<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT01660659</url>
  </required_header>
  <id_info>
    <org_study_id>SCC 1284</org_study_id>
    <nct_id>NCT01660659</nct_id>
  </id_info>
  <brief_title>Indoor Air Pollution (IAP) Carriage Study</brief_title>
  <official_title>Use of Biomass Briquettes: Its Effect on Indoor Air Pollution and on Pneumococcal Nasopharyngeal Carriage. A Randomized Clinical Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>London School of Hygiene and Tropical Medicine</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>London School of Hygiene and Tropical Medicine</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      Personal exposure to Indoor Air Pollution (IAP) is a known risk factor of severe pneumonia,&#xD;
      which is the number one killer of children under five in developing countries. The main&#xD;
      source of IAP in developing countries is cooking fires, with an estimated 3 billion people&#xD;
      still reliant on biomass stoves for their daily cooking. This study will test the&#xD;
      effectiveness of an intervention aimed to reduce IAP, as well as help to quantify the&#xD;
      relationship between exposure (IAP) and infection (pneumococcal carriage).&#xD;
&#xD;
      In Phase I (adjunct pilot study L2010.99), 3 fuels and 5 stoves were tested to measure&#xD;
      harmful pollutant emissions. The preliminary results showed that the largest difference was&#xD;
      found in the fuels (briquettes cleaner than wood), with a smaller difference found between a&#xD;
      couple of the improved stoves and the traditional 3-stone. Re-testing of selected stove/fuel&#xD;
      combinations to confirm findings has just been completed. Phase II (this proposal) will test&#xD;
      the biomass briquettes in a randomized clinical trial to measure actual IAP reductions in&#xD;
      households. A proof of concept pneumococcal survey will also be conducted as a secondary&#xD;
      study to see whether reduced exposure to IAP affects pneumococcal carriage in babies and&#xD;
      mothers&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Acute respiratory infections (ARI), specifically Severe Pneumonia, are the leading cause of&#xD;
      death in children under 5 years of age. Of the nearly 10 million children under 5 who die&#xD;
      each year, 1.9 million die from ARI, almost all of which occur in developing countries [1,&#xD;
      2]. Over the years, various studies have identified many risk factors associated with ARI,&#xD;
      including malnutrition, zinc deficiency, indoor air pollution (IAP) from solid fuels and&#xD;
      tobacco. Proven efficacious interventions have been developed and studied to address risk&#xD;
      factors related to nutrition and zinc deficiency but still little is known about IAP and&#xD;
      proven effective interventions. Furthermore, little is known about the quantifiable&#xD;
      relationship between IAP exposure and disease, specifically ARI.&#xD;
&#xD;
      IAP from cooking with biomass is one of the top ten global health risks [3]. 1.6 million&#xD;
      people are estimated to die every year from IAP exposure, of which half of them are children&#xD;
      under 5 years of age [4]. In developing countries, IAP is estimated to account for 3.7% of&#xD;
      the total burden of disease, making it the fourth most serious health risk factor after&#xD;
      malnutrition, STDs, and inadequate water and sanitation [5]. A recent meta-analysis found&#xD;
      that children under 5 years old living in households using biomass fuels had a 78% greater&#xD;
      chance of contracting pneumonia than did children in households with cleaner-burning fuels&#xD;
      [6]. In Africa, 94% of the rural population and 73% of the urban population use solid fuels&#xD;
      as their primary source of energy [7]. Not only does IAP disproportionally affect the poor,&#xD;
      but it also affects women and children who spend more time near the cooking fires and are&#xD;
      therefore are most exposed.&#xD;
&#xD;
      Because of the difficulty in measuring exposure, most observational studies use proxy&#xD;
      measures. These proxies include the type of fuel used, amount of time spent near the cooking&#xD;
      fires, or whether the child is carried on the mother's back during cooking. But because&#xD;
      variations in personal exposure in most countries depend on a variety of factors (e.g. fuel,&#xD;
      stove, housing, behavioral), proxy indicators are an insufficient method to effectively&#xD;
      capture variations in exposure [8]. This affects the understanding and knowledge of the&#xD;
      potential health gains that might result from reducing exposure by varying amounts.&#xD;
      Determining this exposure-disease relationship is crucial to understanding the possible&#xD;
      impacts that interventions may have on improving health [9]. Unfortunately, the amount of&#xD;
      research being done on pollutant exposure from IAP is negligible compared to the huge disease&#xD;
      burden associated with this exposure [10]. A lot more research needs to be conducted to help&#xD;
      the lives of the 3 billion affected from these harmful pollutants.&#xD;
&#xD;
      Interventional Research Interventional research has focused on developing more efficient&#xD;
      biomass stoves as an approach to reduce IAP, yet few studies have looked into alternative&#xD;
      biomass fuels. Though improved stoves have shown to reduce pollutant emissions in controlled&#xD;
      settings, it remains difficult to measure the true effectiveness of this intervention, i.e.&#xD;
      whether these stoves are actually reducing pollutants in local kitchens. The Water Boiling&#xD;
      Test (WBT) and Controlled Cooking Tests (CCT), both of which are conducted in controlled&#xD;
      environments, are based on the assumption that performing a simple cooking task produces&#xD;
      estimates that can be used when evaluating technology for developing populations [11].&#xD;
      However, because of the numerous behavioral and outside variables that can alter the&#xD;
      efficiency of a stove, these tests do not illustrate the true picture of how the technology&#xD;
      will perform among the population [12]. The Kitchen Performance Test (KPT) has been designed&#xD;
      to measure the effectiveness though because of its difficulties in implementation, it is&#xD;
      often not used to measure stove performance. Furthermore, there have been varying results in&#xD;
      the field effectiveness of reducing IAP with improved stoves [9]. Given the wide variability&#xD;
      in stoves and settings, it remains difficult to know what levels of IAP exposure reductions&#xD;
      can be expected.&#xD;
&#xD;
      Because of the uncertainties and challenges of reducing IAP with improved stoves, other&#xD;
      interventions to reduce pollutant levels need to be explored, such as the use of alternative&#xD;
      biomass fuel in lieu of wood. A study in 2003 in rural Kenya looked at modelling potential&#xD;
      reductions on disease following interventions including fuel, stove type and cooking&#xD;
      location. This study showed that the largest reduction was from switching fuels and not&#xD;
      stoves [3]. There are a handful of studies throughout developing countries that are currently&#xD;
      looking at using crop waste as an alternative fuel. But because crop waste varies greatly&#xD;
      with locality, separate testing needs be done on these different crop wastes and their&#xD;
      transformation into cooking fuel. In The Gambia and most of West and Central Africa,&#xD;
      groundnuts are a major cash crop and their shells are available in abundance. Recently, two&#xD;
      separate factories have been established in The Gambia to process these dried groundnut&#xD;
      shells into biomass briquettes, which will then be used as cooking fuel. During Phase I of&#xD;
      this study, the investigators have tested (and are currently retesting) the two available&#xD;
      biomass briquettes made from groundnut shells. Both the WBT and CCT are being conducted to&#xD;
      evaluate the performance of these fuels (in comparison to wood and charcoal) when used with&#xD;
      different stoves, as well as IAP emissions. These tests were conducted in accordance with the&#xD;
      protocol developed for the Shell Foundation and Household Energy Health Program [13, 14]. The&#xD;
      investigators also concurrently measured PM2.5 concentrations two ways: continuous PM2.5&#xD;
      concentrations using light-scattering, TSI 8520 DustTrak monitors and integrated PM2.5&#xD;
      concentrations using gravimetric Casella pumps, cyclones, and Teflon filters. CO&#xD;
      concentrations were also measured alongside the CCT using Drager CO 50/a-D Diffusion Tubes.&#xD;
      The Investigators preliminary analysis shows that the briquettes do burn much cleaner than&#xD;
      wood when used with each of the tested stoves. The investigators are currently retesting the&#xD;
      briquettes with the different stoves to assure the investigators have the cleanest stove/fuel&#xD;
      combination for Phase II.&#xD;
&#xD;
      For Phase II (this proposal), the investigators will test the effectiveness of the biomass&#xD;
      briquettes in the communities. It is possible the investigators will also use an improved&#xD;
      stove with the briquettes, though this decision will not be made until the final analysis is&#xD;
      complete in December/January. However, based on the preliminary analysis, the investigators&#xD;
      are leaning more towards briquettes with the traditional 3-stone. For simplicity sake,&#xD;
      briquettes are mentioned as the intervention throughout this document. Though RCTs usually&#xD;
      measure the efficacy of an intervention, this study is slightly different in that the&#xD;
      efficiency and efficacy have already been conducted in Phase I. This study will enable the&#xD;
      investigators to evaluate the true reduction of IAP emissions in the study population, as&#xD;
      well as the cost effectiveness of using briquettes compared to wood or charcoal. From the&#xD;
      preliminary research, the investigators found that the briquettes performed very similarly to&#xD;
      wood, and therefore do not anticipate difficulties in adopting the use of briquettes.&#xD;
&#xD;
      Using pneumococcal carriage as a proxy measure for a health outcome Pneumonia accounts for&#xD;
      ~30% of deaths of children under the age of 5 in developing countries, most resulting from&#xD;
      Streptococcus pneumoniae (pneumococcus). Pneumococci generally colonizes the nasopharynx&#xD;
      within the first months of life, with carriage rates in children in developing countries 2-3&#xD;
      times higher than those found in children from developed countries[15, 16]. In one study in&#xD;
      The Gambia, it was found that pneumococcal carriage was greater than 80% during the third&#xD;
      month of life [17]. In another study in Bangladesh, it was found that 50% of the children had&#xD;
      been colonized by pneumococci at least once by the age of 8 weeks [18]. Though pneumococcal&#xD;
      carriage is present in many healthy people, it is an identifiable risk for disease,&#xD;
      predominantly affecting the young in developing countries.&#xD;
&#xD;
      Nasopharyngeal colonization is a necessary phase before infection with S pneumoniae can occur&#xD;
      [19]. Therefore, preventing colonization from ever happening can be an important measure to&#xD;
      preventing S pneumoniae. As IAP exposure is one major risk factor to developing ARI,&#xD;
      understanding how IAP exposure can affect the risk of infection for pneumococcal carriers can&#xD;
      help us better understand the quantitative relationship between IAP exposure and disease&#xD;
      (severe pneumonia). There have been previous studies looking at the impact tobacco smoke has&#xD;
      on carriage, but to date, there has yet to be any research done looking at carriage and IAP&#xD;
      exposure. This study may be instrumental in helping understand this complex exposure-disease&#xD;
      relationship. This component of the study is a Proof-of-Concept study, and is therefore&#xD;
      designed to illustrate the potential relationship between IAP exposure and ARI. If using&#xD;
      pneumococcal carriage as a proxy does show to be an effective tool in helping to quantify the&#xD;
      this relationship, it has the potential to lay the foundation for further research looking at&#xD;
      IAP and its affect on pneumococcal carriage.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date>January 2012</start_date>
  <completion_date type="Actual">August 2015</completion_date>
  <primary_completion_date type="Actual">June 2012</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Other</primary_purpose>
    <masking>Single (Investigator)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>IAP Carriage Study</measure>
    <time_frame>12 months</time_frame>
    <description>1. Integrated PM2.5 concentrations (48 hour measurements in each kitchen) Integrated PM2.5 concentrations will be measured using gravimetric Casella and SKC pumps, cyclones, and Teflon filters. The pumps will run one minute on, 5 minutes off, for 48 continuous hours in each of the participating cookhouses. These integrated measurements will allow us to compare the emissions from briquettes and firewood.&#xD;
The measurements will take place at a random time during the 16 week invention period</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>IAP Carriage Study</measure>
    <time_frame>12 months</time_frame>
    <description>To measure the prevalence of pneumococcal carriage in both study arms. These surveys will occur at the start of the study (before the intervention) to capture the baseline measurement, and at the end of the study (after the 16 weeks of intervention), to see whether reduced exposure to PMs affects pneumococcal carriage in the mothers and babies</description>
  </secondary_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">500</enrollment>
  <condition>Pneumococcal Carriage</condition>
  <condition>Particulate Matter</condition>
  <arm_group>
    <arm_group_label>cooking with Biomass Briquettes and Rocket Stove</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>cooking with Biomass Briquettes and Rocket Stove</description>
  </arm_group>
  <arm_group>
    <arm_group_label>standard cooking</arm_group_label>
    <arm_group_type>No Intervention</arm_group_type>
    <description>standard way of cooking</description>
  </arm_group>
  <intervention>
    <intervention_type>Device</intervention_type>
    <intervention_name>Biomass Briquettes and Rocket stove</intervention_name>
    <description>Biomass briquettes are made from dried peanut shells. Rocket stoves were designed to efficiently burn the briquettes</description>
    <arm_group_label>cooking with Biomass Briquettes and Rocket Stove</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Child between 2 to 8 months of age at start of the study (1st pneumococcal swab)&#xD;
&#xD;
          -  residing within the catchment area&#xD;
&#xD;
          -  the mother relies only on wood and the 3-stone stove for all her cooking&#xD;
&#xD;
          -  the mother will cook in an indoor kitchen only (not outside; 4 walls with a roof)&#xD;
&#xD;
          -  written informed consent&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  will be traveling from their home during the following 6 months&#xD;
&#xD;
          -  already involved in another study&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>2 Months</minimum_age>
    <maximum_age>8 Months</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Teresa Litchfield</last_name>
    <role>Principal Investigator</role>
    <affiliation>Medical Research Council Unit, The Gambia</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Medical Research Council Unit</name>
      <address>
        <city>Fajara</city>
        <country>Gambia</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Gambia</country>
  </location_countries>
  <verification_date>May 2018</verification_date>
  <study_first_submitted>May 18, 2012</study_first_submitted>
  <study_first_submitted_qc>August 6, 2012</study_first_submitted_qc>
  <study_first_posted type="Estimate">August 9, 2012</study_first_posted>
  <last_update_submitted>May 29, 2018</last_update_submitted>
  <last_update_submitted_qc>May 29, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">May 31, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Indoor air pollution</keyword>
  <keyword>pneumococcal carriage</keyword>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT01660659
org study id: SCC 1284
nct id: NCT01660659
lead sponsor: 
has dmc: No
Personal exposure to Indoor Air Pollution (IAP) is a known risk factor of severe pneumonia,
      which is the number one killer of children under five in developing countries. The main
      source of IAP in developing countries is cooking fires, with an estimated 3 billion people
      still reliant on biomass stoves for their daily cooking. This study will test the
      effectiveness of an intervention aimed to reduce IAP, as well as help to quantify the
      relationship between exposure (IAP) and infection (pneumococcal carriage).

      In Phase I (adjunct pilot study L2010.99), 3 fuels and 5 stoves were tested to measure
      harmful pollutant emissions. The preliminary results showed that the largest difference was
      found in the fuels (briquettes cleaner than wood), with a smaller difference found between a
      couple of the improved stoves and the traditional 3-stone. Re-testing of selected stove/fuel
      combinations to confirm findings has just been completed. Phase II (this proposal) will test
      the biomass briquettes in a randomized clinical trial to measure actual IAP reductions in
      households. A proof of concept pneumococcal survey will also be conducted as a secondary
      study to see whether reduced exposure to IAP affects pneumococcal carriage in babies and
      mothers
Acute respiratory infections (ARI), specifically Severe Pneumonia, are the leading cause of
      death in children under 5 years of age. Of the nearly 10 million children under 5 who die
      each year, 1.9 million die from ARI, almost all of which occur in developing countries [1,
      2]. Over the years, various studies have identified many risk factors associated with ARI,
      including malnutrition, zinc deficiency, indoor air pollution (IAP) from solid fuels and
      tobacco. Proven efficacious interventions have been developed and studied to address risk
      factors related to nutrition and zinc deficiency but still little is known about IAP and
      proven effective interventions. Furthermore, little is known about the quantifiable
      relationship between IAP exposure and disease, specifically ARI.

      IAP from cooking with biomass is one of the top ten global health risks [3]. 1.6 million
      people are estimated to die every year from IAP exposure, of which half of them are children
      under 5 years of age [4]. In developing countries, IAP is estimated to account for 3.7% of
      the total burden of disease, making it the fourth most serious health risk factor after
      malnutrition, STDs, and inadequate water and sanitation [5]. A recent meta-analysis found
      that children under 5 years old living in households using biomass fuels had a 78% greater
      chance of contracting pneumonia than did children in households with cleaner-burning fuels
      [6]. In Africa, 94% of the rural population and 73% of the urban population use solid fuels
      as their primary source of energy [7]. Not only does IAP disproportionally affect the poor,
      but it also affects women and children who spend more time near the cooking fires and are
      therefore are most exposed.

      Because of the difficulty in measuring exposure, most observational studies use proxy
      measures. These proxies include the type of fuel used, amount of time spent near the cooking
      fires, or whether the child is carried on the mother's back during cooking. But because
      variations in personal exposure in most countries depend on a variety of factors (e.g. fuel,
      stove, housing, behavioral), proxy indicators are an insufficient method to effectively
      capture variations in exposure [8]. This affects the understanding and knowledge of the
      potential health gains that might result from reducing exposure by varying amounts.
      Determining this exposure-disease relationship is crucial to understanding the possible
      impacts that interventions may have on improving health [9]. Unfortunately, the amount of
      research being done on pollutant exposure from IAP is negligible compared to the huge disease
      burden associated with this exposure [10]. A lot more research needs to be conducted to help
      the lives of the 3 billion affected from these harmful pollutants.

      Interventional Research Interventional research has focused on developing more efficient
      biomass stoves as an approach to reduce IAP, yet few studies have looked into alternative
      biomass fuels. Though improved stoves have shown to reduce pollutant emissions in controlled
      settings, it remains difficult to measure the true effectiveness of this intervention, i.e.
      whether these stoves are actually reducing pollutants in local kitchens. The Water Boiling
      Test (WBT) and Controlled Cooking Tests (CCT), both of which are conducted in controlled
      environments, are based on the assumption that performing a simple cooking task produces
      estimates that can be used when evaluating technology for developing populations [11].
      However, because of the numerous behavioral and outside variables that can alter the
      efficiency of a stove, these tests do not illustrate the true picture of how the technology
      will perform among the population [12]. The Kitchen Performance Test (KPT) has been designed
      to measure the effectiveness though because of its difficulties in implementation, it is
      often not used to measure stove performance. Furthermore, there have been varying results in
      the field effectiveness of reducing IAP with improved stoves [9]. Given the wide variability
      in stoves and settings, it remains difficult to know what levels of IAP exposure reductions
      can be expected.

      Because of the uncertainties and challenges of reducing IAP with improved stoves, other
      interventions to reduce pollutant levels need to be explored, such as the use of alternative
      biomass fuel in lieu of wood. A study in 2003 in rural Kenya looked at modelling potential
      reductions on disease following interventions including fuel, stove type and cooking
      location. This study showed that the largest reduction was from switching fuels and not
      stoves [3]. There are a handful of studies throughout developing countries that are currently
      looking at using crop waste as an alternative fuel. But because crop waste varies greatly
      with locality, separate testing needs be done on these different crop wastes and their
      transformation into cooking fuel. In The Gambia and most of West and Central Africa,
      groundnuts are a major cash crop and their shells are available in abundance. Recently, two
      separate factories have been established in The Gambia to process these dried groundnut
      shells into biomass briquettes, which will then be used as cooking fuel. During Phase I of
      this study, the investigators have tested (and are currently retesting) the two available
      biomass briquettes made from groundnut shells. Both the WBT and CCT are being conducted to
      evaluate the performance of these fuels (in comparison to wood and charcoal) when used with
      different stoves, as well as IAP emissions. These tests were conducted in accordance with the
      protocol developed for the Shell Foundation and Household Energy Health Program [13, 14]. The
      investigators also concurrently measured PM2.5 concentrations two ways: continuous PM2.5
      concentrations using light-scattering, TSI 8520 DustTrak monitors and integrated PM2.5
      concentrations using gravimetric Casella pumps, cyclones, and Teflon filters. CO
      concentrations were also measured alongside the CCT using Drager CO 50/a-D Diffusion Tubes.
      The Investigators preliminary analysis shows that the briquettes do burn much cleaner than
      wood when used with each of the tested stoves. The investigators are currently retesting the
      briquettes with the different stoves to assure the investigators have the cleanest stove/fuel
      combination for Phase II.

      For Phase II (this proposal), the investigators will test the effectiveness of the biomass
      briquettes in the communities. It is possible the investigators will also use an improved
      stove with the briquettes, though this decision will not be made until the final analysis is
      complete in December/January. However, based on the preliminary analysis, the investigators
      are leaning more towards briquettes with the traditional 3-stone. For simplicity sake,
      briquettes are mentioned as the intervention throughout this document. Though RCTs usually
      measure the efficacy of an intervention, this study is slightly different in that the
      efficiency and efficacy have already been conducted in Phase I. This study will enable the
      investigators to evaluate the true reduction of IAP emissions in the study population, as
      well as the cost effectiveness of using briquettes compared to wood or charcoal. From the
      preliminary research, the investigators found that the briquettes performed very similarly to
      wood, and therefore do not anticipate difficulties in adopting the use of briquettes.

      Using pneumococcal carriage as a proxy measure for a health outcome Pneumonia accounts for
      ~30% of deaths of children under the age of 5 in developing countries, most resulting from
      Streptococcus pneumoniae (pneumococcus). Pneumococci generally colonizes the nasopharynx
      within the first months of life, with carriage rates in children in developing countries 2-3
      times higher than those found in children from developed countries[15, 16]. In one study in
      The Gambia, it was found that pneumococcal carriage was greater than 80% during the third
      month of life [17]. In another study in Bangladesh, it was found that 50% of the children had
      been colonized by pneumococci at least once by the age of 8 weeks [18]. Though pneumococcal
      carriage is present in many healthy people, it is an identifiable risk for disease,
      predominantly affecting the young in developing countries.

      Nasopharyngeal colonization is a necessary phase before infection with S pneumoniae can occur
      [19]. Therefore, preventing colonization from ever happening can be an important measure to
      preventing S pneumoniae. As IAP exposure is one major risk factor to developing ARI,
      understanding how IAP exposure can affect the risk of infection for pneumococcal carriers can
      help us better understand the quantitative relationship between IAP exposure and disease
      (severe pneumonia). There have been previous studies looking at the impact tobacco smoke has
      on carriage, but to date, there has yet to be any research done looking at carriage and IAP
      exposure. This study may be instrumental in helping understand this complex exposure-disease
      relationship. This component of the study is a Proof-of-Concept study, and is therefore
      designed to illustrate the potential relationship between IAP exposure and ARI. If using
      pneumococcal carriage as a proxy does show to be an effective tool in helping to quantify the
      this relationship, it has the potential to lay the foundation for further research looking at
      IAP and its affect on pneumococcal carriage.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Other
masking: Single (Investigator)
measure: IAP Carriage Study
time frame: 12 months
description: 1. Integrated PM2.5 concentrations (48 hour measurements in each kitchen) Integrated PM2.5 concentrations will be measured using gravimetric Casella and SKC pumps, cyclones, and Teflon filters. The pumps will run one minute on, 5 minutes off, for 48 continuous hours in each of the participating cookhouses. These integrated measurements will allow us to compare the emissions from briquettes and firewood.
The measurements will take place at a random time during the 16 week invention period
measure: IAP Carriage Study
time frame: 12 months
description: To measure the prevalence of pneumococcal carriage in both study arms. These surveys will occur at the start of the study (before the intervention) to capture the baseline measurement, and at the end of the study (after the 16 weeks of intervention), to see whether reduced exposure to PMs affects pneumococcal carriage in the mothers and babies
arm group label: cooking with Biomass Briquettes and Rocket Stove
arm group type: Experimental
description: cooking with Biomass Briquettes and Rocket Stove
arm group label: standard cooking
arm group type: No Intervention
description: standard way of cooking
intervention type: Device
intervention name: Biomass Briquettes and Rocket stove
description: Biomass briquettes are made from dried peanut shells. Rocket stoves were designed to efficiently burn the briquettes
arm group label: cooking with Biomass Briquettes and Rocket Stove
criteria: 
gender: All
minimum age: 2 Months
maximum age: 8 Months
healthy volunteers: Accepts Healthy Volunteers
last name: Teresa Litchfield
role: Principal Investigator
affiliation: Medical Research Council Unit, The Gambia
facility: 
country: Gambia
responsible party type: Sponsor