about 140 mM to about 750 mM, about 140 mM to about 700 mM, about 140 mM to about 650 mM, about 140 mM to about 600 mM, about 140 mM to about 550 mM, about 140 mM to about 500 mM, about 140 mM to about 450 mM about 140 mM to about 400 mM, about 140 mM to abou~ 350 mM, about 140 mM to about 300 mM, about 140 mM to about 250 mM, about 140 mM to about 200 mM, about 140 mM to about 180 mM, about 140 mM to about 160 mM about 160 mM to about 1 M, about 160 mM to about 950 mM, about 160 mM to about 900 mM, about 160 mM to about 850 mM, about 160 mM to about 800 mM, about 160 mM to about 750 mM, about 160 mM to about 700 mM about 160 mM to about 650 mM, about 160 mM to abou~ 600 mM, about 160 mM to about 550 mM, about 160 mM to about 500 mM, about 160 mM to about 450 mM, about 160 mM to about 400 mM, about 160 mM to about 350 mM about 160 mM to about 300 mM, about 160 mM to abou~ 250 mM, about 160 mM to about 200 mM, about 160 mM to about 180 mM, about 180 mM to about 1 M, about 180 mM to about 950 mM, about 180 mM to about 900 mM about 180 mM to about 850 mM, about 180 mM to abou~ 800 mM, about 180 mM to about 750 mM, about 180 mM to about 700 mM, about 180 mM to about 650 mM about 180 mM to about 600 mM, about 180 mM to about 550 mM about 180 mM to about 500 mM, about 180 mM to abou~ 450 mM, about 180 mM to about 400 mM, about 180 mM to about 350 mM, about 180 mM to about 300 mM about 180 mM to about 250 mM, about 180 mM to about 200 mM about 200 mM to about 1 M, about 200 mM to about 950 mM, about 200 mM to about 900 mM, about 200 mM to about 850 mM, about 200 mM to about 800 mM, about 200 mM to about 750 mM, about 200 mM to about 700 mM about 200 mM to about 650 mM, about 200 mM to abou~ 600 mM, about 200 mM to about 550 mM, about 200 mM to about 500 mM, about 200 mM to about 450 mM about 200 mM to about 400 mM, about 200 mM to about 350 mM about 200 mM to about 300 mM, about 200 mM to abou~ 250 mM, about 250 mM to about 1 M, about 250 mM to about 950 mM, about 250 mM to about 900 mM, about 250 mM to about 850 mM, about 250 mM to about 800 mM about 250 mM to about 750 mM, about 250 mM to abou~ 700 mM, about 250 mM to about 650 mM, about 250 mM to about 600 mM, about 250 mM to about 550 mM about 250 mM to about 500 mM, about 250 mM to about 450 mM about 250 mM to about 400 mM, about 250 mM to abou~ 350 mM, about 250 mM to about 300 mM, about 300 mM to about 1 M, about 300 mM to about 950 mM, about 300 mM to about 900 mM, about 300 mM to about 850 mM about 300 mM to about 800 mM, about 300 mM to abou~ 750 mM, about 300 mM to about 700 mM, about 300 mM to about 650 mM, about 300 mM to about 600 mM about 300 mM to about 550 mM, about 300 mM to about 500 mM about 300 mM to about 450 mM, about 300 mM to abou~ 400 mM, about 300 mM to about 350 mM, about 350 mM to about 1 M, about 350 mM to about 950 mM, about 350 mM to about 900 mM, about 350 mM to about 850 mM about 350 mM to about 800 mM, about 350 mM to abou~ 750 mM, about 350 mM to about 700 mM, about 350 mM to about 650 mM, about 350 mM to about 600 mM about 350 mM to about 550 mM, about 350 mM to about 500 mM about 350 mM to about 450 mM, about 350 mM to abou~ 400 mM, about 400 mM to about 1 M, about 400 mM to about 950 mM, about 400 mM to about 900 mM, about 400 mM to about 850 mM, about 400 mM to about 800 mM, 

about 400 mM to about 750 mM, about 400 mM to about 700 mM, about 400 mM to about 650 mM, about 400 mM to about 600 mM, about 400 mM to about 550 mM about 400 mM to about 500 mM, about 400 mM to about 450 mM about 450 mM to about 1 M, about 450 mM to about 950 mM, about 450 mM to about 900 mM, about 450 mM to about 850 mM, about 450 mM to about 800 mM, about 450 mM to about 750 mM, about 450 mM to about 700 mM about 450 mM to about 650 mM, about 450 mM to abou~ 600 mM, about 450 mM to about 550 mM, about 450 mM to about 500 mM, about 500 mM to about 1 M, about 500 mM to about 950 mM, about 500 mM to about 900 mM about 500 mM to about 850 mM, about 500 mM to abou~ 800 mM, about 500 mM to about 750 mM, about 500 mM to about 700 mM, about 500 mM to about 650 mM about 500 mM to about 600 mM, about 500 mM to about 550 mM about 550 mM to about 1 M, about 550 mM to about 950 mM, about 550 mM to about 900 mM, about 550 mM to about 850 mM, about 550 mM to about 800 mM, about 550 mM to about 750 mM, about 550 mM to about 700 mM about 550 mM to about 650 mM, about 550 mM to abou~ 600 mM, about 600 mM to about 1 M, about 600 mM to about 950 mM, about 600 mM to about 900 mM, about 600 mM to about 850 mM, about 600 mM to about 800 mM about 600 mM to about 750 mM, about 600 mM to abou~ 700 mM, about 600 mM to about 650 mM, about 650 mM to about 1 M, about 650 mM to about 950 mM, about 650 mM to about 900 mM, about 650 mM to about 850 mM about 650 mM to about 800 mM, about 650 mM to abou~ 750 mM, about 650 mM to about 700 mM, about 700 mM to about 1 M, about 700 mM to about 950 mM, about 700 mM to about 900 mM, about 700 mM to about 850 mM about 700 mM to about 800 mM, about 700 mM to abou~ 750 mM, about 750 mM to about 1 M, about 750 mM to about 950 mM, about 750 mM to about 900 mM, about 750 mM to about 850 mM, about 750 mM to about 800 mM about 800 mM to about 1 M, about 800 mM to about 950 mM, about 800 mM to about 900 mM, about 800 mM to about 850 mM, about 850 mM to about 1 M, about 850 mM to about 950 mM, about 850 mM to about 900 mM, about 900 mM to about 1 M, about 900 mM to about 950 mM or 950 mM to 1 M). In one embodiment, the concentratio~ of the buffer is between 1 mM to about 150 mM. In one embodiment, the concentration of the buffer is about 5 mM to about 20 mM. In one embodiment, the concentration of the buffer is about 10 mM. Buffers are well known in the art and are manufactured by known methods and available from commercial suppliers. The selection of an appropriate buffer may be informed by data on any interactions of specific buffers with other formulation components. For example, U.S. Pat. No. 8,349,321 discloses that degradation of poly› sorbate 80 (thought to be due to a metal catalyzed oxidation of polysorbate) is significantly impeded by replacing histi› dine buffer with phosphate buffer in a tested placebo for› mulation. 

[0128] The pH of the pharmaceutical compositions of the invention is generally between 5 and 7 (e.g., about 5.0 to about 6.9, about 5.0 to about 6.8, about 5.0 to about 6.7, about 5.0 to about 6.6, about 5.0 to about 6.5, about 5.0 to about 6.4, about 5.0 to about 6.3, about 5.0 to about 6.2, about 5.0 to about 6.1, about 5.0 to about 6.0, about 5.0 to about 5.9, about 5.0 to about 5.8, about 5.0 to about 5.7, about 5.0 to about 5.6, about 5.0 to about 5.5, about 5.0 to about 5.4, about 5.0 to about 5.3, about 5.0 to about 5.2, 

