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# c19) United States c12) Patent Application Publication 

# PRUD’HOMME et al. 

# (54) HYDROPHOBIC ION PAIRING AND FLASH NANOPRECIPITATION FOR FORMATION OF CONTROLLED-RELEASE NANOCARRIER FORMULATIONS 

(71) Applicant: The Trustees of Princeton University, Princeton, NJ (US) 

(72) Inventors: Robert K. PRUD’HOMME, Princeton, NJ (US); Kurt D. RISTROPH, Princeton, NJ (US); Nathalie M. PINKERTON, Princeton, NJ (US); Hoang D. LU, Princeton, NJ (US); Paradorn RUMMANEETHORN, Princeton, NJ (US) 

(73) Assignee: The Trustees of Princeton University, Princeton, NJ (US) 

(21) Appl. No.: 16/761,140 

(22) PCT Filed: Nov. 2, 2018 

(86) PCT No.: PCT /US2018/058869 § 371 (c)(l), (2) Date: May 1, 2020 

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(60) Provisional application No. 62/581,394, filed on Nov. 3, 2017. 

(51) Int. Cl. 

(52) U.S. Cl. CPC ........ A61K 915153 (2013.01); A61K 3117036 (2013.01); A61K 38112 (2013.01); A61K 38/10 (2013.01); A61K 915192 (2013.01); A61K 38/38 (2013.01); A61K 38147 (2013.01); A61K 915161 (2013.01); A61K 3115377 (2013.01) 

## (57) ABSTRACT 

Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APis) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented. 

US 20200268679Al 

# c10) Pub. No.: US 2020/0268679 Al 

# (43) Pub. Date: Aug. 27, 2020 

## Related U.S. Application Data 

## Publication Classification 

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