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# c12) United States Patent Krogh et al. 

# (54) SYSTEM AND METHOD OF DELICATE MEMBRANE CONDENSED PHASE MEMBRANE INTRODUCTION MASS SPECTROMETRY (CP-MIMS) 

(71) Applicants:Erik Krogh, Nanaimo (CA); Christopher Gill, Lantzville (CA) 

(72) Inventors: Erik Krogh, Nanaimo (CA); Christopher Gill, Lantzville (CA) 

( *) Notice: Subject to any disclaimer, the term ofthis patent is extended or adjusted under 35 U.S.C. 154(b) by O days. 

(21) Appl. No.: 14/924,660 

(22) Filed: Oct. 27, 2015 

## (65) Prior Publication Data 

US 2016/0056030 Al Feb. 25, 2016 

(63) Continuation-in-part of application No. PCT/IB2014/061064, filed on Apr. 28, 2014. 

(60) Provisional application No. 61/827,936, filed on May 28, 2013. 

(51) Int. Cl. 

<img src='content_image/936824.jpg'>

(52) U.S. Cl. CPC ...... H0JJ 4910436 (2013.01); H0JJ 4910031 (2013.01) 

( 58) Field of Classification Search USPC ......................................... 250/281, 282, 288 See application file for complete search history. 

## Related U.S. Application Data 

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<img src='content_image/936794.jpg'>

# (IO) Patent No.: US 9,583,325 B2 

# (45) Date of Patent: Feb.28,2017 

## (56) References Cited 

<img src='content_image/936823.jpg'>

WIPO, Canadian International Searching Authority, International Search Report mailed Aug. 18, 2014, International Patent Applica› tion No. PCT/IB2014/061064, 4 Pages. 

Primary Examiner - Nicole Ippolito 

(74) Attorney, Agent, or Firm - Baumgartner Patent Law; Marc Baumgartner 

## (57) ABSTRACT 

Systems and methods for analyzing a sample comprising an analyte selected from a volatile organic compound, a semi› volatile organic compound, a non-volatile organic com› pound, a polar organic compound and a halogenated non› volatile organic compound are provided. The systems comprises an ionization source, a flow cell or an immersion probe with a delicate membrane, the flow cell or immersion probe for accepting the sample, and the delicate membrane interface in fluid communication with the ionization source and a mass spectrometer. The flow cell system further comprises a simultaneously matched pumping in and out delivery (SMPIOD) system for delivering an acceptor phase comprising the analyte from the delicate membrane interface to the mass spectrometer at a constant acceptor flow pressure and a constant acceptor flow rate. 

US009583325B2 

## U.S. PATENT DOCUMENTS 

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## OTHER PUBLICATIONS 

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## 21 Claims, 23 Drawing Sheets 

