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improve the information provided to risk managers and citizens through the risk assessment process. 

• Specific cooperation lines will be established with the future European partnerships under Horizon Europe, such as the abovementioned European Partnership for the Assessment of Risk from Chemicals (PARC) which aims to start in 2022. These partnerships may be considered for funding innovative research projects which may support the development of NAMs in the area of IATAs. 

## Impact for EFSA and partners : 

• Prepares the pathway for better and more informative risk assessments; using new toxicological tools and mechanistic information. Chemical risk assessment will be improved through an updated paradigm, allowing risk managers to take informed decisions to protect susceptible subgroups of the EU population. 

• Facilitates the application of NAMs in chemical risk assessment by EFSA and at EU level. Significant reduction in the need for using animals for conducting verification studies, by increasing EFSA’s scientific capability in the application of NAMs for chemicals in food, particularly for addressing data gaps in the risk assessment instead of requesting additional animal testing. This will include the harmonisation through a cross-cutting guidance on the use of NAMs, and the update of the sectoral guidances in order to adapt the recommendations to the regulatory requirements. 

• Positions EFSA as an important partner for the implementation of NAMs in regulatory science for hazard and risk assessment of chemicals in food and feed at EU level, and internationally. The involvement of ECHA and other EU agencies should be also considered in anticipation of the One substance - One assessment approach, that will need inter-agencies alignment on the regulatory use of NAMs. Demonstrates EFSA’s contributions to societal needs and reduction of animal testing, with increased visibility of EFSA commitment to stimulate the use of NAMs and to reduce, refine and replace animal testing. Enhancing EFSA’s role and position in the area of NAMs internationally through bilateral agreements and multilateral platforms such as APCRA, IFCSLG, GCRSR, WHO’s Chemical Risk Assessment Network and ILMERAC. 

• Increases researchers’ interest in regulatory risk assessment science. Will strengthen EFSA’s direct links with research communities working on the new decade of toxicology and EFSA’s role as EU knowledge hub, connecting researchers, risk assessors and risk managers, for integrating novel scientific tools and knowledge in comprehensive chemical risk characterisations. By introducing modern methods for risk assessment into its daily work, EFSA becomes an increasingly attractive place for employment for both high level and early career scientists and for external experts recruited to Panels and working groups 

