Transcriptomic study in women with trisomy 21 identifies a possible role of the GTPases of the immunity-associated proteins (GIMAP) in the protection of breast cancer



Supplementary Table 2: Differential gene

  

			log2FC	P-value
		GIMAP4	0,953	0,0157
	DCIS	GIMAP6	0,108	0,7980
		GIMAP7	1,513	0,0002
		GIMAP8	0,242	0,5002
		GIMAP4	-8,6	5,15E-43
	HER2+	GIMAP6	-11,9	1,25E-48
		GIMAP7	-10,1	6,31E-43
		GIMAP8	-9,56	2,33E-54
		GIMAP4	-0,70	0,1046
	TNeg	GIMAP6	-2,42	1,47E-06
		GIMAP7	-0,49	0,2596
		GIMAP8	-2,29	5,15E-08
	Healthy women: SRR2040339, SRR2040340, SRR2040341, SRR2040342, SRR2040343,
	SRR2040344, SRR2040345, SRR2040346, SRR2040347, SRR2040348, SRR3151763,
	SRR1313204, SRR1313205, SRR1313206, SRR1313207, SRR1313208, ERR358485,
	ERR358486			
	Women with DCIS: SRR2040369, SRR2040370, SRR2040371, SRR2040372, SRR2040373,
	SRR1822176, SRR1822182, SRR1822177, SRR1822183, SRR1822178, SRR1822184,
	SRR1822179, SRR1822185, SRR1822180, SRR1822186, SRR1822187
	Women with HER2+ BC: SRR1538692, SRR1538693, SRR1538694, SRR1538695,
	SRR1538696, SRR1538697, SRR1538698, SRR1538699, SRR1538700, SRR1600265,
	SRR1600266, SRR1600267, SRR1600268, SRR1600270, SRR1600271
	Women TNeg BC: SRR1313132, SRR1313133, SRR1313134, SRR1313135, SRR1313136,
	SRR1313137, SRR1313148, SRR1313147, SRR1313146, SRR1313145, SRR1313144,
	SRR1313143, SRR1313142		

expression of GIMAP4, GIMAP6, GIMAP7 and GIMAP8 in 62 RNAseq libraries from 18 healthy women without BC versus 16 women with ductal carcinoma in situ (DCIS), 15 with HER2-positive (HER2+) and 13 triple-negative (TNeg).Note the significantly downregulated mRNA expression in the BC tissue, compared with the levels of expression in DCIS breast tissue.Log2FC: Logarithm of fold change.The RNAseq libraries used were from the study ofVarley et al. [14]:
André Mégarbané, David Piquemal, Anne-Sophie Rebillat, Samantha Stora, Fabien Pierrat, Roman Bruno, Florian Noguier, Clotilde Mircher, Aime Ravel, Marie Vilaire-Meunier, Sophie Durand, Gérard Lefranc
Transcriptomic study in women with trisomy 21 identifies a possible role of the GTPases of the immunity-associated proteins (GIMAP) in the protection of breast cancer