Nevertheless, because the globulin is extracted from blood it does not necessarily contain antibodies to enterovirus type 71, and it is perhaps only appropriate for those in critical condition or with immature immune systems. Some experts look askance at parents who request and doctors who prescribe injections of immunoglobulin.
不過由於經由血液萃取的免疫球蛋白不見得都有腸病毒七十一型抗體，而且較適用於免疫系統尚未成熟或是生命垂危者，因此面對許多主動要求施打及推薦免疫球蛋白的家長及醫師，也有專家持保留態度。