<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02246088</url>
  </required_header>
  <id_info>
    <org_study_id>EDUART13</org_study_id>
    <nct_id>NCT02246088</nct_id>
  </id_info>
  <brief_title>Neuroscience Education on Osteoarthritis</brief_title>
  <official_title>Effect of Neuroscience Education on Subjects With Chronic Knee Pain Related to Osteoarthritis : a Randomized Controlled Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University of Valencia</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>Hospital de la Ribera</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Valencia</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great&#xD;
      disability and significant healthcare costs. Substantial scientific evidence indicates a role&#xD;
      for central sensitization in OA pain. Reconceptualization of pain through Neuroscience&#xD;
      Education (NE) is an intervention that has already been used successfully in some chronic&#xD;
      musculoskeletal pain conditions characterized by alteration on CNS pain processing or central&#xD;
      sensitization (i.e. chronic low back pain, chronic fatigue syndrome, widespread pain and&#xD;
      chronic whiplash associate disorders).There is compelling evidence that NE have a positive&#xD;
      effect on pain, disability, catastrophization and physical performance for chronic&#xD;
      musculoskeletal pain disorders, yet studies examining the value of NE for OA patients are&#xD;
      essentially lacking.&#xD;
&#xD;
      The primary aim of this study is to assess the effect of NE on pain, disability and physical&#xD;
      performance in subjects with chronic OA knee pain waiting for replacement surgery. This will&#xD;
      be the first time NE will be addressed specifically to OA pain. To investigate the benefits&#xD;
      of NE on pain related to knee OA, the effect of a manual therapy intervention combined with&#xD;
      NE (MT+NE) will be compared with this same manual intervention plus an educational program&#xD;
      based on a traditional patho-anatomical or biomedical model (MT+E). The following secondary&#xD;
      aims will be addressed as well:&#xD;
&#xD;
        -  Examining the effects of the two interventions on the mechanism of central sensitization&#xD;
           in patients with knee OA;&#xD;
&#xD;
        -  Examining the effects of the two interventions on pain catastrophizing, illness&#xD;
           perceptions and kinesiophobia in patients with knee OA;&#xD;
&#xD;
        -  Finally, it is aimed at identifying effect moderators for NE in patients with knee OA.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great&#xD;
      disability and significant healthcare costs. Substantial scientific evidence indicates a role&#xD;
      for central sensitization in OA pain. Pathophysiological mechanisms underlying central&#xD;
      sensitisation are complex and numerous, but the net effect is an amplification of neural&#xD;
      signaling within the CNS than elicits pain hypersensitivity. Central sensitization management&#xD;
      is an area of great interest at least in a subgroup of patients with OA pain.&#xD;
&#xD;
      Reconceptualization of pain through Neuroscience Education (NE) is an intervention that has&#xD;
      already been used successfully in some chronic musculoskeletal pain conditions characterized&#xD;
      by alteration on CNS pain processing or central sensitization (i.e. chronic low back pain,&#xD;
      chronic fatigue syndrome, widespread pain and chronic whiplash associate disorders).&#xD;
      Moreover, some clinical guides to help clinicians to identify and explain central&#xD;
      sensitization through NE, have been recently published. However, this kind of intervention&#xD;
      has never been tested specifically for chronic pain related to OA.&#xD;
&#xD;
      Preoperative education centered on a biomedical model of anatomy and pathoanatomy as well as&#xD;
      procedural information has limited effect in reducing postoperative pain after total hip&#xD;
      arthroplasty and total hip arthroplasty surgeries. Preoperative educational sessions that aim&#xD;
      to increase patient knowledge of pain science (i.e. NE) may be more effective in managing&#xD;
      postoperative pain. NE is a cognitive-based educational intervention that aims to reduce pain&#xD;
      and disability by helping patients gain an increased understanding of the biological&#xD;
      processes underpinning their pain state. There is compelling evidence that NE have a positive&#xD;
      effect on pain, disability, catastrophization and physical performance for chronic&#xD;
      musculoskeletal pain disorders, yet studies examining the value of NE for OA patients are&#xD;
      essentially lacking.&#xD;
&#xD;
      Joint mobilization has been shown to be a useful modality to reduce pain related to&#xD;
      osteoarthritis. Regarding the knee joint, two recent systematic reviews demonstrated the&#xD;
      usefulness of manual therapy and exercise for the management of knee OA. Moreover, Deyle et&#xD;
      al reported a preliminary clinical prediction rule which may help to identify the minority of&#xD;
      knee OA patients who are unlikely to respond to this management approach.&#xD;
&#xD;
      The primary aim of this study is therefore to assess the effect of NE on pain, disability and&#xD;
      physical performance in subjects with chronic OA knee pain waiting for replacement surgery.&#xD;
      This will be the first time NE will be addressed specifically to OA pain. To investigate the&#xD;
      benefits of NE on pain related to knee OA, the effect of a manual therapy intervention&#xD;
      combined with NE (MT+NE) will be compared with this same manual intervention plus an&#xD;
      educational program based on a traditional patho-anatomical or biomedical model (MT+E). The&#xD;
      following secondary aims will be addressed as well:&#xD;
&#xD;
        -  Examining the effects of the two interventions on the mechanism of central sensitization&#xD;
           in patients with knee OA;&#xD;
&#xD;
        -  Examining the effects of the two interventions on pain catastrophizing, illness&#xD;
           perceptions and kinesiophobia in patients with knee OA;&#xD;
&#xD;
        -  Finally, it is aimed at identifying effect moderators for NE in patients with knee OA.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date>December 2013</start_date>
  <completion_date type="Anticipated">December 2015</completion_date>
  <primary_completion_date type="Anticipated">December 2015</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Endogenous analgesia through the experimental protocol of conditioned pain modulation</measure>
    <time_frame>Up to 3 months</time_frame>
    <description>For assessing endogenous analgesia, the method examining the influence of the Diffuse Noxious Inhibitory Control system (or spatial summation) on temporal summation will be applied. Recently, the term conditioned pain modulation has been recommended to describe the psychophysical paradigm of Diffuse Noxious Inhibitory Control system in humans</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Pain at rest and in the last 24 hours</measure>
    <time_frame>Up to 3 months</time_frame>
    <description>Participants will be asked to rate their pain at rest and in the last 24 hours on a horizontal 100-mm visual analogue scale (VAS). The horizontal line anchors will be &quot;no pain&quot; and &quot;worst imaginable pain&quot;. The VAS is a valid and reliable instrument compared with other pain rating scales and has been well established in clinical practice and research for measuring pain levels in arthritis populations.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pressure Pain Thresholds</measure>
    <time_frame>Up to 3 months</time_frame>
    <description>Local and distant sites will be chosen for pressure pain threshold measurement. Regarding local sites, two points will be measured from the knee, 3 cm medial and lateral to the midpoint of the medial and lateral edge of patella, respectively. Regarding control site, a distant site will be used to assess systematic analgesic effect of NE at 5 cm distal to lateral epicondyle.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Western Ontario and McMaster osteoarthritis index (WOMAC scale)</measure>
    <time_frame>Up to 3 months</time_frame>
    <description>WOMAC assesses pain, stiffness and physical function and can be completed in less than 5 minutes. It's a widely used, reliable, valid and responsive measure of outcome in people with osteoarthritis of the hip or knee.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Health-related quality of life using the self-reported Spanish version SF-36 questionnaire</measure>
    <time_frame>Up to 3 months</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Tampa Scale of Kinesiophobia (TSK) (Spanish version)</measure>
    <time_frame>Up to 3 months</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pain Catastrophization Scale (PCS) (Spanish version)</measure>
    <time_frame>Up to 3 months</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Chronic Pain Coping Inventory-42 (Spanish version)</measure>
    <time_frame>Up to 3 months</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Chronic Pain Acceptance Questionnaire (Spanish version)</measure>
    <time_frame>Up to 3 months</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Goniometric assessment of knee flexion and extension range of motion</measure>
    <time_frame>Up to 3 months</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Strength of the hamstrings and quadriceps muscles</measure>
    <time_frame>Up to 3 months</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Timed &quot;Up &amp; Go&quot; (TUG) Test</measure>
    <time_frame>Up to 3 months</time_frame>
    <description>Participants will be required to rise from a standard arm chair, walk at a safe and comfortable pace to a mark 3 m away and then return to a sitting position in the chair. The outcome of the test will be the time to complete the task. Time will be measured on a stopwatch to the nearest one-hundredth of a second.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Central Sensitization Inventory</measure>
    <time_frame>Up to 3 months</time_frame>
    <description>Signs and symptoms suggesting central sensitization will be monitorized using the Central Sensitization Inventory</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">53</enrollment>
  <condition>Osteoarthritis</condition>
  <arm_group>
    <arm_group_label>MT + NE</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>A manual therapy (MT) intervention combined with neuroscience education (NE)</description>
  </arm_group>
  <arm_group>
    <arm_group_label>MT + E</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Manual therapy (MT) intervention plus an educational program based on a traditional patho-anatomical or biomedical model (E)</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>MT + NE</intervention_name>
    <description>Manual therapy will be applied using mobilization with movement (MWM) techniques. MWM will consist of a sustained manual glide of the tibia (either medial, lateral, anterior, posterior, or rotation) during active knee flexion and extension, depending on which are the limited/painful movements for each patient.&#xD;
The content and pictures of the neuroscience education (NE) will be based on the text &quot;Explicando el dolor&quot; (Spanish version of &quot;Explain Pain&quot;).</description>
    <arm_group_label>MT + NE</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>MT + E</intervention_name>
    <description>Program of education based on the traditional biomedical model (i.e. through visualization of several videos related to anatomy, biomechanics and surgical procedure of the knee), plus the same manual treatment as per the MT+NE group</description>
    <arm_group_label>MT + E</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. An established diagnosis of knee OA according to American College of Rheumatology&#xD;
             criteria and Kellgreen/Lawrence scale grades.&#xD;
&#xD;
          2. To be in a waiting list and scheduled to undergo primary knee arthroplasty.&#xD;
&#xD;
          3. To have sufficient Spanish language skills to comprehend all explanations and to&#xD;
             complete the assessment tools.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Previous knee joint replacement surgery of the affected joint or any other lower limb&#xD;
             surgery within the past 6 months.&#xD;
&#xD;
          2. Stated inability to attend or complete the proposed course of intervention and&#xD;
             follow-up schedule.&#xD;
&#xD;
          3. Presence of co-morbidities associated with cognitive impairment.&#xD;
&#xD;
          4. Co-existing inflammatory, metabolic, neurological or severe medical conditions,&#xD;
             defined as a diagnosis in the medical record severe enough that the patient cannot&#xD;
             participate fully in the study procedures (i.e. cardiovascular disease).&#xD;
&#xD;
          5. Functional illiteracy.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>N/A</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Enrique Lluch, PT</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Valencia</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Luis Aguilella, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Hospital Universitario de la Ribera, Alcira (Valencia)</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Luis Aguilella, PhD</last_name>
    <phone>+34962458100</phone>
    <email>luis.aguilella@comv.es</email>
  </overall_contact>
  <location>
    <facility>
      <name>Hospital Universitario de La Ribera</name>
      <address>
        <city>Alcira</city>
        <state>Valencia</state>
        <zip>46600</zip>
        <country>Spain</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <investigator>
      <last_name>Enrique Lluch, PT</last_name>
      <role>Principal Investigator</role>
    </investigator>
    <investigator>
      <last_name>Luis Aguilella, PhD</last_name>
      <role>Principal Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>Spain</country>
  </location_countries>
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  <verification_date>September 2014</verification_date>
  <study_first_submitted>September 15, 2014</study_first_submitted>
  <study_first_submitted_qc>September 19, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 22, 2014</study_first_posted>
  <last_update_submitted>September 19, 2014</last_update_submitted>
  <last_update_submitted_qc>September 19, 2014</last_update_submitted_qc>
  <last_update_posted type="Estimate">September 22, 2014</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>University of Valencia</investigator_affiliation>
    <investigator_full_name>Enrique Lluch Girbés</investigator_full_name>
    <investigator_title>Physiotherapist</investigator_title>
  </responsible_party>
  <keyword>Osteoarthritis, Central Nervous System Sensitization</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Osteoarthritis</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02246088
org study id: EDUART13
nct id: NCT02246088
lead sponsor: 
collaborator: 
has dmc: Yes
Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great
      disability and significant healthcare costs. Substantial scientific evidence indicates a role
      for central sensitization in OA pain. Reconceptualization of pain through Neuroscience
      Education (NE) is an intervention that has already been used successfully in some chronic
      musculoskeletal pain conditions characterized by alteration on CNS pain processing or central
      sensitization (i.e. chronic low back pain, chronic fatigue syndrome, widespread pain and
      chronic whiplash associate disorders).There is compelling evidence that NE have a positive
      effect on pain, disability, catastrophization and physical performance for chronic
      musculoskeletal pain disorders, yet studies examining the value of NE for OA patients are
      essentially lacking.

      The primary aim of this study is to assess the effect of NE on pain, disability and physical
      performance in subjects with chronic OA knee pain waiting for replacement surgery. This will
      be the first time NE will be addressed specifically to OA pain. To investigate the benefits
      of NE on pain related to knee OA, the effect of a manual therapy intervention combined with
      NE (MT+NE) will be compared with this same manual intervention plus an educational program
      based on a traditional patho-anatomical or biomedical model (MT+E). The following secondary
      aims will be addressed as well:

        -  Examining the effects of the two interventions on the mechanism of central sensitization
           in patients with knee OA;

        -  Examining the effects of the two interventions on pain catastrophizing, illness
           perceptions and kinesiophobia in patients with knee OA;

        -  Finally, it is aimed at identifying effect moderators for NE in patients with knee OA.
Osteoarthritis (OA) is a frequent chronic musculoskeletal pathology that usually causes great
      disability and significant healthcare costs. Substantial scientific evidence indicates a role
      for central sensitization in OA pain. Pathophysiological mechanisms underlying central
      sensitisation are complex and numerous, but the net effect is an amplification of neural
      signaling within the CNS than elicits pain hypersensitivity. Central sensitization management
      is an area of great interest at least in a subgroup of patients with OA pain.

      Reconceptualization of pain through Neuroscience Education (NE) is an intervention that has
      already been used successfully in some chronic musculoskeletal pain conditions characterized
      by alteration on CNS pain processing or central sensitization (i.e. chronic low back pain,
      chronic fatigue syndrome, widespread pain and chronic whiplash associate disorders).
      Moreover, some clinical guides to help clinicians to identify and explain central
      sensitization through NE, have been recently published. However, this kind of intervention
      has never been tested specifically for chronic pain related to OA.

      Preoperative education centered on a biomedical model of anatomy and pathoanatomy as well as
      procedural information has limited effect in reducing postoperative pain after total hip
      arthroplasty and total hip arthroplasty surgeries. Preoperative educational sessions that aim
      to increase patient knowledge of pain science (i.e. NE) may be more effective in managing
      postoperative pain. NE is a cognitive-based educational intervention that aims to reduce pain
      and disability by helping patients gain an increased understanding of the biological
      processes underpinning their pain state. There is compelling evidence that NE have a positive
      effect on pain, disability, catastrophization and physical performance for chronic
      musculoskeletal pain disorders, yet studies examining the value of NE for OA patients are
      essentially lacking.

      Joint mobilization has been shown to be a useful modality to reduce pain related to
      osteoarthritis. Regarding the knee joint, two recent systematic reviews demonstrated the
      usefulness of manual therapy and exercise for the management of knee OA. Moreover, Deyle et
      al reported a preliminary clinical prediction rule which may help to identify the minority of
      knee OA patients who are unlikely to respond to this management approach.

      The primary aim of this study is therefore to assess the effect of NE on pain, disability and
      physical performance in subjects with chronic OA knee pain waiting for replacement surgery.
      This will be the first time NE will be addressed specifically to OA pain. To investigate the
      benefits of NE on pain related to knee OA, the effect of a manual therapy intervention
      combined with NE (MT+NE) will be compared with this same manual intervention plus an
      educational program based on a traditional patho-anatomical or biomedical model (MT+E). The
      following secondary aims will be addressed as well:

        -  Examining the effects of the two interventions on the mechanism of central sensitization
           in patients with knee OA;

        -  Examining the effects of the two interventions on pain catastrophizing, illness
           perceptions and kinesiophobia in patients with knee OA;

        -  Finally, it is aimed at identifying effect moderators for NE in patients with knee OA.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Single (Outcomes Assessor)
measure: Endogenous analgesia through the experimental protocol of conditioned pain modulation
time frame: Up to 3 months
description: For assessing endogenous analgesia, the method examining the influence of the Diffuse Noxious Inhibitory Control system (or spatial summation) on temporal summation will be applied. Recently, the term conditioned pain modulation has been recommended to describe the psychophysical paradigm of Diffuse Noxious Inhibitory Control system in humans
measure: Pain at rest and in the last 24 hours
time frame: Up to 3 months
description: Participants will be asked to rate their pain at rest and in the last 24 hours on a horizontal 100-mm visual analogue scale (VAS). The horizontal line anchors will be "no pain" and "worst imaginable pain". The VAS is a valid and reliable instrument compared with other pain rating scales and has been well established in clinical practice and research for measuring pain levels in arthritis populations.
measure: Pressure Pain Thresholds
time frame: Up to 3 months
description: Local and distant sites will be chosen for pressure pain threshold measurement. Regarding local sites, two points will be measured from the knee, 3 cm medial and lateral to the midpoint of the medial and lateral edge of patella, respectively. Regarding control site, a distant site will be used to assess systematic analgesic effect of NE at 5 cm distal to lateral epicondyle.
measure: Western Ontario and McMaster osteoarthritis index (WOMAC scale)
time frame: Up to 3 months
description: WOMAC assesses pain, stiffness and physical function and can be completed in less than 5 minutes. It's a widely used, reliable, valid and responsive measure of outcome in people with osteoarthritis of the hip or knee.
measure: Health-related quality of life using the self-reported Spanish version SF-36 questionnaire
time frame: Up to 3 months
measure: Tampa Scale of Kinesiophobia (TSK) (Spanish version)
time frame: Up to 3 months
measure: Pain Catastrophization Scale (PCS) (Spanish version)
time frame: Up to 3 months
measure: Chronic Pain Coping Inventory-42 (Spanish version)
time frame: Up to 3 months
measure: Chronic Pain Acceptance Questionnaire (Spanish version)
time frame: Up to 3 months
measure: Goniometric assessment of knee flexion and extension range of motion
time frame: Up to 3 months
measure: Strength of the hamstrings and quadriceps muscles
time frame: Up to 3 months
measure: Timed "Up & Go" (TUG) Test
time frame: Up to 3 months
description: Participants will be required to rise from a standard arm chair, walk at a safe and comfortable pace to a mark 3 m away and then return to a sitting position in the chair. The outcome of the test will be the time to complete the task. Time will be measured on a stopwatch to the nearest one-hundredth of a second.
measure: Central Sensitization Inventory
time frame: Up to 3 months
description: Signs and symptoms suggesting central sensitization will be monitorized using the Central Sensitization Inventory
arm group label: MT + NE
arm group type: Experimental
description: A manual therapy (MT) intervention combined with neuroscience education (NE)
arm group label: MT + E
arm group type: Active Comparator
description: Manual therapy (MT) intervention plus an educational program based on a traditional patho-anatomical or biomedical model (E)
intervention type: Procedure
intervention name: MT + NE
description: Manual therapy will be applied using mobilization with movement (MWM) techniques. MWM will consist of a sustained manual glide of the tibia (either medial, lateral, anterior, posterior, or rotation) during active knee flexion and extension, depending on which are the limited/painful movements for each patient.
The content and pictures of the neuroscience education (NE) will be based on the text "Explicando el dolor" (Spanish version of "Explain Pain").
arm group label: MT + NE
intervention type: Procedure
intervention name: MT + E
description: Program of education based on the traditional biomedical model (i.e. through visualization of several videos related to anatomy, biomechanics and surgical procedure of the knee), plus the same manual treatment as per the MT+NE group
arm group label: MT + E
criteria: 
gender: All
minimum age: N/A
maximum age: N/A
healthy volunteers: No
last name: Enrique Lluch, PT
role: Principal Investigator
affiliation: University of Valencia
last name: Luis Aguilella, PhD
role: Principal Investigator
affiliation: Hospital Universitario de la Ribera, Alcira (Valencia)
last name: Luis Aguilella, PhD
phone: +34962458100
email: luis.aguilella@comv.es
facility: 
status: Recruiting
investigator: 
investigator: 
country: Spain
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responsible party type: Principal Investigator
investigator affiliation: University of Valencia
investigator full name: Enrique Lluch Girbés
investigator title: Physiotherapist
mesh term: Osteoarthritis