ACT_SITE 13; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00011"; ACT_SITE 133; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"