<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02217098</url>
  </required_header>
  <id_info>
    <org_study_id>FOUSP6808912</org_study_id>
    <nct_id>NCT02217098</nct_id>
  </id_info>
  <brief_title>The Survival Rate of Glass Ionomer Cement, Glass Carbomer Cement and Compomer in Occlusal and Proximal ART Restorations</brief_title>
  <acronym>ARTUSP</acronym>
  <official_title>The Survival Rate of Glass Ionomer Cement, Glass Carbomer Cement and Compomer in Occlusal and Proximal ART Restorations</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Daniela Prócida Raggio</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Academic Centre for Dentistry in Amsterdam</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Sao Paulo</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The null hypothesis of this study is that GCC, GIC and compomer have the same survival rate&#xD;
      when used for the treatment of occlusal and proximal caries in primary molars with ART under&#xD;
      field conditions.&#xD;
&#xD;
      This research will be done under field conditions in Barueri, a city in the state of São&#xD;
      Paulo, Brazil. A total of 600 patients will be selected. After 1, 6, 12, 18 and 24 months the&#xD;
      restorations and teeth will be evaluated by two independent evaluators. Only children whose&#xD;
      parent or representative who have signed an informed consent are included in this&#xD;
      research.The ART treatments will be done by two dental students. The operators will receive&#xD;
      the same ART-training. The children will be randomly assigned to one of the operators. The&#xD;
      restorative material to be used in each child will be assigned by another random list. It&#xD;
      will be performed descriptive analyses to describe the sample. Bivariate analyses will be&#xD;
      performed to test the hypothesis. The data will be analyzed with a chi-square test to compare&#xD;
      the survival rates of GIC and GCC. Some co-variables will be evaluated, such as: operator&#xD;
      effect, the influence of the cavity size on the survival rate, the position of the tooth, the&#xD;
      dentists preferred side, the child's dmft/DMFT, contamination and finally the preoperative&#xD;
      conditions. The effect of these variables on the survival rate will be evaluated using a&#xD;
      regression analysis.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The null hypothesis of this study is that GCC, GIC and compomer have the same survival rate&#xD;
      when used for the treatment of occlusal and proximal caries in primary molars with ART under&#xD;
      field conditions.&#xD;
&#xD;
      This research will be done under field conditions in Barueri, a city in the state of São&#xD;
      Paulo, Brazil. A total of 600 patients will be selected, 300 patients with one occlusal carie&#xD;
      lesion and 300 different patients with occlusal proximal cavities. After 1, 6, 12, 18 and 24&#xD;
      months the restorations and teeth will be evaluated by two independent evaluators. Only&#xD;
      children whose parent or representative who have signed an informed consent are included in&#xD;
      this research. Only one restoration per child will be included in this study. If more carious&#xD;
      lesions are present, one of them will be randomly selected for this research. The remaining&#xD;
      carious lesions will be also be treated. The ART treatments will be done by two dental&#xD;
      students. The operators will receive the same ART-training.&#xD;
&#xD;
      The children will be randomly assigned to one of the operators. The restorative material to&#xD;
      be used in each child will be assigned by another random list.&#xD;
&#xD;
      The selected children can have or an occlusal (O) cavity or an occlusalproximal (OP) cavity.&#xD;
      So, the stratum of the study is OP and O. So, one randomization list will be performed for&#xD;
      occlusal cavities and another randomization list will be used for occlusal proximal cavities.&#xD;
&#xD;
      It will be performed descriptive analyses to describe the sample. Bivariate analyses will be&#xD;
      performed to test the hypothesis. The data will be analyzed with a chi-square test to compare&#xD;
      the survival rates of GIC and GCC. Some co-variables will be evaluated, such as: operator&#xD;
      effect, the influence of the cavity size on the survival rate, the position of the tooth, the&#xD;
      dentists preferred side, the child's dmft/DMFT, contamination and finally the preoperative&#xD;
      conditions. The effect of these variables on the survival rate will be evaluated using a&#xD;
      regression analysis.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date>July 2014</start_date>
  <completion_date type="Actual">September 10, 2018</completion_date>
  <primary_completion_date type="Actual">February 2015</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Double (Participant, Investigator)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Survival rate (longevity) of ART restorations using differents materials</measure>
    <time_frame>6, 12, 24 and 36 months follow-up</time_frame>
    <description>The null hypothesis of this study is that GCC, GIC and compomer have the same survival rate when used for the treatment of occlusal and occlusoproximal caries in primary molars with ART under field conditions.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Association between survival and gender</measure>
    <time_frame>6, 12, 24 and 36 months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Association between survival and DMFT (caries experience)</measure>
    <time_frame>6, 12, 24 and 36 months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Association between survival and occlusal contact after restoration</measure>
    <time_frame>6, 12, 24 and 36 months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Association between sucess and ICDAS of the adjacent tooth (if there is a dentin cavited lesion or not)</measure>
    <time_frame>6, 12, 24 and 36 months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Cost-effectiveness of the 3 materials and their association with survival rate</measure>
    <time_frame>6, 12, 24 and 36 months follow-up</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Comparition between Success of the restoration and longevity of the teeth (with or without pulp damage and exfoliation in the normal time)</measure>
    <time_frame>6, 12, 24 and 36 months follow-up</time_frame>
  </secondary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Actual">530</enrollment>
  <condition>Caries Involving Multiple Surfaces of Tooth</condition>
  <condition>Dental Caries on Chewing Surface of Tooth</condition>
  <condition>Dental Caries Extending Into Dentine</condition>
  <arm_group>
    <arm_group_label>GIC Restorations</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Restorations using Glass Ionomer Cement</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Compomer Restorations</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Restorations using Compomer</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Carbomer Restorations</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Restorations using Glass Carbomer</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>GIC Restorations</intervention_name>
    <description>Restorations using Glass Ionomer Cement</description>
    <arm_group_label>GIC Restorations</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Carbomer Restorations</intervention_name>
    <description>Restorations using Glass Carbomer</description>
    <arm_group_label>Carbomer Restorations</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Compomer Restorations</intervention_name>
    <description>Restorations using Compomer</description>
    <arm_group_label>Compomer Restorations</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
        Inclusion criteria for the patient:&#xD;
&#xD;
          -  Healthy children, age: 4-8 years&#xD;
&#xD;
          -  At least one occlusal or proximal carious lesion in primary molar involving dentin&#xD;
&#xD;
          -  Cooperative behavior&#xD;
&#xD;
          -  Presence of antagonist of the tooth&#xD;
&#xD;
        Inclusion criteria for the tooth:&#xD;
&#xD;
          -  Carious lesion involving dentin with dimensions bucco-lingual and mesio-distal not&#xD;
             greater than 2.5mm, occluso-cervical not greater than 2.0mm&#xD;
&#xD;
          -  Absence of tooth mobility and abscess or fistula near to the selected tooth&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Only children whose parent or representative who have signed an informed consent are&#xD;
             included in this research. Only one restoration per child will be included in this&#xD;
             study. If more carious lesions are present, one of them will be randomly selected for&#xD;
             this research.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>4 Years</minimum_age>
    <maximum_age>8 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Daniela P Raggio, Professor</last_name>
    <role>Principal Investigator</role>
    <affiliation>Universidade de Sao Paulo - Faculdade de Odontologia</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Isabel O Costa, PhD</last_name>
    <role>Study Director</role>
    <affiliation>University of São Paulo</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>School of Dentistry - Sao Paulo University</name>
      <address>
        <city>Sao Paulo</city>
        <zip>05508-000</zip>
        <country>Brazil</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Brazil</country>
  </location_countries>
  <reference>
    <citation>Bonifacio CC, Hesse D, Raggio DP, Bonecker M, van Loveren C, van Amerongen WE. The effect of GIC-brand on the survival rate of proximal-ART restorations. Int J Paediatr Dent. 2013 Jul;23(4):251-8. doi: 10.1111/j.1365-263X.2012.01259.x. Epub 2012 Aug 14.</citation>
    <PMID>22891625</PMID>
  </reference>
  <reference>
    <citation>de Amorim RG, Leal SC, Frencken JE. Survival of atraumatic restorative treatment (ART) sealants and restorations: a meta-analysis. Clin Oral Investig. 2012 Apr;16(2):429-41. doi: 10.1007/s00784-011-0513-3. Epub 2011 Jan 28.</citation>
    <PMID>21274581</PMID>
  </reference>
  <reference>
    <citation>Banerjee A, Kidd EA, Watson TF. In vitro evaluation of five alternative methods of carious dentine excavation. Caries Res. 2000 Mar-Apr;34(2):144-50. doi: 10.1159/000016582.</citation>
    <PMID>10773632</PMID>
  </reference>
  <reference>
    <citation>van Bochove JA, van Amerongen WE. The influence of restorative treatment approaches and the use of local analgesia, on the children's discomfort. Eur Arch Paediatr Dent. 2006 Mar;7(1):11-6. doi: 10.1007/BF03320809.</citation>
    <PMID>17140522</PMID>
  </reference>
  <reference>
    <citation>Carvalho TS, van Amerongen WE, de Gee A, Bonecker M, Sampaio FC. Shear bond strengths of three glass ionomer cements to enamel and dentine. Med Oral Patol Oral Cir Bucal. 2011 May 1;16(3):e406-10. doi: 10.4317/medoral.16.e406.</citation>
    <PMID>20526266</PMID>
  </reference>
  <reference>
    <citation>Cehreli SB, Tirali RE, Yalcinkaya Z, Cehreli ZC. Microleakage of newly developed glass carbomer cement in primary teeth. Eur J Dent. 2013 Jan;7(1):15-21.</citation>
    <PMID>23408469</PMID>
  </reference>
  <reference>
    <citation>Chen X, Du M, Fan M, Mulder J, Huysmans MC, Frencken JE. Effectiveness of two new types of sealants: retention after 2 years. Clin Oral Investig. 2012 Oct;16(5):1443-50. doi: 10.1007/s00784-011-0633-9. Epub 2011 Nov 29.</citation>
    <PMID>22124610</PMID>
  </reference>
  <reference>
    <citation>van Duinen RN, Kleverlaan CJ, de Gee AJ, Werner A, Feilzer AJ. Early and long-term wear of 'fast-set' conventional glass-ionomer cements. Dent Mater. 2005 Aug;21(8):716-20. doi: 10.1016/j.dental.2004.09.007.</citation>
    <PMID>16026667</PMID>
  </reference>
  <reference>
    <citation>Ersin NK, Candan U, Aykut A, Oncag O, Eronat C, Kose T. A clinical evaluation of resin-based composite and glass ionomer cement restorations placed in primary teeth using the ART approach: results at 24 months. J Am Dent Assoc. 2006 Nov;137(11):1529-36. doi: 10.14219/jada.archive.2006.0087.</citation>
    <PMID>17082278</PMID>
  </reference>
  <reference>
    <citation>Frencken JE, Pilot T, Songpaisan Y, Phantumvanit P. Atraumatic restorative treatment (ART): rationale, technique, and development. J Public Health Dent. 1996;56(3 Spec No):135-40; discussion 161-3. doi: 10.1111/j.1752-7325.1996.tb02423.x.</citation>
    <PMID>8915958</PMID>
  </reference>
  <reference>
    <citation>Kuhnisch J, Mansmann U, Heinrich-Weltzien R, Hickel R. Longevity of materials for pit and fissure sealing--results from a meta-analysis. Dent Mater. 2012 Mar;28(3):298-303. doi: 10.1016/j.dental.2011.11.002. Epub 2011 Dec 3.</citation>
    <PMID>22137936</PMID>
  </reference>
  <reference>
    <citation>Mickenautsch S, Mount G, Yengopal V. Therapeutic effect of glass-ionomers: an overview of evidence. Aust Dent J. 2011 Mar;56(1):10-5; quiz 103. doi: 10.1111/j.1834-7819.2010.01304.x.</citation>
    <PMID>21332735</PMID>
  </reference>
  <reference>
    <citation>Raggio DP, Hesse D, Lenzi TL, Guglielmi CA, Braga MM. Is Atraumatic restorative treatment an option for restoring occlusoproximal caries lesions in primary teeth? A systematic review and meta-analysis. Int J Paediatr Dent. 2013 Nov;23(6):435-43. doi: 10.1111/ipd.12013. Epub 2012 Nov 28.</citation>
    <PMID>23190278</PMID>
  </reference>
  <verification_date>November 2018</verification_date>
  <study_first_submitted>May 21, 2014</study_first_submitted>
  <study_first_submitted_qc>August 12, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">August 15, 2014</study_first_posted>
  <last_update_submitted>November 19, 2018</last_update_submitted>
  <last_update_submitted_qc>November 19, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">November 21, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>University of Sao Paulo</investigator_affiliation>
    <investigator_full_name>Daniela Prócida Raggio</investigator_full_name>
    <investigator_title>Associated Professor of Paediatric Dentistry</investigator_title>
  </responsible_party>
  <keyword>ART</keyword>
  <keyword>Occlusal</keyword>
  <keyword>Occlusoproximal</keyword>
  <keyword>Primary teeth</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Dental Caries</mesh_term>
  </condition_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02217098
org study id: FOUSP6808912
nct id: NCT02217098
lead sponsor: 
collaborator: 
has dmc: No
The null hypothesis of this study is that GCC, GIC and compomer have the same survival rate
      when used for the treatment of occlusal and proximal caries in primary molars with ART under
      field conditions.

      This research will be done under field conditions in Barueri, a city in the state of São
      Paulo, Brazil. A total of 600 patients will be selected. After 1, 6, 12, 18 and 24 months the
      restorations and teeth will be evaluated by two independent evaluators. Only children whose
      parent or representative who have signed an informed consent are included in this
      research.The ART treatments will be done by two dental students. The operators will receive
      the same ART-training. The children will be randomly assigned to one of the operators. The
      restorative material to be used in each child will be assigned by another random list. It
      will be performed descriptive analyses to describe the sample. Bivariate analyses will be
      performed to test the hypothesis. The data will be analyzed with a chi-square test to compare
      the survival rates of GIC and GCC. Some co-variables will be evaluated, such as: operator
      effect, the influence of the cavity size on the survival rate, the position of the tooth, the
      dentists preferred side, the child's dmft/DMFT, contamination and finally the preoperative
      conditions. The effect of these variables on the survival rate will be evaluated using a
      regression analysis.
The null hypothesis of this study is that GCC, GIC and compomer have the same survival rate
      when used for the treatment of occlusal and proximal caries in primary molars with ART under
      field conditions.

      This research will be done under field conditions in Barueri, a city in the state of São
      Paulo, Brazil. A total of 600 patients will be selected, 300 patients with one occlusal carie
      lesion and 300 different patients with occlusal proximal cavities. After 1, 6, 12, 18 and 24
      months the restorations and teeth will be evaluated by two independent evaluators. Only
      children whose parent or representative who have signed an informed consent are included in
      this research. Only one restoration per child will be included in this study. If more carious
      lesions are present, one of them will be randomly selected for this research. The remaining
      carious lesions will be also be treated. The ART treatments will be done by two dental
      students. The operators will receive the same ART-training.

      The children will be randomly assigned to one of the operators. The restorative material to
      be used in each child will be assigned by another random list.

      The selected children can have or an occlusal (O) cavity or an occlusalproximal (OP) cavity.
      So, the stratum of the study is OP and O. So, one randomization list will be performed for
      occlusal cavities and another randomization list will be used for occlusal proximal cavities.

      It will be performed descriptive analyses to describe the sample. Bivariate analyses will be
      performed to test the hypothesis. The data will be analyzed with a chi-square test to compare
      the survival rates of GIC and GCC. Some co-variables will be evaluated, such as: operator
      effect, the influence of the cavity size on the survival rate, the position of the tooth, the
      dentists preferred side, the child's dmft/DMFT, contamination and finally the preoperative
      conditions. The effect of these variables on the survival rate will be evaluated using a
      regression analysis.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Double (Participant, Investigator)
measure: Survival rate (longevity) of ART restorations using differents materials
time frame: 6, 12, 24 and 36 months follow-up
description: The null hypothesis of this study is that GCC, GIC and compomer have the same survival rate when used for the treatment of occlusal and occlusoproximal caries in primary molars with ART under field conditions.
measure: Association between survival and gender
time frame: 6, 12, 24 and 36 months follow-up
measure: Association between survival and DMFT (caries experience)
time frame: 6, 12, 24 and 36 months follow-up
measure: Association between survival and occlusal contact after restoration
time frame: 6, 12, 24 and 36 months follow-up
measure: Association between sucess and ICDAS of the adjacent tooth (if there is a dentin cavited lesion or not)
time frame: 6, 12, 24 and 36 months follow-up
measure: Cost-effectiveness of the 3 materials and their association with survival rate
time frame: 6, 12, 24 and 36 months follow-up
measure: Comparition between Success of the restoration and longevity of the teeth (with or without pulp damage and exfoliation in the normal time)
time frame: 6, 12, 24 and 36 months follow-up
arm group label: GIC Restorations
arm group type: Active Comparator
description: Restorations using Glass Ionomer Cement
arm group label: Compomer Restorations
arm group type: Experimental
description: Restorations using Compomer
arm group label: Carbomer Restorations
arm group type: Experimental
description: Restorations using Glass Carbomer
intervention type: Procedure
intervention name: GIC Restorations
description: Restorations using Glass Ionomer Cement
arm group label: GIC Restorations
intervention type: Procedure
intervention name: Carbomer Restorations
description: Restorations using Glass Carbomer
arm group label: Carbomer Restorations
intervention type: Procedure
intervention name: Compomer Restorations
description: Restorations using Compomer
arm group label: Compomer Restorations
criteria: 
gender: All
minimum age: 4 Years
maximum age: 8 Years
healthy volunteers: No
last name: Daniela P Raggio, Professor
role: Principal Investigator
affiliation: Universidade de Sao Paulo - Faculdade de Odontologia
last name: Isabel O Costa, PhD
role: Study Director
affiliation: University of São Paulo
facility: 
country: Brazil
citation: Bonifacio CC, Hesse D, Raggio DP, Bonecker M, van Loveren C, van Amerongen WE. The effect of GIC-brand on the survival rate of proximal-ART restorations. Int J Paediatr Dent. 2013 Jul;23(4):251-8. doi: 10.1111/j.1365-263X.2012.01259.x. Epub 2012 Aug 14.
PMID: 22891625
citation: de Amorim RG, Leal SC, Frencken JE. Survival of atraumatic restorative treatment (ART) sealants and restorations: a meta-analysis. Clin Oral Investig. 2012 Apr;16(2):429-41. doi: 10.1007/s00784-011-0513-3. Epub 2011 Jan 28.
PMID: 21274581
citation: Banerjee A, Kidd EA, Watson TF. In vitro evaluation of five alternative methods of carious dentine excavation. Caries Res. 2000 Mar-Apr;34(2):144-50. doi: 10.1159/000016582.
PMID: 10773632
citation: van Bochove JA, van Amerongen WE. The influence of restorative treatment approaches and the use of local analgesia, on the children's discomfort. Eur Arch Paediatr Dent. 2006 Mar;7(1):11-6. doi: 10.1007/BF03320809.
PMID: 17140522
citation: Carvalho TS, van Amerongen WE, de Gee A, Bonecker M, Sampaio FC. Shear bond strengths of three glass ionomer cements to enamel and dentine. Med Oral Patol Oral Cir Bucal. 2011 May 1;16(3):e406-10. doi: 10.4317/medoral.16.e406.
PMID: 20526266
citation: Cehreli SB, Tirali RE, Yalcinkaya Z, Cehreli ZC. Microleakage of newly developed glass carbomer cement in primary teeth. Eur J Dent. 2013 Jan;7(1):15-21.
PMID: 23408469
citation: Chen X, Du M, Fan M, Mulder J, Huysmans MC, Frencken JE. Effectiveness of two new types of sealants: retention after 2 years. Clin Oral Investig. 2012 Oct;16(5):1443-50. doi: 10.1007/s00784-011-0633-9. Epub 2011 Nov 29.
PMID: 22124610
citation: van Duinen RN, Kleverlaan CJ, de Gee AJ, Werner A, Feilzer AJ. Early and long-term wear of 'fast-set' conventional glass-ionomer cements. Dent Mater. 2005 Aug;21(8):716-20. doi: 10.1016/j.dental.2004.09.007.
PMID: 16026667
citation: Ersin NK, Candan U, Aykut A, Oncag O, Eronat C, Kose T. A clinical evaluation of resin-based composite and glass ionomer cement restorations placed in primary teeth using the ART approach: results at 24 months. J Am Dent Assoc. 2006 Nov;137(11):1529-36. doi: 10.14219/jada.archive.2006.0087.
PMID: 17082278
citation: Frencken JE, Pilot T, Songpaisan Y, Phantumvanit P. Atraumatic restorative treatment (ART): rationale, technique, and development. J Public Health Dent. 1996;56(3 Spec No):135-40; discussion 161-3. doi: 10.1111/j.1752-7325.1996.tb02423.x.
PMID: 8915958
citation: Kuhnisch J, Mansmann U, Heinrich-Weltzien R, Hickel R. Longevity of materials for pit and fissure sealing--results from a meta-analysis. Dent Mater. 2012 Mar;28(3):298-303. doi: 10.1016/j.dental.2011.11.002. Epub 2011 Dec 3.
PMID: 22137936
citation: Mickenautsch S, Mount G, Yengopal V. Therapeutic effect of glass-ionomers: an overview of evidence. Aust Dent J. 2011 Mar;56(1):10-5; quiz 103. doi: 10.1111/j.1834-7819.2010.01304.x.
PMID: 21332735
citation: Raggio DP, Hesse D, Lenzi TL, Guglielmi CA, Braga MM. Is Atraumatic restorative treatment an option for restoring occlusoproximal caries lesions in primary teeth? A systematic review and meta-analysis. Int J Paediatr Dent. 2013 Nov;23(6):435-43. doi: 10.1111/ipd.12013. Epub 2012 Nov 28.
PMID: 23190278
responsible party type: Sponsor-Investigator
investigator affiliation: University of Sao Paulo
investigator full name: Daniela Prócida Raggio
investigator title: Associated Professor of Paediatric Dentistry
mesh term: Dental Caries
sharing ipd: No