content_image/902827.jpg content_image/902829.jpg content_image/902831.jpg content_image/902828.jpg content_image/902830.jpg
## <Compound (AlO)> 

10.1 g of the compound (AlO) was obtained with the same method as in the synthesis of the compound (A3) except that 15 the 6.05 g of adamantane carbonyl chloride was changed to 3.67 g of pivaloyl chloride. 

$^{1}$H-NMR (400 MHz, d6-DMSO) 0=7.89-7.76 (15H, m), 7.64 (lH, brs), 3.31 (m, 2H), 2.55 (t, 2H), 1.06 (s, 9H) 

## <Compound (All)> 

10.3 g of the compound (All) was obtained with the same method as in the synthesis of the compound (Al) except that the 6.05 g of adamantane carbonyl chloride was changed to 4.27 g of benzoyl chloride. 

$^{1}$H-NMR (400 MHz, D 2 O) o=7.98 (d, 2H), 7.80-7.63 (m, 17H), 7.55 (t, 2H), 3.11-3.06 (2H, m), 3.02-2.97 (2H, m) 

## <Compound (A12)> 

21.4 g of phthalic anhydride, 17 g of taurine, and 14.2 g of potassium acetate were added to 48 mL of acetic acid and stirred while carrying out refluxing for 2.5 hours. After cooling to 0° C. after the reaction and filtering the precipi› tate, spray washing was carried out with acetic acid and ethanol. Next, after adding the obtained crystals to a metha› nol solution of 38.6 g of triphenylsulfonium bromide and stirring for 30 minutes at room temperature, separation was carried out by adding pure water and ethyl acetate to the reaction mixture and the organic phase was cleaned with pure water, then the compound (A12) (52.3 g) was obtained by vacuum drying after distilling off the solvent under reduced pressure. 

$^{1}$H-NMR (400 MHz, D2O) o=7.85 (4H, m), 7.80-7.63 (m, 15H), 4.05 (2H, t), 3.25 (2H, t) 

## <Compound (A13)> 

13.3 g of the compound (A13) was obtained with the same method as in the synthesis of the compound (A3) except that the 10.45 g of triphenylsulfonium bromide was changed to 10.67 g of the following iodonium salt. 

$^{1}$H-NMR (400 MHz, CDC1$_{3}$ ) o=7.91 (d, 4H), 7.57 (t, 2H), 7.41 (t, 4H), 3.71-3.66 (m, 2H), 2.93-2.89 (m, 2H), 1.98- 1.62 (m, 15H) 

## <Compound (A14)> 

10.2 g of the compound (A14) was obtained with the same method as in the synthesis of the compound (A3) except that the 6.05 g of adamantane carbonyl chloride was changed to 5.38 g of benzenesulfonyl chloride. 

## <Compound (A15)> 

10.3 g of the compound (A15) was obtained with the same 65 method as in the synthesis of the compound (A3) except that the 4.42 g of 2-aminoethanesulfonic acid was changed to 

<img src='content_image/902827.jpg'>

<img src='content_image/902829.jpg'>

3.92 g of amino methanesulfonic acid and 10.45 g of triphenylsulfonium bromide was changed to 10.88 g of the following sulfonium salt. 

## <Compound (A16)> 

10.8 g of the compound (A16) was obtained with the same method as in the synthesis of the compound (A3) except that the 4.42 g of 2-aminoethanesulfonic acid was changed to 4.91 g of 3-amino propane sulfonic acid and 10.45 g of triphenylsulfonium bromide was changed to 12.65 g of the following sulfonium salt. 

## <Compound (Al 7)> 

Compound (Al 7) was obtained by performing salt exchange between sodium taurocholate (produced by Tokyo Chemical Industry Co., Ltd.) and the sulfonium salt (C). 

$^{1}$H-NMR (400 MHz, d6-DMSO) 0.6 (s, 3H), 0.8 (s, 3H), 0.9 (d, 3H), 2.6 (dd, 2H), 3.2 (m, lH), 3.3 (dd, 2H), 3.6 (m, lH), 3.8 (m, lH), 3.9 (s, !OH), 4.0 (bsd, lH), 4.3 (bsd, lH), 7.7 (m, 4H), 7.47 (t, 3H), 7.20-7.12 (m, 6H) 

## <Compound (A18)> 

The compound (A18) was obtained with the same method as in the synthesis of the compound (A3) except that adamantane carbonyl chloride was changed to dehydro› cholic acid chloride. 

The compound (A) used in the Examples and Compara› tive Examples is shown below. 

<img src='content_image/902831.jpg'>

<img src='content_image/902828.jpg'>

<img src='content_image/902830.jpg'>

