<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT01734603</url>
  </required_header>
  <id_info>
    <org_study_id>DCIC 12</org_study_id>
    <nct_id>NCT01734603</nct_id>
  </id_info>
  <brief_title>Intensive Rehabilitation in Peripheral Arterial Disease With Claudication: Effects of a Treadmill Training With Active Recovery</brief_title>
  <acronym>ARTEX</acronym>
  <official_title>Randomized, Monocentric and Multidisciplinary Study of the Effects of an Intensive Rehabilitation by Interval Training With Active Recovery in Peripheral Arterial Disease With Claudication</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>University Hospital, Grenoble</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>University Hospital, Grenoble</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      Rehabilitation is the first intention treatment of peripheral arterial disease (PAD) with&#xD;
      claudication. Initially proposed in the sixty's, rehabilitation programs dedicated to&#xD;
      patients with PAD have recently been proved effective and defined in many guidelines.&#xD;
      Supervised walking training on treadmill is recommended. Usually patients walk up to a mild&#xD;
      or moderate pain (evaluated at 3 or 4 on the claudication pain scale; maximum pain =5), then&#xD;
      stop until pain completely subsides and walk again .&#xD;
&#xD;
      The Artex study assesses the efficacy of a fractionated mode of training avoiding pain by&#xD;
      alternating short sequences of intensive training and active recovery (without rest).&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Fractionated mode of training with active recovery has been proved effective in sport&#xD;
      training as well as in Cardiac rehabilitation. We hypothesized it might be also interesting&#xD;
      in the rehabilitation of patients with a peripheral arterial disease. The active recovery&#xD;
      period might magnified the beneficial effect of a short intensive training.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Completed</overall_status>
  <start_date>October 2011</start_date>
  <completion_date type="Actual">September 2014</completion_date>
  <primary_completion_date type="Actual">May 2014</primary_completion_date>
  <phase>Phase 3</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>None (Open Label)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Intensive Rehabilitation in Peripheral Arterial Disease with Claudication: effects of a treadmill training with active recovery</measure>
    <time_frame>Between day 0 and day 28</time_frame>
    <description>Change in walking distance between day 0 and day 28, measured on a graded treadmill test</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Determine vascular and respiratory parameters which participate to improve the walking abilities after rehabilitation.</measure>
    <time_frame>Between day 0 and day 28</time_frame>
    <description>Change in walking distance between day 0 and day 28, measured with the 6 MWT and the Strandness test.&#xD;
Measure of ABI(Ankle-to- Brachial systolic blood pressure Index) and recovery time&#xD;
Measure of the transcutaneous oxygen pression&#xD;
Measure of the maximal cardiac frequency&#xD;
Measure of peak oxygen consumption and lactatemy</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Determine vascular and respiratory parameters which participate to improve the walking abilities after rehabilitation.</measure>
    <time_frame>Between day 0 and day 28</time_frame>
    <description>Measure of ABI(Ankle-to- Brachial systolic blood pressure Index) and recovery time&#xD;
Measure of the transcutaneous oxygen pression&#xD;
Measure of the maximal cardiac frequency&#xD;
Measure of peak oxygen consumption and lactatemy</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>One year follow-up</measure>
    <time_frame>one year</time_frame>
    <description>All patients included are invited to be assessed at a one year. Interview, Clinical Examination, and Assessemnts are performed in day hospital (half a day).&#xD;
Criteria are:&#xD;
Patients 'satisfaction about protocole using an ad hoc ordinal scale Medical and duplex scan examinations Vascular risk factors and comorbidities Occurence of any medical event during the year Changes in WIQ and HADS changes in walking distance at the Graduated Treadmill Test.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Reproducibility test of the walking graduated treadmill</measure>
    <time_frame>Day 0 et day 1</time_frame>
    <description>The fifteen last patients are invited to perform the consecutive graduated treadmill test on day 0 et day 1. Reproducibility of the walking distance assess by this novel test is quantified.</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Handicap and Depression measures</measure>
    <time_frame>Between day 0 and day 28</time_frame>
    <description>Walking Impairment Questionary WIQ&#xD;
Hospital Anxiety and Depression Scale HADS</description>
  </other_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">40</enrollment>
  <condition>Peripheral Arterial Disease</condition>
  <condition>Claudication</condition>
  <arm_group>
    <arm_group_label>conventional rehabilitation program</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>conventional rehabilitation program 20 patients are expected in this arm. Patients perform walking treadmill exercises with complete rest.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>experimental rehabilitation program</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>experimental rehabilitation program 20 patients are expected in this arm. Patients perform walking treadmill exercises with active recovery (no stop walking).</description>
  </arm_group>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>experimental rehabilitation program</intervention_name>
    <description>Duration training = 40 min : 5 cycles of 6 min each Week 1 speed of the walking exercise fixed at 70% of the max walking test's speed done on the initial walking test speed of the walking recovery fixed at 40% Walking slope : 0% Increase of the speed = 0.1 km/h after each training without pain.&#xD;
Week 2 Walking speed = average of the walking speeds done on week 1 Walking slope = 1% Recovery slope = 0% Increase of the slope = 0.5% after each training without pain.&#xD;
Week 3 Walking speed = 70% of the maximal walking test's speed Recovery speed = 40 % of the maximal walking test's speed Slope = average of the slopes done on week 2 Increase of the speed = 0.1 km/h .&#xD;
Week 4 Speeds = average of the walking speeds done on week 3 Walking slope = 1% Recovery slope = 0% Increase of the slope is 0.5% .</description>
    <arm_group_label>experimental rehabilitation program</arm_group_label>
  </intervention>
  <intervention>
    <intervention_type>Procedure</intervention_type>
    <intervention_name>conventional rehabilitation program</intervention_name>
    <description>Duration of the training 40 minutes (time excluding rest and warm up)&#xD;
Initial intensity = 3.2 km per hour and slope at 0% Walking until pain 3/5, then stop until pain completely subsides.Resume of walking as soon as possible.&#xD;
Increase :&#xD;
Week 1: if the walking is possible during 8 minutes, increase of the slope of 0.5% in each training until 10% Week 2 :if the walking is possible during 8 minutes, increase of the speed 0.2 mile per hour until 3 mph Week 3 :if the walking is possible during 8 minutes, increase of the slope 2% at each training until 15% Week 4 : if the walking is possible during 8 minutes, increase the speed 0.2mph at each training as long as it is possible.</description>
    <arm_group_label>conventional rehabilitation program</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Patient (male/female) between 18 and 80 years&#xD;
&#xD;
          -  Patient with Fontaine stage II PAD confirmed by clinic, duplex ultrasound and&#xD;
             ankle-to-brachial systolic blood pressure index&#xD;
&#xD;
          -  Cardiac status compatible with an intensive gait rehabilitation (checked by a&#xD;
             consultation with a cardiologist, including interview, clinical examination,&#xD;
             electrocardiograph, and effort test on ergocycle).&#xD;
&#xD;
          -  Volunteer to take part in the study, having sign the consent form after receiving&#xD;
             sufficient information and the information leaflet&#xD;
&#xD;
          -  Person affiliated to social security or the recipient of a similar scheme&#xD;
&#xD;
        Not Inclusion Criteria:&#xD;
&#xD;
          -  Exercise tolerance limited by other factors than claudication (eg, coronary artery&#xD;
             disease, dyspnea, poorly controlled blood pressure&#xD;
&#xD;
          -  walking limited by other pathology&#xD;
&#xD;
          -  osteoarticular lower limbs pathology&#xD;
&#xD;
          -  abdominal aortic aneurysm &gt; 4 cm&#xD;
&#xD;
          -  pseudo-flu-like feverish syndromes in evolution (myocarditis or pericarditis)&#xD;
&#xD;
          -  Person deprived of liberty by a legal or administrative decision, person under legal&#xD;
             protection&#xD;
&#xD;
          -  Person currently participating in a clinical trial or having taken part in a clinical&#xD;
             trial in the month preceding inclusion&#xD;
&#xD;
          -  Patient presenting with a history of mental or psychiatric illness or any other factor&#xD;
             restricting his/her ability to participate in an informed manner and in compliance&#xD;
             with the protocol&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
        Impossibility to perform protocol whatever reason&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>80 Years</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Béatrice VILLEMUR, MD</last_name>
    <role>Principal Investigator</role>
    <affiliation>Unité de rééducation vasculaire - Clinique médecine physique de rééducation - CHU Grenoble - Hôpital Sud</affiliation>
  </overall_official>
  <overall_official>
    <last_name>Dominic Perennou, MD, PhD</last_name>
    <role>Study Chair</role>
    <affiliation>Rehabilitation Department, Universitary Hospital Grenoble</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>CHU Grenoble - Hôpital Sud - Clinique médecine physique de rééducation</name>
      <address>
        <city>Echirolles</city>
        <zip>38434</zip>
        <country>France</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>France</country>
  </location_countries>
  <reference>
    <citation>Villemur B, Marquer A, Gailledrat E, Benetreau C, Bucci B, Evra V, Rabeau V, De Angelis MP, Bouchet JY, Carpentier P, Perennou D. New rehabilitation program for intermittent claudication: Interval training with active recovery: pilot study. Ann Phys Rehabil Med. 2011 Jul;54(5):275-81. doi: 10.1016/j.rehab.2011.05.003. Epub 2011 Jun 12. English, French.</citation>
    <PMID>21704582</PMID>
  </reference>
  <reference>
    <citation>Tisi PV, Hulse M, Chulakadabba A, Gosling P, Shearman CP. Exercise training for intermittent claudication: does it adversely affect biochemical markers of the exercise-induced inflammatory response? Eur J Vasc Endovasc Surg. 1997 Nov;14(5):344-50. doi: 10.1016/s1078-5884(97)80283-3.</citation>
    <PMID>9413374</PMID>
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    <citation>Strandness DE Jr. Exercise testing in the evaluation of patients undergoint direct arterial surgery. J Cardiovasc Surg (Torino). 1970 May-Jun;11(3):192-200. No abstract available.</citation>
    <PMID>5470199</PMID>
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    <citation>Snaith RP. The Hospital Anxiety And Depression Scale. Health Qual Life Outcomes. 2003 Aug 1;1:29. doi: 10.1186/1477-7525-1-29.</citation>
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  <reference>
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    <citation>McDermott MM, Ades P, Guralnik JM, Dyer A, Ferrucci L, Liu K, Nelson M, Lloyd-Jones D, Van Horn L, Garside D, Kibbe M, Domanchuk K, Stein JH, Liao Y, Tao H, Green D, Pearce WH, Schneider JR, McPherson D, Laing ST, McCarthy WJ, Shroff A, Criqui MH. Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication: a randomized controlled trial. JAMA. 2009 Jan 14;301(2):165-74. doi: 10.1001/jama.2008.962. Erratum In: JAMA. 2012 Apr 25;307(16):1694.</citation>
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    <citation>Le Faucheur A, Abraham P, Jaquinandi V, Bouye P, Saumet JL, Noury-Desvaux B. Measurement of walking distance and speed in patients with peripheral arterial disease: a novel method using a global positioning system. Circulation. 2008 Feb 19;117(7):897-904. doi: 10.1161/CIRCULATIONAHA.107.725994. Epub 2008 Feb 4.</citation>
    <PMID>18250268</PMID>
  </reference>
  <reference>
    <citation>Lechat P, Priollet P. [Prevention of major ischemic events in lower limb arterial disease: does aspirin play a role?]. J Mal Vasc. 2006 Jul;31(3):129-34. doi: 10.1016/s0398-0499(06)76531-3. French.</citation>
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    <citation>Kruidenier LM, Nicolai SP, Hendriks EJ, Bollen EC, Prins MH, Teijink JA. Supervised exercise therapy for intermittent claudication in daily practice. J Vasc Surg. 2009 Feb;49(2):363-70. doi: 10.1016/j.jvs.2008.09.042. Epub 2008 Nov 22.</citation>
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    <citation>Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL, Hiratzka LF, Murphy WR, Olin JW, Puschett JB, Rosenfield KA, Sacks D, Stanley JC, Taylor LM Jr, White CJ, White J, White RA, Antman EM, Smith SC Jr, Adams CD, Anderson JL, Faxon DP, Fuster V, Gibbons RJ, Hunt SA, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B; American Association for Vascular Surgery; Society for Vascular Surgery; Society for Cardiovascular Angiography and Interventions; Society for Vascular Medicine and Biology; Society of Interventional Radiology; ACC/AHA Task Force on Practice Guidelines Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease; American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; Vascular Disease Foundation. ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. Circulation. 2006 Mar 21;113(11):e463-654. doi: 10.1161/CIRCULATIONAHA.106.174526. No abstract available.</citation>
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    <citation>Gardner AW, Poehlman ET. Assessment of free-living daily physical activity in older claudicants: validation against the doubly labeled water technique. J Gerontol A Biol Sci Med Sci. 1998 Jul;53(4):M275-80. doi: 10.1093/gerona/53a.4.m275.</citation>
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    <citation>Bruce RA, Kusumi F, Hosmer D. Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am Heart J. 1973 Apr;85(4):546-62. doi: 10.1016/0002-8703(73)90502-4. No abstract available.</citation>
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    <citation>Bronas UG, Hirsch AT, Murphy T, Badenhop D, Collins TC, Ehrman JK, Ershow AG, Lewis B, Treat-Jacobson DJ, Walsh ME, Oldenburg N, Regensteiner JG; CLEVER Research Group. Design of the multicenter standardized supervised exercise training intervention for the claudication: exercise vs endoluminal revascularization (CLEVER) study. Vasc Med. 2009 Nov;14(4):313-21. doi: 10.1177/1358863X09102295.</citation>
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    <citation>Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002 Feb;52(2):69-77. doi: 10.1016/s0022-3999(01)00296-3.</citation>
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    <citation>Baker JD, Dix DE. Variability of Doppler ankle pressures with arterial occlusive disease: an evaluation of ankle index and brachial-ankle pressure gradient. Surgery. 1981 Jan;89(1):134-7.</citation>
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    <citation>ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7. doi: 10.1164/ajrccm.166.1.at1102. No abstract available. Erratum In: Am J Respir Crit Care Med. 2016 May 15;193(10):1185.</citation>
    <PMID>12091180</PMID>
  </reference>
  <verification_date>June 2015</verification_date>
  <study_first_submitted>November 21, 2012</study_first_submitted>
  <study_first_submitted_qc>November 21, 2012</study_first_submitted_qc>
  <study_first_posted type="Estimate">November 27, 2012</study_first_posted>
  <last_update_submitted>June 24, 2015</last_update_submitted>
  <last_update_submitted_qc>June 24, 2015</last_update_submitted_qc>
  <last_update_posted type="Estimate">June 25, 2015</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <keyword>Assessment</keyword>
  <keyword>Rehabilitation</keyword>
  <keyword>Walking Constant Test</keyword>
  <keyword>Walking Graded test</keyword>
  <keyword>Six minute Walking test</keyword>
  <keyword>Walking Distance</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Peripheral Arterial Disease</mesh_term>
    <mesh_term>Peripheral Vascular Diseases</mesh_term>
    <mesh_term>Intermittent Claudication</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT01734603
org study id: DCIC 12
nct id: NCT01734603
lead sponsor: 
has dmc: Yes
Rehabilitation is the first intention treatment of peripheral arterial disease (PAD) with
      claudication. Initially proposed in the sixty's, rehabilitation programs dedicated to
      patients with PAD have recently been proved effective and defined in many guidelines.
      Supervised walking training on treadmill is recommended. Usually patients walk up to a mild
      or moderate pain (evaluated at 3 or 4 on the claudication pain scale; maximum pain =5), then
      stop until pain completely subsides and walk again .

      The Artex study assesses the efficacy of a fractionated mode of training avoiding pain by
      alternating short sequences of intensive training and active recovery (without rest).
Fractionated mode of training with active recovery has been proved effective in sport
      training as well as in Cardiac rehabilitation. We hypothesized it might be also interesting
      in the rehabilitation of patients with a peripheral arterial disease. The active recovery
      period might magnified the beneficial effect of a short intensive training.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: None (Open Label)
measure: Intensive Rehabilitation in Peripheral Arterial Disease with Claudication: effects of a treadmill training with active recovery
time frame: Between day 0 and day 28
description: Change in walking distance between day 0 and day 28, measured on a graded treadmill test
measure: Determine vascular and respiratory parameters which participate to improve the walking abilities after rehabilitation.
time frame: Between day 0 and day 28
description: Change in walking distance between day 0 and day 28, measured with the 6 MWT and the Strandness test.
Measure of ABI(Ankle-to- Brachial systolic blood pressure Index) and recovery time
Measure of the transcutaneous oxygen pression
Measure of the maximal cardiac frequency
Measure of peak oxygen consumption and lactatemy
measure: Determine vascular and respiratory parameters which participate to improve the walking abilities after rehabilitation.
time frame: Between day 0 and day 28
description: Measure of ABI(Ankle-to- Brachial systolic blood pressure Index) and recovery time
Measure of the transcutaneous oxygen pression
Measure of the maximal cardiac frequency
Measure of peak oxygen consumption and lactatemy
measure: One year follow-up
time frame: one year
description: All patients included are invited to be assessed at a one year. Interview, Clinical Examination, and Assessemnts are performed in day hospital (half a day).
Criteria are:
Patients 'satisfaction about protocole using an ad hoc ordinal scale Medical and duplex scan examinations Vascular risk factors and comorbidities Occurence of any medical event during the year Changes in WIQ and HADS changes in walking distance at the Graduated Treadmill Test.
measure: Reproducibility test of the walking graduated treadmill
time frame: Day 0 et day 1
description: The fifteen last patients are invited to perform the consecutive graduated treadmill test on day 0 et day 1. Reproducibility of the walking distance assess by this novel test is quantified.
measure: Handicap and Depression measures
time frame: Between day 0 and day 28
description: Walking Impairment Questionary WIQ
Hospital Anxiety and Depression Scale HADS
arm group label: conventional rehabilitation program
arm group type: Active Comparator
description: conventional rehabilitation program 20 patients are expected in this arm. Patients perform walking treadmill exercises with complete rest.
arm group label: experimental rehabilitation program
arm group type: Experimental
description: experimental rehabilitation program 20 patients are expected in this arm. Patients perform walking treadmill exercises with active recovery (no stop walking).
intervention type: Procedure
intervention name: experimental rehabilitation program
description: Duration training = 40 min : 5 cycles of 6 min each Week 1 speed of the walking exercise fixed at 70% of the max walking test's speed done on the initial walking test speed of the walking recovery fixed at 40% Walking slope : 0% Increase of the speed = 0.1 km/h after each training without pain.
Week 2 Walking speed = average of the walking speeds done on week 1 Walking slope = 1% Recovery slope = 0% Increase of the slope = 0.5% after each training without pain.
Week 3 Walking speed = 70% of the maximal walking test's speed Recovery speed = 40 % of the maximal walking test's speed Slope = average of the slopes done on week 2 Increase of the speed = 0.1 km/h .
Week 4 Speeds = average of the walking speeds done on week 3 Walking slope = 1% Recovery slope = 0% Increase of the slope is 0.5% .
arm group label: experimental rehabilitation program
intervention type: Procedure
intervention name: conventional rehabilitation program
description: Duration of the training 40 minutes (time excluding rest and warm up)
Initial intensity = 3.2 km per hour and slope at 0% Walking until pain 3/5, then stop until pain completely subsides.Resume of walking as soon as possible.
Increase :
Week 1: if the walking is possible during 8 minutes, increase of the slope of 0.5% in each training until 10% Week 2 :if the walking is possible during 8 minutes, increase of the speed 0.2 mile per hour until 3 mph Week 3 :if the walking is possible during 8 minutes, increase of the slope 2% at each training until 15% Week 4 : if the walking is possible during 8 minutes, increase the speed 0.2mph at each training as long as it is possible.
arm group label: conventional rehabilitation program
criteria: 
gender: All
minimum age: 18 Years
maximum age: 80 Years
healthy volunteers: No
last name: Béatrice VILLEMUR, MD
role: Principal Investigator
affiliation: Unité de rééducation vasculaire - Clinique médecine physique de rééducation - CHU Grenoble - Hôpital Sud
last name: Dominic Perennou, MD, PhD
role: Study Chair
affiliation: Rehabilitation Department, Universitary Hospital Grenoble
facility: 
country: France
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responsible party type: Sponsor
mesh term: Peripheral Arterial Disease
mesh term: Peripheral Vascular Diseases
mesh term: Intermittent Claudication