Method to determine ibuprofen content in dosage forms [closed]








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Please suggest some methods for determining the ibuprofen content in tablets, capsules and liquid dosage forms.


Is there a method which this can be done using UV spectroscopy?




Common methods in quantitative analysis of ibuprofen are


* titration with sodium hydroxide in methanol,
* potentiometric titration,
* chromatography combined with mass spectrometry,
* IR spectroscopy[[1](http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-07932005000300004)], or
* UV spectroscopy (273 $\pu{nm}$[[1](http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-07932005000300004)]).


Some of these methods, e.g. UV or IR spectroscopy require extraction of the active ingredient.


Ref.: [[1](http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-07932005000300004)] S. R. Matkovic, G. M. Valle and L. E. Briand, Quantitative analysis of ibuprofen in pharmaceutical formulations through FTIR spectroscopy


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