Kamaike et al., "Oligonucleotide Synthesis by the Use of a 2-(Levulinyloxymethyl)-5-nitrobenzoyl Group as the Novel Base› labile Protecting Group for the 5’Hydroxyl Groups ofRibonucleoside and 2’-Deoxyribonucleoside 3’- Phosphoramidites"; Tetrahedron Letters; 1997; pp. 6857-6860; vol. 38; No. 39. 

Katoaoka et al., "Ethyl(methyl)dioxirane as an Efficient Reagent for the Oxidation of Nucleoside Phosphites into Phosphates under Nonbasic Anhydrous Conditions"; Organic Letters; 2001; pp. 815- 818; vol. 3; No. 6. 

Kawahara et al., "Unprecedented Mild Acid-Catalyzed Desilylation of the 2’-O-tert-Butyldimethylsilyl Group from Chemically Synthe› sized Oligoribonucleotide Intermediates via Neighboring Group par› ticipation of the Internucleotidic Phosphate Residue"; Journal of the American Chemical Society; 1996; pp. 9461-9468; vol. 118; No. 40. Kumar et al., "Improvements in Oligodeoxyribonucleotide Synthe› sis: Methyl N,N-Dialkylphosphoramidite Dimer Units for Solid Sup› port Phosphite Methodogy"; Journal of Organic Chemistry; 1984; pp. 4905-4912; vol. 49. 

Lehmann et al., "Solid-phase synthesis of oligoribonucleotides using 9-fluorenylmethoxycarbonyl (Fmoc) for 5-40 -hydroxyl protection"; Nucleic Acids Research; 1989; pp. 2379-2390; vol. 17; No. 7. 

Lloyd et al., "Some observations relating to the use of l-aryl-4- alkoxypiperidin-4-yl groups for the protection of the 2’-hydroxy functions in the chemical synthesis of oligoribonucleotides"; Journal of Chemical Society Perkin Transactions l; 2000; pp. 165-176. 

Manoharan et al.; "Ally! Group as a Protecting Group for Internucleotide Phosphate and Thiophosphate Linkages in Oligoncleotide Synthesis: Facile Oxidation and Deprotection Con› ditions"; Organic Letters; 2000; pp. 243-246; vol. 2, No. 3. 

Matysiak et al., "Acetals as New 2’-O-Protecting Functions for the Synthesis of Oligoribonucleotides: Synthesis of Uridine Building Blocks and Evaluation of Their Relative Acid Stability"; Helvetica ChimicaActa; 1998; pp. 1545-1566; vol. 81. 

McBride et al., "An Investigation of Several Deoxynucleoside Phoshoramidites Useful for Synthesizing Deoxyolignucleotides", Tetrahedron Letters; 1983; pp. 245-248; vol. 24, No. 3. 

Micklefield; "Backbone Modification of Nucleic Acids: Synthesis, Structure and Therapeutic Applications"; Current Medicinal Chem› istry; 2001; pp. 1157-1179; vol. 8. 

Munch et al., "The (2-Cyano-1-Phenyl) Ethoxycarbonyl (CPEOC) Group-A New Protecting Group for Oligoribonucleotide Synthe› sis"; Nucleosides and Nucleotides; 1997; pp. 801-808; vol. 16; Nos. 5 and 6. 

Norman et al.; "The Protection of 2’-Hydroxy Functions in Oligoriboncleotide Synthesis"; Tetrahedron Letters; 1984; pp.3015- 3018; vol. 25; No. 28. 

Ohtsuka et al., "Studies on transfer ribonucleic acids and related compounds. XLV. Block condensation of ribooligonucleotides con› tammg 2’-O-tetrahydrofuranyl-5’-O-dimethoxytritylnucleosides"; Nucleic Acids Research; 1983; pp. 1325-1335; vol. 11; No. 5. 

Ono et al.; "The synthesis of blocked triplet-phosphoramidites and their use in mutagenesis"; Nucleic Acid Research; 1995; pp. 4677- 4682; vol. 23; No. 22. 

Palom et al., "An Acid-Labile Linker for Solid-Phase Oligoribonucleotide Synthesis Using Fmoc Group for 5’Hydroxyl Protection"; Tetrahedron Letters; 1993; pp. 2195-2198; vol. 34; No. 13. 

## OTHER PUBLICATIONS 

Rao et al.; "Use of the 1-(2-Fluorophenyl)-4-methoxypiperidin-4-yl (Fpmp) Protecting Group in the Solid-Phase Synthesis ofOligo- and Poly-ribonucleotides"; Journal of the Chemical Society-Perkin Transactions l; 1993; pp. 43-55. 

Reese et al., "4-Methoxytetrahydropyran-4-yl A Symmetrical Alter› native to the Tetrahydropyranyl Protecting Group"; Tetrahedron; 1970; pp. 1023-1030; vol. 26. 

Robles et al., "Solid-Phase synthesis of a nucleopeptide from the linking site of adenovirus-2 nucleoprotein, -Ser (p5’CATCAT)-Gly› Asp-. Convergent versus stepwise strategy" Nucleic Acids Research; 1995; pp. 4151-4161; vol. 23; No. 20. 

Sandstrom et al., "Chemical Synthesis of a Pentaribonucleoside Tetraphosphate Constituting the 3’-Acceptor Stem Sequence of E. colitRNAileUsing2’-O-(3-Methoxy-l,5-dicarbomethoxypentan-3- yl)-ribonucleoside Building Blocks. Application of a New Achiral and Acid-labile 2’-Hydroxyl Protecting Group in tRNA Synthesis"; Acta Chemica Scandinavica B; 1985; pp. 273-290; vol. 39. 

Scaringe et al., "Novel RNA Synthesis Method Using 5’-O-Silyl-2’› O-orthester Protecting Groups"; Journal of the American Chemical Society; 1998; pp. 11820-11821; vol. 120. 

Seio et al., "Synthesis of pentathymidylate using a 4-monomethoxytritylthio (MMTrS) group as a 5’-hydroxyl protect› ing group: toward oligonucleotide synthesis without acid treatment"; Tetrahedron Letters; 2001; pp. 8657-8660; vol. 42. 

Sekine et al., "Synthesis of Short Oligoribonucleotides Bearing a 3’› or 5’- Terminal Phosphate by use of 4, 4’,4"-Tris(4,5- dichlorophthalimido )trityl as a New 5’-Hydroxyl Protection Group", Journal of American Chemical Society; 1986; pp. 4581-4586; vol. 108. 

Sekine et al., "Proton-Block Strategy for the Synthesis of Oligodeoxynucleotides without Base Protection, Capping Reaction, and P-N Bond Cleavage Reaction"; Journal of Organic Chemistry; 2003; pp. 5478-5492; vol. 68. 

Seliger et al., "The P-Phenylazophenyloxycarbonyl Protecting Group: Selective Deblocking and Oligonucleotide Synthesis Avoid› ing Acid Steps"; Nucleosides & Nucleotides; 1985; pp. 153-155; vol. 4, No. 1 and 2. 

Sierzchala et al., "Solid-Phase Oligodeoxynucleotide Synthesis: A Two-Step Cycle Using Peroxy Anion Deprotection"; Journal of American Chemical Society; 2003; pp. 13427-13441; vol. 125. 

Sinha et al.; "beta-Cyanoethyl N, N-Dialkylamino/N› Morpholinomonochloro Phosphoamidites, New Phosphitylating Agents Facilitating Ease of Deprotection and Work-Up of Synthe› sized Oligonucleotides"; Tetrahedron Letters; 1983; pp. 5843-5846; vol. 24; No. 52. 

Song et al.; "A Short, Novel, and Cheaper Procedure for Oligonucleotide Synthesis Using Automated Solid Phase Synthe› sizer"; Nucleosides, Nucleotides & Nucleic Acids; 2003; pp. 629- 633; vol. 22; Nos. 5-8. 

Temsamani et al.; "Sequence identity of the n-1 product ofa synthetic oligonucleotide"; Nucleic Acids Research; 1995; pp. 1841-1844; vol. 23; No. 11. 

Tsukamoto et al.; "Strategies Useful for the Chemical Synthesis of Oligonucleotides and Related Compounds"; Frontiers in Organic Chemistry; 2005; pp. 3-38; vol. 1. 

* cited by examiner 

