In order to bring CHM to the level of being "small, but not too small," Yang followed the approach adopted in Japan. There, the lower limit of refinement is deemed to be the point at which the cell is destroyed, when the membrane and the cell wall are broken through.
為了讓中草藥「很小又不會太小」，楊建新仿效日本，以「細胞剛破碎、細胞膜和細胞壁剛被打開」做為微小化的極限。