Three great Renaissance masters were all active during this period: Da Vinci painted The Last Supper and the Mona Lisa; Michelangelo sculpted David and painted the ceiling of the Sistine Chapel; and Raphael, renowned for his portraits of the Virgin Mary, completed The School of Athens and The Birth of Venus.
知名的文藝復興三傑都在此時創出鉅作：達文西畫出耶穌被猶大出賣「最後的晚餐」，及笑容神秘的「蒙娜麗莎」；米開朗基羅雕成「大衛像」，並在西斯汀教堂完成了「亞當的創造」壁畫；而以畫聖母像聞名的拉斐爾則完成了「雅典思想學院」、「維納斯的誕生」。