In 1990 the Department of Health of the Executive Yuan commissioned Lin Hsiou-chuan of the Pediatrics department of Cheng Kung University Hospital to do a study of more than 20 hospitals in Taiwan that keep records of birth defects. She discovered that the domestic incidence of Down's syndrome was 1.18 per 1.000 births.
根據民國七十九年衛生署委託成功大學附設醫院小兒科醫師林秀娟，對台灣地區廿幾家有做「先天缺陷登記」的醫院調查，發現國人唐氏症的發生率約為千分之一．一八。