Throughout his life, the theme of his works never strayed from that of the corruption and degradation caused by old-fashioned customs and traditions, the humiliation of the common people, and the struggles of the weak and underprivileged in society.
賴和一生創作的主題不脫離舊社會習俗的敗壞，被屈辱的人民和弱者的奮鬥等。受他影響的後進有楊逵、王詩琅、呂若赫、吳濁流、葉石濤等人。