In addition, the dosage is too high for about 15 % of asthma sufferers--those most severely affacted--because they have too much IgE in their systems (700 IU per milliliter of blood), so they were excluded from the early phase of clinical trials. Even though the drug has now been approved, this group lost their chance for treatment.
此外，有大約 15％的極重度哮喘病人，因體內的 IgE 太高（每毫升血液中超過 700 國際單位），藥物的使用量太大，早期臨床試驗階段被排除，現在即使藥物通過審核，此一族群也不適用，失去被照顧的機會。