ACT_SITE 131; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 134; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 239; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 316; /evidence="ECO:0000250|UniProtKB:Q96FW1"