<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT02233647</url>
  </required_header>
  <id_info>
    <org_study_id>BED (IN) 29</org_study_id>
    <nct_id>NCT02233647</nct_id>
  </id_info>
  <brief_title>Phendimetrazine and Cocaine</brief_title>
  <official_title>Safety and Tolerability of Cocaine During Phendimetrazine Maintenance</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>William Stoops</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
    <collaborator>
      <agency>National Institute on Drug Abuse (NIDA)</agency>
      <agency_class>NIH</agency_class>
    </collaborator>
  </sponsors>
  <source>University of Kentucky</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a&#xD;
      pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will&#xD;
      be conducted in which the subjective and physiological effects of cocaine are evaluated&#xD;
      during maintenance on placebo and phendimetrazine.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Completed</overall_status>
  <start_date>September 2014</start_date>
  <completion_date type="Actual">December 2015</completion_date>
  <primary_completion_date type="Actual">December 2015</primary_completion_date>
  <phase>Early Phase 1</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Non-Randomized</allocation>
    <intervention_model>Crossover Assignment</intervention_model>
    <primary_purpose>Basic Science</primary_purpose>
    <masking>Triple (Participant, Care Provider, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Peak Systolic Pressure</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Systolic blood pressure was measured with an automated monitor. Higher values represent greater systolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Peak Diastolic Pressure</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Diastolic blood pressure was measured with an automated monitor. Higher values represent greater diastolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Peak Heart Rate</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Heart rate was measured with an automated monitor. Higher values represent greater heart rate. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
  </primary_outcome>
  <primary_outcome>
    <measure>Peak Temperature</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Oral temperature was measured with an automated monitor. Higher values represent greater temperature. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Peak Score on Sedative Subscale of the Adjective Rating Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects completed 16 items that loaded into the Sedative Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 &quot;sedative&quot; items was summed to yield the Sedative Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Score on Stimulant Subscale of the Adjective Rating Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects completed 16 items that loaded into the Stimulant Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 &quot;stimulant&quot; items was summed to yield the Stimulant Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Active, Alert, Energetic&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Active, Alert, Energetic&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Any Effect&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Any Effect&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Bad Effect&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Bad Effect&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Euphoric&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Euphoric&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Good Effect&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Good Effect&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;High&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;High&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Irregular/Racing Heartbeat&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Irregular/Racing Heartbeat&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Like Drug&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Like Drug&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Nauseated/Queasy/Sick to Stomach&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Nauseated/Queasy/Sick to Stomach&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Nervous/Anxious&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Nervous/Anxious&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Willing to Pay For&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Willing to Pay For&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Performance Impaired&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Performance Impaired&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Performance Improved&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Performance Improved&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Restless&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Restless&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Rush&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Rush&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Shaky/Jittery&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Shaky/Jittery&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Sluggish/Fatigued/Lazy&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Sluggish/Fatigued/Lazy&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Stimulated&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Stimulated&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Willing to Take Again&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Willing to Take Again&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Peak Ratings of &quot;Talkative/Friendly&quot; on the Visual Analog Scale</measure>
    <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
    <description>Subjects rated their feelings of &quot;Talkative/Friendly&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
  </secondary_outcome>
  <number_of_arms>4</number_of_arms>
  <enrollment type="Actual">11</enrollment>
  <condition>Cocaine Use Disorder</condition>
  <arm_group>
    <arm_group_label>Placebo</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>Subjects will be maintained on oral placebo. Cocaine will be administered acutely during placebo maintenance. Placebo will be administered acutely during placebo maintenance.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Phendimetrazine Dose 1</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Subjects will be maintained on the low phendimetrazine dose. Cocaine will be administered acutely during low dose phendimetrazine maintenance.&#xD;
Placebo will be administered acutely during low dose phendimetrazine maintenance.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Phendimetrazine Dose 2</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Subjects will be maintained on the intermediate phendimetrazine dose. Cocaine will be administered acutely during intermediate dose phendimetrazine maintenance.&#xD;
Placebo will be administered acutely during intermediate dose phendimetrazine maintenance.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Phendimetrazine Dose 3</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Subjects will be maintained on the high phendimetrazine dose. Cocaine will be administered acutely during high dose phendimetrazine maintenance.&#xD;
Placebo will be administered acutely during high dose phendimetrazine maintenance.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Cocaine</intervention_name>
    <description>The pharmacodynamic effects of cocaine will be determined during maintenance on placebo and phendimetrazine.</description>
    <arm_group_label>Phendimetrazine Dose 1</arm_group_label>
    <arm_group_label>Phendimetrazine Dose 2</arm_group_label>
    <arm_group_label>Phendimetrazine Dose 3</arm_group_label>
    <arm_group_label>Placebo</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Placebo</intervention_name>
    <description>The pharmacodynamic effects of placebo will be determined during maintenance on placebo and phendimetrazine.</description>
    <arm_group_label>Phendimetrazine Dose 1</arm_group_label>
    <arm_group_label>Phendimetrazine Dose 2</arm_group_label>
    <arm_group_label>Phendimetrazine Dose 3</arm_group_label>
    <arm_group_label>Placebo</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Recent cocaine use&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians&#xD;
             deem clinically significant&#xD;
&#xD;
          -  Current or past histories of substance abuse or dependence that are deemed by the&#xD;
             study physicians to interfere with study completion&#xD;
&#xD;
          -  History of serious physical disease, current physical disease, impaired cardiovascular&#xD;
             functioning, chronic obstructive pulmonary disease, history of seizure or current or&#xD;
             past histories of serious psychiatric disorder that in the opinion of the study&#xD;
             physician would interfere with study participation will be excluded from participation&#xD;
&#xD;
          -  Females not currently using effective birth control&#xD;
&#xD;
          -  Contraindications to cocaine or phendimetrazine&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>55 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>William W Stoops, Ph.D.</last_name>
    <role>Principal Investigator</role>
    <affiliation>University of Kentucky</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>University of Kentucky Laboratory of Human Behavioral Pharmacology</name>
      <address>
        <city>Lexington</city>
        <state>Kentucky</state>
        <zip>40507</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <verification_date>September 2017</verification_date>
  <study_first_submitted>September 3, 2014</study_first_submitted>
  <study_first_submitted_qc>September 5, 2014</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 8, 2014</study_first_posted>
  <results_first_submitted>July 26, 2016</results_first_submitted>
  <results_first_submitted_qc>July 26, 2016</results_first_submitted_qc>
  <results_first_posted type="Estimate">September 15, 2016</results_first_posted>
  <last_update_submitted>September 26, 2017</last_update_submitted>
  <last_update_submitted_qc>September 26, 2017</last_update_submitted_qc>
  <last_update_posted type="Actual">September 27, 2017</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>University of Kentucky</investigator_affiliation>
    <investigator_full_name>William Stoops</investigator_full_name>
    <investigator_title>Associate Professor</investigator_title>
  </responsible_party>
  <keyword>cocaine</keyword>
  <keyword>phendimetrazine</keyword>
  <keyword>pharmacotherapy</keyword>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Cocaine</mesh_term>
  </intervention_browse>

  <clinical_results>

    <participant_flow>
      <pre_assignment_details>Eleven subjects were enrolled (i.e., signed consent), but only 10 subjects completed. Due to the within-subject nature of this study (i.e., missing data from the 11th subject cannot be analyzed with repeated-measures ANOVA), only data from the 10 subjects who completed the protocol were analyzed and reported.</pre_assignment_details>
      <group_list>
        <group group_id="P1">
          <title>Phendimetrazine Dose Escalation</title>
          <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Intranasal cocaine (10, 20, 40 and 80 mg) was administered acutely after at least seven days of maintenance on each condition.&#xD;
Intransasal placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo were determined during maintenance on placebo and phendimetrazine.</description>
        </group>
      </group_list>
      <period_list>
        <period>
          <title>Overall Study</title>
          <milestone_list>
            <milestone>
              <title>STARTED</title>
              <participants_list>
                <participants group_id="P1" count="11"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>0 mg Cocaine With 0 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="11"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>10 mg Cocaine With 0 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="11"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>20 mg Cocaine With 0 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>40 mg Cocaine With 0 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>80 mg Cocaine With 0 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>0 mg Cocaine With 70 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>10 mg Cocaine With 70 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>20 mg Cocaine With 70 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>40 mg Cocaine With 70 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>80 mg Cocaine With 70 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>0 mg Cocaine With 140 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>10 mg Cocaine with140 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>20 mg Cocaine with140 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>40 mg Cocaine with140 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>80 mg Cocaine with140 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>0 mg Cocaine With 210 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>10 mg Cocaine with210 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>20 mg Cocaine with210 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>40 mg Cocaine with210 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>80 mg Cocaine with210 mg Phendimetrazine</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="10"/>
              </participants_list>
            </milestone>
            <milestone>
              <title>NOT COMPLETED</title>
              <participants_list>
                <participants group_id="P1" count="1"/>
              </participants_list>
            </milestone>
          </milestone_list>
          <drop_withdraw_reason_list>
            <drop_withdraw_reason>
              <title>Adverse Event</title>
              <participants_list>
                <participants group_id="P1" count="1"/>
              </participants_list>
            </drop_withdraw_reason>
          </drop_withdraw_reason_list>
        </period>
      </period_list>
    </participant_flow>

    <baseline>
      <population>These are data for completing subjects only. Eleven subjects were enrolled (i.e., signed consent), but only data from completing subjects were included here and in the outcomes listed throughout this report.</population>
      <group_list>
        <group group_id="B1">
          <title>Phendimetrazine Dose Escalation</title>
          <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
        </group>
      </group_list>
      <analyzed_list>
        <analyzed>
          <units>Participants</units>
          <scope>Overall</scope>
          <count_list>
            <count group_id="B1" value="10"/>
          </count_list>
        </analyzed>
      </analyzed_list>
      <measure_list>
        <measure>
          <title>Age</title>
          <units>years</units>
          <param>Mean</param>
          <dispersion>Standard Deviation</dispersion>
          <class_list>
            <class>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="43" spread="4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Sex: Female, Male</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>Female</title>
                  <measurement_list>
                    <measurement group_id="B1" value="1"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Male</title>
                  <measurement_list>
                    <measurement group_id="B1" value="9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Ethnicity (NIH/OMB)</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>Hispanic or Latino</title>
                  <measurement_list>
                    <measurement group_id="B1" value="1"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Not Hispanic or Latino</title>
                  <measurement_list>
                    <measurement group_id="B1" value="9"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Unknown or Not Reported</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Race (NIH/OMB)</title>
          <units>Participants</units>
          <param>Count of Participants</param>
          <class_list>
            <class>
              <category_list>
                <category>
                  <title>American Indian or Alaska Native</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Asian</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Native Hawaiian or Other Pacific Islander</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Black or African American</title>
                  <measurement_list>
                    <measurement group_id="B1" value="6"/>
                  </measurement_list>
                </category>
                <category>
                  <title>White</title>
                  <measurement_list>
                    <measurement group_id="B1" value="4"/>
                  </measurement_list>
                </category>
                <category>
                  <title>More than one race</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                  </measurement_list>
                </category>
                <category>
                  <title>Unknown or Not Reported</title>
                  <measurement_list>
                    <measurement group_id="B1" value="0"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
        <measure>
          <title>Region of Enrollment</title>
          <units>participants</units>
          <param>Number</param>
          <class_list>
            <class>
              <title>United States</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="B1" value="10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </measure_list>
    </baseline>

    <outcome_list>
      <outcome>
        <type>Primary</type>
        <title>Peak Systolic Pressure</title>
        <description>Systolic blood pressure was measured with an automated monitor. Higher values represent greater systolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Systolic Pressure</title>
          <description>Systolic blood pressure was measured with an automated monitor. Higher values represent greater systolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
          <units>mm Hg</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="115.4" spread="2.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="121.3" spread="3.51"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="123.4" spread="4.06"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="122.1" spread="2.86"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="135.4" spread="3.89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="120.0" spread="7.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="119.7" spread="3.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="119.9" spread="3.8"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="125.4" spread="6.05"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="130.3" spread="2.9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="117.9" spread="4.78"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="121.7" spread="4.73"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="122.1" spread="4.4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="121.5" spread="4.51"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="131.9" spread="3.6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="119.2" spread="3.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="119.7" spread="4.09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="119.8" spread="2.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="119.3" spread="2.72"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="130.9" spread="2.95"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Peak Diastolic Pressure</title>
        <description>Diastolic blood pressure was measured with an automated monitor. Higher values represent greater diastolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Diastolic Pressure</title>
          <description>Diastolic blood pressure was measured with an automated monitor. Higher values represent greater diastolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
          <units>mm Hg</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="75.6" spread="1.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="75.2" spread="1.63"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="78.4" spread="1.88"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="78" spread="1.38"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="80.8" spread="1.87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="77.2" spread="2.7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="76.7" spread="2.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="75.6" spread="2.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="75.6" spread="3.02"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="83.2" spread="2.69"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="74.3" spread="1.72"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="76" spread="1.84"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="78.1" spread="1.29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="77.7" spread="2.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="83.6" spread="1.26"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="76.6" spread="2.42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="77.9" spread="1.99"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="80.7" spread="2.34"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="78.6" spread="1.83"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="84.8" spread="2.37"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Peak Heart Rate</title>
        <description>Heart rate was measured with an automated monitor. Higher values represent greater heart rate. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Heart Rate</title>
          <description>Heart rate was measured with an automated monitor. Higher values represent greater heart rate. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
          <units>Beats per Minute</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="75" spread="3.72"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="72.7" spread="2.64"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="77.4" spread="4.19"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="79.2" spread="4.63"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="87.8" spread="5.6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="76.6" spread="2.57"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="75.3" spread="3.21"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="77" spread="3.06"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="81" spread="4.48"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="83.8" spread="3.92"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="82.1" spread="4.07"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="81.1" spread="3.87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="83.4" spread="4.81"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="83.5" spread="3.66"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="84.8" spread="4.03"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="84.9" spread="2.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="77.5" spread="2.2"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="85.3" spread="4.05"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="82.8" spread="3.08"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="88.9" spread="4.13"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Primary</type>
        <title>Peak Temperature</title>
        <description>Oral temperature was measured with an automated monitor. Higher values represent greater temperature. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Temperature</title>
          <description>Oral temperature was measured with an automated monitor. Higher values represent greater temperature. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.</description>
          <units>Degrees Fahrenheit</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.09" spread=".13"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.12" spread=".17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.24" spread=".12"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.21" spread=".15"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.04" spread=".29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.25" spread=".07"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.28" spread=".08"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.25" spread=".12"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.24" spread=".22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.32" spread=".17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.19" spread=".04"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.17" spread=".06"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.25" spread=".05"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.2" spread=".09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.3" spread=".04"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.41" spread=".07"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.17" spread=".06"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.18" spread=".08"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.24" spread=".07"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="98.38" spread=".1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Score on Sedative Subscale of the Adjective Rating Scale</title>
        <description>Subjects completed 16 items that loaded into the Sedative Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 &quot;sedative&quot; items was summed to yield the Sedative Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Score on Sedative Subscale of the Adjective Rating Scale</title>
          <description>Subjects completed 16 items that loaded into the Sedative Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 &quot;sedative&quot; items was summed to yield the Sedative Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.3" spread=".68"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.5" spread=".96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.5" spread=".99"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.4" spread=".82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.4" spread="1.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread=".59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.2" spread="1.03"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.5" spread="1.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.2" spread="2.27"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.2" spread="2.06"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.1" spread="1.22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.7" spread="1.56"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.1" spread="1.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.8" spread="1.52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.0" spread="2.19"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread=".57"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.6" spread=".9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.8" spread="1.4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.2" spread="1.68"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.7" spread="2.26"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Score on Stimulant Subscale of the Adjective Rating Scale</title>
        <description>Subjects completed 16 items that loaded into the Stimulant Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 &quot;stimulant&quot; items was summed to yield the Stimulant Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Score on Stimulant Subscale of the Adjective Rating Scale</title>
          <description>Subjects completed 16 items that loaded into the Stimulant Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 &quot;stimulant&quot; items was summed to yield the Stimulant Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.2" spread="1.05"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.5" spread="1.33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.3" spread="1.52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.6" spread="1.64"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.1" spread="1.47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.4" spread=".97"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.2" spread=".92"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.3" spread="1.17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.2" spread=".9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.3" spread="1.26"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.7" spread="1.10"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.3" spread=".91"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.8" spread="1.18"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.8" spread="1.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.1" spread="1.43"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.7" spread="1.08"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.2" spread="1.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.4" spread="1.38"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.3" spread="1.35"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9" spread="1.23"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Active, Alert, Energetic&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Active, Alert, Energetic&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Active, Alert, Energetic&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Active, Alert, Energetic&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.9" spread="1.91"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.9" spread="3.89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.8" spread="4.99"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14" spread="6.23"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6" spread="2.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9" spread="3.87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="13.4" spread="3.91"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="16" spread="4.17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4" spread="1.76"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.4" spread="4.7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14.8" spread="4.7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="18.9" spread="5.31"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread=".85"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.1" spread="3.71"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.1" spread="3.89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="17" spread="5.8"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Any Effect&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Any Effect&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Any Effect&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Any Effect&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread=".83"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.7" spread="1.57"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="13.2" spread="4.93"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="16.9" spread="4.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="26" spread="6.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".64"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.7" spread="2.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="13.5" spread="4.84"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="21.2" spread="6.9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="27.3" spread="7.81"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7" spread="1.99"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12.8" spread="3.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="19" spread="4.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="28.1" spread="4.86"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.6" spread="2.74"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.5" spread="3.37"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14.7" spread="4.33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="21.5" spread="4.25"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="35.1" spread="7.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Bad Effect&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Bad Effect&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Bad Effect&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Bad Effect&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.1" spread="1.3"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.9" spread="3.52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.6" spread="4.04"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.5" spread="4.74"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.3" spread=".87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2" spread="1.42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.6" spread="2.4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.9" spread="2.70"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.6" spread="3.73"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread="1.33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.7" spread="3.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.7" spread="2.63"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.4" spread="5.39"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.2" spread="7.77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.4" spread="1.52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.9" spread="2.17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.1" spread="4.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.2" spread="7.23"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Euphoric&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Euphoric&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Euphoric&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Euphoric&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread=".87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.1" spread="1.87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.2" spread=".81"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread="1.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.2" spread="1.52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.2" spread=".63"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2" spread="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".64"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2" spread="1.16"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.3" spread=".7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.3" spread=".7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".48"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".4" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".68"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.7" spread=".82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Good Effect&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Good Effect&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Good Effect&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Good Effect&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.2" spread=".73"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.1" spread="2.74"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12.4" spread="4.61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12.3" spread="5.27"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="19.8" spread="7.01"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.3" spread=".94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.1" spread="2.48"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.7" spread="3.77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="15.3" spread="5.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="21.3" spread="5.57"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.1" spread="1.13"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.1" spread="2.67"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.9" spread="3.9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="15.4" spread="5.39"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="27.8" spread="6.5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.2" spread="7.77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12" spread="4.51"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="16.7" spread="6.33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="17.1" spread="4.33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="27.2" spread="7.56"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;High&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;High&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;High&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;High&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.4" spread=".69"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6" spread="2.29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14.1" spread="4.9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.9" spread="4.81"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="23.4" spread="6.42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.1" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.6" spread="1.18"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.8" spread="4.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="13.3" spread="5.55"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="18.6" spread="6.52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.3" spread="2.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.1" spread="4.39"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="15.8" spread="5.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="24.2" spread="6.77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.3" spread="4.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="15.3" spread="6.35"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12.1" spread="3.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="22.6" spread="7.05"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Irregular/Racing Heartbeat&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Irregular/Racing Heartbeat&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Irregular/Racing Heartbeat&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Irregular/Racing Heartbeat&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".51"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.8" spread="1.19"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.8" spread="4.07"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.2" spread="5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14.6" spread="7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".4" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.6" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.9" spread="3.7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.4" spread="1.3"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6" spread="2.9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".55"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.6" spread="2.56"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.10" spread="2.15"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.2" spread="4.17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.3" spread="1.21"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4" spread="3.36"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.5" spread="3.48"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.8" spread="4.85"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Like Drug&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Like Drug&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Like Drug&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Like Drug&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.4" spread="2.01"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12.9" spread="4.58"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14" spread="5.82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="23.2" spread="8.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.1" spread="1.49"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.7" spread="3.52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="17.9" spread="5.13"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="25" spread="6.93"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.2" spread=".8"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.8" spread="3.16"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.9" spread="3.93"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="18" spread="6.01"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="26.2" spread="6.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.2" spread="1.44"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.5" spread="2.66"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="13.1" spread="4.72"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="25.5" spread="9.3"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="26.5" spread="8.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Nauseated/Queasy/Sick to Stomach&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Nauseated/Queasy/Sick to Stomach&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Nauseated/Queasy/Sick to Stomach&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Nauseated/Queasy/Sick to Stomach&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.4" spread=".69"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="1.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.1" spread="1.29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.8" spread="2.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14" spread="5.79"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".43"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.3" spread="2.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.3" spread="2.17"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.3" spread="4.22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.5" spread="5.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.1" spread="2.77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.9" spread="1.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.9" spread="3.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.7" spread="5.7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.2" spread="4.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.7" spread="1.25"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.8" spread="2.83"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.3" spread="2.54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.9" spread="1.89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Nervous/Anxious&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Nervous/Anxious&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Nervous/Anxious&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Nervous/Anxious&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.3" spread="1.12"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.7" spread="2.27"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.1" spread="2.61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.4" spread="6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".43"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2" spread="1.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.4" spread="2.50"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.7" spread="4.46"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.7" spread=".75"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.5" spread="1.24"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.7" spread="2.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.5" spread="4.22"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".55"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.7" spread="2.13"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.4" spread="2.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.1" spread="6.52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Willing to Pay For&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Willing to Pay For&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Willing to Pay For&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Willing to Pay For&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.4" spread="2.49"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.2" spread="3.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.2" spread="4.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="20.2" spread="7.01"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.1" spread=".72"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.4" spread=".86"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.4" spread="2.9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14.1" spread="4.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="19.3" spread="5.63"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.2" spread="2.15"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.9" spread="3.82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="18.3" spread="6.58"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="23" spread="5.77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.7" spread="1.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6" spread="2.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.9" spread="4.39"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12.3" spread="3.77"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="23.1" spread="9.27"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Performance Impaired&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Performance Impaired&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Performance Impaired&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Performance Impaired&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread=".98"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="1.24"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.4" spread="1.31"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".68"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.2" spread="1.12"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".55"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.9" spread="2.82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.5" spread="3.56"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.1" spread="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.7" spread="1.78"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".55"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".3" spread=".3"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.6" spread="5.07"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.4" spread="3.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.6" spread="5.24"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Performance Improved&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Performance Improved&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Performance Improved&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Performance Improved&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.4" spread=".72"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.4" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.6" spread="4.49"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread=".91"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.8" spread="3.31"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.4" spread="1.15"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.6" spread="2.84"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.1" spread="3.58"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread="1.29"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.6" spread="1.06"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.9" spread="2.9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.6" spread="1.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Restless&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Restless&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Restless&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Restless&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread="1.08"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="1.01"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.3" spread="1.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.1" spread=".64"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".54"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".68"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread=".9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.3" spread="1.67"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.1" spread="1.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4" spread="2.04"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.6" spread=".99"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.7" spread="2.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.0" spread="1.61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.6" spread="1.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.9" spread="5.38"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Rush&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Rush&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Rush&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Rush&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.4" spread="2.4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.9" spread="4.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.4" spread="5.93"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="17.4" spread="7.06"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.4" spread="1.5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8" spread="3.73"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.1" spread="4.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="20" spread="7.11"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".67"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.67" spread="2.12"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.2" spread="3.44"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="16.3" spread="5.95"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="21.8" spread="6.03"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.4" spread=".86"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.3" spread="2.49"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.3" spread="3.62"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="13.2" spread="4.55"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="16.9" spread="5.58"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Shaky/Jittery&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Shaky/Jittery&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Shaky/Jittery&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Shaky/Jittery&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.7" spread=".88"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread=".88"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.1" spread="3.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6" spread="3.78"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.9" spread="7.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".4" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".5"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="1.05"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.4" spread="1.61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.5" spread="3.39"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.4" spread=".79"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".9" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.8" spread="1.7"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.9" spread="2.3"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12.8" spread="5.33"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".3" spread=".3"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".55"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread="1.04"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6.6" spread="2.92"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9" spread="5.58"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Sluggish/Fatigued/Lazy&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Sluggish/Fatigued/Lazy&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Sluggish/Fatigued/Lazy&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Sluggish/Fatigued/Lazy&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.7" spread=".9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread="1.09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.09" spread="1"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="1.81"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.5" spread="5.85"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".43"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.0" spread="1.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.3" spread="2.47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.3" spread="3.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="6" spread="3.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.8" spread="2.27"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.6" spread="2.47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.3" spread="2.94"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.9" spread="5.49"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7" spread="5.82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.5" spread="2.67"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.8" spread="2.64"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.2" spread="2.63"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.8" spread="7.16"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Stimulated&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Stimulated&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Stimulated&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Stimulated&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.8" spread=".8"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2" spread=".93"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.6" spread="2.9"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.1" spread="2.56"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.8" spread="4.92"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".8" spread=".53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.7" spread="1.55"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.9" spread="2.61"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.9" spread="4.42"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="12.4" spread="4.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.6" spread=".82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.9" spread="1.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.5" spread="3.59"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.6" spread="5.36"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="10.9" spread="5.12"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.2" spread="1.14"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.4" spread="1.56"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.8" spread="2.45"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.1" spread="3.52"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14.7" spread="6.91"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Willing to Take Again&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Willing to Take Again&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Willing to Take Again&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Willing to Take Again&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.1" spread=".66"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="9.8" spread="5.13"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="14.1" spread="5.44"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="16.5" spread="7.26"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="22.9" spread="8.82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.5" spread=".89"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.5" spread=".96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="13" spread="3.86"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="20.7" spread="5.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="26.7" spread="7.53"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".63"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8.8" spread="4.12"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.1" spread="4.8"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="19.4" spread="5.81"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="25.8" spread="5.2"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2" spread="1.32"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.2" spread="5.20"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="11.6" spread="4.69"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="17.9" spread="5.15"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="30" spread="8.78"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
      <outcome>
        <type>Secondary</type>
        <title>Peak Ratings of &quot;Talkative/Friendly&quot; on the Visual Analog Scale</title>
        <description>Subjects rated their feelings of &quot;Talkative/Friendly&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
        <time_frame>This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.</time_frame>
        <group_list>
          <group group_id="O1">
            <title>Phendimetrazine Dose Escalation</title>
            <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine.</description>
          </group>
        </group_list>
        <measure>
          <title>Peak Ratings of &quot;Talkative/Friendly&quot; on the Visual Analog Scale</title>
          <description>Subjects rated their feelings of &quot;Talkative/Friendly&quot; on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.</description>
          <units>units on a scale</units>
          <param>Mean</param>
          <dispersion>Standard Error</dispersion>
          <analyzed_list>
            <analyzed>
              <units>Participants</units>
              <scope>Measure</scope>
              <count_list>
                <count group_id="O1" value="10"/>
              </count_list>
            </analyzed>
          </analyzed_list>
          <class_list>
            <class>
              <title>0 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.7" spread="1.28"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.9" spread="2.96"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.5" spread="2.4"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 0 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="4.3" spread="2.82"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".6" spread=".6"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="2.7" spread="1.21"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="5.4" spread="2.63"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.3" spread="3.09"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 70 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="8" spread="3.87"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1" spread=".68"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.2" spread=".81"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread="1.04"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.2" spread="1.65"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 140 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="7.2" spread="2.74"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>0 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".7" spread=".47"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>10 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value=".5" spread=".34"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>20 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.9" spread=".92"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>40 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="1.7" spread="1.11"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
            <class>
              <title>80 mg Cocaine with 210 mg Phendimetrazine</title>
              <category_list>
                <category>
                  <measurement_list>
                    <measurement group_id="O1" value="3.4" spread="1.43"/>
                  </measurement_list>
                </category>
              </category_list>
            </class>
          </class_list>
        </measure>
      </outcome>
    </outcome_list>

    <reported_events>
      <group_list>
        <group group_id="E1">
          <title>Phendimetrazine Dose Escalation</title>
          <description>Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order.&#xD;
Intranasal cocaine (10, 20, 40 and 80 mg) was administered acutely after at least seven days of maintenance on each condition.&#xD;
Intransasal placebo cocaine was administered acutely after at least seven days of maintenance on each condition.&#xD;
Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine.&#xD;
Placebo: The pharmacodynamic effects of placebo were determined during maintenance on placebo and phendimetrazine.</description>
        </group>
      </group_list>
      <serious_events>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, serious adverse events</sub_title>
                <counts group_id="E1" subjects_affected="0" subjects_at_risk="11"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </serious_events>
      <other_events>
        <frequency_threshold>5</frequency_threshold>
        <default_assessment>Systematic Assessment</default_assessment>
        <category_list>
          <category>
            <title>Total</title>
            <event_list>
              <event>
                <sub_title>Total, other adverse events</sub_title>
                <counts group_id="E1" subjects_affected="1" subjects_at_risk="11"/>
              </event>
            </event_list>
          </category>
          <category>
            <title>Cardiac disorders</title>
            <event_list>
              <event>
                <sub_title>Persistent Tachycardia</sub_title>
                <description>One subject experienced persistent tachycardia after receiving 10 mg cocaine during placebo maintenance and was discharged from the protocol after the event resolved.</description>
                <counts group_id="E1" events="1" subjects_affected="1" subjects_at_risk="11"/>
              </event>
            </event_list>
          </category>
        </category_list>
      </other_events>
    </reported_events>

    <certain_agreements>
      <pi_employee>Principal Investigators are NOT employed by the organization sponsoring the study.</pi_employee>
      <restrictive_agreement>There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed. </restrictive_agreement>
    </certain_agreements>
    <point_of_contact>
      <name_or_title>William W. Stoops, Ph.D.</name_or_title>
      <organization>University of Kentucky</organization>
      <phone>859-257-5388</phone>
      <email>william.stoops@uky.edu</email>
    </point_of_contact>
  </clinical_results>
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT02233647
org study id: BED (IN) 29
nct id: NCT02233647
lead sponsor: 
collaborator: 
has dmc: No
This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a
      pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will
      be conducted in which the subjective and physiological effects of cocaine are evaluated
      during maintenance on placebo and phendimetrazine.
allocation: Non-Randomized
intervention model: Crossover Assignment
primary purpose: Basic Science
masking: Triple (Participant, Care Provider, Outcomes Assessor)
measure: Peak Systolic Pressure
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Systolic blood pressure was measured with an automated monitor. Higher values represent greater systolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.
measure: Peak Diastolic Pressure
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Diastolic blood pressure was measured with an automated monitor. Higher values represent greater diastolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.
measure: Peak Heart Rate
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Heart rate was measured with an automated monitor. Higher values represent greater heart rate. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.
measure: Peak Temperature
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Oral temperature was measured with an automated monitor. Higher values represent greater temperature. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions.
measure: Peak Score on Sedative Subscale of the Adjective Rating Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects completed 16 items that loaded into the Sedative Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 "sedative" items was summed to yield the Sedative Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Score on Stimulant Subscale of the Adjective Rating Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects completed 16 items that loaded into the Stimulant Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 "stimulant" items was summed to yield the Stimulant Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Active, Alert, Energetic" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Active, Alert, Energetic" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Any Effect" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Any Effect" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Bad Effect" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Bad Effect" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Euphoric" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Euphoric" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Good Effect" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Good Effect" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "High" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "High" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Irregular/Racing Heartbeat" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Irregular/Racing Heartbeat" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Like Drug" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Like Drug" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Nauseated/Queasy/Sick to Stomach" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Nauseated/Queasy/Sick to Stomach" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Nervous/Anxious" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Nervous/Anxious" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Willing to Pay For" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Willing to Pay For" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Performance Impaired" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Performance Impaired" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Performance Improved" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Performance Improved" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Restless" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Restless" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Rush" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Rush" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Shaky/Jittery" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Shaky/Jittery" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Sluggish/Fatigued/Lazy" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Sluggish/Fatigued/Lazy" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Stimulated" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Stimulated" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Willing to Take Again" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Willing to Take Again" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
measure: Peak Ratings of "Talkative/Friendly" on the Visual Analog Scale
time frame: This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions.
description: Subjects rated their feelings of "Talkative/Friendly" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions.
arm group label: Placebo
arm group type: Placebo Comparator
description: Subjects will be maintained on oral placebo. Cocaine will be administered acutely during placebo maintenance. Placebo will be administered acutely during placebo maintenance.
arm group label: Phendimetrazine Dose 1
arm group type: Experimental
description: Subjects will be maintained on the low phendimetrazine dose. Cocaine will be administered acutely during low dose phendimetrazine maintenance.
Placebo will be administered acutely during low dose phendimetrazine maintenance.
arm group label: Phendimetrazine Dose 2
arm group type: Experimental
description: Subjects will be maintained on the intermediate phendimetrazine dose. Cocaine will be administered acutely during intermediate dose phendimetrazine maintenance.
Placebo will be administered acutely during intermediate dose phendimetrazine maintenance.
arm group label: Phendimetrazine Dose 3
arm group type: Experimental
description: Subjects will be maintained on the high phendimetrazine dose. Cocaine will be administered acutely during high dose phendimetrazine maintenance.
Placebo will be administered acutely during high dose phendimetrazine maintenance.
intervention type: Drug
intervention name: Cocaine
description: The pharmacodynamic effects of cocaine will be determined during maintenance on placebo and phendimetrazine.
arm group label: Phendimetrazine Dose 1
arm group label: Phendimetrazine Dose 2
arm group label: Phendimetrazine Dose 3
arm group label: Placebo
intervention type: Drug
intervention name: Placebo
description: The pharmacodynamic effects of placebo will be determined during maintenance on placebo and phendimetrazine.
arm group label: Phendimetrazine Dose 1
arm group label: Phendimetrazine Dose 2
arm group label: Phendimetrazine Dose 3
arm group label: Placebo
criteria: 
gender: All
minimum age: 18 Years
maximum age: 55 Years
healthy volunteers: Accepts Healthy Volunteers
last name: William W Stoops, Ph.D.
role: Principal Investigator
affiliation: University of Kentucky
facility: 
country: United States
responsible party type: Sponsor-Investigator
investigator affiliation: University of Kentucky
investigator full name: William Stoops
investigator title: Associate Professor
mesh term: Cocaine
participant flow: 
baseline: 
outcome list: 
reported events: 
certain agreements: 
point of contact: 