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[0411] All of these formulations exhibit monomer con› tents near 99% at TO, as was seen with other blocks. 

[0412] After one week at 40° C., the monomer content decreased to 97-98%, similar to what was observed for previous blocks. No fragmentation is noted and the losses are solely due to aggregation. At 25° C. storage there is only slight changes from the initial levels, suggesting that these types of excipients (amino acids, salts) are good stabilizers for aflibercept. For samples stored at 5° C. for four weeks, little degradation is seen as well. 

Micro-Flow Imaging 

[0413] The stability of the Block D formulations was evaluated by measuring the particles present in the formu› lation after being subjected to storage conditions. These samples were shipped frozen for MFI analysis and seem to have survived the shipping without any significant damage. Results are reported in Tables 50-53 below. 

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Note: 

(l)Need Time stamp, 90%- insufficent sample caused bottom right screen schlieren lines due to illumination error (2)Need Time stamp, 80%- insufficent sample caused bottom right screen schlieren lines 

due to illumination error 

