Can all NMR spectrometers perform special techniques such as COSY, NOESY, HETCOR,..? [closed]








**Closed**. This question needs [details or clarity](/help/closed-questions). It is not currently accepting answers.
 
 






---








**Want to improve this question?** Add details and clarify the problem by [editing this post](/posts/129376/edit).




Closed 3 years ago.








[Improve this question](/posts/129376/edit) 



Do you need special spectrometers for:


* probing nuclei other than hydrogen or carbon?
* performing 2D spectroscopy such as COSY, NOESY, HETCOR, HSQC,..


Or are these techniques usually available on standard NMR spectrometers?




It depends on *a lot* of things, software-wise


* some of these techniques are simply a software option
* you can implement pulse sequences yourself, if that´s possible with your control software
* you need to have the right software to transform and evaluate the data
* ... or write it yourself (not exactly rocket science if you know your way with Matlab/Octave etc.)


and also regarding your hardware


* you can have several probes for one spectrometer
	+ they can be single channel, or dual ("HX" usually), triple ... channel
	+ the "X" channel can be tuneable over a wide(r) range, or you are limited to e.g. carbon
* of course you need a transceiver with enough channels, which can be used at the wanted frequencies
* and a suitable preamp for every channel
* some techniques need more special hardware, like CPMAS, pulsed gradients, cryo etc.
* low field spectrometers on the market (afaik) have no user exchangable parts, so you are stuck with the hardware you bought


But to answer your immediate question: I guess with basically any living (as in "not undead") spectrometer, all those you named above should be possible, provided you can tune the X channel to the het nucleus you are after. They are the basic standards. 


If you want to know a lot more, [*200 and More NMR Experiments*](https://www.wiley.com/en-us/200+and+More+NMR+Experiments%3A+A+Practical+Course-p-9783527310678) by Berger and Braun is probably your book.


 10

There are multiple aspects to consider here.


* In terms of *the magnet*, the ones suitable to record a $300$ or $500\, \pu{MHz}$ $\ce{^1H}$ NMR spectrum may be well used to record 1D or 2D homo- and heteronuclear spectra as well.
* Other nuclei than $\ce{^1H}$ or $\ce{^{13}C}$ routinely are recorded in 1D with these standard spectrometers as well; for example $\ce{^{15}N}$, $\ce{^{19}F}$, $\ce{^{31}P}$ often relevant in samples equally relevant for biochemistry (heterocyclic chemistry, proteins); or inorganic chemistry (e.g., $\ce{^{117}Sn}$, $\ce{^{119}Sn}$, $\ce{^{195}Pt}$).
* Recording spectra with nuclei other than H and C however *often* is performed with dedicated probeheads. As an example, you are used that DEPT-135 / DEPT-Q / APT spectra are recorded to seemingly yield singlet signals only by proton broadband decoupling. A standard two-channel probehead however is not designed to equally decouple $\ce{^{19}F}$ beside $\ce{^{1}H}$, for example, and consequently your 1D $\ce{^{13}C}$ spectrum still show the couplings with $\ce{^{19}F}$: 


[![enter image description here](https://i.stack.imgur.com/yCE9h.jpg)](https://i.stack.imgur.com/yCE9h.jpg) 


([source](https://u-of-o-nmr-facility.blogspot.com/search/label/13C-19F%2020coupling))


An other example is recording NMR spectra for three types nuclei *at once* by *triple resonance* with three scales, as seen in biochemistry to elucidate protein structures. (An entry to this vaste topic might be Wuethrich's Nobel lecture 2002, [here](https://www.nobelprize.org/prizes/chemistry/2002/wuthrich/lecture/).)


[![enter image description here](https://i.stack.imgur.com/CMGD1.png)](https://i.stack.imgur.com/CMGD1.png)


([source](https://www.protein-nmr.org.uk/solution-nmr/assignment-theory/visualising-3d-spectra/))


Displaying only the mount of the heads still visible on the bottom of the NMR magnet, this would not be possible with a standard probehead:
[![enter image description here](https://i.stack.imgur.com/RBTlF.png)](https://i.stack.imgur.com/RBTlF.png)


([source](https://www.uwyo.edu/chemistry/instrumentation/nmr/nmr-probes.html))


but would recorded comfortably with a triple-resonance head like this
[![enter image description here](https://i.stack.imgur.com/N8yIP.png)](https://i.stack.imgur.com/N8yIP.png)


([source](https://www.ebay.com/itm/BRUKER-500MHz-5mm-NMR-Probe-with-Gradients-Nuclear-Magnetic-Resonance/232806178548?_trkparms=aid%3D1110001%26algo%3DSPLICE.SIM%26ao%3D2%26asc%3D20160323102634%26meid%3D04a617733030407bb0394876833349e6%26pid%3D100623%26rk%3D3%26rkt%3D6%26sd%3D183622269613%26itm%3D232806178548%26pmt%3D0%26noa%3D1%26pg%3D2047675&_trksid=p2047675.c100623.m-1))
* Recording NMR spectra requires adjustment of pulse sequences (e.g., delay times and phases). Typical parameters are literature known (e.g. [APT for $\ce{^{13}C}$](https://doi.org/10.1016/0022-2364(82)90105-6) in the [*Journal of Magnetic Resonance*](https://www.sciencedirect.com/journal/journal-of-magnetic-resonance)), so the software of the spectrometer may internally look up and adjust thes for the more frequently used ones experiments. Occasionally, you find blogs about these techniques, too (e.g., [University of Ottawa](https://u-of-o-nmr-facility.blogspot.com/), [PNA](https://www.process-nmr.com/blog/))


 7