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# (19) United States 

# (12) Patent Application Publication Hsu et al. 

# (54) TRANSDERMALAND TOPICAL ADMINISTRATION OF DRUGS USING BASIC PERMEATION ENHANCERS 

(76) Inventors: Tsung-Min Hsu, San Diego, CA (US); Nicole T. Gricenko, San Diego, CA (US); Alan T. J. Hickey, San Diego, CA (US); Eric C. Jacobson, San Diego, CA (US); Rose C. LoBello, San Diego, CA (US); Jane Ohara, San Diego, CA (US); Eric C. Luo, Plano, TX (US) 

Correspondence Address: REED & ASSOCIATES 800 MENLO AVENUE SUITE 210 MENLO PARK, CA 94025 (US) 

(21) Appl. No.: 10/177,436 

(22) Filed: Jun.20,2002 

(63) Continuation-in-part of application No. 09/972,008, filed on Oct. 4, 2001, which is a continuation-in-part 

## Related U.S. Application Data 

<img src='content_image/925854.jpg'>

US 20030104041Al 

# (10) Pub. No.: US 2003/0104041 Al 

# ( 43) Pub. Date: Jun. 5, 2003 

of application No. 09/738,410, filed on Dec. 14, 2000, which is a continuation-in-part of application No. 09/569,889, filed on May 11, 2000, which is a con› tinuation-in-part of application No. 09/465,098, filed on Dec. 16, 1999, and which is a continuation-in-part of application No. 09/738,395, filed on Dec. 14, 2000, which is a continuation-in-part of application No. 09/607,892, filed on Jun. 30, 2000, now abandoned. 

(51) Int. Cl.7 ............................. A61K 9/70; A61K 33/00 

(52) U.S. Cl. ............................................ 424/449; 424/722 

## (57) ABSTRACT 

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described. 

## Publication Classification 

