As historical records reveal again and again, from the time of Cheng Cheng-kung (Koxinga) of the Ming Dynasty, through the Ching Dynasty to the Japanese occupation, Taiwan was hit by outbreaks of febrile diseases almost every three to five years.
史籍斑斑，從明鄭、清朝到日據時代，台灣幾乎是三、五年就會來一次瘟病大流行。