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[0300] Synthesis of Intermediate P 

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[0301] A mixture of 16.3 g of Intermediate 0, 0.3 g of p-toluenesulfonic acid monohydrate, and 163 g of methanol was stirred and aged at room temperature for 65 hours and at 50° C. for 24 hours. The completion of reaction was confirmed by $^{19}$F-NMR spectroscopy, whereupon methyl tert-butyl ether was added to the solution. After stirring, a solid was collected by filtration. The solid was washed with methyl tert-butyl ether and dried in vacuum, obtaining 13.3 g of Intermediate P (yield 91 % ). 

[0302] Intermediate P was analyzed by spectroscopy. The NMR spectra, $^{1}$H- and $^{19}$F-NMR in DMSO-d$_{6 }$ are shown in FIGS. 29 and 30. In $^{1}$H-NMR analysis, minute amounts of residual solvents (methanol, water) were observed. 

[0303] Synthesis of PAG-3 

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## Example 1-3-3 

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## Example 1-3-4 

[0304] In 50 g ofN,N-dimethylformamide were dissolved 9.0 g of Intermediate P and 2.5 g of diisopropylethylamine. Under ice cooling, Compound C was added dropwise to the solution. The solution was stirred overnight at room tem› perature. Under ice cooling, 70 g of 2 wt % hydrochloric acid was added to the solution to quench the reaction. To the solution, 70 g of MIBK and 10 g of methanol were added, followed by stirring. An organic layer was taken out by separatory operation. The organic layer was washed 3 times with 15 wt% methanol aqueous solution and concentrated under reduced pressure. DIPE was added to the concentrate for crystallization. The precipitate ( solid) was filtered, washed with DIPE, and dried in vacuum, obtaining 9.1 g of the target compound, PAG-3 (yield 74%). 

[0305] PAG-3 was analyzed by spectroscopy. The NMR spectra, $^{1}$H- and $^{19}$F-NMR in DMSO-d$_{6 }$ are shown in FIGS. 31 and 32. In $^{1}$H-NMR analysis, minute amounts ofresidual solvents (DIPE, MIBK, water) were observed. 

[0306] IR (D-ATR): 3304, 3073, 1595, 1510, 1475, 1449, 1412, 1373, 1316, 1261, 1242, 1169, 1089, 1074, 1045,984, 882, 838, 812, 746, 682, 644, 586 cm- 1 

[0307] TOF-MS (MALDI): [M] 687 

[0308] Synthesis of PAG-4 to PAG-9 

[0309] PAG-4 to PAG-9, identified below, were synthe› sized in accordance with the procedures of the foregoing Examples. 

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## Examples 1-4 to 1-9 

