various amino acid moieties with suitable protecting groups, which will prevent a chemical reaction from occurring at that site until the protecting group is ultimately removed. It is also well known to protect the a-amino group on an amino acid while that entity reacts at the carboxyl group, followed by the selective removal of the a-amino protecting group to allow a subsequent reaction to take place at that site. Examples of suitable a-amino and side chain protecting groups are well known in the art. 

[0108] Alternatively, the peptide, polypeptide or protein may be prepared by employing recombinant technology via techniques well known in the art. That is, conventional recombinant techniques may be used, which, as will be appreciated by those skilled in the art, involves constructing DNA encoding the desired amino acid sequence, cloning the DNA into an expression vector, transforming a host cell, e.g., a bacterial, yeast, or mammalian cell, and expressing the DNA to produce the desired peptide, polypeptide or protein. 

[0109] Additionally, peptides, polypeptides or proteins can be obtained from natural sources such as a human or other animal, and may be extracted from either a living organism or from a cadaver. The material is separated and purified prior to incorporation into a drug delivery system or dosage form. Techniques of separation and purification are well known in the art and include, for example, centrifuga› tion. 

[0110] Although any peptidyl drug may be incorporated into the delivery systems of the present invention, the drug is generally selected from coagulation factors, cytokines, endorphins, kinins, hormones, LHRH (luteinizing hormone› releasing hormone) analogs and other peptidyl drugs that provide a desired pharmacological activity. Of course, the categories provided are not intended to be limiting and simply serve as a means for organization. As will be appreciated, a peptidyl drug may fall into more than one category. 

[0111] Many coagulation modulators are endogenous pro› teins that circulate in the blood and interact with other endogenous proteins to control blood coagulation. Preferred coagulation modulators include a $_{1 }$-antitrypsin, a $_{2}$-macro› globulin, antithrombin III, factor I (fibrinogen), factor II (prothrombin), factor III (tissue prothrombin), factor V (proaccelerin), factor VII (proconvertin), factor VIII ( anti› hemophilic globulin or AHG), factor IX (Christmas factor, plasma thromboplastin component or PTC), factor X (Stu› art-Power factor), factor XI (plasma thromboplastin ante› cedent or PTA), factor XII (Hageman factor), heparin cofac› tor II, kallikrein, plasmin, plasminogen, prekallikrein, protein C, protein S, thrombomodulin and combinations thereof. When applicable, both the "active" and "inactive" versions of these proteins are included. 

[0112] The cytokines are a large and heterogeneous group of proteins and have a role in the function of the immune system and the control of hematopoiesis, i.e., the production of blood or blood cells. Preferred cytokines include colony stimulating factor 4, heparin binding neurotrophic factor (HBNF), interferon-a, interferon a-2a, interferon a-2b, interferon a-n3, interferon-~, interferon-y, interleukin-1, interleukin-2, interleukin-3, interleukin-4, interleukin-5, interleukin-6, interleukin-7, interleukin-8, interleukin-9, interleukin-10, interleukin-11, interleukin-12, interleukin- 

13, interleukin-14, interleukin-15, interleukin-16, interleu› kin-17, tumor necrosis factor, tumor necrosis factor-a, granulocyte colony-stimulating factor, granulocyte-mac› rophage colony-stimulating factor, macrophage colony› stimulating factor, midkine, thymopoietin and combinations thereof. 

[0113] Endorphins are generally peptides or small-chain peptides that activate opiate receptors. Agonist and antago› nist derivatives of the naturally occurring endorphins are also contemplated. Representative examples of endorphins or pharmacologically active derivatives include dermorphin, dynorphin, a-endorphin, ~-endorphin, y-endorphin, a-en› dorphin [Leu$^{5}$]enkephalin, [Met$^{5}$]enkephalin, substance P, and combinations thereof. 

[0114] Peptidyl hormones may be naturally occurring or may be pharmacologically active derivatives of known hormones. In addition, peptidyl hormones may be human or be derived from other animal sources. Examples of peptidyl hormones that can be administered using the method, com› position and delivery system of the invention include, but are not limited to, activin, amylin, angiotensin, atrial natri› uretic peptide, calcitonin ( derived from chicken, eel, human, pig, rat, salmon, etc.), calcitonin gene-related peptide, cal› citonin N-terminal flanking peptide, cholecystokinin, ciliary neurotrophic factor, corticotropin (adrenocorticotropin hor› mone, corticotropin-releasing factor, epidermal growth fac› tor, follicle-stimulating hormone, gastrin, gastrin inhibitory peptide, gastrin-releasing peptide, ghrelin, glucogon, gona› dotropin-releasing factor, growth hormone releasing factor, human chorionic gonadotropin, inhibin A, inhibin B, insulin (derived from beef, human, pig, etc.), leptin, lipotropin, luteinizing hormone, luteinizing hormone-releasing hor› mone (LHRH), a-melanocyte-stimulating hormone, ~-mel› anocyte-stimulating hormone, y-melanocyte-stimulating hormone, melatonin, motilin, oxytocin (pitocin), pancreatic polypeptide, parathyroid hormone, placental lactogen, pro› lactin, prolactin-release inhibiting factor, prolactin-releasing factor, secretin, somatotropin, somatostatin, growth hor› mone-release inhibiting factor, thyrotropin (thyroid-stimu› lating hormone, thyrotropin-releasing factor, thyroxine, tri› iodothyronine, vasoactive intestinal peptide, vasopressin (antidiuretic hormone) and combinations thereof. 

[0115] Particularly preferred analogues of LHRH include buserelin, deslorelin, fertirelin, goserelin, histrelin, leupro› lide (leuprorelin), lutrelin, nafarelin, tryptorelin and combi› nations thereof. 

[0116] Other examples of hormones and hormone-related drugs include anastrozle, betamethasone, bicalutamide, des› mopressin, desogestrel, dexamethasone, dienestrol, dro› spirenone, estradiol, estropipate, ethinyl estradiol, ethyno› diol diaceate, exemestane, fludrocortisone ( e.g., fudrocortisone acetate), goserelin, hydrocortisone, letrozole, leuprolide ( e.g., leuprolide acetate), liothyronine ( e.g., lio› thyronine sodium), medroxyprogesterone ( e.g., medrox› yprogesterone acetate), methimazole, methylprednisolone ( e.g., methylprednisolone acetate), methyltestosterone, norethindrone ( e.g., norethindrone acetate), norgestimate, norgestrel, octreotide acetate, oxandrolone, oxymetholone, prednisolone, prednisone, progesterone, tamoxifen ( e.g., tamoxifen citrate), testosterone, and toremifene ( e.g., toremifene citrate). 

[0117] In addition, the peptidyl drug may be a kinin. Particularly preferred kinins include bradykinin, potentiator 

