## principal suBsiDiaries anD affiliates 

(as of August 2014) 

Astellas is a group of companies engaged solely in the pharmaceutical business. The group consists of 86 companies, which include Astellas Pharma Inc., 79 consolidated subsidiaries and 6 affiliates accounted for by the equity method. Major group companies are listed as follows: 

## Americas 

## Holding company in North America 

Astellas US Holding, Inc. 1 Astellas Way, Northbrook, IL 60062, U.S.A. TEL: +1-800-695-4321 

## Regional headquarters 

Astellas US LLC 1 Astellas Way, Northbrook, IL 60062, U.S.A. TEL: +1-800-695-4321 

## R&D bases 

Astellas Pharma Global Development, Inc. Agensys, Inc. Astellas Research Institute of America LLC 

## Manufacturing bases 

Astellas Pharma Technologies, Inc. Astellas US Technologies, Inc. 

## Sales bases 

Astellas Pharma US, Inc. Astellas Pharma Canada, Inc. (Canada) Astellas Farma Brasil Importaçáo e Distribuiçáo de Medicamentos Ltda. (Brazil) 

## Other 

Astellas Venture Management LLC Astellas Scientific and Medical Affairs, Inc. 

Note: All subsidiaries for which no country has been indicated are located in the U.S. 

## EMEA 

## Holding company in EMEA 

Astellas B.V. Sylviusweg 62, PO Box 344, 2300 AH Leiden, The Netherlands TEL: +31-71-5455745 

## Regional headquarters (Astellas EMEA operations) 

Astellas Pharma Europe Ltd. 2000 Hillswood Drive, Chertsey, Surrey, KT16 0RS, U.K. TEL: +44-203-379-8000 

## R&D and manufacturing bases 

Astellas Pharma Europe B.V. (R&D and manufacturing, Netherlands) Astellas Ireland Co., Limited (Development and manufacturing, Ireland) 

## Sales bases 

Astellas Pharma Ges.m.b.H (Austria) Astellas Pharma B.V. (Belgium) Astellas Pharma s.r.o. (Czech Republic) Astellas Pharma A/S (Denmark) Astellas Pharma S.A.S. (France) Astellas Pharma GmbH (Germany) Astellas Pharmaceuticals AEBE (Greece) Astellas Pharma Kft. (Hungary) Astellas Pharma Co., Limited (Ireland) Astellas Pharma S.p.A. (Italy) Astellas Pharma B.V. (Netherlands) Astellas Pharma International B.V. (Netherlands) Astellas Pharma Sp. z o.o. (Poland) Astellas Farma Limitada (Portugal) ZAO Astellas Pharma (Russia) Astellas Pharma d.o.o. (Slovenia) Astellas Pharma (Proprietary), Ltd. (South Africa) Astellas Pharma S.A. (Spain) Astellas Pharma AG (Switzerland) Astellas Pharma ilaç Ticaret ve Sanayi A. Ş . (Turkey) Astellas Pharma Ltd. (United Kingdom) 

