<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02239991</url>
  </required_header>
  <id_info>
    <org_study_id>1986-14</org_study_id>
    <nct_id>NCT02239991</nct_id>
  </id_info>
  <brief_title>Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant</brief_title>
  <official_title>Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Hospital Israelita Albert Einstein</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Hospital Israelita Albert Einstein</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      A point-of-care bleeding management protocol based on global viscoelastic test&#xD;
      (thromboelastometry) can change the amount of blood products used during orthotopic liver&#xD;
      transplant.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Patients with liver disease frequently acquire a complex disorder of hemostasis secondary to&#xD;
      their disease.&#xD;
&#xD;
      The fundamental key to the management of coagulopathy of cirrhotic patient is the knowledge&#xD;
      that hepatic dysfunction results in impairment of both pro-hemostatic factors as&#xD;
      anti-hemostatic factors in a disproportionate manner which can lead to a clinical picture of&#xD;
      both bleeding and thrombosis.&#xD;
&#xD;
      Routine tests of coagulation as prothrombin time (PT, INR) and activated partial&#xD;
      thromboplastin time (APTT) although prolonged in cirrhotic patients cannot predict bleeding.&#xD;
&#xD;
      Global viscoelastic test of whole blood (TEG / ROTEM) produce a dynamic composite image of&#xD;
      the entire coagulation process and have the potential to provide clinically relevant&#xD;
      information in patients with liver disease allowing rational use of blood products during&#xD;
      liver transplantation.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date>September 2014</start_date>
  <completion_date type="Anticipated">February 2016</completion_date>
  <primary_completion_date type="Anticipated">August 2015</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Units of packed red blood cells (PRBCs)</measure>
    <time_frame>intraoperative</time_frame>
    <description>A prospective cohort study based on a point-of care protocol to monitor and manage the coagulopathy based on rotational thromboelastometry (ROTEM) in liver transplant with a historical control. Fifty patients will be managed by ROTEM protocol and will be compared with an equal number of historical controls treated according to the traditional protocol based on clinical and laboratory tests. The aim of this prospective study is to show a reduction in 20% of PRBCs transfusion during liver transplant.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>mortality</measure>
    <time_frame>30 days</time_frame>
    <description>All patients in interventional group will be followed for a period of 30 days.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Sepsis</measure>
    <time_frame>During intensive care unit</time_frame>
    <description>Sepsis is defined as the presence (probable or documented) of infection together with systemic manifestations of infection. All patients in interventional group will be followed for a period of 30 days.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Acute respiratory distress syndrome</measure>
    <time_frame>During intensive care unit</time_frame>
    <description>A chest X-ray will be done in all patients and will be followed for a period of 30 days. A chest X-ray can reveal which parts of your lungs have fluid in them</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Mechanical ventilation</measure>
    <time_frame>During intensive care unit</time_frame>
    <description>All patients in interventional group will be followed for a period of 30 days and will be noted the number of days under mechanical ventilation.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Intensive care unit</measure>
    <time_frame>up to 30 days</time_frame>
    <description>Length of intensive care unit stay</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">100</enrollment>
  <condition>Blood Coagulation Disorders</condition>
  <condition>Evidence of Liver Transplantation</condition>
  <condition>Liver Cirrhosis</condition>
  <arm_group>
    <arm_group_label>Historical control</arm_group_label>
    <arm_group_type>No Intervention</arm_group_type>
    <description>Group of patients that had their coagulopathy secondary to the liver transplant treated based on conventional laboratory tests. Before the implementation of thromboelastometry.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Intervention</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Group of cirrhotic bleeding patients that are treated with a bed side, point of care protocol based on thromboelastometry to guide transfusion and manage coagulopathy</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Thromboelastometry</intervention_name>
    <description>Group of cirrhotic bleeding patients that are treated with a bed side, point of care protocol based on thromboelastometry to guide transfusion and manage coagulopathy</description>
    <arm_group_label>Intervention</arm_group_label>
    <other_name>point of care bleeding management</other_name>
    <other_name>ROTEM</other_name>
    <other_name>viscoelastic test</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  all patients from the national list of liver transplant assigned to have their&#xD;
             transplant in Hospital Israelita Albert Einstein who gave free and clarified consent&#xD;
             term.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  acute liver failure&#xD;
&#xD;
          -  age under 18&#xD;
&#xD;
          -  combined transplant&#xD;
&#xD;
          -  re transplantation less than 30 days&#xD;
&#xD;
          -  incomplete medical records, more than 20% of missing data.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Luiz Henrique Ide Yamauchi, Physician</last_name>
    <role>Principal Investigator</role>
    <affiliation>Hospital Israelita Albert Einstein</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Luiz Henrique Ide Yamauchi, physician</last_name>
    <phone>+55112151-7806</phone>
    <email>luizyamauchi@gmail.com</email>
  </overall_contact>
  <location>
    <facility>
      <name>Hospital Israelita Albert Einstein</name>
      <address>
        <city>Sao Paulo</city>
        <state>SP</state>
        <zip>05652-900</zip>
        <country>Brazil</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Luiz Henrique Ide Yamauchi, Physician</last_name>
      <phone>+551121513729</phone>
      <email>luizyamauchi@gmail.com</email>
    </contact>
    <investigator>
      <last_name>Luiz Henrique Ide Yamauchi, Physician</last_name>
      <role>Principal Investigator</role>
    </investigator>
  </location>
  <location>
    <facility>
      <name>Hospital Israelita Albert Einstein</name>
      <address>
        <city>São Paulo</city>
        <state>SP</state>
        <zip>05652-000</zip>
        <country>Brazil</country>
      </address>
    </facility>
    <status>Active, not recruiting</status>
  </location>
  <location_countries>
    <country>Brazil</country>
  </location_countries>
  <reference>
    <citation>Rana A, Petrowsky H, Hong JC, Agopian VG, Kaldas FM, Farmer D, Yersiz H, Hiatt JR, Busuttil RW. Blood transfusion requirement during liver transplantation is an important risk factor for mortality. J Am Coll Surg. 2013 May;216(5):902-7. doi: 10.1016/j.jamcollsurg.2012.12.047. Epub 2013 Mar 9.</citation>
    <PMID>23478547</PMID>
  </reference>
  <reference>
    <citation>Maxwell MJ, Wilson MJA. Complications of blood transfusion. Continuing Education in Anaesthesia. Crit Care Pain 2006; 6: 225-229</citation>
  </reference>
  <reference>
    <citation>Massicotte L, Sassine MP, Lenis S, Roy A. Transfusion predictors in liver transplant. Anesth Analg. 2004 May;98(5):1245-51, table of contents. doi: 10.1213/01.ane.0000111184.21278.07.</citation>
    <PMID>15105195</PMID>
  </reference>
  <reference>
    <citation>Liu LL, Niemann CU. Intraoperative management of liver transplant patients. Transplant Rev (Orlando). 2011 Jul;25(3):124-9. doi: 10.1016/j.trre.2010.10.006. Epub 2011 Apr 21.</citation>
    <PMID>21514137</PMID>
  </reference>
  <reference>
    <citation>Ozier Y, Pessione F, Samain E, Courtois F; French Study Group on Blood Transfusion in Liver Transplantation. Institutional variability in transfusion practice for liver transplantation. Anesth Analg. 2003 Sep;97(3):671-679. doi: 10.1213/01.ANE.0000073354.38695.7C.</citation>
    <PMID>12933381</PMID>
  </reference>
  <reference>
    <citation>de Boer MT, Christensen MC, Asmussen M, van der Hilst CS, Hendriks HG, Slooff MJ, Porte RJ. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth Analg. 2008 Jan;106(1):32-44, table of contents. doi: 10.1213/01.ane.0000289638.26666.ed.</citation>
    <PMID>18165548</PMID>
  </reference>
  <reference>
    <citation>Liu S, Fan J, Wang X, Gong Z, Wang S, Huang L, Xing T, Li T, Peng Z, Sun X. Intraoperative cryoprecipitate transfusion and its association with the incidence of biliary complications after liver transplantation--a retrospective cohort study. PLoS One. 2013 May 10;8(5):e60727. doi: 10.1371/journal.pone.0060727. Print 2013.</citation>
    <PMID>23675406</PMID>
  </reference>
  <reference>
    <citation>Ramos E, Dalmau A, Sabate A, Lama C, Llado L, Figueras J, Jaurrieta E. Intraoperative red blood cell transfusion in liver transplantation: influence on patient outcome, prediction of requirements, and measures to reduce them. Liver Transpl. 2003 Dec;9(12):1320-7. doi: 10.1016/jlts.2003.50204.</citation>
    <PMID>14625833</PMID>
  </reference>
  <reference>
    <citation>Cacciarelli TV, Keeffe EB, Moore DH, Burns W, Busque S, Concepcion W, So SK, Esquivel CO. Effect of intraoperative blood transfusion on patient outcome in hepatic transplantation. Arch Surg. 1999 Jan;134(1):25-9. doi: 10.1001/archsurg.134.1.25.</citation>
    <PMID>9927126</PMID>
  </reference>
  <reference>
    <citation>Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP. Transfusion medicine. First of two parts--blood transfusion. N Engl J Med. 1999 Feb 11;340(6):438-47. doi: 10.1056/NEJM199902113400606. No abstract available.</citation>
    <PMID>9971869</PMID>
  </reference>
  <reference>
    <citation>Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP. Transfusion medicine. Second of two parts--blood conservation. N Engl J Med. 1999 Feb 18;340(7):525-33. doi: 10.1056/NEJM199902183400706. No abstract available.</citation>
    <PMID>10021474</PMID>
  </reference>
  <reference>
    <citation>Spahn DR, Casutt M. Eliminating blood transfusions: new aspects and perspectives. Anesthesiology. 2000 Jul;93(1):242-55. doi: 10.1097/00000542-200007000-00035. No abstract available.</citation>
    <PMID>10861168</PMID>
  </reference>
  <reference>
    <citation>Weber CF, Gorlinger K, Meininger D, Herrmann E, Bingold T, Moritz A, Cohn LH, Zacharowski K. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology. 2012 Sep;117(3):531-47. doi: 10.1097/ALN.0b013e318264c644.</citation>
    <PMID>22914710</PMID>
  </reference>
  <reference>
    <citation>Davenport R, Khan S. Management of major trauma haemorrhage: treatment priorities and controversies. Br J Haematol. 2011 Dec;155(5):537-48. doi: 10.1111/j.1365-2141.2011.08885.x. Epub 2011 Oct 21.</citation>
    <PMID>22017416</PMID>
  </reference>
  <reference>
    <citation>Saner FH, Gieseler RK, Akiz H, Canbay A, Gorlinger K. Delicate balance of bleeding and thrombosis in end-stage liver disease and liver transplantation. Digestion. 2013;88(3):135-44. doi: 10.1159/000354400. Epub 2013 Sep 5.</citation>
    <PMID>24008288</PMID>
  </reference>
  <reference>
    <citation>Tripodi A, Salerno F, Chantarangkul V, Clerici M, Cazzaniga M, Primignani M, Mannuccio Mannucci P. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology. 2005 Mar;41(3):553-8. doi: 10.1002/hep.20569.</citation>
    <PMID>15726661</PMID>
  </reference>
  <reference>
    <citation>Kang YG, Martin DJ, Marquez J, Lewis JH, Bontempo FA, Shaw BW Jr, Starzl TE, Winter PM. Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesth Analg. 1985 Sep;64(9):888-96.</citation>
    <PMID>3896028</PMID>
  </reference>
  <reference>
    <citation>Trzebicki J, Flakiewicz E, Kosieradzki M, Blaszczyk B, Kolacz M, Jureczko L, Pacholczyk M, Chmura A, Lagiewska B, Lisik W, Wasiak D, Kosson D, Kwiatkowski A, Lazowski T. The use of thromboelastometry in the assessment of hemostasis during orthotopic liver transplantation reduces the demand for blood products. Ann Transplant. 2010 Jul-Sep;15(3):19-24.</citation>
    <PMID>20877262</PMID>
  </reference>
  <reference>
    <citation>Agarwal A, Sharma N, Vij V. Point-of-care coagulation monitoring during liver transplantation. Trends in Anaesth and Crit Care. 2013;3:42-48.</citation>
  </reference>
  <reference>
    <citation>Blasi A, Beltran J, Pereira A, Martinez-Palli G, Torrents A, Balust J, Zavala E, Taura P, Garcia-Valdecasas JC. An assessment of thromboelastometry to monitor blood coagulation and guide transfusion support in liver transplantation. Transfusion. 2012 Sep;52(9):1989-98. doi: 10.1111/j.1537-2995.2011.03526.x. Epub 2012 Feb 5.</citation>
    <PMID>22304465</PMID>
  </reference>
  <reference>
    <citation>McCluskey SA, Karkouti K, Wijeysundera DN, Kakizawa K, Ghannam M, Hamdy A, Grant D, Levy G. Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation. Liver Transpl. 2006 Nov;12(11):1584-93. doi: 10.1002/lt.20868.</citation>
    <PMID>16952177</PMID>
  </reference>
  <reference>
    <citation>Ganter MT, Hofer CK. Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg. 2008 May;106(5):1366-75. doi: 10.1213/ane.0b013e318168b367.</citation>
    <PMID>18420846</PMID>
  </reference>
  <reference>
    <citation>Bauters A, Mazoyer E. Apport de la thromboe ́lastome ́trie rotative (ROTEM) pour l'exploration de l'he ́mostase: inte ́reˆt en pratique clinique. Revue francophone des laboratoires 2007; 393: 45-50</citation>
  </reference>
  <reference>
    <citation>Luddington RJ. Thrombelastography/thromboelastometry. Clin Lab Haematol. 2005 Apr;27(2):81-90. doi: 10.1111/j.1365-2257.2005.00681.x.</citation>
    <PMID>15784122</PMID>
  </reference>
  <reference>
    <citation>Tanaka KA, Bader SO, Gorlinger K. Novel approaches in management of perioperative coagulopathy. Curr Opin Anaesthesiol. 2014 Feb;27(1):72-80. doi: 10.1097/ACO.0000000000000025.</citation>
    <PMID>24263685</PMID>
  </reference>
  <reference>
    <citation>Tanaka KA, Bolliger D, Vadlamudi R, Nimmo A. Rotational thromboelastometry (ROTEM)-based coagulation management in cardiac surgery and major trauma. J Cardiothorac Vasc Anesth. 2012 Dec;26(6):1083-93. doi: 10.1053/j.jvca.2012.06.015. Epub 2012 Aug 3. No abstract available.</citation>
    <PMID>22863406</PMID>
  </reference>
  <reference>
    <citation>Romero FA, Razonable RR. Infections in liver transplant recipients. World J Hepatol. 2011 Apr 27;3(4):83-92. doi: 10.4254/wjh.v3.i4.83.</citation>
    <PMID>21603030</PMID>
  </reference>
  <verification_date>September 2014</verification_date>
  <study_first_submitted>September 3, 2014</study_first_submitted>
  <study_first_submitted_qc>September 11, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 15, 2014</study_first_posted>
  <last_update_submitted>September 15, 2014</last_update_submitted>
  <last_update_submitted_qc>September 15, 2014</last_update_submitted_qc>
  <last_update_posted type="Estimate">September 17, 2014</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Hospital Israelita Albert Einstein</investigator_affiliation>
    <investigator_full_name>Luiz Henrique Ide Yamauchi</investigator_full_name>
    <investigator_title>Physician</investigator_title>
  </responsible_party>
  <keyword>Point of care</keyword>
  <keyword>perioperative hemostasis</keyword>
  <keyword>thromboelastometry</keyword>
  <keyword>bleeding risk</keyword>
  <keyword>end-stage liver disease</keyword>
  <keyword>hepatic coagulopathy</keyword>
  <keyword>whole blood coagulation</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Liver Cirrhosis</mesh_term>
    <mesh_term>Hemostatic Disorders</mesh_term>
    <mesh_term>Blood Coagulation Disorders</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02239991
org study id: 1986-14
nct id: NCT02239991
lead sponsor: 
has dmc: No
A point-of-care bleeding management protocol based on global viscoelastic test
      (thromboelastometry) can change the amount of blood products used during orthotopic liver
      transplant.
Patients with liver disease frequently acquire a complex disorder of hemostasis secondary to
      their disease.

      The fundamental key to the management of coagulopathy of cirrhotic patient is the knowledge
      that hepatic dysfunction results in impairment of both pro-hemostatic factors as
      anti-hemostatic factors in a disproportionate manner which can lead to a clinical picture of
      both bleeding and thrombosis.

      Routine tests of coagulation as prothrombin time (PT, INR) and activated partial
      thromboplastin time (APTT) although prolonged in cirrhotic patients cannot predict bleeding.

      Global viscoelastic test of whole blood (TEG / ROTEM) produce a dynamic composite image of
      the entire coagulation process and have the potential to provide clinically relevant
      information in patients with liver disease allowing rational use of blood products during
      liver transplantation.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Units of packed red blood cells (PRBCs)
time frame: intraoperative
description: A prospective cohort study based on a point-of care protocol to monitor and manage the coagulopathy based on rotational thromboelastometry (ROTEM) in liver transplant with a historical control. Fifty patients will be managed by ROTEM protocol and will be compared with an equal number of historical controls treated according to the traditional protocol based on clinical and laboratory tests. The aim of this prospective study is to show a reduction in 20% of PRBCs transfusion during liver transplant.
measure: mortality
time frame: 30 days
description: All patients in interventional group will be followed for a period of 30 days.
measure: Sepsis
time frame: During intensive care unit
description: Sepsis is defined as the presence (probable or documented) of infection together with systemic manifestations of infection. All patients in interventional group will be followed for a period of 30 days.
measure: Acute respiratory distress syndrome
time frame: During intensive care unit
description: A chest X-ray will be done in all patients and will be followed for a period of 30 days. A chest X-ray can reveal which parts of your lungs have fluid in them
measure: Mechanical ventilation
time frame: During intensive care unit
description: All patients in interventional group will be followed for a period of 30 days and will be noted the number of days under mechanical ventilation.
measure: Intensive care unit
time frame: up to 30 days
description: Length of intensive care unit stay
arm group label: Historical control
arm group type: No Intervention
description: Group of patients that had their coagulopathy secondary to the liver transplant treated based on conventional laboratory tests. Before the implementation of thromboelastometry.
arm group label: Intervention
arm group type: Experimental
description: Group of cirrhotic bleeding patients that are treated with a bed side, point of care protocol based on thromboelastometry to guide transfusion and manage coagulopathy
intervention type: Procedure
intervention name: Thromboelastometry
description: Group of cirrhotic bleeding patients that are treated with a bed side, point of care protocol based on thromboelastometry to guide transfusion and manage coagulopathy
arm group label: Intervention
other name: point of care bleeding management
other name: ROTEM
other name: viscoelastic test
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Luiz Henrique Ide Yamauchi, Physician
role: Principal Investigator
affiliation: Hospital Israelita Albert Einstein
last name: Luiz Henrique Ide Yamauchi, physician
phone: +55112151-7806
email: luizyamauchi@gmail.com
facility: 
status: Recruiting
contact: 
investigator: 
facility: 
status: Active, not recruiting
country: Brazil
citation: Rana A, Petrowsky H, Hong JC, Agopian VG, Kaldas FM, Farmer D, Yersiz H, Hiatt JR, Busuttil RW. Blood transfusion requirement during liver transplantation is an important risk factor for mortality. J Am Coll Surg. 2013 May;216(5):902-7. doi: 10.1016/j.jamcollsurg.2012.12.047. Epub 2013 Mar 9.
PMID: 23478547
citation: Maxwell MJ, Wilson MJA. Complications of blood transfusion. Continuing Education in Anaesthesia. Crit Care Pain 2006; 6: 225-229
citation: Massicotte L, Sassine MP, Lenis S, Roy A. Transfusion predictors in liver transplant. Anesth Analg. 2004 May;98(5):1245-51, table of contents. doi: 10.1213/01.ane.0000111184.21278.07.
PMID: 15105195
citation: Liu LL, Niemann CU. Intraoperative management of liver transplant patients. Transplant Rev (Orlando). 2011 Jul;25(3):124-9. doi: 10.1016/j.trre.2010.10.006. Epub 2011 Apr 21.
PMID: 21514137
citation: Ozier Y, Pessione F, Samain E, Courtois F; French Study Group on Blood Transfusion in Liver Transplantation. Institutional variability in transfusion practice for liver transplantation. Anesth Analg. 2003 Sep;97(3):671-679. doi: 10.1213/01.ANE.0000073354.38695.7C.
PMID: 12933381
citation: de Boer MT, Christensen MC, Asmussen M, van der Hilst CS, Hendriks HG, Slooff MJ, Porte RJ. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth Analg. 2008 Jan;106(1):32-44, table of contents. doi: 10.1213/01.ane.0000289638.26666.ed.
PMID: 18165548
citation: Liu S, Fan J, Wang X, Gong Z, Wang S, Huang L, Xing T, Li T, Peng Z, Sun X. Intraoperative cryoprecipitate transfusion and its association with the incidence of biliary complications after liver transplantation--a retrospective cohort study. PLoS One. 2013 May 10;8(5):e60727. doi: 10.1371/journal.pone.0060727. Print 2013.
PMID: 23675406
citation: Ramos E, Dalmau A, Sabate A, Lama C, Llado L, Figueras J, Jaurrieta E. Intraoperative red blood cell transfusion in liver transplantation: influence on patient outcome, prediction of requirements, and measures to reduce them. Liver Transpl. 2003 Dec;9(12):1320-7. doi: 10.1016/jlts.2003.50204.
PMID: 14625833
citation: Cacciarelli TV, Keeffe EB, Moore DH, Burns W, Busque S, Concepcion W, So SK, Esquivel CO. Effect of intraoperative blood transfusion on patient outcome in hepatic transplantation. Arch Surg. 1999 Jan;134(1):25-9. doi: 10.1001/archsurg.134.1.25.
PMID: 9927126
citation: Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP. Transfusion medicine. First of two parts--blood transfusion. N Engl J Med. 1999 Feb 11;340(6):438-47. doi: 10.1056/NEJM199902113400606. No abstract available.
PMID: 9971869
citation: Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP. Transfusion medicine. Second of two parts--blood conservation. N Engl J Med. 1999 Feb 18;340(7):525-33. doi: 10.1056/NEJM199902183400706. No abstract available.
PMID: 10021474
citation: Spahn DR, Casutt M. Eliminating blood transfusions: new aspects and perspectives. Anesthesiology. 2000 Jul;93(1):242-55. doi: 10.1097/00000542-200007000-00035. No abstract available.
PMID: 10861168
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responsible party type: Principal Investigator
investigator affiliation: Hospital Israelita Albert Einstein
investigator full name: Luiz Henrique Ide Yamauchi
investigator title: Physician
mesh term: Liver Cirrhosis
mesh term: Hemostatic Disorders
mesh term: Blood Coagulation Disorders