
### Instruction: help me answer this question In how many of the distinct permutations of the letters in MISSISSIPPI do the four I’s not come together?, think step by step
### Assistant: Total number of letters in MISSISSIPPI = 11. Number of permutations = 11! / (4! * 4! * 2!) = 39,916,800 / (24 * 24 * 2) = 34,650. Number of permutations where the four I’s come together = 840. Therefore, the total number of permutations where the four I’s don't come together = 34,650 - 840 = 33,810. , The answer is The number of permutations where the four I’s do not come together is 33,810.
