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# c12) United States Patent 

# Potyrailo et al. 

# (54) MATERIAL COMPOSITIONS FOR SENSORS FOR DETERMINATION OF CHEMICAL SPECIES AT TRACE CONCENTRATIONS AND METHOD OF USING SENSORS 

(75) Inventors: Radislav A. Potyrailo, Niskayuna, NY (US); Timothy M. Sivavec, Clifton Park, NY (US); Caibin Xiao, Harleysville, PA (US); Theodore J. Cecconie, Buckingham, PA (US); Lamyaa Hassib, Niskayuna, NY (US); Andrew M. Leach, Clifton Park, NY (US); David B. Engel, The Woodlands, TX (US) 

(73) Assignee: General Electric Company, Schenectady, NY (US) 

( *) Notice: Subject to any disclaimer, the term ofthis patent is extended or adjusted under 35 U.S.C. 154(b) by 1066 days. 

(21) Appl. No.: 11/259,506 

(22) Filed: Oct. 26, 2005 

## (65) Prior Publication Data 

US 2007 /0092973 Al Apr. 26, 2007 

(51) Int. Cl. GOIN 21100 (2006.01) 

(52) U.S. Cl. ....................... 436/164; 436/166; 436/167; 436/169; 436/171; 436/172; 436/800; 436/805; 422/50 

(58) Field of Classification Search ................. 436/163, 436/164, 800, 805; 422/85 See application file for complete search history. 

## (56) References Cited 

<img src='content_image/942384.jpg'>

## U.S. PATENT DOCUMENTS 

<img src='content_image/942396.jpg'>

Typical set of spectra of a molybdate sensor film device at various molybdate concentrations. 

<img src='content_image/942399.jpg'>

# (IO) Patent No.: US 7,807,473 B2 

# (45) Date of Patent: Oct. 5, 2010 

<img src='content_image/942383.jpg'>

## FOREIGN PATENT DOCUMENTS 

EP 0 952 451 10/1999 

Miniaturized Bio sensors Employing Electropolymerized Permselec› tive Films and Their Use for Creatinine Assays in Human Serum, Marcel B. Madaras and Richard P. Buck, Anal. Chem. 1996, 68, 3832-3839.* 

Primary Examiner-Jill Warden 

Assistant Examiner-Dean Kwak 

(74) Attorney, Agent, or Firm-Wegman, Hessler & Vanderburg 

## (57) ABSTRACT 

A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical compo› sition comprising an indicator that changes its optical prop› erty in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film. 

US0078074 73B2 

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## OTHER PUBLICATIONS 

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## 17 Claims, 15 Drawing Sheets 

