content_image/933262.jpg content_image/933263.jpg
# c19) United States 

# c12) Patent Application Publication Lee et al. 

# (54) ORAL FORMULATION CONTAINING ITRACONAZOLE AND METHODS FOR MANUFACTURING AND USING THE SAME 

(76) Inventors: Fang-Yu Lee, Taichia (TW); Shan-Chiung Chen, Fong Yuan City (TW); Bin-Ken Chen, Waibu Township (TW); Han-Chiang Kuo, Wan Li Township (TW) 

Correspondence Address: ANDREWS KURTH LLP 1350 I STREET, N.W. SUITE 1100 WASHINGTON, DC 20005 (US) 

(21) Appl. No.: 11/315,124 

(22) Filed: Dec. 23, 2005 

<img src='content_image/933262.jpg'>

US 20070148240Al 

# c10) Pub. No.: US 2007/0148240 Al 

# (43) Pub. Date: Jun. 28, 2007 

(51) Int. Cl. 

<img src='content_image/933263.jpg'>

(52) U.S. Cl. ...................................... 424/472; 514/254.07 

## (57) ABSTRACT 

The present invention provides oral pharmaceutical formu› lation for azole antimicrobial drugs such as itraconazole, saperconazole, ketoconazole, and fluconazole. The oral pharmaceutical formulation contains a core and a drug coating layer. The drug coating layer contains the azole antimicrobial drug and a binder, but not containing an emulsion (such as polyoxypropylene-polyoxyethylene block copolymers, polyoxyethylene-sorbitan-fatty acid esters, sodium lauryl sulfate, or vitamin E polyethylene glycol succinate) and/or an absorbent aid (such as DL-malic acid, citric acid, ascorbic acid, and alginic acid). The oral phar› maceutical formulation can optionally contain a protective layer, such as polyethylene glycol 20,000. The present invention also provides a method for preparing and using the formulation. 

## Publication Classification 

