There is a close relationship between ovulation activity and hormones produced by the brain. Pressure can cause irregular hormone release, which affects ovulation. Further, the oviduct and vagina are controlled by the "autonomous nervous system" so that changes in mood can indirectly lead to cramps or spasms in the two areas.
這是由於卵巢活動與腦部分泌的荷爾蒙互動密切，而壓力能使芍爾蒙分泌異常，進而影響排卵；此外輸卵管與陰道受自律神經系統支配，情緒不正常會間接導致兩者痙攣。