Toluenesulfonate vs. methylsulfonate

Are there any advantages/disadvantages of using toluenesulfonate instead of methylsulfonate as a leaving group in E2 and SN2 reactions? I know they are both excellent leaving groups but how do they compare to each other? Is there a green chemistry aspect to it? 


Thank you!




* From the point of atom efficiency, methylsulfonate is advantageous compared to the *p*-toluenesulfonate.
* On the reagent itself, the methanesulfonate is more polar than the *p*-TsOH; so the later dissolves better in less polar organic solvents than the former. Methanesulfonate even may be used to dissolve some metal salts.
* If used to generate a better leaving group, on workup, a methanesulfonate enters the aqueous phase easier than the tosylate.
* *p*-TsOH is a cheap, widely available solid (sometimes sold as hydrate) you may prepare by your own in large quantities; methanesulfonate however is a liquid, hence potentially easier to add continuously, and more expensive (even more so, per mL, the triflates).
* Methyl sulfonates are able to alkylate DNA, hence potentially carcinogen. For tosylates, *currently* there is not such evidence (but obviously the dust of this strong acid is considered harmful).


As a personal note, among other reasons I found consultation of journals like [Organic Process Research & Development](http://pubs.acs.org/journal/oprdfk) just under this aspect (including green chemistry) as useful in two ways: i) publications describing how running a particular reaction *within a chain* of others works well / better than an other -- especially on larger scales of application--, and ii) the sections in line of "Some Items of Interest to Process R&D Chemists and Engineers". 


**Addendum:** There are dedicated compilations to figure out scope and limitations of chemical reagents. To mention only two, [Fieser & Fieser](http://onlinelibrary.wiley.com/book/10.1002/9780471264194) and [EROS](http://onlinelibrary.wiley.com/book/10.1002/047084289X) edited by Leo Paquette (there is an e-EROS as electronic ressource, too) are multivolume references.


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In my experience mesylate forms more quickly using std conditions of MsCl/Et3N/DCM.


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