After completing his studies, he became an assistant professor at Duke University, as well as practising as a physician at a medical center. At the same time, he began research on Pompe disease, an ailment whose effective treatment had long eluded medical science.
學成後他進入美國杜克大學擔任助理教授，並兼任醫學中心醫師，同時也開始投入長期以來令全球醫生及科學家束手無策的「龐貝氏症」研究。