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$^{1}$plasma deposited thin film PDMS on microporous polypropylene, neoMecs Inc. (O.D. = 0.264; I.D. = 0.263) = = 

$^{2}$MedArray Inc (O.D. 0.24 mm; l.D. 0.17 mm) 

$^{3}$Silastic Dow-Corning (O.D. = 0.64 mm; I.D. = 0.30 mm) 

What is claimed is: 

1. A system for analyzing a sample comprising an analyte, the system comprising: 

an acceptor phase supply comprising an acceptor phase; 

an ionization source; 

a mass spectrometer; and 

a membrane interface device, the device compnsmg a membrane interface in fluid communication with an acceptor phase carrier, the membrane interface config› ured for bathing in the sample, under ambient pressure, the acceptor phase carrier in fluid communication with the acceptor phase supply, the ionization source and the mass spectrometer. 

2. The system of claim 1, wherein the membrane interface is a hollow fibre membrane (HFM) comprising polydimeth› ylsiloxane, ofno more than about 225 microns in thickness. 

3. The system of claim 2, wherein the membrane is a thin 55 membrane. 

4. The system of claim 2, wherein the membrane is a supported liquid membrane. 

5. The system of claim 2, wherein the probe is a J probe. 

6. The system of claim 2, wherein the probe is a miniature 60 coaxial probe. 

7. The system of claim 6, further comprising an autosam› pler. 

8. The membrane interface device of claim 6, wherein the miniature coaxial probe is an immersion probe, the probe comprising a membrane interface coaxial with-an acceptor phase delivery capillary and for fluid communication with 

the acceptor phase, the membrane interface configured for bathing in the sample, under ambient pressure, the acceptor phase delivery capillary in fluid communication with the acceptor phase supply, the ionization source and the mass spectrometer. 

9. The system of claim 1, further comprising a mixer for mixing the sample. 

10. An immersion probe for use with an ionization source and a mass spectrometer, the immersion probe comprising a membrane interface coaxial with an acceptor phase delivery capillary and for fluid communication with an acceptor phase, the membrane interface configured for bathing in the sample, under ambient pressure, the acceptor phase delivery capillary for fluid communication with acceptor phase sup› ply, the ionization source and the mass spectrometer. 

11. The probe of claim 10, wherein the membrane inter› face is a hollow fibre membrane (HFM) comprising poly- dimethylsiloxane, of about 0.5 microns to about 225 microns in thickness. 

12. The probe of claim 11, wherein the HFM is a composite PDMS micro-porous polypropylene HFM, a thin PDMS HFM or a supported liquid membrane HFM. 

13. A method of quantifying and measuring a trace level analyte in a sample, the sample being between about 1.0 µL to about 1 mL, the method comprising: 

exposing a membrane interface device to a sample, such that the membrane interface device is bathed in the sample; 

moving the sample over the membrane interface device; 

delivering an acceptor phase to the membrane interface device via an acceptor phase carrier; 

delivering the analyte to an ionization source and to a mass spectrometer; and obtaining an output, thereby quantifying and measuring the trace level analyte. 

14. The method of claim 13, wherein the measuring is direct. 

15. The method of claim 14, wherein the sample is a biological sample or an environmental sample. 

16. The method of claim 15, further comprising rapid prescreening the sample and providing the sample for fur› ther analyzing. 

17. The method of claim 15, wherein the measuring and quantifying provides direct, in vivo or in situ monitoring of the biological or the environmental sample. 

