A case of composite hemangioendothelioma of the tongue

Keywords: 

Composite hemangioendothelioma is a rare vascular neoplasm of intermediate malignant potential, characterized by complex admixtures of benign, intermediate, and malignant vascular components. Here we describe a case of composite hemangioendothelioma arising in the tongue. An 81-year-old man presented with a several-day history of a mass in the right edge of the tongue. On presentation, a painless, blue-violet, wellcircumscribed tumor mass measuring approximately 10 mm in diameter was found in the right edge of the tongue. Coloration of the mass faded on pressure. There was no swelling or tenderness of the lymph nodes. 
The mass was surgically excised, including the normal tissue. On histopathological examination, the tumor comprised retiform hemangioendothelioma, epithelioid hemangioendothelioma, and cavernous hemangioma. 
We diagnosed composite hemangioendothelioma based on the admixture of multiple vascular lesions. There has been no evidence of recurrence or metastasis as of 2 years postoperatively. 




  -Filho JS, Paiva ME, et al : Congenital composite hemangioendothelioma: case report and reappraisal of the hemangioendothelioma spectrum. J Cutan Pathol 29: 226-231, 2002. 4 ) Sapunar J, Roa JC, et al : Reversion of hypophosphatemia after the excision of a composite hemangioen-dothelioma in the great toe. Rev Med Chil 131: 909-914, 2003. 5 ) Biagioli M, Sbano P, et al : Composite cutaneous haemangioendothelioma: case report and review of the literature. Clin Exp Dermatol 30: 385-387, 2005. 6 ) Fukunaga M, Suzuki K, et al : Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome. Am J Surg Pathol 31: 1567-1572, 2007. 7 ) Fasolis M, Iaquinta C, et al : Composite hemangioendothelioma of the oral cavity: case report and review of the literature. Head Neck 30: 974-979, 2008. 8 ) Requena L, Luis Díaz J, et al : Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases. J Cutan Pathol 35: 225-230, 2008. 9 ) Tejera-Vaquerizo A, Herrera-Ceballos E, et al : Composite cutaneous hemangioendothelioma on the back. Am J Dermatopathol 30: 262-264, 2008. 10) Utaí S, Canöz O, et al : Composite cutaneous haemangioendothelioma treated with interferon. J Eur Acad Dermatol Venereol 22: 503-505, 2008. 11) Aydingöz IE, Demirkesen C, et al : Composite haemangioendothelioma with lymph-node metastasis: an unusual presentation at an uncommon site. YL, Chen WX, et al : Composite hemangioendothelioma on the neck. Kaohsiung J Med Sci 28: 564-565, 2012. 17) Yoda Y and Ohashi M : A case of composite hemangioendothelioma arising from the spleen. Jpn J Clin Oncol 42: 770, 2012. 18) Liau JY, Lee FY, et al : Composite hemangioendothelioma presenting as a scalp nodule with alopecia. J Am Acad Dermatol 69: 98-99, 2013. 19) McNab PM, Quigley BC, et al : Composite hemangioendothelioma and its classification as a low-grade malignancy. Am J Dermatopathol 35: 517-522, 2013. 20) Tateishi J, Saeki H, et al : Cutaneous composite hemangioendothelioma on the nose treated with electron beam. Int J Dermatol 52: 1618-1619, 2013. 21) Zhang J, Wu B, et al : Composite hemangioendothelioma arising from the kidney: case report with review of the literature. Int J Clin Exp Pathol 6: 1935-1941, 2013. 22) Dong A, Bai Y, et al : Bone scan, MRI, and FDG PET/ CT findings in composite hemangioendothelioma of 


23) ．顎口腔領域での治療は安全域を設けた腫

  
				舌に発生した複合型血管内皮腫の 1 例			
			表 1 顎口腔領域に発生した複合型血管内皮腫の報告例		
	No.	報告者	報告年	年齢	性別	部位	大きさ 直径	形態	治療内容	再発 / 転移
	1	Nayler ら 1 )	2000	70	男	舌	不明	不明	腫瘍切除術	あり / あり
	2	Fukunaga ら 6 )	2007	44	男	口底	13mm	腫瘤	腫瘍切除術	なし / なし
	3	Fasolis ら 7 )	2008	38	男	頰粘膜	25mm	潰瘍	腫瘍切除術	なし / なし
	4	柳生ら 15)	2011	47	男	舌	8 mm	腫瘤	腫瘍切除術	なし / なし
	5	Leen ら 25)	2015	43	男	顎下部	25mm	腫瘤	頸部郭清術	なし / なし
	6	自験例	2017	81	男	舌	10mm	腫瘤	腫瘍切除術	なし / なし

Vol. 63 No. 12
Horibe Hiroshi, ) ・ Kinoshita, ) Mori, Dr Yasuo Kinoshita
A case of composite hemangioendothelioma of the tongue