ACT_SITE 190; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 360; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"; ACT_SITE 393; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037"