•Adult hRPESC-derived RPE had comparable in vitro characteristics to fetal hRPE•hRPE monolayers survived 4 weeks on PET carriers under the rabbit retina•Better xenograft survival may be due to the maintained hRPE cell polarity•Atrophy of the retina overlaying the hRPE xenograft remains a future challenge
hRPE monolayers
survived
4 weeks
weeks