Although older mothers have a higher rate of babies with these chromosomal abnormalities, the occurrence of other developmental defects among newborns, including congenital heart disease, congenital metabolic disorder, hypothyroidism, galactosemia, glucose-6-phosphate dehydrogenase deficiency, as well as nervous disorders such as autism and ADHD, don't seem to increase among older mothers.
雖然高齡產婦懷有染色體異常寶寶的比例確實較高，但其他新生兒常見的發展缺陷或罕見疾病，如先天性心臟病、先天性代謝疾病（甲狀腺低能、半乳糖血症、蠶豆症等），以及自閉症、過動症等精神疾病，均與孕婦年齡無顯著相關。