According to Lou Ru-pin, early research assumed that depression was the result of pressure. In the 1960's, for example, there was research indicating that sufferers from depression were likely to have faced more pressure in the previous half year than non-sufferers.
陸汝斌指出，早年的研究大都以為憂鬱症是壓力引起的，例如六○年代有研究顯示，憂鬱症患者發病的前半年，面對的壓力比沒有憂鬱症者高。