Discovery of (S)-N-{2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methanesulfonylethyl]-1,3-Dioxo-2,3-Dihydro-1h-Isoindol-4-Yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-Α Inhibitor