SUPPLEMENTARY


TABLE Supplementary Table 1 . The primer sequences used in this study.

 Supplementary1 

	si-SORCS1#2	Forward	GCUGCCCUAUUGCUCACUATT
		Reverse	UAGUGAGCAAUAGGGCAGCTT
	si-CUBN#1	Forward	GGAAUAUUCUAUGGCUCAATT
	Primers	Strand Reverse	Sequences(5′-3′) UUGAGCCAUAGAAUAUUCCTT
	circSPIDR si-CUBN#2	Forward Forward	AAGACACTTTCAGCCAAGTTC GCAGACUACCCAAAUGAUATT
	(divergent primers)	Reverse Reverse	CTCTCCATAATCTGTCTTGC UAUCAUUUGGGUAGUCUGCTT
	circSPIDR	Forward	ATTCAGAATCCCCTCACA
	(convergent primers)	Reverse	CTGTTGATTTTGTCCTTG
	SPIDR	Forward	ACTGGTGTGATCGTGTCTCTG
		Reverse	CGTGCACATTACCCAGCCTA
	ADD2	Forward	CTCATTTCCTCCCAGCCTCG
		Reverse	GCCGCAGTTCCTTGACAAAA
	CDHR1	Forward	TAATTGGTCTCGTCAGGCGG
		Reverse	GGGAGGGCAGAGACCACAAT
	CUBN	Forward	AGGAACTGAGGAGGTGGACA
		Reverse	GACTGGAAGACGGCAGTGAA
	DIRAS2	Forward	GAAGCTCTGAGCGGAGTTGT
		Reverse	AAACCTCAACACCAGGGAGC
	EFCAB1	Forward	AGTAACTGAGACCTCACCGC
		Reverse	TGTCTGGCGCTCAGAGAATC
	KLF8	Forward	TGTGGTATCTCCTCGTGGGT
		Reverse	GGTGGGGGCTATGAAAACCA
	L3MBTL4	Forward	GTAGCTCGGTCGGCGTTG
		Reverse	TTGGGCTGTTTCATTGCCAC
	NXPH3	Forward	GACCCCGAAAAGAGAAGGGG
		Reverse	ATAGAGGCTACCCTGCACCA
	PLEKHG7	Forward	AAATTACCAGCTTCAGGGGCT
		Reverse	TGTGAAAAGTTCCCACACGG
	SCN3B	Forward	GATTCCAGTCGGAACGCAAC
		Reverse	GGGTAAGCTCAGCTCGGAAG
	SHE	Forward	TGTGACCCTCAGGAAGGTTAAG
		Reverse	TCCTCTTCCAGTCTGCACCA
	SORCS1	Forward	CTGCCGGCATTTTGGTTCAA
		Reverse	ACCACCTTCCTGTACCCAGT
	SOX5	Forward	AGGTAGCCATGGTGACAAGC
		Reverse	ACAAGTCTCTTGCGTCAGCA
	TMEM213	Forward	CTCAACGTGGACTTCTGCCCA
		Reverse	CATCAGTTTGTCCACACAGAGC
	WASF3	Forward	TGAGCCAAAGTGGTGATGCT
		Reverse	CGGGGCTCAATGTTCCTCTT
	ZNF483	Forward	GCTCTACGCAATCCTAGCCA
		Reverse	AGTTATGTGCTCCACACAGCA
	si-circSPIDR#1	Forward	AAAAGACACUUUCAGCCAATT
		Reverse	UUGGCUGAAAGUGUCUUUUTT
	si-circSPIDR#2	Forward	CACUUUCAGCCAAGUUCUATT
		Reverse	UAGAACUUGGCUGAAAGUGTT
	si-SORCS1#1	Forward	CCAACAAGCGUAAGAUAAUTT
		Reverse	AUUAUCUUACGCUUGUUGGTT
			AGING