ACT_SITE 48; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 76; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 176; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"