ACT_SITE 457; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 534; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352, ECO:0000269|PubMed:19435780"; ACT_SITE 538; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"