<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02239549</url>
  </required_header>
  <id_info>
    <org_study_id>H130473</org_study_id>
    <secondary_id>090012</secondary_id>
    <nct_id>NCT02239549</nct_id>
  </id_info>
  <brief_title>Biopsy Forceps Versus Cold Snare for the Resection of Small Colonic Polyps</brief_title>
  <official_title>A Prospective Randomized Study Comparing Jumbo Cold Biopsy Forceps Versus Cold Snare for the Resection of Small Colonic Polyps</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>San Diego Veterans Healthcare System</agency>
      <agency_class>U.S. Fed</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>University of California, San Diego</agency>
      <agency_class>Other</agency_class>
    </collaborator>
  </sponsors>
  <source>San Diego Veterans Healthcare System</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The purpose of this study is to evaluate and compare the incomplete resection rates for small&#xD;
      colon polyps less than or equal to 6 mm in size using two conventional polypectomy tools,&#xD;
      jumbo cold biopsy forceps and cold snare.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The study is a prospective, randomized controlled study involving outpatients undergoing&#xD;
      routine colonoscopy. The study is conducted at two academic medical centers, the Veterans&#xD;
      Affairs (VA) San Diego Healthcare System and the University of California San Diego (UCSD)&#xD;
      Thornton Hospital. Written informed consent is obtained from all participants prior to any&#xD;
      study related procedures. Upon enrollment, each patient is randomized via a computer&#xD;
      generated randomization scheme to a polypectomy device, either jumbo cold biopsy forceps or&#xD;
      cold snare. The randomly allocated polypectomy device is used for polyp resection for polyps&#xD;
      less than or equal to 6 mm in size.&#xD;
&#xD;
      All patients undergo standard bowel preparation with 4 liters of polyethylene glycol solution&#xD;
      for routine colonoscopy. All colonoscopies are performed using standard colonoscopes (Olympus&#xD;
      CF/PCF 160, CF/PCF 180, H-CF/H-PCF 180). Polypectomy tools used are: Olympus Biopsy Forceps,&#xD;
      Boston Scientific RJ4 Biopsy Forceps, Boston Scientific Captiflex Extra Small Oval Flexible&#xD;
      Snare, US Endoscopy Dsnare Dimunitive Polypectomy and Suction System, and the Boston&#xD;
      Scientific Sensation Short Throw Oval Flexible Snare. For all polyps less than or equal to 6&#xD;
      mm in size, documentation of polyp size and anatomic location is conducted.&#xD;
&#xD;
      The jumbo capacity cold forceps polypectomy technique is performed via the following method:&#xD;
      After inspection of the polyp, one or more biopsies are taken of the polyp followed by&#xD;
      retrieval of the specimens directly from the biopsy forceps. Thereafter, the polypectomy site&#xD;
      is vigorously irrigated and visually inspected for evidence of residual polypoid tissue. If&#xD;
      residual polypoid tissue is suspected, additional biopsies are taken until the site is&#xD;
      considered devoid of polypoid tissue. The total number of bites required for visual&#xD;
      completion of polypectomy is recorded.&#xD;
&#xD;
      The cold snare polypectomy technique is performed via the following method: After inspection&#xD;
      of the polyp, the snare is used to encircle the polyp with a few millimeter rim of&#xD;
      surrounding normal mucosa. The cold snare is used to mechanically transect the polyp without&#xD;
      tenting. Thereafter, the resected polyp specimen is suctioned through the colonoscope channel&#xD;
      into a trap and retrieval is documented. Next, the polypectomy site is vigorously irrigated&#xD;
      and visually inspected for evidence of residual polypoid tissue. If polypoid tissue is still&#xD;
      suspected, additional snare excision is performed. The total number of snare excisions&#xD;
      required for visual completion of polypectomy is recorded.&#xD;
&#xD;
      For both polypectomy methods, after polyp removal is considered complete, the base and&#xD;
      perimeter of the polypectomy site is sampled with a jumbo capacity biopsy forceps with one to&#xD;
      three additional biopsies to evaluate for the presence of residual polypoid tissue. All&#xD;
      pathology results for the polyp specimens and the polypectomy base specimens are interpreted&#xD;
      by a group of VA or UCSD affiliated pathologists.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date>April 2009</start_date>
  <completion_date type="Actual">March 2014</completion_date>
  <primary_completion_date type="Actual">May 2012</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Incomplete resection rate</measure>
    <time_frame>One week after colonoscopy date (when pathology results are available)</time_frame>
    <description>Resected polyp tissue is collected in a unique specimen jar. Tissue from the perimeter and base of the polyp resection site is collected in separate specimen jar. Histological examination by the pathologist is conducted.&#xD;
Incomplete resection rate = Number of polyps with residual polyp tissue present in biopsy of the perimeter and base of the polypectomy resection site / Total number of polyps This is calculated for polypectomies utilizing either jumbo capacity biopsy forceps or cold snare.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Rate of tissue retrieval</measure>
    <time_frame>1 day (At time of colonoscopy)</time_frame>
    <description>Documentation of whether resected polyp tissue is actually retrieved for placement into specimen jar.&#xD;
Rate of tissue retrieval = Number of effectively retrieved polyps for placement into specimen jar / Total number of resected polyps</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Rate of procedure-related complications</measure>
    <time_frame>1 day (At time of colonoscopy)</time_frame>
    <description>The two procedure related complications that were specifically assessed were post-polypectomy bleeding or perforation.&#xD;
Rate of procedure-related complications = Number of colonoscopies with complication of post-polypectomy bleeding or perforation / Total number of colonoscopies</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">419</enrollment>
  <condition>Colonic Polyps</condition>
  <arm_group>
    <arm_group_label>Jumbo cold forceps polypectomy group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Polypectomy conducted with jumbo cold forceps</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Cold snare polypectomy group</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Polypectomy conducted with cold snare</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Jumbo cold forceps polypectomy</intervention_name>
    <description>The specific jumbo cold forceps used are the Olympus EndoJaw Biopsy Forceps (open jaw diameter 8.5 mm) and the Boston Scientific RJ4 Biopsy Forceps (open jaw diameter 8.8 mm).</description>
    <arm_group_label>Jumbo cold forceps polypectomy group</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Cold snare polypectomy</intervention_name>
    <description>The specific cold snares used are the Boston Scientific Captiflex Extra Small Oval Flexible Snare (loop width 11 mm), the US Endoscopy Dsnare Dimunitive Polypectomy and Suction System (loop width 9 mm), or the Boston Scientific Sensation Short Throw Oval Flexible Snare (loop width of 13 mm, 27 mm, or 30 mm).</description>
    <arm_group_label>Cold snare polypectomy group</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patients between the ages of 18 and 80 years&#xD;
&#xD;
          -  Undergoing routine colonoscopy&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Inflammatory bowel disease&#xD;
&#xD;
          -  Cognitive impairment&#xD;
&#xD;
          -  Pregnancy&#xD;
&#xD;
          -  Presence of a coagulation disorder&#xD;
&#xD;
          -  Use of anticoagulant, antiplatelet, or non-steroidal anti-inflammatory drug therapy&#xD;
             during the 1 week prior to colonoscopy&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>80 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Mary Lee Krinsky, D.O.</last_name>
    <role>Principal Investigator</role>
    <affiliation>San Diego Veterans Affairs Health Care System</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Veterans Affairs San Diego Healthcare System</name>
      <address>
        <city>San Diego</city>
        <state>California</state>
        <zip>92161</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <reference>
    <citation>Pohl H, Srivastava A, Bensen SP, Anderson P, Rothstein RI, Gordon SR, Levy LC, Toor A, Mackenzie TA, Rosch T, Robertson DJ. Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology. 2013 Jan;144(1):74-80.e1. doi: 10.1053/j.gastro.2012.09.043. Epub 2012 Sep 25. Erratum In: Gastroenterology. 2021 Oct;161(4):1347.</citation>
    <PMID>23022496</PMID>
  </reference>
  <reference>
    <citation>Church JM. Clinical significance of small colorectal polyps. Dis Colon Rectum. 2004 Apr;47(4):481-5. doi: 10.1007/s10350-003-0078-6. Epub 2004 Mar 4.</citation>
    <PMID>14994108</PMID>
  </reference>
  <reference>
    <citation>Kapsoritakis AN, Potamianos SP, Koukourakis MI, Tzardi M, Mouzas IA, Roussomoustakaki M, Alexandrakis G, Kouroumalis EA. Diminutive polyps of large bowel should be an early target for endoscopic treatment. Dig Liver Dis. 2002 Feb;34(2):137-40. doi: 10.1016/s1590-8658(02)80244-4.</citation>
    <PMID>11926558</PMID>
  </reference>
  <reference>
    <citation>Efthymiou M, Taylor AC, Desmond PV, Allen PB, Chen RY. Biopsy forceps is inadequate for the resection of diminutive polyps. Endoscopy. 2011 Apr;43(4):312-6. doi: 10.1055/s-0030-1256086. Epub 2011 Mar 16.</citation>
    <PMID>21412704</PMID>
  </reference>
  <reference>
    <citation>Jung YS, Park JH, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Sohn JH, Park DI. Complete biopsy resection of diminutive polyps. Endoscopy. 2013 Dec;45(12):1024-9. doi: 10.1055/s-0033-1344394. Epub 2013 Aug 6.</citation>
    <PMID>23921846</PMID>
  </reference>
  <reference>
    <citation>Lee CK, Shim JJ, Jang JY. Cold snare polypectomy vs. Cold forceps polypectomy using double-biopsy technique for removal of diminutive colorectal polyps: a prospective randomized study. Am J Gastroenterol. 2013 Oct;108(10):1593-600. doi: 10.1038/ajg.2013.302. Epub 2013 Sep 17.</citation>
    <PMID>24042189</PMID>
  </reference>
  <reference>
    <citation>Liu S, Ho SB, Krinsky ML. Quality of polyp resection during colonoscopy: are we achieving polyp clearance? Dig Dis Sci. 2012 Jul;57(7):1786-91. doi: 10.1007/s10620-012-2115-6. Epub 2012 Mar 30.</citation>
    <PMID>22461018</PMID>
  </reference>
  <reference>
    <citation>Woods A, Sanowski RA, Wadas DD, Manne RK, Friess SW. Eradication of diminutive polyps: a prospective evaluation of bipolar coagulation versus conventional biopsy removal. Gastrointest Endosc. 1989 Nov-Dec;35(6):536-40. doi: 10.1016/s0016-5107(89)72906-0.</citation>
    <PMID>2689263</PMID>
  </reference>
  <reference>
    <citation>Elmunzer BJ, Higgins PD, Kwon YM, Golembeski C, Greenson JK, Korsnes SJ, Elta GH. Jumbo forceps are superior to standard large-capacity forceps in obtaining diagnostically adequate inflammatory bowel disease surveillance biopsy specimens. Gastrointest Endosc. 2008 Aug;68(2):273-8; quiz 334, 336. doi: 10.1016/j.gie.2007.11.023. Epub 2007 Dec 26.</citation>
    <PMID>18155204</PMID>
  </reference>
  <reference>
    <citation>Draganov PV, Chang MN, Alkhasawneh A, Dixon LR, Lieb J, Moshiree B, Polyak S, Sultan S, Collins D, Suman A, Valentine JF, Wagh MS, Habashi SL, Forsmark CE. Randomized, controlled trial of standard, large-capacity versus jumbo biopsy forceps for polypectomy of small, sessile, colorectal polyps. Gastrointest Endosc. 2012 Jan;75(1):118-26. doi: 10.1016/j.gie.2011.08.019.</citation>
    <PMID>22196811</PMID>
  </reference>
  <reference>
    <citation>Deenadayalu VP, Rex DK. Colon polyp retrieval after cold snaring. Gastrointest Endosc. 2005 Aug;62(2):253-6. doi: 10.1016/s0016-5107(05)00376-7.</citation>
    <PMID>16046990</PMID>
  </reference>
  <reference>
    <citation>Ichise Y, Horiuchi A, Nakayama Y, Tanaka N. Prospective randomized comparison of cold snare polypectomy and conventional polypectomy for small colorectal polyps. Digestion. 2011;84(1):78-81. doi: 10.1159/000323959. Epub 2011 Apr 14.</citation>
    <PMID>21494037</PMID>
  </reference>
  <reference>
    <citation>Komeda Y, Suzuki N, Sarah M, Thomas-Gibson S, Vance M, Fraser C, Patel K, Saunders BP. Factors associated with failed polyp retrieval at screening colonoscopy. Gastrointest Endosc. 2013 Mar;77(3):395-400. doi: 10.1016/j.gie.2012.10.007. Epub 2012 Dec 1.</citation>
    <PMID>23211749</PMID>
  </reference>
  <reference>
    <citation>Tappero G, Gaia E, De Giuli P, Martini S, Gubetta L, Emanuelli G. Cold snare excision of small colorectal polyps. Gastrointest Endosc. 1992 May-Jun;38(3):310-3. doi: 10.1016/s0016-5107(92)70422-2.</citation>
    <PMID>1607081</PMID>
  </reference>
  <reference>
    <citation>Repici A, Hassan C, Vitetta E, Ferrara E, Manes G, Gullotti G, Princiotta A, Dulbecco P, Gaffuri N, Bettoni E, Pagano N, Rando G, Strangio G, Carlino A, Romeo F, de Paula Pessoa Ferreira D, Zullo A, Ridola L, Malesci A. Safety of cold polypectomy for &lt;10mm polyps at colonoscopy: a prospective multicenter study. Endoscopy. 2012 Jan;44(1):27-31. doi: 10.1055/s-0031-1291387. Epub 2011 Nov 28.</citation>
    <PMID>22125197</PMID>
  </reference>
  <verification_date>September 2014</verification_date>
  <study_first_submitted>September 10, 2014</study_first_submitted>
  <study_first_submitted_qc>September 11, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 12, 2014</study_first_posted>
  <last_update_submitted>September 11, 2014</last_update_submitted>
  <last_update_submitted_qc>September 11, 2014</last_update_submitted_qc>
  <last_update_posted type="Estimate">September 12, 2014</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>San Diego Veterans Healthcare System</investigator_affiliation>
    <investigator_full_name>Dr. Mary Krinsky</investigator_full_name>
    <investigator_title>Clinical Professor of Medicine</investigator_title>
  </responsible_party>
  <keyword>Colonic Polyps</keyword>
  <keyword>Polypectomy</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Polyps</mesh_term>
    <mesh_term>Colonic Polyps</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02239549
org study id: H130473
secondary id: 090012
nct id: NCT02239549
lead sponsor: 
collaborator: 
has dmc: Yes
The purpose of this study is to evaluate and compare the incomplete resection rates for small
      colon polyps less than or equal to 6 mm in size using two conventional polypectomy tools,
      jumbo cold biopsy forceps and cold snare.
The study is a prospective, randomized controlled study involving outpatients undergoing
      routine colonoscopy. The study is conducted at two academic medical centers, the Veterans
      Affairs (VA) San Diego Healthcare System and the University of California San Diego (UCSD)
      Thornton Hospital. Written informed consent is obtained from all participants prior to any
      study related procedures. Upon enrollment, each patient is randomized via a computer
      generated randomization scheme to a polypectomy device, either jumbo cold biopsy forceps or
      cold snare. The randomly allocated polypectomy device is used for polyp resection for polyps
      less than or equal to 6 mm in size.

      All patients undergo standard bowel preparation with 4 liters of polyethylene glycol solution
      for routine colonoscopy. All colonoscopies are performed using standard colonoscopes (Olympus
      CF/PCF 160, CF/PCF 180, H-CF/H-PCF 180). Polypectomy tools used are: Olympus Biopsy Forceps,
      Boston Scientific RJ4 Biopsy Forceps, Boston Scientific Captiflex Extra Small Oval Flexible
      Snare, US Endoscopy Dsnare Dimunitive Polypectomy and Suction System, and the Boston
      Scientific Sensation Short Throw Oval Flexible Snare. For all polyps less than or equal to 6
      mm in size, documentation of polyp size and anatomic location is conducted.

      The jumbo capacity cold forceps polypectomy technique is performed via the following method:
      After inspection of the polyp, one or more biopsies are taken of the polyp followed by
      retrieval of the specimens directly from the biopsy forceps. Thereafter, the polypectomy site
      is vigorously irrigated and visually inspected for evidence of residual polypoid tissue. If
      residual polypoid tissue is suspected, additional biopsies are taken until the site is
      considered devoid of polypoid tissue. The total number of bites required for visual
      completion of polypectomy is recorded.

      The cold snare polypectomy technique is performed via the following method: After inspection
      of the polyp, the snare is used to encircle the polyp with a few millimeter rim of
      surrounding normal mucosa. The cold snare is used to mechanically transect the polyp without
      tenting. Thereafter, the resected polyp specimen is suctioned through the colonoscope channel
      into a trap and retrieval is documented. Next, the polypectomy site is vigorously irrigated
      and visually inspected for evidence of residual polypoid tissue. If polypoid tissue is still
      suspected, additional snare excision is performed. The total number of snare excisions
      required for visual completion of polypectomy is recorded.

      For both polypectomy methods, after polyp removal is considered complete, the base and
      perimeter of the polypectomy site is sampled with a jumbo capacity biopsy forceps with one to
      three additional biopsies to evaluate for the presence of residual polypoid tissue. All
      pathology results for the polyp specimens and the polypectomy base specimens are interpreted
      by a group of VA or UCSD affiliated pathologists.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Incomplete resection rate
time frame: One week after colonoscopy date (when pathology results are available)
description: Resected polyp tissue is collected in a unique specimen jar. Tissue from the perimeter and base of the polyp resection site is collected in separate specimen jar. Histological examination by the pathologist is conducted.
Incomplete resection rate = Number of polyps with residual polyp tissue present in biopsy of the perimeter and base of the polypectomy resection site / Total number of polyps This is calculated for polypectomies utilizing either jumbo capacity biopsy forceps or cold snare.
measure: Rate of tissue retrieval
time frame: 1 day (At time of colonoscopy)
description: Documentation of whether resected polyp tissue is actually retrieved for placement into specimen jar.
Rate of tissue retrieval = Number of effectively retrieved polyps for placement into specimen jar / Total number of resected polyps
measure: Rate of procedure-related complications
time frame: 1 day (At time of colonoscopy)
description: The two procedure related complications that were specifically assessed were post-polypectomy bleeding or perforation.
Rate of procedure-related complications = Number of colonoscopies with complication of post-polypectomy bleeding or perforation / Total number of colonoscopies
arm group label: Jumbo cold forceps polypectomy group
arm group type: Experimental
description: Polypectomy conducted with jumbo cold forceps
arm group label: Cold snare polypectomy group
arm group type: Experimental
description: Polypectomy conducted with cold snare
intervention type: Device
intervention name: Jumbo cold forceps polypectomy
description: The specific jumbo cold forceps used are the Olympus EndoJaw Biopsy Forceps (open jaw diameter 8.5 mm) and the Boston Scientific RJ4 Biopsy Forceps (open jaw diameter 8.8 mm).
arm group label: Jumbo cold forceps polypectomy group
intervention type: Device
intervention name: Cold snare polypectomy
description: The specific cold snares used are the Boston Scientific Captiflex Extra Small Oval Flexible Snare (loop width 11 mm), the US Endoscopy Dsnare Dimunitive Polypectomy and Suction System (loop width 9 mm), or the Boston Scientific Sensation Short Throw Oval Flexible Snare (loop width of 13 mm, 27 mm, or 30 mm).
arm group label: Cold snare polypectomy group
criteria: 
gender: All
minimum age: 18 Years
maximum age: 80 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Mary Lee Krinsky, D.O.
role: Principal Investigator
affiliation: San Diego Veterans Affairs Health Care System
facility: 
country: United States
citation: Pohl H, Srivastava A, Bensen SP, Anderson P, Rothstein RI, Gordon SR, Levy LC, Toor A, Mackenzie TA, Rosch T, Robertson DJ. Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology. 2013 Jan;144(1):74-80.e1. doi: 10.1053/j.gastro.2012.09.043. Epub 2012 Sep 25. Erratum In: Gastroenterology. 2021 Oct;161(4):1347.
PMID: 23022496
citation: Church JM. Clinical significance of small colorectal polyps. Dis Colon Rectum. 2004 Apr;47(4):481-5. doi: 10.1007/s10350-003-0078-6. Epub 2004 Mar 4.
PMID: 14994108
citation: Kapsoritakis AN, Potamianos SP, Koukourakis MI, Tzardi M, Mouzas IA, Roussomoustakaki M, Alexandrakis G, Kouroumalis EA. Diminutive polyps of large bowel should be an early target for endoscopic treatment. Dig Liver Dis. 2002 Feb;34(2):137-40. doi: 10.1016/s1590-8658(02)80244-4.
PMID: 11926558
citation: Efthymiou M, Taylor AC, Desmond PV, Allen PB, Chen RY. Biopsy forceps is inadequate for the resection of diminutive polyps. Endoscopy. 2011 Apr;43(4):312-6. doi: 10.1055/s-0030-1256086. Epub 2011 Mar 16.
PMID: 21412704
citation: Jung YS, Park JH, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Sohn JH, Park DI. Complete biopsy resection of diminutive polyps. Endoscopy. 2013 Dec;45(12):1024-9. doi: 10.1055/s-0033-1344394. Epub 2013 Aug 6.
PMID: 23921846
citation: Lee CK, Shim JJ, Jang JY. Cold snare polypectomy vs. Cold forceps polypectomy using double-biopsy technique for removal of diminutive colorectal polyps: a prospective randomized study. Am J Gastroenterol. 2013 Oct;108(10):1593-600. doi: 10.1038/ajg.2013.302. Epub 2013 Sep 17.
PMID: 24042189
citation: Liu S, Ho SB, Krinsky ML. Quality of polyp resection during colonoscopy: are we achieving polyp clearance? Dig Dis Sci. 2012 Jul;57(7):1786-91. doi: 10.1007/s10620-012-2115-6. Epub 2012 Mar 30.
PMID: 22461018
citation: Woods A, Sanowski RA, Wadas DD, Manne RK, Friess SW. Eradication of diminutive polyps: a prospective evaluation of bipolar coagulation versus conventional biopsy removal. Gastrointest Endosc. 1989 Nov-Dec;35(6):536-40. doi: 10.1016/s0016-5107(89)72906-0.
PMID: 2689263
citation: Elmunzer BJ, Higgins PD, Kwon YM, Golembeski C, Greenson JK, Korsnes SJ, Elta GH. Jumbo forceps are superior to standard large-capacity forceps in obtaining diagnostically adequate inflammatory bowel disease surveillance biopsy specimens. Gastrointest Endosc. 2008 Aug;68(2):273-8; quiz 334, 336. doi: 10.1016/j.gie.2007.11.023. Epub 2007 Dec 26.
PMID: 18155204
citation: Draganov PV, Chang MN, Alkhasawneh A, Dixon LR, Lieb J, Moshiree B, Polyak S, Sultan S, Collins D, Suman A, Valentine JF, Wagh MS, Habashi SL, Forsmark CE. Randomized, controlled trial of standard, large-capacity versus jumbo biopsy forceps for polypectomy of small, sessile, colorectal polyps. Gastrointest Endosc. 2012 Jan;75(1):118-26. doi: 10.1016/j.gie.2011.08.019.
PMID: 22196811
citation: Deenadayalu VP, Rex DK. Colon polyp retrieval after cold snaring. Gastrointest Endosc. 2005 Aug;62(2):253-6. doi: 10.1016/s0016-5107(05)00376-7.
PMID: 16046990
citation: Ichise Y, Horiuchi A, Nakayama Y, Tanaka N. Prospective randomized comparison of cold snare polypectomy and conventional polypectomy for small colorectal polyps. Digestion. 2011;84(1):78-81. doi: 10.1159/000323959. Epub 2011 Apr 14.
PMID: 21494037
citation: Komeda Y, Suzuki N, Sarah M, Thomas-Gibson S, Vance M, Fraser C, Patel K, Saunders BP. Factors associated with failed polyp retrieval at screening colonoscopy. Gastrointest Endosc. 2013 Mar;77(3):395-400. doi: 10.1016/j.gie.2012.10.007. Epub 2012 Dec 1.
PMID: 23211749
citation: Tappero G, Gaia E, De Giuli P, Martini S, Gubetta L, Emanuelli G. Cold snare excision of small colorectal polyps. Gastrointest Endosc. 1992 May-Jun;38(3):310-3. doi: 10.1016/s0016-5107(92)70422-2.
PMID: 1607081
citation: Repici A, Hassan C, Vitetta E, Ferrara E, Manes G, Gullotti G, Princiotta A, Dulbecco P, Gaffuri N, Bettoni E, Pagano N, Rando G, Strangio G, Carlino A, Romeo F, de Paula Pessoa Ferreira D, Zullo A, Ridola L, Malesci A. Safety of cold polypectomy for <10mm polyps at colonoscopy: a prospective multicenter study. Endoscopy. 2012 Jan;44(1):27-31. doi: 10.1055/s-0031-1291387. Epub 2011 Nov 28.
PMID: 22125197
responsible party type: Principal Investigator
investigator affiliation: San Diego Veterans Healthcare System
investigator full name: Dr. Mary Krinsky
investigator title: Clinical Professor of Medicine
mesh term: Polyps
mesh term: Colonic Polyps