Given that the vast majority of sufferers only experience mild illness, there is the risk of Tamiflu misuse. When the patient feels better, he may take it upon himself to stop taking the medicine, and any remaining viruses may become resistant and can infect other people.
尤其當輕症患者極多時，若濫用克流感，一旦病患覺得「已經沒事了！」而擅自停藥，殘存的病毒產生抗藥性後又感染他人，那才真是醫界的最大夢魘。