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Histone deacetylases (HDAC) play a role in cancer cell growth by condensing the DNA and regulating gene expression critical to cell proliferation. Pivanex GLYPH<H23006> acts to inhibit HDACs in cancer cells, activating gene expression to stop cancer cell growth and induce cell differentiation, leading to cancer cell death. 

Titan recently completed a Phase II study of Pivanex in non-small cell lung cancer with encouraging results. In this study, Pivanex showed preliminary therapeutic activity and was very well tolerated, without the severe side effects seen with many current cancer treatments. 

Pivanex 

Open, active DNA leads to gene expression 

## Targeting a Key Enzyme in Cancer Growth 

Condensed, inactive DNA 

HDAC enzyme 

Pivanex binds to and inhibits HDACs 

## Pivanex GLYPH<H23006> 

Tumor cell death 

