<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02248103</url>
  </required_header>
  <id_info>
    <org_study_id>MPP graft_GTR</org_study_id>
    <nct_id>NCT02248103</nct_id>
  </id_info>
  <brief_title>Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects</brief_title>
  <official_title>Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects: A Randomized Controlled Clinical Trial.</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Cairo University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Cairo University</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison&#xD;
      with collagen membrane for management of periodontal intrabony defects.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Twenty patients suffering from advanced chronic periodontitis were included in this&#xD;
      randomized controlled clinical trial. Each subject contributed matched pairs of two- or&#xD;
      three-walled intrabony defects. Each pair of periodontal defects were randomly assigned into&#xD;
      the experimental group; periosteal pedicle graft guided tissue membrane or the positive&#xD;
      control group; bioresorbable collagen guided tissue regeneration membrane. Clinical and&#xD;
      radiographic parameters were recorded at baseline and at 6 months postoperatively.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date>March 2013</start_date>
  <completion_date type="Actual">May 2014</completion_date>
  <primary_completion_date type="Actual">April 2014</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Participant)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Clinical Attachment Level</measure>
    <time_frame>Baseline and 6 months</time_frame>
    <description>Estimation of clinical attachment level in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Pocket Depth</measure>
    <time_frame>Baseline and 6 months</time_frame>
    <description>Estimation of pocket depth in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Bone Defect Area</measure>
    <time_frame>Baseline and 6 months</time_frame>
    <description>linear measurements collected from a digital radiography program to estimate percentage of defect fill.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">20</enrollment>
  <condition>Chronic Periodontitis</condition>
  <arm_group>
    <arm_group_label>periosteal pedicle graft</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>autogenous marginal periosteal pedicle graft harvested by partial thickness periodontal flap.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Bioresorbable collagen membrane</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Equine Achilles tendon collagen barrier membrane</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>Periosteal pedicle graft</intervention_name>
    <description>Autogenous pedicle graft harvested from the periosteum</description>
    <arm_group_label>periosteal pedicle graft</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Biological</intervention_type>
    <intervention_name>Bioresorbable collagen membrane</intervention_name>
    <description>Biocollagen is a thin equine Achilles tendon collagen barrier membrane used for guided tissue regeneration</description>
    <arm_group_label>Bioresorbable collagen membrane</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Severe chronic periodontitis patients with at least two sites with pocket depth ≥ 6 mm&#xD;
             and clinical attachment level ≥ 5 mm, with radiographic evidence of bone loss 2- or&#xD;
             3-wall intrabony defect depth ranging from 3 to 6 mm as detected in periapical&#xD;
             radiographs&#xD;
&#xD;
          -  The facial surface of teeth adjacent to the interproximal defect should be free of&#xD;
             extensive recession and marginal bone loss, with at least a 4 to 5 mm band of&#xD;
             keratinized gingiva to allow for periosteal manipulation&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Pregnant women&#xD;
&#xD;
          -  Subjects had &lt;22 permanent teeth&#xD;
&#xD;
          -  Having any given systemic disease&#xD;
&#xD;
          -  Taking any type of medication and/or antibiotic therapy during the 3 months before the&#xD;
             study&#xD;
&#xD;
          -  Received periodontal treatment within the past 12 months&#xD;
&#xD;
          -  Current or former smokers&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>35 Years</minimum_age>
    <maximum_age>50 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Noha Ghallab, M.D.</last_name>
    <role>Principal Investigator</role>
    <affiliation>Associate Professor of periodontology faulty of oral and dental medicine Cairo Unv.</affiliation>
  </overall_official>
  <results_reference>
    <citation>Singhal R, Nandlal, Kumar A, Rastogi P. Role of space provision in regeneration of localized two-wall intrabony defects using periosteal pedicle graft as an autogenous guided tissue membrane. J Periodontol. 2013 Mar;84(3):316-24. doi: 10.1902/jop.2012.110734. Epub 2012 May 21.</citation>
    <PMID>22612365</PMID>
  </results_reference>
  <results_reference>
    <citation>Gamal AY, Mailhot JM. A novel marginal periosteal pedicle graft as an autogenous guided tissue membrane for the treatment of intrabony periodontal defects. J Int Acad Periodontol. 2008 Oct;10(4):106-17.</citation>
    <PMID>19055224</PMID>
  </results_reference>
  <results_reference>
    <citation>Paolantonio M, Femminella B, Coppolino E, Sammartino G, D'Arcangelo C, Perfetti G, Perinetti G. Autogenous periosteal barrier membranes and bone grafts in the treatment of periodontal intrabony defects of single-rooted teeth: a 12-month reentry randomized controlled clinical trial. J Periodontol. 2010 Nov;81(11):1587-95. doi: 10.1902/jop.2010.100094. Epub 2010 Jun 28.</citation>
    <PMID>20583915</PMID>
  </results_reference>
  <results_reference>
    <citation>Bunyaratavej P, Wang HL. Collagen membranes: a review. J Periodontol. 2001 Feb;72(2):215-29. doi: 10.1902/jop.2001.72.2.215.</citation>
    <PMID>11288796</PMID>
  </results_reference>
  <results_reference>
    <citation>Stoecklin-Wasmer C, Rutjes AW, da Costa BR, Salvi GE, Juni P, Sculean A. Absorbable collagen membranes for periodontal regeneration: a systematic review. J Dent Res. 2013 Sep;92(9):773-81. doi: 10.1177/0022034513496428. Epub 2013 Jul 10.</citation>
    <PMID>23842107</PMID>
  </results_reference>
  <verification_date>April 2017</verification_date>
  <study_first_submitted>September 20, 2014</study_first_submitted>
  <study_first_submitted_qc>September 23, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 25, 2014</study_first_posted>
  <results_first_submitted>August 10, 2015</results_first_submitted>
  <results_first_submitted_qc>September 8, 2015</results_first_submitted_qc>
  <results_first_posted type="Estimate">October 9, 2015</results_first_posted>
  <last_update_submitted>April 21, 2017</last_update_submitted>
  <last_update_submitted_qc>April 21, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">April 24, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Cairo University</investigator_affiliation>
    <investigator_full_name>Noha Ayman Ghallab</investigator_full_name>
    <investigator_title>Associate Professor of periodontology, faculty of oral and dental medicine</investigator_title>
  </responsible_party>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Periodontitis</mesh_term>
    <mesh_term>Chronic Periodontitis</mesh_term>
  </condition_browse>

  <clinical_results>

    <participant_flow>
      <group_list>
        <group group_id="P1">
          <title>Periosteal Pedicle Graft</title>
          <description>autogenous marginal periosteal pedicle graft harvested by partial thickness periodontal flap.&#xD;
Periosteal pedicle graft: Autogenous pedicle graft harvested from the periosteum</description>
        </group>
        <group group_id="P2">
          <title>Bioresorbable Collagen Membrane</title>
          <description>Equine Achilles tendon collagen barrier membrane&#xD;
Bioresorbable collagen membrane: Biocollagen is a thin equine Achilles tendon collagen barrier membrane used for guided tissue regeneration</description>
        </group>
      </group_list>
      <period_list>
        <period>
          <title>Overall Study</title>
          <milestone_list>
            <milestone>
              <title>STARTED</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
                <participants group_id="P2" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
                <participants group_id="P2" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>NOT COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="0"/>
                <participants group_id="P2" count="0"/>
              </participants_list>
            </milestone>
          </milestone_list>
        </period>
      </period_list>
    </participant_flow>

    <baseline>
      <group_list>
        <group group_id="B1">
          <title>Periosteal Pedicle Graft</title>
          <description>autogenous marginal periosteal pedicle graft harvested by partial thickness periodontal flap.&#xD;
Periosteal pedicle graft: Autogenous pedicle graft harvested from the periosteum</description>
        </group>
        <group group_id="B2">
          <title>Bioresorbable Collagen Membrane</title>
          <description>Equine Achilles tendon collagen barrier membrane&#xD;
Bioresorbable collagen membrane: Biocollagen is a thin equine Achilles tendon collagen barrier membrane used for guided tissue regeneration</description>
        </group>
        <group group_id="B3">
          <title>Total</title>
          <description>Total of all reporting groups</description>
        </group>
      </group_list>
      <analyzed_list>
        <analyzed>
          <units>Participants</units>
          <scope>Overall</scope>
          <count_list>
            <count group_id="B1" value="10"/>
            <count group_id="B2" value="10"/>
            <count group_id="B3" value="20"/>
          </count_list>
        </analyzed>
      </analyzed_list>
      <measure_list>
        <measure>
          <title>Age</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>&lt;=18 years</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Between 18 and 65 years</title>
                  <measurement_list>
                    <measurement group_id="B1" value="10"/>
                    <measurement group_id="B2" value="10"/>
                    <measurement group_id="B3" value="20"/>
                  </measurement_list>
                </category>
                <category>
                  <title>&gt;=65 years</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                    <measurement group_id="B2" value="0"/>
                    <measurement group_id="B3" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Age</title>
          <units>years</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="37.81" spread="8.3"/>
                    <measurement group_id="B2" value="37.81" spread="8.3"/>
                    <measurement group_id="B3" value="37.81" spread="8.3"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Sex: Female, Male</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>Female</title>
                  <measurement_list>
                    <measurement group_id="B1" value="5"/>
                    <measurement group_id="B2" value="5"/>
                    <measurement group_id="B3" value="10"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Male</title>
                  <measurement_list>
                    <measurement group_id="B1" value="5"/>
                    <measurement group_id="B2" value="5"/>
                    <measurement group_id="B3" value="10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </measure_list>
    </baseline>

    <outcome_list>
      <outcome>
        <type>Primary</type>
        <title>Clinical Attachment Level</title>
        <description>Estimation of clinical attachment level in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration</description>
        <time_frame>Baseline and 6 months</time_frame>
        <population>defects</population>
        <group_list>
          <group group_id="O1">
            <title>Periosteal Pedicle Graft</title>
            <description>autogenous marginal periosteal pedicle graft harvested by partial thickness periodontal flap.&#xD;
Periosteal pedicle graft: Autogenous pedicle graft harvested from the periosteum</description>
          </group>
          <group group_id="O2">
            <title>Bioresorbable Collagen Membrane</title>
            <description>Equine Achilles tendon collagen barrier membrane&#xD;
Bioresorbable collagen membrane: Biocollagen is a thin equine Achilles tendon collagen barrier membrane used for guided tissue regeneration</description>
          </group>
        </group_list>
        <measure>
          <title>Clinical Attachment Level</title>
          <description>Estimation of clinical attachment level in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration</description>
          <population>defects</population>
          <units>mm</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
                <count group_id="O2" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Baseline CAL</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.42" spread="0.56"/>
                    <measurement group_id="O2" value="6.15" spread="0.98"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>CAL after 6 months</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.52" spread="0.44"/>
                    <measurement group_id="O2" value="3.6" spread="0.57"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Pocket Depth</title>
        <description>Estimation of pocket depth in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration</description>
        <time_frame>Baseline and 6 months</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Periosteal Pedicle Graft</title>
            <description>autogenous marginal periosteal pedicle graft harvested by partial thickness periodontal flap.&#xD;
Periosteal pedicle graft: Autogenous pedicle graft harvested from the periosteum</description>
          </group>
          <group group_id="O2">
            <title>Bioresorbable Collagen Membrane</title>
            <description>Equine Achilles tendon collagen barrier membrane&#xD;
Bioresorbable collagen membrane: Biocollagen is a thin equine Achilles tendon collagen barrier membrane used for guided tissue regeneration</description>
          </group>
        </group_list>
        <measure>
          <title>Pocket Depth</title>
          <description>Estimation of pocket depth in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration</description>
          <units>mm</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
                <count group_id="O2" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Baseline PD</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.92" spread="0.76"/>
                    <measurement group_id="O2" value="6.82" spread="1.1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>PD after 6 months</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.17" spread="0.65"/>
                    <measurement group_id="O2" value="3.15" spread="0.67"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Bone Defect Area</title>
        <description>linear measurements collected from a digital radiography program to estimate percentage of defect fill.</description>
        <time_frame>Baseline and 6 months</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Periosteal Pedicle Graft</title>
            <description>autogenous marginal periosteal pedicle graft harvested by partial thickness periodontal flap.&#xD;
Periosteal pedicle graft: Autogenous pedicle graft harvested from the periosteum</description>
          </group>
          <group group_id="O2">
            <title>Bioresorbable Collagen Membrane</title>
            <description>Equine Achilles tendon collagen barrier membrane&#xD;
Bioresorbable collagen membrane: Biocollagen is a thin equine Achilles tendon collagen barrier membrane used for guided tissue regeneration</description>
          </group>
        </group_list>
        <measure>
          <title>Bone Defect Area</title>
          <description>linear measurements collected from a digital radiography program to estimate percentage of defect fill.</description>
          <units>&quot;mm^2&quot;</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
                <count group_id="O2" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>Baseline bone defect area</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.37" spread="4.13"/>
                    <measurement group_id="O2" value="9.25" spread="3.23"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>Bone defect area after 6 months</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.42" spread="0.72"/>
                    <measurement group_id="O2" value="5.7" spread="2.99"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
    </outcome_list>

    <reported_events>
      <time_frame>6 months</time_frame>
      <group_list>
        <group group_id="E1">
          <title>Periosteal Pedicle Graft</title>
          <description>autogenous marginal periosteal pedicle graft harvested by partial thickness periodontal flap.&#xD;
Periosteal pedicle graft: Autogenous pedicle graft harvested from the periosteum</description>
        </group>
        <group group_id="E2">
          <title>Bioresorbable Collagen Membrane</title>
          <description>Equine Achilles tendon collagen barrier membrane&#xD;
Bioresorbable collagen membrane: Biocollagen is a thin equine Achilles tendon collagen barrier membrane used for guided tissue regeneration</description>
        </group>
      </group_list>
      <serious_events>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, serious adverse events</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="10"/>
                <counts group_id="E2" subjects_affected="0" subjects_at_risk="10"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </serious_events>
      <other_events>
        <frequency_threshold>0</frequency_threshold>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, other adverse events</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="10"/>
                <counts group_id="E2" subjects_affected="0" subjects_at_risk="10"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </other_events>
    </reported_events>

    <certain_agreements>
      <pi_employee>Principal Investigators are NOT employed by the organization sponsoring the study.</pi_employee>
      <restrictive_agreement>There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed. </restrictive_agreement>
    </certain_agreements>
    <point_of_contact>
      <name_or_title>Ass. Prof. Dr. Noha Ghallab</name_or_title>
      <organization>Faculty of Oral and Dental Medicine Cairo University</organization>
      <phone>+201005263365</phone>
      <email>noha.ghallab@dentistry.cu.edu.eg</email>
    </point_of_contact>
  </clinical_results>
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02248103
org study id: MPP graft_GTR
nct id: NCT02248103
lead sponsor: 
has dmc: No
A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison
      with collagen membrane for management of periodontal intrabony defects.
Twenty patients suffering from advanced chronic periodontitis were included in this
      randomized controlled clinical trial. Each subject contributed matched pairs of two- or
      three-walled intrabony defects. Each pair of periodontal defects were randomly assigned into
      the experimental group; periosteal pedicle graft guided tissue membrane or the positive
      control group; bioresorbable collagen guided tissue regeneration membrane. Clinical and
      radiographic parameters were recorded at baseline and at 6 months postoperatively.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Single (Participant)
measure: Clinical Attachment Level
time frame: Baseline and 6 months
description: Estimation of clinical attachment level in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration
measure: Pocket Depth
time frame: Baseline and 6 months
description: Estimation of pocket depth in chronic periodontitis patients at baseline and 6 months after guided tissue regeneration
measure: Bone Defect Area
time frame: Baseline and 6 months
description: linear measurements collected from a digital radiography program to estimate percentage of defect fill.
arm group label: periosteal pedicle graft
arm group type: Experimental
description: autogenous marginal periosteal pedicle graft harvested by partial thickness periodontal flap.
arm group label: Bioresorbable collagen membrane
arm group type: Active Comparator
description: Equine Achilles tendon collagen barrier membrane
intervention type: Procedure
intervention name: Periosteal pedicle graft
description: Autogenous pedicle graft harvested from the periosteum
arm group label: periosteal pedicle graft
intervention type: Biological
intervention name: Bioresorbable collagen membrane
description: Biocollagen is a thin equine Achilles tendon collagen barrier membrane used for guided tissue regeneration
arm group label: Bioresorbable collagen membrane
criteria: 
gender: All
minimum age: 35 Years
maximum age: 50 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Noha Ghallab, M.D.
role: Principal Investigator
affiliation: Associate Professor of periodontology faulty of oral and dental medicine Cairo Unv.
citation: Singhal R, Nandlal, Kumar A, Rastogi P. Role of space provision in regeneration of localized two-wall intrabony defects using periosteal pedicle graft as an autogenous guided tissue membrane. J Periodontol. 2013 Mar;84(3):316-24. doi: 10.1902/jop.2012.110734. Epub 2012 May 21.
PMID: 22612365
citation: Gamal AY, Mailhot JM. A novel marginal periosteal pedicle graft as an autogenous guided tissue membrane for the treatment of intrabony periodontal defects. J Int Acad Periodontol. 2008 Oct;10(4):106-17.
PMID: 19055224
citation: Paolantonio M, Femminella B, Coppolino E, Sammartino G, D'Arcangelo C, Perfetti G, Perinetti G. Autogenous periosteal barrier membranes and bone grafts in the treatment of periodontal intrabony defects of single-rooted teeth: a 12-month reentry randomized controlled clinical trial. J Periodontol. 2010 Nov;81(11):1587-95. doi: 10.1902/jop.2010.100094. Epub 2010 Jun 28.
PMID: 20583915
citation: Bunyaratavej P, Wang HL. Collagen membranes: a review. J Periodontol. 2001 Feb;72(2):215-29. doi: 10.1902/jop.2001.72.2.215.
PMID: 11288796
citation: Stoecklin-Wasmer C, Rutjes AW, da Costa BR, Salvi GE, Juni P, Sculean A. Absorbable collagen membranes for periodontal regeneration: a systematic review. J Dent Res. 2013 Sep;92(9):773-81. doi: 10.1177/0022034513496428. Epub 2013 Jul 10.
PMID: 23842107
responsible party type: Principal Investigator
investigator affiliation: Cairo University
investigator full name: Noha Ayman Ghallab
investigator title: Associate Professor of periodontology, faculty of oral and dental medicine
mesh term: Periodontitis
mesh term: Chronic Periodontitis
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