<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT01679093</url>
  </required_header>
  <id_info>
    <org_study_id>2008-002701-40</org_study_id>
    <nct_id>NCT01679093</nct_id>
  </id_info>
  <brief_title>Antagonism Research Between Antiemetics Agents and Acetaminophen in Thyroidectomy's Post-operative Analgesia.</brief_title>
  <acronym>ANPATHY</acronym>
  <official_title>Antagonism Research Between Antiemetics Agents (Droperidol, Dexametasone, Ondansetron) and Acetaminophen in Thyroidectomy's Post-operative Analgesia.</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University Hospital, Lille</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>University Hospital, Lille</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The purpose of our study is to determine if there is an antagonism between drugs used in the&#xD;
      prevention of postoperative nausea and vomiting (PONV) on the analgesia led by acetaminophen&#xD;
      after thyroidectomy.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      It was shown that there was an antagonism of the ondansetron on the analgesia led by&#xD;
      acetaminophen in a model of nociception by electrical stimulation using the PainMatcher in&#xD;
      healthy volunteers. Our study try to determinate if a such antagonism exist in clinical&#xD;
      conditions : 66 patients with an Apfel-score II undergoing thyroidectomy were randomized in 3&#xD;
      equal groups. Each group received an antiemetic (ondansetron, droperidol or dexamethasone) at&#xD;
      the begining of the intervention and paracetamol at the end of the intervention for the&#xD;
      postoperative analgesia. During 2 hours in the postoperative unit, we raised : the electrical&#xD;
      pain's threshold with the PainMatcher, the numeric pain intensity scale and the presence of&#xD;
      nausea or vomiting. For each patients we determined the cytochrome P450 2D6 activity that&#xD;
      should have been able to explain a diminution of ondansetron's efficiency. Paracetamol blood&#xD;
      levels were also raised in the postoperative unit.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date>June 2009</start_date>
  <completion_date type="Actual">June 2011</completion_date>
  <primary_completion_date type="Actual">January 2011</primary_completion_date>
  <phase>Phase 3</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>&quot;electric nociception threshold&quot; measured by PainMatcher</measure>
    <time_frame>during 2 hours after thyroidectomy in the postoperative care unit</time_frame>
    <description>The PainMatcher is a pain self-assessment device using the electric stimulation of the median nerve. The patient maintains a pressure on an electrode box between the thumb and the index finger, creating a current of increasing intensity. The threshold of pain sensation is obtained when the patient releases his fingers from the electrode box. So whe raise the electric nociceptive threshold showned by the PainMatcher. We realize two measures and consider the second one.&#xD;
objective measure.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>numeric rating scale score</measure>
    <time_frame>during 2 hours after thyroidectomy in the postoperative care unit</time_frame>
    <description>to evaluate the sensation of pain with a 11 levels going from 0 ( no pain) to 10 ( worst pain imaginable).&#xD;
subjective measure.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>need in rescue analgesia with nefopam in case of numeric rating scale score &gt; 4</measure>
    <time_frame>during 2 hours after thyroidectomy in the postoperative care unit</time_frame>
  </secondary_outcome>
  <secondary_outcome>
    <measure>presence of postoperative nausea and vomiting</measure>
    <time_frame>during the 2 hours after thyroidectomy in the postoperative care unit</time_frame>
  </secondary_outcome>
  <number_of_arms>3</number_of_arms>
  <enrollment type="Actual">66</enrollment>
  <condition>Interaction Between Antiemetic Drugs and Paracetamol</condition>
  <arm_group>
    <arm_group_label>ONDANSETRON (OS)</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>patients receiving ondansetron at the beginning of the surgery to prevent postoperative nausea and vomiting (PONV); and paracetamol at the end of the surgery for postoperative analgesia.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>DROPERIDOL (DRO)</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>patients receiving droperidol at the beginning of the surgery to prevent PONV; and paracetamol at the end of the surgey for postoperative analgesia.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>DEXAMETHASONE (DEXA)</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>patients receiving dexamethasone at the beginning of the surgery to prevent PONV; and paracetamol at the end of the surgey for postoperative analgesia.</description>
  </arm_group>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>ondansetron</intervention_name>
    <description>ondansetron: 4 mg intravenous administration afer the induction of anesthesia.</description>
    <arm_group_label>ONDANSETRON (OS)</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Droperidol</intervention_name>
    <description>droperidol: 1.25 mg intravenous administration after the induction of anesthesia.</description>
    <arm_group_label>DROPERIDOL (DRO)</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Drug</intervention_type>
    <intervention_name>Dexamethasone</intervention_name>
    <description>dexametasone: 4 mg intravenous administration after the induction of anesthesia.</description>
    <arm_group_label>DEXAMETHASONE (DEXA)</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  patients undergoing thyroidectomy without lymph node dissection&#xD;
&#xD;
          -  American Society of Anesthesiologists physical status from I to III&#xD;
&#xD;
          -  Apfel-score equal to 2&#xD;
&#xD;
          -  informed consent signed&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  pregnant and breast-feeding women&#xD;
&#xD;
          -  addictive disorders&#xD;
&#xD;
          -  psychic diseases&#xD;
&#xD;
          -  allergy or contra-indication to a drug used in the study&#xD;
&#xD;
          -  presence of postoperative nausea or vomiting&#xD;
&#xD;
          -  administration of glucocorticoid for protecting recurrent laryngeal nerve.&#xD;
&#xD;
          -  protocol not respected&#xD;
&#xD;
          -  protocol refused by the patient&#xD;
&#xD;
          -  intellectual handicap&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>70 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Gilles Lebuffe, MD,PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>University hospital of Lille</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Hôpital Claude Huriez, CHRU</name>
      <address>
        <city>Lille</city>
        <zip>59000</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>France</country>
  </location_countries>
  <reference>
    <citation>Pickering G, Loriot MA, Libert F, Eschalier A, Beaune P, Dubray C. Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clin Pharmacol Ther. 2006 Apr;79(4):371-8. doi: 10.1016/j.clpt.2005.12.307.</citation>
    <PMID>16580905</PMID>
  </reference>
  <reference>
    <citation>Girard P, Pansart Y, Coppe MC, Niedergang B, Gillardin JM. Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice. Pharmacology. 2009;83(4):243-6. doi: 10.1159/000207448. Epub 2009 Mar 9.</citation>
    <PMID>19270466</PMID>
  </reference>
  <reference>
    <citation>Courade JP, Chassaing C, Bardin L, Alloui A, Eschalier A. 5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats. Eur J Pharmacol. 2001 Nov 30;432(1):1-7. doi: 10.1016/s0014-2999(01)01464-9.</citation>
    <PMID>11734181</PMID>
  </reference>
  <reference>
    <citation>Pickering G, Esteve V, Loriot MA, Eschalier A, Dubray C. Acetaminophen reinforces descending inhibitory pain pathways. Clin Pharmacol Ther. 2008 Jul;84(1):47-51. doi: 10.1038/sj.clpt.6100403. Epub 2007 Oct 24.</citation>
    <PMID>17957182</PMID>
  </reference>
  <reference>
    <citation>Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I, Zernak C, Danner K, Jokela R, Pocock SJ, Trenkler S, Kredel M, Biedler A, Sessler DI, Roewer N; IMPACT Investigators. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med. 2004 Jun 10;350(24):2441-51. doi: 10.1056/NEJMoa032196.</citation>
    <PMID>15190136</PMID>
  </reference>
  <reference>
    <citation>Apfel CC, Bacher A, Biedler A, Danner K, Danzeisen O, Eberhart LH, Forst H, Fritz G, Hergert M, Frings G, Goebel A, Hopf HB, Kerger H, Kranke P, Lange M, Mertzlufft F, Motsch J, Paura A, Roewer N, Schneider E, Stoecklein K, Wermelt J, Zernak C. [A factorial trial of six interventions for the prevention of postoperative nausea and vomiting]. Anaesthesist. 2005 Mar;54(3):201-9. doi: 10.1007/s00101-005-0803-8. German.</citation>
    <PMID>15731931</PMID>
  </reference>
  <reference>
    <citation>Kaiser R, Sezer O, Papies A, Bauer S, Schelenz C, Tremblay PB, Possinger K, Roots I, Brockmoller J. Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes. J Clin Oncol. 2002 Jun 15;20(12):2805-11. doi: 10.1200/JCO.2002.09.064.</citation>
    <PMID>12065557</PMID>
  </reference>
  <reference>
    <citation>Nielsen M, Olsen NV. Genetic polymorphisms in the cytochrome P450 system and efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Br J Anaesth. 2008 Oct;101(4):441-5. doi: 10.1093/bja/aen246. No abstract available.</citation>
    <PMID>18782884</PMID>
  </reference>
  <reference>
    <citation>Candiotti KA, Birnbach DJ, Lubarsky DA, Nhuch F, Kamat A, Koch WH, Nikoloff M, Wu L, Andrews D. The impact of pharmacogenomics on postoperative nausea and vomiting: do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis? Anesthesiology. 2005 Mar;102(3):543-9. doi: 10.1097/00000542-200503000-00011.</citation>
    <PMID>15731591</PMID>
  </reference>
  <reference>
    <citation>Pelissier T, Alloui A, Paeile C, Eschalier A. Evidence of a central antinociceptive effect of paracetamol involving spinal 5HT3 receptors. Neuroreport. 1995 Jul 31;6(11):1546-8. doi: 10.1097/00001756-199507310-00020.</citation>
    <PMID>7579145</PMID>
  </reference>
  <reference>
    <citation>Pelissier T, Alloui A, Caussade F, Dubray C, Cloarec A, Lavarenne J, Eschalier A. Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence. J Pharmacol Exp Ther. 1996 Jul;278(1):8-14.</citation>
    <PMID>8764329</PMID>
  </reference>
  <reference>
    <citation>Alloui A, Chassaing C, Schmidt J, Ardid D, Dubray C, Cloarec A, Eschalier A. Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats. Eur J Pharmacol. 2002 May 17;443(1-3):71-7. doi: 10.1016/s0014-2999(02)01578-9.</citation>
    <PMID>12044794</PMID>
  </reference>
  <reference>
    <citation>Lund I, Lundeberg T, Kowalski J, Sandberg L, Budh CN, Svensson E. Evaluation of variations in sensory and pain threshold assessments by electrocutaneous stimulation. Physiother Theory Pract. 2005 Apr-Jun;21(2):81-92. doi: 10.1080/09593980590922307.</citation>
    <PMID>16392461</PMID>
  </reference>
  <reference>
    <citation>Nielsen PR, Norgaard L, Rasmussen LS, Kehlet H. Prediction of post-operative pain by an electrical pain stimulus. Acta Anaesthesiol Scand. 2007 May;51(5):582-6. doi: 10.1111/j.1399-6576.2007.01271.x.</citation>
    <PMID>17430320</PMID>
  </reference>
  <reference>
    <citation>Fujii Y, Nakayama M. Efficacy of dexamethasone for reducing postoperative nausea and vomiting and analgesic requirements after thyroidectomy. Otolaryngol Head Neck Surg. 2007 Feb;136(2):274-7. doi: 10.1016/j.otohns.2006.09.013.</citation>
    <PMID>17275553</PMID>
  </reference>
  <reference>
    <citation>Samer CF, Piguet V, Dayer P, Desmeules JA. [Genetic polymorphism and drug interactions: their importance in the treatment of pain]. Can J Anaesth. 2005 Oct;52(8):806-21. doi: 10.1007/BF03021775. French.</citation>
    <PMID>16189332</PMID>
  </reference>
  <reference>
    <citation>Lo Y, Chia YY, Liu K, Ko NH. Morphine sparing with droperidol in patient-controlled analgesia. J Clin Anesth. 2005 Jun;17(4):271-5. doi: 10.1016/j.jclinane.2004.08.010.</citation>
    <PMID>15950851</PMID>
  </reference>
  <reference>
    <citation>McCleane GJ, Suzuki R, Dickenson AH. Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study. Anesth Analg. 2003 Nov;97(5):1474-1478. doi: 10.1213/01.ANE.0000085640.69855.51.</citation>
    <PMID>14570668</PMID>
  </reference>
  <reference>
    <citation>Andrieu G, Amrouni H, Robin E, Carnaille B, Wattier JM, Pattou F, Vallet B, Lebuffe G. Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia. Br J Anaesth. 2007 Oct;99(4):561-6. doi: 10.1093/bja/aem230. Epub 2007 Aug 6.</citation>
    <PMID>17681971</PMID>
  </reference>
  <verification_date>October 2016</verification_date>
  <study_first_submitted>August 31, 2012</study_first_submitted>
  <study_first_submitted_qc>August 31, 2012</study_first_submitted_qc>
  <study_first_posted type="Estimate">September 5, 2012</study_first_posted>
  <last_update_submitted>October 26, 2016</last_update_submitted>
  <last_update_submitted_qc>October 26, 2016</last_update_submitted_qc>
  <last_update_posted type="Estimate">October 27, 2016</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>postoperative analgesia</keyword>
  <keyword>paracetamol</keyword>
  <keyword>5-HT3 antagonist</keyword>
  <keyword>ondansetron</keyword>
  <keyword>PainMatcher</keyword>
  <intervention_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Dexamethasone</mesh_term>
    <mesh_term>Droperidol</mesh_term>
    <mesh_term>Ondansetron</mesh_term>
  </intervention_browse>
  <patient_data>
    <sharing_ipd>No</sharing_ipd>
  </patient_data>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT01679093
org study id: 2008-002701-40
nct id: NCT01679093
lead sponsor: 
has dmc: Yes
The purpose of our study is to determine if there is an antagonism between drugs used in the
      prevention of postoperative nausea and vomiting (PONV) on the analgesia led by acetaminophen
      after thyroidectomy.
It was shown that there was an antagonism of the ondansetron on the analgesia led by
      acetaminophen in a model of nociception by electrical stimulation using the PainMatcher in
      healthy volunteers. Our study try to determinate if a such antagonism exist in clinical
      conditions : 66 patients with an Apfel-score II undergoing thyroidectomy were randomized in 3
      equal groups. Each group received an antiemetic (ondansetron, droperidol or dexamethasone) at
      the begining of the intervention and paracetamol at the end of the intervention for the
      postoperative analgesia. During 2 hours in the postoperative unit, we raised : the electrical
      pain's threshold with the PainMatcher, the numeric pain intensity scale and the presence of
      nausea or vomiting. For each patients we determined the cytochrome P450 2D6 activity that
      should have been able to explain a diminution of ondansetron's efficiency. Paracetamol blood
      levels were also raised in the postoperative unit.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
measure: "electric nociception threshold" measured by PainMatcher
time frame: during 2 hours after thyroidectomy in the postoperative care unit
description: The PainMatcher is a pain self-assessment device using the electric stimulation of the median nerve. The patient maintains a pressure on an electrode box between the thumb and the index finger, creating a current of increasing intensity. The threshold of pain sensation is obtained when the patient releases his fingers from the electrode box. So whe raise the electric nociceptive threshold showned by the PainMatcher. We realize two measures and consider the second one.
objective measure.
measure: numeric rating scale score
time frame: during 2 hours after thyroidectomy in the postoperative care unit
description: to evaluate the sensation of pain with a 11 levels going from 0 ( no pain) to 10 ( worst pain imaginable).
subjective measure.
measure: need in rescue analgesia with nefopam in case of numeric rating scale score > 4
time frame: during 2 hours after thyroidectomy in the postoperative care unit
measure: presence of postoperative nausea and vomiting
time frame: during the 2 hours after thyroidectomy in the postoperative care unit
arm group label: ONDANSETRON (OS)
arm group type: Active Comparator
description: patients receiving ondansetron at the beginning of the surgery to prevent postoperative nausea and vomiting (PONV); and paracetamol at the end of the surgery for postoperative analgesia.
arm group label: DROPERIDOL (DRO)
arm group type: Active Comparator
description: patients receiving droperidol at the beginning of the surgery to prevent PONV; and paracetamol at the end of the surgey for postoperative analgesia.
arm group label: DEXAMETHASONE (DEXA)
arm group type: Active Comparator
description: patients receiving dexamethasone at the beginning of the surgery to prevent PONV; and paracetamol at the end of the surgey for postoperative analgesia.
intervention type: Drug
intervention name: ondansetron
description: ondansetron: 4 mg intravenous administration afer the induction of anesthesia.
arm group label: ONDANSETRON (OS)
intervention type: Drug
intervention name: Droperidol
description: droperidol: 1.25 mg intravenous administration after the induction of anesthesia.
arm group label: DROPERIDOL (DRO)
intervention type: Drug
intervention name: Dexamethasone
description: dexametasone: 4 mg intravenous administration after the induction of anesthesia.
arm group label: DEXAMETHASONE (DEXA)
criteria: 
gender: All
minimum age: 18 Years
maximum age: 70 Years
healthy volunteers: No
last name: Gilles Lebuffe, MD,PhD
role: Principal Investigator
affiliation: University hospital of Lille
facility: 
country: France
citation: Pickering G, Loriot MA, Libert F, Eschalier A, Beaune P, Dubray C. Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clin Pharmacol Ther. 2006 Apr;79(4):371-8. doi: 10.1016/j.clpt.2005.12.307.
PMID: 16580905
citation: Girard P, Pansart Y, Coppe MC, Niedergang B, Gillardin JM. Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice. Pharmacology. 2009;83(4):243-6. doi: 10.1159/000207448. Epub 2009 Mar 9.
PMID: 19270466
citation: Courade JP, Chassaing C, Bardin L, Alloui A, Eschalier A. 5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats. Eur J Pharmacol. 2001 Nov 30;432(1):1-7. doi: 10.1016/s0014-2999(01)01464-9.
PMID: 11734181
citation: Pickering G, Esteve V, Loriot MA, Eschalier A, Dubray C. Acetaminophen reinforces descending inhibitory pain pathways. Clin Pharmacol Ther. 2008 Jul;84(1):47-51. doi: 10.1038/sj.clpt.6100403. Epub 2007 Oct 24.
PMID: 17957182
citation: Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I, Zernak C, Danner K, Jokela R, Pocock SJ, Trenkler S, Kredel M, Biedler A, Sessler DI, Roewer N; IMPACT Investigators. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med. 2004 Jun 10;350(24):2441-51. doi: 10.1056/NEJMoa032196.
PMID: 15190136
citation: Apfel CC, Bacher A, Biedler A, Danner K, Danzeisen O, Eberhart LH, Forst H, Fritz G, Hergert M, Frings G, Goebel A, Hopf HB, Kerger H, Kranke P, Lange M, Mertzlufft F, Motsch J, Paura A, Roewer N, Schneider E, Stoecklein K, Wermelt J, Zernak C. [A factorial trial of six interventions for the prevention of postoperative nausea and vomiting]. Anaesthesist. 2005 Mar;54(3):201-9. doi: 10.1007/s00101-005-0803-8. German.
PMID: 15731931
citation: Kaiser R, Sezer O, Papies A, Bauer S, Schelenz C, Tremblay PB, Possinger K, Roots I, Brockmoller J. Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes. J Clin Oncol. 2002 Jun 15;20(12):2805-11. doi: 10.1200/JCO.2002.09.064.
PMID: 12065557
citation: Nielsen M, Olsen NV. Genetic polymorphisms in the cytochrome P450 system and efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Br J Anaesth. 2008 Oct;101(4):441-5. doi: 10.1093/bja/aen246. No abstract available.
PMID: 18782884
citation: Candiotti KA, Birnbach DJ, Lubarsky DA, Nhuch F, Kamat A, Koch WH, Nikoloff M, Wu L, Andrews D. The impact of pharmacogenomics on postoperative nausea and vomiting: do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis? Anesthesiology. 2005 Mar;102(3):543-9. doi: 10.1097/00000542-200503000-00011.
PMID: 15731591
citation: Pelissier T, Alloui A, Paeile C, Eschalier A. Evidence of a central antinociceptive effect of paracetamol involving spinal 5HT3 receptors. Neuroreport. 1995 Jul 31;6(11):1546-8. doi: 10.1097/00001756-199507310-00020.
PMID: 7579145
citation: Pelissier T, Alloui A, Caussade F, Dubray C, Cloarec A, Lavarenne J, Eschalier A. Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence. J Pharmacol Exp Ther. 1996 Jul;278(1):8-14.
PMID: 8764329
citation: Alloui A, Chassaing C, Schmidt J, Ardid D, Dubray C, Cloarec A, Eschalier A. Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats. Eur J Pharmacol. 2002 May 17;443(1-3):71-7. doi: 10.1016/s0014-2999(02)01578-9.
PMID: 12044794
citation: Lund I, Lundeberg T, Kowalski J, Sandberg L, Budh CN, Svensson E. Evaluation of variations in sensory and pain threshold assessments by electrocutaneous stimulation. Physiother Theory Pract. 2005 Apr-Jun;21(2):81-92. doi: 10.1080/09593980590922307.
PMID: 16392461
citation: Nielsen PR, Norgaard L, Rasmussen LS, Kehlet H. Prediction of post-operative pain by an electrical pain stimulus. Acta Anaesthesiol Scand. 2007 May;51(5):582-6. doi: 10.1111/j.1399-6576.2007.01271.x.
PMID: 17430320
citation: Fujii Y, Nakayama M. Efficacy of dexamethasone for reducing postoperative nausea and vomiting and analgesic requirements after thyroidectomy. Otolaryngol Head Neck Surg. 2007 Feb;136(2):274-7. doi: 10.1016/j.otohns.2006.09.013.
PMID: 17275553
citation: Samer CF, Piguet V, Dayer P, Desmeules JA. [Genetic polymorphism and drug interactions: their importance in the treatment of pain]. Can J Anaesth. 2005 Oct;52(8):806-21. doi: 10.1007/BF03021775. French.
PMID: 16189332
citation: Lo Y, Chia YY, Liu K, Ko NH. Morphine sparing with droperidol in patient-controlled analgesia. J Clin Anesth. 2005 Jun;17(4):271-5. doi: 10.1016/j.jclinane.2004.08.010.
PMID: 15950851
citation: McCleane GJ, Suzuki R, Dickenson AH. Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study. Anesth Analg. 2003 Nov;97(5):1474-1478. doi: 10.1213/01.ANE.0000085640.69855.51.
PMID: 14570668
citation: Andrieu G, Amrouni H, Robin E, Carnaille B, Wattier JM, Pattou F, Vallet B, Lebuffe G. Analgesic efficacy of bilateral superficial cervical plexus block administered before thyroid surgery under general anaesthesia. Br J Anaesth. 2007 Oct;99(4):561-6. doi: 10.1093/bja/aem230. Epub 2007 Aug 6.
PMID: 17681971
responsible party type: Sponsor
mesh term: Dexamethasone
mesh term: Droperidol
mesh term: Ondansetron
sharing ipd: No