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# c19) United States c12) Patent Application Publication 

# Ostrovsky et al. 

# (54) (lR,l’R)-ATRACURIUM SALTS SEPARATION PROCESS 

(75) Inventors: Elena Ostrovsky, Rishon Le-Zion (IL); OdedArad, Rehovot (IL) 

Correspondence Address: LEYDIG VOIT & MAYER, LTD TWO PRUDENTIAL PLAZA, SUITE 4900, 180 NORTH STETSON AVENUE CHICAGO, IL 60601-6731 (US) 

(73) Assignee: CHEMAGIS LTD., Bnei Brak (IL) 

(21) Appl. No.: 12/529,771 

(22) PCT Filed: Mar. 5, 2008 

(86) PCT No.: PCT /IL2008/000291 § 371 (c)(l), (2), ( 4) Date: Dec. 16, 2009 

<img src='content_image/946504.jpg'>

(60) Provisional application No. 60/908,088, filed on Mar. 26, 2007. 

(51) Int. Cl. C07D 401112 (2006.01) 

(52) U.S. Cl. ........................................................ 546/140 

## (57) ABSTRACT 

Provided is a method for separating cisatracurium from a mixture of atracurium isomers, which method includes elut› ing from a Reverse Phase (RP) stationary phase with a mobile phase in which the isomers are stable. The method of the present invention can be conveniently and inexpensively scaled up. 

US 20100087650Al 

# c10) Pub. No.: US 2010/0087650 Al 

# (43) Pub. Date: Apr. 8, 2010 

## Related U.S. Application Data 

## Publication Classification 

