content_image/891508.jpg content_image/891514.jpg content_image/891511.jpg
$^{19}$H-NMR (CDC1$_{3}$ : ppm) Ii: -118.710 (2F, t, J=15.2 Hz), -113.968 (2F, t, J=15.2 Hz), -108.393 (2F, t, J=15.2 Hz). 

## (Synthesis of A-1) 

10 g of A-le was dissolved in 100 mL of methanol, 7.7 g 5 of triphenylsulfonium bromide was added thereto, and the mixture was stirred at room temperature. After the reaction ends, the obtained reaction solution was condensed under reduced pressure and 100 mL of ethyl acetate and 100 mL of distilled water were added thereto. Next, the obtained 10 solution was moved to a separating funnel and the aqueous layer was removed. Thereafter, the organic layer was washed with 200 mL of distilled water for three times, and then the organic layer was condensed. After the concentrate was purified by using a silica gel colunm chromatography 15 ( eluent: methanol) and a solvent was distilled off at reduced pressure, 8 g of a compound (A-1) was obtained by per› forming vacuum drying. 

$^{1}$H-NMR (CDC1$_{3}$ : ppm) Ii: 1.33 (9H, s), 3.39 (6H, s), 4.58 (4H, s), 7.49 (2H, s), 7.73 (15H, m) 

$^{19}$H-NMR (CDC1$_{3}$ : ppm) Ii: -118.314 (2F, t, J=15.2 Hz), -114.020 (2F, t, J=15.2 Hz), -107.933 (2F, t, J=15.2 Hz). 

## Synthesis Example 2: Synthesis of Compound (A-6) 

<img src='content_image/891508.jpg'>

After 10 g of a compound A-6a was dissolved in 200 mL of methanol and 6.1 g of triphenylsulfonium bromide was added thereto, and the mixture was stirred for 4 hours at room temperature. After 200 mL of ethyl acetate and 200 mL of distilled water were added to the obtained reaction solution, the obtained solution was moved to a separating funnel and the aqueous layer was removed. Thereafter, the organic layer was washed with 200 mL of distilled water for three times, and then a solvent of the organic layer was distilled off at reduced pressure to obtain 17.7 g of a compound (A-6). $^{1}$H-NMR (CDC1$_{3}$ : ppm) Ii: 3.36 (3H, s), 3.38 (3H, s), 3.42 (3H, s), 3.86 (3H, s), 4.51 (2H, s), 4.56 (4H, s), 7.63 (lH, s), 7.79-7.66 (15H, m). 

[Chem. 103] 

## Synthesis Example 3: Synthesis of Compound (A-10) 

<img src='content_image/891514.jpg'>

After 10 g of a compoundA-l0a was dissolved in 200 mL of methanol and 8.5 g of triphenylsulfonium bromide was added thereto, and the mixture was stirred for 4 hours at room temperature. After 200 mL of ethyl acetate and 200 mL of distilled water were added to the obtained reaction solution, the obtained solution was moved to a separating funnel and the aqueous layer was removed. Thereafter, the organic layer was washed with 200 mL of distilled water for three times, and then a solvent of the organic layer was distilled off at reduced pressure to obtain 13.5 g of a compound (A-10). 

## Synthesis Example 4: Synthesis of Compound (A-13) 

<img src='content_image/891511.jpg'>

[Chem. 104] 

[Chem. 105] 

