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iv) Perform an analysis of the relevance and added value of the working areas that are listed in the theme paper as well as those additional ones that have been identified (see objective 3i, above) to achieve EFSA’s vision as defined in the theme paper (Annex 4); 

v) Explore opportunities for the use of artificial intelligence (AI) 13  approaches in the area of NAMs including data extraction and integration of information from different sources. The tenderer needs to be available to be interviewed by a contractor (still to be identified through a separate call for tenders) preparing the roadmap for action on artificial intelligence in evidence management in the risk assessment. 

## Objective 4: Identifying challenges and blockers 

i) Identify potential challenges and blockers focusing on critical elements for the consideration as “valid methods” and the integrating non-standardised NAM- based studies in the regulatory context to perform improved risk assessments based on mechanistic understanding; 

ii) Assess the impact of challenges and blockers (see objective 4.i, above) for EFSA’s vision as defined in the theme paper (Annex 4); 

iii) Explore feasible alternatives to overcome challenges and blockers (see objective 4.i, above). 

## Objective 5: Assessing cooperation/collaboration opportunities 

i) Identify opportunities and potential partners and evaluate means/tools (workshops, conferences, sharing databases etc) for pertinent cooperation/collaboration with potential partners outlined in the theme paper and any additional potential partner identified; 

ii) Perform an analysis of the added value and benefits of pertinent cooperation/collaboration opportunities (see objective 5.i, above), as well as possible challenges of the identified potential partnerships, and including any prioritisation considerations. Conduct a specific assessment of the OECD and ECVAM workplans for the next years and identify in those workplans the elements related to NAMs with specific interest for implementing EFSA’s vision (as outlined in the theme paper, Annex 4). Present a SWOT or equivalent analysis for supporting the prioritisation of cooperation/collaboration opportunities by EFSA. 

