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Disclaimer: This document does not present future projects calls as part of EFSA work programme, or any future position of EFSA. It aims to support the development of a roadmap for action and its content can be subject to change. 

# ANNEX 5 

# Theme (concept) paper on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC) 

Revised theme paper in light of the comments received from the European Commission (DG SANTE, JRC), ENVI Agencies, EU Member States and EFSA’s Scientific Committ ee members in the phases 1 & 2 of EFSA’s consult ation process 

## Vision: 

• By 2030, EFSA and partners will be equipped for the routine implementation of human health risk assessment to multiple chemicals, across EFSA’s domains of activity. Harmonised tools and consolidated data will be available for a structured and efficient assessment of both dietary and non-dietary exposure to multiple chemicals. Available methods will be fit-for- purpose and address requirements from the sectoral legislations. 

## Scope and objectives: 

• The main objective is to develop and implement a harmonised approach for the assessment of human health risks resulting from both dietary and non-dietary exposure to multiple chemicals. The proposed theme will therefore be divided in four work packages: methods development, tools harmonisation, data consolidation and implementation. 

• In a first instance, EFSA will screen the deliverable of previous projects to identify relevant methodological developments in this area. These methods will then be translated into practical and harmonised tools that can be applied across all domains of EFSA, and necessary input data will be consolidated into structured formats. In a second instance, EFSA will continue to monitor other ongoing projects and identify possible needs for further innovation and methodological development in both hazard and exposure assessment. 

• In order to ensure a steady and manageable progress, risk assessment to multiple chemicals will be implemented with a stepwise approach. EFSA will first prioritise the routine risk assessment of dietary exposure to multiple pesticides, with a subsequent integration of non- dietary exposure to pesticides. Methods to prioritise other chemicals will also be developed and, building on the experience gained in the area of pesticides, the scope of the implementation plan will be extended to other chemicals. 

• In view of increasing the outreach towards national competent authorities, EFSA will promote the implementation of the methods and tools developed and provide adequate training, where necessary. 

