<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02217592</url>
  </required_header>
  <id_info>
    <org_study_id>MICRO1206</org_study_id>
    <secondary_id>1R01HL113382</secondary_id>
    <nct_id>NCT02217592</nct_id>
  </id_info>
  <brief_title>Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast Thailand</brief_title>
  <official_title>Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast (NE) Thailand</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Oxford</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Wellcome Trust</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>National Institutes of Health (NIH)</agency>
      <agency_class>NIH</agency_class>
    </collaborator>
    <collaborator>
      <agency>University of Washington</agency>
      <agency_class>Other</agency_class>
    </collaborator>
    <collaborator>
      <agency>National Heart, Lung, and Blood Institute (NHLBI)</agency>
      <agency_class>NIH</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Oxford</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      This is an observational study to identify the aetiology and factors associated with outcome&#xD;
      of community-acquired sepsis and severe sepsis in Northeast Thailand.&#xD;
&#xD;
      Potential study participants will be adult patients who are presented at the hospital with&#xD;
      community-acquired sepsis. Clinical specimens (including blood, urine, sputum and throat&#xD;
      swabs) will be collected from each participant on admission for culture, PCR and serological&#xD;
      tests, and other laboratory tests, including inflammatory markers and genotyping.&#xD;
      Participants' treatment will be closely monitored during the duration of their hospital stay.&#xD;
      Blood will be again collected at 72 hours after admission. Participants will be contacted at&#xD;
      28 days after admission to determine clinical outcome by phone interview with standardized&#xD;
      script.&#xD;
&#xD;
      There will be a total of 5,020 patients enrolled in this study over 3 years.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Primary objective: To determine the causes of community-acquired sepsis and severe sepsis in&#xD;
      NE Thailand.&#xD;
&#xD;
      Secondary Objectives:&#xD;
&#xD;
        1. To define the clinical outcome of community-acquired sepsis and severe sepsis in NE&#xD;
           Thailand.&#xD;
&#xD;
        2. To determine factors associated with inflammatory response, organ failure, and mortality&#xD;
           in community-acquired sepsis and severe sepsis in NE Thailand, including causes of&#xD;
           sepsis, sepsis resuscitation, antimicrobial treatment and genetic factors.&#xD;
&#xD;
        3. To evaluate diagnostic tests for infection in community-acquired sepsis and severe&#xD;
           sepsis in NE Thailand.&#xD;
&#xD;
      NOTE: THIS STUDY IS CO-SPONSORED BY&#xD;
&#xD;
        1. University of Oxford&#xD;
&#xD;
        2. University of Washington&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date type="Actual">May 20, 2012</start_date>
  <completion_date type="Actual">February 28, 2017</completion_date>
  <primary_completion_date type="Actual">February 28, 2017</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Only</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Percentage of enrolled subjects specified by bacterial/viral infection</measure>
    <time_frame>3 Years</time_frame>
  </primary_outcome>
  <secondary_outcome>
    <measure>Percentage of deaths caused by community-acquired sepsis and severe sepsis in Northeast Thailand</measure>
    <time_frame>3 Years</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Sensitivities and specificities of diagnostic tests for infection in community-acquired sepsis and severe sepsis in Northeast Thailand</measure>
    <time_frame>3 Years</time_frame>
  </secondary_outcome>
  <enrollment type="Actual">5020</enrollment>
  <condition>Sepsis</condition>
  <condition>Severe Sepsis</condition>
  <biospec_retention>Samples With DNA</biospec_retention>
  <biospec_descr>
    <textblock>
      Blood. Urine, pus, sputum, throat swab, and stool (if available)&#xD;
    </textblock>
  </biospec_descr>
  <eligibility>
    <study_pop>
      <textblock>
        Male and female patients, 18 years old with community-acquired sepsis or severe sepsis in&#xD;
        Northeast Thailand&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Males and females 18 years old&#xD;
&#xD;
          -  Thai nationality&#xD;
&#xD;
          -  Required hospitalization as decided by the attending physician&#xD;
&#xD;
          -  Documented by attending physician that an infection is the primary cause of illness&#xD;
             leading to the hospitalization. These can be infections due to any pathogens&#xD;
             (bacteria, viruses, fungi and parasites)&#xD;
&#xD;
          -  Presence of any 3 of the following Systemic Inflammatory Response Syndrome (SIRS)&#xD;
&#xD;
               -  Fever or hypothermia (Core body temperature defined as &gt; 38.3 C or &lt; 36.0 C)&#xD;
&#xD;
               -  Tachycardia (heart rate &gt; 90 beats per minute)&#xD;
&#xD;
               -  Tachypnea (respiratory rate &gt; 20 per minute)&#xD;
&#xD;
               -  Arterial hypotension (systolic blood pressure (SBP) &lt; 90 mmHg, mean arterial&#xD;
                  pressure (MAP) &lt; 70 mmHg, or SBP decrease &gt; 40 mmHg)&#xD;
&#xD;
               -  White blood cell (WBC) &gt; 12,000/µL &lt; 4000/µL or immature forms &gt; 10%&#xD;
&#xD;
               -  Platelet count &lt; 100,000/microlitre&#xD;
&#xD;
               -  Altered mental status with Glasgow Coma Score (GCS) &lt; 15&#xD;
&#xD;
               -  Hypoxemia (Pulse Oximetry Level &lt; 95)&#xD;
&#xD;
               -  Ileus&#xD;
&#xD;
               -  Significant edema or positive fluid balance&#xD;
&#xD;
               -  Decreased capillary refill or mottling&#xD;
&#xD;
               -  Hyperglycemia (plasma glucose &gt; 140 mg/dL) in the absence of diabetes&#xD;
&#xD;
               -  Plasma C-reactive protein &gt; 2 SD above the normal value&#xD;
&#xD;
               -  Plasma procalcitonin &gt; 2 SD above the normal value&#xD;
&#xD;
               -  Arterial hypoxemia (PaO2 / FIO2 &lt; 300)&#xD;
&#xD;
               -  Acute oliguria (urine output &lt; 0.5 mL/kg/hr or 45 mmol/L for 2 hours)&#xD;
&#xD;
               -  Creatinine increase &gt; 0.5 mg/dL&#xD;
&#xD;
               -  INR &gt; 1.5 or aPTT &gt; 60 seconds&#xD;
&#xD;
               -  Plasma total bilirubin &gt; 4 mg/dl or 70 mmol/L&#xD;
&#xD;
               -  Hyperlactatemia (&gt; 1 mmol/L)&#xD;
&#xD;
        Exclusion Criteria&#xD;
&#xD;
          -  Infection is not suspected to be a primary cause of the current illness episode&#xD;
             leading to the hospitalization. For example, community-acquired sepsis or severe&#xD;
             sepsis is considered to be due to stroke, cardiovascular diseases, acute myocardial&#xD;
             infarction, cancer, burn, injury, and trauma&#xD;
&#xD;
          -  Hospitalized at this study site for this current episode for more than 24 hours before&#xD;
             enrollment&#xD;
&#xD;
          -  Hospitalized for this current episode for more than 72 hours at another&#xD;
             primary/referring hospital&#xD;
&#xD;
          -  Prior to this current episode, the patient was admitted to any hospital within the&#xD;
             last 30 days&#xD;
&#xD;
          -  Prior to enrolment, it is documented by the attending physician that hospital acquired&#xD;
             infection is associated with the cause of sepsis or severe sepsis&#xD;
&#xD;
        Please note that the following conditions are not exclusion criteria, and patients with the&#xD;
        following conditions can be enrolled into the study&#xD;
&#xD;
          -  Confirmed diagnosis by any method of an infection as a major cause of illnesses&#xD;
             leading to hospitalization. For example, a patient who already has had a definite&#xD;
             diagnosis of malarial infection by blood smear&#xD;
&#xD;
          -  Clinical diagnosis of any specific disease or any specific syndromes such as acute&#xD;
             infective diarrhea, acute pneumonia, acute encephalomyelitis and acute myocarditis&#xD;
&#xD;
          -  Suspected of having both infectious and non-infectious diseases and infectious disease&#xD;
             is a primary cause of illnesses (primary diagnosis) leading to the hospitalization.&#xD;
             For example, acute pneumonia with stroke as an underlying disease, etc&#xD;
&#xD;
          -  Patients who are admitted to other hospitals and referred to the study site. For&#xD;
             example a referred patient who admit to the first hospital less than 48 hours prior to&#xD;
             enrollment&#xD;
&#xD;
          -  Patients fulfilling the inclusion criteria without having result of complete blood&#xD;
             count or result of all parameters in the inclusion criteria. For example, a patient&#xD;
             who has hypothermia, tachycardia and tachypnea completes the criteria of SIRS even&#xD;
             without the result of complete blood count or the result of other parameters such as&#xD;
             INR, or plasma procalcitonin&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Dr.Direk Limmathurotsakul</last_name>
    <role>Principal Investigator</role>
    <affiliation>Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol university, Thailand</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Sappasithiprasong Hospital</name>
      <address>
        <city>Ubon Ratchathani</city>
        <zip>34000</zip>
        <country>Thailand</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Thailand</country>
  </location_countries>
  <reference>
    <citation>Limmathurotsakul D, Wuthiekanun V, Chantratita N, Wongsuvan G, Amornchai P, Day NP, Peacock SJ. Burkholderia pseudomallei is spatially distributed in soil in northeast Thailand. PLoS Negl Trop Dis. 2010 Jun 1;4(6):e694. doi: 10.1371/journal.pntd.0000694.</citation>
    <PMID>20532233</PMID>
  </reference>
  <reference>
    <citation>Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001 Jul;29(7):1303-10. doi: 10.1097/00003246-200107000-00002.</citation>
    <PMID>11445675</PMID>
  </reference>
  <reference>
    <citation>Cheng AC, West TE, Limmathurotsakul D, Peacock SJ. Strategies to reduce mortality from bacterial sepsis in adults in developing countries. PLoS Med. 2008 Aug 19;5(8):e175. doi: 10.1371/journal.pmed.0050175.</citation>
    <PMID>18752342</PMID>
  </reference>
  <reference>
    <citation>Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM; FEAST Trial Group. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011 Jun 30;364(26):2483-95. doi: 10.1056/NEJMoa1101549. Epub 2011 May 26.</citation>
    <PMID>21615299</PMID>
  </reference>
  <reference>
    <citation>Suttinont C, Losuwanaluk K, Niwatayakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, Suwancharoen D, Panlar P, Saisongkorh W, Rolain JM, Raoult D, Suputtamongkol Y. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Ann Trop Med Parasitol. 2006 Jun;100(4):363-70. doi: 10.1179/136485906X112158.</citation>
    <PMID>16762116</PMID>
  </reference>
  <reference>
    <citation>Gasem MH, Wagenaar JF, Goris MG, Adi MS, Isbandrio BB, Hartskeerl RA, Rolain JM, Raoult D, van Gorp EC. Murine typhus and leptospirosis as causes of acute undifferentiated fever, Indonesia. Emerg Infect Dis. 2009 Jun;15(6):975-7. doi: 10.3201/eid1506.081405.</citation>
    <PMID>19523308</PMID>
  </reference>
  <reference>
    <citation>Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaseum V, Rasachack B, Phiasakha K, Soukkhaseum S, Frichithavong K, Chu V, Keolouangkhot V, Martinez-Aussel B, Chang K, Darasavath C, Rattanavong O, Sisouphone S, Mayxay M, Vidamaly S, Parola P, Thammavong C, Heuangvongsy M, Syhavong B, Raoult D, White NJ, Newton PN. Rickettsial infections and fever, Vientiane, Laos. Emerg Infect Dis. 2006 Feb;12(2):256-62. doi: 10.3201/eid1202.050900.</citation>
    <PMID>16494751</PMID>
  </reference>
  <reference>
    <citation>Wijedoru LP, Kumar V, Chanpheaktra N, Chheng K, Smits HL, Pastoor R, Nga TV, Baker S, Wuthiekanun V, Peacock SJ, Putchhat H, Parry CM. Typhoid fever among hospitalized febrile children in Siem Reap, Cambodia. J Trop Pediatr. 2012 Feb;58(1):68-70. doi: 10.1093/tropej/fmr032. Epub 2011 Apr 20.</citation>
    <PMID>21508082</PMID>
  </reference>
  <reference>
    <citation>Suputtamongkol Y, Hall AJ, Dance DA, Chaowagul W, Rajchanuvong A, Smith MD, White NJ. The epidemiology of melioidosis in Ubon Ratchatani, northeast Thailand. Int J Epidemiol. 1994 Oct;23(5):1082-90. doi: 10.1093/ije/23.5.1082.</citation>
    <PMID>7860160</PMID>
  </reference>
  <reference>
    <citation>Limmathurotsakul D, Wongratanacheewin S, Teerawattanasook N, Wongsuvan G, Chaisuksant S, Chetchotisakd P, Chaowagul W, Day NP, Peacock SJ. Increasing incidence of human melioidosis in Northeast Thailand. Am J Trop Med Hyg. 2010 Jun;82(6):1113-7. doi: 10.4269/ajtmh.2010.10-0038.</citation>
    <PMID>20519609</PMID>
  </reference>
  <reference>
    <citation>Fowler VG Jr, Olsen MK, Corey GR, Woods CW, Cabell CH, Reller LB, Cheng AC, Dudley T, Oddone EZ. Clinical identifiers of complicated Staphylococcus aureus bacteremia. Arch Intern Med. 2003 Sep 22;163(17):2066-72. doi: 10.1001/archinte.163.17.2066.</citation>
    <PMID>14504120</PMID>
  </reference>
  <reference>
    <citation>West TE, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Myers ND, Emond MJ, Wurfel MM, Hawn TR, Peacock SJ, Skerrett SJ. Impaired TLR5 functionality is associated with survival in melioidosis. J Immunol. 2013 Apr 1;190(7):3373-9. doi: 10.4049/jimmunol.1202974. Epub 2013 Feb 27.</citation>
    <PMID>23447684</PMID>
  </reference>
  <verification_date>October 2017</verification_date>
  <study_first_submitted>August 1, 2014</study_first_submitted>
  <study_first_submitted_qc>August 13, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">August 15, 2014</study_first_posted>
  <last_update_submitted>October 30, 2017</last_update_submitted>
  <last_update_submitted_qc>October 30, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">November 1, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Sepsis</mesh_term>
    <mesh_term>Toxemia</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02217592
org study id: MICRO1206
secondary id: 1R01HL113382
nct id: NCT02217592
lead sponsor: 
collaborator: 
collaborator: 
collaborator: 
collaborator: 
has dmc: No
This is an observational study to identify the aetiology and factors associated with outcome
      of community-acquired sepsis and severe sepsis in Northeast Thailand.

      Potential study participants will be adult patients who are presented at the hospital with
      community-acquired sepsis. Clinical specimens (including blood, urine, sputum and throat
      swabs) will be collected from each participant on admission for culture, PCR and serological
      tests, and other laboratory tests, including inflammatory markers and genotyping.
      Participants' treatment will be closely monitored during the duration of their hospital stay.
      Blood will be again collected at 72 hours after admission. Participants will be contacted at
      28 days after admission to determine clinical outcome by phone interview with standardized
      script.

      There will be a total of 5,020 patients enrolled in this study over 3 years.
Primary objective: To determine the causes of community-acquired sepsis and severe sepsis in
      NE Thailand.

      Secondary Objectives:

        1. To define the clinical outcome of community-acquired sepsis and severe sepsis in NE
           Thailand.

        2. To determine factors associated with inflammatory response, organ failure, and mortality
           in community-acquired sepsis and severe sepsis in NE Thailand, including causes of
           sepsis, sepsis resuscitation, antimicrobial treatment and genetic factors.

        3. To evaluate diagnostic tests for infection in community-acquired sepsis and severe
           sepsis in NE Thailand.

      NOTE: THIS STUDY IS CO-SPONSORED BY

        1. University of Oxford

        2. University of Washington
observational model: Case-Only
time perspective: Prospective
measure: Percentage of enrolled subjects specified by bacterial/viral infection
time frame: 3 Years
measure: Percentage of deaths caused by community-acquired sepsis and severe sepsis in Northeast Thailand
time frame: 3 Years
measure: Sensitivities and specificities of diagnostic tests for infection in community-acquired sepsis and severe sepsis in Northeast Thailand
time frame: 3 Years
Blood. Urine, pus, sputum, throat swab, and stool (if available)
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Dr.Direk Limmathurotsakul
role: Principal Investigator
affiliation: Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol university, Thailand
facility: 
country: Thailand
citation: Limmathurotsakul D, Wuthiekanun V, Chantratita N, Wongsuvan G, Amornchai P, Day NP, Peacock SJ. Burkholderia pseudomallei is spatially distributed in soil in northeast Thailand. PLoS Negl Trop Dis. 2010 Jun 1;4(6):e694. doi: 10.1371/journal.pntd.0000694.
PMID: 20532233
citation: Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001 Jul;29(7):1303-10. doi: 10.1097/00003246-200107000-00002.
PMID: 11445675
citation: Cheng AC, West TE, Limmathurotsakul D, Peacock SJ. Strategies to reduce mortality from bacterial sepsis in adults in developing countries. PLoS Med. 2008 Aug 19;5(8):e175. doi: 10.1371/journal.pmed.0050175.
PMID: 18752342
citation: Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T, Brent B, Evans JA, Tibenderana JK, Crawley J, Russell EC, Levin M, Babiker AG, Gibb DM; FEAST Trial Group. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011 Jun 30;364(26):2483-95. doi: 10.1056/NEJMoa1101549. Epub 2011 May 26.
PMID: 21615299
citation: Suttinont C, Losuwanaluk K, Niwatayakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, Suwancharoen D, Panlar P, Saisongkorh W, Rolain JM, Raoult D, Suputtamongkol Y. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Ann Trop Med Parasitol. 2006 Jun;100(4):363-70. doi: 10.1179/136485906X112158.
PMID: 16762116
citation: Gasem MH, Wagenaar JF, Goris MG, Adi MS, Isbandrio BB, Hartskeerl RA, Rolain JM, Raoult D, van Gorp EC. Murine typhus and leptospirosis as causes of acute undifferentiated fever, Indonesia. Emerg Infect Dis. 2009 Jun;15(6):975-7. doi: 10.3201/eid1506.081405.
PMID: 19523308
citation: Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaseum V, Rasachack B, Phiasakha K, Soukkhaseum S, Frichithavong K, Chu V, Keolouangkhot V, Martinez-Aussel B, Chang K, Darasavath C, Rattanavong O, Sisouphone S, Mayxay M, Vidamaly S, Parola P, Thammavong C, Heuangvongsy M, Syhavong B, Raoult D, White NJ, Newton PN. Rickettsial infections and fever, Vientiane, Laos. Emerg Infect Dis. 2006 Feb;12(2):256-62. doi: 10.3201/eid1202.050900.
PMID: 16494751
citation: Wijedoru LP, Kumar V, Chanpheaktra N, Chheng K, Smits HL, Pastoor R, Nga TV, Baker S, Wuthiekanun V, Peacock SJ, Putchhat H, Parry CM. Typhoid fever among hospitalized febrile children in Siem Reap, Cambodia. J Trop Pediatr. 2012 Feb;58(1):68-70. doi: 10.1093/tropej/fmr032. Epub 2011 Apr 20.
PMID: 21508082
citation: Suputtamongkol Y, Hall AJ, Dance DA, Chaowagul W, Rajchanuvong A, Smith MD, White NJ. The epidemiology of melioidosis in Ubon Ratchatani, northeast Thailand. Int J Epidemiol. 1994 Oct;23(5):1082-90. doi: 10.1093/ije/23.5.1082.
PMID: 7860160
citation: Limmathurotsakul D, Wongratanacheewin S, Teerawattanasook N, Wongsuvan G, Chaisuksant S, Chetchotisakd P, Chaowagul W, Day NP, Peacock SJ. Increasing incidence of human melioidosis in Northeast Thailand. Am J Trop Med Hyg. 2010 Jun;82(6):1113-7. doi: 10.4269/ajtmh.2010.10-0038.
PMID: 20519609
citation: Fowler VG Jr, Olsen MK, Corey GR, Woods CW, Cabell CH, Reller LB, Cheng AC, Dudley T, Oddone EZ. Clinical identifiers of complicated Staphylococcus aureus bacteremia. Arch Intern Med. 2003 Sep 22;163(17):2066-72. doi: 10.1001/archinte.163.17.2066.
PMID: 14504120
citation: West TE, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Myers ND, Emond MJ, Wurfel MM, Hawn TR, Peacock SJ, Skerrett SJ. Impaired TLR5 functionality is associated with survival in melioidosis. J Immunol. 2013 Apr 1;190(7):3373-9. doi: 10.4049/jimmunol.1202974. Epub 2013 Feb 27.
PMID: 23447684
responsible party type: Sponsor
mesh term: Sepsis
mesh term: Toxemia