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# c12) United States Patent Hong et al. 

# (54) LIPOSOMES USEFUL FOR DRUG DELIVERY 

(71) Applicant: Ipsen Biopharm Ltd., Wrexham (GB) 

(72) Inventors: Keelung Hong, San Francisco, CA (US); Daryl C. Drummond, Lincoln, MA (US); Dmitri Kirpotin, Revere, MA (US) 

(73) Assignee: IPSEN BIOPHARM LTD., Wrexham (GB) 

( *) Notice: Subject to any disclaimer, the term ofthis patent is extended or adjusted under 35 U.S.C. 154(b) by O days. This patent is subject to a terminal dis› claimer. 

(21) Appl. No.: 14/632,422 

(22) Filed: Feb. 26, 2015 

## (65) Prior Publication Data 

US 2015/0182460 Al Jul. 2, 2015 

(63) Continuation of application No. 14/175,365, filed on Feb. 7, 2014, now Pat. No. 8,992,970, which is a 

(51) Int. Cl. 

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(52) U.S. Cl. CPC ........ A61K 3114745 (2013.01); A61K 9/0019 (2013.01); A61K 91127 (2013.01); 

## Related U.S. Application Data 

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# (IO) Patent No.: US 9,717,723 B2 

# (45) Date of Patent: * Aug. 1, 2017 

(58) Field of Classification Search None See application file for complete search history. 

## (56) References Cited 

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T-H Chou, S-C Shen, I-M Chu. "Effect of Composition on the Stability of Liposomal Irinotecan Prepared by a pH Gradient Method." Journal of Bioscience and Bioengineering, vol. 95 No. 4, 2003, pp. 405-408.* 

Primary Examiner - Isaac Shomer 

(74) Attorney, Agent, or Firm - Cynthia M. Bott; Christopher C. Forbes; Honigman Miller Schwartz and Cohn LLP 

## (57) ABSTRACT 

The present invention provides liposome compositions con› taining substituted ammonium and/or polyanion, and option› ally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention. 

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US009717723B2 

## U.S. PATENT DOCUMENTS 

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## FOREIGN PATENT DOCUMENTS 

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## OTHER PUBLICATIONS 

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## 19 Claims, 29 Drawing Sheets 

