In 1958, after chromosome assay methods became available, people were well aware that congenital diseases such as Down's syndrome were linked to chromosomal aberrations, but at the time nobody made the connection that cancer, with its numerous forms and symptoms, also involved chromosomes.
1958 年，染色體檢驗方法出來後，大家只知道如唐氏症等遺傳疾病與染色體變異有關，並沒有人聯想到種類繁多、症狀多變的癌症，竟然也會與染色體牽扯不清。