<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT01719393</url>
  </required_header>
  <id_info>
    <org_study_id>201207062RIC</org_study_id>
    <nct_id>NCT01719393</nct_id>
  </id_info>
  <brief_title>Pulse Spectrum Analysis in Adult Asthmatics: Correlation With Lung Function, Asthma Control Exhaled Nitric Oxide and Metabolites in Exhaled Breath Condensate</brief_title>
  <official_title>Pulse Spectrum Analysis in Adult Asthmatics: Correlation With Lung Function, Asthma Control Exhaled Nitric Oxide and Metabolites in Exhaled Breath</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>National Taiwan University Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>National Taiwan University Hospital</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      Our hypothesis is that radial arterial pulse may reflect the severity and airway function in&#xD;
      asthmatics. The aims of this study are to investigate the pulse spectrim of the radial artery&#xD;
      in adult asthmatics, and evaluate its correlation with airy inflammation an lung funtion in&#xD;
      asthmatics.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      The microcirculation is directly involved in the cellular matabolism and homeostasis. Our&#xD;
      hypothesis is that radial arterial pulse spectrum may reflect the airway condition in&#xD;
      asthmatics. The aims of this study are to investigate the pulse spectrim of the radial artery&#xD;
      in adult asthmatics, and evaluate its correlation with lung function, asthma control&#xD;
      status,exhaled nitric oxide, and metabolites in the exhaed breath condensates.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Not yet recruiting</last_known_status>
  <start_date>November 2012</start_date>
  <completion_date type="Anticipated">December 2013</completion_date>
  <primary_completion_date type="Anticipated">November 2013</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Control</observational_model>
    <time_perspective>Prospective</time_perspective>
  </study_design_info>
  <primary_outcome>
    <measure>Pulse spectral analysis</measure>
    <time_frame>one year</time_frame>
  </primary_outcome>
  <enrollment type="Anticipated">100</enrollment>
  <condition>Pulse Spectrum Analysis</condition>
  <condition>Pulmonary Function</condition>
  <condition>FeNO</condition>
  <condition>Metabolites</condition>
  <biospec_retention>Samples Without DNA</biospec_retention>
  <biospec_descr>
    <textblock>
      Exhaled brath condensate&#xD;
    </textblock>
  </biospec_descr>
  <eligibility>
    <study_pop>
      <textblock>
        Asthma paitients&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Non-Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Meet the diagnostic criteria of GINA guideline asthma patients&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Cancer or immune impaired patients;&#xD;
&#xD;
          -  pack-year smoking&gt; 5;&#xD;
&#xD;
          -  long-term ventilator-dependent patients&#xD;
&#xD;
          -  Control group: 30 age matched healthy controls&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>20 Years</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Ping-Hung Kuo</last_name>
    <role>Principal Investigator</role>
    <affiliation>National Taiwan University Hospital</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Ping-Hung Kuo</last_name>
    <phone>886-2-23123456</phone>
    <phone_ext>63075</phone_ext>
    <email>kph712@ntuh.gov.tw</email>
  </overall_contact>
  <location>
    <facility>
      <name>National Taiwan University Hospital</name>
      <address>
        <city>Taipei</city>
        <country>Taiwan</country>
      </address>
    </facility>
    <contact>
      <last_name>Ping-Hung Kuo</last_name>
      <phone>886-2-23123456</phone>
      <phone_ext>63075</phone_ext>
      <email>kph712@ntuh.gov.tw</email>
    </contact>
  </location>
  <location_countries>
    <country>Taiwan</country>
  </location_countries>
  <verification_date>October 2012</verification_date>
  <study_first_submitted>October 30, 2012</study_first_submitted>
  <study_first_submitted_qc>October 31, 2012</study_first_submitted_qc>
  <study_first_posted type="Estimate">November 1, 2012</study_first_posted>
  <last_update_submitted>October 31, 2012</last_update_submitted>
  <last_update_submitted_qc>October 31, 2012</last_update_submitted_qc>
  <last_update_posted type="Estimate">November 1, 2012</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor-Investigator</responsible_party_type>
    <investigator_affiliation>National Taiwan University Hospital</investigator_affiliation>
    <investigator_full_name>National Taiwan University Hospital</investigator_full_name>
    <investigator_title>M.D.</investigator_title>
  </responsible_party>
  <keyword>Asthma</keyword>
  <keyword>Pulse spectrum analysis</keyword>
  <keyword>lung function</keyword>
  <keyword>exhaled nitric oxide</keyword>
  <keyword>metabolites</keyword>
  <keyword>exhaled breath condensate</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Asthma</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT01719393
org study id: 201207062RIC
nct id: NCT01719393
lead sponsor: 
has dmc: No
Our hypothesis is that radial arterial pulse may reflect the severity and airway function in
      asthmatics. The aims of this study are to investigate the pulse spectrim of the radial artery
      in adult asthmatics, and evaluate its correlation with airy inflammation an lung funtion in
      asthmatics.
The microcirculation is directly involved in the cellular matabolism and homeostasis. Our
      hypothesis is that radial arterial pulse spectrum may reflect the airway condition in
      asthmatics. The aims of this study are to investigate the pulse spectrim of the radial artery
      in adult asthmatics, and evaluate its correlation with lung function, asthma control
      status,exhaled nitric oxide, and metabolites in the exhaed breath condensates.
observational model: Case-Control
time perspective: Prospective
measure: Pulse spectral analysis
time frame: one year
Exhaled brath condensate
study pop: 
sampling method: Non-Probability Sample
criteria: 
gender: All
minimum age: 20 Years
maximum age: N/A
healthy volunteers: Accepts Healthy Volunteers
last name: Ping-Hung Kuo
role: Principal Investigator
affiliation: National Taiwan University Hospital
last name: Ping-Hung Kuo
phone: 886-2-23123456
phone ext: 63075
email: kph712@ntuh.gov.tw
facility: 
contact: 
country: Taiwan
responsible party type: Sponsor-Investigator
investigator affiliation: National Taiwan University Hospital
investigator full name: National Taiwan University Hospital
investigator title: M.D.
mesh term: Asthma