The most intense form of gender dysphoria is called transsexuality. People who are primary transsexuals harbor lifelong desires to change their sex. They often fall into deep depressions and feel suicidal.
在所有性別焦慮症候群中，終其一生都想要完全改變性別的變性慾者最嚴重，也最令當事人痛苦，經常陷入憂鬱症和自殺的意圖中。