content_image/941203.jpg content_image/941202.jpg content_image/941204.jpg
(g) C$_{2}$ -C$_{6 }$ alkynyl, 

(h) fluorinated C$_{1 }$-C$_{6 }$ alkyl, 

(i) C$_{1}$-C$_{6 }$ alkoxy, 

G) fluorinated C$_{1 }$-C$_{6 }$ alkoxy, 

(k) S-(C$_{1}$-C$_{6 }$ alkyl), 

(1) phenyl, 

(m) phenyl substituted with one or more substituents independently selected from halogen, cyano, hydroxy, C$_{1}$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C$_{2}$-C$_{6 }$ alky› nyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alkoxy, fluori› nated C$_{1 }$-C$_{6 }$ alkoxy, and S-(C$_{1 }$-C$_{6 }$ alkyl), 

(1) heterocycle, or 

(m) heterocycle substituted with one or more sub› stituents independently selected from halogen, cyano, hydroxy, C$_{1 }$-C$_{6 }$ alkyl, C$_{2}$-C$_{6 }$ alkenyl, C -C$_{6 }$ alkynyl, fluorinated C$_{1 }$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ alk~xy, fluorinated C$_{1}$-C$_{6 }$ alkoxy, S-(C$_{1}$-C$_{6 }$ alkyl), NR"R6, and a 5- or 6-membered heteroaromatic ring con› sisting of carbon atoms and from 1 to 3 heteroa› toms selected from N, 0 and S. 

3. The composition according to claim 1, wherein the complex comprises a compound of Formula (I) or a phar› maceutically acceptable salt thereof, wherein: 

R 4 is 

<img src='content_image/941203.jpg'>

<img src='content_image/941202.jpg'>

each Z is independently hydrogen, halogen, hydroxy, cyano, C$_{1 }$-C$_{6 }$ alkyl, C$_{1 }$-C$_{6 }$ fluroinated alkyl, or C$_{1}$-C$_{6 }$ alkoxy; and 

q is an integer from O to 2. 

4. The composition according to claim 1, wherein the complex comprises a compound of Formula (I) or a phar› maceutically acceptable salt thereof, wherein: 

R $^{5 }$is carbocyclic, substituted carbocyclic, heterocyclic or substituted heterocyclic, wherein carbocyclic is cyclo› pentyl, indanyl, or tetralin, and heterocyclic is chro› man, thiochroman, or dioxoisothiochroman; wherein each of the substituents on substituted carbocyclic or substituted heterocyclic is independently halogen, hydroxy, C$_{1 }$-C$_{6 }$ alkyl, fluorinated C$_{1}$-C$_{6 }$ alkyl, or C$_{1}$-C$_{6 }$ alkoxy. 

5. The composition according to claim 1, wherein the complex comprises a compound of Formula (I), or a phar› maceutically acceptable salt thereof, wherein: 

R$^{6 }$is 

<img src='content_image/941204.jpg'>

6. The composition according to claim 1, wherein the complex comprises a compound of Formula (I) or a phar› maceutically acceptable salt thereof, wherein: 

