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# c19) United States c12) Patent Application Publication 

# JEZEK et al. 

# (54) NOVEL FORMULATIONS 

(71) Applicant: Arecor Limited, Saffron Walden (GB) 

(72) Inventors: Jan JEZEK, Saffron Walden (GB); David GERRING, Saffron Walden (GB); Sarah HOWELL, Saffron Walden (GB); Leon ZAKRZEWSKI, Saffron Walden (GB) 

(21) Appl. No.: 16/610,805 

(22) PCT Filed: May 3, 2018 

(86) PCT No.: PCT /GB2018/051178 § 371 (c)(l), (2) Date: Nov. 4, 2019 

## (30) Foreign Application Priority Data 

May 5, 2017 (GB) ................................... 1707187.9 

<img src='content_image/926514.jpg'>

(51) Int. Cl. 

(52) U.S. Cl. CPC ............ A61K 38/28 (2013.01); A61K 311455 (2013.01); A61K 47126 (2013.01); A61K 9/08 (2013.01); A61K 47102 (2013.01); A61K 9/0019 (2013.01); A61K 47110 (2013.01) 

## (57) ABSTRACT 

The present invention relates inter alia to an aqueous liquid pharmaceutical formulation comprising (i) an insulin com› pound, (ii) ionic zinc, (iii) a nicotinic compound (iv) a non-ionic surfactant; and (v) a salt selected from the salts formed between Group 1 metals and a mono or divalent anion. It also provides related methods, uses and pharma› ceutical compositions. 

US 20200093894Al 

# c10) Pub. No.: US 2020/0093894 Al 

# (43) Pub. Date: Mar. 26, 2020 

## Publication Classification 

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## Specification includes a Sequence Listing. 

