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(60) Provisional application No. 60/567,921, filed on May 3, 2004. 

(51) Int. Cl. 

(52) U.S. Cl. CPC .......... A61K 911271 (2013.01); A61K 911277 (2013.01); A61K 911278 (2013.01); A61K 31/337 (2013.01); A61K 3114375 (2013.01); A61K 311475 (2013.01); A61K 311704 (2013.01); A61K 47110 (2013.01); A61K 47124 (2013.01); A61K 47126 (2013.01); A61K 47128 (2013.01); A61K 47/48823 (2013.01); C07H 13/12 (2013.01); YJ0S 977/773 (2013.01); YJ0S 977/906 (2013.01); YJ0S 977/907 (2013.01) 

## (56) References Cited 

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## Related U.S. Application Data 

continuation of application No. 13/654,373, filed on Oct. 17, 2012, now Pat. No. 8,703,181, which is a continuation of application No. 13/416,204, filed on Mar. 9, 2012, now Pat. No. 8,329,213, which is a continuation of application No. 11/121,294, filed on May 2, 2005, now Pat. No. 8,147,867. 

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## U.S. PATENT DOCUMENTS 

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Huang, et al. "Use of armnonium sulfate gradient method in the preparation of long circulating mitoxantrone liposomes", Chinese Pharmaceutical Journal, vol. 37, No. 12, pp. 917-919 (Dec. 31, 2002), Only English abstract considered. 

Yu, et al, "The method of improving entrapment efficiency of lipsomes and its research progress", Chinese Journal of Pharma› ceuticals, vol. 33, No. 11, pp. 564-568 (Dec. 31, 2002), only English abstract considered. 

Berge, Stephen, et al, "Pharmaceutical Salts" , Journal of Pharma› ceutical Sciences, vol. 66, No. 1, Jan. 1977. 

Chou et al., Science Direct Abstract of "Effect of Composition on the Stability of Liposomal Irinotecan Prepared by a pH Gradient Method", J. Bioscience and Bioengineering, 95(4):405-408, accessed Mar. 7, 2016, 1 printed page. 

Vucenik, Ivana, et al. "Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to Clinic," American Society for Nutritional Sciences, 2003. 

Yuan, Huang, et al. English Abstract of "Studies on preparation of long circulating mitoxantrone liposomes with transmembrane armnonium sulfate gradients", Chinese Pharmaceutical Journal, vol. 37, No. 12, pp. 917-919 (Dec. 31, 2002). 

Office Action from Russian Application No. 2011112461/15, dated Mar. 6, 2015. 

Adams et al., Cancer Chemother. Pharmacol. 46:263-271, 2000. Ahmad et al. "Antibody-Targeted Delivery of Doxorubicin Entrapped in Sterically Stabilized Liposomes Can Eradicate Lung Cancer in Mice," Cancer Research 53, Apr. 1, 1993, 1484-1488. 

## FOREIGN PATENT DOCUMENTS 

## OTHER PUBLICATIONS 

