Li Tse-yao, a doctor in the Ob-Gyn ward at National Taiwan University Hospital, reminds women that although hormone therapy can ameliorate a number of uncomfortable symptoms associated with menopause, research has also demonstrated that long-term use increases the risk of contracting ovarian and breast cancers, and can also interfere with liver function.
台大醫院婦產科醫師李鎡堯也常提醒婦女，荷爾蒙治療雖可為更年期女性減少許多不適的症狀，但也有研究發現長期使用它會提高婦女罹患子宮內膜癌、乳癌的機率，以及易造成肝功能不佳。