<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02243982</url>
  </required_header>
  <id_info>
    <org_study_id>PI1080236</org_study_id>
    <nct_id>NCT02243982</nct_id>
  </id_info>
  <brief_title>Predictive and Diagnostic Value of Tau and Beta-amyloid Markers in the Dementia of Parkinson's Disease</brief_title>
  <official_title>Predictive and Diagnostic Value of Tau and Beta-amyloid Markers in Cerebrospinal Fluid and Positron Emission Tomography in the Dementia of Parkinson's Disease</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Fundacion Clinic per a la Recerca Biomédica</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Fundacion Clinic per a la Recerca Biomédica</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The PET tracer Fluoro-ethyl-methyl-amino-naphthyl-ethylidene-malononitrile ([F18]-FDDNP) has&#xD;
      a specific affinity for lesions containing tau protein and beta-amyloid The study consists of&#xD;
      two phases&#xD;
&#xD;
        -  In a first transversal phase, 8 neurologically unimpaired controls, 15 patients with PD&#xD;
           and no dementia (PDND) and 8 with PD and dementia (PDD) will undergo lumbar puncture for&#xD;
           study of tau, phospho-tau and beta-amyloid levels in cerebrospinal fluid (CSF), as well&#xD;
           as positron emission tomography (PET) with ([F18]-FDDNP. Concentration of CSF markers&#xD;
           and both the degree and topography of FDDNP-PET uptake will be compared among groups,&#xD;
           along with correlation analysis between CSF and PET findings.&#xD;
&#xD;
        -  During the second phase (18 months follow-up), the PDND patients will undergo the same&#xD;
           procedures, and cognitive changes including incident dementia will be assessed. The&#xD;
           correlation between cognitive impairment and neurochemical and neuroimaging changes will&#xD;
           be established to determine the predictive value of these markers.&#xD;
&#xD;
      Since the pathological lesions observed in Alzheimer disease (AD) are common in the PD and&#xD;
      the concentrations of tau and beta-amyloid are altered in AD and PET with [F18]-FDDNP is able&#xD;
      to separate patients with AD and cognitive impairment from controls, we hypothesized that:&#xD;
&#xD;
        1. - Patients with PD will show a biomarkers profile similar to the AD (decreased levels of&#xD;
           beta-amyloid and increased phospho-tau and tau) in CSF, and an abnormal uptake of&#xD;
           [F18]-FDDNP PET compared to PDND patients and controls.&#xD;
&#xD;
        2. -The distribution of cortical [F18]-FDDNP in the PD will be different from the AD and&#xD;
           similar to dementia with Lewy bodies, predominantly in posterior cortical areas.&#xD;
&#xD;
        3. PDND patients will show a [F18]-FDDNP PET uptake and levels of protein markers in CSF&#xD;
           intermediate between controls and patients with PD.&#xD;
&#xD;
        4. -In the subsequent follow-up, PDND patients will show cognitive impairment correlate to&#xD;
           changes in the levels of protein markers in CSF and uptake of PET with [F18]-FDDNP&#xD;
&#xD;
        5. - The predictive value for the development of dementia in PD of specific patterns of PET&#xD;
           uptake and CSF proteins profile will be established.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Completed</overall_status>
  <start_date>March 2010</start_date>
  <completion_date type="Actual">December 2012</completion_date>
  <primary_completion_date type="Actual">June 2011</primary_completion_date>
  <phase>Early Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>N/A</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <primary_purpose>Diagnostic</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Relative Volume of Distribution of [F18]-FDDNP in non-demented patients with Parkinson's disease (PDND), demented patients with Parkinson's disease (PDD) and controls.</measure>
    <time_frame>Baseline assessment</time_frame>
    <description>To asses the [F18]-FDDNP PET uptake in non-demented patients with Parkinson's disease (PDND), demented patients with Parkinson's disease (PDD) and controls.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Concentration ( pg/mL) of beta-amyloid, tau and phospho-tau in cerebrospinal fluid (CSF) of non-demented patients with Parkinson's disease (PDND), demented patients with Parkinson's disease (PDD) and controls.</measure>
    <time_frame>Baseline assessment</time_frame>
    <description>Enzyme linked immunosorbent assay (ELISA) method will be used to assess the concentration of the biomarkers in the CSF.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Number of patients without dementia at baseline that switch to dementia at 18 months follow-up</measure>
    <time_frame>18 months</time_frame>
    <description>PDND group will be followed-up at 18 months to assess the number of patient that develops dementia, using the criteria of Diagnostic and Statistical Manual of Mental Disorders version IV.</description>
  </secondary_outcome>
  <number_of_arms>1</number_of_arms>
  <enrollment type="Actual">28</enrollment>
  <condition>Parkinson's Disease</condition>
  <condition>Parkinson-Dementia Syndrome</condition>
  <arm_group>
    <arm_group_label>[F18]-FDDNP</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl)amino]-2-naphthyl}-ethylidene)malononitrile. Radiopharmaceutical tracer</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>[F18]-FDDNP</intervention_name>
    <description>radiopharmaceutical tracer, intravenous, single dose, of 360+/- 20 megabecquerel</description>
    <arm_group_label>[F18]-FDDNP</arm_group_label>
    <other_name>2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl)amino]-2-naphthyl}-ethylidene)malononitrile</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
        Inclusion Criteria PDD&#xD;
&#xD;
          -  Male or female ≥ 60 years old;&#xD;
&#xD;
          -  Diagnose of PD probable or definite according to criteria of the United Kingdom&#xD;
             Parkinson's Disease Society Brain Bank;&#xD;
&#xD;
          -  The Hoehn &amp; Yahr stage of the disease between 3 and 5 in off state;&#xD;
&#xD;
          -  Diagnose of dementia established according to the fourth edition of Diagnostic and&#xD;
             Statistical Manual of Mental Disorders (DSM-IV) and the diagnostic guidelines for&#xD;
             dementia of the Movement Disorders Society (MDS);&#xD;
&#xD;
          -  The score of the Mini-Mental State Examination of Folstein (MMSE) &lt;24;&#xD;
&#xD;
          -  The score on the Mattis Dementia Rating Scale (MDRS) &lt;136.&#xD;
&#xD;
        Inclusion criteria PDND:&#xD;
&#xD;
          -  Male or female ≥ 60 years old;&#xD;
&#xD;
          -  Diagnose of PD probable or definite according to criteria of the United Kingdom&#xD;
             Parkinson's Disease Society Brain Bank;&#xD;
&#xD;
          -  The Hoehn &amp; Yahr stage of the disease between 3 and 5 in OFF state;&#xD;
&#xD;
          -  The score of the Mini-Mental State Examination of Folstein (MMSE) ≥24;&#xD;
&#xD;
          -  The score on the Mattis Dementia Rating Scale (MDRS) ≥136.&#xD;
&#xD;
        Inclusion criteria Controls:&#xD;
&#xD;
          -  Male or female ≥ 60 years old;&#xD;
&#xD;
          -  No known diagnosis of neuropsychiatric diseases&#xD;
&#xD;
          -  The score of the Mini-Mental State Examination of Folstein (MMSE) ≥24;&#xD;
&#xD;
          -  The score on the Mattis Dementia Rating Scale (MDRS) ≥136.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  The subject is pregnant or breastfeeding;&#xD;
&#xD;
          -  The subject has a history of drug abuse or alcohol;&#xD;
&#xD;
          -  The subject has developed dementia in the first year of parkinsonism or before than&#xD;
             parkinsonism;&#xD;
&#xD;
          -  The subject meets criteria for vascular dementia;&#xD;
&#xD;
          -  The subject has symptoms suggestive of other types of parkinsonism (multi-system&#xD;
             atrophy cortico-basal, supra-nuclear palsy progressive degeneration) or degenerative&#xD;
             dementia (fronto-temporal dementia);&#xD;
&#xD;
          -  The subject has a moderate or severe renal functional impairment (serum creatinine&gt;&#xD;
             1.5 mg / dL);&#xD;
&#xD;
          -  The subject has a moderate or severe hepatic impairment (bilirubin&gt; 2 times the upper&#xD;
             limit of normal, transaminases&gt; 3 times the upper limit of normal);&#xD;
&#xD;
          -  The subject presents structural abnormalities in basal ganglia or cortical level on&#xD;
             magnetic resonance imaging or computerized tomography;&#xD;
&#xD;
          -  The subject has participated in a clinical study with an investigational drug product&#xD;
             within 30 days prior to screening and / or radiopharmaceutical in a minimum period of&#xD;
             5 radioactive half-lives prior to screening;&#xD;
&#xD;
          -  Occupational exposure to radiation&gt; 15 milliSievert (mSv) / year&#xD;
&#xD;
          -  The subject has received treatment with non-steroidal anti-inflammatory drugs during&#xD;
             the 30-day period before the PET scan&#xD;
&#xD;
          -  The subject has allergy to the investigational product or any of its components;&#xD;
&#xD;
          -  The subject has a clinically active, serious disease with a reduced life expectancy;&#xD;
&#xD;
          -  The subject is claustrophobic / a.&#xD;
&#xD;
          -  The subject has received in the last 364 days a dose of ionizing radiation that&#xD;
             coupled with the study dose exceeds 10 mSv&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>60 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Maria Jose Martí, Md, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Fundació per a la Recerca Biomedica</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Hospital Clinic</name>
      <address>
        <city>Barcelona</city>
        <zip>08036</zip>
        <country>Spain</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Spain</country>
  </location_countries>
  <reference>
    <citation>Caballol N, Marti MJ, Tolosa E. Cognitive dysfunction and dementia in Parkinson disease. Mov Disord. 2007 Sep;22 Suppl 17:S358-66. doi: 10.1002/mds.21677.</citation>
    <PMID>18175397</PMID>
  </reference>
  <reference>
    <citation>Aarsland D, Perry R, Brown A, Larsen JP, Ballard C. Neuropathology of dementia in Parkinson's disease: a prospective, community-based study. Ann Neurol. 2005 Nov;58(5):773-6. doi: 10.1002/ana.20635.</citation>
    <PMID>16240351</PMID>
  </reference>
  <reference>
    <citation>Lashley T, Holton JL, Gray E, Kirkham K, O'Sullivan SS, Hilbig A, Wood NW, Lees AJ, Revesz T. Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients. Acta Neuropathol. 2008 Apr;115(4):417-25. doi: 10.1007/s00401-007-0336-0. Epub 2008 Jan 8.</citation>
    <PMID>18185940</PMID>
  </reference>
  <reference>
    <citation>Jellinger KA, Wenning GK, Seppi K. Predictors of survival in dementia with lewy bodies and Parkinson dementia. Neurodegener Dis. 2007;4(6):428-30. doi: 10.1159/000107703. Epub 2007 Oct 9.</citation>
    <PMID>17934326</PMID>
  </reference>
  <reference>
    <citation>Blennow K, Hampel H. CSF markers for incipient Alzheimer's disease. Lancet Neurol. 2003 Oct;2(10):605-13. doi: 10.1016/s1474-4422(03)00530-1.</citation>
    <PMID>14505582</PMID>
  </reference>
  <reference>
    <citation>Jansen Steur E, Vermes I, de Vos RA. Cerebrospinal-fluid tau protein and aspartate aminotransferase in Parkinson's disease. Lancet. 1998 Apr 11;351(9109):1105-6. doi: 10.1016/s0140-6736(05)79387-9. No abstract available.</citation>
    <PMID>9660591</PMID>
  </reference>
  <reference>
    <citation>Mollenhauer B, Trenkwalder C, von Ahsen N, Bibl M, Steinacker P, Brechlin P, Schindehuette J, Poser S, Wiltfang J, Otto M. Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia. Dement Geriatr Cogn Disord. 2006;22(3):200-8. doi: 10.1159/000094871. Epub 2006 Aug 7.</citation>
    <PMID>16899997</PMID>
  </reference>
  <reference>
    <citation>Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, LaRossa GN, Spinner ML, Klunk WE, Mathis CA, DeKosky ST, Morris JC, Holtzman DM. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann Neurol. 2006 Mar;59(3):512-9. doi: 10.1002/ana.20730.</citation>
    <PMID>16372280</PMID>
  </reference>
  <reference>
    <citation>Maetzler W, Reimold M, Liepelt I, Solbach C, Leyhe T, Schweitzer K, Eschweiler GW, Mittelbronn M, Gaenslen A, Uebele M, Reischl G, Gasser T, Machulla HJ, Bares R, Berg D. [11C]PIB binding in Parkinson's disease dementia. Neuroimage. 2008 Feb 1;39(3):1027-33. doi: 10.1016/j.neuroimage.2007.09.072. Epub 2007 Oct 22.</citation>
    <PMID>18035558</PMID>
  </reference>
  <reference>
    <citation>Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, Cole GM, Small GW, Huang SC, Barrio JR. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci. 2001 Dec 15;21(24):RC189. doi: 10.1523/JNEUROSCI.21-24-j0004.2001.</citation>
    <PMID>11734604</PMID>
  </reference>
  <reference>
    <citation>Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, Read S, Satyamurthy N, Petric A, Huang SC, Barrio JR. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry. 2002 Jan-Feb;10(1):24-35.</citation>
    <PMID>11790632</PMID>
  </reference>
  <reference>
    <citation>Smid LM, Vovko TD, Popovic M, Petric A, Kepe V, Barrio JR, Vidmar G, Bresjanac M. The 2,6-disubstituted naphthalene derivative FDDNP labeling reliably predicts Congo red birefringence of protein deposits in brain sections of selected human neurodegenerative diseases. Brain Pathol. 2006 Apr;16(2):124-30. doi: 10.1111/j.1750-3639.2006.00006.x.</citation>
    <PMID>16768752</PMID>
  </reference>
  <reference>
    <citation>Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang SC, Satyamurthy N, Phelps ME, Barrio JR. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med. 2006 Dec 21;355(25):2652-63. doi: 10.1056/NEJMoa054625.</citation>
    <PMID>17182990</PMID>
  </reference>
  <reference>
    <citation>Kepe V, Huang SC, Small GW, Satyamurthy N, Barrio JR. Visualizing pathology deposits in the living brain of patients with Alzheimer's disease. Methods Enzymol. 2006;412:144-60. doi: 10.1016/S0076-6879(06)12010-8.</citation>
    <PMID>17046657</PMID>
  </reference>
  <reference>
    <citation>Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab. 1996 Sep;16(5):834-40. doi: 10.1097/00004647-199609000-00008.</citation>
    <PMID>8784228</PMID>
  </reference>
  <verification_date>December 2009</verification_date>
  <study_first_submitted>August 13, 2014</study_first_submitted>
  <study_first_submitted_qc>September 16, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 18, 2014</study_first_posted>
  <last_update_submitted>September 16, 2014</last_update_submitted>
  <last_update_submitted_qc>September 16, 2014</last_update_submitted_qc>
  <last_update_posted type="Estimate">September 18, 2014</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Fundacion Clinic per a la Recerca Biomédica</investigator_affiliation>
    <investigator_full_name>Maria Jose Martí</investigator_full_name>
    <investigator_title>MD, PhD</investigator_title>
  </responsible_party>
  <keyword>Parkinson, dementia, FDDNP, tau, beta-amyloid</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Parkinson Disease</mesh_term>
    <mesh_term>Dementia</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02243982
org study id: PI1080236
nct id: NCT02243982
lead sponsor: 
has dmc: No
The PET tracer Fluoro-ethyl-methyl-amino-naphthyl-ethylidene-malononitrile ([F18]-FDDNP) has
      a specific affinity for lesions containing tau protein and beta-amyloid The study consists of
      two phases

        -  In a first transversal phase, 8 neurologically unimpaired controls, 15 patients with PD
           and no dementia (PDND) and 8 with PD and dementia (PDD) will undergo lumbar puncture for
           study of tau, phospho-tau and beta-amyloid levels in cerebrospinal fluid (CSF), as well
           as positron emission tomography (PET) with ([F18]-FDDNP. Concentration of CSF markers
           and both the degree and topography of FDDNP-PET uptake will be compared among groups,
           along with correlation analysis between CSF and PET findings.

        -  During the second phase (18 months follow-up), the PDND patients will undergo the same
           procedures, and cognitive changes including incident dementia will be assessed. The
           correlation between cognitive impairment and neurochemical and neuroimaging changes will
           be established to determine the predictive value of these markers.

      Since the pathological lesions observed in Alzheimer disease (AD) are common in the PD and
      the concentrations of tau and beta-amyloid are altered in AD and PET with [F18]-FDDNP is able
      to separate patients with AD and cognitive impairment from controls, we hypothesized that:

        1. - Patients with PD will show a biomarkers profile similar to the AD (decreased levels of
           beta-amyloid and increased phospho-tau and tau) in CSF, and an abnormal uptake of
           [F18]-FDDNP PET compared to PDND patients and controls.

        2. -The distribution of cortical [F18]-FDDNP in the PD will be different from the AD and
           similar to dementia with Lewy bodies, predominantly in posterior cortical areas.

        3. PDND patients will show a [F18]-FDDNP PET uptake and levels of protein markers in CSF
           intermediate between controls and patients with PD.

        4. -In the subsequent follow-up, PDND patients will show cognitive impairment correlate to
           changes in the levels of protein markers in CSF and uptake of PET with [F18]-FDDNP

        5. - The predictive value for the development of dementia in PD of specific patterns of PET
           uptake and CSF proteins profile will be established.
allocation: N/A
intervention model: Single Group Assignment
primary purpose: Diagnostic
masking: None (Open Label)
measure: Relative Volume of Distribution of [F18]-FDDNP in non-demented patients with Parkinson's disease (PDND), demented patients with Parkinson's disease (PDD) and controls.
time frame: Baseline assessment
description: To asses the [F18]-FDDNP PET uptake in non-demented patients with Parkinson's disease (PDND), demented patients with Parkinson's disease (PDD) and controls.
measure: Concentration ( pg/mL) of beta-amyloid, tau and phospho-tau in cerebrospinal fluid (CSF) of non-demented patients with Parkinson's disease (PDND), demented patients with Parkinson's disease (PDD) and controls.
time frame: Baseline assessment
description: Enzyme linked immunosorbent assay (ELISA) method will be used to assess the concentration of the biomarkers in the CSF.
measure: Number of patients without dementia at baseline that switch to dementia at 18 months follow-up
time frame: 18 months
description: PDND group will be followed-up at 18 months to assess the number of patient that develops dementia, using the criteria of Diagnostic and Statistical Manual of Mental Disorders version IV.
arm group label: [F18]-FDDNP
arm group type: Experimental
description: 2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl)amino]-2-naphthyl}-ethylidene)malononitrile. Radiopharmaceutical tracer
intervention type: Other
intervention name: [F18]-FDDNP
description: radiopharmaceutical tracer, intravenous, single dose, of 360+/- 20 megabecquerel
arm group label: [F18]-FDDNP
other name: 2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl)amino]-2-naphthyl}-ethylidene)malononitrile
criteria: 
gender: All
minimum age: 60 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
last name: Maria Jose Martí, Md, PhD
role: Principal Investigator
affiliation: Fundació per a la Recerca Biomedica
facility: 
country: Spain
citation: Caballol N, Marti MJ, Tolosa E. Cognitive dysfunction and dementia in Parkinson disease. Mov Disord. 2007 Sep;22 Suppl 17:S358-66. doi: 10.1002/mds.21677.
PMID: 18175397
citation: Aarsland D, Perry R, Brown A, Larsen JP, Ballard C. Neuropathology of dementia in Parkinson's disease: a prospective, community-based study. Ann Neurol. 2005 Nov;58(5):773-6. doi: 10.1002/ana.20635.
PMID: 16240351
citation: Lashley T, Holton JL, Gray E, Kirkham K, O'Sullivan SS, Hilbig A, Wood NW, Lees AJ, Revesz T. Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients. Acta Neuropathol. 2008 Apr;115(4):417-25. doi: 10.1007/s00401-007-0336-0. Epub 2008 Jan 8.
PMID: 18185940
citation: Jellinger KA, Wenning GK, Seppi K. Predictors of survival in dementia with lewy bodies and Parkinson dementia. Neurodegener Dis. 2007;4(6):428-30. doi: 10.1159/000107703. Epub 2007 Oct 9.
PMID: 17934326
citation: Blennow K, Hampel H. CSF markers for incipient Alzheimer's disease. Lancet Neurol. 2003 Oct;2(10):605-13. doi: 10.1016/s1474-4422(03)00530-1.
PMID: 14505582
citation: Jansen Steur E, Vermes I, de Vos RA. Cerebrospinal-fluid tau protein and aspartate aminotransferase in Parkinson's disease. Lancet. 1998 Apr 11;351(9109):1105-6. doi: 10.1016/s0140-6736(05)79387-9. No abstract available.
PMID: 9660591
citation: Mollenhauer B, Trenkwalder C, von Ahsen N, Bibl M, Steinacker P, Brechlin P, Schindehuette J, Poser S, Wiltfang J, Otto M. Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia. Dement Geriatr Cogn Disord. 2006;22(3):200-8. doi: 10.1159/000094871. Epub 2006 Aug 7.
PMID: 16899997
citation: Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, LaRossa GN, Spinner ML, Klunk WE, Mathis CA, DeKosky ST, Morris JC, Holtzman DM. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann Neurol. 2006 Mar;59(3):512-9. doi: 10.1002/ana.20730.
PMID: 16372280
citation: Maetzler W, Reimold M, Liepelt I, Solbach C, Leyhe T, Schweitzer K, Eschweiler GW, Mittelbronn M, Gaenslen A, Uebele M, Reischl G, Gasser T, Machulla HJ, Bares R, Berg D. [11C]PIB binding in Parkinson's disease dementia. Neuroimage. 2008 Feb 1;39(3):1027-33. doi: 10.1016/j.neuroimage.2007.09.072. Epub 2007 Oct 22.
PMID: 18035558
citation: Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, Cole GM, Small GW, Huang SC, Barrio JR. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci. 2001 Dec 15;21(24):RC189. doi: 10.1523/JNEUROSCI.21-24-j0004.2001.
PMID: 11734604
citation: Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, Read S, Satyamurthy N, Petric A, Huang SC, Barrio JR. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry. 2002 Jan-Feb;10(1):24-35.
PMID: 11790632
citation: Smid LM, Vovko TD, Popovic M, Petric A, Kepe V, Barrio JR, Vidmar G, Bresjanac M. The 2,6-disubstituted naphthalene derivative FDDNP labeling reliably predicts Congo red birefringence of protein deposits in brain sections of selected human neurodegenerative diseases. Brain Pathol. 2006 Apr;16(2):124-30. doi: 10.1111/j.1750-3639.2006.00006.x.
PMID: 16768752
citation: Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang SC, Satyamurthy N, Phelps ME, Barrio JR. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med. 2006 Dec 21;355(25):2652-63. doi: 10.1056/NEJMoa054625.
PMID: 17182990
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PMID: 8784228
responsible party type: Principal Investigator
investigator affiliation: Fundacion Clinic per a la Recerca Biomédica
investigator full name: Maria Jose Martí
investigator title: MD, PhD
mesh term: Parkinson Disease
mesh term: Dementia