ACT_SITE 17; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 45; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 156; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"