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# c12) United States Patent 

# Tamarkin et al. 

# (54) COMPOSITIONS WITH MODULATING AGENTS 

(75) Inventors: Dov Tamarkin, Maccabim (IL); Meir Eini, Ness Ziona (IL); Doron Friedman, Karmei Yosef (IL); Tai Berman, Rishon LeZiyyon (IL); David Schuz, Moshav Gimzu (IL) 

(73) Assignee: Foamix Ltd., Rehovot (IL) 

( *) Notice: Subject to any disclaimer, the term ofthis patent is extended or adjusted under 35 U.S.C. 154(b) by 1051 days. 

(21) Appl. No.: 11/947,751 

(22) Filed: Nov. 29, 2007 

## (65) Prior Publication Data 

US 2008/0206159 Al Aug. 28, 2008 

(63) Continuation-in-part of application No. 10/835,505, filed on Apr. 28, 2004, now Pat. No. 7,820,145, and a continuation-in-part of application No. 11/430,599, filed on May 9, 2006, now Pat. No. 7,704,518. 

(60) Provisional application No. 60/492,385, filed on Aug. 4, 2003, provisional application No. 60/530,015, filed on Dec. 16, 2003, provisional application No. 60/679,020, filed on May 9, 2005, provisional application No. 60/784,793, filed on Mar. 21, 2006, provisional application No. 60/861,620, filed on Nov. 29, 2006. 

(51) Int. Cl. 

<img src='content_image/929839.jpg'>

(52) U.S. Cl. CPC ................. A61K 31156 (2013.01); A61K 91122 (2013.01) USPC . ... ... ... .. ... ... ... ... ... .. ... ... ... ... ... .. ... ... ... ... 424/401 

(58) Field of Classification Search None See application file for complete search history. 

## (56) References Cited 

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## Related U.S. Application Data 

## U.S. PATENT DOCUMENTS 

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# (IO) Patent No.: US 8,795,693 B2 

# (45) Date of Patent: Aug. 5, 2014 

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## FOREIGN PATENT DOCUMENTS 

<img src='content_image/929841.jpg'>

Alcohol SDA 40B.http://www.pharmco-prod.com/pages/MSDS/ SDA_ 40B_200.pdf Accessed Dec. 9, 2008, 2 pages. 

Ambrose, Ursual et al., "In Vitro Studies of Water Activity and Bacterial Growth Inhibition of Sucrose-Polyethylene Glycol 400- Hydrogen Peroxide and Xylose-Polyethylene Glycol 400-Hydrogen Peroxide Pastes Used to Treat Infected Wounds," Antimicrobial Agents and Chemotherapy, vol. 35, No. 9, pp. 1799-1803, 1991. 

Arisan, http://www.arisankimya.com/kozmetik.htrn Accessed Dec. 10, 2008, 8 pages. 

Barry, B.W. et al, Comparative bio-availability and activity of pro› prietary topical corticosteroid preparations: vasoconstrictor assays on thirty-one ointments, British Journal of Dermatology, 93, 563- 571, 1975. 

Primary Examiner - Anand Desai 

Assistant Examiner - Melissa Mercier 

(74) Attorney, Agent, or Firm - Fish & Richardson P.C. 

## (57) ABSTRACT 

The present invention relates to a waterless composition and foam as a vehicle in which an active pharmaceutical or cos› metic agent, when added is stable or stabilized by or its destabilization is impeded by the presence of a modulating agent. The pharmaceutical or cosmetic composition and foam, includes: a waterless solvent, a modulating agent and one or more active pharmaceutical or cosmetic agents. The present invention also relates to a method of treatment admin› istering the waterless composition and foam. 

US008795693B2 

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## OTHER PUBLICATIONS 

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## 63 Claims, No Drawings 

