ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 116; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 216; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"