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Concentration, pH, and Osmolality 

[0400] The aflibercept concentration (mg/mL), pH, and osmolality (mOSm) of the Block C formulations were evaluated at tO. Results are reported in Table 31 below. 

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Size Exclusion Chromatography 

[0401] The stability of the Block C formulations was evaluated by measuring the amount of non-degraded afliber› cept present in the formulation at time 0 (t0) and after being subjected to storage conditions. Size Exclusion Chromatog› raphy was conducted on the formulations and the percentage of protein present in the main peak (non-degraded afliber› cept) in each formulation is reported in Tables 32-35 below. 

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