<clinical_study>
  <!-- This xml conforms to an XML Schema at:
    https://clinicaltrials.gov/ct2/html/images/info/public.xsd -->
  <required_header>
    <download_date>ClinicalTrials.gov processed this data on September 20, 2023</download_date>
    <link_text>Link to the current ClinicalTrials.gov record.</link_text>
    <url>https://clinicaltrials.gov/ct2/show/NCT01714791</url>
  </required_header>
  <id_info>
    <org_study_id>09.07/cardio09.01</org_study_id>
    <nct_id>NCT01714791</nct_id>
  </id_info>
  <brief_title>Effects of Osteopathic Treatment on Pulmonary Function After Coronary Artery Bypass Graft Surgery</brief_title>
  <acronym>OSTinCARE</acronym>
  <official_title>Effect of Osteopathy on Pulmonary Function in Patients After Coronary Artery Bypass Graft Surgery: a Randomized Controlled Trial</official_title>
  <sponsors>
    <lead_sponsor>
      <agency>Hartcentrum Hasselt</agency>
      <agency_class>Other</agency_class>
    </lead_sponsor>
  </sponsors>
  <source>Hartcentrum Hasselt</source>
  <oversight_info>
    <has_dmc>No</has_dmc>
  </oversight_info>
  <brief_summary>
    <textblock>
      The purpose of this study is to determine the short and long term effects of osteopathic&#xD;
      treatment on pulmonary function, pain and quality of life in patients after coronary artery&#xD;
      bypass graft (CABG) surgery. The study is a randomized controlled trial.&#xD;
    </textblock>
  </brief_summary>
  <detailed_description>
    <textblock>
      Coronary artery bypass graft (CABG) surgery is performed worldwide. Several studies have&#xD;
      found that there is a decrease in pulmonary function, loss of thoracic mobility and a high&#xD;
      prevalence of chronic poststernotomy pain (CPSP) after CABG. So far there is no effective&#xD;
      treatment for these conditions. The OstinCare study aims to investigate whether osteopathic&#xD;
      treatment has an added value in the treatment of these patients.&#xD;
    </textblock>
  </detailed_description>
  <overall_status>Terminated</overall_status>
  <why_stopped>
    Lack of new inclusions due to a significant change in surgery technique. An endoscopic&#xD;
    a-traumatic coronary artery bypass (endo-ACAB) approach is now used.&#xD;
  </why_stopped>
  <start_date>January 2010</start_date>
  <completion_date type="Actual">December 2017</completion_date>
  <primary_completion_date type="Actual">December 2017</primary_completion_date>
  <phase>N/A</phase>
  <study_type>Interventional</study_type>
  <has_expanded_access>No</has_expanded_access>
  <study_design_info>
    <allocation>Randomized</allocation>
    <intervention_model>Parallel Assignment</intervention_model>
    <primary_purpose>Treatment</primary_purpose>
    <masking>Single (Outcomes Assessor)</masking>
  </study_design_info>
  <primary_outcome>
    <measure>Change from baseline in slow vital capacity (SVC) at 12 weeks.</measure>
    <time_frame>preoperative (baseline) and 12 weeks postoperative</time_frame>
    <description>A Slow Vital Capacity (SVC) test will be performed at each time point.</description>
  </primary_outcome>
  <secondary_outcome>
    <measure>Change from baseline in slow vital capacity (SVC) at 52 weeks.</measure>
    <time_frame>preoperative (baseline) and 52 weeks postoperative</time_frame>
    <description>A SVC test will be performed at each time point.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change from baseline in McNew quality of life questionnaire at 12 weeks.</measure>
    <time_frame>3 weeks postoperative (baseline) and 12 weeks postoperative</time_frame>
    <description>McNew questionnaire will be done at 3 and 12 weeks after surgery.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change from baseline in McNew quality of life questionnaire at 52 weeks.</measure>
    <time_frame>3 weeks postoperative (baseline) and 52 weeks postoperative</time_frame>
    <description>McNew questionnaire will be done at 3, 12 and 52 weeks after surgery.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in pain from baseline on Visual Analogue Scale (VAS) at 12 weeks postoperative.</measure>
    <time_frame>3 weeks postoperative (baseline) and 12 weeks postoperative</time_frame>
    <description>Pain will be evaluated at 3 and 12 weeks after surgery.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in pain from baseline on VAS at 52 weeks postoperative.</measure>
    <time_frame>3 weeks postoperative (baseline) and 52 weeks postoperative</time_frame>
    <description>Pain will be evaluated at 3, 12 and 52 weeks after surgery.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in thoracic stiffness from baseline on VAS at 12 weeks postoperative.</measure>
    <time_frame>3 weeks postoperative (baseline) and 12 weeks postoperative</time_frame>
    <description>Thoracic stiffness will be evaluated at 3, 12 weeks after surgery.</description>
  </secondary_outcome>
  <secondary_outcome>
    <measure>Change in thoracic stiffness from baseline on VAS at 52 weeks postoperative.</measure>
    <time_frame>3 weeks postoperative (baseline) and 52 weeks postoperative</time_frame>
    <description>Thoracic stiffness will be evaluated at 3, 12 and 52 weeks after surgery.</description>
  </secondary_outcome>
  <other_outcome>
    <measure>Change from baseline in maximal aerobic capacity (VO2max) at 12 weeks postoperative</measure>
    <time_frame>3 weeks postoperative (baseline) and 12 weeks postoperative</time_frame>
    <description>All patients will perform a maximal cardiopulmonary exercise test on a cycle ergometer. The test will be performed at the cardiac rehabilitation centre by a trained operator and under supervision of a cardiologist.</description>
  </other_outcome>
  <other_outcome>
    <measure>Changes in thoracic mobility at 4, 12 and 52 weeks postoperative.</measure>
    <time_frame>4, 12 and 52 weeks postoperative</time_frame>
    <description>Osteopathic clinical examination of the thorax.</description>
  </other_outcome>
  <number_of_arms>2</number_of_arms>
  <enrollment type="Actual">112</enrollment>
  <condition>Mechanical Complication of Coronary Artery Bypass Graft</condition>
  <condition>Respiratory Depression</condition>
  <condition>Pain</condition>
  <condition>Quality of Life</condition>
  <arm_group>
    <arm_group_label>Usual care</arm_group_label>
    <arm_group_type>Active Comparator</arm_group_type>
    <description>Patients following the outpatient cardiac rehabilitation program.</description>
  </arm_group>
  <arm_group>
    <arm_group_label>Usual care and Osteopathic treatment</arm_group_label>
    <arm_group_type>Experimental</arm_group_type>
    <description>Patients following the outpatient cardiac rehabilitation program and receiving osteopathic treatment.</description>
  </arm_group>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Usual care</intervention_name>
    <description>Patients exercise at a heart rate corresponding to 65% of baseline Vo2peak. Each exercise training session takes 40-60 minutes. Exercise time is apportioned as follows: 42% on the treadmill, 33% on the circle ergometer and 25% on the arm cranking device. All patients exercise under close supervision 3 days per week for a total duration of 12 weeks.</description>
    <arm_group_label>Usual care</arm_group_label>
    <arm_group_label>Usual care and Osteopathic treatment</arm_group_label>
    <other_name>Outpatient cardiac rehabilitation</other_name>
  </intervention>
  <intervention>
    <intervention_type>Other</intervention_type>
    <intervention_name>Osteopathic treatment</intervention_name>
    <description>Patients receive 4 osteopathic treatments (OT). OT is performed in week 4, 5, 8 and 12 postoperative. Depending on what is found in the patient, treatments consist mostly of one or more of the following approaches:&#xD;
Structural High Velocity Low Amplitude-techniques.&#xD;
Muscle Energy Techniques.&#xD;
General osteopathic mobilisations.&#xD;
Functional techniques (Sutherland-, Jones-techniques,…) including inhibition techniques.&#xD;
Fascia techniques.&#xD;
Soft tissue- and connective tissue techniques.&#xD;
Neurovisceral and neurolymphatic reflex techniques.&#xD;
Fluidal techniques (lymphatic manipulative techniques,...).&#xD;
Visceral manipulations.&#xD;
Neurocranial and viscerocranial techniques.</description>
    <arm_group_label>Usual care and Osteopathic treatment</arm_group_label>
  </intervention>
  <eligibility>
    <criteria>
      <textblock>
        Inclusion Criteria:&#xD;
&#xD;
          -  Planned Coronary Artery Bypass Graft (CABG) surgery at the Jessa Hospital Hasselt&#xD;
&#xD;
          -  Planned Endoscopic Atraumatic Coronary Artery Bypass (endo ACAB) surgery at the Jessa&#xD;
             Hospital&#xD;
&#xD;
          -  Planned Minimal Invasive Aortic Valve Replacement (mini AVR) surgery at the Jessa&#xD;
             Hospital&#xD;
&#xD;
        Exclusion Criteria:&#xD;
&#xD;
          -  Thoracic surgery in the past&#xD;
&#xD;
          -  Redo CABG&#xD;
&#xD;
          -  Complications after CABG, requiring long-term (more than 6 days) admission to&#xD;
             intensive care&#xD;
&#xD;
          -  Pathologies of the lungs&#xD;
&#xD;
          -  Pathologies of the heart, other than the coronary artery disease&#xD;
&#xD;
          -  Surgery in the sub diaphragmatic region: epigastric region, left and right&#xD;
             hypochondriac region.&#xD;
      </textblock>
    </criteria>
    <gender>All</gender>
    <minimum_age>N/A</minimum_age>
    <maximum_age>N/A</maximum_age>
    <healthy_volunteers>No</healthy_volunteers>
  </eligibility>
  <overall_official>
    <last_name>Gert Roncada, DO, MSc</last_name>
    <role>Principal Investigator</role>
    <affiliation>Heart Centre Hasselt</affiliation>
  </overall_official>
  <location>
    <facility>
      <name>Cardiac rehabilitation centre at the Jessa Hospital Hasselt</name>
      <address>
        <city>Hasselt</city>
        <state>Limburg</state>
        <zip>3500</zip>
        <country>Belgium</country>
      </address>
    </facility>
  </location>
  <location_countries>
    <country>Belgium</country>
  </location_countries>
  <reference>
    <citation>Kristjansdottir A, Ragnarsdottir M, Hannesson P, Beck HJ, Torfason B. Chest wall motion and pulmonary function are more diminished following cardiac surgery when the internal mammary artery retractor is used. Scand Cardiovasc J. 2004 Dec;38(6):369-74. doi: 10.1080/14017430410016396.</citation>
    <PMID>15804805</PMID>
  </reference>
  <reference>
    <citation>Kristjansdottir A, Ragnarsdottir M, Hannesson P, Beck HJ, Torfason B. Respiratory movements are altered three months and one year following cardiac surgery. Scand Cardiovasc J. 2004 May;38(2):98-103. doi: 10.1080/14017430410028492.</citation>
    <PMID>15204235</PMID>
  </reference>
  <reference>
    <citation>Ragnarsdottir M, Kristinsdottir EK. Breathing movements and breathing patterns among healthy men and women 20-69 years of age. Reference values. Respiration. 2006;73(1):48-54. doi: 10.1159/000087456. Epub 2005 Aug 11.</citation>
    <PMID>16106113</PMID>
  </reference>
  <reference>
    <citation>Ragnarsdottir M, KristjAnsdottir A, Ingvarsdottir I, Hannesson P, Torfason B, Cahalin L. Short-term changes in pulmonary function and respiratory movements after cardiac surgery via median sternotomy. Scand Cardiovasc J. 2004 Mar;38(1):46-52. doi: 10.1080/14017430310016658.</citation>
    <PMID>15204247</PMID>
  </reference>
  <reference>
    <citation>Bruce J, Drury N, Poobalan AS, Jeffrey RR, Smith WC, Chambers WA. The prevalence of chronic chest and leg pain following cardiac surgery: a historical cohort study. Pain. 2003 Jul;104(1-2):265-73. doi: 10.1016/s0304-3959(03)00017-4. Erratum In: Pain. 2004 Dec;112(3):413.</citation>
    <PMID>12855337</PMID>
  </reference>
  <reference>
    <citation>Kalso E, Mennander S, Tasmuth T, Nilsson E. Chronic post-sternotomy pain. Acta Anaesthesiol Scand. 2001 Sep;45(8):935-9. doi: 10.1034/j.1399-6576.2001.450803.x.</citation>
    <PMID>11576042</PMID>
  </reference>
  <reference>
    <citation>Locke TJ, Griffiths TL, Mould H, Gibson GJ. Rib cage mechanics after median sternotomy. Thorax. 1990 Jun;45(6):465-8. doi: 10.1136/thx.45.6.465.</citation>
    <PMID>2392792</PMID>
  </reference>
  <reference>
    <citation>Mazzeffi M, Khelemsky Y. Poststernotomy pain: a clinical review. J Cardiothorac Vasc Anesth. 2011 Dec;25(6):1163-78. doi: 10.1053/j.jvca.2011.08.001. Epub 2011 Sep 29. No abstract available.</citation>
    <PMID>21955825</PMID>
  </reference>
  <reference>
    <citation>Meyerson J, Thelin S, Gordh T, Karlsten R. The incidence of chronic post-sternotomy pain after cardiac surgery--a prospective study. Acta Anaesthesiol Scand. 2001 Sep;45(8):940-4. doi: 10.1034/j.1399-6576.2001.450804.x.</citation>
    <PMID>11576043</PMID>
  </reference>
  <reference>
    <citation>van Gulik L, Janssen LI, Ahlers SJ, Bruins P, Driessen AH, van Boven WJ, van Dongen EP, Knibbe CA. Risk factors for chronic thoracic pain after cardiac surgery via sternotomy. Eur J Cardiothorac Surg. 2011 Dec;40(6):1309-13. doi: 10.1016/j.ejcts.2011.03.039. Epub 2011 May 10.</citation>
    <PMID>21561786</PMID>
  </reference>
  <reference>
    <citation>van Leersum NJ, van Leersum RL, Verwey HF, Klautz RJ. Pain symptoms accompanying chronic poststernotomy pain: a pilot study. Pain Med. 2010 Nov;11(11):1628-34. doi: 10.1111/j.1526-4637.2010.00975.x.</citation>
    <PMID>21044253</PMID>
  </reference>
  <reference>
    <citation>Westerdahl E, Lindmark B, Bryngelsson I, Tenling A. Pulmonary function 4 months after coronary artery bypass graft surgery. Respir Med. 2003 Apr;97(4):317-22. doi: 10.1053/rmed.2002.1424.</citation>
    <PMID>12693792</PMID>
  </reference>
  <reference>
    <citation>Hansen D, Dendale P, Berger J, Meeusen R. Rehabilitation in cardiac patients:what do we know about training modalities? Sports Med. 2005;35(12):1063-84. doi: 10.2165/00007256-200535120-00005.</citation>
    <PMID>16336009</PMID>
  </reference>
  <reference>
    <citation>Alston RP, Pechon P. Dysaesthesia associated with sternotomy for heart surgery. Br J Anaesth. 2005 Aug;95(2):153-8. doi: 10.1093/bja/aei152. Epub 2005 May 13.</citation>
    <PMID>15894562</PMID>
  </reference>
  <reference>
    <citation>Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005 Aug;26(2):319-38. doi: 10.1183/09031936.05.00034805. No abstract available.</citation>
    <PMID>16055882</PMID>
  </reference>
  <verification_date>March 2018</verification_date>
  <study_first_submitted>October 18, 2012</study_first_submitted>
  <study_first_submitted_qc>October 25, 2012</study_first_submitted_qc>
  <study_first_posted type="Estimate">October 26, 2012</study_first_posted>
  <last_update_submitted>March 1, 2018</last_update_submitted>
  <last_update_submitted_qc>March 1, 2018</last_update_submitted_qc>
  <last_update_posted type="Actual">March 5, 2018</last_update_posted>
  <responsible_party>
    <responsible_party_type>Principal Investigator</responsible_party_type>
    <investigator_affiliation>Hartcentrum Hasselt</investigator_affiliation>
    <investigator_full_name>Roncada Gert</investigator_full_name>
    <investigator_title>Principal Investigator</investigator_title>
  </responsible_party>
  <keyword>Coronary Artery Bypass Graft</keyword>
  <keyword>Osteopathic Medicine</keyword>
  <keyword>Vital Capacity</keyword>
  <keyword>Quality of Life</keyword>
  <keyword>Cardiac rehabilitation</keyword>
  <condition_browse>
    <!-- CAUTION:  The following MeSH terms are assigned with an imperfect algorithm            -->
    <mesh_term>Respiratory Insufficiency</mesh_term>
  </condition_browse>
  <!-- Results have not yet been posted for this study                                          -->
</clinical_study>


download date: ClinicalTrials.gov processed this data on September 20, 2023
link text: Link to the current ClinicalTrials.gov record.
url: https://clinicaltrials.gov/ct2/show/NCT01714791
org study id: 09.07/cardio09.01
nct id: NCT01714791
lead sponsor: 
has dmc: No
The purpose of this study is to determine the short and long term effects of osteopathic
      treatment on pulmonary function, pain and quality of life in patients after coronary artery
      bypass graft (CABG) surgery. The study is a randomized controlled trial.
Coronary artery bypass graft (CABG) surgery is performed worldwide. Several studies have
      found that there is a decrease in pulmonary function, loss of thoracic mobility and a high
      prevalence of chronic poststernotomy pain (CPSP) after CABG. So far there is no effective
      treatment for these conditions. The OstinCare study aims to investigate whether osteopathic
      treatment has an added value in the treatment of these patients.
allocation: Randomized
intervention model: Parallel Assignment
primary purpose: Treatment
masking: Single (Outcomes Assessor)
measure: Change from baseline in slow vital capacity (SVC) at 12 weeks.
time frame: preoperative (baseline) and 12 weeks postoperative
description: A Slow Vital Capacity (SVC) test will be performed at each time point.
measure: Change from baseline in slow vital capacity (SVC) at 52 weeks.
time frame: preoperative (baseline) and 52 weeks postoperative
description: A SVC test will be performed at each time point.
measure: Change from baseline in McNew quality of life questionnaire at 12 weeks.
time frame: 3 weeks postoperative (baseline) and 12 weeks postoperative
description: McNew questionnaire will be done at 3 and 12 weeks after surgery.
measure: Change from baseline in McNew quality of life questionnaire at 52 weeks.
time frame: 3 weeks postoperative (baseline) and 52 weeks postoperative
description: McNew questionnaire will be done at 3, 12 and 52 weeks after surgery.
measure: Change in pain from baseline on Visual Analogue Scale (VAS) at 12 weeks postoperative.
time frame: 3 weeks postoperative (baseline) and 12 weeks postoperative
description: Pain will be evaluated at 3 and 12 weeks after surgery.
measure: Change in pain from baseline on VAS at 52 weeks postoperative.
time frame: 3 weeks postoperative (baseline) and 52 weeks postoperative
description: Pain will be evaluated at 3, 12 and 52 weeks after surgery.
measure: Change in thoracic stiffness from baseline on VAS at 12 weeks postoperative.
time frame: 3 weeks postoperative (baseline) and 12 weeks postoperative
description: Thoracic stiffness will be evaluated at 3, 12 weeks after surgery.
measure: Change in thoracic stiffness from baseline on VAS at 52 weeks postoperative.
time frame: 3 weeks postoperative (baseline) and 52 weeks postoperative
description: Thoracic stiffness will be evaluated at 3, 12 and 52 weeks after surgery.
measure: Change from baseline in maximal aerobic capacity (VO2max) at 12 weeks postoperative
time frame: 3 weeks postoperative (baseline) and 12 weeks postoperative
description: All patients will perform a maximal cardiopulmonary exercise test on a cycle ergometer. The test will be performed at the cardiac rehabilitation centre by a trained operator and under supervision of a cardiologist.
measure: Changes in thoracic mobility at 4, 12 and 52 weeks postoperative.
time frame: 4, 12 and 52 weeks postoperative
description: Osteopathic clinical examination of the thorax.
arm group label: Usual care
arm group type: Active Comparator
description: Patients following the outpatient cardiac rehabilitation program.
arm group label: Usual care and Osteopathic treatment
arm group type: Experimental
description: Patients following the outpatient cardiac rehabilitation program and receiving osteopathic treatment.
intervention type: Other
intervention name: Usual care
description: Patients exercise at a heart rate corresponding to 65% of baseline Vo2peak. Each exercise training session takes 40-60 minutes. Exercise time is apportioned as follows: 42% on the treadmill, 33% on the circle ergometer and 25% on the arm cranking device. All patients exercise under close supervision 3 days per week for a total duration of 12 weeks.
arm group label: Usual care
arm group label: Usual care and Osteopathic treatment
other name: Outpatient cardiac rehabilitation
intervention type: Other
intervention name: Osteopathic treatment
description: Patients receive 4 osteopathic treatments (OT). OT is performed in week 4, 5, 8 and 12 postoperative. Depending on what is found in the patient, treatments consist mostly of one or more of the following approaches:
Structural High Velocity Low Amplitude-techniques.
Muscle Energy Techniques.
General osteopathic mobilisations.
Functional techniques (Sutherland-, Jones-techniques,…) including inhibition techniques.
Fascia techniques.
Soft tissue- and connective tissue techniques.
Neurovisceral and neurolymphatic reflex techniques.
Fluidal techniques (lymphatic manipulative techniques,...).
Visceral manipulations.
Neurocranial and viscerocranial techniques.
arm group label: Usual care and Osteopathic treatment
criteria: 
gender: All
minimum age: N/A
maximum age: N/A
healthy volunteers: No
last name: Gert Roncada, DO, MSc
role: Principal Investigator
affiliation: Heart Centre Hasselt
facility: 
country: Belgium
citation: Kristjansdottir A, Ragnarsdottir M, Hannesson P, Beck HJ, Torfason B. Chest wall motion and pulmonary function are more diminished following cardiac surgery when the internal mammary artery retractor is used. Scand Cardiovasc J. 2004 Dec;38(6):369-74. doi: 10.1080/14017430410016396.
PMID: 15804805
citation: Kristjansdottir A, Ragnarsdottir M, Hannesson P, Beck HJ, Torfason B. Respiratory movements are altered three months and one year following cardiac surgery. Scand Cardiovasc J. 2004 May;38(2):98-103. doi: 10.1080/14017430410028492.
PMID: 15204235
citation: Ragnarsdottir M, Kristinsdottir EK. Breathing movements and breathing patterns among healthy men and women 20-69 years of age. Reference values. Respiration. 2006;73(1):48-54. doi: 10.1159/000087456. Epub 2005 Aug 11.
PMID: 16106113
citation: Ragnarsdottir M, KristjAnsdottir A, Ingvarsdottir I, Hannesson P, Torfason B, Cahalin L. Short-term changes in pulmonary function and respiratory movements after cardiac surgery via median sternotomy. Scand Cardiovasc J. 2004 Mar;38(1):46-52. doi: 10.1080/14017430310016658.
PMID: 15204247
citation: Bruce J, Drury N, Poobalan AS, Jeffrey RR, Smith WC, Chambers WA. The prevalence of chronic chest and leg pain following cardiac surgery: a historical cohort study. Pain. 2003 Jul;104(1-2):265-73. doi: 10.1016/s0304-3959(03)00017-4. Erratum In: Pain. 2004 Dec;112(3):413.
PMID: 12855337
citation: Kalso E, Mennander S, Tasmuth T, Nilsson E. Chronic post-sternotomy pain. Acta Anaesthesiol Scand. 2001 Sep;45(8):935-9. doi: 10.1034/j.1399-6576.2001.450803.x.
PMID: 11576042
citation: Locke TJ, Griffiths TL, Mould H, Gibson GJ. Rib cage mechanics after median sternotomy. Thorax. 1990 Jun;45(6):465-8. doi: 10.1136/thx.45.6.465.
PMID: 2392792
citation: Mazzeffi M, Khelemsky Y. Poststernotomy pain: a clinical review. J Cardiothorac Vasc Anesth. 2011 Dec;25(6):1163-78. doi: 10.1053/j.jvca.2011.08.001. Epub 2011 Sep 29. No abstract available.
PMID: 21955825
citation: Meyerson J, Thelin S, Gordh T, Karlsten R. The incidence of chronic post-sternotomy pain after cardiac surgery--a prospective study. Acta Anaesthesiol Scand. 2001 Sep;45(8):940-4. doi: 10.1034/j.1399-6576.2001.450804.x.
PMID: 11576043
citation: van Gulik L, Janssen LI, Ahlers SJ, Bruins P, Driessen AH, van Boven WJ, van Dongen EP, Knibbe CA. Risk factors for chronic thoracic pain after cardiac surgery via sternotomy. Eur J Cardiothorac Surg. 2011 Dec;40(6):1309-13. doi: 10.1016/j.ejcts.2011.03.039. Epub 2011 May 10.
PMID: 21561786
citation: van Leersum NJ, van Leersum RL, Verwey HF, Klautz RJ. Pain symptoms accompanying chronic poststernotomy pain: a pilot study. Pain Med. 2010 Nov;11(11):1628-34. doi: 10.1111/j.1526-4637.2010.00975.x.
PMID: 21044253
citation: Westerdahl E, Lindmark B, Bryngelsson I, Tenling A. Pulmonary function 4 months after coronary artery bypass graft surgery. Respir Med. 2003 Apr;97(4):317-22. doi: 10.1053/rmed.2002.1424.
PMID: 12693792
citation: Hansen D, Dendale P, Berger J, Meeusen R. Rehabilitation in cardiac patients:what do we know about training modalities? Sports Med. 2005;35(12):1063-84. doi: 10.2165/00007256-200535120-00005.
PMID: 16336009
citation: Alston RP, Pechon P. Dysaesthesia associated with sternotomy for heart surgery. Br J Anaesth. 2005 Aug;95(2):153-8. doi: 10.1093/bja/aei152. Epub 2005 May 13.
PMID: 15894562
citation: Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005 Aug;26(2):319-38. doi: 10.1183/09031936.05.00034805. No abstract available.
PMID: 16055882
responsible party type: Principal Investigator
investigator affiliation: Hartcentrum Hasselt
investigator full name: Roncada Gert
investigator title: Principal Investigator
mesh term: Respiratory Insufficiency