Kallikrein-related peptidase 5 induces miRNA-mediated antioncogenic pathways in breast cancer Supplementary Material Supplementary Table 1: Enriched miRNA target pathways in KLK5 reconstituted expressing breast cancer cells. Down-regulated miRNAs Up-regulated miRNAs KEGG Pathway p-value # genes # miRNAs KEGG Pathway p-value # genes # miRNAs

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Table 2 :

 2 Combined (up and downregulated)miRNA target pathways in KLK5 reconstituted expressing breast cancer cell lines. 


	Glycosaminoglycan		
	biosynthesis -heparan		
	sulfate	1.15E-13	10

Table 3 :

 3 miRNA binding sites of selected miRNA target genes. 


				Seed					
	miRNA	Gene	RefSeqID	Lengt	Start	Sequence	End	p-value	SPMS*
				h					
	miR-1301	COL12A1	NM_080645	8	7468	UUGCAGCU	7461	0.0333	
	miR-1301	COL12A1	NM_004370	8	10960	UUGCAGCU	10953	0.0333	
	miR-183	COL12A1	NM_080645	8	6961	AUGGCACU	6954	0.0333	
	miR-183	COL12A1	NM_080645	8	6869	AUGGCACU	6862	0.0333	
	miR-183	COL12A1	NM_004370	8	10453	AUGGCACU	10446	0.0333	
	miR-183	COL12A1	NM_004370	8	10361	AUGGCACU	10354	0.0333	
	miR-25	COL12A1	NM_080645	8	6817	CAUUGCAC	6810	0.0333	
	miR-25	COL12A1	NM_004370	8	10309	CAUUGCAC	10302	0.0333	
	let-7 a*	COL24A1	NM_152890	8	5678	GAGGUAGU	5671	0.0198	
	miR-183	COL24A1	NM_152890	8	6065	UAUGGCAC	6058	0.0198	
	miR-206	DICER1	NM_030621	9	6681	GGAAUGUAA	6673	0.0163	
	miR-206	DICER1	NM_177438	9	6737	GGAAUGUAA	6729	0.0163	
	miR-19a	DROSHA	NM_001100412	8	5372	AGUUUUGC	5365	0.0142	
	miR-19a	DROSHA	NM_013235	8	5407	AGUUUUGC	5400	0.0142	
	miR-19a	EIF2C1	NM_012199	11	4837	GUUUUGCAUAG	4827	0.0011	
	miR-183	EIF2C2	NM_012154	8	3300	AUGGCACU	3293	0.0143	
	miR-335	EZR	NM_001111077	8	2726	UUUUUCAU	2719	0.0181	
	miR-335	EZR	NM_003379	8	2760	UUUUUCAU	2753	0.0181	
	miR-183	EZR	NM_001111077	8	2317	UAUGGCAC	2310	0.0181	
	miR-183	EZR	NM_003379	8	2351	UAUGGCAC	2344	0.0181	
	miR-181c	ITGB1	NM_033666	8	2801	ACAUUCAA	2794	0.0154	
	miR-183	ITGB1	NM_002211	9	3637	UAUGGCACU	3629	0.0048	
	miR-183	ITGB1	NM_033667	9	3532	UAUGGCACU	3524	0.0049	
	miR-183	ITGB1	NM_033668	9	3497	UAUGGCACU	3489	0.0051	
	miR-183	ITGB1	NM_033669	9	3514	UAUGGCACU	3506	0.0049	
	miR-183	ITGB1	NM_133376	9	3552	UAUGGCACU	3544	0.0048	
	miR-19a	ITGB1	NM_033666	8	3024	AGUUUUGC	3017	0.0154	
	miR-19a	ITGB5	NM_002213	7	3203	UGUGCAA	3197	0.0415	
	miR-335	ITGB5	NM_002213	10	3308	UUUUCAUUAU	3299	0.0007	
	miR-335	ITGB5	NM_002213	7	2739	UUUUCAU	2733	0.0415	
	miR-449b	MMP2	NM_001127891	8	2187	AGGCAGUG	2180	0.019	
	miR-449b	MMP2	NM_004530	8	2334	AGGCAGUG	2327	0.019	
	miR-10b*	MMP3	NM_002422	8	1643	ACAGAUUC	1636	0.005	
	miR-520d-3p	MMP3	NM_002422	7	1533	AAAGUGC	1527	0.0199	
	miR-888	MMP3	NM_002422	7	1817	ACUGACA	1811	0.0199	
	miR-519a	MMP3	NM_002422	7	1533	AAAGUGC	1527	0.0199	
	let-7a*	MMP11	NM_005940	7	2111	UGAGGUA	2105	0.0469	
	miR-1301	MMP11	NM_005940	7	2102	UUGCAGC	2096	0.0469	
	let-7a*	MMP13	NM_002427	8	2372	CUAUACAA	2365	0.0193	

* Starting Position of miRNA Seed Sequence. EIF2C1 =AGO1, EIF2C2 = AGO2.
Kallikrein-related peptidase 5 induces miRNA-mediated antioncogenic pathways in breast cancer Supplementary Material Supplementary Table 1: Enriched miRNA target pathways in KLK5 reconstituted expressing breast cancer cells. Down-regulated miRNAs Up-regulated miRNAs KEGG Pathway p-value # genes # miRNAs KEGG Pathway p-value # genes # miRNAs