Can I scrape off compounds from normal TLC like in prep TLC for MS analysis?

As far as I know, the limit of detection of mass spectrometry is very low compared to other analysis. In principle, so I think I can scrape off some compounds from normal TLC plate after development like in prep TLC, filter with appropriate solvent, and get the filtrate. But I have never seen this application. I think there are some reasons for which one can't carry out it, but can't occur to definite reason.


