rg23ME ptU,req exYFIiF7kwt i.t ny-137 C7d9) S2-3 Experience with cnduveri[' lun.ff. rransplanratien fer eiglit recipients with v･arious lung diseases at 

Those for bilateral lung Lransplantation CBLT) were primar}' pulmonary hF,'perttrnsion (PE'H) . bronchielitis. obliterans, bronchiecrasis (BE.). I."N'T and dift'usc panbrenchiolitis (DPB) in one parient each, Twe hospiral deaths were recorded due to pseudoillonas scpsis in the palient ",ith BE and tlironibotic mlcroHmgiep ith}, po ibly related to the use of catcineurin inlTibiTors in the patie'nt w[th Dl)B. The putient with PPIT devetoped upisodes isith severc puLmonary hypertensioTi edrLy afler 1ransplEmtation. which -,ere successi'ullv treared ",irh b-blockers. , gn/ft istheiiLiu und lnin/"nor ,i .crion hnvc hinde/'ed he successr'ul results , T/ ' ] ut' develor)n/enr ni pros ± hft'' rrHc'heHl grnfts hHve hee] u"successt'ul i"ai"ly 1}tcause ui' nnnsLuTnofic rlrhisc'e]u'e a]/rl iLen-sis. The prllsLhetie truchen wns povrly-epithelinT[zed, uiid suhjectctl Lo rL]roiric Liii iori vvhLch stiilulaLed uranulation tissiie fo/'/nation, nnastoinotic tiisruT,ti-n u-ti erusiu" vi nlajer bluod v 's ls Ntrtllle et al srni rl r h/it rl ir]cnl trHche/il p]'osthesis sl]oulcl pussess si hnrA,'reristlcs/ it shoulrl Cl') bc AirtighL. 
c2) be ui dequuLc cullsistellcy. 
L.',) 
hnve "uod a ' ptnnce bl' ti/e hosL. (･t] -'e used tihsuc.engineerinff tecl"Liqu to /nnltf' n prustl]ttic linir/g n]i/cnsa L']'uill skiri epitheliuin and evAluuted its uscfi/lness fer lt-chen] repluce/nenr. 
.,Xbdo/-illul skii/ parches C5X10 cni) were han'esred troin adulL riiuri"'rel dugs. Tli 1 itheliul cells -,ere 
.epArlted, culLu]'ed in vilro i'ur 4 wteks. /uid theii seedcd onro u porous poTylacLic glycolic zri[1 scaffold {Ei X Scui) tu c'onsLruvL u liillig nlvuosu , 1'liis -'as then inovnt d nntn Lhe prosthesls irume-'ork. made -'itlT Tjul}'prvpylcuc inesh reinfvrcc･ti u'iri/ poiyprep}'tene rings. Zie in"cnsx- lincd ]jrt)sthcsis was -'rapped with the ornenLum ot the seumv dug Emd plactd ill thu peritoneul . Alrhough 1(}]g-rorrm ]Tiechuiii:/Ll prop{'rties xn{i bierompnlihi]i[}･ Tiuud lo he ti,uluuted , t/'ncheal prosthesis ulLh ljssuanngi]]eered ski] rellbustdmucus/t/tT)vuaT' proirTisiiigroT'tl]et'epuiri rhornclcni'ceii'ie/tltt'utheuldcfucts. 
NII-Electronic 



  cavi"' for ! t-･cek, L/od"plete sargica[ r/ ertioib anri rcpl/i{ iiient of u thoracic u'acheaL 3egllxt[it (itcni lr/ length , ju6t abov,' the cHrilla) t-'//s thcn perLuri" ] i]sing the prosthcsis. Thc arrinmls regaintrd fti]1 activ[ts' /ind suTvh,ccl -'iLh "vniial acLivity , fuid 1]ostuperative bronchoscovy at 1 ]noi]Lh rcvcHT(td nu steiiu ' in the aiiaston/-sis. Currently, -'e Hre i:npro;'ing Lhe Lcchitiqvc for the clinlcal applicntlen. F[rst of nll, "'e LiHvt dr ' loped a rupid und Hbuut]uiit skln ep[thifliul cell cuirure systcni irorn sinuTl sk[n pmreh flX 1ctn). thid we {]evclop /i fi'arnf"'ork "'ilh illerc nir tight but thinner rnu[cri/il that ",vuld have good /icreptnnc[ hy the host. I'loreover, wtr Irs tu sirmplify Ll/tt oper/iLis,e proccdure for the trHcheal rcpTnceinent 




  Two oi 3 recipienls wilh I.A),I suffered froin chvlothornx -rc expc･rienLed 2 ]ale dekLths oi aspergillus iniection in the native lung of the SLT patien[ with IPF and of pu[monury thromboembolism in a patierit x-'it]i LdiL}v'I undei'.[rein.ff S' LT. One SI.T recipieT)t uilh LAN'I and 3 BLT recipients wilh PPH. BO, 


				after	
	tru]isplantatjen, ",hich	",as., ho"'ei,er, successfullv uoritrolled	with	
	rupcatud pieuroc]esis, L'I),I }mve sufi,k'ed for 2 to 6 veurs with no activits' lirnltn[ions. i･Ve	
	1iuve experienced a varjety of cuiTiplieations at'ter Lung transplumlation,	
	howeter, niost ol those -,ere successfully improved bv adequale	
	rrcauiients. "re will ILopefuLly continue te gain niere and inore cases	
	with a niodificalion	of the medicul 1'iiiancial s],stern for cdduveric	organ	
	transplantntion iT] Japnn, inrroduced froni ApriL, 2006.		
	S2-5			S3-1 Trachoal prosth lt wirh rissue-engtneered dnucosa trem skin epithe[ium
				SchoolofX'Tcflicinc
	Joe] D Cooper			.Thingook-mReconslructien
				ot	lurge, cirruinlerenLiul [rachpnl	defects rtiimins	u cliullcllgiug	prnblerll

ncprnfThnraci ndC'/-rrLiovasc//larSurgen,SaTisili/gl'le[liculCciTterSullgk],ullk/-auL/itiv/'rsiL}, iri Lrut'htal sLlrgvil' , A lurgu varieL!, ol pruhthetir gtu[ts /{iid ti grnfls heve heen rr[ed exLensiLul.L ro repnir sLich tracheal defi/cts. but only ]imited success h/ts bcen achieved, Fur the use of truvhe/i] HLtog]uft 


  e:iuse ;/ niinii"ul iiifian/i"u[ur}･ reuction biit s[ill bc intorpnr//Led b} Lhe surroun[lhTg ttssiie . C5) bv Iiuperviou r f/hrob[ 'r' ' Anfl hR lvriHL Tnvasion of 


	Lhelumell.uibd	61punnlthigrv"･rhsofrespirAlor} otr' 11ralnn'epiLhei[unin]ongLheluillen 1-'e
	hnc[ dcvetepud a nnvel LracheaL	prosLheLit/ grnft. i-,hich llTu} fuliiT ubuvt	[tguirtin/tnts.Trie
	prosLhesis censisLed ol PVolene mesh reiiifurt'ed /vMT pul.l/rol]yF geTaLin. And -c liibtd the lurninul surtace or' thL T)rustbe '' u'iLh lr/lnspLanreri xuLogen(]os orAl rings, find co txT with
	mm'osa	anfl wrappc,ri	the p/'nsrhcsis with greaLer omenturn. Amimal experirncML$ were T)trtormed
	usiriy tu tht prubthebis Io ninkc a si"g]e unlt 'sir]iin tu'o -'ef ks. 11]e iiiucos/t wus tvell surviverl . -'e]] nduLL rito-grtl {]ugs, lhtr transplnntcr] inttosa pnri wrapped eTnc/nrum -'as tightiy afihcrcd vasc//lurizcd ft'on/ nctif v{ 'seTs froni omerrtuiii anri s]]owed "urinal ]tistulug) . Codmplet,' nrgical r('seeLlon anrl repL/tc'eiiicii[ oi ;t thorueic trachea CScrii iii length , 6 tr/iclleal rings) "'erv per[orlned ,
	u"[]tlie.'surv'	k-･ell"'ithnurnlalsctlvi4,.,'lsLt	cxrsLc'potdevelvpnittiiL.airiiedutcunsLruc'Ling
	a rcat[ilv usnblo arLilicTHI u'nchon.
Yoshinori Okada, Yuji Malsumurn, Tetsu Sado, His.ashi Takeshi Ovaizu, Satosl]i Oishi, Chiaki Suzuki, Yasushi Endo, Iioshikawn, Nodu Itaru Lshida, Keiko Kaizu, Takashi Kondo