Although women who have already had children or who have already entered menopause aren't necessarily worried about not being able to become mothers as a result of hormone therapy, estrogen also protects bones, so the lack of it cannot be ignored, because it can lead to joint pain, osteoporosis, and even bone fractures.
對於已生育或已停經婦女而言，接受荷爾蒙療法雖然沒有不能當媽媽的困擾與掙扎，但雌激素另具有保護骨骼的功能，失去雌激素會導致關節疼痛、骨質疏鬆甚至骨折，仍必須小心處理。