ACT_SITE 106; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:11029590"; ACT_SITE 162; /note="Charge relay system"; /evidence="ECO:0000305|PubMed:11029590"; ACT_SITE 185; /note="Charge relay system"; /evidence="ECO:0000305|PubMed:11029590"