content_image/923942.jpg content_image/923943.jpg
mg/cm 2 when the calculated excess NaOH concentration in the dried patch was increased from 0.20% to 2.62% (PPA-4), i.e., up to about 4-fold more flux was obtained than in the absence of NaOH. The cumulative amount of PPA-HCl across human cadaver skin at 24 hours from the formulation with an excess NaOH concentration of 1.33% (PPA-3, 5.2 mg/cm 2 ) is about 4 times higher than that from the formu› lation with an excess Na OH concentration of 0.20% (PPA-2, 1.35 mg/cm 2 ). 

[0297] A human skin irritation study was performed using seven transdermal systems, which are listed below: 

Keto-5 (containing no ketoprofen, no NaOH) Keto-6 (containing ketoprofen, no NaOH) Keto-7 Keto-8 Keto-9 

## Example 4 

<img src='content_image/923942.jpg'>

<img src='content_image/923943.jpg'>

[0298] The Control was an occlusive chamber (Hilltop, Cincinnati, Ohio) containing petrolatum held in place with paper tape. The following procedures were used to prepare the systems with the exception of the system containing petrolatum. The formulations used to prepare these systems are listed in Table 10, which include weight and weight percent of each component in the formulations. Round disc samples were prepared as described in the Methods section, except that the discs has a diameter of ‰ inch. The theo› retical percent weight for each ingredient after drying is listed in Table 11, which was calculated assuming all the volatile ingredients were completely removed during drying. 

[0299] 

Keto-10 Control (containing petrolatum) 

-continued 

