56. The foamable waterless composition of claim 55 fur› ther comprising one or more agents that additionally are capable of impeding said destabilization and or are capable of stabilizing the active agent primarily by modulating or adjust› ing the artificial pH of the carrier such that the modulating agent is capable of producing in the carrier an artificial pH or an artificial pH buffering effect at about a pH or pH range in which the stability of at least one active agent is improved when compared to its stability in the carrier without the modulating agent and or by impeding ionization and or by impeding oxidation. 

57. The foamable waterless composition of claim 55 wherein the modulating agent is a chelating agent. ’ 

58. The foamable waterless composition of claim 57 wherein the chelating agent is sufficiently soluble or func~ tional in the polar solvent to enable it to "mop up" or "lock" metal ions. 

59. The foamable waterless composition of claim 57 wherein the chelating agent is selected from the group con~ sisting of ethylenediaminetetraacetic acid ("EDTA") and salts thereof, disodium EDTA, tetrasodium EDTA, calcium disodium EDTA; diethylenetriaminepentaacetic acid ("DTPA") and salts thereof; hydroxyethlethylenediamin› etriacetic acid ("HEDTA") and salts thereof; and nitrilotri› ace~ic a~id ("NTA’’) and salts thereof; acetyl trihexyl citrate, ammotnmethylene phosphonic acid, beta-alanine diacetic acid, bismuth citrate, calcium disodium edta citric acid cyclohexanediamine tetraacetic acid, diammocium citrate’ dibutyl oxalate, diethyl oxalate, diisobutyl oxalate, diisopro~ pyl oxalate, dilithium oxalate, dimethyl oxalate, dipotassium edta, dipotassium oxalate, dipropyl oxalate, disodium edta, disodium edta-copper, disodium pyrophosphate, edta, etidronic acid, hedta, methyl cyclodextrin, oxalic acid, pen› tapotassium, triphosphate, pentasodium aminotrimethylene phosphonate, pentasodium pentetate, pentasodium triphos- phate, pentetic acid, phytic acid, potassium citrate, sodium citr~te, sodium dihydroxyethylglycinate, sodium gluceptate, sodmm gluconate, sodium hexametaphosphate, sodium metaphosphate, sodiummetasilicate, sodium oxalate, sodium trimetaphosphate, tea-edta, tetrahydroxypropyl ethylenedi- amine, tetrapotassium etidronate, tetrapotassium pyrophos› phate, tetrasodium edta, tetrasodium etidronate tetrasodium pyrophosphate, tripotassium edta, trisodium edta, trisodium hedta, trisodium nta, trisodium phosphate, malic acid fumaric acid, maltol, succimer, penicillamine, dimercaprol: and desferrioxamine mesilate. 

60. A foamable waterless carrier for use with a therapeuti› cally effective concentration of one or more active agents comprising: 

i. about 25% to about 98% of at least polar solvent selected from the group consisting of (1) a polyol; and (2) a polyethylene glycol; 0% to about 75% of a secondary polar solvent; 

ii. a modulating agent; 

iii. about 0.01 % to about 5% by weight of at least one polymeric agent; 

iv. a surface active agent; 

v. a foam adjuvant selected from the group consisting of a fatty alcohol having 15 or more carbons in its carbon 

chain, a fatty acid having 16 or more carbons in its carbon chain and mixtures of any two or more thereof› and ’ 

vi. a liquefied or compressed gas propellant at a concen› tration of about 3% to about 25% by weight of the foamable waterless carrier, wherein the gas propellant is essentially free of chlorofluorocarbons 

wherein at least one active agent if present is susceptible, to one or more of reaction, breakdown, ionization or oxi› dation; 

wherein the modulating agent comprises one or more agents that are capable of impeding said destabilization and or are capable of stabilizing the active agent prima› rily by modulating or adjusting the artificial pH of the carrier such that the modulating agent is capable of producing in the waterless carrier an artificial pH or an artificial pH buffering effect at about a pH or pH range in which the stability of at least one active agent is improved when compared to its stability in the carrier without the modulating agent and or by chelating a metal ion such that the modulating agent is capable of reducing in the waterless carrier the availability of metal ions so the stability of at least one active agent is improved when compared to its stability in the carrier without the modu› lating agent; 

wherein the foamable waterless carrier is shakable or flow› able; and 

wherein the foamable waterless carrier is stored in an aero› sol container and upon release expands to form a break› able foam that collapses upon application of shear force; and 

wherein the polymeric agent is selected from the group consisting of a locust bean gum, sodium alginate, sodium caseinate, an egg albumin, a gelatin agar, a car› rageenin gum, a xanthan gum, a quince seed extract, a tragacanth gum, a guar gum, a cationic guar, a hydrox› yp~opyl guar gum, a starch, an amine-bearing polymer, a ch1tosan, an alginic acid, a hyaluronic acid, a chemically modified starch, a carboxyvinyl polymer, a polyvinyl al~ohol, a polyacrylic acid polymer, a polymethacrylic acid polymer, a polyvinyl acetate, a polyvinyl chloride polymer, a polyvinylidene chloride polymer, a methyl› cellulose, a hydroxypropyl cellulose, a hydroxypropyl methylcellulose, a hydroxyethyl cellulose, a methylhy› droxyethylcellulose, a hydroxy ethyl carboxymethyl cel› lulose, a carboxymethyl cellulose, a cationic cellulose, a PEG 1000, a PEG 4000, a PEG 6000, a PEG 8000 and a carbomer. 

61. The waterless composition of claim 4, wherein the concentration of the polymeric agent is selected such that the viscosity of the composition is less than 12,000 CPs, or less than 10,000 CPs. 

62. The waterless composition of claim 1, wherein the modulating agent is an acid. 

63. The waterless composition of claim 62, wherein the acid is a fatty acid selected from the group consisting of stearic acid, !auric acid, myristic acid, valproic acid, and mixtures of any two or more thereof. 

* * * * * 

