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# c19) United States c12) Patent Application Publication 

# HSU et al. 

# (54) TRANSDERMALAND TOPICAL ADMINISTRATION OF VITAMINS USING BASIC PERMEATION ENHANCERS 

(75) Inventors: Tsung-Min HSU, San Diego, CA (US); Nicole T. GRICENKO, San Diego, CA (US); Alan T.J. HICKEY, San Diego, CA (US); Eric C. JACOBSON, San Diego, CA (US); Rose C. LOBELLO, San Diego, CA (US); Jane OBARA, San Diego, CA (US) 

(73) Assignee: TECHNOLOGY RECOVERY SYSTEMS, LLC, MINNEAPOLIS, MN (US) 

(21) Appl. No.: 13/468,821 

(22) Filed: May 10, 2012 

(60) Continuation of application No. 12/343,000, filed on Dec. 23, 2008, which is a continuation of application No. 10/860,887, filed on Jun. 3, 2004, now abandoned, which is a divisionofapplicationNo. 10/177,436, filed on Jun. 20, 2002, now abandoned, which is a continu- 

## Related U.S. Application Data 

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(51) Int. Cl. 

(52) U.S. Cl. ......................................... 604/307; 604/304 

## (57) ABSTRACT 

Methods are provided for enhancing the permeability of skin or mucosa! tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the organic base. Compositions and transdermal systems are also described. 

US 20120220962Al 

# c10) Pub. No.: US 2012/0220962 Al 

# (43) Pub. Date: Aug. 30, 2012 

ation-in-part of application No. 09/972,008, filed on Oct. 4, 2001, now Pat. No. 6,582,724, which is a con› tinuation-in-part of application No. 09/738,410, filed on Dec. 14, 2000, now Pat. No. 6,586,000, which is a continuation-in-part of application No. 09/738,395, filed on Dec. 14, 2000, now Pat. No. 6,719,997, which is a continuation-in-part of application No. 09/607, 982, filed on Jun. 30, 2000, now abandoned, which is a continuation-in-part of application No. 09/596,889, filed on Jun. 19, 2000, now Pat. No. 6,455,830, which is a continuation-in-part of application No. 09/465, 098, filed on Dec. 16, 1999, now abandoned. 

## Publication Classification 

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