content_image/937304.jpg content_image/937285.jpg content_image/937314.jpg content_image/937309.jpg
# c12) United States Patent Tamarkin et al. 

# (54) COMPOSITIONS WITH MODULATING AGENTS 

(71) Applicant: Foamix Pharmaceuticals Ltd., Rehovot (IL) 

(72) Inventors: Dov Tamarkin, Macabim (IL); Meir Eini, Ness Ziona (IL); Doron Friedman, Karmei Yosef (IL); Tai Berman, Rishon le Ziyyon (IL); David Schuz, Gimzu (IL) 

(73) Assignee: Foamix Pharmaceuticals Ltd., Rehovot (IL) 

( *) Notice: Subject to any disclaimer, the term ofthis patent is extended or adjusted under 35 U.S.C. 154(b) by O days. This patent is subject to a terminal dis› claimer. 

(21) Appl. No.: 14/045,528 

(22) Filed: Oct. 3, 2013 

## (65) Prior Publication Data 

US 2015/0017103 Al Jan. 15, 2015 

(63) Continuation of application No. 11/947,751, filed on Nov. 29, 2007, now Pat. No. 8,795,693, which is a continuation-in-part of application No. 10/835,505, filed on Apr. 28, 2004, now Pat. No. 7,820,145, and a continuation-in-part of application No. 11/430,599, filed on May 9, 2006, now Pat. No. 7,704,518. 

(60) Provisional application No. 60/530,015, filed on Dec. 16, 2003, provisional application No. 60/492,385, filed on Aug. 4, 2003, provisional application No. 60/784,793, filed on Mar. 21, 2006, provisional application No. 60/679,020, filed on May 9, 2005, provisional application No. 60/861,620, filed on Nov. 29, 2006. 

(51) Int. Cl. 

<img src='content_image/937304.jpg'>

(52) U.S. Cl. CPC ................. A61K 47112 (2013.01); A61K 91122 (2013.01); A61K 31/167 (2013.01); A61K 31/341 (2013.01); A61K 311375 (2013.01); A61K 311573 (2013.01); A61K 311593 (2013.01); A61K 47118 (2013.01); A61K 471183 (2013.01); A61K 47126 (2013.01); 

## Related U.S. Application Data 

<img src='content_image/937285.jpg'>

# (IO) Patent No.: US 9,101,662 B2 

# (45) Date of Patent: * Aug. 11, 2015 

(58) Field of Classification Search CPC ........................................................ A61K 9/12 See application file for complete search history. 

## (56) References Cited 

<img src='content_image/937314.jpg'>

U.S. Appl. No. 60/789,186, filed Apr. 4, 2006, Tarnarkin. 

U.S. Appl. No. 60/815,948, filed Jun. 23, 2006, Tarnarkin. 

U.S. Appl. No. 60/818,634, filed Jul. 5, 2006, Friedman. 

U.S. Appl. No. 60/843,140, filed Sep. 8, 2006, Tarnarkin. 

U.S. Appl. No. 61/248,144, filed Oct. 2, 2009, Tarnarkin. 

Primary Examiner - Robert A Wax 

Assistant Examiner - Melissa Mercier 

(74) Attorney, Agent, or Firm - Fish & Richardson P.C. 

## (57) ABSTRACT 

The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cos› metic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment admin› istering the waterless composition and foam. 

<img src='content_image/937309.jpg'>

US009101662B2 

A61K 47132 (2013.01); A61K 9/0014 (2013.01); A61K 9/0031 (2013.01); A61K 9/0034 (2013.01); A61K 9/0043 (2013.01); A61K 9/0046 (2013.01); A61K 9/0048 (2013.01); A61K 9/0056 (2013.01) 

## U.S. PATENT DOCUMENTS 

(Continued) 

## FOREIGN PATENT DOCUMENTS 

(Continued) 

## OTHER PUBLICATIONS 

(Continued) 

## 46 Claims, No Drawings 

