If Substance A is more soluble in water than Substance B, will Substance A be more easily absorbed by the body?

I am comparing the solubilities of artificial vs natural sweeteners for my Chemistry IB Internal Assessment. I must demonstrate personal engagement, so I am relating my topic to weight management in which I am saying that if a sweetener is more soluble in water, then it will be more easily absorbed by the body. Ergo, since the body's need for carbohydrates has been satiated, one will feel less need to eat sugar, thus aiding in weight loss. 


I'm not quite sure if the above is true, so I would be very open to any suggestions or corrections. Please indicate any reference material in your answers to my question. 


Thank you very much! 


