ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03127"; ACT_SITE 94; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03127"; ACT_SITE 229; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"