If a person loses a person, affair, or thing that is extremely meaningful such as physical health, a loved one, wealth, profession, self-respect, or feelings of success he can become permanently pessimistic about everything.
一個人若失去了對他十分重要的人、事、物，如身體健康、愛人、財產、工作或自尊心、成就感等，也容易萬念俱灰。