Would an effervescent tablet react with itself if ground into a nanopowder?

[Effervescent tablets](https://en.wikipedia.org/wiki/Effervescent_tablet) usually are a mixture of a weak acid, base, and binder. When dry there is no reaction. But when placed in water the acid-base neutralization releases CO2 rapidly.


If you ground a (dry) tablet into nanopowder, the acid and base grains would have enormous surface area. Would this cause them to react despite having no solvent?


