Infectious pancreatic necrosis
A sharp rise in mortality is often seen (depending on the virulence of the disease). Other clinical signs include abdominal swelling, anorexia, abnormal swimming, darkening of the skin, and trailing of the feces from the vent. On necropsy, internal damage (viral necrosis) to the pancreas and thick mucus in the intestines often is present. Surviving fish should recover within one to two weeks. Diagnostic methods for the detection of the disease include: characteristic histological pancreatic lesion, PCR, indirect fluorescent antibody testing, ELISA, and virus culture. High virus titers can be isolated from carrier animals. Currently, no treatment is available. However, in certain territories vaccines are available for prevention of the disease e.g. Winvil 3 Micro 
Good husbandry measures, such as high water quality, low stocking density, and no mixing of batches, help to reduce disease incidence. To eradicate the disease, very strict protocol with regards to movement, water sources and stock replacement must be in place – and still it is difficult to achieve and comes at a high economic cost.
Clinical signs and diagnosis
Infectious pancreatic necrosis (IPN) is a severe viral disease of salmonid fish.