Extended use of Ecstasy, a stimulant, can be toxic too, leading to hypertension, cardiac arrhythmias, abnormal hemostasis, and acute renal failure. It even happens from time to time that a person's body is hypersensitive to the substance, and they die from anaphylactic shock the very first time.
長期使用「搖頭丸」（中樞興奮劑），也會引發毒性，導致高血壓、心律不整、凝血障礙及急性腎衰竭等病變，醫界也有過幾個體質特殊、第一次吃搖頭丸就猝死的個案。