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# (19) United States 

# (12) Patent Application Publication Hsu et al. 

# (54) TRANSDERMALAND TOPICAL ADMINISTRATION OF DRUGS USING BASIC PERMEATION ENHANCERS 

(76) Inventors: Tsung-Min Hsu, San Diego, CA (US); Nicole T. Gricenko, San Diego, CA (US); Alan T.J. Hickey, San Diego, CA (US); Eric C. Jacobson, San Diego, CA (US); Rose C. LoBello, San Diego, CA (US); Jane Ohara, San Diego, CA (US); Eric C. Luo, Plano, TX (US) 

Correspondence Address: REED & ASSOCIATES 800 MENLO AVENUE SUITE 210 MENLO PARK, CA 94025 (US) 

(21) Appl. No.: 10/176,952 

(22) Filed: Jun.21,2002 

## Related U.S. Application Data 

(63) Continuation-in-part of application No. 09/972,008, filed on Oct. 4, 2001, which is a continuation-in-part 

<img src='content_image/926245.jpg'>

(51) Int. Cl.7 ....................................................... A61K 9/70 

(52) U.S. Cl. .............................................................. 424/449 

## (57) ABSTRACT 

Methods are provided for enhancing the permeability of skin or mucosal tissue to topical or transdermal application of pharmacologically or cosmeceutically active agents. The methods entail the use of a base in order to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. The permeation enhancer can be an inorganic or organic base. Compositions and transdermal systems are also described. 

US 20030124176Al 

# (10) Pub. No.: US 2003/0124176 Al 

# (43) Pub. Date: Jul. 3, 2003 

of application No. 09/738,410, filed on Dec. 14, 2000, which is a continuation-in-part of application No. 09/569,889, filed on May 11, 2000, which is a con› tinuation-in-part of application No. 09/465,098, filed on Dec. 16, 1999, now abandoned, and which is a continuation-in-part of application No. 09/738,395, filed on Dec. 14, 2000, which is a continuation of application No. 09/607,892, filed on Jun. 30, 2000, now abandoned. 

## Publication Classification 

