The region does matter, It determines what pokemon you had to choose for starters when your character began their journey.m<a class="postlink" href="http://www.serebii.net/pokearth/">http://www.serebii.net/pokearth/</a>mHere's reference of pokearth, if you only played blue, then your starter choices are Bulbasaur, Charmander and Squirtle from the kanto region.