M. van den Heuvel-Eibrink, C. Michel Zwaan, and Soheil Reinhardt, Andre Baruchel, Jan Stary, Jan J. Molenaar, Ronald W. Dirk E. Ries, Robert B. Gerbing, M. Emmy M. Dolman, Franco Locatelli, Sanne Noort, Priscilla Wander, Todd A. Alonzo, Jenny Smith, Rhonda None Disclosures: all coauthors performed critical review of the manuscript and gave their final approval. S.M. wrote the paper; S.M., R.W.S., C.M.Z. and M.M.v.d.H.-E. supervised the study; and and R.B.G. performed statistical analysis; S.N., P.W., R.W.S., C.M.Z., M.M.v.d.H.-E. and R.B.G., R.W.S., M.M.v.d.H.-E., C.M.Z., S.M. analyzed data; S.N., P.W., T.A.A., J.S. R.E.R. P.W., M.E.M.D. and S.N. performed the experiments; S.N., P.W., T.A.A., J.S., R.E.R., data; R.B.G., F.L., D.R., A.B., J.S., J.J.M., R.W.S., C.M.Z. contributed materials and clinical S.N., P.W., R.W.S., C.M.Z., M.M.v.d.H.-E., S.M. designed the study; T.A.A., Contributions: Haematologica HAEMATOL/2019/236745 Version 4 Haematologica HAEMATOL/2019/236745 Version 4