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# c19) United States c12) Patent Application Publication 

# Liu et al. 

# (54) STABLE AQUEOUS FORMULATIONS OF AFLIBERCEPT 

(71) Applicant: Coherus BioSciences Inc., Redwood City, CA (US) 

(72) Inventors: Jun Liu, Redwood City, CA (US); Mark Manning, Redwood City, CA (US); Sekhar R. Kanapuram, Thousand Oaks, CA (US) 

(21) Appl. No.: 16/566,847 

(22) Filed: Sep. 10, 2019 

(63) Continuation-in-part of application No. 16/297,387, filed on Mar. 8, 2019, which is a continuation of application No. 62/640,411, filed on Mar. 8, 2018. 

## Related U.S. Application Data 

<img src='content_image/928598.jpg'>

(51) Int. Cl. A61K 38/17 (2006.01) A61K 47122 (2006.01) A61K 47118 (2006.01) A61K 47126 (2006.01) A61K 9/00 (2006.01) 

(52) U.S. Cl. CPC ............ A61K 38/179 (2013.01); A61K 47122 (2013.01); A61K 9/08 (2013.01); A61K 47126 (2013.01); A61K 9/0048 (2013.01); A61K 471183 (2013.01) 

## (57) ABSTRACT 

A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of aflibercept, wherein the formulation is free of organic co-solvent and/or free of buffer; methods for making such a formulation; and methods of using such a formulation. 

US 20200246423Al 

# c10) Pub. No.: US 2020/0246423 Al 

# (43) Pub. Date: Aug. 6, 2020 

## Publication Classification 

<img src='content_image/928616.jpg'>

