More than 30 years ago, attempts were made to compensate for the body's lack of the critical enzyme by injecting it. However, after being introduced into the body, the enzyme only remained in the bloodstream, unable to penetrate into cells, and consequently the therapeutic effect was negligible.
雖然早在三十多年前已有人嘗試以補充酵素來治療病童，但酵素打入體內後只能停留在血液中，無法進到細胞裡，毫無功效可言。