ACT_SITE 360; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:29476094"; ACT_SITE 491; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:29476094"; ACT_SITE 512; /evidence="ECO:0000250|UniProtKB:Q99K23"