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## Specific objectives: 

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The objectives of the contract resulting from the present procurement procedure will be as follows: 

Objective 1: To identify and extract all existing biological (absorption, distribution, metabolism, and excretion (ADME) and toxicological information from repeated-dose toxicity studies for all active substances assessed by EFSA through the peer-review process in Europe and their metabolites and/or degradation products from EFSA conclusions and related risk assessment reports, using an agreed data model. 

Objective 2:  To identify and retrieve complementary mechanistic data (new approach methodologies (NAM) data) for the substances identified in Objective 1, from the open literature and other sources (e.g. Tox21, ToxCast, etc) that will reduce uncertainty in the RAx. 

Objective 3:  Once the information has been captured and curated in the database, the substances to be studied will be analysed for RAx using (i) chemical structure determinants and (ii) biological, toxicological and mechanistic information. Analogue and category approaches will be assessed. This objective should provide an analysis of the parameters and determinants necessary for a reliable and reproducible RAx. 

## 1.3 TASKS, DELIVERABLES, TIMELINE AND PAYMENTS 

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