<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT01733901</url>
  </required_header>
  <id_info>
    <org_study_id>21012-SR-132</org_study_id>
    <nct_id>NCT01733901</nct_id>
  </id_info>
  <brief_title>Renal Sympathetic Denervation as Secondary Prevention for Patients After Percutaneous Coronary Intervention.</brief_title>
  <acronym>RSD4CHD2PRE</acronym>
  <official_title>Safety and Effectiveness Study of Percutaneous Catheter-based Renal Sympathetic Denervation as a Method of Secondary Prevention for Patients After Percutaneous Coronary Intervention.</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>The First Affiliated Hospital with Nanjing Medical University</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>The First Affiliated Hospital with Nanjing Medical University</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      To study whether renal sympathetic denervation(RSD) will reduce the all-cause mortality and&#xD;
      the recurrence rate of a composite of cardiovascular event(including angina, myocardial&#xD;
      infarction, repeat percutaneous coronary intervention and coronary artery bypass grafting) in&#xD;
      patients after percutaneous coronary intervention(PCI). Besides whether RSD can reduce the&#xD;
      risk factors for coronary heart disease.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Coronary heart disease is the leading cause of death worldwide, contributing to over 7.2&#xD;
      million deaths annually. The main measures of secondary prevention of coronary heart disease&#xD;
      are optimizing drug therapy and changing lifestyle. optimizing drug therapy, including&#xD;
      aspirin, beta receptor blockers, lipid regulating drugs (mostly statins, a small part&#xD;
      fibrates) and vascular angiotensin-converting enzyme inhibitors. However, the situation for&#xD;
      secondary prevention of coronary heart disease is not satisfying. EuroASPIRE III survey found&#xD;
      that despite effective drug used in the primary or secondary prevention of coronary heart&#xD;
      disease, coronary heart disease risk factors, such as high blood glucose,hypertension, high&#xD;
      cholesterol and obesity, are still poorly controlled. At the same time sympathetic activation&#xD;
      plays an extremely important role in the development of coronary heart disease, and high&#xD;
      sympathetic activity after acute myocardial infarction is closely related to malignant&#xD;
      arrhythmia and heart failure. Recently, many clinical researches have verified that&#xD;
      catheter-based renal sympathetic denervation(RSD) can safely be used to substantially reduce&#xD;
      blood pressure, reduce left ventricular hypertrophy, improve glucose tolerance and sleep&#xD;
      apnea severity. Simultaneously, a marked reduction in muscle and whole-body sympathetic-nerve&#xD;
      activity(MSNA) is apparent, with a decrease in renal and whole-body norepinephrine spillover.&#xD;
      Hypertension, diabetes, high norepinephrine level and obstructive sleep apnea are all&#xD;
      recognized as risk factors for the development and recurrence of coronary heart disease. So,&#xD;
      we design this randomized parallel control clinical study to demonstrate whether RSD can&#xD;
      reduce the mortality and the recurrence rate of a composite of cardiovascular event in&#xD;
      patients after PCI, besides whether RSD can reduce the risk factors for coronary heart&#xD;
      disease.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date>November 2012</start_date>
  <completion_date type="Anticipated">July 2015</completion_date>
  <primary_completion_date type="Anticipated">November 2014</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>All-cause mortality</measure>
    <time_frame>24 months</time_frame>
    <description>To study the effect of renal sympathetic denervation(RSD) on all-cause mortality in patients after PCI</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Recurrent angina pectoris</measure>
    <time_frame>24 months</time_frame>
    <description>Previous symptoms of myocardial ischemia in patients relapsed or aggravated during follow-up, or ECG ST segment depressed compared with preoperative, or need to increase the dose of antianginal drug.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Myocardial infarction</measure>
    <time_frame>24 months</time_frame>
    <description>It can be diagnosed by symptoms, ECG and myocardial markers changes.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Vascular recanalization again</measure>
    <time_frame>24 months</time_frame>
    <description>Coronary angiography shows new stenosis during the follow-up and patients need PCI or coronary artery bypass grafting(CABG) again.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Chronic heart failure</measure>
    <time_frame>24 months</time_frame>
    <description>To study whether RSD can improve the patients' heart function. And it will be judged by the NYHA classification,BNP and echocardiography.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Arrhythmia</measure>
    <time_frame>24 months</time_frame>
    <description>If a new arrhythmia is discovered during the follow-up,it will be recorded. Patients may have symptoms of flustered, palpitations, dizziness, amaurosis, syncope and so on, which can be diagnosed by ECG and Holter.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Stroke</measure>
    <time_frame>24 months</time_frame>
    <description>During the follow-up if a new stroke occured,it will be recorded. And it can be diagnosed by symptoms, cranial CT or MRI.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Blood pressure</measure>
    <time_frame>24 months</time_frame>
    <description>To study the effect of renal sympathetic denervation on blood pressure in patients with hypertension,which can be measured by ambulatory blood pressure.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Blood sugar</measure>
    <time_frame>24 months</time_frame>
    <description>In order to study whether RSD can reduce the blood sugar level and insulin resistance of diabetic patients. It will be measured by fasting blood glucose, glycated hemoglobin and fasting insulin.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Renal function</measure>
    <time_frame>24 months</time_frame>
    <description>To study whether RSD can improve the patients' renal function, which will be measured by urine albumin, creatinine and urea nitrogen levels.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Pulse wave velocity</measure>
    <time_frame>24 months</time_frame>
    <description>So as to study whether RSD can improve the patients' blood vessel elasticity, a pulse wave velocity (PWV)will be carried on.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Life quality</measure>
    <time_frame>24 months</time_frame>
    <description>Life quality on 36-item short-form(SF-36)Health Survey Questionnaire will be carried out during the follow-up to study the patients' life quality.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Medication adherence</measure>
    <time_frame>24 months</time_frame>
    <description>To study the patients'Medication adherence,we will record the type ,the dose and use time of drugs patients used during the follow-up.</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Anticipated">600</enrollment>
  <condition>Coronary Heart Disease</condition>
  <arm_group>
    <arm_group_label>RSD+PCI+Medicine</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>We will recruit 300 randomised CHD patients who meet the inclusion criteria. First undergo percutaneous coronary intervention, and then perform the renal artery angiography procedure to confirm anatomy. If renal artery meet the inclusion criteria, give the renal sympathetic denervation. After renal sympathetic denervation traditional secondary prevention of coronary heart disease is recommend. Finally we will conduct a clinic follow-up every six month and a telephone follow-up every three month(Total 24 months).</description>
  </arm_group>
  <arm_group>
    <arm_group_label>PCI+Medicine</arm_group_label>
    <arm_group_type>Placebo Comparator</arm_group_type>
    <description>We aslo will recruit 300 randomised CHD patients who meet the inclusion criteria. There are no significant differences in age, gender, race, past medical history,personal history and so on between the two groups. In this group we will perform percutaneous coronary intervention firstly, then give traditional secondary prevention of coronary heart disease just like the RSD+PCI+Medicine group. Third we will conduct a clinic follow-up every six month and a telephone follow-up every three month(Total 24 months).</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>RSD</intervention_name>
    <description>Contrast renal angiography was performed to localize and assess the renal arteries for accessibility and appropriateness for RSD. Once the anatomy was deemed acceptable, the internally irrigated radiofrequency ablation catheter(Celcius Thermocool,Biosense Webster, Diamond Bar, California) was introduced into each renal artery. then was maneuvered within the renal artery to allow energy delivery in a circumferential, longitudinally staggered manner to minimize the chance of renal artery stenosis. About six to nine ablations at 10 W for 1 min each were performed in both renal arteries. During ablation, the catheter system monitored tip temperature and impedance, altering radiofrequency energy delivery in response to a predetermined algorithm.</description>
    <arm_group_label>RSD+PCI+Medicine</arm_group_label>
    <other_name>renal sympathetic denervation</other_name>
    <other_name>renal denervation</other_name>
    <other_name>renal ablation</other_name>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>PCI</intervention_name>
    <description>Percutaneous coronary intervention (PCI) is a non-surgical procedure used to treat the stenotic coronary arteries of the heart found in CHD. During PCI, a cardiologist feeds a deflated balloon or other device on a catheter from the inguinal femoral artery or radial artery up through blood vessels until they reach the site of blockage in the heart. X-ray imaging is used to guide the catheter threading. At the blockage, the balloon is inflated to open the artery, allowing blood to flow. A stent is often placed at the site of blockage to permanently open the artery.</description>
    <arm_group_label>PCI+Medicine</arm_group_label>
    <arm_group_label>RSD+PCI+Medicine</arm_group_label>
    <other_name>percutaneous coronary intervention</other_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. Individual is ≥ 18 and ≤75 years of age.&#xD;
&#xD;
          2. Individual has a clear history of coronary heart disease,and need underwent&#xD;
             percutaneous coronary intervention .&#xD;
&#xD;
          3. Blood pressure &gt;115/75mmHg.&#xD;
&#xD;
          4. Individual's cardiac function is between Ⅰ~Ⅲ level(NYHA)&#xD;
&#xD;
          5. Individual agrees to have all study procedures performed, and is competent and willing&#xD;
             to provide written, informed consent to participate in this clinical study&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Individual has hemodynamically significant valvular heart disease for which reduction&#xD;
             of blood pressure would be considered hazardous.&#xD;
&#xD;
          2. Individual has experienced renal artery stenosis,or A history of prior renal artery&#xD;
             intervention including balloon angioplasty or stenting. or ineligible conditions&#xD;
             through renal artery Computed Tomography Angiogram(CTA) inspection, such as double&#xD;
             renal artery on one side,renal artery length≤2cm, diameter≤4mm, and distortion at&#xD;
             incept sect.&#xD;
&#xD;
          3. Individual has an estimated glomerular filtration rate (eGFR) of &lt; 45mL/min/1.73m2,&#xD;
             using the MDRD calculation.&#xD;
&#xD;
          4. Individual has Acute heart failure.&#xD;
&#xD;
          5. Individual has experienced a cerebrovascular accident within 3 months of the screening&#xD;
             visit, or has widespread atherosclerosis, with documented intravascular thrombosis or&#xD;
             unstable plaques.&#xD;
&#xD;
          6. Individual has experienced sick sinus syndrome.&#xD;
&#xD;
          7. Individual has any serious medical condition, which in the opinion of the&#xD;
             investigator, may adversely affect the safety and/or effectiveness of the participant&#xD;
             or the study (i.e., patients with clinically significant peripheral vascular disease,&#xD;
             abdominal aortic aneurysm, bleeding disorders such as thrombocytopenia, hemophilia, or&#xD;
             significant anemia, or arrhythmias such as atrial fibrillation).&#xD;
&#xD;
          8. Individual is pregnant, nursing or planning to be pregnant. [Female participants of&#xD;
             childbearing potential must have a negative serum or urine human chorionic&#xD;
             gonadotropin (hCG) pregnancy test prior to treatment.]&#xD;
&#xD;
          9. Individual has a known, unresolved history of drug use or alcohol dependency, lacks&#xD;
             the ability to comprehend or follow instructions, or would be unlikely or unable to&#xD;
             comply with study follow-up requirements.&#xD;
&#xD;
         10. Individual is currently enrolled in another investigational drug or device trial.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>75 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Qijun Shan, professor</last_name>
    <role>Study Chair</role>
    <affiliation>The First Affiliated Hospital with Nanjing Medical University</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Qijun Shan, professor</last_name>
    <phone>0086 025 68136407</phone>
    <email>qjshan@njmu.edu.cn</email>
  </overall_contact>
  <location>
    <facility>
      <name>First Affiliated Hospital of Nanjing Medical University</name>
      <address>
        <city>Nanjing</city>
        <state>Jiangsu</state>
        <zip>210000</zip>
        <country>China</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <investigator>
      <last_name>Qijun Shan, Professor</last_name>
      <role>Principal Investigator</role>
    </investigator>
    <investigator>
      <last_name>Zhijian Yang, Professor</last_name>
      <role>Principal Investigator</role>
    </investigator>
    <investigator>
      <last_name>Chun Chen, Professor</last_name>
      <role>Principal Investigator</role>
    </investigator>
    <investigator>
      <last_name>Xiujuan Zhou, Professor</last_name>
      <role>Principal Investigator</role>
    </investigator>
    <investigator>
      <last_name>Weichong Qian, Professor</last_name>
      <role>Sub-Investigator</role>
    </investigator>
    <investigator>
      <last_name>Zhenhua Dai, Doctor</last_name>
      <role>Sub-Investigator</role>
    </investigator>
    <investigator>
      <last_name>Jie Gen, Master</last_name>
      <role>Sub-Investigator</role>
    </investigator>
    <investigator>
      <last_name>Zhongxia Zhou, Master</last_name>
      <role>Sub-Investigator</role>
    </investigator>
    <investigator>
      <last_name>Min Qiu, Doctor</last_name>
      <role>Sub-Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>China</country>
  </location_countries>
  <verification_date>November 2012</verification_date>
  <study_first_submitted>November 9, 2012</study_first_submitted>
  <study_first_submitted_qc>November 21, 2012</study_first_submitted_qc>
  <study_first_posted type="Estimate">November 27, 2012</study_first_posted>
  <last_update_submitted>November 21, 2012</last_update_submitted>
  <last_update_submitted_qc>November 21, 2012</last_update_submitted_qc>
  <last_update_posted type="Estimate">November 27, 2012</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>The First Affiliated Hospital with Nanjing Medical University</investigator_affiliation>
    <investigator_full_name>Qijun Shan</investigator_full_name>
    <investigator_title>Professor，Director, Cardiac Arrhythmia Group</investigator_title>
  </responsible_party>
  <keyword>Coronary heart disease</keyword>
  <keyword>PCI</keyword>
  <keyword>Renal sympathetic denervation</keyword>
  <keyword>Hypertension</keyword>
  <keyword>Diabetes</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Heart Diseases</mesh_term>
    <mesh_term>Coronary Disease</mesh_term>
    <mesh_term>Coronary Artery Disease</mesh_term>
    <mesh_term>Myocardial Ischemia</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT01733901
org study id: 21012-SR-132
nct id: NCT01733901
lead sponsor: 
has dmc: Yes
To study whether renal sympathetic denervation(RSD) will reduce the all-cause mortality and
      the recurrence rate of a composite of cardiovascular event(including angina, myocardial
      infarction, repeat percutaneous coronary intervention and coronary artery bypass grafting) in
      patients after percutaneous coronary intervention(PCI). Besides whether RSD can reduce the
      risk factors for coronary heart disease.
Coronary heart disease is the leading cause of death worldwide, contributing to over 7.2
      million deaths annually. The main measures of secondary prevention of coronary heart disease
      are optimizing drug therapy and changing lifestyle. optimizing drug therapy, including
      aspirin, beta receptor blockers, lipid regulating drugs (mostly statins, a small part
      fibrates) and vascular angiotensin-converting enzyme inhibitors. However, the situation for
      secondary prevention of coronary heart disease is not satisfying. EuroASPIRE III survey found
      that despite effective drug used in the primary or secondary prevention of coronary heart
      disease, coronary heart disease risk factors, such as high blood glucose,hypertension, high
      cholesterol and obesity, are still poorly controlled. At the same time sympathetic activation
      plays an extremely important role in the development of coronary heart disease, and high
      sympathetic activity after acute myocardial infarction is closely related to malignant
      arrhythmia and heart failure. Recently, many clinical researches have verified that
      catheter-based renal sympathetic denervation(RSD) can safely be used to substantially reduce
      blood pressure, reduce left ventricular hypertrophy, improve glucose tolerance and sleep
      apnea severity. Simultaneously, a marked reduction in muscle and whole-body sympathetic-nerve
      activity(MSNA) is apparent, with a decrease in renal and whole-body norepinephrine spillover.
      Hypertension, diabetes, high norepinephrine level and obstructive sleep apnea are all
      recognized as risk factors for the development and recurrence of coronary heart disease. So,
      we design this randomized parallel control clinical study to demonstrate whether RSD can
      reduce the mortality and the recurrence rate of a composite of cardiovascular event in
      patients after PCI, besides whether RSD can reduce the risk factors for coronary heart
      disease.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Single (Outcomes Assessor)
measure: All-cause mortality
time frame: 24 months
description: To study the effect of renal sympathetic denervation(RSD) on all-cause mortality in patients after PCI
measure: Recurrent angina pectoris
time frame: 24 months
description: Previous symptoms of myocardial ischemia in patients relapsed or aggravated during follow-up, or ECG ST segment depressed compared with preoperative, or need to increase the dose of antianginal drug.
measure: Myocardial infarction
time frame: 24 months
description: It can be diagnosed by symptoms, ECG and myocardial markers changes.
measure: Vascular recanalization again
time frame: 24 months
description: Coronary angiography shows new stenosis during the follow-up and patients need PCI or coronary artery bypass grafting(CABG) again.
measure: Chronic heart failure
time frame: 24 months
description: To study whether RSD can improve the patients' heart function. And it will be judged by the NYHA classification,BNP and echocardiography.
measure: Arrhythmia
time frame: 24 months
description: If a new arrhythmia is discovered during the follow-up,it will be recorded. Patients may have symptoms of flustered, palpitations, dizziness, amaurosis, syncope and so on, which can be diagnosed by ECG and Holter.
measure: Stroke
time frame: 24 months
description: During the follow-up if a new stroke occured,it will be recorded. And it can be diagnosed by symptoms, cranial CT or MRI.
measure: Blood pressure
time frame: 24 months
description: To study the effect of renal sympathetic denervation on blood pressure in patients with hypertension,which can be measured by ambulatory blood pressure.
measure: Blood sugar
time frame: 24 months
description: In order to study whether RSD can reduce the blood sugar level and insulin resistance of diabetic patients. It will be measured by fasting blood glucose, glycated hemoglobin and fasting insulin.
measure: Renal function
time frame: 24 months
description: To study whether RSD can improve the patients' renal function, which will be measured by urine albumin, creatinine and urea nitrogen levels.
measure: Pulse wave velocity
time frame: 24 months
description: So as to study whether RSD can improve the patients' blood vessel elasticity, a pulse wave velocity (PWV)will be carried on.
measure: Life quality
time frame: 24 months
description: Life quality on 36-item short-form(SF-36)Health Survey Questionnaire will be carried out during the follow-up to study the patients' life quality.
measure: Medication adherence
time frame: 24 months
description: To study the patients'Medication adherence,we will record the type ,the dose and use time of drugs patients used during the follow-up.
arm group label: RSD+PCI+Medicine
arm group type: Active Comparator
description: We will recruit 300 randomised CHD patients who meet the inclusion criteria. First undergo percutaneous coronary intervention, and then perform the renal artery angiography procedure to confirm anatomy. If renal artery meet the inclusion criteria, give the renal sympathetic denervation. After renal sympathetic denervation traditional secondary prevention of coronary heart disease is recommend. Finally we will conduct a clinic follow-up every six month and a telephone follow-up every three month(Total 24 months).
arm group label: PCI+Medicine
arm group type: Placebo Comparator
description: We aslo will recruit 300 randomised CHD patients who meet the inclusion criteria. There are no significant differences in age, gender, race, past medical history,personal history and so on between the two groups. In this group we will perform percutaneous coronary intervention firstly, then give traditional secondary prevention of coronary heart disease just like the RSD+PCI+Medicine group. Third we will conduct a clinic follow-up every six month and a telephone follow-up every three month(Total 24 months).
intervention type: Procedure
intervention name: RSD
description: Contrast renal angiography was performed to localize and assess the renal arteries for accessibility and appropriateness for RSD. Once the anatomy was deemed acceptable, the internally irrigated radiofrequency ablation catheter(Celcius Thermocool,Biosense Webster, Diamond Bar, California) was introduced into each renal artery. then was maneuvered within the renal artery to allow energy delivery in a circumferential, longitudinally staggered manner to minimize the chance of renal artery stenosis. About six to nine ablations at 10 W for 1 min each were performed in both renal arteries. During ablation, the catheter system monitored tip temperature and impedance, altering radiofrequency energy delivery in response to a predetermined algorithm.
arm group label: RSD+PCI+Medicine
other name: renal sympathetic denervation
other name: renal denervation
other name: renal ablation
intervention type: Procedure
intervention name: PCI
description: Percutaneous coronary intervention (PCI) is a non-surgical procedure used to treat the stenotic coronary arteries of the heart found in CHD. During PCI, a cardiologist feeds a deflated balloon or other device on a catheter from the inguinal femoral artery or radial artery up through blood vessels until they reach the site of blockage in the heart. X-ray imaging is used to guide the catheter threading. At the blockage, the balloon is inflated to open the artery, allowing blood to flow. A stent is often placed at the site of blockage to permanently open the artery.
arm group label: PCI+Medicine
arm group label: RSD+PCI+Medicine
other name: percutaneous coronary intervention
criteria: 
gender: All
minimum age: 18 Years
maximum age: 75 Years
healthy volunteers: No
last name: Qijun Shan, professor
role: Study Chair
affiliation: The First Affiliated Hospital with Nanjing Medical University
last name: Qijun Shan, professor
phone: 0086 025 68136407
email: qjshan@njmu.edu.cn
facility: 
status: Recruiting
investigator: 
investigator: 
investigator: 
investigator: 
investigator: 
investigator: 
investigator: 
investigator: 
investigator: 
country: China
responsible party type: Principal Investigator
investigator affiliation: The First Affiliated Hospital with Nanjing Medical University
investigator full name: Qijun Shan
investigator title: Professor，Director, Cardiac Arrhythmia Group
mesh term: Heart Diseases
mesh term: Coronary Disease
mesh term: Coronary Artery Disease
mesh term: Myocardial Ischemia