Over the following centuries the church fell victim to fires and was rebuilt, until in 1835 the last major fire destroyed all of Macao's oldest church bar its front façade, which has become a landmark and symbol of Macao.
聖保祿教堂多次歷經祝融之災又重修，1835 年，最後一場大火把澳門這座最早的天主教建築燒得只剩前壁，就是如今澳門的象徵──「大三巴牌坊」。