Currently there is no consensus even on who should organize an external monitoring committee, so even this basic step has still not passed review with the Academia Sinica's IRB.
＊多數遺傳性疾病目前根本無法可治。（如杭亭頓舞蹈症等）＊許多疾病未發生前亦無法治療。（如乳癌未發生前，事先割除乳房是否合理？）＊胚胎組織採樣過程可能會傷害胎兒。