Currently this drug has a high dosage (an injection once every two to four weeks, adjusted thereafter according to individual circumstances with some people stopping after a year or two) as well as a steep price, so major private insurers in the US will not cover those with mild allergies or whose symptoms are treatable with steroids. Thus the opportunities for using it are few, and this is a major downside.
由於目前該藥物因用量大（2-4 週打一針，視個別情況而定，有些人在一、二年後即可停藥）、價格昂貴，因此病情輕微或是其他類固醇藥物可以治療者，美國各大私人健保公司都不給付，使用機會低，這是一個很大的缺陷。