ACT_SITE 166; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"; ACT_SITE 334; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"; ACT_SITE 363; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"