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[0238] In some embodiments, the formulation can include aflibercept (e.g., at any of the final concentrations described herein); about 0.5% w/v to about 6% w/v (e.g., about 1.0% w/v to about 6% w/v, about 2.0% w/v to about 6% w/v, about 3.0% w/v to about 6.0% w/v, about 4.0% w/v to about 6.0% w/v, about 5.0% w/v to about 6.0% w/v) of a sugar (e.g., sucrose); about 1 mM to about 60 mM (e.g., about 1 mM to about 50 mM, about 1 mM to about 40 mM, about 1 mM to about 30 mM, about 1 mM to about 20 mM, about 1 mM to about 10 mM, about 5 mM to about 60 mM, about 5 mM to about 50 mM, about 5 mM to about 40 mM, about 5 mM to about 30 mM, about 5 mM to about 20 mM, about 5 mM to about 10 mM, about 10 mM to about 60 mM, about 10 mM to about 50 mM, about 10 mM to about 40 mM, about 10 mM to about 30 mM, about 10 mM to about 20 mM, about 20 mM to about 60 mM, about 20 mM to about 50 mM, about 20 mM to about 40 mM, about 20 mM to about 30 mM, about 30 mM to about 60 mM, about 30 mM to about 50 mM, about 30 mM to about 40 mM, about 40 mM to about 60 mM, about 40 mM to about 50 mM, or about 50 mM to about 60 mM) of a salt ( e.g., NaCl); about 0.01 % w/v to about 0.1% w/v (e.g., about 0.01% w/v to about 0.05% w/v) of a stabilizer (e.g., any of the stabilizers described herein, e.g., any of the polysorbates described herein); having a pH of about 5.5 to about 6.2 (e.g., about 6.0), and is free of buffer. 

[0239] In some embodiments, the formulation can include aflibercept (e.g., at any of the final concentrations described herein); about 0.5% w/v to about 6% w/v (e.g., about 1.0% w/v to about 6% w/v, about 2.0% w/v to about 6% w/v, about 3.0% w/v to about 6.0% w/v, about 4.0% w/v to about 6.0% w/v, about 5.0% w/v to about 6.0% w/v) of a sugar (e.g., sucrose); about 0.01% w/v to about 0.1% w/v (e.g., about 0.01 % w/v to about 0.05% w/v) of a stabilizer ( e.g., any of the stabilizers described herein, e.g., any of the polysorbates described herein); having a pH of about 5.5 to about 6.2 ( e.g., about 6.0), and is free of buffer. 

[0240] In some embodiments, the formulation can include aflibercept (e.g., at any of the final concentrations described herein); about 0.5% w/v to about 6% w/v (e.g., about 1.0% w/v to about 6% w/v, about 2.0% w/v to about 6% w/v, about 3.0% w/v to about 6.0% w/v, about 4.0% w/v to about 6.0% w/v, about 5.0% w/v to about 6.0% w/v) of a sugar (e.g., sucrose); about 0.1 mMto about 10 mM (e.g., about 0.1 mM to about 8 mM, about 0.1 mM to about 6 mM, about 0.1 mM to about 4 mM, about 0.1 mM to about 2 mM, about 0.1 mM 

to about 1 mM, about 0.5 mM to about 10 mM, about 0.5 mM to about 8 mM, about 0.5 mM to about 6 mM, about 0.5 mM to about 4 mM, about 0.5 mM to about 2 mM, about 0.5 mM to about 1 mM, about 1 mM to about 10 mM, about 1 mM to about 8 mM, about 1 mM to about 6 mM, about 1 mM to about 4 mM, about 1 mM to about 2 mM, about 2 mM to about 10 mM, about 2 mM to about 8 mM, about 2 mM to about 6 mM, about 2 mM to about 4 mM, about 4 mM to about 10 mM, about 4 mM to about 8 mM, about 4 mM to about 6 mM, about 6 mM to about 10 mM, about 6 mM to about 8 mM, or about 8 mM to about 10 mM) about a buffer (e.g., any of the buffers described herein, e.g., histidine or imidazole buffer); about 1 mM to about 60 mM ( e.g., about 1 mM to about 50 mM, about 1 mM to about 40 mM, about 1 mM to about 30 mM, about 1 mM to about 20 mM, about 1 mM to about 10 mM, about 5 mM to about 60 mM, about 5 mM to about 50 mM, about 5 mM to about 40 mM, about 5 mM to about 30 mM, about 5 mM to about 20 mM, about 5 mM to about 10 mM, about 10 mM to about 60 mM, about 10 mM to about 50 mM, about 10 mM to about 40 mM, about 10 mM to about 30 mM, about 10 mM to about 20 mM, about 20 mM to about 60 mM, about 20 mM to about 50 mM, about 20 mM to about 40 mM, about 20 mM to about 30 mM, about 30 mM to about 60 mM, about 30 mM to about 50 mM, about 30 mM to about 40 mM, about 40 mM to about 60 mM, about 40 mM to about 50 mM, or about 50 mM to about 60 mM) of a salt (e.g., NaCl); about 0.01% w/v to about 0.1% w/v (e.g., about 0.01 % w/v to about 0.05% w/v) of a stabilizer ( e.g., any of the stabilizers described herein, e.g., any of the polysorbates described herein); having a pH of about 5.5 to about 6.2 (e.g., about 6.0). 

[0241] In some embodiments, the formulation can include aflibercept (e.g., at any of the final concentrations described herein); about 0.5% w/v to about 6% w/v (e.g., about 1.0% w/v to about 6% w/v, about 2.0% w/v to about 6% w/v, about 3.0% w/v to about 6.0% w/v, about 4.0% w/v to about 6.0% w/v, about 5.0% w/v to about 6.0% w/v) of a sugar (e.g., sucrose); and is free of both a buffer and an organic co-solvent. 

[0242] In some embodiments, the formulation can include aflibercept (e.g., at any of the final concentrations described herein); about 0.5% w/v to about 6% w/v (e.g., about 1.0% w/v to about 6% w/v, about 2.0% w/v to about 6% w/v, about 3.0% w/v to about 6.0% w/v, about 4.0% w/v to about 6.0% w/v, about 5.0% w/v to about 6.0% w/v) of a sugar (e.g., 

