content_image/924999.jpg content_image/925001.jpg
wherein: 

<img src='content_image/924999.jpg'>

substituted heterocycle is heterocycle as defined above having one or more substituents independently selected from halogen, C$_{1}$-C$_{4 }$ alkoxy, C$_{1}$-C$_{4 }$ alkyl, fluorinated C$_{1}$-C$_{4 }$ alkoxy, fluorinated C$_{1 }$-C$_{4 }$ alkyl, -S-CH$_{3}$ , -N(CH$_{3}$ ) 2 , thiazolyl, and oxazolyl; and 

Xis O or S; 

R 4 is 

<img src='content_image/925001.jpg'>

9. The composition according to claim 8, wherein the complex comprises a compound of Formula (I) or a phar› maceutically acceptable salt thereof, wherein: 

R 2 and R 3 are each independently hydrogen or methyl; each L is independently hydrogen, chlorine, or fluorine; each Y is independently hydrogen, chlorine, or fluorine; and 

each of the substituents on substituted heterocycle is independently chlorine, fluorine, methoxy, ethoxy, -OCF$_{3}$ , -OCHF$_{2}$ , methyl, ethyl, n-propyl, -S-CH$_{3}$ , -N(CH$_{3}$ ) 2 , and thiazolyl. 

10. The composition according to claim 1, wherein the complex comprises a compound selected from the group consisting of: 

( aR,yS,2S)-N-( (3S,4S)-3,4-dihydro-3-hydroxy-2H-1- benzopyran-4-yl)-4-(1-furo[3,2-c ]pyridin-2-yl-1-meth› ylethyl)-y-hydroxy-a-(phenylmethyl)-2-[[(2,2,2-trif› luoroethyl)amino ]carbonyl]-1-piperazinepentanamide; 

( aR,yS ,2S)-N-( (3S,4S)-3,4-dihydro-3-hydroxy-2H-1- benzopyran-4-y l)-y-hydroxy-4-[ ( 5-pheny 1-2-furanyl› )methy l ]-a-( 4-pyridinylmethyl)-2-[[(2,2,2-trifluoroet› hyl)amino ]-carbonyl]-1-piperazinepentanamide; 

( aR,yS,2S)-N-( (3S,4S)-3,4-dihydro-3-hydroxy-2H-1- benzopyran-4-yl)-y-hydroxy-4-[1-methyl-1-(1-phenyl› lH-pyrazol-3-y l)ethy 1 ]-a-( 3-pyridiny lmethy 1)-2-[[ (2, 2,2-trifluoroethyl)amino ]carbonyl ]-1- piperazinepentanamide; 

( aR,yS,2S)-N-( (3S,4S)-3,4-dihydro-3-hydroxy-2H-1- benzopyran-4-yl)-y-hydroxy-a-(phenylmethyl)-4-[[ 5- (2-pyridinyl)-2-furanyl ]me thy 1 ]-2-[[ (2,2,2-trifluoroet› hy l)-amino ]carbonyl]-1-piperazinepentanamide; 

( aR, yS,2S)-4-[[ 5-( 5-chloro-2-pyridiny 1)-2-furany 1 ]me› thyl]-N-( (3S,4S)-3,4-dihydro-3-hydroxy-2H-1-ben› zopyran-4-yl)-y-hydroxy-a-(phenylmethyl)-2-[[(2,2,2- trifluoroethyl)amino ]carbonyl ]-1- piperazinepentanamide; 

( aR,yS,2S)-N-(3S,4S)-3,4-dihydro-3-hydroxy-2H-1-ben› zopyran-4-yl]-y-hydroxy-4-[1-methyl-1-[ 5-(3-pyridi› ny 1)-2-oxazoly 1 ]ethyl ]-a-(pheny lmethy 1)-2-[[ (2,2,2- trifluoroethy l)amino ]carbonyl ]-1- piperazinepentanamide; 

( aR,yS,2S)-N-(3S,4S)-3,4-dihydro-3-hydroxy-2H-1-ben› zopyran-4-y 1 ]-y-hydroxy-4-[ 1-[ 5-( 5-methoxy-3-pyridi› ny 1)-2-oxazoly l ]-l-methylethyl]-a-(phenylmethyl)-2- [[ (2,2,2-trifluoroethyl)amino ]carbonyl]-1- piperazinepentanamide; 

( aR,yS,2S)-N-[ (3S,4S)-3,4-dihydro-3-hydroxy-2H-1- benzopyran-4-y 1 ]-y-hydroxy-4-[ 1-[ 5-( 5-fluoro-3-py› ridiny 1)-2-oxazoly l ]-l-methylethyl]-a-(phenylm› ethyl)-2-[[ (2,2,2-trifluoroethyl)amino ]carbonyl]-1- piperazinepentanamide; 

( aR,yS,2S)-N-[ (3S,4S)-3,4-dihydro-3-hydroxy-2H-1- benzopyran-4-yl]-y-hydroxy-4-[1-[1-( 5-fluoro-3-py› ridinyl)-lH-pyrazol-3-yl ]- l-methylethyl]-a-(phenylm› ethyl)-2-[[ (2,2,2-trifluoroethyl)amino ]carbonyl]-1- piperazinepentanamide; 

( aS,yS,2S)-4-[1-[ 5-( 4-chlorophenyl)-2-oxazolyl]-1-me› thylethyl ]-N-[ (3S,4S)-3,4-dihydro-3-hydroxy-2H-1- benzopyran-4-y 1 ]-a-( furo[2,3-c ]pyridin-2-y lmethy l)-y› hydroxy-2-[[ (2,2,2-trifluoroethy l)amino ]carbonyl ]-1- piperazinepentanamide; 

