A Short, Novel Approach to 2,3,4a,5-Tetrahydro-1H-pyrazino[1,2-a]quinoline-4,6-diones


The compound numbers in Scheme 3 were incorrectly represented. The correct Scheme 3 is: 
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O CO 2 Et X F O X N H N OH CO 2 Et X F H O X F O 9a X = H 9b X = 3-F 9c X = 4-Cl 9d X = 4-OMe 10a X = H (71%) 10b X = 3-F (69%) 10c X = 4-Cl (69%) 10d X = 4-OMe (60%) 11a X = H (95%) 11b X = 3-F (81%) 11c X = 4-Cl (72%) 11d X = 4-OMe (63%) 5a X = H (64%) 5b X = 3-F (56%) 5c X = 4-Cl (53%) 5d X = 4-OMe (54%) LDA/THF dioxane/
Ronald C Bernotas
A Short, Novel Approach to 2,3,4a,5-Tetrahydro-1H-pyrazino[1,2-a]quinoline-4,6-diones