<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT01731314</url>
  </required_header>
  <id_info>
    <org_study_id>2012P002386</org_study_id>
    <nct_id>NCT01731314</nct_id>
  </id_info>
  <brief_title>The Learning and Memory of the Experience of Pain</brief_title>
  <sponsors>
    <lead_sponsor>
      <agency>Massachusetts General Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Massachusetts General Hospital</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      This study investigates the learning and memory of pain.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Completed</overall_status>
  <start_date>January 2013</start_date>
  <completion_date type="Actual">January 2018</completion_date>
  <primary_completion_date type="Actual">January 2018</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Single Group Assignment</intervention_model>
    <primary_purpose>Other</primary_purpose>
    <masking>Single (Participant)</masking>
  </study_design_info>
  <enrollment type="Anticipated">60</enrollment>
  <condition>Pain</condition>
  <intervention>
    <intervention_type>Behavioral</intervention_type>
    <intervention_name>Learning and Memory of Pain</intervention_name>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          1. Male and female healthy volunteers.&#xD;
&#xD;
          2. 18-65 years of age.&#xD;
&#xD;
          3. Right-handed.&#xD;
&#xD;
          4. Fluency in English. Ability to read and understand English; English can be a second&#xD;
             language provided that the participant feels that he/she is able to understand all the&#xD;
             questions used in the assessment measures.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          1. Any previous experience with conditioned analgesia/hyperalgesia paradigms.&#xD;
&#xD;
          2. Presence of any illness or medication use that is judged to interfere with the trial.&#xD;
             For example: psychiatric disorder according to the DSM-IV manual, medication that can&#xD;
             influence cognition or emotional processing, i.e. sleep medication, antidepressants,&#xD;
             anti-convulsants or opioids.&#xD;
&#xD;
          3. Unwillingness to receive brief pain stimulation administered by a heat probe on the&#xD;
             hand.&#xD;
&#xD;
          4. Instability of responses to experimental heat pain&#xD;
&#xD;
          5. Any contraindications to fMRI scanning for subjects in Experiment 2 (including metal&#xD;
             implants, claustrophobia, history of head trauma, and pregnancy).&#xD;
&#xD;
          6. Peripheral neuropathy.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>65 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <location>
    <facility>
      <name>MGH East Campus, 149 13th St.</name>
      <address>
        <city>Charlestown</city>
        <state>Massachusetts</state>
        <zip>02129</zip>
        <country>United States</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>United States</country>
  </location_countries>
  <verification_date>August 2019</verification_date>
  <study_first_submitted>November 16, 2012</study_first_submitted>
  <study_first_submitted_qc>November 16, 2012</study_first_submitted_qc>
  <study_first_posted type="Estimate">November 21, 2012</study_first_posted>
  <last_update_submitted>August 12, 2019</last_update_submitted>
  <last_update_submitted_qc>August 12, 2019</last_update_submitted_qc>
  <last_update_posted type="Actual">August 13, 2019</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Massachusetts General Hospital</investigator_affiliation>
    <investigator_full_name>Jian Kong</investigator_full_name>
    <investigator_title>MS, MD</investigator_title>
  </responsible_party>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT01731314
org study id: 2012P002386
nct id: NCT01731314
lead sponsor: 
has dmc: No
This study investigates the learning and memory of pain.
allocation: Randomized
intervention model: Single Group Assignment
primary purpose: Other
masking: Single (Participant)
intervention type: Behavioral
intervention name: Learning and Memory of Pain
criteria: 
gender: All
minimum age: 18 Years
maximum age: 65 Years
healthy volunteers: Accepts Healthy Volunteers
facility: 
country: United States
responsible party type: Principal Investigator
investigator affiliation: Massachusetts General Hospital
investigator full name: Jian Kong
investigator title: MS, MD