<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT01703377</url>
  </required_header>
  <id_info>
    <org_study_id>201203044RIC</org_study_id>
    <nct_id>NCT01703377</nct_id>
  </id_info>
  <brief_title>Effect of Constraining Joint Motions on Postural Control</brief_title>
  <official_title>Effect of Constraining Joint Motions on Postural Control</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>National Taiwan University Hospital</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>National Taiwan University Hospital</source>
  <oversight_info>
    <has_dmc>Yes</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      A major advantage of understanding a neural control scheme is able to simultaneously perform&#xD;
      multiple tasks based on the Uncontrolled Manifold (UCM) hypothesis by taking advantage of&#xD;
      motor redundancy. The present study aims to investigate this hypothesis further by examining&#xD;
      the effect of artificially eliminating knee and lumbar-thoracic joint motions on postural&#xD;
      control when the arms performing targeting task simultaneously in standing. Subjects (Younger&#xD;
      group: 20~35 years old; Elder group: 60~85 years old) will execute a targeting task with and&#xD;
      without an additional ball-balancing task in standing with free joint motions and with&#xD;
      restricted joint motions. The investigators expect to recruit 50 subjects for each group.&#xD;
      Analyses of joint configuration variance on the stability of the center of mass (COM)&#xD;
      position and the hand path will be performed using the UCM method of variance analysis. This&#xD;
      method partitions joint configuration variance into one component consistent with the use of&#xD;
      motor abundance and a component that leads to COM position or hand path variability.&#xD;
      Furthermore, the differences between the younger group and the elder group will be evaluated.&#xD;
    </textblock>
  </brief_summary>
  <overall_status>Unknown status</overall_status>
  <last_known_status>Recruiting</last_known_status>
  <start_date>April 2012</start_date>
  <completion_date type="Anticipated">December 2016</completion_date>
  <primary_completion_date type="Anticipated">December 2016</primary_completion_date>
  <study_type>Observational</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <observational_model>Case-Crossover</observational_model>
    <time_perspective>Cross-Sectional</time_perspective>
  </study_design_info>
  <enrollment type="Anticipated">30</enrollment>
  <condition>Healthy Adults</condition>
  <eligibility>
    <study_pop>
      <textblock>
        Healthy adults from 18-65 years old&#xD;
      </textblock>
    </study_pop>
    <sampling_method>Probability Sample</sampling_method>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
        Participants are healthy with no self-reported neurological deficits, musculoskeletal&#xD;
        conditions or motion sickness that affected their ability to maintain stable upright&#xD;
        posture.&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
        Participants are healthy with self-reported neurological deficits, musculoskeletal&#xD;
        conditions or motion sickness that affected their ability to maintain stable upright&#xD;
        posture.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>18 Years</minimum_age>
    <maximum_age>65 Years</maximum_age>
    <healthy_volunteers>Accepts Healthy Volunteers</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Wei-Li Hsu, PhD</last_name>
    <role>Principal Investigator</role>
    <affiliation>National Taiwan University</affiliation>
  </overall_official>
  <overall_contact>
    <last_name>Wei-Li Hsu, PhD</last_name>
    <phone>886-3366-8127</phone>
    <email>wlhsu@ntu.edu.tw</email>
  </overall_contact>
  <location>
    <facility>
      <name>School &amp; Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University</name>
      <address>
        <city>Taipei City</city>
        <zip>100</zip>
        <country>Taiwan</country>
      </address>
    </facility>
    <status>Recruiting</status>
    <contact>
      <last_name>Wei-Li Hsu, PhD</last_name>
      <email>wlhsu@ntu.edu.tw</email>
    </contact>
    <investigator>
      <last_name>Wei-Li Hsu, PhD</last_name>
      <role>Principal Investigator</role>
    </investigator>
  </location>
  <location_countries>
    <country>Taiwan</country>
  </location_countries>
  <verification_date>July 2015</verification_date>
  <study_first_submitted>October 5, 2012</study_first_submitted>
  <study_first_submitted_qc>October 9, 2012</study_first_submitted_qc>
  <study_first_posted type="Estimate">October 10, 2012</study_first_posted>
  <last_update_submitted>July 7, 2015</last_update_submitted>
  <last_update_submitted_qc>July 7, 2015</last_update_submitted_qc>
  <last_update_posted type="Estimate">July 8, 2015</last_update_posted>
  <responsible_party>
    <responsible_party_type>Sponsor</responsible_party_type>
  </responsible_party>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT01703377
org study id: 201203044RIC
nct id: NCT01703377
lead sponsor: 
has dmc: Yes
A major advantage of understanding a neural control scheme is able to simultaneously perform
      multiple tasks based on the Uncontrolled Manifold (UCM) hypothesis by taking advantage of
      motor redundancy. The present study aims to investigate this hypothesis further by examining
      the effect of artificially eliminating knee and lumbar-thoracic joint motions on postural
      control when the arms performing targeting task simultaneously in standing. Subjects (Younger
      group: 20~35 years old; Elder group: 60~85 years old) will execute a targeting task with and
      without an additional ball-balancing task in standing with free joint motions and with
      restricted joint motions. The investigators expect to recruit 50 subjects for each group.
      Analyses of joint configuration variance on the stability of the center of mass (COM)
      position and the hand path will be performed using the UCM method of variance analysis. This
      method partitions joint configuration variance into one component consistent with the use of
      motor abundance and a component that leads to COM position or hand path variability.
      Furthermore, the differences between the younger group and the elder group will be evaluated.
observational model: Case-Crossover
time perspective: Cross-Sectional
study pop: 
sampling method: Probability Sample
criteria: 
gender: All
minimum age: 18 Years
maximum age: 65 Years
healthy volunteers: Accepts Healthy Volunteers
last name: Wei-Li Hsu, PhD
role: Principal Investigator
affiliation: National Taiwan University
last name: Wei-Li Hsu, PhD
phone: 886-3366-8127
email: wlhsu@ntu.edu.tw
facility: 
status: Recruiting
contact: 
investigator: 
country: Taiwan
responsible party type: Sponsor