ACT_SITE 143; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 146; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 247; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 323; /evidence="ECO:0000250|UniProtKB:Q96FW1"