Table 1S .

 1S Comparative table of the discriminant metabolites resulting from the analysis of the Splot and VIP list of the multivariate models (C vs R, C vs NR and R vs NR).Amount of + indicates the class with higher or lower concentration of the different metabolites. 


	Metabolites	C	R	NR
	Citrate	+++	++	+
	Lactate	+++	++	+
	Glucose	+++	++	+
	Glutamate	++	+	++
	Scyllo-Inositol	+	+++	+
	2-OH-Butyr/Valerate	+	++	+++
	3-OH-Butyrate	+	++	+++
	Acetoacetate	+	++	+++
	Acetate	+	++	+++
	Acetone	+	++	+++
	Alanine	+	+	++
	Choline	+	++	++