ACT_SITE 42; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 45; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066"; ACT_SITE 148; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"