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# c12) United States Patent Hong et al. 

# (54) LIPOSOMES USEFUL FOR DRUG DELIVERY 

(71) Applicant: Ipsen Biopharm Ltd., Wrexham (GB) 

(72) Inventors: Keelung Hong, San Francisco, CA (US); Daryl C. Drummond, Lincoln, MA (US); Dmitri Kirpotin, Revere, MA (US) 

(73) Assignee: IPSEN BIOPHARM LTD., Wrexham (GB) 

( *) Notice: Subject to any disclaimer, the term ofthis patent is extended or adjusted under 35 U.S.C. 154(b) by O days. This patent is subject to a terminal dis› claimer. 

(21) Appl. No.: 14/965,140 

(22) Filed: Dec. 10, 2015 

## (65) Prior Publication Data 

US 2016/0095817 Al Apr. 7, 2016 

(60) Continuation of application No. 14/632,422, filed on Feb. 26, 2015, which is a division of application No. 

(51) Int. Cl. 

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(52) U.S. Cl. CPC .......... A61K 911271 (2013.01); A61K 9/0019 (2013.01); A61K 91127 (2013.01); 

## Related U.S. Application Data 

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# (IO) Patent No.: US 9,724,303 B2 

# * Aug. 8, 2017 (45) Date of Patent: 

(58) Field of Classification Search None See application file for complete search history. 

## (56) References Cited 

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T-H Chou, S-C Chen, I-M Chu. "Effect of Composition on the Stability of Liposomal Irinotecan Prepared by a pH Gradient Method." Journal of Bioscience and Bioengineering, vol. 95 No. 4, 2003, pp. 405-408.* 

Primary Examiner - Isaac Shomer 

(74) Attorney, Agent, or Firm - Cynthia M. Bott; 

Christopher C. Forbes; Honigman Miller Schwartz and Cohn LLP 

## (57) ABSTRACT 

The present invention provides liposome compositions con› taining substituted ammonium and/or polyanion, and option› ally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention. 

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US009724303B2 

## U.S. PATENT DOCUMENTS 

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## FOREIGN PATENT DOCUMENTS 

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## OTHER PUBLICATIONS 

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## 20 Claims, 29 Drawing Sheets 

