<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02248428</url>
  </required_header>
  <id_info>
    <org_study_id>NAB20140324</org_study_id>
    <nct_id>NCT02248428</nct_id>
  </id_info>
  <brief_title>Clarithromycin Plus CTd Regimen for Patients With Newly Diagnosed Multiple Myeloma</brief_title>
  <acronym>CTd</acronym>
  <official_title>Clarithromycin Plus CTd (Cyclophosphamide,Thalidomide and Dexamethasone)Regimen for Patients With Newly Diagnosed Multiple Myeloma:a Phase 3 , Multicenter,Randomized, Open-Label Trial.</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Jinling Hospital, China</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Jinling Hospital, China</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      Due to economic reasons, thalidomide is still widely used as a first line drug for Multiple&#xD;
      Myeloma patients in China. However,the efficacy of CTd is still lower than the therapeutic&#xD;
      regimens with new drugs. Clarithromycin may have partly efficacy in association with steroids&#xD;
      and thalidomide for Multiple Myeloma patients. This multicenter, randomized, phase 3 clinical&#xD;
      trial is proposed to explore whether clarithromycin could potentiate responsiveness of CTd&#xD;
      (Cyclophosphamide, Thalidomide and Dexamethasone) regimen in Newly Diagnosed Multiple Myeloma&#xD;
      patients. The trial will also evaluate the side effects caused by the combination of these&#xD;
      drugs.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      This phase III,randomized controlled trial will enroll 130(65 each arm) newly diagnosed&#xD;
      patients with active disease from 4 medical centers in East China.&#xD;
&#xD;
      The participants are randomly equally selected to receive BiCTd regimen arm or CTd regimen&#xD;
      arm. The treatment consists of eight induction and consolidation therapy followed by&#xD;
      maintenance therapy.&#xD;
&#xD;
      BiCTd(Clarithromycin, Cyclophosphamide, Thalidomide and Dexamethasone) regimen arm：&#xD;
&#xD;
      Induction and consolidation Phase:&#xD;
&#xD;
      All patients will also receive aspirin 100mg PO QD while receiving BiCTd. Aspirin will&#xD;
      continue through maintenance.&#xD;
&#xD;
      Clarithromycin 500 mg orally daily on days 1-28,thalidomide 100-200mg orally on days d1-28,&#xD;
      dexamethasone 40 mg orally on days on 1,8,15,22, and cyclophosphamide 300 mg/m^2&#xD;
      intravenously on day 1-3. Eight Cycles were repeated every 28 days.&#xD;
&#xD;
      If efficacy &lt;PR after 4 cycles of induction， or disease progression at anytime，patients will&#xD;
      be quitted.&#xD;
&#xD;
      Maintenance Therapy:&#xD;
&#xD;
      Patients who complete the induction and consolidation regimen could be started on maintenance&#xD;
      therapy as follows: Maintenance with CP (cyclophosphamide 200 mg orally on days 1-14 and&#xD;
      prednisone 30mg twice daily orally on days 1-7,repeated every 28 days) regimen until disease&#xD;
      progression.&#xD;
&#xD;
      CTd regimen arm：&#xD;
&#xD;
      Induction and consolidation Phase:&#xD;
&#xD;
      All patients will also receive aspirin 100mg PO QD while receiving CTd. Aspirin will continue&#xD;
      through maintenance.&#xD;
&#xD;
      Thalidomide 100-200mg orally on days d1-28, dexamethasone 40 mg orally on days on 1,8,15,22,&#xD;
      and cyclophosphamide 300 mg/m^2 intravenously on day 1-3. Eight Cycles were repeated every 28&#xD;
      days.&#xD;
&#xD;
      If efficacy &lt;PR after 4 cycles of induction， or disease progression at anytime，patients will&#xD;
      be quitted.&#xD;
&#xD;
      If no further reduction in the serum and urine M protein in the next cycle，patients may cross&#xD;
      over to BiCTd regimen.&#xD;
&#xD;
      Maintenance Therapy:&#xD;
&#xD;
      Patients who complete the induction and consolidation regimen could be started on maintenance&#xD;
      therapy as follows: Maintenance with CP (cyclophosphamide 200 mg orally on days 1-14 and&#xD;
      prednisone 30mg twice daily orally on days 1-7,repeated every 28 days) regimen until disease&#xD;
      progression Then, patients will be followed up for 24 months after chemotherapy. The&#xD;
      investigators will record all the laboratory and clinical investigations to assess response&#xD;
      at different points of the study. We also assess adverse events (AEs), as graded according to&#xD;
      NCI-Common Toxicity Criteria for Adverse Effects (CTCAE) Version 4.0.Response categories were&#xD;
      based on the International Myeloma Working Group uniform response criteria.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date>April 2012</start_date>
  <completion_date type="Anticipated">September 2020</completion_date>
  <primary_completion_date type="Anticipated">September 2019</primary_completion_date>
  <phase>Phase 3</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Percentage of Participants With Very Good Partial Remission (VGPR) or Better</measure>
    <time_frame>up to 4 months</time_frame>
    <description>Quality of response: % Complete Response (CR) + Very Good Partial Remission (VGPR) to induction BiCTd or CTd as assessed using International Myeloma Working Group Response Definitions. Very Good Partial Remission (VGPR): Detectable serum and urine M component on immunofixation but not on electrophoresis or 90% or greater reduction in serum M protein with less than 100 mg/24 h of urinary M protein. Complete Remission (CR): The presence of less than 5% bone marrow plasmacytosis and the disappearance of all evidence of serum and urine M-components on electrophoresis as well as by immunofixation. In addition, soft tissue plasmacytoma must have disappeared.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Median Progression Free Survival (PFS) in months</measure>
    <time_frame>From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 24 Months</time_frame>
    <description>PFS: Time from study entry to progression/relapse or death from study entry to death of any cause, assessed using International Myeloma Working Group Response Definitions. Progressive Disease (PD): One of the following criteria must be met: a. Increase of 25% or greater in serum M protein (absolute increase greater or equal to 0.5g/dl); b. Increase of 25% or greater in urine M protein (absolute increase greater than 200 mg/24h); c. Increase of 25% or greater in the difference between the involved and uninvolved free light chain (absolute increase greater than 10 mg/dl); d. Increase of 25% or greater in bone marrow plasma cell percentage (absolute percent greater than 5% in case the patient was in CR and 10% otherwise); i.e. Definite development of new bone lesions or soft tissue plasmacytomas, or increase in the size of existing plasmacytomas by greater or equal to 25%. Development of hypercalcemia (serum calcium &gt; 11.5 mg/dl) attributable only to the plasma cell dyscrasia.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>2 Year Overall Survival (OS) Rate</measure>
    <time_frame>up to 24 months</time_frame>
    <description>Percentage of participants with Overall Survival in response to BiCTd or CTd in newly diagnosed multiple myeloma patients with active disease. Overall survival is time from study entry to death of any cause.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Number of participants with adverse events</measure>
    <time_frame>up to 48 months</time_frame>
    <description>Adverse events (AEs) were graded according to NCI-CTCAE Version 4.0</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">130</enrollment>
  <condition>Multiple Myeloma</condition>
  <arm_group>
    <arm_group_label>BiCTd regimen</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Induction and consolidation therapy: BiCTd regimen for 8 cycles. Patients received Clarithromycin 500 mg orally on days 1-28,thalidomide 100-200mg orally on days d1-28, dexamethasone 40mg orally on days on 1,8,15,22, and cyclophosphamide 300mg/m^2 intravenously on day 1-3. Cycles were repeated every 28 days.&#xD;
Maintenance therapy:CP regimen (cyclophosphamide 200 mg orally on days 1-14 and prednisone 30mg twice daily orally on days 1-7,repeated every 28 days) until disease progression.&#xD;
If efficacy &lt;PR after 4 cycles of induction or disease progression at anytime，patients will be quitted.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>CTd regimen</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Induction and consolidation therapy: CTd regimen for 8 cycles. Patients received thalidomide 100-200mg orally on days d1-28, dexamethasone 40 mg orally on days on 1,8,15,22, and cyclophosphamide 300 mg/m^2 intravenously on day 1-3. Cycles were repeated every 28 days.&#xD;
Maintenance therapy:CP regimen (cyclophosphamide 200 mg orally on days 1-14 and prednisone 30mg twice daily orally on days 1-7,28 Days per Cycle) until disease progression.&#xD;
If efficacy &lt;PR after 4 cycles of induction or disease progression at anytime，patients will be quitted.&#xD;
If no further reduction in the serum and urine M protein in the next cycle，patients may cross over to BiCTd regimen.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Clarithromycin</intervention_name>
    <description>500mg orally daily on days 1-28,repeated every 28 days</description>
    <arm_group_label>BiCTd regimen</arm_group_label>
    <other_name>Abbott- 56268</other_name>
    <other_name>Biaxin</other_name>
    <other_name>CLARITH</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Thalidomide</intervention_name>
    <description>Thalidomide 100-200mg orally per night on days 1-28,repeated every 28 days</description>
    <arm_group_label>BiCTd regimen</arm_group_label>
    <arm_group_label>CTd regimen</arm_group_label>
    <other_name>Distaval</other_name>
    <other_name>Thalomid</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Cyclophosphamide</intervention_name>
    <description>300mg/m^2 intravenously daily on day 1-3,repeated every 28 days</description>
    <arm_group_label>BiCTd regimen</arm_group_label>
    <arm_group_label>CTd regimen</arm_group_label>
    <other_name>Endoxan</other_name>
    <other_name>Cytoxan</other_name>
    <other_name>Neosar</other_name>
    <other_name>Procytox</other_name>
    <other_name>Revimmune</other_name>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Dexamethasone</intervention_name>
    <description>40 mg orally weekly on days 1,8,15,22,repeated every 28 days</description>
    <arm_group_label>BiCTd regimen</arm_group_label>
    <arm_group_label>CTd regimen</arm_group_label>
    <other_name>Decadron</other_name>
    <other_name>Aeroseb-Dex</other_name>
    <other_name>Decaderm</other_name>
    <other_name>DM</other_name>
    <other_name>DXM</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Signed informed consent form&#xD;
&#xD;
          -  Able to adhere to the study visit schedule and other protocol requirements&#xD;
&#xD;
          -  Diagnosed with active multiple myeloma&#xD;
&#xD;
          -  Previously untreated&#xD;
&#xD;
          -  Karnofsky performance status(KPS) ≥50（KPS&lt;50 will be allowed if related to bony&#xD;
             disease）&#xD;
&#xD;
          -  New York Heart Association(NYHA) functional ≤class III&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Hypersensitivity to clarithromycin or any of its excipients, erythromycin, or any of&#xD;
             the macrolide antibiotics;&#xD;
&#xD;
          -  Concomitant administration of cisapride, pimozide, astemizole, terfenadine, ergotamine&#xD;
             or dihydroergotamine, simvastatin, lovastatin, and atorvastatin;&#xD;
&#xD;
          -  A history of cholestatic jaundice/hepatic dysfunction associated with prior use of&#xD;
             clarithromycin.&#xD;
&#xD;
          -  Impaired renal function,Creatinine ≥221umol/L；&#xD;
&#xD;
          -  Pregnant or breast feeding females.&#xD;
&#xD;
          -  Any condition which places the subject at unacceptable risk if he/she were to&#xD;
             participate in the study or confounds the ability to interpret data from the study.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Yongping Zhai, doctor</last_name>
    <role>Study Chair</role>
    <affiliation>Jinling Hospital, China</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Yongping Zhai, doctor</last_name>
    <phone>13951947646</phone>
    <email>ypzhai@medmail.com.cn</email>
  </overall_contact>
  <location>
    <facility>
      <name>Jinling Hospital</name>
      <address>
        <city>Nanjing</city>
        <state>Jiangsu</state>
        <zip>210002</zip>
        <country>China</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Zhai, doctor</last_name>
      <phone>13951947646</phone>
      <email>ypzhai@medmail.com.cn</email>
    </contact>
    <investigator>
      <last_name>Yongping Zhai, doctor</last_name>
      <role>Principal Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
  <verification_date>September 2017</verification_date>
  <study_first_submitted>September 22, 2014</study_first_submitted>
  <study_first_submitted_qc>September 24, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 25, 2014</study_first_posted>
  <last_update_submitted>September 4, 2017</last_update_submitted>
  <last_update_submitted_qc>September 4, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">September 6, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Jinling Hospital, China</investigator_affiliation>
    <investigator_full_name>Yongping Zhai</investigator_full_name>
    <investigator_title>Department of hemotology</investigator_title>
  </responsible_party>
  <keyword>multiple myeloma</keyword>
  <keyword>Clarithromycin</keyword>
  <keyword>CTd</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Multiple Myeloma</mesh_term>
    <mesh_term>Neoplasms, Plasma Cell</mesh_term>
  </condition_browse>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Clarithromycin</mesh_term>
    <mesh_term>Thalidomide</mesh_term>
    <mesh_term>Dexamethasone</mesh_term>
    <mesh_term>Cyclophosphamide</mesh_term>
  </intervention_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02248428
org study id: NAB20140324
nct id: NCT02248428
lead sponsor: 
has dmc: Yes
Due to economic reasons, thalidomide is still widely used as a first line drug for Multiple
      Myeloma patients in China. However,the efficacy of CTd is still lower than the therapeutic
      regimens with new drugs. Clarithromycin may have partly efficacy in association with steroids
      and thalidomide for Multiple Myeloma patients. This multicenter, randomized, phase 3 clinical
      trial is proposed to explore whether clarithromycin could potentiate responsiveness of CTd
      (Cyclophosphamide, Thalidomide and Dexamethasone) regimen in Newly Diagnosed Multiple Myeloma
      patients. The trial will also evaluate the side effects caused by the combination of these
      drugs.
This phase III,randomized controlled trial will enroll 130(65 each arm) newly diagnosed
      patients with active disease from 4 medical centers in East China.

      The participants are randomly equally selected to receive BiCTd regimen arm or CTd regimen
      arm. The treatment consists of eight induction and consolidation therapy followed by
      maintenance therapy.

      BiCTd(Clarithromycin, Cyclophosphamide, Thalidomide and Dexamethasone) regimen arm：

      Induction and consolidation Phase:

      All patients will also receive aspirin 100mg PO QD while receiving BiCTd. Aspirin will
      continue through maintenance.

      Clarithromycin 500 mg orally daily on days 1-28,thalidomide 100-200mg orally on days d1-28,
      dexamethasone 40 mg orally on days on 1,8,15,22, and cyclophosphamide 300 mg/m^2
      intravenously on day 1-3. Eight Cycles were repeated every 28 days.

      If efficacy <PR after 4 cycles of induction， or disease progression at anytime，patients will
      be quitted.

      Maintenance Therapy:

      Patients who complete the induction and consolidation regimen could be started on maintenance
      therapy as follows: Maintenance with CP (cyclophosphamide 200 mg orally on days 1-14 and
      prednisone 30mg twice daily orally on days 1-7,repeated every 28 days) regimen until disease
      progression.

      CTd regimen arm：

      Induction and consolidation Phase:

      All patients will also receive aspirin 100mg PO QD while receiving CTd. Aspirin will continue
      through maintenance.

      Thalidomide 100-200mg orally on days d1-28, dexamethasone 40 mg orally on days on 1,8,15,22,
      and cyclophosphamide 300 mg/m^2 intravenously on day 1-3. Eight Cycles were repeated every 28
      days.

      If efficacy <PR after 4 cycles of induction， or disease progression at anytime，patients will
      be quitted.

      If no further reduction in the serum and urine M protein in the next cycle，patients may cross
      over to BiCTd regimen.

      Maintenance Therapy:

      Patients who complete the induction and consolidation regimen could be started on maintenance
      therapy as follows: Maintenance with CP (cyclophosphamide 200 mg orally on days 1-14 and
      prednisone 30mg twice daily orally on days 1-7,repeated every 28 days) regimen until disease
      progression Then, patients will be followed up for 24 months after chemotherapy. The
      investigators will record all the laboratory and clinical investigations to assess response
      at different points of the study. We also assess adverse events (AEs), as graded according to
      NCI-Common Toxicity Criteria for Adverse Effects (CTCAE) Version 4.0.Response categories were
      based on the International Myeloma Working Group uniform response criteria.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Percentage of Participants With Very Good Partial Remission (VGPR) or Better
time frame: up to 4 months
description: Quality of response: % Complete Response (CR) + Very Good Partial Remission (VGPR) to induction BiCTd or CTd as assessed using International Myeloma Working Group Response Definitions. Very Good Partial Remission (VGPR): Detectable serum and urine M component on immunofixation but not on electrophoresis or 90% or greater reduction in serum M protein with less than 100 mg/24 h of urinary M protein. Complete Remission (CR): The presence of less than 5% bone marrow plasmacytosis and the disappearance of all evidence of serum and urine M-components on electrophoresis as well as by immunofixation. In addition, soft tissue plasmacytoma must have disappeared.
measure: Median Progression Free Survival (PFS) in months
time frame: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 24 Months
description: PFS: Time from study entry to progression/relapse or death from study entry to death of any cause, assessed using International Myeloma Working Group Response Definitions. Progressive Disease (PD): One of the following criteria must be met: a. Increase of 25% or greater in serum M protein (absolute increase greater or equal to 0.5g/dl); b. Increase of 25% or greater in urine M protein (absolute increase greater than 200 mg/24h); c. Increase of 25% or greater in the difference between the involved and uninvolved free light chain (absolute increase greater than 10 mg/dl); d. Increase of 25% or greater in bone marrow plasma cell percentage (absolute percent greater than 5% in case the patient was in CR and 10% otherwise); i.e. Definite development of new bone lesions or soft tissue plasmacytomas, or increase in the size of existing plasmacytomas by greater or equal to 25%. Development of hypercalcemia (serum calcium > 11.5 mg/dl) attributable only to the plasma cell dyscrasia.
measure: 2 Year Overall Survival (OS) Rate
time frame: up to 24 months
description: Percentage of participants with Overall Survival in response to BiCTd or CTd in newly diagnosed multiple myeloma patients with active disease. Overall survival is time from study entry to death of any cause.
measure: Number of participants with adverse events
time frame: up to 48 months
description: Adverse events (AEs) were graded according to NCI-CTCAE Version 4.0
arm group label: BiCTd regimen
arm group type: Experimental
description: Induction and consolidation therapy: BiCTd regimen for 8 cycles. Patients received Clarithromycin 500 mg orally on days 1-28,thalidomide 100-200mg orally on days d1-28, dexamethasone 40mg orally on days on 1,8,15,22, and cyclophosphamide 300mg/m^2 intravenously on day 1-3. Cycles were repeated every 28 days.
Maintenance therapy:CP regimen (cyclophosphamide 200 mg orally on days 1-14 and prednisone 30mg twice daily orally on days 1-7,repeated every 28 days) until disease progression.
If efficacy <PR after 4 cycles of induction or disease progression at anytime，patients will be quitted.
arm group label: CTd regimen
arm group type: Active Comparator
description: Induction and consolidation therapy: CTd regimen for 8 cycles. Patients received thalidomide 100-200mg orally on days d1-28, dexamethasone 40 mg orally on days on 1,8,15,22, and cyclophosphamide 300 mg/m^2 intravenously on day 1-3. Cycles were repeated every 28 days.
Maintenance therapy:CP regimen (cyclophosphamide 200 mg orally on days 1-14 and prednisone 30mg twice daily orally on days 1-7,28 Days per Cycle) until disease progression.
If efficacy <PR after 4 cycles of induction or disease progression at anytime，patients will be quitted.
If no further reduction in the serum and urine M protein in the next cycle，patients may cross over to BiCTd regimen.
intervention type: Drug
intervention name: Clarithromycin
description: 500mg orally daily on days 1-28,repeated every 28 days
arm group label: BiCTd regimen
other name: Abbott- 56268
other name: Biaxin
other name: CLARITH
intervention type: Drug
intervention name: Thalidomide
description: Thalidomide 100-200mg orally per night on days 1-28,repeated every 28 days
arm group label: BiCTd regimen
arm group label: CTd regimen
other name: Distaval
other name: Thalomid
intervention type: Drug
intervention name: Cyclophosphamide
description: 300mg/m^2 intravenously daily on day 1-3,repeated every 28 days
arm group label: BiCTd regimen
arm group label: CTd regimen
other name: Endoxan
other name: Cytoxan
other name: Neosar
other name: Procytox
other name: Revimmune
intervention type: Drug
intervention name: Dexamethasone
description: 40 mg orally weekly on days 1,8,15,22,repeated every 28 days
arm group label: BiCTd regimen
arm group label: CTd regimen
other name: Decadron
other name: Aeroseb-Dex
other name: Decaderm
other name: DM
other name: DXM
criteria: 
gender: All
minimum age: 18 Years
maximum age: N/A
healthy volunteers: No
last name: Yongping Zhai, doctor
role: Study Chair
affiliation: Jinling Hospital, China
last name: Yongping Zhai, doctor
phone: 13951947646
email: ypzhai@medmail.com.cn
facility: 
status: Recruiting
contact: 
investigator: 
country: China
responsible party type: Principal Investigator
investigator affiliation: Jinling Hospital, China
investigator full name: Yongping Zhai
investigator title: Department of hemotology
mesh term: Multiple Myeloma
mesh term: Neoplasms, Plasma Cell
mesh term: Clarithromycin
mesh term: Thalidomide
mesh term: Dexamethasone
mesh term: Cyclophosphamide