ACT_SITE 113; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 116; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 223; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 298; /evidence="ECO:0000250|UniProtKB:Q96FW1"