Does isotretinoin affects contraception hormonal pills - Ethinylestradiolum, Drospirenonum

Does isotretinoin affects contraception hormonal pills - Ethinylestradiolum, Drospirenonum? Asking as a pharmacologist not a patient.




My professional knowledge of vitamin A derivatives is limited to preparative aspects and some photochemical properties. 


But it seems that the German [Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM)](http://www.bfarm.de/) provides some information in german and english.


I didn't know whether a link to the search would survive the session, so the link above is just to their website and you would need to search yourself in case you're interested.




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Note: I had a look at the *Fachinformationen* (RTF in German) among the documents "linked".


In this publication, it is very explicitly pointed out that Isotretinoin is a **TERATOGEN** and efficient contraception therefore is absolutely vital (in the truest sense of the word).


It is suggested that patients use **two independent** methods of contraception, of which one should be a "barrier method", e.g. the use of condoms.


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