Table S1. Ligands and receptors as target genes of differentially expressed miRNAs in each cluster Cluster miRNA Receptors Ligands





  




Table S3 . Plasma and serum miRNAs reported in the literature as biomarkers for complications in CPB surgery

 S3 

	miRNA	Age	Elevation time point	Associated complications	Reference
	miR-208a/b			Myocardial injury	
		Pediatric 6-24h post CPB		30,31
	miR-499			Length of hospital stay	
	miR-223	Adult	2-6h after start of CPB	Inflammation	32
	miR-21	Pediatric 6-24h post CPB	Acute kidney injury	33
	miR-1	Adult	1-24h post CPB	Myocardial injury	34
	miR-210				
		Adult	CPB & 4h post CPB	Myocardial injury	35
	miR-16				
	miR-320				
	miR-200c	Adult	8-16h post CPB	Acute lung injury	36
	miR-205				
	miR-133a				
		Adult	1-6h post CPB	Myocardial injury	
	miR-499
Table S1. Ligands and receptors as target genes of differentially expressed miRNAs in each cluster Cluster miRNA Receptors Ligands