Looking back, the mass death that afflicted tilapia throughout Taiwan in 1991 prompted fish farmers to begin large-scale use of antibiotics such as chloramphenicol. Moreover, as the population density within fishponds increased, with more than 30,000 fry commonly placed in a single pond, the problem of drug use became one that could never be satisfactorily resolved.
回顧歷史，一九九一年，全台爆發吳郭魚大量暴斃案，養殖業者開始大規模使用氯黴素等抗生素，加上魚塭密度愈來愈高，一甲魚塭飼放的魚苗常高達三萬尾以上，用藥的問題一直無法妥善解決。