ACT_SITE 23; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 51; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 151; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"