<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02198937</url>
  </required_header>
  <id_info>
    <org_study_id>KEK-ZH-NR. 2014-0078</org_study_id>
    <nct_id>NCT02198937</nct_id>
  </id_info>
  <brief_title>Investigation on the Effect of Smoking on the Expression of Pro- and Anti-thrombotic, Anti-oxidative, and Inflammatory Markers in Humans</brief_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Zurich</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>University of Zurich</source>
  <brief_summary>
    <textblock>
      Investigation on the effect of smoking on thrombus formation in humans. The expression of&#xD;
      pro- and anti-thrombotic, anti-oxidative, and inflammatory markers will be assessed in 25-50&#xD;
      year old healthy smokers and non-smokers. The investigators are interested in possible&#xD;
      differences between the two groups.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Terminated</overall_status>
  <why_stopped>
    Funding unclear&#xD;
  </why_stopped>
  <start_date>June 2014</start_date>
  <completion_date type="Actual">March 2016</completion_date>
  <primary_completion_date type="Actual">March 2016</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Control</observational_model>
    <time_perspective>Cross-Sectional</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Expression of pro- and anti-thrombotic, anti-oxidative, and inflammatory markers in blood</measure>
    <time_frame>Single time point, no follow-up (cross sectional)</time_frame>
  </primary_outcome>
  <number_of_groups>2</number_of_groups>
  <enrollment type="Actual">10</enrollment>
  <condition>Inflammation</condition>
  <condition>Thrombosis</condition>
  <condition>Smoking</condition>
  <arm_group>
    <arm_group_label>Smokers</arm_group_label>
    <description>Healthy smokers</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Non-Smokers</arm_group_label>
    <description>Healthy non-smokers</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Blood sample</intervention_name>
    <arm_group_label>Non-Smokers</arm_group_label>
    <arm_group_label>Smokers</arm_group_label>
  </intervention>
  <biospec_descr>
    <textblock>
      Blood sample&#xD;
    </textblock>
  </biospec_descr>
  <eligibility>
    <study_pop>
      <textblock>
        Smokers and non-smokers&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Smoker&#xD;
&#xD;
          -  Non-smokers&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Disease&#xD;
&#xD;
          -  Pregnancy&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>25 Years</minimum_age>
    <maximum_age>50 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>University Hospital</name>
      <address>
        <city>Zurich</city>
        <country>Switzerland</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Switzerland</country>
  </location_countries>
  <verification_date>October 2016</verification_date>
  <study_first_submitted>July 21, 2014</study_first_submitted>
  <study_first_submitted_qc>July 23, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">July 24, 2014</study_first_posted>
  <last_update_submitted>October 24, 2016</last_update_submitted>
  <last_update_submitted_qc>October 24, 2016</last_update_submitted_qc>
  <last_update_posted type="Estimate">October 25, 2016</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>University of Zurich</investigator_affiliation>
    <investigator_full_name>Simon Staempfli</investigator_full_name>
    <investigator_title>MD</investigator_title>
  </responsible_party>
  <keyword>smokers</keyword>
  <keyword>non-smokers</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Thrombosis</mesh_term>
    <mesh_term>Inflammation</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02198937
org study id: KEK-ZH-NR. 2014-0078
nct id: NCT02198937
lead sponsor: 
Investigation on the effect of smoking on thrombus formation in humans. The expression of
      pro- and anti-thrombotic, anti-oxidative, and inflammatory markers will be assessed in 25-50
      year old healthy smokers and non-smokers. The investigators are interested in possible
      differences between the two groups.
observational model: Case-Control
time perspective: Cross-Sectional
measure: Expression of pro- and anti-thrombotic, anti-oxidative, and inflammatory markers in blood
time frame: Single time point, no follow-up (cross sectional)
arm group label: Smokers
description: Healthy smokers
arm group label: Non-Smokers
description: Healthy non-smokers
intervention type: Other
intervention name: Blood sample
arm group label: Non-Smokers
arm group label: Smokers
Blood sample
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 25 Years
maximum age: 50 Years
healthy volunteers: Accepts Healthy Volunteers
facility: 
country: Switzerland
responsible party type: Principal Investigator
investigator affiliation: University of Zurich
investigator full name: Simon Staempfli
investigator title: MD
mesh term: Thrombosis
mesh term: Inflammation