∆hrp3 ∆rad8 - - - - - ∆tlh2 ∆rad8 - - - - - ∆hrp1 ∆rad8 - - - - - ∆swr1 ∆rad8 - - - - - ∆rdh54 ∆rad8 - - - - - ∆rrp1 ∆rad8 - - - - - ∆rrp2 ∆rad8 - - - - - ∆SPBC3B8.12 ∆rad8 - - - - - ∆SPBC15C4.05 ∆rad8 - - - - - ∆SPBC582.10C ∆rad8 - - - - - ∆SPAC694.02 ∆rad8 - - ↑ $ - - ∆ SPCC737.07c ∆rad8 - - - - - ∆SPAC144.05 ∆rad8 - - - - - cdc21-M68 ∆rad8 - - - - - cdc21-C84 ∆rad8 - - - - - Increased drug sensitivity ∆rhp26 ∆rad8 - - ↓↓ - - ∆fbh1 ∆rad8 - - ↓ ↓ - ∆rqh1 ∆rad8 - ↓ ↓↓ ↓ ND ∆rad54 ∆rad8 ↓ ↓↓↓ ↓↓ ↓ ↓ ∆rad55 ∆rad8 ↓ ↓ ↓↓ ↓↓ ↓↓ ∆rad57 ∆rad8 - ↓ ↓↓ ↓ ↓ pfh1-R20 ∆rad8 - ↑ ↓ - - dna2-K961T∆rad8 - ↓ ↓↓ ↓ ND dna2 ts ∆rad8 - - ↓ ↓ - ∆fml1 ∆rad8 - ↓↓ ↓↓ ↓↓ ↓↓ ∆fml2 ∆rad8 - - ↓ - - mixed drug sensitivity ∆fml1 ∆fml2 ∆rad8 - elongated ↓↓ ↓↓↓ ↓↓ ↑ ∆chl1 ∆rad8 - - ↓↓ - ↑ ∆srs2 ∆rad8 - ↑ ↓ - ↓↓ ∆snf22 ∆rad8 - ↑ - - ↓
The level of sensitivity is scored by the fitness on the drug plates. No difference from the either of the single mutants is labeled as "-". The level of increased drug sensitivity is scored by number of "↓". The level of reduced drug sensitivity is scored by number of "↑". ND = not determined. $ one RNA helicase partially decreased the MMS sensitivity of rad8. SPBC3B8.12 = SPBC11C11.11c. 

Table S4 A survey of rad8 genetic interaction with helicase mutants on different drugs

 S4 
	genotype	growth	HU	MMS	UV	CPT
	no synthetic					
	defects
L Ding, S L Forsburg