The emergence of treatment by transdermal engaged in manufacture of estrogen products were found to be affected by long-term exposure to the hormone: their skin became more delicate, their breasts began to swell up, and other female physical characteristics emerged.
貼劑藥物治療方式在西方的出現，其中有一些偶然。在一九六○年代，曾經有美國男工在生產女性荷爾蒙產品時，因長期接觸女性荷爾蒙，竟然皮膚變細了，乳房也腫大起來，出現了許多女性特徵。