(c) hydroxy, 

( d) cl -C6 alkyl, 

( e) C$_{2}$-C$_{6 }$ alkenyl, 

(t) C$_{2}$-C$_{6 }$ alkynyl, 

(g) fluorinated C$_{1 }$-C$_{6 }$ alkyl, 

(h) cl -C6 alkoxy, 

(i) fluorinated C$_{1}$-C$_{6 }$ alkoxy, 

G) S-(C$_{1 }$-C$_{6 }$ alkyl), 

(k) heterocycle, or 

(1) heterocycle substituted with one or more substitu› ents independently selected from halogen, cyano, hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alky› nyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alkoxy, fluori› nated C$_{1}$-C$_{6 }$ alkoxy, S-(C$_{1}$ -C$_{6 }$ alkyl), and NR"R6; 

(ii) each of the substituents on substituted heteroaryl is independently 

(a) halogen, 

(b) cyano, 

(c) hydroxy, 

(d) NR"R6, 

( e) C$_{1}$-C$_{6 }$ alkyl, 

(t) C$_{2}$-C$_{6 }$ alkenyl, 

(g) C$_{2}$ -C$_{6 }$ alkynyl, 

(h) fluorinated C$_{1 }$-C$_{6 }$ alkyl, 

(i) C$_{1}$-C$_{6 }$ alkoxy, 

G) fluorinated C$_{1 }$-C$_{6 }$ alkoxy, 

(k) S-(C$_{1}$-C$_{6 }$ alkyl), 

(1) phenyl, 

(m) phenyl substituted with one or more substituents independently selected from halogen, cyano, hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alky› nyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alkoxy, fluori› nated C$_{1 }$-C$_{6 }$ alkoxy, and S-(C$_{1 }$-C$_{6 }$ alkyl), 

(1) heterocycle, or 

(m) heterocycle substituted with one or more sub› stituents independently selected from halogen, cyano, hydroxy, C$_{1 }$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C -C$_{6 }$ alkynyl, fluorinated C$_{1 }$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alk~xy, fluorinated C$_{1}$-C$_{6 }$ alkoxy, S-(C$_{1}$-C$_{6 }$ alkyl), NR"R6, and a 5- or 6-membered heteroaromatic ring con› sisting of carbon atoms and from 1 to 3 heteroa› toms selected from N, 0 and S; 

R 2 and R 3 are each independently hydrogen or C$_{1}$-C$_{4 }$ alkyl; or R 2 and R 3 together with the carbon to which they are attached form C$_{3}$ -C$_{6 }$ cycloalkyl; 

R $^{4 }$is C$_{1}$ -C$_{6 }$ alkyl, C$_{3}$ -C$_{6 }$ cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl; wherein each of the substituents on substituted aryl is independently halogen, hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$ -C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alkynyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1}$-C$_{6 }$ alkoxy, or het› eroaryl; and each of the substituents on substituted 

heteroaryl is independently halogen, hydroxy, cyano, C -C$_{6 }$ alkyl, C$_{2}$ -C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alkynyl, fluorinated c’-C$_{6 }$ alkyl, C$_{1}$-C$_{6 }$ alkoxy, or aryl; 1 

R $^{5 }$is carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic, wherein each of the substitu› ents on substituted carbocyclic or substituted hetero› cyclic is independently halogen, hydroxy, C$_{1 }$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$ -C$_{6 }$ alkynyl, fluorinated C$_{1 }$-C$_{6 }$ alkyl, or cl -C6 alkoxy; 

R 6 is fluorinated C$_{1 }$-C$_{6 }$ alkyl; and 

R" and Rb are each independently hydrogen or C$_{1}$-C$_{4 }$ alkyl; or R" and Rb together with the nitrogen to which they are attached form C$_{3}$-C$_{6 }$ azacycloalkyl. 

2. The composition according to claim 1, wherein the complex comprises a compound of Formula (I) or a phar› maceutically acceptable salt thereof, wherein: 

R $^{1 }$is C$_{1 }$-C$_{6 }$ alkyl, C$_{3}$-C$_{6 }$ cycloalkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein het› eroaryl is (i) a 5- or 6-membered aromatic ring con› sisting of carbon atoms and from 1 to 3 heteroatoms selected from N, S and O or (ii) an 8- to 10-membered bicyclic ring system consisting of carbon atoms and from 1 to 3 heteroatoms selected from N, S and 0, wherein at least one of the rings in the bicyclic system is an aromatic ring; wherein 

(i) each of the substituents on substituted aryl is inde› pendently 

(a) halogen, 

(b) cyano, 

(c) hydroxy, 

( d) C$_{1}$-C$_{6 }$ alkyl, 

(e) C$_{2}$-C$_{6 }$ alkenyl, 

(t) C$_{2}$-C$_{6 }$ alkynyl, 

(g) fluorinated C$_{1 }$-C$_{6 }$ alkyl, 

(h) cl -C6 alkoxy, 

(i) fluorinated C$_{1}$-C$_{6 }$ alkoxy, 

G) S-(C$_{1 }$-C$_{6 }$ alkyl), 

(k) heterocycle, or 

(1) heterocycle substituted with one or more substitu› ents independently selected from halogen, cyano, hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$ -C$_{6 }$ alky› nyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alkoxy, fluori› nated C$_{1}$ -C$_{6 }$ alkoxy, S-(C$_{1}$-C$_{6 }$ alkyl), and NR"R6; and 

(ii) each of the substituents on substituted heteroaryl is independently 

(a) halogen, 

(b) cyano, 

(c) hydroxy, 

(d) NR"R6, 

( e) C$_{1}$-C$_{6 }$ alkyl, 

(t) C$_{2}$-C$_{6 }$ alkenyl, 

