ACT_SITE 221; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 300; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 384; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 388; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 417; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 421; /evidence="ECO:0000250|UniProtKB:Q38860"