In serious cases, the person affected grows irritable and depressed. If these problems coincide with major upsets in one's personal life, such as unemployment, the death of a parent, or divorce, the combined impact of the physical and emotional challenges can bring on a crisis.
嚴重的人還會有不自覺的脾氣暴躁與情緒沮喪，如果這時又遭逢一些重大生命事件如失業、父母逝世或離婚等，生理、心理因素相乘，就容易釀成危機。