ACT_SITE 117; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 120; /note="Nucleophile"; /evidence="ECO:0000305"; ACT_SITE 222; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 294; /evidence="ECO:0000250|UniProtKB:Q96FW1"