The ROC had been represented in the Portuguese colony by the Taipei Trade and Tourism Office, which was under the Ministry of Foreign Affairs. But now the Taipei Economic and Cultural Center, under the Mainland Affairs Council, represents the ROC in this PRC Special Administrative Region.
一九九九年十二月二十日，澳門治權轉移之後，台澳之間進入新的階段，原先隸屬於外交部的我駐澳單位「台北貿易旅遊辦事處」也將更名為「台北經濟文化中心」，由掌理大陸事務的陸委會管轄。