<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02253251</url>
  </required_header>
  <id_info>
    <org_study_id>Pro00009633</org_study_id>
    <nct_id>NCT02253251</nct_id>
  </id_info>
  <brief_title>Clinical Validation of the Role of microRNA Binding Site Mutations in Cancer Risk, Prevention and Treatment</brief_title>
  <official_title>Clinical Validation of the Role of microRNA Binding Site Mutations in Cancer Risk, Prevention and Treatment</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>MiraKind</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>MiraKind</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The investigators will recruit and enroll individuals that may have the KRAS-variant or other&#xD;
      microRNA binding site mutations to join registry studies. The investigators will allow&#xD;
      individuals to obtain their results through a physician at the completion of the studies. The&#xD;
      investigators current focus is cancer and autoimmunity.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The investigators have identified germ-line microRNA binding site mutations that predict an&#xD;
      increased risk of cancer, endometriosis and associated infertility, and unique tumor biology&#xD;
      and response to treatment. The goal of this protocol is to further determine the mechanisms&#xD;
      of these mutations, such as the KRAS-variant, and their associations with human health, such&#xD;
      as cancer. The investigators will collect saliva samples from individual patients who are&#xD;
      eligible and choose to enroll in these studies, to test for the KRAS-variant and/or other&#xD;
      mutations under study. With specific permission, the investigators will keep excess DNA to&#xD;
      further investigate and discover additional similar mutations. The investigators purpose is&#xD;
      to have participants answer questionnaires about lifestyle factors in an ongoing manner, to&#xD;
      understand the impact of different factors on cancer risk for patients with these mutations.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Recruiting</overall_status>
  <start_date>September 2014</start_date>
  <completion_date type="Anticipated">September 2025</completion_date>
  <primary_completion_date type="Anticipated">September 2025</primary_completion_date>
  <study_type>Observational [Patient Registry]</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Cohort</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <target_duration>10 Years</target_duration>
  <primary_outcome>
    <measure>Measuring the prevalence of the KRAS-variant in certain populations Prevalence of the KRAS-variant in BRCA negative breast cancer patients</measure>
    <time_frame>1 year</time_frame>
    <description>The Prevalence of the KRAS-variant will be determined in specific populations, such as women with drug resistant endometriosis, or BRCA negative breast cancer. The prevalence will be compared to extensive data on the expected and known prevalence of the KRAS-variant in non-diseased populations. Statistical significance will be determined by Chi-squared analysis.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Comparing the impact of interventions in KRAS-variant versus non-KRAS variant populations</measure>
    <time_frame>1 year</time_frame>
    <description>We will compare the impact of specific treatment approaches for example in women with the KRAS-variant and double primary breast cancer, versus the interventions used in non-KRAS-variant double primary breast cancer patients.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>The impact of lifestyle factors on cancer risk for KRAS-variant patients</measure>
    <time_frame>10 years</time_frame>
    <description>Individuals with the KRAS-variant will be prospectively followed, and lifestyle factors will be associated with changes in health, including cancer development. Our goal is to compare baseline characteristics between individuals with the KRAS-variant who do, versus do not, develop cancer, for example.</description>
  </secondary_outcome>
  <number_of_groups>4</number_of_groups>
  <enrollment type="Anticipated">15000</enrollment>
  <condition>Cancer</condition>
  <arm_group>
    <arm_group_label>Family Registry</arm_group_label>
    <description>For individuals identified with the KRAS-variant. Patients will be prospectively followed to determine the impact of lifestyle on disease risk.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>KRAS-variant BRCA negative Breast Cancer</arm_group_label>
    <description>Women with breast cancer who are BRCA negative will be tested for the KRAS-variant, to determine the associations as well as the prevalence.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Double primary breast cancer</arm_group_label>
    <description>Women with multiple primary breast cancer will be tested for the KRAS-variant and compared between those with this mutation and those without.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Autoimmunity</arm_group_label>
    <description>We have shown that the KRAS-variant and other members of this genetic class of mutations associate with altered immunity, leading to immunosuppression as well as autoimmunity.</description>
  </arm_group>
  <intervention>
    <intervention_type>Genetic</intervention_type>
    <intervention_name>KRAS-variant and microRNA binding site mutation testing</intervention_name>
    <description>Participant in these studies will be tested for the KRAS-variant</description>
    <arm_group_label>Double primary breast cancer</arm_group_label>
    <arm_group_label>Family Registry</arm_group_label>
    <arm_group_label>KRAS-variant BRCA negative Breast Cancer</arm_group_label>
  </intervention>
  <biospec_retention>Samples Without DNA</biospec_retention>
  <biospec_descr>
    <textblock>
      DNA will be isolated from the submitted sample and kept with permission for additional&#xD;
      studies.&#xD;
    </textblock>
  </biospec_descr>
  <eligibility>
    <study_pop>
      <textblock>
        Breast and ovarian cancer patients and the family members of those that have the&#xD;
        KRAS-variant from primarily the US. Those with Autoimmunity.&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Personal or family history of cancer&#xD;
&#xD;
          -  Personal history of endometriosis, or autoimmunity&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Younger than 18&#xD;
&#xD;
          -  Non-english speaking and unable to understand and sign the consent&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Joanne Weidhaas, MDPhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>MiraKind</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Joanne Weidhaas, MDPhD</last_name>
    <phone>203-671-1308</phone>
    <email>joanne@mirakind.org</email>
  </overall_contact>
  <overall_contact_backup>
    <last_name>Joanne Weidhaas</last_name>
    <phone>424-387-8100</phone>
    <email>Joanne@miradx.com</email>
  </overall_contact_backup>
  <location>
    <facility>
      <name>MiraKind</name>
      <address>
        <city>Los Angeles</city>
        <state>California</state>
        <zip>90025</zip>
        <country>United States</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Joanne Weidhaas, MDPhD</last_name>
      <phone>203-671-1308</phone>
      <email>joanne@mirakind.org</email>
    </contact>
    <contact_backup>
      <last_name>Joanne Weidhaas</last_name>
      <phone>424-387-8100</phone>
    </contact_backup>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <link>
    <url>http://mirakind.org</url>
    <description>non-profit running the study</description>
  </link>
  <reference>
    <citation>Saridaki Z, Weidhaas JB, Lenz HJ, Laurent-Puig P, Jacobs B, De Schutter J, De Roock W, Salzman DW, Zhang W, Yang D, Pilati C, Bouche O, Piessevaux H, Tejpar S. A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy. Clin Cancer Res. 2014 Sep 1;20(17):4499-4510. doi: 10.1158/1078-0432.CCR-14-0348.</citation>
    <PMID>25183481</PMID>
  </reference>
  <reference>
    <citation>Chung CH, Lee JW, Slebos RJ, Howard JD, Perez J, Kang H, Fertig EJ, Considine M, Gilbert J, Murphy BA, Nallur S, Paranjape T, Jordan RC, Garcia J, Burtness B, Forastiere AA, Weidhaas JB. A 3'-UTR KRAS-variant is associated with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol. 2014 Nov;25(11):2230-2236. doi: 10.1093/annonc/mdu367. Epub 2014 Jul 31. Erratum In: Ann Oncol. 2015 May;26(5):1038-9.</citation>
    <PMID>25081901</PMID>
  </reference>
  <reference>
    <citation>Pilarski R, Patel DA, Weitzel J, McVeigh T, Dorairaj JJ, Heneghan HM, Miller N, Weidhaas JB, Kerin MJ, McKenna M, Wu X, Hildebrandt M, Zelterman D, Sand S, Shulman LP. The KRAS-variant is associated with risk of developing double primary breast and ovarian cancer. PLoS One. 2012;7(5):e37891. doi: 10.1371/journal.pone.0037891. Epub 2012 May 25.</citation>
    <PMID>22662244</PMID>
  </reference>
  <reference>
    <citation>Grechukhina O, Petracco R, Popkhadze S, Massasa E, Paranjape T, Chan E, Flores I, Weidhaas JB, Taylor HS. A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis. EMBO Mol Med. 2012 Mar;4(3):206-17. doi: 10.1002/emmm.201100200. Epub 2012 Feb 3.</citation>
    <PMID>22307873</PMID>
  </reference>
  <reference>
    <citation>Ratner ES, Keane FK, Lindner R, Tassi RA, Paranjape T, Glasgow M, Nallur S, Deng Y, Lu L, Steele L, Sand S, Muller RU, Bignotti E, Bellone S, Boeke M, Yao X, Pecorelli S, Ravaggi A, Katsaros D, Zelterman D, Cristea MC, Yu H, Rutherford TJ, Weitzel JN, Neuhausen SL, Schwartz PE, Slack FJ, Santin AD, Weidhaas JB. A KRAS variant is a biomarker of poor outcome, platinum chemotherapy resistance and a potential target for therapy in ovarian cancer. Oncogene. 2012 Oct 18;31(42):4559-66. doi: 10.1038/onc.2011.539. Epub 2011 Dec 5.</citation>
    <PMID>22139083</PMID>
  </reference>
  <reference>
    <citation>Lee LJ, Ratner E, Uduman M, Winter K, Boeke M, Greven KM, King S, Burke TW, Underhill K, Kim H, Boulware RJ, Yu H, Parkash V, Lu L, Gaffney D, Dicker AP, Weidhaas J. The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905. PLoS One. 2014 Apr 14;9(4):e94167. doi: 10.1371/journal.pone.0094167. eCollection 2014.</citation>
    <PMID>24732316</PMID>
  </reference>
  <reference>
    <citation>Smits KM, Paranjape T, Nallur S, Wouters KA, Weijenberg MP, Schouten LJ, van den Brandt PA, Bosman FT, Weidhaas JB, van Engeland M. A let-7 microRNA SNP in the KRAS 3'UTR is prognostic in early-stage colorectal cancer. Clin Cancer Res. 2011 Dec 15;17(24):7723-31. doi: 10.1158/1078-0432.CCR-11-0990. Epub 2011 Oct 12.</citation>
    <PMID>21994416</PMID>
  </reference>
  <reference>
    <citation>Paranjape T, Heneghan H, Lindner R, Keane FK, Hoffman A, Hollestelle A, Dorairaj J, Geyda K, Pelletier C, Nallur S, Martens JW, Hooning MJ, Kerin M, Zelterman D, Zhu Y, Tuck D, Harris L, Miller N, Slack F, Weidhaas J. A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis. Lancet Oncol. 2011 Apr;12(4):377-86. doi: 10.1016/S1470-2045(11)70044-4. Epub 2011 Mar 22. Erratum In: Lancet Oncol. 2011 Jun;12(6):522.</citation>
    <PMID>21435948</PMID>
  </reference>
  <reference>
    <citation>Hollestelle A, Pelletier C, Hooning M, Crepin E, Schutte M, Look M, Collee JM, Nieuwlaat A, Dorssers LC, Seynaeve C, Aulchenko YS, Martens JW, van den Ouweland AM, Weidhaas JB. Prevalence of the variant allele rs61764370 T&gt;G in the 3'UTR of KRAS among Dutch BRCA1, BRCA2 and non-BRCA1/BRCA2 breast cancer families. Breast Cancer Res Treat. 2011 Jul;128(1):79-84. doi: 10.1007/s10549-010-1080-z. Epub 2010 Jul 30.</citation>
    <PMID>20676756</PMID>
  </reference>
  <reference>
    <citation>Ratner E, Lu L, Boeke M, Barnett R, Nallur S, Chin LJ, Pelletier C, Blitzblau R, Tassi R, Paranjape T, Hui P, Godwin AK, Yu H, Risch H, Rutherford T, Schwartz P, Santin A, Matloff E, Zelterman D, Slack FJ, Weidhaas JB. A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk. Cancer Res. 2010 Aug 15;70(16):6509-15. doi: 10.1158/0008-5472.CAN-10-0689. Epub 2010 Jul 20.</citation>
    <PMID>20647319</PMID>
  </reference>
  <reference>
    <citation>Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008 Oct 15;68(20):8535-40. doi: 10.1158/0008-5472.CAN-08-2129.</citation>
    <PMID>18922928</PMID>
  </reference>
  <verification_date>August 2023</verification_date>
  <study_first_submitted>September 25, 2014</study_first_submitted>
  <study_first_submitted_qc>September 26, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">October 1, 2014</study_first_posted>
  <last_update_submitted>August 27, 2023</last_update_submitted>
  <last_update_submitted_qc>August 27, 2023</last_update_submitted_qc>
  <last_update_posted type="Actual">August 29, 2023</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Breast Cancer</keyword>
  <keyword>Cancer Risk</keyword>
  <keyword>Family Breast and Ovarian Cancer</keyword>
  <keyword>Genetic Cancer Risk</keyword>
  <keyword>Cancer Treatment</keyword>
  <keyword>Familial multiple primary cancer risk</keyword>
  <keyword>Autoimmunity</keyword>
  <keyword>Endometriosis</keyword>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02253251
org study id: Pro00009633
nct id: NCT02253251
lead sponsor: 
has dmc: Yes
The investigators will recruit and enroll individuals that may have the KRAS-variant or other
      microRNA binding site mutations to join registry studies. The investigators will allow
      individuals to obtain their results through a physician at the completion of the studies. The
      investigators current focus is cancer and autoimmunity.
The investigators have identified germ-line microRNA binding site mutations that predict an
      increased risk of cancer, endometriosis and associated infertility, and unique tumor biology
      and response to treatment. The goal of this protocol is to further determine the mechanisms
      of these mutations, such as the KRAS-variant, and their associations with human health, such
      as cancer. The investigators will collect saliva samples from individual patients who are
      eligible and choose to enroll in these studies, to test for the KRAS-variant and/or other
      mutations under study. With specific permission, the investigators will keep excess DNA to
      further investigate and discover additional similar mutations. The investigators purpose is
      to have participants answer questionnaires about lifestyle factors in an ongoing manner, to
      understand the impact of different factors on cancer risk for patients with these mutations.
observational model: Cohort
time perspective: Prospective
measure: Measuring the prevalence of the KRAS-variant in certain populations Prevalence of the KRAS-variant in BRCA negative breast cancer patients
time frame: 1 year
description: The Prevalence of the KRAS-variant will be determined in specific populations, such as women with drug resistant endometriosis, or BRCA negative breast cancer. The prevalence will be compared to extensive data on the expected and known prevalence of the KRAS-variant in non-diseased populations. Statistical significance will be determined by Chi-squared analysis.
measure: Comparing the impact of interventions in KRAS-variant versus non-KRAS variant populations
time frame: 1 year
description: We will compare the impact of specific treatment approaches for example in women with the KRAS-variant and double primary breast cancer, versus the interventions used in non-KRAS-variant double primary breast cancer patients.
measure: The impact of lifestyle factors on cancer risk for KRAS-variant patients
time frame: 10 years
description: Individuals with the KRAS-variant will be prospectively followed, and lifestyle factors will be associated with changes in health, including cancer development. Our goal is to compare baseline characteristics between individuals with the KRAS-variant who do, versus do not, develop cancer, for example.
arm group label: Family Registry
description: For individuals identified with the KRAS-variant. Patients will be prospectively followed to determine the impact of lifestyle on disease risk.
arm group label: KRAS-variant BRCA negative Breast Cancer
description: Women with breast cancer who are BRCA negative will be tested for the KRAS-variant, to determine the associations as well as the prevalence.
arm group label: Double primary breast cancer
description: Women with multiple primary breast cancer will be tested for the KRAS-variant and compared between those with this mutation and those without.
arm group label: Autoimmunity
description: We have shown that the KRAS-variant and other members of this genetic class of mutations associate with altered immunity, leading to immunosuppression as well as autoimmunity.
intervention type: Genetic
intervention name: KRAS-variant and microRNA binding site mutation testing
description: Participant in these studies will be tested for the KRAS-variant
arm group label: Double primary breast cancer
arm group label: Family Registry
arm group label: KRAS-variant BRCA negative Breast Cancer
DNA will be isolated from the submitted sample and kept with permission for additional
      studies.
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
last name: Joanne Weidhaas, MDPhD
role: Principal Investigator
affiliation: MiraKind
last name: Joanne Weidhaas, MDPhD
phone: 203-671-1308
email: joanne@mirakind.org
last name: Joanne Weidhaas
phone: 424-387-8100
email: Joanne@miradx.com
facility: 
status: Recruiting
contact: 
contact backup: 
country: United States
url: http://mirakind.org
description: non-profit running the study
citation: Saridaki Z, Weidhaas JB, Lenz HJ, Laurent-Puig P, Jacobs B, De Schutter J, De Roock W, Salzman DW, Zhang W, Yang D, Pilati C, Bouche O, Piessevaux H, Tejpar S. A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in patients with metastatic colorectal cancer treated with salvage cetuximab/panitumumab monotherapy. Clin Cancer Res. 2014 Sep 1;20(17):4499-4510. doi: 10.1158/1078-0432.CCR-14-0348.
PMID: 25183481
citation: Chung CH, Lee JW, Slebos RJ, Howard JD, Perez J, Kang H, Fertig EJ, Considine M, Gilbert J, Murphy BA, Nallur S, Paranjape T, Jordan RC, Garcia J, Burtness B, Forastiere AA, Weidhaas JB. A 3'-UTR KRAS-variant is associated with cisplatin resistance in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol. 2014 Nov;25(11):2230-2236. doi: 10.1093/annonc/mdu367. Epub 2014 Jul 31. Erratum In: Ann Oncol. 2015 May;26(5):1038-9.
PMID: 25081901
citation: Pilarski R, Patel DA, Weitzel J, McVeigh T, Dorairaj JJ, Heneghan HM, Miller N, Weidhaas JB, Kerin MJ, McKenna M, Wu X, Hildebrandt M, Zelterman D, Sand S, Shulman LP. The KRAS-variant is associated with risk of developing double primary breast and ovarian cancer. PLoS One. 2012;7(5):e37891. doi: 10.1371/journal.pone.0037891. Epub 2012 May 25.
PMID: 22662244
citation: Grechukhina O, Petracco R, Popkhadze S, Massasa E, Paranjape T, Chan E, Flores I, Weidhaas JB, Taylor HS. A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis. EMBO Mol Med. 2012 Mar;4(3):206-17. doi: 10.1002/emmm.201100200. Epub 2012 Feb 3.
PMID: 22307873
citation: Ratner ES, Keane FK, Lindner R, Tassi RA, Paranjape T, Glasgow M, Nallur S, Deng Y, Lu L, Steele L, Sand S, Muller RU, Bignotti E, Bellone S, Boeke M, Yao X, Pecorelli S, Ravaggi A, Katsaros D, Zelterman D, Cristea MC, Yu H, Rutherford TJ, Weitzel JN, Neuhausen SL, Schwartz PE, Slack FJ, Santin AD, Weidhaas JB. A KRAS variant is a biomarker of poor outcome, platinum chemotherapy resistance and a potential target for therapy in ovarian cancer. Oncogene. 2012 Oct 18;31(42):4559-66. doi: 10.1038/onc.2011.539. Epub 2011 Dec 5.
PMID: 22139083
citation: Lee LJ, Ratner E, Uduman M, Winter K, Boeke M, Greven KM, King S, Burke TW, Underhill K, Kim H, Boulware RJ, Yu H, Parkash V, Lu L, Gaffney D, Dicker AP, Weidhaas J. The KRAS-variant and miRNA expression in RTOG endometrial cancer clinical trials 9708 and 9905. PLoS One. 2014 Apr 14;9(4):e94167. doi: 10.1371/journal.pone.0094167. eCollection 2014.
PMID: 24732316
citation: Smits KM, Paranjape T, Nallur S, Wouters KA, Weijenberg MP, Schouten LJ, van den Brandt PA, Bosman FT, Weidhaas JB, van Engeland M. A let-7 microRNA SNP in the KRAS 3'UTR is prognostic in early-stage colorectal cancer. Clin Cancer Res. 2011 Dec 15;17(24):7723-31. doi: 10.1158/1078-0432.CCR-11-0990. Epub 2011 Oct 12.
PMID: 21994416
citation: Paranjape T, Heneghan H, Lindner R, Keane FK, Hoffman A, Hollestelle A, Dorairaj J, Geyda K, Pelletier C, Nallur S, Martens JW, Hooning MJ, Kerin M, Zelterman D, Zhu Y, Tuck D, Harris L, Miller N, Slack F, Weidhaas J. A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis. Lancet Oncol. 2011 Apr;12(4):377-86. doi: 10.1016/S1470-2045(11)70044-4. Epub 2011 Mar 22. Erratum In: Lancet Oncol. 2011 Jun;12(6):522.
PMID: 21435948
citation: Hollestelle A, Pelletier C, Hooning M, Crepin E, Schutte M, Look M, Collee JM, Nieuwlaat A, Dorssers LC, Seynaeve C, Aulchenko YS, Martens JW, van den Ouweland AM, Weidhaas JB. Prevalence of the variant allele rs61764370 T>G in the 3'UTR of KRAS among Dutch BRCA1, BRCA2 and non-BRCA1/BRCA2 breast cancer families. Breast Cancer Res Treat. 2011 Jul;128(1):79-84. doi: 10.1007/s10549-010-1080-z. Epub 2010 Jul 30.
PMID: 20676756
citation: Ratner E, Lu L, Boeke M, Barnett R, Nallur S, Chin LJ, Pelletier C, Blitzblau R, Tassi R, Paranjape T, Hui P, Godwin AK, Yu H, Risch H, Rutherford T, Schwartz P, Santin A, Matloff E, Zelterman D, Slack FJ, Weidhaas JB. A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk. Cancer Res. 2010 Aug 15;70(16):6509-15. doi: 10.1158/0008-5472.CAN-10-0689. Epub 2010 Jul 20.
PMID: 20647319
citation: Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB. A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008 Oct 15;68(20):8535-40. doi: 10.1158/0008-5472.CAN-08-2129.
PMID: 18922928
responsible party type: Sponsor