<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02241213</url>
  </required_header>
  <id_info>
    <org_study_id>fcv-Aphasia</org_study_id>
    <secondary_id>656656933492</secondary_id>
    <nct_id>NCT02241213</nct_id>
  </id_info>
  <brief_title>Effects of MTS-r on Speech Production in Non-fluent Aphasia Post-ischemic Stroke Patients</brief_title>
  <acronym>Aphasia-ACV</acronym>
  <official_title>Effects of Repetitive Magnetic Transcranial Stimulation of Low Frequency on Speech Production in Patients With Non-fluent Aphasia Post-ischemic Stroke</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Fundación Cardiovascular de Colombia</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología (COLCIENCIAS)</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>Fundación Cardiovascular de Colombia</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      Aphasia is one of the most disabling complications in language production in patients with&#xD;
      left hemisphere stroke. About 19% of patients who experience aphasia may have a spontaneously&#xD;
      recovery after several weeks or months. Some studies have reported that repetitive low&#xD;
      frequency Transcranial Magnetic Stimulation (TMS-r) in patients with ischemic stroke&#xD;
      generates left modulation of cortical excitability by facilitating and promoting functional&#xD;
      reorganization and recovery of language production. In spite of this, most of the studies in&#xD;
      patients with post-stroke aphasia, are small cases series without controls that correspond to&#xD;
      a descriptive design and does not perform long-term follow up. Currently the population is&#xD;
      heterogeneous respect to etiology, type of stroke and aphasia severity; also several authors&#xD;
      have concluded that the exact location of the site, would be possible through the&#xD;
      neuronavigation technique, to obtain better results.&#xD;
&#xD;
      OVERALL OBJECTIVE Determine the efficacy of repetitive low-frequency TMS on oral language&#xD;
      recovery in post-ischemic stroke patients with non-fluent aphasia&#xD;
&#xD;
      ESPECIFIC OBJETIVES&#xD;
&#xD;
        -  Estimate the effect of repetitiveTMS treatment on right Lowe Frontal Gyrus (GFI), in the&#xD;
           evolution of the neuropsychological language test results in patients with non-fluent&#xD;
           aphasia, compared to placebo.&#xD;
&#xD;
        -  Describe the behavior of depression and anxiety levels in both treatment groups (active&#xD;
           and placebo), through Zung anxiety and depression test, to establish their correlation&#xD;
           with production testing language.&#xD;
&#xD;
        -  Evaluate the effect of repetitiveTMS technique compared to placebo, on the overall&#xD;
           functionality of the subject through Barthel scale.&#xD;
&#xD;
        -  Describe the impact of language behavior on the quality of life of patients treated with&#xD;
           placebo and active EMT, assessed by the EuroQol test.&#xD;
&#xD;
      METHODOLOGY A placebo double blind controlled and randomize trial, to evaluate the efficacy&#xD;
      of low frequency EMT-r in language recovery in 100 patients with first ischemic stroke event&#xD;
      among the first 4-8 months postinfarction and non-fluent aphasia. The patient will agree and&#xD;
      will sign the informed consent, in order to application aphasia diagnosis Boston test,&#xD;
      Edinburgh test, Barthel scale, Zung anxiety and depression test, and EuroQol scale, Neuropsi.&#xD;
      Subsequently the subjects will be randomizate to any of two arms of the study. A week before&#xD;
      the start of the stimulation sessions, the following tests will be applied to assess language&#xD;
      production: Boston Test and Verbal Fluency (FAS). Each patient will have a daily session&#xD;
      EMT-r low-frequency active or inactive coil with a biphasic stimulator pulses applied for ten&#xD;
      days in two weeks on the triangular area - homologous to injury Lower Front Gyrus (LFG),&#xD;
      (right brain hemisphere). Complete the treatment schedule of two weeks, the language&#xD;
      production will be evaluate again, and also scales as Barthel an Rankin-m, Zung anxiety and&#xD;
      depression and EuroQol. This monitoring will be achieved in five stages: after one week, one&#xD;
      month, 4 months, 8 months and 12 months post-stimulation, with the intention of determining&#xD;
      the duration and effectiveness effects in language production of the EMT-r.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Some studies have reported that low frequency repetitive Transcranial Magnetic Stimulation in&#xD;
      patients with ischemic stroke generates left modulation of cortical excitability by&#xD;
      facilitating, and promoting functional reorganization and facilitate the language production.&#xD;
&#xD;
      Stroke is a major public health problem, one-third of patients do not survive the first year&#xD;
      after the vascular event, cause of severe disability and also is the third leading cause of&#xD;
      death worldwide. Two-thirds of the survivors have neurologic deficits including aphasia (19%)&#xD;
      generating functional disability, compromise on their daily living activities, and impact on&#xD;
      the quality of life (93% of patients with aphasia after stroke compared with 50% of those&#xD;
      survive without aphasia). Aphasia is an additional risk factor for depression (prevalence&#xD;
      5-63%), and also interfering with the functional and cognitive recovery, increasing the risk&#xD;
      of mortality.&#xD;
&#xD;
      Generally the treatment of aphasia is based on speech therapy and drug therapy oriented&#xD;
      comorbidities such as depression or anxiety. However, it has studied different interventions&#xD;
      in an effort to improve the speech recovery of aphasia, as Transcranial Magnetic Stimulation&#xD;
      (TMS), which facilitates recovery by stimulating contralesional and lesional regions. Most&#xD;
      studies have been based on the transcallosal disinhibition theory, which consist on blocking&#xD;
      homotopic regions through low frequency stimulation in the right posterior GFI (triangular&#xD;
      portion) to produce a GFI disinhibition from right to left and facilitate neuroplasticity&#xD;
      brain process.&#xD;
&#xD;
      EMT technique is based on the principle of electromagnetic induction, proposed by Michael&#xD;
      Faraday (1831), in which posits that magnetic field depends on the stimulation time,&#xD;
      generating an electric field that eventually causes neuronal excitability.The strength of the&#xD;
      electric current produced in the coil between 5-10 Ka (Kiloamperes), while the strength of&#xD;
      the induced magnetic field is about 1 to 2 Tesla, and the cortical area to stimulated is&#xD;
      about 3 cm² and 2 cm depth. The magnetic field generated may have sufficient magnitude and&#xD;
      density to depolarize cortical neurons tract, directly through axonal cone or indirectly&#xD;
      through interneurons. When TMS pulses are applied repeatedly, which is known as repetitive&#xD;
      TMS (r-TMS) produce modulation of the cortical excitability, increasing or decreasing,&#xD;
      depending on the stimulation parameters. Those effects may persist beyond the train&#xD;
      stimulation; defined as repetitive series of regular pulses.&#xD;
&#xD;
      Fundamental mechanisms of EMT, are not yet fully understood, because due inter-session and&#xD;
      inter-subject variability have been observed in the modulation of induced excitability. The&#xD;
      EMT-r may also induce changes in hormonal and neurotransmitter systems, such as, serotonin,&#xD;
      dopamine, NMDA receptors, taurine, aspartate, serine axis and can regulate the expression of&#xD;
      some genes; cfos, c-jung, which are important for synaptic plasticity. It has been studied&#xD;
      several possible mechanisms involved in the functional regulation exerted by the EMT-r, such&#xD;
      as synaptic plasticity, which is the most explored one, changes in excitability of neuronal&#xD;
      networks, activation of feedback loops and metaplasticity, understood plasticity as synaptic&#xD;
      plasticity. However, although but not yet, been established whether the source of the&#xD;
      clinical benefit of any scheme of stimulation is a direct or indirect result of the&#xD;
      modulation of the excitability, is believed to be associated with neuromodulators release and&#xD;
      growth factors such as neurotrophic factor derived from the brain, which play an important&#xD;
      role in the mechanism of EMT.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date>August 2014</start_date>
  <completion_date type="Anticipated">December 2017</completion_date>
  <primary_completion_date type="Anticipated">August 2017</primary_completion_date>
  <phase>Phase 3</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Triple (Participant, Care Provider, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Boston-test for aphasia diagnosis</measure>
    <time_frame>3 years</time_frame>
    <description>Evaluates the different domains of language to determine the severity degree of aphasia. Applicable in patients from 16 years old and its duration is approximately 90 minutes. This test has various scales such as intonation, phrase extension, language articulation, grammar, paraphasias, repetition, word search and listening</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Zung- Depression and anxiety</measure>
    <time_frame>3 years</time_frame>
    <description>Evaluates the level of depression in patients with a depressive disorder. This scale is conformed by 20 items assessing 4 common characteristics of depression: the dominant effect, physiological equivalents, other disturbances, and psychomotor activities. Each question is rated on a scale of 1-4 categorized in (1 = few times, 2 = some times, 3 = a good part of the time and 4 = most of the time). The score range is 20-80. Where scores between 5-49 equivalent to a normal range; 50-59 slightly depressed; 60-69 moderately depressed and severely depressed 70 or more [56].</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Barthel-Scale</measure>
    <time_frame>3 Years</time_frame>
    <description>Instrument for measuring the basic activities of daily living (ADL), used especially in patients with acute cerebrovascular disease. Rate the ability of a person to perform in a dependent or independent 10 ABVD, assigning a score (0, 5, 10,15) depending on the time spent on its implementation and the need for help to carry it out. The final score ranges from 0 to 100 where the values are equivalent to between 95-100 independent.; 91-99 mild dependent; 61-90: moderately dependent; 21-60; dependent grave; 0-20 totally dependent [57].</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Scale quality of life (EuroQol, EQ-5D)</measure>
    <time_frame>3 Years</time_frame>
    <description>Evaluate two aspects:The first is the description of the state of health in five dimensions (mobility, self-care, usual activities, pain / discomfort and anxiety / depression), each of which is defined with three levels of severity, as measured by a Likert scale (no problems, some problems and many problems or inability to activity) type. The state of health of the individual is a combination of severity in each five dimensions, expressed by a numerical data. On the other hand, in the second part of the questionnaire the subject must score on a visual millimeter analogue scale his auto perception condition health at the time, considering the ends of the scale as the worst health status (0) and better health [61, 62]</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Edinburgh-Scale</measure>
    <time_frame>3 Years</time_frame>
    <description>Is used to assess handedness in daily activities. This inventory can be scored through observation or patient self-report. Interpretation: scores below -40 correspond to left dominance; scores between -40 and +40 is ambidextrous and above +40 right dominance [55].</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Verbal Fluency Test (FAS)</measure>
    <time_frame>3 Years</time_frame>
    <description>Evaluates the spontaneous production of words under restricted search of verbal fluency association. To evaluate phonological fluency, the patient must produce orally as many words as possible starting with certain letter in a determined period of time, a minute. While for evaluating semantic fluency, will be asked to the patient to name as many animals and fruits as possible in one minute. The score takes into account the total amount of words correctly produced for both categories, and further the number of perseverations, referrals, paraphasias [58] and own names.</description>
  </other_outcome>
  <other_outcome>
    <measure>Brief Neuropsychological Battery (NEUROPSI)</measure>
    <time_frame>3 Years</time_frame>
    <description>Provides quantitative and qualitative data. Provides a cognitive profile of the patient and allows individual scores for each area, the cognitive domains assessed are: orientation, attention and concentration, leguaje, memory, executive functions, reading, writing, arithmetic. A gradient of severity of cognitive impairment, with an operating range that includes normal and mild, moderate and severe disorders is obtained. It is based on solid normative data that allow comparison and correction according to age and education.</description>
  </other_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">100</enrollment>
  <condition>Aphasia, Broca</condition>
  <arm_group>
    <arm_group_label>Active Transcranial Magnetic Stimulation TMS- r</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Application of single stimulation pulses and regularly repeated ones, the frequency may be divided into high frequency EMT (&gt; 1 Hz), low frequency (&lt;1 Hz) This classification is based on physiological effects (stimulation or inhibition neuronal respectively). In this particular case, we will use low frequency &lt;1 Hz with repetitive pulses.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Placebo Transcranial Magnetic Stimulation</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Placebo coil that will simulate the sound of the pulses.</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Transcranial Magnetic Stimulation (TMS-r)</intervention_name>
    <description>10 sessions, each session of EMT-r will be low frequency (1 Hz for 20 minutes and a total of 1200 pulses) using a biphasic pulse stimulator, with active coil (coil-shaped focal or inactive coil &quot;placebo&quot; for 2 weeks from Monday to Friday, target: triangular portion - homologous to injury Inferior front Gyrus (GFI).</description>
    <arm_group_label>Active Transcranial Magnetic Stimulation TMS- r</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Placebo Transcranial Magnetic Stimulation</intervention_name>
    <description>10 sesions of Non- active coil, that will simulate the sound of the TMS, holding the coil on the scalp at an angle of 45 degrees in the selected area</description>
    <arm_group_label>Placebo Transcranial Magnetic Stimulation</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Men and women age range from 50-70 years.&#xD;
&#xD;
          -  School-level equal to or more than 5 years approved.&#xD;
&#xD;
          -  Right hand dominance, determined through the Edinburgh Inventory (score above 40) .&#xD;
&#xD;
          -  Ischemic stroke, at the territory of the left middle cerebral artery (MCA - Left).&#xD;
&#xD;
          -  Aphasia diagnosis determined by the test for aphasia Boston.&#xD;
&#xD;
          -  Patients who have previously received speech therapy&#xD;
&#xD;
          -  Patients who gave their written informed consent&#xD;
&#xD;
        Exclusion Criteria: Criteria defined by Wasserman, 1995 [59, 60] for rTMS:&#xD;
&#xD;
          -  Pre-symptomatic diagnosis of stroke in more than one occasion.&#xD;
&#xD;
          -  Diagnosis of neurodegenerative diseases such dementia and Parkinson's disease.&#xD;
&#xD;
          -  Pre- Epilepsy diagnosis&#xD;
&#xD;
          -  Diagnosis of Diabetes Mellitus Type I or II&#xD;
&#xD;
          -  Diagnosis of liver disease or renal&#xD;
&#xD;
          -  Diagnosis of Diseases-terminal to prevent tracking&#xD;
&#xD;
          -  Diagnosis of psychiatric illnesses such as major depressive disorder (MDD) or other.&#xD;
&#xD;
          -  Global cognitive impairment or previous diagnosis of dementia&#xD;
&#xD;
          -  Visual or auditory deficit&#xD;
&#xD;
          -  Patients with metal implants, cardiac pacemakers or drug infusion pumps.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>50 Years</minimum_age>
    <maximum_age>70 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Federico A Silva, MD,MSc</last_name>
    <role>Principal Investigator</role>
    <affiliation>Fundacion Cardiovascular de Colombia</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Federico A Silva, MD,MSc</last_name>
    <phone>037- 639-9292</phone>
    <phone_ext>255</phone_ext>
    <email>federicosilva@fcv.org</email>
  </overall_contact>
  <location>
    <facility>
      <name>Fundacion Cardiovascular de Colombia</name>
      <address>
        <city>Bucaramanga</city>
        <state>Santander</state>
        <zip>0000</zip>
        <country>Colombia</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Federico A Silva, MD,MSc</last_name>
      <phone>037-639-9292</phone>
      <phone_ext>255</phone_ext>
      <email>federicosilva@fcv.org</email>
    </contact>
    <investigator>
      <last_name>Federico A Silva</last_name>
      <role>Principal Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>Colombia</country>
  </location_countries>
  <verification_date>September 2014</verification_date>
  <study_first_submitted>July 9, 2014</study_first_submitted>
  <study_first_submitted_qc>September 12, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 16, 2014</study_first_posted>
  <last_update_submitted>September 12, 2014</last_update_submitted>
  <last_update_submitted_qc>September 12, 2014</last_update_submitted_qc>
  <last_update_posted type="Estimate">September 16, 2014</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Stroke</keyword>
  <keyword>Aphasia</keyword>
  <keyword>Broca</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Ischemic Stroke</mesh_term>
    <mesh_term>Aphasia</mesh_term>
    <mesh_term>Aphasia, Broca</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02241213
org study id: fcv-Aphasia
secondary id: 656656933492
nct id: NCT02241213
lead sponsor: 
collaborator: 
has dmc: Yes
Aphasia is one of the most disabling complications in language production in patients with
      left hemisphere stroke. About 19% of patients who experience aphasia may have a spontaneously
      recovery after several weeks or months. Some studies have reported that repetitive low
      frequency Transcranial Magnetic Stimulation (TMS-r) in patients with ischemic stroke
      generates left modulation of cortical excitability by facilitating and promoting functional
      reorganization and recovery of language production. In spite of this, most of the studies in
      patients with post-stroke aphasia, are small cases series without controls that correspond to
      a descriptive design and does not perform long-term follow up. Currently the population is
      heterogeneous respect to etiology, type of stroke and aphasia severity; also several authors
      have concluded that the exact location of the site, would be possible through the
      neuronavigation technique, to obtain better results.

      OVERALL OBJECTIVE Determine the efficacy of repetitive low-frequency TMS on oral language
      recovery in post-ischemic stroke patients with non-fluent aphasia

      ESPECIFIC OBJETIVES

        -  Estimate the effect of repetitiveTMS treatment on right Lowe Frontal Gyrus (GFI), in the
           evolution of the neuropsychological language test results in patients with non-fluent
           aphasia, compared to placebo.

        -  Describe the behavior of depression and anxiety levels in both treatment groups (active
           and placebo), through Zung anxiety and depression test, to establish their correlation
           with production testing language.

        -  Evaluate the effect of repetitiveTMS technique compared to placebo, on the overall
           functionality of the subject through Barthel scale.

        -  Describe the impact of language behavior on the quality of life of patients treated with
           placebo and active EMT, assessed by the EuroQol test.

      METHODOLOGY A placebo double blind controlled and randomize trial, to evaluate the efficacy
      of low frequency EMT-r in language recovery in 100 patients with first ischemic stroke event
      among the first 4-8 months postinfarction and non-fluent aphasia. The patient will agree and
      will sign the informed consent, in order to application aphasia diagnosis Boston test,
      Edinburgh test, Barthel scale, Zung anxiety and depression test, and EuroQol scale, Neuropsi.
      Subsequently the subjects will be randomizate to any of two arms of the study. A week before
      the start of the stimulation sessions, the following tests will be applied to assess language
      production: Boston Test and Verbal Fluency (FAS). Each patient will have a daily session
      EMT-r low-frequency active or inactive coil with a biphasic stimulator pulses applied for ten
      days in two weeks on the triangular area - homologous to injury Lower Front Gyrus (LFG),
      (right brain hemisphere). Complete the treatment schedule of two weeks, the language
      production will be evaluate again, and also scales as Barthel an Rankin-m, Zung anxiety and
      depression and EuroQol. This monitoring will be achieved in five stages: after one week, one
      month, 4 months, 8 months and 12 months post-stimulation, with the intention of determining
      the duration and effectiveness effects in language production of the EMT-r.
Some studies have reported that low frequency repetitive Transcranial Magnetic Stimulation in
      patients with ischemic stroke generates left modulation of cortical excitability by
      facilitating, and promoting functional reorganization and facilitate the language production.

      Stroke is a major public health problem, one-third of patients do not survive the first year
      after the vascular event, cause of severe disability and also is the third leading cause of
      death worldwide. Two-thirds of the survivors have neurologic deficits including aphasia (19%)
      generating functional disability, compromise on their daily living activities, and impact on
      the quality of life (93% of patients with aphasia after stroke compared with 50% of those
      survive without aphasia). Aphasia is an additional risk factor for depression (prevalence
      5-63%), and also interfering with the functional and cognitive recovery, increasing the risk
      of mortality.

      Generally the treatment of aphasia is based on speech therapy and drug therapy oriented
      comorbidities such as depression or anxiety. However, it has studied different interventions
      in an effort to improve the speech recovery of aphasia, as Transcranial Magnetic Stimulation
      (TMS), which facilitates recovery by stimulating contralesional and lesional regions. Most
      studies have been based on the transcallosal disinhibition theory, which consist on blocking
      homotopic regions through low frequency stimulation in the right posterior GFI (triangular
      portion) to produce a GFI disinhibition from right to left and facilitate neuroplasticity
      brain process.

      EMT technique is based on the principle of electromagnetic induction, proposed by Michael
      Faraday (1831), in which posits that magnetic field depends on the stimulation time,
      generating an electric field that eventually causes neuronal excitability.The strength of the
      electric current produced in the coil between 5-10 Ka (Kiloamperes), while the strength of
      the induced magnetic field is about 1 to 2 Tesla, and the cortical area to stimulated is
      about 3 cm² and 2 cm depth. The magnetic field generated may have sufficient magnitude and
      density to depolarize cortical neurons tract, directly through axonal cone or indirectly
      through interneurons. When TMS pulses are applied repeatedly, which is known as repetitive
      TMS (r-TMS) produce modulation of the cortical excitability, increasing or decreasing,
      depending on the stimulation parameters. Those effects may persist beyond the train
      stimulation; defined as repetitive series of regular pulses.

      Fundamental mechanisms of EMT, are not yet fully understood, because due inter-session and
      inter-subject variability have been observed in the modulation of induced excitability. The
      EMT-r may also induce changes in hormonal and neurotransmitter systems, such as, serotonin,
      dopamine, NMDA receptors, taurine, aspartate, serine axis and can regulate the expression of
      some genes; cfos, c-jung, which are important for synaptic plasticity. It has been studied
      several possible mechanisms involved in the functional regulation exerted by the EMT-r, such
      as synaptic plasticity, which is the most explored one, changes in excitability of neuronal
      networks, activation of feedback loops and metaplasticity, understood plasticity as synaptic
      plasticity. However, although but not yet, been established whether the source of the
      clinical benefit of any scheme of stimulation is a direct or indirect result of the
      modulation of the excitability, is believed to be associated with neuromodulators release and
      growth factors such as neurotrophic factor derived from the brain, which play an important
      role in the mechanism of EMT.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Triple (Participant, Care Provider, Outcomes Assessor)
measure: Boston-test for aphasia diagnosis
time frame: 3 years
description: Evaluates the different domains of language to determine the severity degree of aphasia. Applicable in patients from 16 years old and its duration is approximately 90 minutes. This test has various scales such as intonation, phrase extension, language articulation, grammar, paraphasias, repetition, word search and listening
measure: Zung- Depression and anxiety
time frame: 3 years
description: Evaluates the level of depression in patients with a depressive disorder. This scale is conformed by 20 items assessing 4 common characteristics of depression: the dominant effect, physiological equivalents, other disturbances, and psychomotor activities. Each question is rated on a scale of 1-4 categorized in (1 = few times, 2 = some times, 3 = a good part of the time and 4 = most of the time). The score range is 20-80. Where scores between 5-49 equivalent to a normal range; 50-59 slightly depressed; 60-69 moderately depressed and severely depressed 70 or more [56].
measure: Barthel-Scale
time frame: 3 Years
description: Instrument for measuring the basic activities of daily living (ADL), used especially in patients with acute cerebrovascular disease. Rate the ability of a person to perform in a dependent or independent 10 ABVD, assigning a score (0, 5, 10,15) depending on the time spent on its implementation and the need for help to carry it out. The final score ranges from 0 to 100 where the values are equivalent to between 95-100 independent.; 91-99 mild dependent; 61-90: moderately dependent; 21-60; dependent grave; 0-20 totally dependent [57].
measure: Scale quality of life (EuroQol, EQ-5D)
time frame: 3 Years
description: Evaluate two aspects:The first is the description of the state of health in five dimensions (mobility, self-care, usual activities, pain / discomfort and anxiety / depression), each of which is defined with three levels of severity, as measured by a Likert scale (no problems, some problems and many problems or inability to activity) type. The state of health of the individual is a combination of severity in each five dimensions, expressed by a numerical data. On the other hand, in the second part of the questionnaire the subject must score on a visual millimeter analogue scale his auto perception condition health at the time, considering the ends of the scale as the worst health status (0) and better health [61, 62]
measure: Edinburgh-Scale
time frame: 3 Years
description: Is used to assess handedness in daily activities. This inventory can be scored through observation or patient self-report. Interpretation: scores below -40 correspond to left dominance; scores between -40 and +40 is ambidextrous and above +40 right dominance [55].
measure: Verbal Fluency Test (FAS)
time frame: 3 Years
description: Evaluates the spontaneous production of words under restricted search of verbal fluency association. To evaluate phonological fluency, the patient must produce orally as many words as possible starting with certain letter in a determined period of time, a minute. While for evaluating semantic fluency, will be asked to the patient to name as many animals and fruits as possible in one minute. The score takes into account the total amount of words correctly produced for both categories, and further the number of perseverations, referrals, paraphasias [58] and own names.
measure: Brief Neuropsychological Battery (NEUROPSI)
time frame: 3 Years
description: Provides quantitative and qualitative data. Provides a cognitive profile of the patient and allows individual scores for each area, the cognitive domains assessed are: orientation, attention and concentration, leguaje, memory, executive functions, reading, writing, arithmetic. A gradient of severity of cognitive impairment, with an operating range that includes normal and mild, moderate and severe disorders is obtained. It is based on solid normative data that allow comparison and correction according to age and education.
arm group label: Active Transcranial Magnetic Stimulation TMS- r
arm group type: Active Comparator
description: Application of single stimulation pulses and regularly repeated ones, the frequency may be divided into high frequency EMT (> 1 Hz), low frequency (<1 Hz) This classification is based on physiological effects (stimulation or inhibition neuronal respectively). In this particular case, we will use low frequency <1 Hz with repetitive pulses.
arm group label: Placebo Transcranial Magnetic Stimulation
arm group type: Placebo Comparator
description: Placebo coil that will simulate the sound of the pulses.
intervention type: Device
intervention name: Transcranial Magnetic Stimulation (TMS-r)
description: 10 sessions, each session of EMT-r will be low frequency (1 Hz for 20 minutes and a total of 1200 pulses) using a biphasic pulse stimulator, with active coil (coil-shaped focal or inactive coil "placebo" for 2 weeks from Monday to Friday, target: triangular portion - homologous to injury Inferior front Gyrus (GFI).
arm group label: Active Transcranial Magnetic Stimulation TMS- r
intervention type: Device
intervention name: Placebo Transcranial Magnetic Stimulation
description: 10 sesions of Non- active coil, that will simulate the sound of the TMS, holding the coil on the scalp at an angle of 45 degrees in the selected area
arm group label: Placebo Transcranial Magnetic Stimulation
criteria: 
gender: All
minimum age: 50 Years
maximum age: 70 Years
healthy volunteers: No
last name: Federico A Silva, MD,MSc
role: Principal Investigator
affiliation: Fundacion Cardiovascular de Colombia
last name: Federico A Silva, MD,MSc
phone: 037- 639-9292
phone ext: 255
email: federicosilva@fcv.org
facility: 
status: Recruiting
contact: 
investigator: 
country: Colombia
responsible party type: Sponsor
mesh term: Ischemic Stroke
mesh term: Aphasia
mesh term: Aphasia, Broca