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Discussion 

[0432] The aflibercept formulations of Block F are physi› cally and chemically stable. 

[0433] This example describes experiments to evaluate aflibercept formulations with various excipient combina› tions (Block G). Formulations in Block G include those that are free of a buffer; free of an organic co-solvent; include a sugar other than sucrose, include a polyol; include a surfac› tant other than polysorbate 20 (e.g. in buffer-free formula› tions); include CaC1$_{2 }$ as a stabilizer; and have a high con› centration of aflibercept. Table 86, below, shows an exemplary set of such formulations. 

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## Example 8-Aflibercept Formulations 

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Concentration, pH, and Osmolality 

[0434] The aflibercept concentration (mg/mL), pH, and osmolality (mOSm) of the Block G formulations were evaluated at tO. Results are reported in Table 87 below. 

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