content_image/923181.jpg
# (19) United States 

# (12) Patent Application Publication Hsu et al. 

# (54) TRANSDERMALAND TOPICAL ADMINISTRATION OF DRUGS USING BASIC PERMEATION ENHANCERS 

(76) Inventors: Tsung-Min Hsu, San Diego, CA (US); Nicole T. Gricenko, San Diego, CA (US); Alan T. J. Hickey, San Diego, CA (US); Eric C. Jacobson, San Diego, CA (US); Rose C. LoBello, San Diego, CA (US); Jane Ohara, San Diego, CA (US); Eric C. Luo, Plano, TX (US) 

Correspondence Address: REED INTELLECTUAL PROPERTY LAW GROUP 800 MENLO AVENUE, SUITE 210 MENLO PARK, CA 94025 (US) 

(21) Appl. No.: 10/863,432 

(22) Filed: Jun. 7, 2004 

(60) Continuation-in-part of application No. 10/176,952, filed on Jun. 21, 2002, now abandoned. 

Continuation-in-part of application No. 10/675,603, filed on Sep. 29, 2003, which is a division of appli› cation No. 10/176,265, filed on Jun. 19, 2002, now Pat. No. 6,673,363, and which is a continuation-in› part of application No. 10/175,769, filed on Jun. 19, 2002, now abandoned, and which is a continuation› in-part of application No. 10/175,721, filed on Jun. 

## Related U.S. Application Data 

<img src='content_image/923181.jpg'>

US 20050074487Al 

# (10) Pub. No.: US 2005/0074487 Al 

# (43) Pub. Date: Apr. 7, 2005 

19, 2002, now abandoned, and which is a continua› tion-in-part of application No. 10/175,682, filed on Jun. 19, 2002, and which is a continuation-in-part of application No. 10/176,264, filed on Jun. 19, 2002, and which is a continuation-in-part of application No. 10/175,681, filed on Jun. 19, 2002. 

Continuation-in-part of application No. 09/972,008, filed on Oct. 4, 2001, now Pat. No. 6,582,724, which is a continuation-in-part of application No. 09/738, 410, filed on Dec. 14, 2000, now Pat. No. 6,586,000, which is a continuation-in-part of application No. 09/569,889, filed on May 11, 2000, now abandoned, which is a continuation-in-part of application No. 09/465,098, filed on Dec. 16, 1999, now abandoned. Continuation-in-part of application No. 09/738,395, filed on Dec. 14, 2000, now Pat. No. 6,719,997, which is a continuation-in-part of application No. 09/607,892, filed on Jun. 30, 2000, now abandoned. 

(51) Int. Cl.7 ........................... A61L 15/16; A61K 33/00 

(52) U.S. Cl. ............................................ 424/448; 424/722 

## (57) ABSTRACT 

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described. 

## Publication Classification 

