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[0249] To the organic layer obtained in Example 1-1-4, 130 g of Compound B and 200 g of water were added, followed by separatory operation. The organic layer was taken out, washed 3 times with 2.5 wt % aqueous solution of Compound B, and washed 5 times with deionized water. The organic layer was concentrated under reduced pressure, obtaining an oily product. DIPE was added to the product for decantation. This was followed by concentration under reduced pressure, obtaining 204 g of the end compound, Intermediate E (yield 68%). 

[0250] Intermediate E was analyzed by spectroscopy. The NMR spectra, $^{1}$H- and $^{19}$F-NMR in DMSO-d$_{6 }$ are shown in FIGS. 7 and 8. In $^{1}$H-NMR analysis, minute amounts of residual solvents (DIPE, MIBK, water) were observed. 

[0251] IR (D-ATR): 3280, 3103, 2979, 1589, 1494, 1478, 1448, 1407, 1260, 1228, 1156, 1106, 1072, 989, 966, 924, 836, 750, 732, 685, 644, 560 cm- 1 

[0252] TOF-MS (MALDI): Positive M+ 521 (correspond› ing to (C$_{6}$H$_{5}$)(C$_{6}$H$_{4}$ F)(C$_{6}$H$_{4}$OCH$_{2}$CH(CF 3 ) $_{2}$OCH$_{2}$OCH$_{3}$ ) s+) 

[0253] Negative M- 229 (corresponding to CCF$_{3}$(OH) CF$_{2}$SO$_{3}$-) 

[0254] Synthesis of Intermediate F 

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## Example 1-1-6 

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[0255] A solution of 2.5 g of sodium hydride in 125 g of THF was added dropwise to a solution of 45 g of Interme› diate E in 121 g ofTHF below 5° C. The solution was aged overnight at room temperature, after which water was added below 5° C. MIBK, 300 g, was added to the solution, followed by separatory operation. The organic layer was taken out and washed with water, then washed with 1 wt % hydrochloric acid, and washed with water again. The organic layer was taken out and concentrated under reduced pres› sure, obtaining an oily product. DIPE was added to the oily product for decantation. The solid was collected by filtration and dried in vacuum, obtaining 39 g of Intermediate F as white crystal (yield 58%). 

[0256] Intermediate F was analyzed by spectroscopy. The NMR spectra, $^{1}$H- and $^{19}$F-NMR in DMSO-d$_{6 }$ are shown in FIGS. 9 and 10. In $^{1}$H-NMR analysis, minute amounts of residual solvents (DIPE, water) were observed. 

[0257] IR (D-ATR): 3511, 3100, 2981, 1588, 1494, 1448, 1417, 1248, 1183, 1154, 1106, 1073, 996, 966, 924, 884, 834, 750, 732, 685, 642, 584 cm- 1 

[0258] TOF-MS (MALDI): [M] 731 

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