The biggest problem with eating raw seafood is the possible danger to health. History of the Latter Han records how a prefect of Yangzhou felt an oppressive irritation in his chest, was red in the face and could not swallow food. After taking some medicine given him by the great physician Hua Tuo, he spat up half a gallon of worms, mixed with fragments of raw fish.
生吃海鮮其實最怕出現衛生問題，《後漢書．華佗傳》記載，廣陵太守陳登胸中悶煩，面紅無法進食，吃了神醫華佗的藥後，竟吐出三升多的蟲，蟲嘴上還咬著生魚片。