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# c19) United States c12) Patent Application Publication 

# Rosania et al. 

# (54) DESIGN AND COMPOSITION OF CELL-STABILIZED PHARMACEUTICAL FORMULATIONS 

(71) Applicants:THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ANN ARBOR, MI (US); THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, URBANA, IL (US) 

(72) Inventors: Gustavo Rosania, Ann Arbor, MI (US); Paul J.A. Kenis, Champaign, IL (US); Tehetina Woldemichael, Ann Arbor, MI (US); Mikhail M. Murashov, Howell, MI (US); Phillip Rzeczycki, Ann Arbor, MI (US); Rahul K. Keswani, Canton, MI (US); Elizabeth M. Horstman, Champaign, IL (US) 

(21) Appl. No.: 16/344,262 

(22) PCT Filed: Oct. 24, 2017 

(86) PCT No.: PCT /US2017 /058017 § 371 (c)(l), (2) Date: Apr. 23, 2019 

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(60) Provisional application No. 62/412,461, filed on Oct. 25, 2016. 

(51) Int. Cl. 

(52) U.S. Cl. CPC .............. A61K 47102 (2013.01); A61K 9/107 (2013.01); A61P 29100 (2018.01); A61K 91127 (2013.01); A61K 311498 (2013.01) 

## (57) ABSTRACT 

Provided herein are physiologically insoluble insoluble forms of drugs. In particular, provided herein are physiologi› cally insoluble insoluble salts of drugs ( e.g., basic drugs) and their use in treatment of disease. 

US 20190262453Al 

# c10) Pub. No.: US 2019/0262453 Al 

# (43) Pub. Date: Aug. 29, 2019 

## Related U.S. Application Data 

## Publication Classification 

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