What are the specific disadvantages of using a bio-catalyst (called Lipolase) in the synthesis of the drug pregabalin?

I am studying the synthesis of a drug [pregabalin](http://en.wikipedia.org/wiki/Pregabalin), for which both chemical and bio-catalysts are used. Using a biocatalyst is way better than chemical route, as explained [here](https://www.dbu.de/media/130508051211a525.pdf). In fact, The invention of the bio-catalyst route got 2006 IchemE award in Green Chemistry and Engineering.


I am interested in knowing is this: are there any disadvantages of using bio-catalysis in this reaction? (Some general disadvantages can be seen [here](http://www.answers.com/Q/What_are_disadvantages_of_using_a_catalyst_on_and_industrial_reaction)) Suppose you are in a debate and you have to favor the chemical side, what would be your arguments?


