While receiving hormone treatment (at least five years), the lack of estrogen induces menopause-like symptoms including a reduction in or even cessation of menstruation, infertility, dryness of the vaginal area, coarse skin, and hot flashes, leading to psychological frustration and struggles. Many patients that have not yet married or had children feel that they are "no longer women."
對於未婚或者尚未生育的婦女而言，在接受荷爾療法期間內（至少 5 年），因雌激素不足，月經會減少甚至停止，無法受孕，甚至有陰道乾燥、皮膚粗糙、潮紅冒汗等更年期症狀出現，讓患者覺得自己「不再是女人了」，心理上的挫折可想而知。