This property provides
      desflurane as an ideal agent for the ambulatory anesthesia. However, its pungent odor is
      concerned to irritate the upper airway and may cause significant respiratory complications.
      Sevoflurane has a blood: gas partition coefficient of 0.65, which is slightly greater than
      desflurane. The major advantage over desflurane is the better scent. It is considered to be
      less airway irritation in LMA anesthesia with smooth induction and recovery.

      The limitation of desflurane on its odor leads to a controversy if desflurane is similar to
      or worse than sevoflurane for LMA anesthesia. This is non-inferiority study designed to
      compare the occurrence of respiratory complications between desflurane and sevoflurane during
      LMA anesthesia.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Diagnostic
masking: Triple (Participant, Investigator, Outcomes Assessor)
measure: Occurrence of respiratory complications
time frame: From the beginning of operation until 30 minutes after the operation
description: Respiratory complications are coughing, breath holding, laryngospasm, bronchospasm, and desaturation
measure: Time of eye opening
time frame: Within 30 minutes after the end of operation
description: It is the time from discontinuation of anesthetic to the eye opening on verbal command.
measure: Time to follow motor command
time frame: Within 30 minutes after the end of operation
description: It is the time from discontinuation of anesthetic to hand squeezing.
measure: Time of LMA removal
time frame: Within 30 minutes after the end of operation
description: It is the time from discontinuation of anesthetic to removal of LMA.
measure: Frequency of postoperative nausea and vomiting (PONV)
time frame: Within 2 hours after operation
description: It is a number of patients with PONV in the early post-anesthetic period.
measure: Changes of blood pressure during anesthesia
time frame: Every 15 minutes, from the beginning of operation until 30 minutes after the operation
description: Non-invasive blood pressure will be recorded at the beginning of anesthesia, every 15 minutes during anesthetic maintenance, and at the time of LMA removal.
measure: Changes of heart rate during anesthesia
time frame: Every 15 minutes, from the beginning of operation until 30 minutes after the operation
description: Heart rate will be recorded at the beginning of anesthesia, every 15 minutes during anesthetic maintenance, and at the time of LMA removal.
measure: Time to achieve a satisfied Modified Aldrete score
time frame: Within 2 hours after operation
description: It is the time that the patient is ready to be discharged from post-anesthetic care unit.
measure: Number of Patients with high satisfaction to anesthesia
time frame: At 12-24 hour after surgery
description: The satisfaction is graded using a 5-point rating scale.
arm group label: Desflurane
arm group type: Experimental
description: Desflurane group: The rule of 24 will be applied, which means that the fresh gas flow (l/ min) multiplied by volume percent of desflurane must not exceed 24. Therefore, once the patients return of spontaneous ventilation, an anesthesiologist turns on oxygen 1 l/ min, nitrous oxide 1 l/ min, and desflurane 12 vol% for 1-2 minutes. When the end-tidal desflurane reaches 3-3.5% (approximately 0.5 MAC), the anesthesiologist will decrease oxygen and nitrous oxide to each 0.5 l/ min and desflurane to 6 vol% (1 MAC). Desflurane concentration will be adjusted to maintain the end-tidal desflurane around 3-6% (0.5-1 MAC).
arm group label: Sevoflurane
arm group type: Active Comparator
description: Sevoflurane group: The oxygen and nitrous oxide each 1 l/min will be turned on with sevoflurane 4 vol% for 1-2 minutes or until the end-tidal sevoflurane reach 1-1.2% (approximately 0.5 MAC). After that, the flow of oxygen and nitrous oxide is reduced to each 0.5 l/ min and concentration dial of sevoflurane is set to 2 vol% (1 MAC). During the operation, sevoflurane concentration will be adjusted to maintain the end-tidal sevoflurane around 1-2% (0.5-1 MAC)
intervention type: Drug
intervention name: Desflurane
description: Desflurane is the volatile agent with low blood: gas partition coefficient (0.42), its uptake and elimination from the body of a patient are rapid, which results in a fast onset of anesthesia and a fast recovery from anesthesia. This property provides desflurane as an ideal agent for the ambulatory anesthesia. However, its pungent odor is concerned to irritate the upper airway and may cause significant respiratory complications.
arm group label: Desflurane
other name: Des
intervention type: Drug
intervention name: Sevoflurane
description: Sevoflurane has a blood: gas partition coefficient of 0.65, which is slightly greater than desflurane. The major advantage over desflurane is the better scented. It is considered to be less airway irritation in LMA anesthesia with smooth induction and recovery.
arm group label: Sevoflurane
other name: Sev
criteria: 
gender: All
minimum age: 18 Years
maximum age: 75 Years
healthy volunteers: No
last name: Pathomporn Pin-on, M.D.
role: Principal Investigator
affiliation: Maharaj Nakorn Chiang Mai Hospital
last name: Pathomporn Pin-on, M.D.
phone: 66-86-897-0009
email: pinon.pathomporn@gmail.com
last name: Prangmalee Leurcharusmee, M.D.
phone: 66-89-759-2647
email: prangmalee.l@cmu.ac.th
facility: 
status: Recruiting
contact: 
investigator: 
investigator: 
facility: 
status: Recruiting
contact: 
investigator: 
investigator: 
country: Thailand
citation: de Oliveira GS Jr, Girao W, Fitzgerald PC, McCarthy RJ. The effect of sevoflurane versus desflurane on the incidence of upper respiratory morbidity in patients undergoing general anesthesia with a Laryngeal Mask Airway: a meta-analysis of randomized controlled trials. J Clin Anesth. 2013 Sep;25(6):452-8. doi: 10.1016/j.jclinane.2013.03.012. Epub 2013 Aug 17.
PMID: 23965188
citation: De Oliveira GS Jr, Fitzgerald PC, Ahmad S, Marcus RJ, McCarthy RJ. Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial. J Clin Anesth. 2013 Dec;25(8):651-8. doi: 10.1016/j.jclinane.2013.07.006. Epub 2013 Oct 4.
PMID: 24095885
citation: Goodwin N, Strong PJ, Sudhir G, Wilkes AR, Hall JE. Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events. Anaesthesia. 2005 Oct;60(10):955-9. doi: 10.1111/j.1365-2044.2005.04279.x.
PMID: 16179038
citation: White PF, Eshima RW, Maurer A, King T, Lin BK, Heavner JE, Bogetz MS, Kaye AD. A comparison of airway responses during desflurane and sevoflurane administration via a laryngeal mask airway for maintenance of anesthesia. Anesth Analg. 2003 Mar;96(3):701-705. doi: 10.1213/01.ANE.0000048978.40522.AB.
PMID: 12598249
citation: McKay RE, Bostrom A, Balea MC, McKay WR. Airway responses during desflurane versus sevoflurane administration via a laryngeal mask airway in smokers. Anesth Analg. 2006 Nov;103(5):1147-54. doi: 10.1213/01.ane.0000237293.39466.65.
PMID: 17056947
citation: Mckay RE, Large MJC, Balea MC, Mckay WR. Airway reflexes return more rapidly after desflurane anesthesia than after sevoflurane anesthesia. Anesth Analg. 2005 Mar;100(3):697-700. doi: 10.1213/01.ANE.0000146514.65070.AE.
PMID: 15728054
citation: White PF, Tang J, Wender RH, Yumul R, Stokes OJ, Sloninsky A, Naruse R, Kariger R, Norel E, Mandel S, Webb T, Zaentz A. Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing. Anesth Analg. 2009 Aug;109(2):387-93. doi: 10.1213/ane.0b013e3181adc21a.
PMID: 19608808
citation: Mahmoud NA, Rose DJ, Laurence AS. Desflurane or sevoflurane for gynaecological day-case anaesthesia with spontaneous respiration? Anaesthesia. 2001 Feb;56(2):171-4. doi: 10.1046/j.1365-2044.2001.01528.x.
PMID: 11167479
responsible party type: Principal Investigator
investigator affiliation: Chiang Mai University
investigator full name: Pathomporn Pin on, M.D.
investigator title: Associate Professor
mesh term: Respiratory System Abnormalities
mesh term: Sevoflurane
mesh term: Desflurane
sharing ipd: No
ipd description: The investigators don't have a plan to share data. The investigators plan to make an individual participant data available only in site.
submitted: July 12, 2019
returned: August 16, 2019