<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02243384</url>
  </required_header>
  <id_info>
    <org_study_id>chenjian-01</org_study_id>
    <nct_id>NCT02243384</nct_id>
  </id_info>
  <brief_title>Laparoscopic Hepatectomy and Radiofrequency Ablation in the Treatment of Early Hepatocellular Carcinoma</brief_title>
  <official_title>A Randomized Controlled Trial of Laparoscopic Hepatectomy and Radiofrequency Ablation in the Treatment of Early Hepatocellular Carcinoma</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>ChenJian</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Southwest Hospital, China</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The purpose of this research is to compare short-term and long-term efficacy of laparoscopic&#xD;
      hepatectomy and radiofrequency ablation in the Treatment of early hepatocellular carcinoma,&#xD;
      and provide the evidence for the choice of surgical method from the pathology and cytology.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Background:The aim of this study was to compare the efficacy of laparoscopic hepatectomy(LH)&#xD;
      with radiofrequency ablation (RFA) in the treatment of early hepatocellular carcinoma (HCC).&#xD;
&#xD;
      Methods:A total of 110 patients with early HCC with nodular diameters of less than 3 cm and&#xD;
      up to three nodules were randomly divided into LH (n=55) and RFA groups (n=55). Outcomes were&#xD;
      carefully monitored and evaluated during the 3-year follow-up period.&#xD;
&#xD;
      Results:&#xD;
&#xD;
      operation time, intraoperative blood loss, rate of blood transfusion, complications and&#xD;
      mortality, postoperative liver function, resection margin, number of micrometastases&#xD;
      ,long-term curative effect and survival time were collected and analysed.&#xD;
&#xD;
      groups t-test ，univariate/multivariate analysis, logistic regression analysis, mixed linear&#xD;
      regression, Cox survival analysis ，Kaplan-Meier survival analysis，Log-rank survival curves&#xD;
      were used.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">September 1, 2014</start_date>
  <completion_date type="Actual">October 1, 2021</completion_date>
  <primary_completion_date type="Actual">January 1, 2021</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Investigator, Outcomes Assessor)</masking>
    <masking_description>Participants and researchers do not understand the test grouping, but the research designer arranges and controls all trials.</masking_description>
  </study_design_info>
  <primary_outcome>
    <measure>Survival rate</measure>
    <time_frame>5 years</time_frame>
    <description>follow-up after the surgery every 2 months, to understand relapse, death, statistics 1 year, 2-year and 3-year survival, disease-free survival, recurrence rate.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>postoperative complications</measure>
    <time_frame>Duration hospitalization(an expected average of 7 days)</time_frame>
    <description>hepatic failure,hemorrhage,biliary leakage,ascites,intra-abdominal infection,pleural effusion,pulmonary infection,cardiac insufficiency.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">150</enrollment>
  <condition>Hepatocellular Carcinoma</condition>
  <arm_group>
    <arm_group_label>Laparoscopic Hepatectomy</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Laparoscopic Hepatectomy</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Radiofrequency Ablation</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Radiofrequency Ablation</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Laparoscopic Hepatectomy</intervention_name>
    <description>A total of 110 patients with early HCC with nodular diameters of less than 3 cm and up to three nodules were randomly divided into LH (n=55) and RFA groups (n=55). Outcomes were carefully monitored and evaluated during the 3-year follow-up period</description>
    <arm_group_label>Laparoscopic Hepatectomy</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Radiofrequency Ablation</intervention_name>
    <description>A total of 110 patients with early HCC with nodular diameters of less than 3 cm and up to three nodules were randomly divided into LH (n=55) and RFA groups (n=55). Outcomes were carefully monitored and evaluated during the 3-year follow-up period</description>
    <arm_group_label>Radiofrequency Ablation</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Any gender,18 to 70 years old;&#xD;
&#xD;
          -  Preoperative diagnosis of primary liver clear;&#xD;
&#xD;
          -  No active hepatitis and decompensated cirrhosis;&#xD;
&#xD;
          -  Maximum diameter ≤3cm single nodules or three nodules in diameter and no more than&#xD;
             3cm,did not infringe the portal vein,hepatic vein and inferior vena cava&#xD;
             invasion,lymph node or extrahepatic turn;&#xD;
&#xD;
          -  No tumor rupture or bleeding;&#xD;
&#xD;
          -  Child-Pugh class A or B grade,ICG-R15 &lt;14%;&#xD;
&#xD;
          -  No coagulation disorders,platelet count &gt; 50 × 109 / L and prolonged prothrombin time&#xD;
             &lt; 5 seconds;&#xD;
&#xD;
          -  Not be including related surgery,radiofrequency ablation (RFA),TACE treatment,no&#xD;
             certainty anticancer chemotherapy treatment;supreme absolute contraindications&#xD;
             abdominal surgery;&#xD;
&#xD;
          -  Patients generally available,heart and lung function can tolerate surgery, abdominal&#xD;
             surgery supreme absolute contraindications;&#xD;
&#xD;
          -  Voluntarily participate in the study,informed consent.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Age &lt; 18 years or &gt; 70,pregnant and lactating women;&#xD;
&#xD;
          -  Primary liver cancer diagnosis is not clear&#xD;
&#xD;
          -  Liver function assessment:Child-PughC level,liver function reserve situation :ICGR-15&gt;&#xD;
             14%&#xD;
&#xD;
          -  Tumor rupture has occurred,or has the line before surgery,radiofrequency ablation&#xD;
             (RFA),TACE or chemotherapy cancer treatment;&#xD;
&#xD;
          -  Tips liver imaging with multiple ( &gt; 3 ) lesion,or tumor diameter&gt; 3 cm, clear portal&#xD;
             vein,hepatic vein,inferior vena cava tumor thrombus trunk;&#xD;
&#xD;
          -  Preoperative liver metastasis;&#xD;
&#xD;
          -  Preoperative evaluation of cardiopulmonary dysfunction patients who can not tolerate&#xD;
             surgery;&#xD;
&#xD;
          -  Intraoperative exploration has occurred disseminated tumor and / or lymph node&#xD;
             metastasis;&#xD;
&#xD;
          -  Exploratory surgery found that non-hepatic primary tumors,such as colorectal&#xD;
             metastases,hilar cell carcinoma;&#xD;
&#xD;
          -  Severe upper abdominal adhesions;&#xD;
&#xD;
          -  Postoperative pathological examination of the bile duct cell or mixed cell carcinoma&#xD;
             and pathologically confirmed positive margin;&#xD;
&#xD;
          -  Foreign,Hong Kong,Macao,Taiwan and other regions,estimated postoperative difficult to&#xD;
             track,followed up.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>70 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Jian Chen</last_name>
    <role>Study Chair</role>
    <affiliation>Institute of Hepatobiliary Surgery ,Southwest Hospital ,Third Military Medical University</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>JianChen</name>
      <address>
        <city>Chongqing</city>
        <state>Chongqing</state>
        <zip>400038</zip>
        <country>China</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
  <results_reference>
    <citation>Amarapurkar D, Han KH, Chan HL, Ueno Y; Asia-Pacific Working Party on Prevention of Hepatocellular Carcinoma. Application of surveillance programs for hepatocellular carcinoma in the Asia-Pacific Region. J Gastroenterol Hepatol. 2009 Jun;24(6):955-61. doi: 10.1111/j.1440-1746.2009.05805.x. Epub 2009 Mar 11.</citation>
    <PMID>19383082</PMID>
  </results_reference>
  <results_reference>
    <citation>Bruix J, Sherman M; American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update. Hepatology. 2011 Mar;53(3):1020-2. doi: 10.1002/hep.24199. No abstract available.</citation>
    <PMID>21374666</PMID>
  </results_reference>
  <results_reference>
    <citation>Jarnagin W, Chapman WC, Curley S, D'Angelica M, Rosen C, Dixon E, Nagorney D; American Hepato-Pancreato-Biliary Association; Society of Surgical Oncology; Society for Surgery of the Alimentary Tract. Surgical treatment of hepatocellular carcinoma: expert consensus statement. HPB (Oxford). 2010 Jun;12(5):302-10. doi: 10.1111/j.1477-2574.2010.00182.x.</citation>
    <PMID>20590903</PMID>
  </results_reference>
  <results_reference>
    <citation>Zimmerman MA, Ghobrial RM, Tong MJ, Hiatt JR, Cameron AM, Hong J, Busuttil RW. Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicators. Arch Surg. 2008 Feb;143(2):182-8; discussion 188. doi: 10.1001/archsurg.2007.39.</citation>
    <PMID>18283144</PMID>
  </results_reference>
  <results_reference>
    <citation>Reich H, McGlynn F, DeCaprio J, Budin R. Laparoscopic excision of benign liver lesions. Obstet Gynecol. 1991 Nov;78(5 Pt 2):956-8.</citation>
    <PMID>1833688</PMID>
  </results_reference>
  <results_reference>
    <citation>Kobayashi T. Long-term Survival Analysis of Pure Laparoscopic Versus Open Hepatectomy for Hepatocellular Carcinoma in Patients With Cirrhosis: A Single-center Experience. Ann Surg. 2015 Jul;262(1):e20. doi: 10.1097/SLA.0000000000000443. No abstract available.</citation>
    <PMID>24368662</PMID>
  </results_reference>
  <results_reference>
    <citation>Zhou YM, Shao WY, Zhao YF, Xu DH, Li B. Meta-analysis of laparoscopic versus open resection for hepatocellular carcinoma. Dig Dis Sci. 2011 Jul;56(7):1937-43. doi: 10.1007/s10620-011-1572-7. Epub 2011 Jan 23.</citation>
    <PMID>21259071</PMID>
  </results_reference>
  <results_reference>
    <citation>Nguyen KT, Marsh JW, Tsung A, Steel JJ, Gamblin TC, Geller DA. Comparative benefits of laparoscopic vs open hepatic resection: a critical appraisal. Arch Surg. 2011 Mar;146(3):348-56. doi: 10.1001/archsurg.2010.248. Epub 2010 Nov 15.</citation>
    <PMID>21079109</PMID>
  </results_reference>
  <results_reference>
    <citation>Cherqui D, Husson E, Hammoud R, Malassagne B, Stephan F, Bensaid S, Rotman N, Fagniez PL. Laparoscopic liver resections: a feasibility study in 30 patients. Ann Surg. 2000 Dec;232(6):753-62. doi: 10.1097/00000658-200012000-00004.</citation>
    <PMID>11088070</PMID>
  </results_reference>
  <results_reference>
    <citation>Otsuka Y, Tsuchiya M, Maeda T, Katagiri T, Isii J, Tamura A, Yamazaki K, Kubota Y, Suzuki T, Suzuki T, Kagami S, Kaneko H. Laparoscopic hepatectomy for liver tumors: proposals for standardization. J Hepatobiliary Pancreat Surg. 2009;16(6):720-5. doi: 10.1007/s00534-009-0139-x. Epub 2009 Aug 4.</citation>
    <PMID>19652902</PMID>
  </results_reference>
  <results_reference>
    <citation>Ishizawa T, Gumbs AA, Kokudo N, Gayet B. Laparoscopic segmentectomy of the liver: from segment I to VIII. Ann Surg. 2012 Dec;256(6):959-64. doi: 10.1097/SLA.0b013e31825ffed3.</citation>
    <PMID>22968066</PMID>
  </results_reference>
  <results_reference>
    <citation>Dagher I, Belli G, Fantini C, Laurent A, Tayar C, Lainas P, Tranchart H, Franco D, Cherqui D. Laparoscopic hepatectomy for hepatocellular carcinoma: a European experience. J Am Coll Surg. 2010 Jul;211(1):16-23. doi: 10.1016/j.jamcollsurg.2010.03.012. Epub 2010 May 26.</citation>
    <PMID>20610244</PMID>
  </results_reference>
  <results_reference>
    <citation>Livraghi T. Radiofrequency ablation of hepatocellular carcinoma. Surg Oncol Clin N Am. 2011 Apr;20(2):281-99, viii. doi: 10.1016/j.soc.2010.11.010.</citation>
    <PMID>21377584</PMID>
  </results_reference>
  <results_reference>
    <citation>Lau WY, Lai EC. The current role of radiofrequency ablation in the management of hepatocellular carcinoma: a systematic review. Ann Surg. 2009 Jan;249(1):20-5. doi: 10.1097/SLA.0b013e31818eec29.</citation>
    <PMID>19106671</PMID>
  </results_reference>
  <results_reference>
    <citation>Mulier S, Ni Y, Jamart J, Ruers T, Marchal G, Michel L. Local recurrence after hepatic radiofrequency coagulation: multivariate meta-analysis and review of contributing factors. Ann Surg. 2005 Aug;242(2):158-71. doi: 10.1097/01.sla.0000171032.99149.fe.</citation>
    <PMID>16041205</PMID>
  </results_reference>
  <results_reference>
    <citation>Feng K, Yan J, Li X, Xia F, Ma K, Wang S, Bie P, Dong J. A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma. J Hepatol. 2012 Oct;57(4):794-802. doi: 10.1016/j.jhep.2012.05.007. Epub 2012 May 23.</citation>
    <PMID>22634125</PMID>
  </results_reference>
  <results_reference>
    <citation>Buell JF, Cherqui D, Geller DA, O'Rourke N, Iannitti D, Dagher I, Koffron AJ, Thomas M, Gayet B, Han HS, Wakabayashi G, Belli G, Kaneko H, Ker CG, Scatton O, Laurent A, Abdalla EK, Chaudhury P, Dutson E, Gamblin C, D'Angelica M, Nagorney D, Testa G, Labow D, Manas D, Poon RT, Nelson H, Martin R, Clary B, Pinson WC, Martinie J, Vauthey JN, Goldstein R, Roayaie S, Barlet D, Espat J, Abecassis M, Rees M, Fong Y, McMasters KM, Broelsch C, Busuttil R, Belghiti J, Strasberg S, Chari RS; World Consensus Conference on Laparoscopic Surgery. The international position on laparoscopic liver surgery: The Louisville Statement, 2008. Ann Surg. 2009 Nov;250(5):825-30. doi: 10.1097/sla.0b013e3181b3b2d8.</citation>
    <PMID>19916210</PMID>
  </results_reference>
  <results_reference>
    <citation>Yin Z, Fan X, Ye H, Yin D, Wang J. Short- and long-term outcomes after laparoscopic and open hepatectomy for hepatocellular carcinoma: a global systematic review and meta-analysis. Ann Surg Oncol. 2013 Apr;20(4):1203-15. doi: 10.1245/s10434-012-2705-8. Epub 2012 Oct 26.</citation>
    <PMID>23099728</PMID>
  </results_reference>
  <results_reference>
    <citation>Katz SC, Shia J, Liau KH, Gonen M, Ruo L, Jarnagin WR, Fong Y, D'Angelica MI, Blumgart LH, Dematteo RP. Operative blood loss independently predicts recurrence and survival after resection of hepatocellular carcinoma. Ann Surg. 2009 Apr;249(4):617-23. doi: 10.1097/SLA.0b013e31819ed22f.</citation>
    <PMID>19300227</PMID>
  </results_reference>
  <results_reference>
    <citation>Minami Y, Kudo M. Radiofrequency ablation of hepatocellular carcinoma: Current status. World J Radiol. 2010 Nov 28;2(11):417-24. doi: 10.4329/wjr.v2.i11.417.</citation>
    <PMID>21179308</PMID>
  </results_reference>
  <results_reference>
    <citation>Shi M, Guo RP, Lin XJ, Zhang YQ, Chen MS, Zhang CQ, Lau WY, Li JQ. Partial hepatectomy with wide versus narrow resection margin for solitary hepatocellular carcinoma: a prospective randomized trial. Ann Surg. 2007 Jan;245(1):36-43. doi: 10.1097/01.sla.0000231758.07868.71.</citation>
    <PMID>17197963</PMID>
  </results_reference>
  <results_reference>
    <citation>Curley SA. Radiofrequency ablation leads to excellent local tumor control and durable longterm survival in specific subsets of early stage HCC patients confirming to the Milan criteria. Ann Surg. 2010 Dec;252(6):913-4. doi: 10.1097/SLA.0b013e3182034862. No abstract available.</citation>
    <PMID>21107101</PMID>
  </results_reference>
  <results_reference>
    <citation>Huang J, Yan L, Cheng Z, Wu H, Du L, Wang J, Xu Y, Zeng Y. A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the Milan criteria. Ann Surg. 2010 Dec;252(6):903-12. doi: 10.1097/SLA.0b013e3181efc656.</citation>
    <PMID>21107100</PMID>
  </results_reference>
  <verification_date>May 2022</verification_date>
  <study_first_submitted>September 15, 2014</study_first_submitted>
  <study_first_submitted_qc>September 15, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 17, 2014</study_first_posted>
  <last_update_submitted>May 29, 2022</last_update_submitted>
  <last_update_submitted_qc>May 29, 2022</last_update_submitted_qc>
  <last_update_posted type="Actual">June 2, 2022</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>Southwest Hospital, China</investigator_affiliation>
    <investigator_full_name>ChenJian</investigator_full_name>
    <investigator_title>Associate Professor of Hepatobiliary Surgery Institute; Chief Physician; Administrator of laparoscopic department</investigator_title>
  </responsible_party>
  <keyword>Early Hepatocellular Carcinoma</keyword>
  <keyword>Laparoscopic Hepatectomy</keyword>
  <keyword>Radiofrequency Ablation</keyword>
  <keyword>Micrometastases</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Carcinoma</mesh_term>
    <mesh_term>Carcinoma, Hepatocellular</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02243384
org study id: chenjian-01
nct id: NCT02243384
lead sponsor: 
has dmc: Yes
The purpose of this research is to compare short-term and long-term efficacy of laparoscopic
      hepatectomy and radiofrequency ablation in the Treatment of early hepatocellular carcinoma,
      and provide the evidence for the choice of surgical method from the pathology and cytology.
Background:The aim of this study was to compare the efficacy of laparoscopic hepatectomy(LH)
      with radiofrequency ablation (RFA) in the treatment of early hepatocellular carcinoma (HCC).

      Methods:A total of 110 patients with early HCC with nodular diameters of less than 3 cm and
      up to three nodules were randomly divided into LH (n=55) and RFA groups (n=55). Outcomes were
      carefully monitored and evaluated during the 3-year follow-up period.

      Results:

      operation time, intraoperative blood loss, rate of blood transfusion, complications and
      mortality, postoperative liver function, resection margin, number of micrometastases
      ,long-term curative effect and survival time were collected and analysed.

      groups t-test ，univariate/multivariate analysis, logistic regression analysis, mixed linear
      regression, Cox survival analysis ，Kaplan-Meier survival analysis，Log-rank survival curves
      were used.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Double (Investigator, Outcomes Assessor)
masking description: Participants and researchers do not understand the test grouping, but the research designer arranges and controls all trials.
measure: Survival rate
time frame: 5 years
description: follow-up after the surgery every 2 months, to understand relapse, death, statistics 1 year, 2-year and 3-year survival, disease-free survival, recurrence rate.
measure: postoperative complications
time frame: Duration hospitalization(an expected average of 7 days)
description: hepatic failure,hemorrhage,biliary leakage,ascites,intra-abdominal infection,pleural effusion,pulmonary infection,cardiac insufficiency.
arm group label: Laparoscopic Hepatectomy
arm group type: Experimental
description: Laparoscopic Hepatectomy
arm group label: Radiofrequency Ablation
arm group type: Active Comparator
description: Radiofrequency Ablation
intervention type: Procedure
intervention name: Laparoscopic Hepatectomy
description: A total of 110 patients with early HCC with nodular diameters of less than 3 cm and up to three nodules were randomly divided into LH (n=55) and RFA groups (n=55). Outcomes were carefully monitored and evaluated during the 3-year follow-up period
arm group label: Laparoscopic Hepatectomy
intervention type: Procedure
intervention name: Radiofrequency Ablation
description: A total of 110 patients with early HCC with nodular diameters of less than 3 cm and up to three nodules were randomly divided into LH (n=55) and RFA groups (n=55). Outcomes were carefully monitored and evaluated during the 3-year follow-up period
arm group label: Radiofrequency Ablation
criteria: 
gender: All
minimum age: 18 Years
maximum age: 70 Years
healthy volunteers: No
last name: Jian Chen
role: Study Chair
affiliation: Institute of Hepatobiliary Surgery ,Southwest Hospital ,Third Military Medical University
facility: 
country: China
citation: Amarapurkar D, Han KH, Chan HL, Ueno Y; Asia-Pacific Working Party on Prevention of Hepatocellular Carcinoma. Application of surveillance programs for hepatocellular carcinoma in the Asia-Pacific Region. J Gastroenterol Hepatol. 2009 Jun;24(6):955-61. doi: 10.1111/j.1440-1746.2009.05805.x. Epub 2009 Mar 11.
PMID: 19383082
citation: Bruix J, Sherman M; American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update. Hepatology. 2011 Mar;53(3):1020-2. doi: 10.1002/hep.24199. No abstract available.
PMID: 21374666
citation: Jarnagin W, Chapman WC, Curley S, D'Angelica M, Rosen C, Dixon E, Nagorney D; American Hepato-Pancreato-Biliary Association; Society of Surgical Oncology; Society for Surgery of the Alimentary Tract. Surgical treatment of hepatocellular carcinoma: expert consensus statement. HPB (Oxford). 2010 Jun;12(5):302-10. doi: 10.1111/j.1477-2574.2010.00182.x.
PMID: 20590903
citation: Zimmerman MA, Ghobrial RM, Tong MJ, Hiatt JR, Cameron AM, Hong J, Busuttil RW. Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicators. Arch Surg. 2008 Feb;143(2):182-8; discussion 188. doi: 10.1001/archsurg.2007.39.
PMID: 18283144
citation: Reich H, McGlynn F, DeCaprio J, Budin R. Laparoscopic excision of benign liver lesions. Obstet Gynecol. 1991 Nov;78(5 Pt 2):956-8.
PMID: 1833688
citation: Kobayashi T. Long-term Survival Analysis of Pure Laparoscopic Versus Open Hepatectomy for Hepatocellular Carcinoma in Patients With Cirrhosis: A Single-center Experience. Ann Surg. 2015 Jul;262(1):e20. doi: 10.1097/SLA.0000000000000443. No abstract available.
PMID: 24368662
citation: Zhou YM, Shao WY, Zhao YF, Xu DH, Li B. Meta-analysis of laparoscopic versus open resection for hepatocellular carcinoma. Dig Dis Sci. 2011 Jul;56(7):1937-43. doi: 10.1007/s10620-011-1572-7. Epub 2011 Jan 23.
PMID: 21259071
citation: Nguyen KT, Marsh JW, Tsung A, Steel JJ, Gamblin TC, Geller DA. Comparative benefits of laparoscopic vs open hepatic resection: a critical appraisal. Arch Surg. 2011 Mar;146(3):348-56. doi: 10.1001/archsurg.2010.248. Epub 2010 Nov 15.
PMID: 21079109
citation: Cherqui D, Husson E, Hammoud R, Malassagne B, Stephan F, Bensaid S, Rotman N, Fagniez PL. Laparoscopic liver resections: a feasibility study in 30 patients. Ann Surg. 2000 Dec;232(6):753-62. doi: 10.1097/00000658-200012000-00004.
PMID: 11088070
citation: Otsuka Y, Tsuchiya M, Maeda T, Katagiri T, Isii J, Tamura A, Yamazaki K, Kubota Y, Suzuki T, Suzuki T, Kagami S, Kaneko H. Laparoscopic hepatectomy for liver tumors: proposals for standardization. J Hepatobiliary Pancreat Surg. 2009;16(6):720-5. doi: 10.1007/s00534-009-0139-x. Epub 2009 Aug 4.
PMID: 19652902
citation: Ishizawa T, Gumbs AA, Kokudo N, Gayet B. Laparoscopic segmentectomy of the liver: from segment I to VIII. Ann Surg. 2012 Dec;256(6):959-64. doi: 10.1097/SLA.0b013e31825ffed3.
PMID: 22968066
citation: Dagher I, Belli G, Fantini C, Laurent A, Tayar C, Lainas P, Tranchart H, Franco D, Cherqui D. Laparoscopic hepatectomy for hepatocellular carcinoma: a European experience. J Am Coll Surg. 2010 Jul;211(1):16-23. doi: 10.1016/j.jamcollsurg.2010.03.012. Epub 2010 May 26.
PMID: 20610244
citation: Livraghi T. Radiofrequency ablation of hepatocellular carcinoma. Surg Oncol Clin N Am. 2011 Apr;20(2):281-99, viii. doi: 10.1016/j.soc.2010.11.010.
PMID: 21377584
citation: Lau WY, Lai EC. The current role of radiofrequency ablation in the management of hepatocellular carcinoma: a systematic review. Ann Surg. 2009 Jan;249(1):20-5. doi: 10.1097/SLA.0b013e31818eec29.
PMID: 19106671
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responsible party type: Sponsor-Investigator
investigator affiliation: Southwest Hospital, China
investigator full name: ChenJian
investigator title: Associate Professor of Hepatobiliary Surgery Institute; Chief Physician; Administrator of laparoscopic department
mesh term: Carcinoma
mesh term: Carcinoma, Hepatocellular